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Sequences

Sequence PCSK6.hAug05

TCGCGGGCCGAGGACGCCTCTGGGGCGGCACCGCGTCCCGAGAGCCCCAGAAGTCGGCGGGGAAGTTCCCCCGGTGGGGGGCGTTTCGGGCCTCCCGGAC GGCTCTCGGCCCCGGAGCCCGGTCGCAGGAGCGCGGGCCCGGGGGCGGGAACGCGCCGCGGCCGCCTCCTCCTCCCCGGCTCCCGCCCGCGGCGGTGTTG GCGGCGGCGGTGGCGGCGGCGGCGGCGCTTCCCCGGCGCGGAGCGGCTTTAAAAGGCGGCACTCCACCCCCCGGCGCACTCGCAGCTCGGGCGCCGCGCG AGCCTGTCGCCGCTATGCCTCCGCGCGCGCCGCCTGCGCCCGGGCCCCGGCCGCCGCCCCGGGCCGCCGCCGCCACCGACACCGCCGCGGGCGCGGGGGG CGCGGGGGGCGCGGGGGGCGCCGGCGGGCCCGGGTTCCGGCCGCTCGCGCCGCGTCCCTGGCGCTGGCTGCTGCTGCTGGCGCTGCCTGCCGCCTGCTCC GCCCCCGCCGCGCCCCGTCTACACCAACCACTGGGCGGTGCAAGTGCTGGGCGGCCCGGCCGAGGCGGACCGCGTGGCGGCGGCGCACGGGTACCTCAAC TTGGGCCAGATTGGAAACCTGGAAGATTACTACCATTTTTATCACAGCAAAACCTTTAAAAGATCAACCTTGAGTAGCAGAGGCCCTCACACCTTCCTCA GAATGGACCCCCAGGTGAAATGGCTCCAGCAACAGGAAGTGAAACGAAGGGTGAAGAGACAGGTGCGAAGTGACCCGCAGGCCCTTTACTTCAACGACCC CATTTGGTCCAACATGTGGTACCTGCATTGTGGCGACAAGAACAGTCGCTGCCGGTCGGAAATGAATGTCCAGGCAGCGTGGAAGAGGGGCTACACAGGA AAAAACGTGGTGGTCACCATCCTTGATGATGGCATAGAGAGAAATCACCCTGACCTGGCCCCAAATTATGATTCCTACGCCAGCTACGACGTGAACGGCA ATGATTATGACCCATCTCCACGATATGATGCCAGCAATGAAAATAAACACGGCACTCGTTGTGCGGGAGAAGTTGCTGCTTCAGCAAACAATTCCTACTG CATCGTGGGCATAGCGTACAATGCCAAAATAGGAGGCATCCGCATGCTGGACGGCGATGTCACAGATGTGGTCGAGGCAAAGTCGCTGGGCATCAGACCC AACTACATCGACATTTACAGTGCCAGCTGGGGGCCGGACGACGACGGCAAGACGGTGGACGGGCCCGGCCGACTGGCTAAGCAGGCTTTCGAGTATGGCA TTAAAAAGGGCCGGCAGGGCCTGGGCTCCATTTTCGTCTGGGCATCTGGGAATGGCGGGAGAGAGGGGGACTACTGCTCGTGCGATGGCTACACCAACAG CATCTACACCATCTCCGTCAGCAGCGCCACCGAGAATGGCTACAAGCCCTGGTACCTGGAAGAGTGTGCCTCCACCCTGGCCACCACCTACAGCAGTGGG GCCTTTTATGAGCGAAAAATCGTCACCACGGATCTGCGTCAGCGCTGTACCGATGGCCACACTGGGACCTCAGTCTCTGCCCCCATGGTGGCGGGCATCA TCGCCTTGGCTCTAGAAGCAAACAGCCAGTTAACCTGGAGGGACGTCCAGCACCTGCTAGTGAAGACATCCCGGCCGGCCCACCTGAAAGCGAGCGACTG GAAAGTGAACGGCGCGGGTCATAAAGTTAGCCATTTCTATGGATTTGGTTTGGTGGACGCAGAAGCTCTCGTTGTGGAGGCAAAGAAGTGGACAGCAGTG CCATCGCAGCACATGTGTGTGGCCGCCTCGGACAAGAGACCCAGGAGCATCCCCTTAGTGCAGGTGCTGCGGACTACGGCCCTGACCAGCGCCTGCGCGG AGCACTCGGACCAGCGGGTGGTCTACTTGGAGCACGTGGTGGTTCGCACCTCCATCTCACACCCACGCCGAGGAGACCTCCAGATCTACCTGGTTTCTCC CTCGGGAACCAAGTCTCAACTTCTGGCAAAGAGGTTGCTGGATCTTTCCAATGAAGGGTTTACAAACTGGGAATTCATGACTGTCCACTGCTGGGGAGAA AAGGCTGAAGGGCAGTGGACCTTGGAAATCCAAGATCTGCCATCCCAGGTCCGCAACCCGGAGAAGCAAGGGAACCTGGACTAAAACACGTGTTCCGGTG GCAGATTGAACAAGAGCTTTGGTAATCTCTGTGAAATACTGCAGAGGGACAGATGACCAAAGCCACCACATTTAGAACTTTGGCTGCCTTTGGAAGTCCA GAGCTGGATCTCTCAGCTCCCGCCCCCAGAGGCTCAGCACTTTGGACATGGCTCACAAACAGTTGTTGATTGACTGCATGAATGCGTGTGCGTGCAAGCA TGAACCTTGTTTAAATCAAGAGCTTACATAATTTTAACCAGTTCTGTCTTCAGCTGTACATACTCAGTAAAATGTTTAATGAAGGGGAAGAGATTAGTCT CTTCTGTGTGACCATGTTTTCCCTTTATTCATCCTAAAAAGTTCCATGAATTCTTGATTTCCTTTCAGTGGCCCTTTCAACAATGTCTTTTTTCCCAAGA GCATAACTGTTCTCATTTTATTGCTAGCCATCTTGATCTGTGTTTTATTGACATCTCTTTTGAGCTAATCTTCATTTCTAAGATAAGAGTTGAGATTTTG CAATCTGTGTTCGATGGCTCAATCTATCCTGTGCTTGATGCTAGAAAGGAAGACAGATTTAAAGCACATGCCTTCTGTGCCGGCTTTCAAGTTTGTCACT AAACTCTCATTTCTGGAAAGTGCAATTATAGAGTATCACTCCCACTTCCTTGGAAACAGAGCTGAAGAACTTGGCACACTCTCCAAACAGTCACCATACA CACTGTTGTCAAAAAGTTCCATTTTTAACCCCATTTGCATTAATATTGCAGTCAATCTCTTTACCTCCTTTTCTCTTTCACGGGGCCGTGACAGTGACGC CTTTCCCCAAAACTCTCCTCGTTTGAGAAAAAAAGAAGTATGTATCCCCACTTATCTCGGGGAGAAATGCAACCAACTGCTGCTGTGCACATTTATGAAT CACAGTATTGTTTAGTCGGTTCTGTATCTCCAGTAGAAAGCATAACAAAAAGATGACCTTTGTCTCACCTCATAGCTAATTTTTGCAAATAAAATACTAA ACATTGATGAAAATGAAAATGACAGATCTGAGGAAGAGGGAGAGCTCTCTTGAAACCCCTTTCCCAGATTTGCCCTCAGTTTTAGGAATGAGGTACGCTT GGGCATTCCTGTTGCCTGCATGGTTCGGCATTCTGGCAGCCAGGTTCGCCCCAGAATAGATAAGTGTGTTTGATTTTCGAACATTTGACTTTATTACCTA TTTCCAGAAACACTTCGTGTTCAAACTACGTCTCTACAGGCATTTCTACTTGGTCTTTTTCTCCCCTGACATTTCACAGAGTCCTAACTGTGCTGCATGT ATAACTTGTTCTTTCTTTTTGTTACTTGCATAGCAAGCATGTTTCTATGTCATTAAATATCCTTTGTAAGCAGC

