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Sequences

Sequence BCAS1.bAug05

GTATTCAGCCAGCAGGCTCTGCACAAGGAAGCAAAGTGCAGGGAGCCAGGCTCCACCGACAGCCAGGCACTGGGCAGCACGCACTGGAGACCCAGGACCC TGTGCAGGAGCAGCTCCGGGTGACACGAGGGGACTGAAGATACTCCCACAGGGGCTCAGCAGGAGCAATGGGTAACCAAATGAGTGTTCCCCAAAGAGTT GAAGACCAAGAGAATGAACCAGAAGCAGAGACTTACCAGGACAACGCGTCTGCTCTGAACGGGGTTCCAGTGGTGGTGTCGACCCACACAGTTCAGCACT TAGAGGAAGTCGACTTGGGAATAAGTGTCAAGACGGATAATGTGGCCACTTCTTCCCCCGAGACAACGGAGATAAGTGCTGTTGCGGATGCCAACGGAAA GAATCTTGGGAAAGAGGCCAAACCCGAGGCACCAGCTGCTAAATCTCGTTTTTTCTTGATGCTCTCTCGGCCTGTACCAGGACGTACCGGAGACCAAGCC GCAGATTCATCCCTTGGATCAGTGAAGCTTGATGTCAGCTCCAATAAAGCTCCAGCGAACAAAGACCCAAGTGAGAGCTGGACACTTCCGGTGGCAGCTG GACCGGGGCAGGACACAGATAAAACCCCAGGGCACGCCCCGGCCCAAGACAAGGTCCTCTCTGCCGCCAGGGATCCCACGCTTCTCCCACCTGAGACAGG GGGAGCAGGAGGAGAAGCTCCCTCCAAGCCCAAGGACTCCAGCTTTTTTGACAAATTCTTCAAGCTGGACAAGGGACAGGAAAAGGTGCCAGGTGACAGC CAACAGGAAGCCAAGAGGGCAGAGCATCAAGACAAGGTGGATGAGGTTCCTGGCTTATCAGGGCAGTCCGATGATGTCCCTGCAGGGAAGGACATAGTTG ACGGCAAGGAAAAAGAAGGACAAGAACTTGGAACTGCGGATTGCTCTGTCCCTGGGGACCCAGAAGGACTGGAGACTGCAAAGGACGATTCCCAGGCAGC AGCTATAGCAGAGAATAATAATTCCATCATGAGTTTCTTTAAAACTCTGGTTTCACCTAACAAAGCTGAAACAAAAAAGGACCCAGAAGACACGGGTGCT GAAAAGTCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGCAACC CATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTGGGCAAACTGTTTTG GAAAAAGTCAGTTAAAGAGGACTCAGTCCCCACAGGTGCGGAGGAGAATACATCAGACTCCACAGAAAAGACTATCACACCGCCAGAGCCTGAACCAACA GGAGCACCACAGAAGGGTAAAGAGGGCTCCTCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAGCAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAG CCCAGTGCACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGAATGGGGACAAGCTCCAAAAGAGACCTGAGAAGCGGCAGCAGTCCCTTGGGGGCTT CTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAAACAGACCCAGTATCCATCGGACCAGTTGGCAAATCCAAGTAAACAAATCAGCAC GGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTTCTCCTTACTCCATCTCCTCCCCAAACACGCTCCATGTATATATTCTTCTGATGGCCAGCAAATG AAATTCTGCCTAGAAATTAAGCCCGAGCTGTTGTATATTGAGGTGTATTATTTACGTCTCTGGTCCAGTCTTTTCTGGCAAATAACAGTAAAGATGGTTT AGCAGGTCACCTAGTTGGGTCAGAAGAGTCGATGATCACCAAGCAGGAAAGGGAGGGAATAGAGGAATGTGTTCGGGTTAAGTGATGAAAATGGCAGTGG TGGCCGGGCGTGGTGGCTCTCGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACA TCATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAGCTACTCGGGAGCCCAACGCACGAGAACCGC TTGTACCCAGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGCACCATTGCACTCCACCCTGGGCGACAGAGCAAGATTCTATCAAAAAAAAAAAAAGGCAGT GGCAAGTAAGTTATAGAAGAGAAATGCTGCTAGAAGGAATTAAGCGTTGTAGTAAATGCGTGCTTATCCTCTAAGCTTGAAGAAGGGAGACGAAAATCCA TTTGTTTAAATTCACATCTCAAGGAGGGAGAACCCGGGCTGTGTTGGGTGGTTGCCAATTTCCTAGAACGGAATGTGTGGGGTATAGAAAAAGGAATGAA TAAGCGTTGTTTTTCAAATAGGGTCCTTGTAAGTTATTGATGAGAGGGAAAAGATTGACTGGGGAGGGCTTAAAATGATTTGGGAAAACAATTGCTTTTG AGGCTCAGTGACAACGGCAAAGATTACAACTTAAAAAAAAAAAATAAATAAAAAATAAAGGAAGTTGCACGGTTATTTTGCAACACAAGGGGGCGGCAAG GTCCCCATTTTTATCCTGTAATACTGTATCCCTAACAAAGATTTGGTCTCTGCTATCTTACATTATTAATGTTTCTCAGATGGCTGAGGGGCTCGCTTCA TCTGTTCCGTCTGACACTTATCTCAAGTGTGTCTGTCATTCCTAATGTTCTCAGGATGTGCTCTGATAAAACCCTCCCCATAACCTCAGTTAATAAAAAT TTACAGAAGACTTCTCAAATACCTGAGTTGTTTTTAATACCTGTACAAAGGAGTAAATAGGACCCTGAGTCTATTAAAATGTAATTCAAAGTAGCATATG ATTGACTGACAGTCATGTAAACTGTATCTTTCTTTTTCTGATTTAATAAAAAATACATTTACTTCTAAAGTATCTTTTAATTTTCAACTTCAAAGCAGTC CCACTCTATATCTGAGATGACTCTAACTTCTACATTATAAAATCCATACTCTTTCTCCATTATCTTCTTTGGAAGATCATTCTCTCCCAGATCTTCCCGG ATTTCCTTGTATATGGGCACACACACACACAAATGTGTGCAGTTGTATGTTTGCATGTACACACACATGCATGTATAGAATAGTGCTGTCTTAGGCCAGG TTGCTTGGAGCAGAGCCTGAGATGGGGATTTGGACGCATAGGATATACTGAGAGTGGGCTCCGAGGGAAAGGGAGTAAGAGAAAAAGAAGAGGGCAAGAA AAGAGTTGGGCAAGGGTTGGTTTCAACTGGAGCATGAATTGCACCACCCAGATAGTTTGACCTTGAGTCAAGGGAGCCAGCCTTTGAACCCTGGTAGGTG AATTCTGGGCTGCCCTGGGAGGTGGGGGG

