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Sequences

Sequence LGALS9.jAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGG TTTGCTGTGAACTTTCAGACTGGCTTCAGTGGAAATGACATTGCCTTCCACTTCAACCCTCGGTTTGAAGATGGAGGGTACGTGGTGTGCAACACGAGGC AGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTCTGCTTCCTGGTGCAGAGCTCAGATTTCAA GCCAGTTCAAACCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGTGCAGAGCGCCCCTGGACAGATGTTCTCTAC TCCCGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGAGGGCTGTACCCATCCAAGTCCATCCTCCTG TCAGGCACTGTCCTGCCCAGTGCTCAGAGGTTCCACATCAACCTGTGCTCTGGGAACCACATCGCCTTCCACCTGAACCCCCGTTTTGATGAGAATGCTG TGGTCCGCAACACCCAGATCGACAACTCCTGGGGGTCTGAGGAGCGAAGTCTGCCCCGAAAAATGCCCTTCGTCCGTGGCCAGAGCTTCTCAGTAAGGCA CCGCAGTCTGGAGCTTGGAGAGGCTCCCATGGGTGCACAGGGGGAGGGGGTAAAGGAGGTTTGAGGTACCTTGAACAGTATGGGGGCTGATTCCTCTGGG ATGAAGGCCCAAAAGAAGAGAAGGTGGCCAACAAATTATTATTATTATTACTGTCCCGCATGAAGGAAGTGCTGGGATCTGCTTTTTCAGATGAGGAAAC AAACTCACAAGTGCAGGTTACTTGCTTGTGGTCACACAGTCAGTAAGTGTCAAATCAGACCCAAGAAGGAGGTGTTATTCATTTCTTCATTTACTCAACA ACCATTTTCTTGTCGCCTGCTTTGCGCAGGAAGCACCCCACATGCTGGGGGCACAGTCATGAAGCACACAGACAGGGTCCTGCCTCCAGGGAGTTTATAA TTTAGGTGGGGAAAGAACAAGGAAAGTAAAGCATGGACAGATTGTCACAGATAACGACAGTGCCACGCACAAAGCAAAACAGAGCGATGAGATAGAGCGA GCCTGGGAGGGGCAGCTAGGGCCAACGTGCAGAGGCACGGGTGTGGCCTGTCCAGGAACAGCAGGCAGGCGTGCTCCACCCTGACTACATATTCAAATCA CCCAGAGAGCTTACAAAGGAAATATCAGTGCTGGGACCCCAGCCCAGGCCAATGAGGCAGTCAGCTGGGCATTCGTATTTTAAAAATATGCCTTAAGTGA TTATACTCTGCAGTCAGAGTTGAAAATGACTGATGTAGGGCTTTGCAGCCATGGAAAGGAGCTTGGATTTTAACACAGTGAAAAGCCTCAGGAGTGTTTC AAGCCAGGGAGCAACATACTTTGATTTGTAGACAGCTGTGTGACCTCGGACAAGTGACTTAATTATTCTGTGCTTCAGTTTCCTCATCTACAAAATGGAG CTAATAATCATGAATTTCCTAGAGTTGTAAGAATGGAATGAGACAGTATCTGTAGTATGCTTAGGACAGTGCCTGGCAGGTGGCATGTGTGATAGGAGTG TTAGCTATTGCAAAGGGAAGGAGGTTTTAACATTTGTACCCTGACTGCTTCGTGGAGAAGGCATTGGGGTGGAAAAGACAAGTTAGGAGACTGATGCTGC AGGAGCCCAGGCCCAGAGCACTCCTGTGTGCTGGGCCTGAGGGATACAGACGGCACAGGCCAGTGCTCCTGTCCCTGATGGGGTGGGAACAGTATTCTAG ACCAGGGAACAGTACAGGGGAAAGAGCAC

