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Sequences

Sequence HMMR.eAug05

HMMR.F1 (forward primer)
HMMR.R1 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence HMMR.cAug05

GGGAAGTGCGCTTGCGCAAATGCTAGGTTACACTTGAGTAACTCCGGGAATGACTGGGTGGGTGGGGCGGGGAACAGTAACGGTCTCCTATTGGATGGCA GCCTAAACTCGCAGGCCAGCTAATTGGACGCAATCAGAACCCAGCATTCTTTCTTCGTGTTCCTGTGCGGGATTGGTGTGCCCAGGGGTTTGGCTTTCCA ATTGGCTAACGCCGGGGTGGGTGGGGAATGTGGGGAGATTTGAATTTGAAACCGGTAGGGAGTGATAATCCGCATTCAGTTGTCGAGGAGTGCCAGTCAC CTTCAGTTTCTGGAGCTGGCCGTCAACATGTCCTTTCCTAAGGCGCCCTTGAAACGATTCAATGACCCTTCTGGTTGTGCACCATCTCCAGGTGCTTATG ATGTTAAAACTTTAGAAGTATTGAAAGGACCAGTATCCTTTCAGAAATCACAAAGATTTAAACAGCAAAAAGAATCTAAACAAAATCTTAATGTTGACAA AGATACTACCTTGCCTGCTTCAGCTAGAAAAGTTAAGTCTTCGGAATCAAAGATTCGTGTTCTTCTACAGGAACGTGGTGCCCAGGACAGGCGGATCCAG GATCTGGAAACTGAGTTGGAAAAGATGGAAGCAAGGCTAAATGCTGCACTAAGGGAAAAAACATCTCTCTCTGCAAATAATGCTACACTGGAAAAACAAC TTATTGAATTGACCAGGACTAATGAACTACTAAAATCTAAGTTTTCTGAAAATGGTAACCAGAAGAATTTGAGAATTCTAAGCTTGGAGTTGATGAAACT TAGAAACAAAAGAGAAACAAAGATGAGGGGTATGATGGCTAAGCAAGAAGGCATGGAGATGAAGCTGCAGGTCACCCAAAGGAGTCTCGAAGAGTCTCAA GGGAAAATAGCCCAACTGGAGGGAAAACTTGTTTCAATAGAGAAAGAAAAGATTGATGAAAAATCTGAAACAGAAAAACTCTTGGAATACATCGAAGAAA TTAGTTGTGCTTCAGATCAAGTGGAAAAATACAAGCTAGATATTGCCCAGTTAGAAGAAAATTTGAAAGAGAAGAATGATGAAATTTTAAGCCTTAAGCA GTCTCTTGAGGAGAATATTGTTATATTATCTAAACAAGTAGAAGATCTAAATGTGAAATGTCAGCTGCTTGAAAAAGAAAAAGAAGACCATGTCAACAGG AATAGAGAACACAACGAAAATCTAAATGCAGAGATGCAAAACTTAAAACAGAAGTTTATTCTTGAACAACAGGAACGTGAAAAGCTTCAACAAAAAGAAT TACAAATTGATTCACTTCTGCAACAAGAGAAAGAATTATCTTCGAGTCTTCATCAGAAGCTCTGTTCTTTTCAAGAGGAAATGGTTAAAGAGAAGAATCT GTTTGAGGAAGAATTAAAGCAAACACTGGATGAGCTTGATAAATTACAGCAAAAGGAGGAACAAGCTGAAAGGCTGGTCAAGCAATTGGAAGAGGAAGCA