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Sequences

Sequence DAB2IP.fAug05

GGAATACAAAAGGAGGAACCCAGACGCTCATGGAGACAGCCTCGGTTCATAAATCAGGTGGGGCCAGGGGCTGGGGGCCCACACGCCATGGAGCCCGACT CCCTTCTGGACCAAGACGACTCCTACGAGTCGCCTCAAGAAAGGCCGGGCTCTCGGCGCAGCCTGCCTGGCAGCCTTTCCGAGAAGAGCCCCAGCATGGA GCCCTCGGCCGCCACGCCGTTCCGGGTCACGGTCCCATCTGATGCCGAGGCTGAAGGAGTCTCGCTCCCACGAGTCCCTGCTCAGCCCCAGCAGTGCGGT GGAGGCGCTGGACCTCAGCATGGAGGAAGAGGTGGTCATCAAGCCCGTGCACAGCAGCATCCTTGGCCAGGACTACTGCTTCGAGGTGACGACGTCATCA GGAAGCAAGTGCTTTTCCTGCCGGTCTGCAGCTGAGCGGGATAAGTGGATGGAGAACCTCCGGCGAGCGGTGCATCCCAACAAGGACAACAGCCGGCGTG TGGAGCACATCCTGAAGCTGTGGGTGATCGAGGCCAAGGACCTGCCAGCCAAGAAGAAGTACCTGTGCGAGCTGTGCCTGGACGATGTGCTCTATGCCCG CACCACGGGCAAGCTCAAGACGGACAATGTTTTCTGGGGCGAGCACTTCGAGTTCCACAACTTGCCGCCTCTGCGCACGGTCACTGTCCACCTGTACCGG GAGACCGACAAGAAGAAGAAGAAGGAGCGCAACAGTTACCTGGGCCTGGTGAGCCTACCTGCTGCCTCGGTGGCCGGGCGGCAGTTCGTGGAGAAGTGGT ACCCGGTGGTGACGCCCAACCCCAAGGGCGGCAAGGGCCC

DAB2IP.F3 (forward primer)
DAB2IP.R3 (reverse primer)
Single exon skipping

Frame 0

GIQKEEPRRSWRQPRFINQVGPGAGGPHAMEPD SLLDQDDSYESPQERPGSRRSLPGSLSEKSPSME PSAATPFRVTVPSDAEAEGVSLPRVPAQPQQCG GGAGPQHGGRGGHQARAQQHPWPGLLLRGDDVI RKQVLFLPVCS*AG*VDGEPPASGASQQGQQPAC GAHPEAVGDRGQGPASQEEVPVRAVPGRCALCP HHGQAQDGQCFLGRALRVPQLAASAHGHCPPVP GDRQEEEEGAQQLPGPGEPTCCLGGRAAVRGEVV PGGDAQPQGRQGP

Frame 1

EYKRRNPDAHGDSLGS*IRWGQGLGAHTPWSPT PFWTKTTPTSRLKKGRALGAACLAAFPRRAPAW SPRPPRRSGSRSHLMPRLKESRSHESLLSPSSAV EALDLSMEEEVVIKPVHSSILGQDYCFEVTTSS GSKCFSCRSAAERDKWMENLRRAVHPNKDNSRR VEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYR ETDKKKKKERNSYLGLVSLPAASVAGRQFVEKW YPVVTPNPKGGKG

Frame 2

NTKGGTQTLMETASVHKSGGARGWGPTRHGARL PSGPRRLLRVASRKAGLSAQPAWQPFREEPQHG ALGRHAVPGHGPI*CRG*RSLAPTSPCSAPAVR WRRWTSAWRKRWSSSPCTAASLARTTASR*RRHQ EASAFPAGLQLSGISGWRTSGERCIPTRTTAGV WSTS*SCG*SRPRTCQPRRSTCASCAWTMCSMP APRASSRRTMFSGASTSSSTTCRLCARSLSTCTG RPTRRRRRSATVTWAW*AYLLPRWPGGSSWRSG TRW*RPTPRAARA