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ VCCELSDWLQWK*HCLPLQPSV*RWRVRGVQHEA ERKLGARGEEDTHAFPEGDAL*PLLPGAELRFQ ASSNLPACGLPTRLPLPRQSSTQCRAPLDRCSL LPPSHL*CTPTPPIRCLSSPPFWEGCTHPSPSSC QALSCPVLRGSTSTCALGTTSPST*TPVLMRML WSATPRSTTPGGLRSEVCPEKCPSSVARASQ*G TAVWSLERLPWVHRGRG*RRFEVP*TVWGLIPLG *RPKRREGGQQIIIIITVPHEGSAGICFFR*GN KLTSAGYLLVVTQSVSVKSDPRRRCYSFLHLLN NHFLVACFAQEAPHMLGAQS*STQTGSCLQGVYN LGGERTRKVKHGQIVTDNDSATHKAKQSDEIER AWEGQLGPTCRGTGVACPGTAGRRAPP*LHIQI TQRAYKGNISAGTPAQANEAVSWAFVF*KYALSD YTLQSELKMTDVGLCSHGKELGF*HSEKPQECF KPGSNIL*FVDSCVTSDK*LNYSVLQFPHLQNG ANNHEFPRVVRME*DSICSMLRTVPGRWHV**EC *LLQREGGFNICTLTASWRRHWGGKDKLGD*CC RSPGPEHSCVLGLRDTDGTGQCSCP*WGGNSIL DQGTVQGKEH

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR FAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTR QNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFK PVQTSRRVACQPGSHYPDSHPHSAERPWTDVLY SRHPTYDVPPPRLSDAFHHHHSGRAVPIQVHPP VRHCPAQCSEVPHQPVLWEPHRLPPEPPF**ECC GPQHPDRQLLGV*GAKSAPKNALRPWPELLSKA PQSGAWRGSHGCTGGGGKGGLRYLEQYGG*FLW DEGPKEEKVANKLLLLLLSRMKEVLGSAFSDEET NSQVQVTCLWSHSQ*VSNQTQEGGVIHFFIYST TIFLSPALRRKHPTCWGHSHEAHRQGPASREFI I*VGKEQGK*SMDRLSQITTVPRTKQNRAMR*SE PGRGS*GQRAEARVWPVQEQQAGVLHPDYIFKS PRELTKEISVLGPQPRPMRQSAGHSYFKNMP*V IILCSQS*K*LM*GFAAMERSLDFNTVKSLRSVS SQGATYFDL*TAV*PRTSDLIILCFSFLIYKME LIIMNFLEL*EWNETVSVVCLGQCLAGGMCDRS VSYCKGKEVLTFVP*LLRGEGIGVEKTS*ETDAA GAQAQSTPVCWA*GIQTAQASAPVPDGVGTVF* TREQYRGKS

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPG LL*TFRLASVEMTLPSTSTLGLKMEGTWCATRG RTEAGGPRRGRHTCLSRRGCPLTSASWCRAQIS SQFKPPGVWPANPAPITQTVIHTVQSAPGQMFST PAIPPMMYPHPAYPMPFITTILGGLYPSKSILL SGTVLPSAQRFHINLCSGNHIAFHLNPRFDENA VVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVRH RSLELGEAPMGAQGEGVKEV*GTLNSMGADSSG MKAQKKRRWPTNYYYYYCPA*RKCWDLLFQMRK QTHKCRLLACGHTVSKCQIRPKKEVLFISSFTQQ PFSCRLLCAGSTPHAGGTVMKHTDRVLPPGSL* FRWGKNKESKAWTDCHR*RQCHAQSKTER*DRA SLGGAARANVQRHGCGLSRNSRQACSTLTTYSNH PESLQRKYQCWDPSPGQ*GSQLGIRILKICLK* LYSAVRVEND*CRALQPWKGAWILTQ*KASGVF QAREQHTLICRQLCDLGQVT*LFCASVSSSTKWS **S*IS*SCKNGMRQYL*YA*DSAWQVACVIGV LAIAKGRRF*HLYPDCFVEKALGWKRQVRRLML QEPRPRALLCAGPEGYRRHRPVLLSLMGWEQYSR PGNSTGERA

