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Sequences

Sequence LGALS9.jAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGG TTTGCTGTGAACTTTCAGACTGGCTTCAGTGGAAATGACATTGCCTTCCACTTCAACCCTCGGTTTGAAGATGGAGGGTACGTGGTGTGCAACACGAGGC AGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTCTGCTTCCTGGTGCAGAGCTCAGATTTCAA GCCAGTTCAAACCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGTGCAGAGCGCCCCTGGACAGATGTTCTCTAC TCCCGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGAGGGCTGTACCCATCCAAGTCCATCCTCCTG TCAGGCACTGTCCTGCCCAGTGCTCAGAGGTTCCACATCAACCTGTGCTCTGGGAACCACATCGCCTTCCACCTGAACCCCCGTTTTGATGAGAATGCTG TGGTCCGCAACACCCAGATCGACAACTCCTGGGGGTCTGAGGAGCGAAGTCTGCCCCGAAAAATGCCCTTCGTCCGTGGCCAGAGCTTCTCAGTAAGGCA CCGCAGTCTGGAGCTTGGAGAGGCTCCCATGGGTGCACAGGGGGAGGGGGTAAAGGAGGTTTGAGGTACCTTGAACAGTATGGGGGCTGATTCCTCTGGG ATGAAGGCCCAAAAGAAGAGAAGGTGGCCAACAAATTATTATTATTATTACTGTCCCGCATGAAGGAAGTGCTGGGATCTGCTTTTTCAGATGAGGAAAC AAACTCACAAGTGCAGGTTACTTGCTTGTGGTCACACAGTCAGTAAGTGTCAAATCAGACCCAAGAAGGAGGTGTTATTCATTTCTTCATTTACTCAACA ACCATTTTCTTGTCGCCTGCTTTGCGCAGGAAGCACCCCACATGCTGGGGGCACAGTCATGAAGCACACAGACAGGGTCCTGCCTCCAGGGAGTTTATAA TTTAGGTGGGGAAAGAACAAGGAAAGTAAAGCATGGACAGATTGTCACAGATAACGACAGTGCCACGCACAAAGCAAAACAGAGCGATGAGATAGAGCGA GCCTGGGAGGGGCAGCTAGGGCCAACGTGCAGAGGCACGGGTGTGGCCTGTCCAGGAACAGCAGGCAGGCGTGCTCCACCCTGACTACATATTCAAATCA CCCAGAGAGCTTACAAAGGAAATATCAGTGCTGGGACCCCAGCCCAGGCCAATGAGGCAGTCAGCTGGGCATTCGTATTTTAAAAATATGCCTTAAGTGA TTATACTCTGCAGTCAGAGTTGAAAATGACTGATGTAGGGCTTTGCAGCCATGGAAAGGAGCTTGGATTTTAACACAGTGAAAAGCCTCAGGAGTGTTTC AAGCCAGGGAGCAACATACTTTGATTTGTAGACAGCTGTGTGACCTCGGACAAGTGACTTAATTATTCTGTGCTTCAGTTTCCTCATCTACAAAATGGAG CTAATAATCATGAATTTCCTAGAGTTGTAAGAATGGAATGAGACAGTATCTGTAGTATGCTTAGGACAGTGCCTGGCAGGTGGCATGTGTGATAGGAGTG TTAGCTATTGCAAAGGGAAGGAGGTTTTAACATTTGTACCCTGACTGCTTCGTGGAGAAGGCATTGGGGTGGAAAAGACAAGTTAGGAGACTGATGCTGC AGGAGCCCAGGCCCAGAGCACTCCTGTGTGCTGGGCCTGAGGGATACAGACGGCACAGGCCAGTGCTCCTGTCCCTGATGGGGTGGGAACAGTATTCTAG ACCAGGGAACAGTACAGGGGAAAGAGCAC

