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Sequences

Sequence BCAS1.eAug05

AGAATAATAATTCCATCATGAGTTTCTTTAAAACTCTGGTTTCACCTAACAAAGCTGAAACAAAAAAGGACCCAGAAGACACGGGTGCTGAAAAGTCACC
CACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGCAACCCATCGGGGCAC
ACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTGGGCAAACTGTTTTGGAAAAAGTCAG
TTAAAGAGGACTCAGTCCCCACAGGTGCGGAGGAGAATTCAGTGAAAGGGGATGGAGGGATCACCCACTCAGAAGAAATAAATGGGAAAGACTCCAGCTG
CCAAACATCAGACTCCACAGAAAAGACTATCACACCGCCAGAGCCTGAACCAACAGGAGCACCACAGAAGGGTAAAGAGGGCTCCTCGAAGGACAAGAAG
TCAGCAGCCGAGATGAACAAGCAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCCCAGTGCACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGA
ATGGGGACAAGCTCCAAAAGAGACCTGAGAAGCGGCAGCAGTCCCTTGGGGGCTTCTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCA
AACAGACCCAGTATCCATCGGACCAGTTGGCAAATCCAAGTAAACAAATCAGCACGGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTTCTCCTTACT
CCATCTCCTCCCCAAACACGCTCCATGTATATATTCTTCTGATGGCCAGCAAATGAAATTCTGCCTAGAAATTAAGCCCGAGCTGTTGTATATTGAGGTG
TATTATTTACGTCTCTGGTCCAGTCTTTTCTGGCAAATAACAGTAAAGATGGTTTAGCAGGTCACCTAGTTGGGTCAGAAGAGTCGATGATCACCAAGCA
GGAAAGGGAGGGAATAGAGGAATGTGTTCGGGTTAAGTGATGAAAATGGCAGTGGTGGCCGGGCGTGGTGGCTCTCGCCTGTAATCTCAGCACTTTGGGA
GGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACATCATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCA
TGGTGGCACACACCTGTAGTCCCAGCTACTCGGGAGCCCAACGCACGAGAACCGCTTGTACCCAGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGCACCAT
TGCACTCCACCCTGGGCGACAGAGCAAGATTCTATCAAAAAAAAAAAAAGGCAGTGGCAAGTAAGTTATAGAAGAGAAATGCTGCTAGAAGGAATTAAGC
GTTGTAGTAAATGCGTGCTTATCCTCTAAGCTTGAAGAAGGGAGACGAAAATCCATTTGTTTAAATTCACATCTCAAGGAGGGAGAACCCGGGCTGTGTT
GGGTGGTTGCCAATTTCCTAGAACGGAATGTGTGGGGTATAGAAAAAGGAATGAATAAGCGTTGTTTTTCAAATAGGGTCCTTGTAAGTTATTGATGAGA
GGGAAAAGATTGACTGGGGAGGGCTTAAAATGATTTGGGAAAACAATTGCTTTTGAGGCTCAGTGACAACGGCAAAGATTACAACTTAAAAAAAAAAAAT
AAATAAAAAATAAAGGAAGTTGCACGGTTATTTTGCAACACAAGGGGGCGGCAAGGTCCCCATTTTTATCCTGTAATACTGTATCCCTAACAAAGATTTG
GTCTCTGCTATCTTACATTATTAATGTTTCTCAGATGGCTGAGGGGCTCGCTTCATCTGTTCCGTCTGACACTTATCTCAAGTGTGTCTGTCATTCCTAA
TGTTCTCAGGATGTGCTCTGATAAAACCCTCCCCATAACCTCAGTTAATAAAAATTTACAGAAGACTTCTCAAATACCTGAGTTGTTTTTAATACCTGTA
CAAAGGAGTAAATAGGACCCTGAGTCTATTAAAATGTAATTCAAAGTAGCATATGATTGACTGACAGTCATGTAAACTGTATCTTTCTTTTTCTGATTTA
ATAAAAAATACATTTACTTCTAAAGTATCTTTTAATTTTCAACTTCAAAGCAGTCCCACTCTATATCTGAGATGACTCTAACTTCTACATTATAAAATCC
ATACTCTTTCTCCATTATCTTCTTTGGAAGATCATTCTCTCCCAGATCTTCCCGGATTTCCTTGTATATGGGCACACACACACACAAATGTGTGCAGTTG
TATGTTTGCATGTACACACACATGCATGTATAGAATAGTGCTGTCTTAGGCCAGGTTGCTTGGAGCAGAGCCTGAGATGGGGATTTGGACGCATAGGATA
TACTGAGAGTGGGCTCCGAGGGAAAGGGAGTAAGAGAAAAAGAAGAGGGCAAGAAAAGAGTTGGGCAAGGGTTGGTTTCAACTGGAGCATGAATTGCACC
ACCCAGATAGTTTGACCTTGAGTCAAGGGAGCCAGCCTTTGAACCCTGGTAGGTGAATTCTGGGCTGCCCTGGGAGGTGGGGGG
  • BCAS1.F2 (forward primer)
  • BCAS1.R1 (reverse primer)
  • Single exon skipping