Sequence LGALS9.iAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGA TGGAGGGTACGTGGTGTGCAACACGAGGCAGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTC TGCTTCCTGGTGCAGAGCTCAGATTTCAAGGTGATGGTGAACGGGATCCTCTTCGTGCAGTACTTCCACCGCGTGCCCTTCCACCGTGTGGACACCATCT CCGTCAATGGCTCTGTGCAGCTGTCCTACATCAGCTTCCAGAACCCCCGCACAGTCCCTGTTCAGCCTGCCTTCTCCACGGTGCCGTTCTCCCAGCCTGT CTGTTTCCCACCCAGGCCCAGGGGGCGCAGACAAAAACCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGTGCAG AGCGCCCCTGGACAGATGTTCTCTACTCCCGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGAGGGC TGTACCCATCCAAGTCCATCCTCCTGTCAGGCACTGTCCTGCCCAGTGCTCAGAGGTAAGCCAAGGGCTCCAGTGACCTCTGGGAAGAGAGAGCCCTTCA AGGTCAGTCCAGCCATTCCCCTGGCTTCAGGAAGGCTACTGATGATGGGGAGGAAATGGGACTCAGAATTCGGTGGATAAAGGTTCAGGTGGGCTGCCCA CCCCAGGTTCCACATCAACCTGTGCTCTGGGAACCACATCGCCTTCCACCTGAACCCCCGTTTTGATGAGAATGCTGTGGTCCGCAACACCCAGATCGAC AACTCCTGGGGGTCTGAGGAGCGAAGTCTGCCCCGAAAAATGCCCTTCGTCCGTGGCCAGAGCTTCTCAGTAAGGCACCGCAGTCTGGAGCTTGGAGAGG CTCCCATGGGTGCACAGGGGGAGGGGGTAAAGGAGGTTTGAGGTACCTTGAACAGTATGGGGGCTGATTCCTCTGGGATGAAGGCCCAAAAGAAGAGAAG GTGGCCAACAAATTATTATTATTATTACTGTCCCGCATGAAGGAAGTGCTGGGATCTGCTTTTTCAGATGAGGAAACAAACTCACAAGTGCAGGTTACTT GCTTGTGGTCACACAGTCAGTAAGTGTCAAATCAGACCCAAGAAGGAGGTGTTATTCATTTCTTCATTTACTCAACAACCATTTTCTTGTCGCCTGCTTT GCGCAGGAAGCACCCCACATGCTGGGGGCACAGTCATGAAGCACACAGACAGGGTCCTGCCTCCAGGGAGTTTATAATTTAGGTGGGGAAAGAACAAGGA AAGTAAAGCATGGACAGATTGTCACAGATAACGACAGTGCCACGCACAAAGCAAAACAGAGCGATGAGATAGAGCGAGCCTGGGAGGGGCAGCTAGGGCC AACGTGCAGAGGCACGGGTGTGGCCTGTCCAGGAACAGCAGGCAGGCGTGCTCCACCCTGACTACATATTCAAATCACCCAGAGAGCTTACAAAGGAAAT ATCAGTGCTGGGACCCCAGCCCAGGCCAATGAGGCAGTCAGCTGGGCATTCGTATTTTAAAAATATGCCTTAAGTGATTATACTCTGCAGTCAGAGTTGA AAATGACTGATGTAGGGCTTTGCAGCCATGGAAAGGAGCTTGGATTTTAACACAGTGAAAAGCCTCAGGAGTGTTTCAAGCCAGGGAGCAACATACTTTG ATTTGTAGACAGCTGTGTGACCTCGGACAAGTGACTTAATTATTCTGTGCTTCAGTTTCCTCATCTACAAAATGGAGCTAATAATCATGAATTTCCTAGA GTTGTAAGAATGGAATGAGACAGTATCTGTAGTATGCTTAGGACAGTGCCTGGCAGGTGGCATGTGTGATAGGAGTGTTAGCTATTGCAAAGGGAAGGAG GTTTTAACATTTGTACCCTGACTGCTTCGTGGAGAAGGCATTGGGGTGGAAAAGACAAGTTAGGAGACTGATGCTGCAGGAGCCCAGGCCCAGAGCACTC CTGTGTGCTGGGCCTGAGGGATACAGACGGCACAGGCCAGTGCTCCTGTCCCTGATGGGGTGGGAACAGTATTCTAGACCAGGGAACAGTACAGGGGAAA GAGCAC