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ VCCELSDWLQWK*HCLPLQPSV*RWRVRGVQHEA ERKLGARGEEDTHAFPEGDAL*PLLPGAELRFQ ASSNLPACGLPTRLPLPRQSSTQCRAPLDRCSL LPPSHL*CTPTPPIRCLSSPPFWEGCTHPSPSSC QALSCPVLRGSTSTCALGTTSPST*TPVLMRML WSATPRSTTPGGLRSEVCPEKCPSSVARASQ*G TAVWSLERLPWVHRGRG*RRFEVP*TVWGLIPLG *RPKRREGGQQIIIIITVPHEGSAGICFFR*GN KLTSAGYLLVVTQSVSVKSDPRRRCYSFLHLLN NHFLVACFAQEAPHMLGAQS*STQTGSCLQGVYN LGGERTRKVKHGQIVTDNDSATHKAKQSDEIER AWEGQLGPTCRGTGVACPGTAGRRAPP*LHIQI TQRAYKGNISAGTPAQANEAVSWAFVF*KYALSD YTLQSELKMTDVGLCSHGKELGF*HSEKPQECF KPGSNIL*FVDSCVTSDK*LNYSVLQFPHLQNG ANNHEFPRVVRME*DSICSMLRTVPGRWHV**EC *LLQREGGFNICTLTASWRRHWGGKDKLGD*CC RSPGPEHSCVLGLRDTDGTGQCSCP*WGGNSIL DQGTVQGKEH

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR FAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTR QNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFK PVQTSRRVACQPGSHYPDSHPHSAERPWTDVLY SRHPTYDVPPPRLSDAFHHHHSGRAVPIQVHPP VRHCPAQCSEVPHQPVLWEPHRLPPEPPF**ECC GPQHPDRQLLGV*GAKSAPKNALRPWPELLSKA PQSGAWRGSHGCTGGGGKGGLRYLEQYGG*FLW DEGPKEEKVANKLLLLLLSRMKEVLGSAFSDEET NSQVQVTCLWSHSQ*VSNQTQEGGVIHFFIYST TIFLSPALRRKHPTCWGHSHEAHRQGPASREFI I*VGKEQGK*SMDRLSQITTVPRTKQNRAMR*SE PGRGS*GQRAEARVWPVQEQQAGVLHPDYIFKS PRELTKEISVLGPQPRPMRQSAGHSYFKNMP*V IILCSQS*K*LM*GFAAMERSLDFNTVKSLRSVS SQGATYFDL*TAV*PRTSDLIILCFSFLIYKME LIIMNFLEL*EWNETVSVVCLGQCLAGGMCDRS VSYCKGKEVLTFVP*LLRGEGIGVEKTS*ETDAA GAQAQSTPVCWA*GIQTAQASAPVPDGVGTVF* TREQYRGKS

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPG LL*TFRLASVEMTLPSTSTLGLKMEGTWCATRG RTEAGGPRRGRHTCLSRRGCPLTSASWCRAQIS SQFKPPGVWPANPAPITQTVIHTVQSAPGQMFST PAIPPMMYPHPAYPMPFITTILGGLYPSKSILL SGTVLPSAQRFHINLCSGNHIAFHLNPRFDENA VVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVRH RSLELGEAPMGAQGEGVKEV*GTLNSMGADSSG MKAQKKRRWPTNYYYYYCPA*RKCWDLLFQMRK QTHKCRLLACGHTVSKCQIRPKKEVLFISSFTQQ PFSCRLLCAGSTPHAGGTVMKHTDRVLPPGSL* FRWGKNKESKAWTDCHR*RQCHAQSKTER*DRA SLGGAARANVQRHGCGLSRNSRQACSTLTTYSNH PESLQRKYQCWDPSPGQ*GSQLGIRILKICLK* LYSAVRVEND*CRALQPWKGAWILTQ*KASGVF QAREQHTLICRQLCDLGQVT*LFCASVSSSTKWS **S*IS*SCKNGMRQYL*YA*DSAWQVACVIGV LAIAKGRRF*HLYPDCFVEKALGWKRQVRRLML QEPRPRALLCAGPEGYRRHRPVLLSLMGWEQYSR PGNSTGERA