Frame 0

RIIIPS*VSLKLWFHLTKLKQKRTQKTRVLKSH
PPLQLTLSQTKPTLHPRRPKGLARIPKDATHRGT
HSP*QPLNLRRKAPRRNQDPPLCLWANCFGKSQ
LKRTQSPQVRRRIQ*KGMEGSPTQKK*MGKTPA
AKHQTPQKRLSHRQSLNQQEHHRRVKRAPRRTRS
QQPR*TSRRATSRKPKNQPSAQSRPRWTRTHCR
MGTSSKRDLRSGSSPLGASLKAWDQSGCWMLKC
KQTQYPSDQLANPSKQISTVPTRFSCHQDVFSLL
HLLPKHAPCIYSSDGQQMKFCLEIKPELLYIEV
YYLRLWSSLFWQITVKMV*QVT*LGQKSR*SPS
RKGRE*RNVFGLSDENGSGGRAWWLSPVISALWE
AEAGGSPEVRSSRLAWPTS*NPVSTKNTKISQA
WWHTPVVPATREPNAREPLVPRRWRLQ*AEVAP
LHSTLGDRARFYQKKKKAVASKL*KRNAARRN*A
L**MRAYPLSLKKGDENPFV*IHISRRENPGCV
GWLPIS*NGMCGV*KKE*ISVVFQIGSL*VIDE
REKIDWGGLKMIWENNCF*GSVTTAKITT*KKKI
NKK*RKLHGYFATQGGGKVPIFIL*YCIPNKDL
VSAILHY*CFSDG*GARFICSV*HLSQVCLSFL
MFSGCALIKPSP*PQLIKIYRRLLKYLSCF*YLY
KGVNRTLSLLKCNSK*HMID*QSCKLYLSFSDL
IKNTFTSKVSFNFQLQSSPTLYLR*L*LLHYKI
HTLSPLSSLEDHSLPDLPGFPCIWAHTHTNVCSC
MFACTHTCMYRIVLS*ARLLGAEPEMGIWTHRI
Y*EWAPRERE*EKKKRARKELGKGWFQLEHELH
HPDSLTLSQGSQPLNPGR*ILGCPGRWG