Sequence DAB2IP.eAug05

GGAATACAAAAGGAGGAACCCAGACGCTCATGGAGACAGCCTCGGTTCATAAATCAGGTGGGGCCAGGGGCTGGGGGCCCACACGCCATGGAGCCCGACT CCCTTCTGGACCAAGACGACTCCTACGAGTCGCCTCAAGAAAGGCCGGGCTCTCGGCGCAGCCTGCCTGGCAGCCTTTCCGAGAAGAGCCCCAGCATGGA GCCCTCGGCCGCCACGCCGTTCCGGGTCACGGGCTTCCTCAGCCGCCGCCTCAAGGGCTCCATCAAGCGCACCAAGAGCCAGCCCAAGCTGGACCGCAAC CACAGCTTCCGCCACATCCTGCCGGGGTTCCGGAGCGCCGCCGCCGCCGCCGCGGACAATGAGAGGTCCCATCTGATGCCGAGGCTGAAGGAGTCTCGCT CCCACGAGTCCCTGCTCAGCCCCAGCAGTGCGGTGGAGGCGCTGGACCTCAGCATGGAGGAAGAGGTGGTCATCAAGCCCGTGCACAGCAGCATCCTTGG CCAGGACTACTGCTTCGAGGTGACGACGTCATCAGGAAGCAAGTGCTTTTCCTGCCGGTCTGCAGCTGAGCGGGATAAGTGGATGGAGAACCTCCGGCGA GCGGTGCATCCCAACAAGGACAACAGCCGGCGTGTGGAGCACATCCTGAAGCTGTGGGTGATCGAGGCCAAGGACCTGCCAGCCAAGAAGAAGTACCTGT GCGAGCTGTGCCTGGACGATGTGCTCTATGCCCGCACCACGGGCAAGCTCAAGACGGACAATGTTTTCTGGGGCGAGCACTTCGAGTTCCACAACTTGCC GCCTCTGCGCACGGTCACTGTCCACCTGTACCGGGAGACCGACAAGAAGAAGAAGAAGGAGCGCAACAGTTACCTGGGCCTGGTGAGCCTACCTGCTGCC TCGGTGGCCGGGCGGCAGTTCGTGGAGAAGTGGTACCCGGTGGTGACGCCCAACCCCAAGGGCGGCAAGGGCCC

DAB2IP.F3 (forward primer)
DAB2IP.R3 (reverse primer)
Single exon skipping

Frame 0

GIQKEEPRRSWRQPRFINQVGPGAGGPHAMEPD SLLDQDDSYESPQERPGSRRSLPGSLSEKSPSME PSAATPFRVTGFLSRRLKGSIKRTKSQPKLDRN HSFRHILPGFRSAAAAAADNERSHLMPRLKESR SHESLLSPSSAVEALDLSMEEEVVIKPVHSSILG QDYCFEVTTSSGSKCFSCRSAAERDKWMENLRR AVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYL CELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP PLRTVTVHLYRETDKKKKKERNSYLGLVSLPAA SVAGRQFVEKWYPVVTPNPKGGKG

Frame 1

EYKRRNPDAHGDSLGS*IRWGQGLGAHTPWSPT PFWTKTTPTSRLKKGRALGAACLAAFPRRAPAW SPRPPRRSGSRASSAAASRAPSSAPRASPSWTAT TASATSCRGSGAPPPPPRTMRGPI*CRG*RSLA PTSPCSAPAVRWRRWTSAWRKRWSSSPCTAASL ARTTASR*RRHQEASAFPAGLQLSGISGWRTSGE RCIPTRTTAGVWSTS*SCG*SRPRTCQPRRSTC ASCAWTMCSMPAPRASSRRTMFSGASTSSSTTC RLCARSLSTCTGRPTRRRRRSATVTWAW*AYLLP RWPGGSSWRSGTRW*RPTPRAARA

Frame 2

NTKGGTQTLMETASVHKSGGARGWGPTRHGARL PSGPRRLLRVASRKAGLSAQPAWQPFREEPQHG ALGRHAVPGHGLPQPPPQGLHQAHQEPAQAGPQ PQLPPHPAGVPERRRRRRGQ*EVPSDAEAEGVSL PRVPAQPQQCGGGAGPQHGGRGGHQARAQQHPW PGLLLRGDDVIRKQVLFLPVCS*AG*VDGEPPA SGASQQGQQPACGAHPEAVGDRGQGPASQEEVPV RAVPGRCALCPHHGQAQDGQCFLGRALRVPQLA ASAHGHCPPVPGDRQEEEEGAQQLPGPGEPTCC LGGRAAVRGEVVPGGDAQPQGRQGP