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ MEGTWCATRGRTEAGGPRRGRHTCLSRRGCPLTS ASWCRAQISR*W*TGSSSCSTSTACPSTVWTPS PSMALCSCPTSASRTPAQSLFSLPSPRCRSPSL SVSHPGPGGADKNLPACGLPTRLPLPRQSSTQCR APLDRCSLLPPSHL*CTPTPPIRCLSSPPFWEG CTHPSPSSCQALSCPVLRGKPRAPVTSGKREPF KVSPAIPLASGRLLMMGRKWDSEFGG*RFRWAAH PRFHINLCSGNHIAFHLNPRFDENAVVRNTQID NSWGSEERSLPRKMPFVRGQSFSVRHRSLELGE APMGAQGEGVKEV*GTLNSMGADSSGMKAQKKRR WPTNYYYYYCPA*RKCWDLLFQMRKQTHKCRLL ACGHTVSKCQIRPKKEVLFISSFTQQPFSCRLL CAGSTPHAGGTVMKHTDRVLPPGSL*FRWGKNKE SKAWTDCHR*RQCHAQSKTER*DRASLGGAARA NVQRHGCGLSRNSRQACSTLTTYSNHPESLQRK YQCWDPSPGQ*GSQLGIRILKICLK*LYSAVRVE ND*CRALQPWKGAWILTQ*KASGVFQAREQHTL ICRQLCDLGQVT*LFCASVSSSTKWS**S*IS* SCKNGMRQYL*YA*DSAWQVACVIGVLAIAKGRR F*HLYPDCFVEKALGWKRQVRRLMLQEPRPRAL LCAGPEGYRRHRPVLLSLMGWEQYSRPGNSTGE RA

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR WRVRGVQHEAERKLGARGEEDTHAFPEGDAL*P LLPGAELRFQGDGERDPLRAVLPPRALPPCGHHL RQWLCAAVLHQLPEPPHSPCSACLLHGAVLPAC LFPTQAQGAQTKTSRRVACQPGSHYPDSHPHSA ERPWTDVLYSRHPTYDVPPPRLSDAFHHHHSGRA VPIQVHPPVRHCPAQCSEVSQGLQ*PLGRESPS RSVQPFPWLQEGY**WGGNGTQNSVDKGSGGLP TPGSTSTCALGTTSPST*TPVLMRMLWSATPRST TPGGLRSEVCPEKCPSSVARASQ*GTAVWSLER LPWVHRGRG*RRFEVP*TVWGLIPLG*RPKRRE GGQQIIIIITVPHEGSAGICFFR*GNKLTSAGYL LVVTQSVSVKSDPRRRCYSFLHLLNNHFLVACF AQEAPHMLGAQS*STQTGSCLQGVYNLGGERTR KVKHGQIVTDNDSATHKAKQSDEIERAWEGQLGP TCRGTGVACPGTAGRRAPP*LHIQITQRAYKGN ISAGTPAQANEAVSWAFVF*KYALSDYTLQSEL KMTDVGLCSHGKELGF*HSEKPQECFKPGSNIL* FVDSCVTSDK*LNYSVLQFPHLQNGANNHEFPR VVRME*DSICSMLRTVPGRWHV**EC*LLQREG GFNICTLTASWRRHWGGKDKLGD*CCRSPGPEHS CVLGLRDTDGTGQCSCP*WGGNSILDQGTVQGK EH