PCSK6.F3 (forward primer)
PCSK6.R3 (reverse primer)
Single exon skipping

Frame 0

SRAEDASGAAPRPESPRSRRGSSPGGGRFGPPG RLSAPEPGRRSAGPGAGTRRGRLLLPGSRPRRCW RRRWRRRRRFPGAERL*KAALHPPAHSQLGRRA SLSPLCLRARRLRPGPGRRPGPPPPPTPPRARG ARGARGAPAGPGSGRSRRVPGAGCCCWRCLPPAP PPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLN LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFL RMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTG KNVVVTILDDGIERNHPDLAPNYDSYASYDVNG NDYDPSPRYDASNENKHGTRCAGEVAASANNSYC IVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRP NYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYG IKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNS IYTISVSSATENGYKPWYLEECASTLATTYSSG AFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGI IALALEANSQLTWRDVQHLLVKTSRPAHLKASDW KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAV PSQHMCVAASDKRPRSIPLVQVLRTTALTSACA EHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSP SGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGE KAEGQWTLEIQDLPSQVRNPEKQGNLD*NTCSG GRLNKSFGNLCEILQRDR*PKPPHLELWLPLEVQ SWISQLPPPEAQHFGHGSQTVVD*LHECVCVQA *TLFKSRAYIILTSSVFSCTYSVKCLMKGKRLV SSV*PCFPFIHPKKFHEFLISFQWPFQQCLFSQE HNCSHFIASHLDLCFIDISFELIFISKIRVEIL QSVFDGSIYPVLDARKEDRFKAHAFCAGFQVCH *TLISGKCNYRVSLPLPWKQS*RTWHTLQTVTIH TVVKKFHF*PHLH*YCSQSLYLLFSFTGP*Q*R LSPKLSSFEKKRSMYPHLSRGEMQPTAAVHIYE SQYCLVGSVSPVESITKR*PLSHLIANFCK*NTK H**K*K*QI*GRGRALLKPLSQICPQF*E*GTL GHSCCLHGSAFWQPGSPQNR*VCLIFEHLTLLP ISRNTSCSNYVSTGISTWSFSPLTFHRVLTVLHV *LVLSFCYLHSKHVSMSLNILCKQ

Frame 1

RGPRTPLGRHRVPRAPEVGGEVPPVGGVSGLPD GSRPRSPVAGARARGRERAAAASSSPAPARGGV GGGGGGGGGASPARSGFKRRHSTPRRTRSSGAAR ACRRYASARAACARAPAAAPGRRRHRHRRGRGG RGGRGGRRRARVPAARAASLALAAAAGAACRLL RPRRAPSTPTTGRCKCWAARPRRTAWRRRTGTST WARLETWKITTIFITAKPLKDQP*VAEALTPSS EWTPR*NGSSNRK*NEG*RDRCEVTRRPFTSTT PFGPTCGTCIVATRTVAAGRK*MSRQRGRGATQE KTWWSPSLMMA*REITLTWPQIMIPTPATT*TA MIMTHLHDMMPAMKINTALVVREKLLLQQTIPT ASWA*RTMPK*EASACWTAMSQMWSRQSRWASDP TTSTFTVPAGGRTTTARRWTGPADWLSRLSSMA LKRAGRAWAPFSSGHLGMAGERGTTARAMATPT ASTPSPSAAPPRMATSPGTWKSVPPPWPPPTAVG PFMSEKSSPRICVSAVPMATLGPQSLPPWWRAS SPWL*KQTAS*PGGTSSTC**RHPGRPT*KRAT GK*TARVIKLAISMDLVWWTQKLSLWRQRSGQQC HRSTCVWPPRTRDPGASP*CRCCGLRP*PAPAR STRTSGWSTWSTWWFAPPSHTHAEETSRSTWFL PREPSLNFWQRGCWIFPMKGLQTGNS*LSTAGEK RLKGSGPWKSKICHPRSATRRSKGTWTKTRVPV AD*TRALVISVKYCRGTDDQSHHI*NFGCLWKS RAGSLSSRPQRLSTLDMAHKQLLIDCMNACACKH EPCLNQELT*F*PVLSSAVHTQ*NV**RGRD*S LLCDHVFPLFILKSSMNS*FPFSGPFNNVFFPK SITVLILLLAILICVLLTSLLS*SSFLR*ELRFC NLCSMAQSILCLMLERKTDLKHMPSVPAFKFVT KLSFLESAIIEYHSHFLGNRAEELGTLSKQSPY TLLSKSSIFNPICINIAVNLFTSFSLSRGRDSDA FPQNSPRLRKKEVCIPTYLGEKCNQLLLCTFMN HSIV*SVLYLQ*KA*QKDDLCLTS*LIFANKIL NIDENENDRSEEEGELS*NPFPRFALSFRNEVRL GIPVACMVRHSGSQVRPRIDKCV*FSNI*LYYL FPETLRVQTTSLQAFLLGLFLP*HFTES*LCCM YNLFFLFVTCIASMFLCH*ISFVSS