Sequence DAB2IP.aAug05

CCAGCGGCCGAATTAACTGGTTCTGTCTGTACGACTGGGAGAGCAGCTCTCGCTAAAAATAGCGCCCTGCCCAGCTCGACCTGCGAGCCGCCGTTGGATT CTGAGCCGGGAGCCCTGCACACCCCTCACCCCGGGCCTGGCCCGGGACCGACCACGGAGGCGGAGGCCGCGGGCACCGCGCTGGCCCCACAGGTGCCGCG GAGGGTGGCAGGCCCGCTGGCCGAGGCACTGCCGAGGCCGTCCGAGATGGGAGCTGGCGGTGCCTCCTTCCGCGCCCTCGCCTGGGCCTCCCTGCCCCTG CTGGGGCCTCCAGCCTGCGCGCTCTGCGAGGACACGCTCTGCTGCGGAGAGTCGCCTCAAGAAAGGCCGGGCTCTCGGCGCAGCCTGCCTGGCAGCCTTT CCGAGAAGAGCCCCAGCATGGAGCCCTCGGCCGCCACGCCGTTCCGGGTCACGGGCTTCCTCAGCCGCCGCCTCAAGGGCTCCATCAAGCGCACCAAGAG CCAGCCCAAGCTGGACCGCAACCACAGCTTCCGCCACATCCTGCCGGGGTTCCGGAGCGCCGCCGCCGCCGCCGCGGACAATGAGAGGTCCCATCTGATG CCGAGGCTGAAGGAGTCTCGCTCCCACGAGTCCCTGCTCAGCCCCAGCAGTGCGGTGGAGGCGCTGGACCTCAGCATGGAGGAAGAGGTGGTCATCAAGC CCGTGCACAGCAGCATCCTTGGCCAGGACTACTGCTTCGAGGTGACGACGTCATCAGGAAGCAAGTGCTTTTCCTGCCGGTCTGCAGCTGAGCGGGATAA GTGGATGGAGAACCTCCGGCGAGCGGTGCATCCCAACAAGGACAACAGCCGGCGTGTGGAGCACATCCTGAAGCTGTGGGTGATCGAGGCCAAGGACCTG CCAGCCAAGAAGAAGTACCTGTGCGAGCTGTGCCTGGACGATGTGCTCTATGCCCGCACCACGGGCAAGCTCAAGACGGACAATGTTTTCTGGGGCGAGC ACTTCGAGTTCCACAACTTGCCGCCTCTGCGCACGGTCACTGTCCACCTGTACCGGGAGACCGACAAGAAGAAGAAGAAGGAGCGCAACAGTTACCTGGG CCTGGTGAGCCTACCTGCTGCCTCGGTGGCCGGGCGGCAGTTCGTGGAGAAGTGGTACCCGGTGGTGACGCCCAACCCCAAGGGCGGCAAGGGCCCTGGA CCCATGATCCGCATCAAGGCGCGCTACCAAACCATCACCATCCTGCCCATGGAGATGTACAAAGAGTTCGCTGAGCACATCACCAACCACTACCTGGGGC TGTGTGCAGCCCTCGAGCCCATCCTCAGTGCCAAGACCAAGGAGGAGATGGCATCTGCCCTGGTGCACATCCTGCAGAGCACGGGCAAGGTGAAGGACTT CCTGACAGACCTGATGATGTCAGAGGTGGACCGCTGCGGGGACAACGAGCACCTCATCTTCCGGGAGAACACACTGGCCACCAAGGCCATTGAGGAGTAC CTCAAGCTAGTGGGCCAGAAGTACCTGCAGGACGCCCTAGGTGAGTTCATCAAAGCGCTGTATGAGTCAGATGAGAACTGCGAAGTGGATCCCAGCAAGT GCTCGGCCGCTGACCTCCCAGAGCACCAGGGCAACCTCAAGATGTGCTGCGAGCTGGCCTTCTGCAAGATCATCAACTCCTACTGTGTCTTCCCACGGGA GTTGAAAGAGGTGTTTGCCTCGTGGAGGCAGGAGTGCAGCAGTCGCGGCCGCCCGGACATCAGTGAGCGGCTCATCAGCGCCTCCCTCTTCCTGCGCTTC CTCTGCCCAGCCATCATGTCGCCCTCACTCTTCAACCTGCTGCAGGAGTACCCTGATGACCGCACTGCCCGCACCCTCACCCTCATCGCCAAGGTCACCC