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPD GGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDL CFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTI SVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPV CFPPRPRGRRQKPPGVWPANPAPITQTVIHTVQ SAPGQMFSTPAIPPMMYPHPAYPMPFITTILGG LYPSKSILLSGTVLPSAQR*AKGSSDLWEERALQ GQSSHSPGFRKATDDGEEMGLRIRWIKVQVGCP PQVPHQPVLWEPHRLPPEPPF**ECCGPQHPDR QLLGV*GAKSAPKNALRPWPELLSKAPQSGAWRG SHGCTGGGGKGGLRYLEQYGG*FLWDEGPKEEK VANKLLLLLLSRMKEVLGSAFSDEETNSQVQVT CLWSHSQ*VSNQTQEGGVIHFFIYSTTIFLSPAL RRKHPTCWGHSHEAHRQGPASREFII*VGKEQG K*SMDRLSQITTVPRTKQNRAMR*SEPGRGS*G QRAEARVWPVQEQQAGVLHPDYIFKSPRELTKEI SVLGPQPRPMRQSAGHSYFKNMP*VIILCSQS* K*LM*GFAAMERSLDFNTVKSLRSVSSQGATYF DL*TAV*PRTSDLIILCFSFLIYKMELIIMNFLE L*EWNETVSVVCLGQCLAGGMCDRSVSYCKGKE VLTFVP*LLRGEGIGVEKTS*ETDAAGAQAQST PVCWA*GIQTAQASAPVPDGVGTVF*TREQYRGK S