AAATCTAGAGCTGAAGAATTAAAACTCCTAGAAGAAAAGCTGAAAGGGAAGGAGGCTGAACTGGAGAAAAGTAGTGCTGCTCATACCCAGGCCACCCTGC TTTTGCAGGAAAAGTATGACAGTATGGTGCAAAGCCTTGAAGATGTTACTGCTCAATTTGAAAGCTATAAAGCGTTAACAGCCAGTGAGATAGAAGATCT TAAGCTGGAGAACTCATCATTACAGGAAAAAGCGGCCAAGGCTGGGAAAAATGCAGAGGATGTTCAGCATCAGATTTTGGCAACTGAGAGCTCAAATCAA GAATATGTAAGGATGCTTCTAGATCTGCAGACCAAGTCAGCACTAAAGGAAACAGAAATTAAAGAAATCACAGTTTCTTTTCTTCAAAAAATAACTGATT TGCAGAACCAACTCAAGCAACAGGAGGAAGACTTTAGAAAACAGCTGGAAGATGAAGAAGGAAGAAAAGCTGAAAAAGAAAATACAACAGCAGAATTAAC TGAAGAAATTAACAAGTGGCGTCTCCTCTATGAAGAACTATATAATAAAACAAAACCTTTTCAGCTACAACTAGATGCTTTTGAAGTAGAAAAACAGGCA TTGTTGAATGAACATGGTGCAGCTCAGGAACAGCTAAATAAAATAAGAGATTCATATGCTAAATTATTGGGTCATCAGAATTTGAAACAAAAAATCAAGC ATGTTGTGAAGTTGAAAGATGAAAATAGCCAACTCAAATCGGAAGTATCAAAACTCCGCTGTCAGCTTGCTAAAAAAAAACAAAGTGAGACAAAACTTCA AGAGGAATTGAATAAAGTTCTAGGTATCAAACACTTTGATCCTTCAAAGGCTTTTCATCATGAAAGTAAAGAAAATTTTGCCCTGAAGACCCCATTAAAA GAAGGCAATACAAACTGTTACCGAGCTCCTATGGAGTGTCAAGAATCATGGAAGTAAACATCTGAGAAACCTGTTGAAGATTATTTCATTCGTCTTGTTG TTATTGATGTTGCTGTTATTATATTTGACATGGGTATTTTATAATGTTGTATTTAATTTTAACTGCCAATCCTTAAATATGTGAAAGGAACATTTTTTAC CAAAGTGTCTTTTGACATTTTATTTTTTCTTGCAAATACCTCCTCCCTAATGCTCACCTTTATCACCTCATTCTGAACCCTTTCGCTGGCTTTCCAGCTT AGAATGCATCTCATCAACTTAAAAGTCAGTATCATATTATTATCCTCCTGTTCTGAAACCTTAGTTTCAAGAGTCTAAACCCCAGATTCTTCAGCTTGAT CCTGGAGGTCTTTTCTAGTCTGAGCTTCTTTAGCTAGGCTAAAACACCTTGGCTTGTTATTGCCTCTACTTTGATTCTGATAATGCTCACTTGGTCCTAC CTATTATCCTTCTACTTGTCCAGTTCAAATAAGAAATAAGGACAAGCCTAACTTCATAGAAACCTCTCTATTTTTAATCAGTTGTTTAATAATTTACAGG TTCTTAGGCTCCATCCTGTTTGTATGAAATTATAATCTGTGGATTGGCCTTTAAGCCTGCATTCTTAACAAACTCTTCAGTTAATTCTTAGATACACTAA AAATCTGAGAAACTCTACATGTAACTATTTCTTCAGAGTTTGTCATATACTGCTTGTCATCTGCATGTCTACTCAGCATTTGATTAACATTTGTGTAATA TGAAATAAAATTACACAGTAAGTCATTTAACCAATTAA