BCAS1.F1 (forward primer)
BCAS1.R1 (reverse primer)
Multiple exon skipping

Frame 0

VFSQQALHKEAKCREPGSTDSQALGSTHWRPRT LCRSSSG*HEGTEDTPTGAQQEQWVTK*VFPKEL KTKRMNQKQRLTRTTRLL*TGFQWWCRPTQFST *RKSTWE*VSRRIMWPLLPPRQRR*VLLRMPTE RILGKRPNPRHQLLNLVFS*CSLGLYQDVPETKP QIHPLDQ*SLMSAPIKLQRTKTQVRAGHFRWQL DRGRTQIKPQGTPRPKTRSSLPPGIPRFSHLRQ GEQEEKLPPSPRTPAFLTNSSSWTRDRKRCQVTA NRKPRGQSIKTRWMRFLAYQGSPMMSLQGRT*L TARKKKDKNLELRIALSLGTQKDWRLQRTIPRQ QL*QRIIIPS*VSLKLWFHLTKLKQKRTQKTRVL KSHPPLQLTLSQTKPTLHPRRPKGLARIPKDAT HRGTHSP*QPLNLRRKAPRRNQDPPLCLWANCF GKSQLKRTQSPQVRRRIHQTPQKRLSHRQSLNQQ EHHRRVKRAPRRTRSQQPR*TSRRATSRKPKNQ PSAQSRPRWTRTHCRMGTSSKRDLRSGSSPLGA SLKAWDQSGCWMLKCKQTQYPSDQLANPSKQIST VPTRFSCHQDVFSLLHLLPKHAPCIYSSDGQQM KFCLEIKPELLYIEVYYLRLWSSLFWQITVKMV *QVT*LGQKSR*SPSRKGRE*RNVFGLSDENGSG GRAWWLSPVISALWEAEAGGSPEVRSSRLAWPT S*NPVSTKNTKISQAWWHTPVVPATREPNAREP LVPRRWRLQ*AEVAPLHSTLGDRARFYQKKKKAV ASKL*KRNAARRN*AL**MRAYPLSLKKGDENP FV*IHISRRENPGCVGWLPIS*NGMCGV*KKE* ISVVFQIGSL*VIDEREKIDWGGLKMIWENNCF* GSVTTAKITT*KKKINKK*RKLHGYFATQGGGK VPIFIL*YCIPNKDLVSAILHY*CFSDG*GARF ICSV*HLSQVCLSFLMFSGCALIKPSP*PQLIKI YRRLLKYLSCF*YLYKGVNRTLSLLKCNSK*HM ID*QSCKLYLSFSDLIKNTFTSKVSFNFQLQSS PTLYLR*L*LLHYKIHTLSPLSSLEDHSLPDLPG FPCIWAHTHTNVCSCMFACTHTCMYRIVLS*AR LLGAEPEMGIWTHRIY*EWAPRERE*EKKKRAR KELGKGWFQLEHELHHPDSLTLSQGSQPLNPGR* ILGCPGRWG

Frame 1

YSASRLCTRKQSAGSQAPPTARHWAARTGDPGP CAGAAPGDTRGLKILPQGLSRSNG*PNECSPKS *RPRE*TRSRDLPGQRVCSERGSSGGVDPHSSAL RGSRLGNKCQDG*CGHFFPRDNGDKCCCGCQRK ESWERGQTRGTSC*ISFFLDALSACTRTYRRPS RRFIPWISEA*CQLQ*SSSEQRPK*ELDTSGGSW TGAGHR*NPRARPGPRQGPLCRQGSHASPT*DR GSRRRSSLQAQGLQLF*QILQAGQGTGKGAR*Q PTGSQEGRASRQGG*GSWLIRAVR*CPCREGHS* RQGKRRTRTWNCGLLCPWGPRRTGDCKGRFPGS SYSRE**FHHEFL*NSGFT*QS*NKKGPRRHGC *KVTHHFS*P*VRQSQLYIPGDPRGWQEFQRMQP IGAHTVRDNP*TCEGRHQGEIRTHLSASGQTVL EKVS*RGLSPHRCGGEYIRLHRKDYHTARA*TN RSTTEG*RGLLEGQEVSSRDEQAEEQQAGSQRTS PVHRAGHGGHELTAEWGQAPKET*EAAAVPWGL L*RPGTKADVGCSSANRPSIHRTSWQIQVNKSA RFPPGSPATKMCSPYSISSPNTLHVYILLMASK* NSA*KLSPSCCILRCIIYVSGPVFSGK*Q*RWF SRSPSWVRRVDDHQAGKGGNRGMCSG*VMKMAV VAGRGGSRL*SQHFGRPRQVDHLRSGVQD*PGQH HETPSLLKIQKLARHGGTHL*SQLLGSPTHENR LYPGGGGCSEPKLHHCTPPWATEQDSIKKKKRQ WQVSYRREMLLEGIKRCSKCVLIL*A*RRETKIH LFKFTSQGGRTRAVLGGCQFPRTECVGYRKRNE *ALFFK*GPCKLLMRGKRLTGEGLK*FGKTIAF EAQ*QRQRLQLKKKK*IKNKGSCTVILQHKGAAR SPFLSCNTVSLTKIWSLLSYIINVSQMAEGLAS SVPSDTYLKCVCHS*CSQDVL**NPPHNLS**K FTEDFSNT*VVFNTCTKE*IGP*VY*NVIQSSI* LTDSHVNCIFLFLI**KIHLLLKYLLIFNFKAV PLYI*DDSNFYIIKSILFLHYLLWKIILSQIFP DFLVYGHTHTQMCAVVCLHVHTHACIE*CCLRPG CLEQSLRWGFGRIGYTESGLRGKGSKRKRRGQE KSWARVGFNWSMNCTTQIV*P*VKGASL*TLVG EFWAALGGGG