Sequence LGALS9.aAug05

TGTTTGTTAAATTATATGTAGGGACAGGGTCTTCCAACCTTTCCCGAGCTGGTCTCAAGCTCCTGGGCTGAAGTGATCCTCCTGCCTCAGCCTCTCAAAG TGCTGGTATTATAGGCATAAGCCACCACGCCCTGCCCATTTTTCTAAGTTGGATTATTTTACACTCCAGTCTGCTGTGAATGAGAGTTCCAGTTGTTGCG TATCGCAATCAATTTGTGATTGCCTACAAATGATGTGCCGTGATGAAATTGTCCCTGGTGTCCGAGAGGATCGCAAAGAATTTCCCTTCCTTTCTCTCCT TTCTGCTCCCCTTGTACTGTCTACTCCTTAAACTGGTACTTGATCCAGGAACATAATGGGGATGGACAGTGCAGATGGCACACATGGCCTCAGTCTATTG GAGCATCTCAAAGGAATTAGTCTGCAAATTCTAGTGCATCTAGGTGGAGCACAGGAAGGAAGAGAGGTGCAGACTCACGTATGGCCCTGGGGCACCTGCC ATCCTCTCGCACCCGTACAGCCCTTACCTGCCAGCACTTACCCTACCCAGCTTGAGTTCTGGGCCTTCTCACCAGCACATCGCTGGGACCTGGTCGACTT CAGGTAAGTTTATTTCATGGCTCCCTCCCCCACGACCTGCACATGCCATATGTTCCTTCCCAGCCCCATGTCACTTGAAATGTTCTATCATGTCCAAGAC TTCTCTCCTCATCCTAAAGTGCAGAAAATAAGGATGGAGAAGAGAAGGAGAAGAGAATCAAGAGAGATTCATTGAGAGGGAGGATCAGAAGCTCCTGGGC ACCCCATACTGTAGAATAAAAATATTCATTATGGTGTTTTTCTTGCAAAATATTCCCCTCTACATAATTATGTTTTTACATGAATAATATAAATTTAAAC AGGAGAAATACTTTTTGAAGAGTCTGAGAATCTTCATAAAGTTCAGGCGGCCACGAATTAGCTGTGTGACCTGGGGCATGCCCCTTAGACTCTGAGCCTC AGCTTCTCTGTATGTAAAATGGGTTGAAGCCGCCCTTCCCCACAAGCACCCTGTGCACAGGCAATGCCCAGCCCCATTATTTTCTGGACTCCGTGGCCAA GCATGCTTAGGACACACAGCCACATACTTCTGGGCAGTGTCATCTGGCAACTTGCTGTCATGTCAGTGTGGTCAAGCATTGTAGACCTCTATGAACCAAA TATGCTTCAGGCTTGGGTTGAGCACAGGAGAGGGAGGAGGGAAAGGTCACTGGGGCTGGGAGTGCCTACTTCCCTCTGTGAGTGTCACCCCAGTCCACCC AGTACCATACCTTTCTCTCTCTGGACCCACTTCCTTTTGCTGCCGGCTCCTCCCCATTGAATAACAGCCAAGTTGCTTTGGTTTCTATTTCTTTGTTAAG TCGTTCCCTCTACAAAGGACTTCCTAGTGGGTGTGAAAGGCAGCGGTGGCCACAGAGGCGGCGGAGAGATGGCCTTCAGCGGTTCCCAGGCTCCCTACCT GAGTCCAGCTGTCCCCTTTTCTGGGACTATTCAAGGAGGTCTCCAGGACGGACTTCAGATCACTGTCAATGGGACCGTTCTCAGCTCCAGTGGAACCAGG TTTGCTGTGAACTTTCAGACTGGCTTCAGTGGAAATGACATTGCCTTCCACTTCAACCCTCGGTTTGAAGATGGAGGGTACGTGGTGTGCAACACGAGGC AGAACGGAAGCTGGGGGCCCGAGGAGAGGAAGACACACATGCCTTTCCAGAAGGGGATGCCCTTTGACCTCTGCTTCCTGGTGCAGAGCTCAGATTTCAA GGTGATGGTGAACGGGATCCTCTTCGTGCAGTACTTCCACCGCGTGCCCTTCCACCGTGTGGACACCATCTCCGTCAATGGCTCTGTGCAGCTGTCCTAC ATCAGCTTCCAGAACCCCCGCACAGTCCCTGTTCAGCCTGCCTTCTCCACGGTGCCGTTCTCCCAGCCTGTCTGTTTCCCACCCAGGCCCAGGGGGCGCA GACAAAAACCTCCCGGCGTGTGGCCTGCCAACCCGGCTCCCATTACCCAGACAGTCATCCACACAGTGCAGAGCGCCCCTGGACAGATGTTCTCTACTCC CGCCATCCCACCTATGATGTACCCCCACCCCGCCTATCCGATGCCTTTCATCACCACCATTCTGGGAGGGCTGTACCCATCCAAGTCCATCCTCCTGTCA GGCACTGTCCTGCCCAGTGCTCAGAGGTTCCACATCAACCTGTGCTCTGGGAACCACATCGCCTTCCACCTGAACCCCCGTTTTGATGAGAATGCTGTGG TCCGCAACACCCAGATCGACAACTCCTGGGGGTCTGAGGAGCGAAGTCTGCCCCGAAAAATGCCCTTCGTCCGTGGCCAGAGCTTCTCAGTGTGGATCTT GTGTGAAGCTCACTGCCTCAAGGTGGCCGTGGATGGTCAGCACCTGTTTGAATACTACCATCGCCTGAGGAACCTGCCCACCATCAACAGACTGGAAGTG GGGGGCGACATCCAGCTGACCCATGTGCAGACATAGGCGGCTTCCTGGCCCTGGGGCCGGGGGCTGGGGTGTGGGGCAGTCTGGGTCCTCTCATCATCCC CACTTCCCAGGCCCAGCCTTTCCAACCCTGCCTGGGATCTGGGCTTTAATGCAGAGGCCATGTCCTTGTCTGGTCCTGCTTCTGGCTACAGCCACCCTGG AACGGAGAAGGCAGCTGACGGGGATTGCCTTCCTCAGCCGCAGCAGCACCTGGGGCTCCAGCTGCTGGAATCCTACCATCCCAGGAGGCAGGCACAGCCA GGGAGAGGGGAGGAGTGGGCAGTGAAGATGAAGCCCCATGCTCAGTCCCCTCCCATCCCCCACGCAGCTCCACCCCAGTCCCAAGCCACCAGCTGTCTGC TCCTGGTGGGAGGTGGCCTCCTCAGCCCCTCCTCTCTGACCTTTAACCTCACTCTCACCTTGCACCGTGCACCAACCCTTCACCCCTCCTGGAAAGCAGG CCTGATGGCTTCCCACTGGCCTCCACCACCTGACCAGAGTGTTCTCTTCAGAGGACTGGCTCCTTTCCCAGTGTCCTTAAAATAAAGAAATGAAAATGCT TGTTGGCACATTCA