Sequence LGALS9.dAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGG TTTGCTGTGAACTTTCAGACTGGCTTCAGTGGAAATGACATTGCCTTCCACTTCAACCCTCGGTTTGAAGATGGAGGGTACGTGGTGTGCAACACGAGGC AGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTCTGCTTCCTGGTGCAGAGCTCAGATTTCAA GGTGATGGTGAACGGGATCCTCTTCGTGCAGTACTTCCACCGCGTGCCCTTCCACCGTGTGGACACCATCTCCGTCAATGGCTCTGTGCAGCTGTCCTAC ATCAGCTTCCAGCCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGTGCAGAGCGCCCCTGGACAGATGTTCTCTA CTCCCGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGAGGGCTGTACCCATCCAAGTCCATCCTCCT GTCAGGCACTGTCCTGCCCAGTGCTCAGAGGTGTGGATCTTGTGTGAAGCTCACTGCCTCAAGGTGGCCGTGGATGGTCAGCACCTGTTTGAATACTACC ATCGCCTGAGGAACCTGCCCACCATCAACAGACTGGAAGTGGGGGGCGACATCCAGCTGACCCATGTGCAGACATAGGCGGCTTCCTGGCCCTGGGGCCG GGGGCTGGGGTGTGGGGCAGTCTGGGTCCTCTCATCATCCCCACTTCCCAGGCCCAGCCTTTCCAACCCTGCCTGGGATCTGGGCTTTAATGCAGAGGCC ATGTCCTTGTCTGGTCCTGCTTCTGGCTACAGCCACCCTGGAACGGAGAAGGCAGCTGACGGGGATTGCCTTCCTCAGCCGCAGCAGCACCTGGGGCTCC AGCTGCTGGAATCCTACCATCCCAGGAGGCAGGCACAGCCAGGGAGAGGGGAGGAGTGGGCAGTGAAGATGAAGCCCCATGCTCAGTCCCCTCCCATCCC CCACGCAGCTCCACCCCAGTCCCAAGCCACCAGCTGTCTGCTCCTGGTGGGAGGTGGCCTCCTCAGCCCCTCCTCTCTGACCTTTAACCTCACTCTCACC TTGCACCGTGCACCAACCCTTCACCCCTCCTGGAAAGCAGGCCTGATGGCTTCCCACTGGCCTCCACCACCTGACCAGAGTGTTCTCTTCAGAGGACTGG CTCCTTTCCCAGTGTCCTTAAAATAAAGAAATGAAAATGCTTGTTGGCACATTCA

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ VCCELSDWLQWK*HCLPLQPSV*RWRVRGVQHEA ERKLGARGEEDTHAFPEGDAL*PLLPGAELRFQ GDGERDPLRAVLPPRALPPCGHHLRQWLCAAVL HQLPASRRVACQPGSHYPDSHPHSAERPWTDVLY SRHPTYDVPPPRLSDAFHHHHSGRAVPIQVHPP VRHCPAQCSEVWILCEAHCLKVAVDGQHLFEYY HRLRNLPTINRLEVGGDIQLTHVQT*AASWPWGR GLGCGAVWVLSSSPLPRPSLSNPAWDLGFNAEA MSLSGPASGYSHPGTEKAADGDCLPQPQQHLGL QLLESYHPRRQAQPGRGEEWAVKMKPHAQSPPIP HAAPPQSQATSCLLLVGGGLLSPSSLTFNLTLT LHRAPTLHPSWKAGLMASHWPPPPDQSVLFRGL APFPVSLK*RNENACWHI

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR FAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTR QNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFK VMVNGILFVQYFHRVPFHRVDTISVNGSVQLSY ISFQPPGVWPANPAPITQTVIHTVQSAPGQMFS TPAIPPMMYPHPAYPMPFITTILGGLYPSKSILL SGTVLPSAQRCGSCVKLTASRWPWMVSTCLNTT IA*GTCPPSTDWKWGATSS*PMCRHRRLPGPGA GGWGVGQSGSSHHPHFPGPAFPTLPGIWALMQRP CPCLVLLLATATLERRRQLTGIAFLSRSSTWGS SCWNPTIPGGRHSQGEGRSGQ*R*SPMLSPLPS PTQLHPSPKPPAVCSWWEVASSAPPL*PLTSLSP CTVHQPFTPPGKQA*WLPTGLHHLTRVFSSEDW LLSQCP*NKEMKMLVGTF