HMMR.F1 (forward primer)
HMMR.R1 (reverse primer)
Single exon skipping

Frame 0

GKCACANARLHLSNSGNDWVGGAGNSNGLLLDG SLNSQAS*LDAIRTQHSFFVFLCGIGVPRGLAFQ LANAGVGGECGEI*I*NR*GVIIRIQLSRSASH LQFLELAVNMSFPKAPLKRFNDPSGCAPSPGAY DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDK DTTLPASARKVKSSESKIRVLLQERGAQDRRIQ DLETELEKMEARLNAALREKTSLSANNATLEKQ LIELTRTNELLKSKFSENGNQKNLRILSLELMKL RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNR NREHNENLNAEMQNLKQKFILEQQEREKLQQKE LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNL FEEELKQTLDELDKLQQKEEQAERLVKQLEEEA KSRAEELKLLEEKLKGKEAELEKSSAAHTQATL LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL KLENSSLQEKAAKAGKNAEDVQHQILATESSNQ EYVRMLLDLQTKSALKETEIKEITVSFLQKITD LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA LLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQ EELNKVLGIKHFDPSKAFHHESKENFALKTPLK EGNTNCYRAPMECQESWK*TSEKPVEDYFIRLV VIDVAVIIFDMGIL*CCI*F*LPILKYVKGTFFT KVSFDILFFLANTSSLMLTFITSF*TLSLAFQL RMHLINLKVSIILLSSCSETLVSRV*TPDSSA* SWRSFLV*ASLARLKHLGLLLPLL*F**CSLGPT YYPSTCPVQIRNKDKPNFIETSLFLISCLIIYR FLGSILFV*NYNLWIGL*ACILNKLFS*FLDTL KI*ETLHVTISSEFVIYCLSSACLLSI*LTFV*Y EIKLHSKSFNQL

Frame 1

GSALAQMLGYT*VTPGMTGWVGRGTVTVSYWMA A*TRRPANWTQSEPSILSSCSCAGLVCPGVWLS NWLTPGWVGNVGRFEFETGRE**SAFSCRGVPVT FSFWSWPSTCPFLRRP*NDSMTLLVVHHLQVLM MLKL*KY*KDQYPFRNHKDLNSKKNLNKILMLT KILPCLLQLEKLSLRNQRFVFFYRNVVPRTGGSR IWKLSWKRWKQG*MLH*GKKHLSLQIMLHWKNN LLN*PGLMNY*NLSFLKMVTRRI*EF*AWS**N LETKEKQR*GV*WLSKKAWR*SCRSPKGVSKSLK GK*PNWRENLFQ*RKKRLMKNLKQKNSWNTSKK LVVLQIKWKNTS*ILPS*KKI*KRRMMKF*ALS SLLRRILLYYLNK*KI*M*NVSCLKKKKKTMSTG IENTTKI*MQRCKT*NRSLFLNNRNVKSFNKKN YKLIHFCNKRKNYLRVFIRSSVLFKRKWLKRRI CLRKN*SKHWMSLINYSKRRNKLKGWSSNWKRKQ NLELKN*NS*KKS*KGRRLNWRKVVLLIPRPPC FCRKSMTVWCKALKMLLLNLKAIKR*QPVR*KI LSWRTHHYRKKRPRLGKMQRMFSIRFWQLRAQIK NM*GCF*ICRPSQH*RKQKLKKSQFLFFKK*LI CRTNSSNRRKTLENSWKMKKEEKLKKKIQQQN* LKKLTSGVSSMKNYIIKQNLFSYN*MLLK*KNRH C*MNMVQLRNS*IK*EIHMLNYWVIRI*NKKSS ML*S*KMKIANSNRKYQNSAVSLLKKNKVRQNF KRN*IKF*VSNTLILQRLFIMKVKKILP*RPH*K KAIQTVTELLWSVKNHGSKHLRNLLKIISFVLL LLMLLLLYLTWVFYNVVFNFNCQSLNM*KEHFL PKCLLTFYFFLQIPPP*CSPLSPHSEPFRWLSSL ECISST*KSVSYYYPPVLKP*FQESKPQILQLD PGGLF*SELL*LG*NTLACYCLYFDSDNAHLVL PIILLLVQFK*EIRTSLTS*KPLYF*SVV**FTG S*APSCLYEIIICGLAFKPAFLTNSSVNS*IH* KSEKLYM*LFLQSLSYTACHLHVYSAFD*HLCN MK*NYTVSHLTN*