LGALS9.F5 (forward primer)
LGALS9.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

CLLNYM*GQGLPTFPELVSSSWAEVILLPQPLK VLVL*A*ATTPCPFF*VGLFYTPVCCE*EFQLLR IAINL*LPTNDVP**NCPWCPRGSQRISLPFSP FCSPCTVYSLNWYLIQEHNGDGQCRWHTWPQSI GASQRN*SANSSASRWSTGRKRGADSRMALGHLP SSRTRTALTCQHLPYPA*VLGLLTSTSLGPGRL QVSLFHGSLPHDLHMPYVPSQPHVT*NVLSCPR LLSSS*SAENKDGEEKEKRIKRDSLRGRIRSSWA PHTVE*KYSLWCFSCKIFPST*LCFYMNNINLN RRNTF*RV*ESS*SSGGHELAV*PGACPLDSEP QLLCM*NGLKPPFPTSTLCTGNAQPHYFLDSVAK HA*DTQPHTSGQCHLATCCHVSVVKHCRPL*TK YASGLG*AQEREEGKVTGAGSAYFPL*VSPQST QYHTFLSLDPLPFAAGSSPLNNSQVALVSISLLS RSLYKGLPSGCERQRWPQRRRRDGLQRFPGSLP ESSCPLFWDYSRRSPGRTSDHCQWDRSQLQWNQ VCCELSDWLQWK*HCLPLQPSV*RWRVRGVQHEA ERKLGARGEEDTHAFPEGDAL*PLLPGAELRFQ GDGERDPLRAVLPPRALPPCGHHLRQWLCAAVL HQLPEPPHSPCSACLLHGAVLPACLFPTQAQGAQ TKTSRRVACQPGSHYPDSHPHSAERPWTDVLYS RHPTYDVPPPRLSDAFHHHHSGRAVPIQVHPPV RHCPAQCSEVPHQPVLWEPHRLPPEPPF**ECCG PQHPDRQLLGV*GAKSAPKNALRPWPELLSVDL V*SSLPQGGRGWSAPV*ILPSPEEPAHHQQTGS GGRHPADPCADIGGFLALGPGAGVWGSLGPLIIP TSQAQPFQPCLGSGL*CRGHVLVWSCFWLQPPW NGEGS*RGLPSSAAAAPGAPAAGILPSQEAGTA RERGGVGSEDEAPCSVPSHPPRSSTPVPSHQLSA PGGRWPPQPLLSDL*PHSHLAPCTNPSPLLESR PDGFPLASTT*PECSLQRTGSFPSVLKIKK*KC LLAHS