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPG LL*TFRLASVEMTLPSTSTLGLKMEGTWCATRG RTEAGGPRRGRHTCLSRRGCPLTSASWCRAQIS R*W*TGSSSCSTSTACPSTVWTPSPSMALCSCPT SASSLPACGLPTRLPLPRQSSTQCRAPLDRCSL LPPSHL*CTPTPPIRCLSSPPFWEGCTHPSPSS CQALSCPVLRGVDLV*SSLPQGGRGWSAPV*ILP SPEEPAHHQQTGSGGRHPADPCADIGGFLALGP GAGVWGSLGPLIIPTSQAQPFQPCLGSGL*CRG HVLVWSCFWLQPPWNGEGS*RGLPSSAAAAPGAP AAGILPSQEAGTARERGGVGSEDEAPCSVPSHP PRSSTPVPSHQLSAPGGRWPPQPLLSDL*PHSH LAPCTNPSPLLESRPDGFPLASTT*PECSLQRTG SFPSVLKIKK*KCLLAHS

Sequence LGALS9.cAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGA TGGAGGGTACGTGGTGTGCAACACGAGGCAGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTC TGCTTCCTGGTGCAGAGCTCAGATTTCAAGGTGATGGTGAACGGGATCCTCTTCGTGCAGTACTTCCACCGCGTGCCCTTCCACCGTGTGGACACCATCT CCGTCAATGGCTCTGTGCAGCTGTCCTACATCAGCTTCCAGCCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGT GCAGAGCGCCCCTGGACAGATGTTCTCTACTCCCGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGA GGGCTGTACCCATCCAAGTCCATCCTCCTGTCAGGCACTGTCCTGCCCAGTGCTCAGAGGTTCCACATCAACCTGTGCTCTGGGAACCACATCGCCTTCC ACCTGAACCCCCGTTTTGATGAGAATGCTGTGGTCCGCAACACCCAGATCGACAACTCCTGGGGGTCTGAGGAGCGAAGTCTGCCCCGAAAAATGCCCTT CGTCCGTGGCCAGAGCTTCTCAGTGTGGATCTTGTGTGAAGCTCACTGCCTCAAGGTGGCCGTGGATGGTCAGCACCTGTTTGAATACTACCATCGCCTG AGGAACCTGCCCACCATCAACAGACTGGAAGTGGGGGGCGACATCCAGCTGACCCATGTGCAGACATAGGCGGCTTCCTGGCCCTGGGGCCGGGGGCTGG GGTGTGGGGCAGTCTGGGTCCTCTCATCATCCCCACTTCCCAGGCCCAGCCTTTCCAACCCTGCCTGGGATCTGGGCTTTAATGCAGAGGCCATGTCCTT GTCTGGTCCTGCTTCTGGCTACAGCCACCCTGGAACGGAGAAGGCAGCTGACGGGGATTGCCTTCCTCAGCCGCAGCAGCACCTGGGGCTCCAGCTGCTG GAATCCTACCATCCCAGGAGGCAGGCACAGCCAGGGAGAGGGGAGGAGTGGGCAGTGAAGATGAAGCCCCATGCTCAGTCCCCTCCCATCCCCCACGCAG CTCCACCCCAGTCCCAAGCCACCAGCTGTCTGCTCCTGGTGGGAGGTGGCCTCCTCAGCCCCTCCTCTCTGACCTTTAACCTCACTCTCACCTTGCACCG TGCACCAACCCTTCACCCCTCCTGGAAAGCAGGCCTGATGGCTTCCCACTGGCCTCCACCACCTGACCAGAGTGTTCTCTTCAGAGGACTGGCTCCTTTC CCAGTGTCCTTAAAATAAAGAAATGAAAATGCTTGTTGGCACATTCA

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ MEGTWCATRGRTEAGGPRRGRHTCLSRRGCPLTS ASWCRAQISR*W*TGSSSCSTSTACPSTVWTPS PSMALCSCPTSASSLPACGLPTRLPLPRQSSTQ CRAPLDRCSLLPPSHL*CTPTPPIRCLSSPPFWE GCTHPSPSSCQALSCPVLRGSTSTCALGTTSPS T*TPVLMRMLWSATPRSTTPGGLRSEVCPEKCP SSVARASQCGSCVKLTASRWPWMVSTCLNTTIA* GTCPPSTDWKWGATSS*PMCRHRRLPGPGAGGW GVGQSGSSHHPHFPGPAFPTLPGIWALMQRPCP CLVLLLATATLERRRQLTGIAFLSRSSTWGSSCW NPTIPGGRHSQGEGRSGQ*R*SPMLSPLPSPTQ LHPSPKPPAVCSWWEVASSAPPL*PLTSLSPCT VHQPFTPPGKQA*WLPTGLHHLTRVFSSEDWLLS QCP*NKEMKMLVGTF