Frame 1

E**FHHEFL*NSGFT*QS*NKKGPRRHGC*KVT
HHFS*P*VRQSQLYIPGDPRGWQEFQRMQPIGA
HTVRDNP*TCEGRHQGEIRTHLSASGQTVLEKVS
*RGLSPHRCGGEFSERGWRDHPLRRNKWERLQL
PNIRLHRKDYHTARA*TNRSTTEG*RGLLEGQE
VSSRDEQAEEQQAGSQRTSPVHRAGHGGHELTAE
WGQAPKET*EAAAVPWGLL*RPGTKADVGCSSA
NRPSIHRTSWQIQVNKSARFPPGSPATKMCSPY
SISSPNTLHVYILLMASK*NSA*KLSPSCCILRC
IIYVSGPVFSGK*Q*RWFSRSPSWVRRVDDHQA
GKGGNRGMCSG*VMKMAVVAGRGGSRL*SQHFG
RPRQVDHLRSGVQD*PGQHHETPSLLKIQKLARH
GGTHL*SQLLGSPTHENRLYPGGGGCSEPKLHH
CTPPWATEQDSIKKKKRQWQVSYRREMLLEGIK
RCSKCVLIL*A*RRETKIHLFKFTSQGGRTRAVL
GGCQFPRTECVGYRKRNE*ALFFK*GPCKLLMR
GKRLTGEGLK*FGKTIAFEAQ*QRQRLQLKKKK
*IKNKGSCTVILQHKGAARSPFLSCNTVSLTKIW
SLLSYIINVSQMAEGLASSVPSDTYLKCVCHS*
CSQDVL**NPPHNLS**KFTEDFSNT*VVFNTC
TKE*IGP*VY*NVIQSSI*LTDSHVNCIFLFLI*
*KIHLLLKYLLIFNFKAVPLYI*DDSNFYIIKS
ILFLHYLLWKIILSQIFPDFLVYGHTHTQMCAV
VCLHVHTHACIE*CCLRPGCLEQSLRWGFGRIGY
TESGLRGKGSKRKRRGQEKSWARVGFNWSMNCT
TQIV*P*VKGASL*TLVGEFWAALGGGG

Frame 2

NNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSP
TTSADLKSDKANFTSQETQGAGKNSKGCNPSGH
TQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKS
VKEDSVPTGAEENSVKGDGGITHSEEINGKDSSC
QTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKK
SAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQ
NGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQ
TDPVSIGPVGKSK*TNQHGSHQVLLPPRCVLLT
PSPPQTRSMYIFF*WPANEILPRN*ARAVVY*G
VLFTSLVQSFLANNSKDGLAGHLVGSEESMITKQ
EREGIEECVRVK**KWQWWPGVVALACNLSTLG
GRGRWIT*GQEFKTSLANIMKPRLY*KYKN*PG
MVAHTCSPSYSGAQRTRTACTQEVEVAVSRSCTI
ALHPGRQSKILSKKKKGSGK*VIEEKCC*KELS
VVVNACLSSKLEEGRRKSICLNSHLKEGEPGLC
WVVANFLERNVWGIEKGMNKRCFSNRVLVSY**E
GKD*LGRA*NDLGKQLLLRLSDNGKDYNLKKKN
K*KIKEVARLFCNTRGRQGPHFYPVILYP*QRF
GLCYLTLLMFLRWLRGSLHLFRLTLISSVSVIPN
VLRMCSDKTLPITSVNKNLQKTSQIPELFLIPV
QRSK*DPESIKM*FKVAYD*LTVM*TVSFFF*F
NKKYIYF*SIF*FSTSKQSHSISEMTLTSTL*NP
YSFSIIFFGRSFSPRSSRISLYMGTHTHKCVQL
YVCMYTHMHV*NSAVLGQVAWSRA*DGDLDA*D
ILRVGSEGKGVREKEEGKKRVGQGLVSTGA*IAP
PR*FDLESREPAFEPW*VNSGLPWEVG