Frame 2

IQPAGSAQGSKVQGARLHRQPGTGQHALETQDP VQEQLRVTRGD*RYSHRGSAGAMGNQMSVPQRV EDQENEPEAETYQDNASALNGVPVVVSTHTVQH LEEVDLGISVKTDNVATSSPETTEISAVADANGK NLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQA ADSSLGSVKLDVSSNKAPANKDPSESWTLPVAA GPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETG GAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDS QQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIV DGKEKEGQELGTADCSVPGDPEGLETAKDDSQAA AIAENNNSIMSFFKTLVSPNKAETKKDPEDTGA EKSPTTSADLKSDKANFTSQETQGAGKNSKGCN PSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFW KKSVKEDSVPTGAEENTSDSTEKTITPPEPEPT GAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEP AQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGF FKGLGPKRMLDAQVQTDPVSIGPVGKSK*TNQH GSHQVLLPPRCVLLTPSPPQTRSMYIFF*WPAN EILPRN*ARAVVY*GVLFTSLVQSFLANNSKDGL AGHLVGSEESMITKQEREGIEECVRVK**KWQW WPGVVALACNLSTLGGRGRWIT*GQEFKTSLAN IMKPRLY*KYKN*PGMVAHTCSPSYSGAQRTRTA CTQEVEVAVSRSCTIALHPGRQSKILSKKKKGS GK*VIEEKCC*KELSVVVNACLSSKLEEGRRKS ICLNSHLKEGEPGLCWVVANFLERNVWGIEKGMN KRCFSNRVLVSY**EGKD*LGRA*NDLGKQLLL RLSDNGKDYNLKKKNK*KIKEVARLFCNTRGRQ GPHFYPVILYP*QRFGLCYLTLLMFLRWLRGSLH LFRLTLISSVSVIPNVLRMCSDKTLPITSVNKN LQKTSQIPELFLIPVQRSK*DPESIKM*FKVAY D*LTVM*TVSFFF*FNKKYIYF*SIF*FSTSKQS HSISEMTLTSTL*NPYSFSIIFFGRSFSPRSSR ISLYMGTHTHKCVQLYVCMYTHMHV*NSAVLGQ VAWSRA*DGDLDA*DILRVGSEGKGVREKEEGKK RVGQGLVSTGA*IAPPR*FDLESREPAFEPW*V NSGLPWEVG