Frame 2

AGRGRLWGGTASREPQKSAGKFPRWGAFRASRT ALGPGARSQERGPGGGNAPRPPPPPRLPPAAVL AAAVAAAAALPRRGAALKGGTPPPGALAARAPR EPVAAMPPRAPPAPGPRPPPRAAAATDTAAGAGG AGGAGGAGGPGFRPLAPRPWRWLLLLALPAACS APAAPRLHQPLGGASAGRPGRGGPRGGGARVPQ LGPDWKPGRLLPFLSQQNL*KINLE*QRPSHLPQ NGPPGEMAPATGSETKGEETGAK*PAGPLLQRP HLVQHVVPALWRQEQSLPVGNECPGSVEEGLHR KKRGGHHP**WHREKSP*PGPKL*FLRQLRRERQ *L*PISTI*CQQ*K*TRHSLCGRSCCFSKQFLL HRGHSVQCQNRRHPHAGRRCHRCGRGKVAGHQT QLHRHLQCQLGAGRRRQDGGRARPTG*AGFRVWH *KGPAGPGLHFRLGIWEWRERGGLLLVRWLHQQ HLHHLRQQRHREWLQALVPGRVCLHPGHHLQQW GLL*AKNRHHGSASALYRWPHWDLSLCPHGGGHH RLGSRSKQPVNLEGRPAPASEDIPAGPPESERL ESERRGS*S*PFLWIWFGGRRSSRCGGKEVDSS AIAAHVCGRLGQETQEHPLSAGAADYGPDQRLRG ALGPAGGLLGARGGSHLHLTPTPRRPPDLPGFS LGNQVSTSGKEVAGSFQ*RVYKLGIHDCPLLGR KG*RAVDLGNPRSAIPGPQPGEAREPGLKHVFRW QIEQELW*SL*NTAEGQMTKATTFRTLAAFGSP ELDLSAPAPRGSALWTWLTNSC*LTA*MRVRAS MNLV*IKSLHNFNQFCLQLYILSKMFNEGEEISL FCVTMFSLYSS*KVP*ILDFLSVALSTMSFFPR A*LFSFYC*PS*SVFY*HLF*ANLHF*DKS*DF AICVRWLNLSCA*C*KGRQI*STCLLCRLSSLSL NSHFWKVQL*SITPTSLETELKNLAHSPNSHHT HCCQKVPFLTPFALILQSISLPPFLFHGAVTVT PFPKTLLV*EKKKYVSPLISGRNATNCCCAHL*I TVLFSRFCISSRKHNKKMTFVSPHS*FLQIKY* TLMKMKMTDLRKRESSLETPFPDLPSVLGMRYA WAFLLPAWFGILAARFAPE*ISVFDFRTFDFITY FQKHFVFKLRLYRHFYLVFFSPDISQSPNCAAC ITCSFFLLLA*QACFYVIKYPL*A