AGAACCTGGCCAACTTTGCCAAATTTGGCAGCAAGGAGGAATACATGTCCTTCATGAACCAGTTCCTAGAGCATGAGTGGACCAACATGCAGCGCTTCCT GCTGGAGATCTCCAACCCCGAGACCCTCTCCAATACAGCCGGCTTCGAGGGCTACATCGACCTGGGCCGCGAGCTCTCCAGCCTGCACTCACTGCTCTGG GAGGCCGTCAGCCAGCTGGAGCAGAGCATAGTATCCAAACTGGGACCCCTGCCTCGGATCCTGAGGGACGTCCACACAGCACTGAGCACCCCAGGTAGCG GGCAGCTCCCAGGGACCAATGACCTGGCCTCCACACCGGGCTCTGGCAGCAGCAGCATCTCAGCTGGGCTGCAGAAGATGGTGATTGAGAACGATCTTTC CGGTCTGATAGATTTCACCCGGTTACCGTCTCCAACCCCCGAAAACAAGGACTTGTTTTTTGTCACAAGGTCCTCCGGGGTCCAGCCCTCACCTGCCCGC AGCTCGAGTTACTCGGAAGCCAACGAGCCTGATCTTCAGATGGCCAACGGTGGCAAGAGCCTCTCCATGGTGGACCTCCAGGACGCCCGCACGCTGGATG GGGAGGCAGGCTCCCCGGCGGGCCCCGACGTCCTCCCCACAGATGGGCAGGCCGCTGCAGCTCAGCTGGTGGCCGGGTGGCCGGCCCGGGCAACCCCAGT GAACCTGGCAGGGCTGGCCACGGTGCGGCGGGCAGGCCAGACACCAACCACACCAGGCACCTCCGAGGGCGCGCCAGGCCGGCCCCAGCTGTTGGCACCG CTCTCCTTCCAGAACCCTGTGTACCAGATGGCGGCTGGCCTGCCGCTGTCACCCCGTGGCCTTGGCGACTCAGGCTCTGAGGGCCACAGCTCCCTGAGCT CACACAGCAACAGCGAGGAGTTGGCGGCTGCTGCCAAGCTGGGAAGTTTCAGCACTGCCGCGGAGGAGCTGGCTCGGCGGCCCGGTGAGCTGGCACGGCG ACAGATGTCACTGACTGAAAAAGGCGGGCAGCCCACGGTGCCACGGCAGAACAGTGCTGGCCCCCAGAGGAGGATCGACCAGCCTCCGCCCCCACCCCCG CCGCCACCTCCTGCCCCCCGCGGCCGGACGCCCCCCAACCTGCTGAGCACCCTGCAGTACCCAAGACCCTCAAGCGGAACCCTGGCGTCGGCCTCACCTG ATTGGGTGGGCCCCAGTACCCGCCTGAGGCAGCAGTCCTCTTCCTCCAAGGGGGACAGCCCAGAACTGAAGCCACGGGCAGTGCACAAGCAGGGCCCTTC ACCTGTGAGCCCCAATGCCCTGGACCGCACAGCCGCTTGGCTCTTGACCATGAACGCGCAGTTGTTAGAAGACGAGGGCCTGGGCCCAGACCCCCCCCAC AGGGATAGGCTAAGGAGTAAGGACGAGCTCAGCCAAGCAGAAAAGGACCTGGCGGTGCTGCAGGACAAGCTGCGAATCTCCACCAAGAAGCTGGAGGAGT ATGAGACCCTGTTCAAGTGCCAGGAGGAGACGACGCAGAAGCTGGTGCTGGAGTACCAGGCACGGCTGGAGGAGGGCGAGGAGCGGCTGCGGCGGCAGCA GGAGGACAAGGACATCCAGATGAAGGGCATCATCAGCAGGTTGATGTCCGTGGAGGAAGAACTGAAGAAGGACCACGCAGAGATGCAAGCGGCTGTGGAC TCCAAACAGAAGATCATTGATGCCCAGGAGAAGCGCATTGCCTCGTTGGATGCCGCCAATGCCCGCCTCATGAGTGCCCTGACCCAGCTGAAAGAGAGTA TGCATTAGAAACAAAAGCCCGCTTGCTCGCTTGCTGGAACACAGGGGCCTTTTAAGTTGAGCGTGCGCACTGCATGGGAAATAGCGGCCCTGGAGGATGT