Sequence BCAS1.aAug05

GTATTCAGCCAGCAGGCTCTGCACAAGGAAGCAAAGTGCAGGGAGCCAGGCTCCACCGACAGCCAGGCACTGGGCAGCACGCACTGGAGACCCAGGACCC TGTGCAGGAGCAGCTCCGGGTGACACGAGGGGACTGAAGATACTCCCACAGGGGCTCAGCAGGAGCAATGGGTAACCAAATGAGTGTTCCCCAAAGAGTT GAAGACCAAGAGAATGAACCAGAAGCAGAGACTTACCAGGACAACGCGTCTGCTCTGAACGGGGTTCCAGTGGTGGTGTCGACCCACACAGTTCAGCACT TAGAGGAAGTCGACTTGGGAATAAGTGTCAAGACGGATAATGTGGCCACTTCTTCCCCCGAGACAACGGAGATAAGTGCTGTTGCGGATGCCAACGGAAA GAATCTTGGGAAAGAGGCCAAACCCGAGGCACCAGCTGCTAAATCTCGTTTTTTCTTGATGCTCTCTCGGCCTGTACCAGGACGTACCGGAGACCAAGCC GCAGATTCATCCCTTGGATCAGTGAAGCTTGATGTCAGCTCCAATAAAGCTCCAGCGAACAAAGACCCAAGTGAGAGCTGGACACTTCCGGTGGCAGCTG GACCGGGGCAGGACACAGATAAAACCCCAGGGCACGCCCCGGCCCAAGACAAGGTCCTCTCTGCCGCCAGGGATCCCACGCTTCTCCCACCTGAGACAGG GGGAGCAGGAGGAGAAGCTCCCTCCAAGCCCAAGGACTCCAGCTTTTTTGACAAATTCTTCAAGCTGGACAAGGGACAGGAAAAGGTGCCAGGTGACAGC CAACAGGAAGCCAAGAGGGCAGAGCATCAAGACAAGGTGGATGAGGTTCCTGGCTTATCAGGGCAGTCCGATGATGTCCCTGCAGGGAAGGACATAGTTG ACGGCAAGGAAAAAGAAGGACAAGAACTTGGAACTGCGGATTGCTCTGTCCCTGGGGACCCAGAAGGACTGGAGACTGCAAAGGACGATTCCCAGGCAGC AGCTATAGCAGAGAATAATAATTCCATCATGAGTTTCTTTAAAACTCTGGTTTCACCTAACAAAGCTGAAACAAAAAAGGACCCAGAAGACACGGGTGCT GAAAAGTCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGCAACC CATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTGGGCAAACTGTTTTG GAAAAAGTCAGTTAAAGAGGACTCAGTCCCCACAGGTGCGGAGGAGAATGTGGTGTGTGAGTCACCAGTAGAGATTATAAAGTCCAAGGAAGTAGAATCA GCCTTACAAACAGTGGACCTCAACGAAGGAGATGCTGCACCTGAACCCACAGAAGCGAAACTCAAAAGAGAAGAAAGCAAACCAAGAACCTCTCTGATGG CGTTTCTCAGACAAATGTCAGTGAAAGGGGATGGAGGGATCACCCACTCAGAAGAAATAAATGGGAAAGACTCCAGCTGCCAAACATCAGACTCCACAGA AAAGACTATCACACCGCCAGAGCCTGAACCAACAGGAGCACCACAGAAGGGTAAAGAGGGCTCCTCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAG CAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCCCAGTGCACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGAATGGGGACAAGCTCCAAAAGA GACCTGAGAAGCGGCAGCAGTCCCTTGGGGGCTTCTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAAACAGACCCAGTATCCATCGG ACCAGTTGGCAAATCCAAGTAAACAAATCAGCACGGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTTCTCCTTACTCCATCTCCTCCCCAAACACGC TCCATGTATATATTCTTCTGATGGCCAGCAAATGAAATTCTGCCTAGAAATTAAGCCCGAGCTGTTGTATATTGAGGTGTATTATTTACGTCTCTGGTCC AGTCTTTTCTGGCAAATAACAGTAAAGATGGTTTAGCAGGTCACCTAGTTGGGTCAGAAGAGTCGATGATCACCAAGCAGGAAAGGGAGGGAATAGAGGA ATGTGTTCGGGTTAAGTGATGAAAATGGCAGTGGTGGCCGGGCGTGGTGGCTCTCGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACC TGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACATCATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTAGTC CCAGCTACTCGGGAGCCCAACGCACGAGAACCGCTTGTACCCAGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGCACCATTGCACTCCACCCTGGGCGACA GAGCAAGATTCTATCAAAAAAAAAAAAAGGCAGTGGCAAGTAAGTTATAGAAGAGAAATGCTGCTAGAAGGAATTAAGCGTTGTAGTAAATGCGTGCTTA TCCTCTAAGCTTGAAGAAGGGAGACGAAAATCCATTTGTTTAAATTCACATCTCAAGGAGGGAGAACCCGGGCTGTGTTGGGTGGTTGCCAATTTCCTAG AACGGAATGTGTGGGGTATAGAAAAAGGAATGAATAAGCGTTGTTTTTCAAATAGGGTCCTTGTAAGTTATTGATGAGAGGGAAAAGATTGACTGGGGAG GGCTTAAAATGATTTGGGAAAACAATTGCTTTTGAGGCTCAGTGACAACGGCAAAGATTACAACTTAAAAAAAAAAAATAAATAAAAAATAAAGGAAGTT GCACGGTTATTTTGCAACACAAGGGGGCGGCAAGGTCCCCATTTTTATCCTGTAATACTGTATCCCTAACAAAGATTTGGTCTCTGCTATCTTACATTAT TAATGTTTCTCAGATGGCTGAGGGGCTCGCTTCATCTGTTCCGTCTGACACTTATCTCAAGTGTGTCTGTCATTCCTAATGTTCTCAGGATGTGCTCTGA TAAAACCCTCCCCATAACCTCAGTTAATAAAAATTTACAGAAGACTTCTCAAATACCTGAGTTGTTTTTAATACCTGTACAAAGGAGTAAATAGGACCCT GAGTCTATTAAAATGTAATTCAAAGTAGCATATGATTGACTGACAGTCATGTAAACTGTATCTTTCTTTTTCTGATTTAATAAAAAATACATTTACTTCT AAAGTATCTTTTAATTTTCAACTTCAAAGCAGTCCCACTCTATATCTGAGATGACTCTAACTTCTACATTATAAAATCCATACTCTTTCTCCATTATCTT CTTTGGAAGATCATTCTCTCCCAGATCTTCCCGGATTTCCTTGTATATGGGCACACACACACACAAATGTGTGCAGTTGTATGTTTGCATGTACACACAC ATGCATGTATAGAATAGTGCTGTCTTAGGCCAGGTTGCTTGGAGCAGAGCCTGAGATGGGGATTTGGACGCATAGGATATACTGAGAGTGGGCTCCGAGG GAAAGGGAGTAAGAGAAAAAGAAGAGGGCAAGAAAAGAGTTGGGCAAGGGTTGGTTTCAACTGGAGCATGAATTGCACCACCCAGATAGTTTGACCTTGA GTCAAGGGAGCCAGCCTTTGAACCCTGGTAGGTGAATTCTGGGCTGCCCTGGGAGGTGGGGGG