Frame 2

EVRLRKC*VTLE*LRE*LGGWGGEQ*RSPIGWQ PKLAGQLIGRNQNPAFFLRVPVRDWCAQGFGFP IG*RRGGWGMWGDLNLKPVGSDNPHSVVEECQS PSVSGAGRQHVLS*GALETIQ*PFWLCTISRCL* C*NFRSIERTSILSEITKI*TAKRI*TKS*C*Q RYYLACFS*KS*VFGIKDSCSSTGTWCPGQADP GSGN*VGKDGSKAKCCTKGKNISLCK*CYTGKTT Y*IDQD**TTKI*VF*KW*PEEFENSKLGVDET *KQKRNKDEGYDG*ARRHGDEAAGHPKESRRVS RENSPTGGKTCFNRERKD**KI*NRKTLGIHRRN *LCFRSSGKIQARYCPVRRKFEREE**NFKP*A VS*GEYCYII*TSRRSKCEMSAA*KRKRRPCQQ E*RTQRKSKCRDAKLKTEVYS*TTGT*KASTKRI TN*FTSATRERIIFESSSEALFFSRGNG*REES V*GRIKANTG*A**ITAKGGTS*KAGQAIGRGS KI*S*RIKTPRRKAEREGG*TGEK*CCSYPGHPA FAGKV*QYGAKP*RCYCSI*KL*SVNSQ*DRRS *AGELIITGKSGQGWEKCRGCSASDFGN*ELKS RICKDASRSADQVSTKGNRN*RNHSFFSSKNN*F AEPTQATGGRL*KTAGR*RRKKS*KRKYNSRIN *RN*QVASPL*RTI**NKTFSATTRCF*SRKTG IVE*TWCSSGTAK*NKRFIC*IIGSSEFETKNQA CCEVER*K*PTQIGSIKTPLSAC*KKTK*DKTS RGIE*SSRYQTL*SFKGFSS*K*RKFCPEDPIK RRQYKLLPSSYGVSRIMEVNI*ETC*RLFHSSCC Y*CCCYYI*HGYFIMLYLILTANP*ICERNIFY QSVF*HFIFSCKYLLPNAHLYHLILNPFAGFPA *NASHQLKSQYHIIILLF*NLSFKSLNPRFFSLI LEVFSSLSFFS*AKTPWLVIASTLILIMLTWSY LLSFYLSSSNKK*GQA*LHRNLSIFNQLFNNLQ VLRLHPVCMKL*SVDWPLSLHS*QTLQLILRYTK NLRNSTCNYFFRVCHILLVICMSTQHLINICVI *NKITQ*VI*PI