Sequence BCAS1.aAug05

GTATTCAGCCAGCAGGCTCTGCACAAGGAAGCAAAGTGCAGGGAGCCAGGCTCCACCGACAGCCAGGCACTGGGCAGCACGCACTGGAGACCCAGGACCC
TGTGCAGGAGCAGCTCCGGGTGACACGAGGGGACTGAAGATACTCCCACAGGGGCTCAGCAGGAGCAATGGGTAACCAAATGAGTGTTCCCCAAAGAGTT
GAAGACCAAGAGAATGAACCAGAAGCAGAGACTTACCAGGACAACGCGTCTGCTCTGAACGGGGTTCCAGTGGTGGTGTCGACCCACACAGTTCAGCACT
TAGAGGAAGTCGACTTGGGAATAAGTGTCAAGACGGATAATGTGGCCACTTCTTCCCCCGAGACAACGGAGATAAGTGCTGTTGCGGATGCCAACGGAAA
GAATCTTGGGAAAGAGGCCAAACCCGAGGCACCAGCTGCTAAATCTCGTTTTTTCTTGATGCTCTCTCGGCCTGTACCAGGACGTACCGGAGACCAAGCC
GCAGATTCATCCCTTGGATCAGTGAAGCTTGATGTCAGCTCCAATAAAGCTCCAGCGAACAAAGACCCAAGTGAGAGCTGGACACTTCCGGTGGCAGCTG
GACCGGGGCAGGACACAGATAAAACCCCAGGGCACGCCCCGGCCCAAGACAAGGTCCTCTCTGCCGCCAGGGATCCCACGCTTCTCCCACCTGAGACAGG
GGGAGCAGGAGGAGAAGCTCCCTCCAAGCCCAAGGACTCCAGCTTTTTTGACAAATTCTTCAAGCTGGACAAGGGACAGGAAAAGGTGCCAGGTGACAGC
CAACAGGAAGCCAAGAGGGCAGAGCATCAAGACAAGGTGGATGAGGTTCCTGGCTTATCAGGGCAGTCCGATGATGTCCCTGCAGGGAAGGACATAGTTG
ACGGCAAGGAAAAAGAAGGACAAGAACTTGGAACTGCGGATTGCTCTGTCCCTGGGGACCCAGAAGGACTGGAGACTGCAAAGGACGATTCCCAGGCAGC
AGCTATAGCAGAGAATAATAATTCCATCATGAGTTTCTTTAAAACTCTGGTTTCACCTAACAAAGCTGAAACAAAAAAGGACCCAGAAGACACGGGTGCT
GAAAAGTCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGCAACC
CATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTGGGCAAACTGTTTTG
GAAAAAGTCAGTTAAAGAGGACTCAGTCCCCACAGGTGCGGAGGAGAATGTGGTGTGTGAGTCACCAGTAGAGATTATAAAGTCCAAGGAAGTAGAATCA
GCCTTACAAACAGTGGACCTCAACGAAGGAGATGCTGCACCTGAACCCACAGAAGCGAAACTCAAAAGAGAAGAAAGCAAACCAAGAACCTCTCTGATGG
CGTTTCTCAGACAAATGTCAGTGAAAGGGGATGGAGGGATCACCCACTCAGAAGAAATAAATGGGAAAGACTCCAGCTGCCAAACATCAGACTCCACAGA
AAAGACTATCACACCGCCAGAGCCTGAACCAACAGGAGCACCACAGAAGGGTAAAGAGGGCTCCTCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAG
CAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCCCAGTGCACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGAATGGGGACAAGCTCCAAAAGA
GACCTGAGAAGCGGCAGCAGTCCCTTGGGGGCTTCTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAAACAGACCCAGTATCCATCGG
ACCAGTTGGCAAATCCAAGTAAACAAATCAGCACGGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTTCTCCTTACTCCATCTCCTCCCCAAACACGC
TCCATGTATATATTCTTCTGATGGCCAGCAAATGAAATTCTGCCTAGAAATTAAGCCCGAGCTGTTGTATATTGAGGTGTATTATTTACGTCTCTGGTCC
AGTCTTTTCTGGCAAATAACAGTAAAGATGGTTTAGCAGGTCACCTAGTTGGGTCAGAAGAGTCGATGATCACCAAGCAGGAAAGGGAGGGAATAGAGGA
ATGTGTTCGGGTTAAGTGATGAAAATGGCAGTGGTGGCCGGGCGTGGTGGCTCTCGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACC
TGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACATCATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTAGTC
CCAGCTACTCGGGAGCCCAACGCACGAGAACCGCTTGTACCCAGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGCACCATTGCACTCCACCCTGGGCGACA
GAGCAAGATTCTATCAAAAAAAAAAAAAGGCAGTGGCAAGTAAGTTATAGAAGAGAAATGCTGCTAGAAGGAATTAAGCGTTGTAGTAAATGCGTGCTTA
TCCTCTAAGCTTGAAGAAGGGAGACGAAAATCCATTTGTTTAAATTCACATCTCAAGGAGGGAGAACCCGGGCTGTGTTGGGTGGTTGCCAATTTCCTAG
AACGGAATGTGTGGGGTATAGAAAAAGGAATGAATAAGCGTTGTTTTTCAAATAGGGTCCTTGTAAGTTATTGATGAGAGGGAAAAGATTGACTGGGGAG
GGCTTAAAATGATTTGGGAAAACAATTGCTTTTGAGGCTCAGTGACAACGGCAAAGATTACAACTTAAAAAAAAAAAATAAATAAAAAATAAAGGAAGTT
GCACGGTTATTTTGCAACACAAGGGGGCGGCAAGGTCCCCATTTTTATCCTGTAATACTGTATCCCTAACAAAGATTTGGTCTCTGCTATCTTACATTAT
TAATGTTTCTCAGATGGCTGAGGGGCTCGCTTCATCTGTTCCGTCTGACACTTATCTCAAGTGTGTCTGTCATTCCTAATGTTCTCAGGATGTGCTCTGA
TAAAACCCTCCCCATAACCTCAGTTAATAAAAATTTACAGAAGACTTCTCAAATACCTGAGTTGTTTTTAATACCTGTACAAAGGAGTAAATAGGACCCT
GAGTCTATTAAAATGTAATTCAAAGTAGCATATGATTGACTGACAGTCATGTAAACTGTATCTTTCTTTTTCTGATTTAATAAAAAATACATTTACTTCT
AAAGTATCTTTTAATTTTCAACTTCAAAGCAGTCCCACTCTATATCTGAGATGACTCTAACTTCTACATTATAAAATCCATACTCTTTCTCCATTATCTT
CTTTGGAAGATCATTCTCTCCCAGATCTTCCCGGATTTCCTTGTATATGGGCACACACACACACAAATGTGTGCAGTTGTATGTTTGCATGTACACACAC
ATGCATGTATAGAATAGTGCTGTCTTAGGCCAGGTTGCTTGGAGCAGAGCCTGAGATGGGGATTTGGACGCATAGGATATACTGAGAGTGGGCTCCGAGG
GAAAGGGAGTAAGAGAAAAAGAAGAGGGCAAGAAAAGAGTTGGGCAAGGGTTGGTTTCAACTGGAGCATGAATTGCACCACCCAGATAGTTTGACCTTGA
GTCAAGGGAGCCAGCCTTTGAACCCTGGTAGGTGAATTCTGGGCTGCCCTGGGAGGTGGGGGG
  • BCAS1.F2 (forward primer)
  • BCAS1.R1 (reverse primer)
  • Single exon skipping