BCAS1.F1 (forward primer)
BCAS1.R1 (reverse primer)
Multiple exon skipping

Frame 0

VFSQQALHKEAKCREPGSTDSQALGSTHWRPRT LCRSSSG*HEGTEDTPTGAQQEQWVTK*VFPKEL KTKRMNQKQRLTRTTRLL*TGFQWWCRPTQFST *RKSTWE*VSRRIMWPLLPPRQRR*VLLRMPTE RILGKRPNPRHQLLNLVFS*CSLGLYQDVPETKP QIHPLDQ*SLMSAPIKLQRTKTQVRAGHFRWQL DRGRTQIKPQGTPRPKTRSSLPPGIPRFSHLRQ GEQEEKLPPSPRTPAFLTNSSSWTRDRKRCQVTA NRKPRGQSIKTRWMRFLAYQGSPMMSLQGRT*L TARKKKDKNLELRIALSLGTQKDWRLQRTIPRQ QL*QRIIIPS*VSLKLWFHLTKLKQKRTQKTRVL KSHPPLQLTLSQTKPTLHPRRPKGLARIPKDAT HRGTHSP*QPLNLRRKAPRRNQDPPLCLWANCF GKSQLKRTQSPQVRRRMWCVSHQ*RL*SPRK*NQ PYKQWTSTKEMLHLNPQKRNSKEKKANQEPL*W RFSDKCQ*KGMEGSPTQKK*MGKTPAAKHQTPQ KRLSHRQSLNQQEHHRRVKRAPRRTRSQQPR*TS RRATSRKPKNQPSAQSRPRWTRTHCRMGTSSKR DLRSGSSPLGASLKAWDQSGCWMLKCKQTQYPS DQLANPSKQISTVPTRFSCHQDVFSLLHLLPKHA PCIYSSDGQQMKFCLEIKPELLYIEVYYLRLWS SLFWQITVKMV*QVT*LGQKSR*SPSRKGRE*R NVFGLSDENGSGGRAWWLSPVISALWEAEAGGSP EVRSSRLAWPTS*NPVSTKNTKISQAWWHTPVV PATREPNAREPLVPRRWRLQ*AEVAPLHSTLGD RARFYQKKKKAVASKL*KRNAARRN*AL**MRAY PLSLKKGDENPFV*IHISRRENPGCVGWLPIS* NGMCGV*KKE*ISVVFQIGSL*VIDEREKIDWG GLKMIWENNCF*GSVTTAKITT*KKKINKK*RKL HGYFATQGGGKVPIFIL*YCIPNKDLVSAILHY *CFSDG*GARFICSV*HLSQVCLSFLMFSGCAL IKPSP*PQLIKIYRRLLKYLSCF*YLYKGVNRTL SLLKCNSK*HMID*QSCKLYLSFSDLIKNTFTS KVSFNFQLQSSPTLYLR*L*LLHYKIHTLSPLS SLEDHSLPDLPGFPCIWAHTHTNVCSCMFACTHT CMYRIVLS*ARLLGAEPEMGIWTHRIY*EWAPR ERE*EKKKRARKELGKGWFQLEHELHHPDSLTL SQGSQPLNPGR*ILGCPGRWG

Frame 1

YSASRLCTRKQSAGSQAPPTARHWAARTGDPGP CAGAAPGDTRGLKILPQGLSRSNG*PNECSPKS *RPRE*TRSRDLPGQRVCSERGSSGGVDPHSSAL RGSRLGNKCQDG*CGHFFPRDNGDKCCCGCQRK ESWERGQTRGTSC*ISFFLDALSACTRTYRRPS RRFIPWISEA*CQLQ*SSSEQRPK*ELDTSGGSW TGAGHR*NPRARPGPRQGPLCRQGSHASPT*DR GSRRRSSLQAQGLQLF*QILQAGQGTGKGAR*Q PTGSQEGRASRQGG*GSWLIRAVR*CPCREGHS* RQGKRRTRTWNCGLLCPWGPRRTGDCKGRFPGS SYSRE**FHHEFL*NSGFT*QS*NKKGPRRHGC *KVTHHFS*P*VRQSQLYIPGDPRGWQEFQRMQP IGAHTVRDNP*TCEGRHQGEIRTHLSASGQTVL EKVS*RGLSPHRCGGECGV*VTSRDYKVQGSRI SLTNSGPQRRRCCT*THRSETQKRRKQTKNLSDG VSQTNVSERGWRDHPLRRNKWERLQLPNIRLHR KDYHTARA*TNRSTTEG*RGLLEGQEVSSRDEQ AEEQQAGSQRTSPVHRAGHGGHELTAEWGQAPKE T*EAAAVPWGLL*RPGTKADVGCSSANRPSIHR TSWQIQVNKSARFPPGSPATKMCSPYSISSPNT LHVYILLMASK*NSA*KLSPSCCILRCIIYVSGP VFSGK*Q*RWFSRSPSWVRRVDDHQAGKGGNRG MCSG*VMKMAVVAGRGGSRL*SQHFGRPRQVDH LRSGVQD*PGQHHETPSLLKIQKLARHGGTHL*S QLLGSPTHENRLYPGGGGCSEPKLHHCTPPWAT EQDSIKKKKRQWQVSYRREMLLEGIKRCSKCVL IL*A*RRETKIHLFKFTSQGGRTRAVLGGCQFPR TECVGYRKRNE*ALFFK*GPCKLLMRGKRLTGE GLK*FGKTIAFEAQ*QRQRLQLKKKK*IKNKGS CTVILQHKGAARSPFLSCNTVSLTKIWSLLSYII NVSQMAEGLASSVPSDTYLKCVCHS*CSQDVL* *NPPHNLS**KFTEDFSNT*VVFNTCTKE*IGP *VY*NVIQSSI*LTDSHVNCIFLFLI**KIHLLL KYLLIFNFKAVPLYI*DDSNFYIIKSILFLHYL LWKIILSQIFPDFLVYGHTHTQMCAVVCLHVHT HACIE*CCLRPGCLEQSLRWGFGRIGYTESGLRG KGSKRKRRGQEKSWARVGFNWSMNCTTQIV*P* VKGASL*TLVGEFWAALGGGG