Sequence PCSK6.gAug05

TCGCGGGCCGAGGACGCCTCTGGGGCGGCACCGCGTCCCGAGAGCCCCAGAAGTCGGCGGGGAAGTTCCCCCGGTGGGGGGCGTTTCGGGCCTCCCGGAC GGCTCTCGGCCCCGGAGCCCGGTCGCAGGAGCGCGGGCCCGGGGGCGGGAACGCGCCGCGGCCGCCTCCTCCTCCCCGGCTCCCGCCCGCGGCGGTGTTG GCGGCGGCGGTGGCGGCGGCGGCGGCGCTTCCCCGGCGCGGAGCGGCTTTAAAAGGCGGCACTCCACCCCCCGGCGCACTCGCAGCTCGGGCGCCGCGCG AGCCTGTCGCCGCTATGCCTCCGCGCGCGCCGCCTGCGCCCGGGCCCCGGCCGCCGCCCCGGGCCGCCGCCGCCACCGACACCGCCGCGGGCGCGGGGGG CGCGGGGGGCGCGGGGGGCGCCGGCGGGCCCGGGTTCCGGCCGCTCGCGCCGCGTCCCTGGCGCTGGCTGCTGCTGCTGGCGCTGCCTGCCGCCTGCTCC GCCCCCGCCGCGCCCCGTCTACACCAACCACTGGGCGGTGCAAGTGCTGGGCGGCCCGGCCGAGGCGGACCGCGTGGCGGCGGCGCACGGGTACCTCAAC TTGGGCCAGATTGGAAACCTGGAAGATTACTACCATTTTTATCACAGCAAAACCTTTAAAAGATCAACCTTGAGTAGCAGAGGCCCTCACACCTTCCTCA GAATGGACCCCCAGGTGAAATGGCTCCAGCAACAGGAAGTGAAACGAAGGGTGAAGAGACAGGTGCGAAGTGACCCGCAGGCCCTTTACTTCAACGACCC CATTTGGTCCAACATGTGGTACCTGCATTGTGGCGACAAGAACAGTCGCTGCCGGTCGGAAATGAATGTCCAGGCAGCGTGGAAGAGGGGCTACACAGGA AAAAACGTGGTGGTCACCATCCTTGATGATGGCATAGAGAGAAATCACCCTGACCTGGCCCCAAATTATGATTCCTACGCCAGCTACGACGTGAACGGCA ATGATTATGACCCATCTCCACGATATGATGCCAGCAATGAAAATAAACACGGCACTCGTTGTGCGGGAGAAGTTGCTGCTTCAGCAAACAATTCCTACTG CATCGTGGGCATAGCGTACAATGCCAAAATAGGAGGCATCCGCATGCTGGACGGCGATGTCACAGATGTGGTCGAGGCAAAGTCGCTGGGCATCAGACCC AACTACATCGACATTTACAGTGCCAGCTGGGGGCCGGACGACGACGGCAAGACGGTGGACGGGCCCGGCCGACTGGCTAAGCAGGCTTTCGAGTATGGCA TTAAAAAGGGCCGGCAGGGCCTGGGCTCCATTTTCGTCTGGGCATCTGGGAATGGCGGGAGAGAGGGGGACTACTGCTCGTGCGATGGCTACACCAACAG CATCTACACCATCTCCGTCAGCAGCGCCACCGAGAATGGCTACAAGCCCTGGTACCTGGAAGAGTGTGCCTCCACCCTGGCCACCACCTACAGCAGTGGG GCCTTTTATGAGCGAAAAATCGTCACCACGGATCTGCGTCAGCGCTGTACCGATGGCCACACTGGGACCTCAGTCTCTGCCCCCATGGTGGCGGGCATCA TCGCCTTGGCTCTAGAAGCAAACAGCCAGTTAACCTGGAGGGACGTCCAGCACCTGCTAGTGAAGACATCCCGGCCGGCCCACCTGAAAGCGAGCGACTG GAAAGTGAACGGCGCGGGTCATAAAGTTAGCCATTTCTATGGATTTGGTTTGGTGGACGCAGAAGCTCTCGTTGTGGAGGCAAAGAAGTGGACAGCAGTG