TAGACTTGCTCCCTCTCCAAGACAGCAGCAGCCTGCACCTGCCCCGTGTGTGTGGCCGGCCTCCTCCTCACCCTTCCCGGCCCCCGGCCAAGGACCCAGG CGCTGCATACAGGGGAGGGGCGCACCCCACAGCTGGGGCCGGTTTTCCTCAGCTCTAGGCTGTTCTGTAGCTTATCTGCCCCTCCCCCACTTTCAAGACA GATGAGCAGGAGCTTGGGTCTCTCTCGGCCCCTGTCTGTTCCCAGCCCCTGCAGATTCTGAGCAAAGGCCCTGGGTAAGAAGGGTGGGAGTGGGGCCTTT GCCAGCAGAGCCAGGGCAGGGCGAGCTGCAGGAATCACCCCTCTGCCCCTGCAGCTGGAATGTGCCACAGAGGCCCCACCTGAAGGGTGGATGTGCTGGA GGGGTGGCCCAGAGCCATACTGCGTCCACCCTGAGCTCGGGGACAGGTGACAGTGGCTGCTCTGGGAAGGGGCTTTTAGATGTAACCTACAATTCAGTTA GGCTAGAGACAGATGCTGGTGGAGGAAGGGCTGGGCCACCAGGGATCACAGACCACAGGAAGATGGGAGGTGGAAGCAGAGGCCCTGCCCCCACCCCTTC CTGTCTCACTCTTCTGTCTTGTCCCCACCCATGCGCCTTCGTGCCTGAGACCAGGGTGGCCACACAGGCAGGGCCTGGCTCCAGTCTCATCCTCCCATTG CCCAGTGAGCCCTGCTCTTCTCTCCCCAGCCCCCTCCCACCGCTGCCTCGTAGAGTGACCTCGGACAGAGCCCCCCTAGCAATACAGGGAGGCTCCCGGG GCCTGGACAGGCGGGCTCGGAGGCTACCCGCTGTGGCCGGTGCCAGCTGCCCTTGCAGGGTGGGTGAGCTCTCAGGCCGAGAGCCTTATTTACCTAGTGC AAAAACTGTAAAAGTGTACAGACTCTTCACAGATTTTTATCTTAATTGCAAGTCTGCCGATTTTGTAAATGTTCTTGGTGTTTGACTGTAATGTAACTAT CTCACCTAATGGTTGTACATATCCTTTGGTCCTGGTGCTGCCGAGGGCTGGCCGGGACTGCTGCTCTCCCAAGGGTTTTATTTTATTTCTGAATCTAGAG AACAGTATTGGGCAGGAGGAAAAGGCTTGGTGTCTGCGGGGGGTGTCTTCCCTGCCTGTGGCATTTGTGTGTTGGCTTTGCAGCTGCTGTCTGAGTAGTG GCCACTGGGGTGCCTTCACTGGGCCAGTCAACGGGGGGCTCCTGCCCAGGCCACAGAGAACCTGAGTTCCCGGGAGCTGGGCCCTGCCTGCAGCCAGGGC TGGGGTTGCCAGAGGCCCTGGAGGGAAGGACAGTCCCTGCTGGGGAAGAACAGCCCCGGGGCCCCCTGGTCACCGAGACTCAGCCTCTGCTGGAGAAAGC CACGCCCTCCCTGCTAGCACAGAGGCCTGACTGACTTTTTTGCTTAACTTCCATGTTCTGGGTGATGGAAACTGCCAAACCTCCTGTCAGTGAGGACTCT TTCCGACTGCCCAGAAAGTGGGGGTGGAGGACCGAGGCTACAGCTCCACACGCCCCGGTCCCCCAGAGCATCTGCCCCAGGTACACCTCCCCCTGCGCCC CGCACGACTGCGGGAGCCAGACTGTCCAGGGAAACAGCCTCTCTCTTTTCTACACACTCAGCCACAAAGCCCCCCAGCTCCCACACCGCGTCCCAGCTCC CCTCTTTTGTAAGTATGTGAAAAGGAAAAAATGCAAACGTTGGAGTTTGGGCTGGAGCTCCTCCCTCCAGCTGCGACTTTTAACTATGTAATAATGTACA GAGGAAGCTGTTGGTGTTCTAAGACTCTGTGTGGCTGTGCAATTTCTGTACATTTGCAATTAGAAATATTAAAGATTTATTTAGCTATTTTAAGCCCGAC