Frame 0

VFSQQALHKEAKCREPGSTDSQALGSTHWRPRT
LCRSSSG*HEGTEDTPTGAQQEQWVTK*VFPKEL
KTKRMNQKQRLTRTTRLL*TGFQWWCRPTQFST
*RKSTWE*VSRRIMWPLLPPRQRR*VLLRMPTE
RILGKRPNPRHQLLNLVFS*CSLGLYQDVPETKP
QIHPLDQ*SLMSAPIKLQRTKTQVRAGHFRWQL
DRGRTQIKPQGTPRPKTRSSLPPGIPRFSHLRQ
GEQEEKLPPSPRTPAFLTNSSSWTRDRKRCQVTA
NRKPRGQSIKTRWMRFLAYQGSPMMSLQGRT*L
TARKKKDKNLELRIALSLGTQKDWRLQRTIPRQ
QL*QRIIIPS*VSLKLWFHLTKLKQKRTQKTRVL
KSHPPLQLTLSQTKPTLHPRRPKGLARIPKDAT
HRGTHSP*QPLNLRRKAPRRNQDPPLCLWANCF
GKSQLKRTQSPQVRRRMWCVSHQ*RL*SPRK*NQ
PYKQWTSTKEMLHLNPQKRNSKEKKANQEPL*W
RFSDKCQ*KGMEGSPTQKK*MGKTPAAKHQTPQ
KRLSHRQSLNQQEHHRRVKRAPRRTRSQQPR*TS
RRATSRKPKNQPSAQSRPRWTRTHCRMGTSSKR
DLRSGSSPLGASLKAWDQSGCWMLKCKQTQYPS
DQLANPSKQISTVPTRFSCHQDVFSLLHLLPKHA
PCIYSSDGQQMKFCLEIKPELLYIEVYYLRLWS
SLFWQITVKMV*QVT*LGQKSR*SPSRKGRE*R
NVFGLSDENGSGGRAWWLSPVISALWEAEAGGSP
EVRSSRLAWPTS*NPVSTKNTKISQAWWHTPVV
PATREPNAREPLVPRRWRLQ*AEVAPLHSTLGD
RARFYQKKKKAVASKL*KRNAARRN*AL**MRAY
PLSLKKGDENPFV*IHISRRENPGCVGWLPIS*
NGMCGV*KKE*ISVVFQIGSL*VIDEREKIDWG
GLKMIWENNCF*GSVTTAKITT*KKKINKK*RKL
HGYFATQGGGKVPIFIL*YCIPNKDLVSAILHY
*CFSDG*GARFICSV*HLSQVCLSFLMFSGCAL
IKPSP*PQLIKIYRRLLKYLSCF*YLYKGVNRTL
SLLKCNSK*HMID*QSCKLYLSFSDLIKNTFTS
KVSFNFQLQSSPTLYLR*L*LLHYKIHTLSPLS
SLEDHSLPDLPGFPCIWAHTHTNVCSCMFACTHT
CMYRIVLS*ARLLGAEPEMGIWTHRIY*EWAPR
ERE*EKKKRARKELGKGWFQLEHELHHPDSLTL
SQGSQPLNPGR*ILGCPGRWG

Frame 1

YSASRLCTRKQSAGSQAPPTARHWAARTGDPGP
CAGAAPGDTRGLKILPQGLSRSNG*PNECSPKS
*RPRE*TRSRDLPGQRVCSERGSSGGVDPHSSAL
RGSRLGNKCQDG*CGHFFPRDNGDKCCCGCQRK
ESWERGQTRGTSC*ISFFLDALSACTRTYRRPS
RRFIPWISEA*CQLQ*SSSEQRPK*ELDTSGGSW
TGAGHR*NPRARPGPRQGPLCRQGSHASPT*DR
GSRRRSSLQAQGLQLF*QILQAGQGTGKGAR*Q
PTGSQEGRASRQGG*GSWLIRAVR*CPCREGHS*
RQGKRRTRTWNCGLLCPWGPRRTGDCKGRFPGS
SYSRE**FHHEFL*NSGFT*QS*NKKGPRRHGC
*KVTHHFS*P*VRQSQLYIPGDPRGWQEFQRMQP
IGAHTVRDNP*TCEGRHQGEIRTHLSASGQTVL
EKVS*RGLSPHRCGGECGV*VTSRDYKVQGSRI
SLTNSGPQRRRCCT*THRSETQKRRKQTKNLSDG
VSQTNVSERGWRDHPLRRNKWERLQLPNIRLHR
KDYHTARA*TNRSTTEG*RGLLEGQEVSSRDEQ
AEEQQAGSQRTSPVHRAGHGGHELTAEWGQAPKE
T*EAAAVPWGLL*RPGTKADVGCSSANRPSIHR
TSWQIQVNKSARFPPGSPATKMCSPYSISSPNT
LHVYILLMASK*NSA*KLSPSCCILRCIIYVSGP
VFSGK*Q*RWFSRSPSWVRRVDDHQAGKGGNRG
MCSG*VMKMAVVAGRGGSRL*SQHFGRPRQVDH
LRSGVQD*PGQHHETPSLLKIQKLARHGGTHL*S
QLLGSPTHENRLYPGGGGCSEPKLHHCTPPWAT
EQDSIKKKKRQWQVSYRREMLLEGIKRCSKCVL
IL*A*RRETKIHLFKFTSQGGRTRAVLGGCQFPR
TECVGYRKRNE*ALFFK*GPCKLLMRGKRLTGE
GLK*FGKTIAFEAQ*QRQRLQLKKKK*IKNKGS
CTVILQHKGAARSPFLSCNTVSLTKIWSLLSYII
NVSQMAEGLASSVPSDTYLKCVCHS*CSQDVL*
*NPPHNLS**KFTEDFSNT*VVFNTCTKE*IGP
*VY*NVIQSSI*LTDSHVNCIFLFLI**KIHLLL
KYLLIFNFKAVPLYI*DDSNFYIIKSILFLHYL
LWKIILSQIFPDFLVYGHTHTQMCAVVCLHVHT
HACIE*CCLRPGCLEQSLRWGFGRIGYTESGLRG
KGSKRKRRGQEKSWARVGFNWSMNCTTQIV*P*
VKGASL*TLVGEFWAALGGGG