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR WRVRGVQHEAERKLGARGEEDTHAFPEGDAL*P LLPGAELRFQGDGERDPLRAVLPPRALPPCGHHL RQWLCAAVLHQLPASRRVACQPGSHYPDSHPHS AERPWTDVLYSRHPTYDVPPPRLSDAFHHHHSG RAVPIQVHPPVRHCPAQCSEVPHQPVLWEPHRLP PEPPF**ECCGPQHPDRQLLGV*GAKSAPKNAL RPWPELLSVDLV*SSLPQGGRGWSAPV*ILPSP EEPAHHQQTGSGGRHPADPCADIGGFLALGPGAG VWGSLGPLIIPTSQAQPFQPCLGSGL*CRGHVL VWSCFWLQPPWNGEGS*RGLPSSAAAAPGAPAA GILPSQEAGTARERGGVGSEDEAPCSVPSHPPRS STPVPSHQLSAPGGRWPPQPLLSDL*PHSHLAP CTNPSPLLESRPDGFPLASTT*PECSLQRTGSF PSVLKIKK*KCLLAHS

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPD GGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDL CFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTI SVNGSVQLSYISFQPPGVWPANPAPITQTVIHTV QSAPGQMFSTPAIPPMMYPHPAYPMPFITTILG GLYPSKSILLSGTVLPSAQRFHINLCSGNHIAF HLNPRFDENAVVRNTQIDNSWGSEERSLPRKMPF VRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRL RNLPTINRLEVGGDIQLTHVQT*AASWPWGRGL GCGAVWVLSSSPLPRPSLSNPAWDLGFNAEAMSL SGPASGYSHPGTEKAADGDCLPQPQQHLGLQLL ESYHPRRQAQPGRGEEWAVKMKPHAQSPPIPHA APPQSQATSCLLLVGGGLLSPSSLTFNLTLTLHR APTLHPSWKAGLMASHWPPPPDQSVLFRGLAPF PVSLK*RNENACWHI

Sequence LGALS9.bAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGG TTTGCTGTGAACTTTCAGACTGGCTTCAGTGGAAATGACATTGCCTTCCACTTCAACCCTCGGTTTGAAGATGGAGGGTACGTGGTGTGCAACACGAGGC AGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTCTGCTTCCTGGTGCAGAGCTCAGATTTCAA GGTGATGGTGAACGGGATCCTCTTCGTGCAGTACTTCCACCGCGTGCCCTTCCACCGTGTGGACACCATCTCCGTCAATGGCTCTGTGCAGCTGTCCTAC ATCAGCTTCCAGCCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGTGCAGAGCGCCCCTGGACAGATGTTCTCTA CTCCCGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGAGGGCTGTACCCATCCAAGTCCATCCTCCT GTCAGGCACTGTCCTGCCCAGTGCTCAGAGGTTCCACATCAACCTGTGCTCTGGGAACCACATCGCCTTCCACCTGAACCCCCGTTTTGATGAGAATGCT GTGGTCCGCAACACCCAGATCGACAACTCCTGGGGGTCTGAGGAGCGAAGTCTGCCCCGAAAAATGCCCTTCGTCCGTGGCCAGAGCTTCTCAGTGTGGA TCTTGTGTGAAGCTCACTGCCTCAAGGTGGCCGTGGATGGTCAGCACCTGTTTGAATACTACCATCGCCTGAGGAACCTGCCCACCATCAACAGACTGGA AGTGGGGGGCGACATCCAGCTGACCCATGTGCAGACATAGGCGGCTTCCTGGCCCTGGGGCCGGGGGCTGGGGTGTGGGGCAGTCTGGGTCCTCTCATCA TCCCCACTTCCCAGGCCCAGCCTTTCCAACCCTGCCTGGGATCTGGGCTTTAATGCAGAGGCCATGTCCTTGTCTGGTCCTGCTTCTGGCTACAGCCACC CTGGAACGGAGAAGGCAGCTGACGGGGATTGCCTTCCTCAGCCGCAGCAGCACCTGGGGCTCCAGCTGCTGGAATCCTACCATCCCAGGAGGCAGGCACA GCCAGGGAGAGGGGAGGAGTGGGCAGTGAAGATGAAGCCCCATGCTCAGTCCCCTCCCATCCCCCACGCAGCTCCACCCCAGTCCCAAGCCACCAGCTGT CTGCTCCTGGTGGGAGGTGGCCTCCTCAGCCCCTCCTCTCTGACCTTTAACCTCACTCTCACCTTGCACCGTGCACCAACCCTTCACCCCTCCTGGAAAG CAGGCCTGATGGCTTCCCACTGGCCTCCACCACCTGACCAGAGTGTTCTCTTCAGAGGACTGGCTCCTTTCCCAGTGTCCTTAAAATAAAGAAATGAAAA TGCTTGTTGGCACATTCA