DAB2IP.F3 (forward primer)
DAB2IP.R3 (reverse primer)
Single exon skipping

Frame 0

PAAELTGSVCTTGRAALAKNSALPSSTCEPPLD SEPGALHTPHPGPGPGPTTEAEAAGTALAPQVPR RVAGPLAEALPRPSEMGAGGASFRALAWASLPL LGPPACALCEDTLCCGESPQERPGSRRSLPGSL SEKSPSMEPSAATPFRVTGFLSRRLKGSIKRTKS QPKLDRNHSFRHILPGFRSAAAAAADNERSHLM PRLKESRSHESLLSPSSAVEALDLSMEEEVVIK PVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDK WMENLRRAVHPNKDNSRRVEHILKLWVIEAKDL PAKKKYLCELCLDDVLYARTTGKLKTDNVFWGE HFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLG LVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG PMIRIKARYQTITILPMEMYKEFAEHITNHYLG LCAALEPILSAKTKEEMASALVHILQSTGKVKDF LTDLMMSEVDRCGDNEHLIFRENTLATKAIEEY LKLVGQKYLQDALGEFIKALYESDENCEVDPSK CSAADLPEHQGNLKMCCELAFCKIINSYCVFPRE LKEVFASWRQECSSRGRPDISERLISASLFLRF LCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVT QNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFL LEISNPETLSNTAGFEGYIDLGRELSSLHSLLW EAVSQLEQSIVSKLGPLPRILRDVHTALSTPGS GQLPGTNDLASTPGSGSSSISAGLQKMVIENDLS GLIDFTRLPSPTPENKDLFFVTRSSGVQPSPAR SSSYSEANEPDLQMANGGKSLSMVDLQDARTLD GEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPV NLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAP LSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS SHSNSEELAAAAKLGSFSTAAEELARRPGELARR QMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPP PPPPAPRGRTPPNLLSTLQYPRPSSGTLASASP DWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPS PVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPH RDRLRSKDELSQAEKDLAVLQDKLRISTKKLEE YETLFKCQEETTQKLVLEYQARLEEGEERLRRQQ EDKDIQMKGIISRLMSVEEELKKDHAEMQAAVD SKQKIIDAQEKRIASLDAANARLMSALTQLKES MH*KQKPACSLAGTQGPFKLSVRTAWEIAALEDV RLAPSPRQQQPAPAPCVWPASSSPFPAPGQGPR RCIQGRGAPHSWGRFSSALGCSVAYLPLPHFQD R*AGAWVSLGPCLFPAPADSEQRPWVRRVGVGPL PAEPGQGELQESPLCPCSWNVPQRPHLKGGCAG GVAQSHTASTLSSGTGDSGCSGKGLLDVTYNSV RLETDAGGGRAGPPGITDHRKMGGGSRGPAPTPS CLTLLSCPHPCAFVPETRVATQAGPGSSLILPL PSEPCSSLPSPLPPLPRRVTSDRAPLAIQGGSR GLDRRARRLPAVAGASCPCRVGELSGREPYLPSA KTVKVYRLFTDFYLNCKSADFVNVLGV*L*CNY LT*WLYISFGPGAAEGWPGLLLSQGFYFISESR EQYWAGGKGLVSAGGVFPACGICVLALQLLSE*W PLGCLHWASQRGAPAQATENLSSRELGPACSQG WGCQRPWREGQSLLGKNSPGAPWSPRLSLCWRK PRPPC*HRGLTDFFA*LPCSG*WKLPNLLSVRTL SDCPESGGGGPRLQLHTPRSPRASAPGTPPPAP RTTAGARLSRETASLFSTHSATKPPSSHTASQL PSFVSM*KGKNANVGVWAGAPPSSCDF*LCNNVQ RKLLVF*DSVWLCNFCTFAIRNIKDLFSYFKPD