Frame 2

IQPAGSAQGSKVQGARLHRQPGTGQHALETQDP
VQEQLRVTRGD*RYSHRGSAGAMGNQMSVPQRV
EDQENEPEAETYQDNASALNGVPVVVSTHTVQH
LEEVDLGISVKTDNVATSSPETTEISAVADANGK
NLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQA
ADSSLGSVKLDVSSNKAPANKDPSESWTLPVAA
GPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETG
GAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDS
QQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIV
DGKEKEGQELGTADCSVPGDPEGLETAKDDSQAA
AIAENNNSIMSFFKTLVSPNKAETKKDPEDTGA
EKSPTTSADLKSDKANFTSQETQGAGKNSKGCN
PSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFW
KKSVKEDSVPTGAEENVVCESPVEIIKSKEVES
ALQTVDLNEGDAAPEPTEAKLKREESKPRTSLM
AFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTE
KTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNK
QKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQK
RPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIG
PVGKSK*TNQHGSHQVLLPPRCVLLTPSPPQTR
SMYIFF*WPANEILPRN*ARAVVY*GVLFTSLV
QSFLANNSKDGLAGHLVGSEESMITKQEREGIEE
CVRVK**KWQWWPGVVALACNLSTLGGRGRWIT
*GQEFKTSLANIMKPRLY*KYKN*PGMVAHTCS
PSYSGAQRTRTACTQEVEVAVSRSCTIALHPGRQ
SKILSKKKKGSGK*VIEEKCC*KELSVVVNACL
SSKLEEGRRKSICLNSHLKEGEPGLCWVVANFL
ERNVWGIEKGMNKRCFSNRVLVSY**EGKD*LGR
A*NDLGKQLLLRLSDNGKDYNLKKKNK*KIKEV
ARLFCNTRGRQGPHFYPVILYP*QRFGLCYLTL
LMFLRWLRGSLHLFRLTLISSVSVIPNVLRMCSD
KTLPITSVNKNLQKTSQIPELFLIPVQRSK*DP
ESIKM*FKVAYD*LTVM*TVSFFF*FNKKYIYF
*SIF*FSTSKQSHSISEMTLTSTL*NPYSFSIIF
FGRSFSPRSSRISLYMGTHTHKCVQLYVCMYTH
MHV*NSAVLGQVAWSRA*DGDLDA*DILRVGSE
GKGVREKEEGKKRVGQGLVSTGA*IAPPR*FDLE
SREPAFEPW*VNSGLPWEVG

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