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ VCCELSDWLQWK*HCLPLQPSV*RWRVRGVQHEA ERKLGARGEEDTHAFPEGDAL*PLLPGAELRFQ GDGERDPLRAVLPPRALPPCGHHLRQWLCAAVL HQLPASRRVACQPGSHYPDSHPHSAERPWTDVLY SRHPTYDVPPPRLSDAFHHHHSGRAVPIQVHPP VRHCPAQCSEVPHQPVLWEPHRLPPEPPF**EC CGPQHPDRQLLGV*GAKSAPKNALRPWPELLSVD LV*SSLPQGGRGWSAPV*ILPSPEEPAHHQQTG SGGRHPADPCADIGGFLALGPGAGVWGSLGPLI IPTSQAQPFQPCLGSGL*CRGHVLVWSCFWLQPP WNGEGS*RGLPSSAAAAPGAPAAGILPSQEAGT ARERGGVGSEDEAPCSVPSHPPRSSTPVPSHQL SAPGGRWPPQPLLSDL*PHSHLAPCTNPSPLLES RPDGFPLASTT*PECSLQRTGSFPSVLKIKK*K CLLAHS

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR FAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTR QNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFK VMVNGILFVQYFHRVPFHRVDTISVNGSVQLSY ISFQPPGVWPANPAPITQTVIHTVQSAPGQMFS TPAIPPMMYPHPAYPMPFITTILGGLYPSKSILL SGTVLPSAQRFHINLCSGNHIAFHLNPRFDENA VVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVW ILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRLE VGGDIQLTHVQT*AASWPWGRGLGCGAVWVLSS SPLPRPSLSNPAWDLGFNAEAMSLSGPASGYSH PGTEKAADGDCLPQPQQHLGLQLLESYHPRRQAQ PGRGEEWAVKMKPHAQSPPIPHAAPPQSQATSC LLLVGGGLLSPSSLTFNLTLTLHRAPTLHPSWK AGLMASHWPPPPDQSVLFRGLAPFPVSLK*RNEN ACWHI

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPG LL*TFRLASVEMTLPSTSTLGLKMEGTWCATRG RTEAGGPRRGRHTCLSRRGCPLTSASWCRAQIS R*W*TGSSSCSTSTACPSTVWTPSPSMALCSCPT SASSLPACGLPTRLPLPRQSSTQCRAPLDRCSL LPPSHL*CTPTPPIRCLSSPPFWEGCTHPSPSS CQALSCPVLRGSTSTCALGTTSPST*TPVLMRML WSATPRSTTPGGLRSEVCPEKCPSSVARASQCG SCVKLTASRWPWMVSTCLNTTIA*GTCPPSTDW KWGATSS*PMCRHRRLPGPGAGGWGVGQSGSSHH PHFPGPAFPTLPGIWALMQRPCPCLVLLLATAT LERRRQLTGIAFLSRSSTWGSSCWNPTIPGGRH SQGEGRSGQ*R*SPMLSPLPSPTQLHPSPKPPAV CSWWEVASSAPPL*PLTSLSPCTVHQPFTPPGK QA*WLPTGLHHLTRVFSSEDWLLSQCP*NKEMK MLVGTF