Frame 2

IQPAGSAQGSKVQGARLHRQPGTGQHALETQDP VQEQLRVTRGD*RYSHRGSAGAMGNQMSVPQRV EDQENEPEAETYQDNASALNGVPVVVSTHTVQH LEEVDLGISVKTDNVATSSPETTEISAVADANGK NLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQA ADSSLGSVKLDVSSNKAPANKDPSESWTLPVAA GPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETG GAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDS QQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIV DGKEKEGQELGTADCSVPGDPEGLETAKDDSQAA AIAENNNSIMSFFKTLVSPNKAETKKDPEDTGA EKSPTTSADLKSDKANFTSQETQGAGKNSKGCN PSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFW KKSVKEDSVPTGAEENVVCESPVEIIKSKEVES ALQTVDLNEGDAAPEPTEAKLKREESKPRTSLM AFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTE KTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNK QKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQK RPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIG PVGKSK*TNQHGSHQVLLPPRCVLLTPSPPQTR SMYIFF*WPANEILPRN*ARAVVY*GVLFTSLV QSFLANNSKDGLAGHLVGSEESMITKQEREGIEE CVRVK**KWQWWPGVVALACNLSTLGGRGRWIT *GQEFKTSLANIMKPRLY*KYKN*PGMVAHTCS PSYSGAQRTRTACTQEVEVAVSRSCTIALHPGRQ SKILSKKKKGSGK*VIEEKCC*KELSVVVNACL SSKLEEGRRKSICLNSHLKEGEPGLCWVVANFL ERNVWGIEKGMNKRCFSNRVLVSY**EGKD*LGR A*NDLGKQLLLRLSDNGKDYNLKKKNK*KIKEV ARLFCNTRGRQGPHFYPVILYP*QRFGLCYLTL LMFLRWLRGSLHLFRLTLISSVSVIPNVLRMCSD KTLPITSVNKNLQKTSQIPELFLIPVQRSK*DP ESIKM*FKVAYD*LTVM*TVSFFF*FNKKYIYF *SIF*FSTSKQSHSISEMTLTSTL*NPYSFSIIF FGRSFSPRSSRISLYMGTHTHKCVQLYVCMYTH MHV*NSAVLGQVAWSRA*DGDLDA*DILRVGSE GKGVREKEEGKKRVGQGLVSTGA*IAPPR*FDLE SREPAFEPW*VNSGLPWEVG