Frame 1

QRPN*LVLSVRLGEQLSLKIAPCPARPASRRWI LSREPCTPLTPGLARDRPRRRRPRAPRWPHRCR GGWQARWPRHCRGRPRWELAVPPSAPSPGPPCPC WGLQPARSARTRSAAESRLKKGRALGAACLAAF PRRAPAWSPRPPRRSGSRASSAAASRAPSSAPR ASPSWTATTASATSCRGSGAPPPPPRTMRGPI*C RG*RSLAPTSPCSAPAVRWRRWTSAWRKRWSSS PCTAASLARTTASR*RRHQEASAFPAGLQLSGI SGWRTSGERCIPTRTTAGVWSTS*SCG*SRPRTC QPRRSTCASCAWTMCSMPAPRASSRRTMFSGAS TSSSTTCRLCARSLSTCTGRPTRRRRRSATVTW AW*AYLLPRWPGGSSWRSGTRW*RPTPRAARALD P*SASRRATKPSPSCPWRCTKSSLSTSPTTTWG CVQPSSPSSVPRPRRRWHLPWCTSCRARAR*RT S*QT**CQRWTAAGTTSTSSSGRTHWPPRPLRST SS*WARSTCRTP*VSSSKRCMSQMRTAKWIPAS ARPLTSQSTRATSRCAASWPSARSSTPTVSSHG S*KRCLPRGGRSAAVAAARTSVSGSSAPPSSCAS SAQPSCRPHSSTCCRSTLMTALPAPSPSSPRSP RTWPTLPNLAARRNTCPS*TSS*SMSGPTCSAS CWRSPTPRPSPIQPASRATSTWAASSPACTHCSG RPSASWSRA*YPNWDPCLGS*GTSTQH*APQVA GSSQGPMTWPPHRALAAAASQLGCRRW*LRTIF PV**ISPGYRLQPPKTRTCFLSQGPPGSSPHLPA ARVTRKPTSLIFRWPTVARASPWWTSRTPARWM GRQAPRRAPTSSPQMGRPLQLSWWPGGRPGQPQ *TWQGWPRCGGQARHQPHQAPPRARQAGPSCWHR SPSRTLCTRWRLACRCHPVALATQALRATAP*A HTATARSWRLLPSWEVSALPRRSWLGGPVSWHG DRCH*LKKAGSPRCHGRTVLAPRGGSTSLRPHPR RHLLPPAAGRPPTC*APCSTQDPQAEPWRRPHL IGWAPVPA*GSSPLPPRGTAQN*SHGQCTSRAL HL*APMPWTAQPLGS*P*TRSC*KTRAWAQTPPT GIG*GVRTSSAKQKRTWRCCRTSCESPPRSWRS MRPCSSARRRRRRSWCWSTRHGWRRARSGCGGS RRTRTSR*RASSAG*CPWRKN*RRTTQRCKRLWT PNRRSLMPRRSALPRWMPPMPAS*VP*PS*KRV CIRNKSPLARLLEHRGLLS*ACALHGK*RPWRM LDLLPLQDSSSLHLPRVCGRPPPHPSRPPAKDPG AAYRGGAHPTAGAGFPQL*AVL*LICPSPTFKT DEQELGSLSAPVCSQPLQILSKGPG*EGWEWGL CQQSQGRASCRNHPSAPAAGMCHRGPT*RVDVLE GWPRAILRPP*ARGQVTVAALGRGF*M*PTIQL G*RQMLVEEGLGHQGSQTTGRWEVEAEALPPPL PVSLFCLVPTHAPSCLRPGWPHRQGLAPVSSSHC PVSPALLSPAPSHRCLVE*PRTEPP*QYREAPG AWTGGLGGYPLWPVPAALAGWVSSQAESLIYLV QKL*KCTDSSQIFILIASLPIL*MFLVFDCNVTI SPNGCTYPLVLVLPRAGRDCCSPKGFILFLNLE NSIGQEEKAWCLRGVSSLPVAFVCWLCSCCLSS GHWGAFTGPVNGGLLPRPQRT*VPGSWALPAARA GVARGPGGKDSPCWGRTAPGPPGHRDSASAGES HALPASTEA*LTFLLNFHVLGDGNCQTSCQ*GL FPTAQKVGVEDRGYSSTRPGPPEHLPQVHLPLRP ARLREPDCPGKQPLSFLHTQPQSPPAPTPRPSS PLL*VCEKEKMQTLEFGLELLPPAATFNYVIMY RGSCWCSKTLCGCAISVHLQLEILKIYLAILSP