Sequence HMMR.bAug05

GGGAAGTGCGCTTGCGCAAATGCTAGGTTACACTTGAGTAACTCCGGGAATGACTGGGTGGGTGGGGCGGGGAACAGTAACGGTCTCCTATTGGATGGCA GCCTAAACTCGCAGGCCAGCTAATTGGACGCAATCAGAACCCAGCATTCTTTCTTCGTGTTCCTGTGCGGGATTGGTGTGCCCAGGGGTTTGGCTTTCCA ATTGGCTAACGCCGGGGTGGGTGGGGAATGTGGGGAGATTTGAATTTGAAACCGGTAGGGAGTGATAATCCGCATTCAGTTGTCGAGGAGTGCCAGTCAC CTTCAGTTTCTGGAGCTGGCCGTCAACATGTCCTTTCCTAAGGCGCCCTTGAAACGATTCAATGACCCTTCTGGTTGTGCACCATCTCCAGGTGCTTATG ATGTTAAAACTTTAGAAGTATTGAAAGGACCAGTATCCTTTCAGAAATCACAAAGATTTAAACAGCAAAAAGAATCTAAACAAAATCTTAATGTTGACAA AGATACTACCTTGCCTGCTTCAGCTAGAAAAGTTAAGTCTTCGGAATCAAAGGAATCTCAAAAGAATGATAAAGATTTGAAGATATTAGAGAAAGAGATT CGTGTTCTTCTACAGGAACGTGGTGCCCAGGACAGGCGGATCCAGGATCTGGAAACTGAGTTGGAAAAGATGGAAGCAAGGCTAAATGCTGCACTAAGGG AAAAAACATCTCTCTCTGCAAATAATGCTACACTGGAAAAACAACTTATTGAATTGACCAGGACTAATGAACTACTAAAATCTAAGTTTTCTGAAAATGG TAACCAGAAGAATTTGAGAATTCTAAGCTTGGAGTTGATGAAACTTAGAAACAAAAGAGAAACAAAGATGAGGGGTATGATGGCTAAGCAAGAAGGCATG GAGATGAAGCTGCAGGTCACCCAAAGGAGTCTCGAAGAGTCTCAAGGGAAAATAGCCCAACTGGAGGGAAAACTTGTTTCAATAGAGAAAGAAAAGATTG ATGAAAAATCTGAAACAGAAAAACTCTTGGAATACATCGAAGAAATTAGTTGTGCTTCAGATCAAGTGGAAAAATACAAGCTAGATATTGCCCAGTTAGA AGAAAATTTGAAAGAGAAGAATGATGAAATTTTAAGCCTTAAGCAGTCTCTTGAGGAGAATATTGTTATATTATCTAAACAAGTAGAAGATCTAAATGTG AAATGTCAGCTGCTTGAAAAAGAAAAAGAAGACCATGTCAACAGGAATAGAGAACACAACGAAAATCTAAATGCAGAGATGCAAAACTTAAAACAGAAGT TTATTCTTGAACAACAGGAACGTGAAAAGCTTCAACAAAAAGAATTACAAATTGATTCACTTCTGCAACAAGAGAAAGAATTATCTTCGAGTCTTCATCA GAAGCTCTGTTCTTTTCAAGAGGAAATGGTTAAAGAGAAGAATCTGTTTGAGGAAGAATTAAAGCAAACACTGGATGAGCTTGATAAATTACAGCAAAAG GAGGAACAAGCTGAAAGGCTGGTCAAGCAATTGGAAGAGGAAGCAAAATCTAGAGCTGAAGAATTAAAACTCCTAGAAGAAAAGCTGAAAGGGAAGGAGG CTGAACTGGAGAAAAGTAGTGCTGCTCATACCCAGGCCACCCTGCTTTTGCAGGAAAAGTATGACAGTATGGTGCAAAGCCTTGAAGATGTTACTGCTCA ATTTGAAAGCTATAAAGCGTTAACAGCCAGTGAGATAGAAGATCTTAAGCTGGAGAACTCATCATTACAGGAAAAAGCGGCCAAGGCTGGGAAAAATGCA GAGGATGTTCAGCATCAGATTTTGGCAACTGAGAGCTCAAATCAAGAATATGTAAGGATGCTTCTAGATCTGCAGACCAAGTCAGCACTAAAGGAAACAG AAATTAAAGAAATCACAGTTTCTTTTCTTCAAAAAATAACTGATTTGCAGAACCAACTCAAGCAACAGGAGGAAGACTTTAGAAAACAGCTGGAAGATGA AGAAGGAAGAAAAGCTGAAAAAGAAAATACAACAGCAGAATTAACTGAAGAAATTAACAAGTGGCGTCTCCTCTATGAAGAACTATATAATAAAACAAAA CCTTTTCAGCTACAACTAGATGCTTTTGAAGTAGAAAAACAGGCATTGTTGAATGAACATGGTGCAGCTCAGGAACAGCTAAATAAAATAAGAGATTCAT ATGCTAAATTATTGGGTCATCAGAATTTGAAACAAAAAATCAAGCATGTTGTGAAGTTGAAAGATGAAAATAGCCAACTCAAATCGGAAGTATCAAAACT CCGCTGTCAGCTTGCTAAAAAAAAACAAAGTGAGACAAAACTTCAAGAGGAATTGAATAAAGTTCTAGGTATCAAACACTTTGATCCTTCAAAGGCTTTT CATCATGAAAGTAAAGAAAATTTTGCCCTGAAGACCCCATTAAAAGAAGGCAATACAAACTGTTACCGAGCTCCTATGGAGTGTCAAGAATCATGGAAGT AAACATCTGAGAAACCTGTTGAAGATTATTTCATTCGTCTTGTTGTTATTGATGTTGCTGTTATTATATTTGACATGGGTATTTTATAATGTTGTATTTA ATTTTAACTGCCAATCCTTAAATATGTGAAAGGAACATTTTTTACCAAAGTGTCTTTTGACATTTTATTTTTTCTTGCAAATACCTCCTCCCTAATGCTC ACCTTTATCACCTCATTCTGAACCCTTTCGCTGGCTTTCCAGCTTAGAATGCATCTCATCAACTTAAAAGTCAGTATCATATTATTATCCTCCTGTTCTG AAACCTTAGTTTCAAGAGTCTAAACCCCAGATTCTTCAGCTTGATCCTGGAGGTCTTTTCTAGTCTGAGCTTCTTTAGCTAGGCTAAAACACCTTGGCTT GTTATTGCCTCTACTTTGATTCTGATAATGCTCACTTGGTCCTACCTATTATCCTTCTACTTGTCCAGTTCAAATAAGAAATAAGGACAAGCCTAACTTC ATAGAAACCTCTCTATTTTTAATCAGTTGTTTAATAATTTACAGGTTCTTAGGCTCCATCCTGTTTGTATGAAATTATAATCTGTGGATTGGCCTTTAAG CCTGCATTCTTAACAAACTCTTCAGTTAATTCTTAGATACACTAAAAATCTGAGAAACTCTACATGTAACTATTTCTTCAGAGTTTGTCATATACTGCTT GTCATCTGCATGTCTACTCAGCATTTGATTAACATTTGTGTAATATGAAATAAAATTACACAGTAAGTCATTTAACCAATTAA