CCATCGCAGCACATGTGTGTGGCCGCCTCGGACAAGAGACCCAGGAGCATCCCCTTAGTGCAGGTGCTGCGGACTACGGCCCTGACCAGCGCCTGCGCGG AGCACTCGGACCAGCGGGTGGTCTACTTGGAGCACGTGGTGGTTCGCACCTCCATCTCACACCCACGCCGAGGAGACCTCCAGATCTACCTGGTTTCTCC CTCGGGAACCAAGTCTCAACTTCTGGCAAAGAGGTTGCTGGATCTTTCCAATGAAGGGTTTACAAACTGGGAATTCATGACTGTCCACTGCTGGGGAGAA AAGGCTGAAGGGCAGTGGACCTTGGAAATCCAAGATCTGCCATCCCAGGTCCGCAACCCGGAGAAGCAAGGTGATCTTGAGACTCCTGTTGCAAATCAAC TGACCACAGAAGAGAGGGAACCTGGACTAAAACACGTGTTCCGGTGGCAGATTGAACAAGAGCTTTGGTAATCTCTGTGAAATACTGCAGAGGGACAGAT GACCAAAGCCACCACATTTAGAACTTTGGCTGCCTTTGGAAGTCCAGAGCTGGATCTCTCAGCTCCCGCCCCCAGAGGCTCAGCACTTTGGACATGGCTC ACAAACAGTTGTTGATTGACTGCATGAATGCGTGTGCGTGCAAGCATGAACCTTGTTTAAATCAAGAGCTTACATAATTTTAACCAGTTCTGTCTTCAGC TGTACATACTCAGTAAAATGTTTAATGAAGGGGAAGAGATTAGTCTCTTCTGTGTGACCATGTTTTCCCTTTATTCATCCTAAAAAGTTCCATGAATTCT TGATTTCCTTTCAGTGGCCCTTTCAACAATGTCTTTTTTCCCAAGAGCATAACTGTTCTCATTTTATTGCTAGCCATCTTGATCTGTGTTTTATTGACAT CTCTTTTGAGCTAATCTTCATTTCTAAGATAAGAGTTGAGATTTTGCAATCTGTGTTCGATGGCTCAATCTATCCTGTGCTTGATGCTAGAAAGGAAGAC AGATTTAAAGCACATGCCTTCTGTGCCGGCTTTCAAGTTTGTCACTAAACTCTCATTTCTGGAAAGTGCAATTATAGAGTATCACTCCCACTTCCTTGGA AACAGAGCTGAAGAACTTGGCACACTCTCCAAACAGTCACCATACACACTGTTGTCAAAAAGTTCCATTTTTAACCCCATTTGCATTAATATTGCAGTCA ATCTCTTTACCTCCTTTTCTCTTTCACGGGGCCGTGACAGTGACGCCTTTCCCCAAAACTCTCCTCGTTTGAGAAAAAAAGAAGTATGTATCCCCACTTA TCTCGGGGAGAAATGCAACCAACTGCTGCTGTGCACATTTATGAATCACAGTATTGTTTAGTCGGTTCTGTATCTCCAGTAGAAAGCATAACAAAAAGAT GACCTTTGTCTCACCTCATAGCTAATTTTTGCAAATAAAATACTAAACATTGATGAAAATGAAAATGACAGATCTGAGGAAGAGGGAGAGCTCTCTTGAA ACCCCTTTCCCAGATTTGCCCTCAGTTTTAGGAATGAGGTACGCTTGGGCATTCCTGTTGCCTGCATGGTTCGGCATTCTGGCAGCCAGGTTCGCCCCAG AATAGATAAGTGTGTTTGATTTTCGAACATTTGACTTTATTACCTATTTCCAGAAACACTTCGTGTTCAAACTACGTCTCTACAGGCATTTCTACTTGGT CTTTTTCTCCCCTGACATTTCACAGAGTCCTAACTGTGCTGCATGTATAACTTGTTCTTTCTTTTTGTTACTTGCATAGCAAGCATGTTTCTATGTCATT AAATATCCTTTGTAAGCAGC