Frame 1

VC*IICRDRVFQPFPSWSQAPGLK*SSCLSLSK CWYYRHKPPRPAHFSKLDYFTLQSAVNESSSCC VSQSICDCLQMMCRDEIVPGVREDRKEFPFLSLL SAPLVLSTP*TGT*SRNIMGMDSADGTHGLSLL EHLKGISLQILVHLGGAQEGREVQTHVWPWGTC HPLAPVQPLPASTYPTQLEFWAFSPAHRWDLVDF R*VYFMAPSPTTCTCHMFLPSPMSLEMFYHVQD FSPHPKVQKIRMEKRRRRESREIH*EGGSEAPG HPIL*NKNIHYGVFLAKYSPLHNYVFT*II*I*T GEILFEESENLHKVQAATN*LCDLGHAP*TLSL SFSVCKMG*SRPSPQAPCAQAMPSPIIFWTPWP SMLRTHSHILLGSVIWQLAVMSVWSSIVDLYEPN MLQAWVEHRRGRRERSLGLGVPTSLCECHPSPP STIPFSLWTHFLLLPAPPH*ITAKLLWFLFLC* VVPSTKDFLVGVKGSGGHRGGGEMAFSGSQAPYL SPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR FAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTR QNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFK VMVNGILFVQYFHRVPFHRVDTISVNGSVQLSY ISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGR RQKPPGVWPANPAPITQTVIHTVQSAPGQMFSTP AIPPMMYPHPAYPMPFITTILGGLYPSKSILLS GTVLPSAQRFHINLCSGNHIAFHLNPRFDENAV VRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWIL CEAHCLKVAVDGQHLFEYYHRLRNLPTINRLEV GGDIQLTHVQT*AASWPWGRGLGCGAVWVLSSS PLPRPSLSNPAWDLGFNAEAMSLSGPASGYSHPG TEKAADGDCLPQPQQHLGLQLLESYHPRRQAQP GRGEEWAVKMKPHAQSPPIPHAAPPQSQATSCL LLVGGGLLSPSSLTFNLTLTLHRAPTLHPSWKAG LMASHWPPPPDQSVLFRGLAPFPVSLK*RNENA CWHI

Frame 2

FVKLYVGTGSSNLSRAGLKLLG*SDPPASASQS AGIIGISHHALPIFLSWIILHSSLL*MRVPVVA YRNQFVIAYK*CAVMKLSLVSERIAKNFPSFLS FLLPLYCLLLKLVLDPGT*WGWTVQMAHMASVYW SISKELVCKF*CI*VEHRKEERCRLTYGPGAPA ILSHPYSPYLPALTLPSLSSGPSHQHIAGTWST SGKFISWLPPPRPAHAICSFPAPCHLKCSIMSKT SLLILKCRK*GWRREGEENQERFIEREDQKLLG TPYCRIKIFIMVFFLQNIPLYIIMFLHE*YKFK QEKYFLKSLRIFIKFRRPRISCVTWGMPLRL*AS ASLYVKWVEAALPHKHPVHRQCPAPLFSGLRGQ ACLGHTATYFWAVSSGNLLSCQCGQAL*TSMNQ ICFRLGLSTGEGGGKGHWGWECLLPSVSVTPVHP VPYLSLSGPTSFCCRLLPIE*QPSCFGFYFFVK SFPLQRTS*WV*KAAVATEAAERWPSAVPRLPT *VQLSPFLGLFKEVSRTDFRSLSMGPFSAPVEPG LL*TFRLASVEMTLPSTSTLGLKMEGTWCATRG RTEAGGPRRGRHTCLSRRGCPLTSASWCRAQIS R*W*TGSSSCSTSTACPSTVWTPSPSMALCSCPT SASRTPAQSLFSLPSPRCRSPSLSVSHPGPGGA DKNLPACGLPTRLPLPRQSSTQCRAPLDRCSLL PPSHL*CTPTPPIRCLSSPPFWEGCTHPSPSSCQ ALSCPVLRGSTSTCALGTTSPST*TPVLMRMLW SATPRSTTPGGLRSEVCPEKCPSSVARASQCGS CVKLTASRWPWMVSTCLNTTIA*GTCPPSTDWKW GATSS*PMCRHRRLPGPGAGGWGVGQSGSSHHP HFPGPAFPTLPGIWALMQRPCPCLVLLLATATL ERRRQLTGIAFLSRSSTWGSSCWNPTIPGGRHSQ GEGRSGQ*R*SPMLSPLPSPTQLHPSPKPPAVC SWWEVASSAPPL*PLTSLSPCTVHQPFTPPGKQ A*WLPTGLHHLTRVFSSEDWLLSQCP*NKEMKML VGTF