HMMR.F1 (forward primer)
HMMR.R1 (reverse primer)
Single exon skipping

Frame 0

GKCACANARLHLSNSGNDWVGGAGNSNGLLLDG SLNSQAS*LDAIRTQHSFFVFLCGIGVPRGLAFQ LANAGVGGECGEI*I*NR*GVIIRIQLSRSASH LQFLELAVNMSFPKAPLKRFNDPSGCAPSPGAY DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDK DTTLPASARKVKSSESKESQKNDKDLKILEKEI RVLLQERGAQDRRIQDLETELEKMEARLNAALR EKTSLSANNATLEKQLIELTRTNELLKSKFSENG NQKNLRILSLELMKLRNKRETKMRGMMAKQEGM EMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE ENLKEKNDEILSLKQSLEENIVILSKQVEDLNV KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQK FILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKE AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ FESYKALTASEIEDLKLENSSLQEKAAKAGKNA EDVQHQILATESSNQEYVRMLLDLQTKSALKET EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE EGRKAEKENTTAELTEEINKWRLLYEELYNKTK PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS YAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL RCQLAKKKQSETKLQEELNKVLGIKHFDPSKAF HHESKENFALKTPLKEGNTNCYRAPMECQESWK *TSEKPVEDYFIRLVVIDVAVIIFDMGIL*CCI* F*LPILKYVKGTFFTKVSFDILFFLANTSSLML TFITSF*TLSLAFQLRMHLINLKVSIILLSSCS ETLVSRV*TPDSSA*SWRSFLV*ASLARLKHLGL LLPLL*F**CSLGPTYYPSTCPVQIRNKDKPNF IETSLFLISCLIIYRFLGSILFV*NYNLWIGL* ACILNKLFS*FLDTLKI*ETLHVTISSEFVIYCL SSACLLSI*LTFV*YEIKLHSKSFNQL