Frame 2

SGRINWFCLYDWESSSR*K*RPAQLDLRAAVGF *AGSPAHPSPRAWPGTDHGGGGRGHRAGPTGAA EGGRPAGRGTAEAVRDGSWRCLLPRPRLGLPAP AGASSLRALRGHALLRRVASRKAGLSAQPAWQPF REEPQHGALGRHAVPGHGLPQPPPQGLHQAHQE PAQAGPQPQLPPHPAGVPERRRRRRGQ*EVPSD AEAEGVSLPRVPAQPQQCGGGAGPQHGGRGGHQA RAQQHPWPGLLLRGDDVIRKQVLFLPVCS*AG* VDGEPPASGASQQGQQPACGAHPEAVGDRGQGP ASQEEVPVRAVPGRCALCPHHGQAQDGQCFLGRA LRVPQLAASAHGHCPPVPGDRQEEEEGAQQLPG PGEPTCCLGGRAAVRGEVVPGGDAQPQGRQGPW THDPHQGALPNHHHPAHGDVQRVR*AHHQPLPGA VCSPRAHPQCQDQGGDGICPGAHPAEHGQGEGL PDRPDDVRGGPLRGQRAPHLPGEHTGHQGH*GV PQASGPEVPAGRPR*VHQSAV*VR*ELRSGSQQV LGR*PPRAPGQPQDVLRAGLLQDHQLLLCLPTG VERGVCLVEAGVQQSRPPGHQ*AAHQRLPLPAL PLPSHHVALTLQPAAGVP**PHCPHPHPHRQGHP EPGQLCQIWQQGGIHVLHEPVPRA*VDQHAALP AGDLQPRDPLQYSRLRGLHRPGPRALQPALTAL GGRQPAGAEHSIQTGTPASDPEGRPHSTEHPR*R AAPRDQ*PGLHTGLWQQQHLSWAAEDGD*ERSF RSDRFHPVTVSNPRKQGLVFCHKVLRGPALTCP QLELLGSQRA*SSDGQRWQEPLHGGPPGRPHAGW GGRLPGGPRRPPHRWAGRCSSAGGRVAGPGNPS EPGRAGHGAAGRPDTNHTRHLRGRARPAPAVGT ALLPEPCVPDGGWPAAVTPWPWRLRL*GPQLPEL TQQQRGVGGCCQAGKFQHCRGGAGSAAR*AGTA TDVTD*KRRAAHGATAEQCWPPEEDRPASAPTP AATSCPPRPDAPQPAEHPAVPKTLKRNPGVGLT* LGGPQYPPEAAVLFLQGGQPRTEATGSAQAGPF TCEPQCPGPHSRLALDHERAVVRRRGPGPRPPP QG*AKE*GRAQPSRKGPGGAAGQAANLHQEAGGV *DPVQVPGGDDAEAGAGVPGTAGGGRGAAAAAA GGQGHPDEGHHQQVDVRGGRTEEGPRRDASGCG LQTEDH*CPGEAHCLVGCRQCPPHECPDPAEREY ALETKARLLACWNTGAF*VERAHCMGNSGPGGC *TCSLSKTAAACTCPVCVAGLLLTLPGPRPRTQ ALHTGEGRTPQLGPVFLSSRLFCSLSAPPPLSRQ MSRSLGLSRPLSVPSPCRF*AKALGKKGGSGAF ASRARAGRAAGITPLPLQLECATEAPPEGWMCW RGGPEPYCVHPELGDR*QWLLWEGAFRCNLQFS* ARDRCWWRKGWATRDHRPQEDGRWKQRPCPHPF LSHSSVLSPPMRLRA*DQGGHTGRAWLQSHPPI AQ*ALLFSPQPPPTAAS*SDLGQSPPSNTGRLPG PGQAGSEATRCGRCQLPLQGG*ALRPRALFT*C KNCKSVQTLHRFLS*LQVCRFCKCSWCLTVM*L SHLMVVHILWSWCCRGLAGTAALPRVLFYF*I*R TVLGRRKRLGVCGGCLPCLWHLCVGFAAAV*VV ATGVPSLGQSTGGSCPGHREPEFPGAGPCLQPG LGLPEALEGRTVPAGEEQPRGPLVTETQPLLEKA TPSLLAQRPD*LFCLTSMFWVMETAKPPVSEDS FRLPRKWGWRTEATAPHAPVPQSICPRYTSPCA PHDCGSQTVQGNSLSLFYTLSHKAPQLPHRVPAP LFCKYVKRKKCKRWSLGWSSSLQLRLLTM**CT EEAVGVLRLCVAVQFLYICN*KY*RFI*LF*AR