Frame 1

GSALAQMLGYT*VTPGMTGWVGRGTVTVSYWMA A*TRRPANWTQSEPSILSSCSCAGLVCPGVWLS NWLTPGWVGNVGRFEFETGRE**SAFSCRGVPVT FSFWSWPSTCPFLRRP*NDSMTLLVVHHLQVLM MLKL*KY*KDQYPFRNHKDLNSKKNLNKILMLT KILPCLLQLEKLSLRNQRNLKRMIKI*RY*RKRF VFFYRNVVPRTGGSRIWKLSWKRWKQG*MLH*G KKHLSLQIMLHWKNNLLN*PGLMNY*NLSFLKM VTRRI*EF*AWS**NLETKEKQR*GV*WLSKKAW R*SCRSPKGVSKSLKGK*PNWRENLFQ*RKKRL MKNLKQKNSWNTSKKLVVLQIKWKNTS*ILPS* KKI*KRRMMKF*ALSSLLRRILLYYLNK*KI*M* NVSCLKKKKKTMSTGIENTTKI*MQRCKT*NRS LFLNNRNVKSFNKKNYKLIHFCNKRKNYLRVFI RSSVLFKRKWLKRRICLRKN*SKHWMSLINYSKR RNKLKGWSSNWKRKQNLELKN*NS*KKS*KGRR LNWRKVVLLIPRPPCFCRKSMTVWCKALKMLLL NLKAIKR*QPVR*KILSWRTHHYRKKRPRLGKMQ RMFSIRFWQLRAQIKNM*GCF*ICRPSQH*RKQ KLKKSQFLFFKK*LICRTNSSNRRKTLENSWKM KKEEKLKKKIQQQN*LKKLTSGVSSMKNYIIKQN LFSYN*MLLK*KNRHC*MNMVQLRNS*IK*EIH MLNYWVIRI*NKKSSML*S*KMKIANSNRKYQN SAVSLLKKNKVRQNFKRN*IKF*VSNTLILQRLF IMKVKKILP*RPH*KKAIQTVTELLWSVKNHGS KHLRNLLKIISFVLLLLMLLLLYLTWVFYNVVF NFNCQSLNM*KEHFLPKCLLTFYFFLQIPPP*CS PLSPHSEPFRWLSSLECISST*KSVSYYYPPVL KP*FQESKPQILQLDPGGLF*SELL*LG*NTLA CYCLYFDSDNAHLVLPIILLLVQFK*EIRTSLTS *KPLYF*SVV**FTGS*APSCLYEIIICGLAFK PAFLTNSSVNS*IH*KSEKLYM*LFLQSLSYTA CHLHVYSAFD*HLCNMK*NYTVSHLTN*

Frame 2

EVRLRKC*VTLE*LRE*LGGWGGEQ*RSPIGWQ PKLAGQLIGRNQNPAFFLRVPVRDWCAQGFGFP IG*RRGGWGMWGDLNLKPVGSDNPHSVVEECQS PSVSGAGRQHVLS*GALETIQ*PFWLCTISRCL* C*NFRSIERTSILSEITKI*TAKRI*TKS*C*Q RYYLACFS*KS*VFGIKGISKE**RFEDIRERD SCSSTGTWCPGQADPGSGN*VGKDGSKAKCCTKG KNISLCK*CYTGKTTY*IDQD**TTKI*VF*KW *PEEFENSKLGVDET*KQKRNKDEGYDG*ARRH GDEAAGHPKESRRVSRENSPTGGKTCFNRERKD* *KI*NRKTLGIHRRN*LCFRSSGKIQARYCPVR RKFEREE**NFKP*AVS*GEYCYII*TSRRSKC EMSAA*KRKRRPCQQE*RTQRKSKCRDAKLKTEV YS*TTGT*KASTKRITN*FTSATRERIIFESSS EALFFSRGNG*REESV*GRIKANTG*A**ITAK GGTS*KAGQAIGRGSKI*S*RIKTPRRKAEREGG *TGEK*CCSYPGHPAFAGKV*QYGAKP*RCYCS I*KL*SVNSQ*DRRS*AGELIITGKSGQGWEKC RGCSASDFGN*ELKSRICKDASRSADQVSTKGNR N*RNHSFFSSKNN*FAEPTQATGGRL*KTAGR* RRKKS*KRKYNSRIN*RN*QVASPL*RTI**NK TFSATTRCF*SRKTGIVE*TWCSSGTAK*NKRFI C*IIGSSEFETKNQACCEVER*K*PTQIGSIKT PLSAC*KKTK*DKTSRGIE*SSRYQTL*SFKGF SS*K*RKFCPEDPIKRRQYKLLPSSYGVSRIMEV NI*ETC*RLFHSSCCY*CCCYYI*HGYFIMLYL ILTANP*ICERNIFYQSVF*HFIFSCKYLLPNA HLYHLILNPFAGFPA*NASHQLKSQYHIIILLF* NLSFKSLNPRFFSLILEVFSSLSFFS*AKTPWL VIASTLILIMLTWSYLLSFYLSSSNKK*GQA*L HRNLSIFNQLFNNLQVLRLHPVCMKL*SVDWPLS LHS*QTLQLILRYTKNLRNSTCNYFFRVCHILL VICMSTQHLINICVI*NKITQ*VI*PI