PCSK6.F3 (forward primer)
PCSK6.R3 (reverse primer)
Single exon skipping

Frame 0

SRAEDASGAAPRPESPRSRRGSSPGGGRFGPPG RLSAPEPGRRSAGPGAGTRRGRLLLPGSRPRRCW RRRWRRRRRFPGAERL*KAALHPPAHSQLGRRA SLSPLCLRARRLRPGPGRRPGPPPPPTPPRARG ARGARGAPAGPGSGRSRRVPGAGCCCWRCLPPAP PPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLN LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFL RMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTG KNVVVTILDDGIERNHPDLAPNYDSYASYDVNG NDYDPSPRYDASNENKHGTRCAGEVAASANNSYC IVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRP NYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYG IKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNS IYTISVSSATENGYKPWYLEECASTLATTYSSG AFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGI IALALEANSQLTWRDVQHLLVKTSRPAHLKASDW KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAV PSQHMCVAASDKRPRSIPLVQVLRTTALTSACA EHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSP SGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGE KAEGQWTLEIQDLPSQVRNPEKQGDLETPVANQ LTTEEREPGLKHVFRWQIEQELW*SL*NTAEGQM TKATTFRTLAAFGSPELDLSAPAPRGSALWTWL TNSC*LTA*MRVRASMNLV*IKSLHNFNQFCLQ LYILSKMFNEGEEISLFCVTMFSLYSS*KVP*IL DFLSVALSTMSFFPRA*LFSFYC*PS*SVFY*H LF*ANLHF*DKS*DFAICVRWLNLSCA*C*KGR QI*STCLLCRLSSLSLNSHFWKVQL*SITPTSLE TELKNLAHSPNSHHTHCCQKVPFLTPFALILQS ISLPPFLFHGAVTVTPFPKTLLV*EKKKYVSPL ISGRNATNCCCAHL*ITVLFSRFCISSRKHNKKM TFVSPHS*FLQIKY*TLMKMKMTDLRKRESSLE TPFPDLPSVLGMRYAWAFLLPAWFGILAARFAP E*ISVFDFRTFDFITYFQKHFVFKLRLYRHFYLV FFSPDISQSPNCAACITCSFFLLLA*QACFYVI KYPL*A

Frame 1

RGPRTPLGRHRVPRAPEVGGEVPPVGGVSGLPD GSRPRSPVAGARARGRERAAAASSSPAPARGGV GGGGGGGGGASPARSGFKRRHSTPRRTRSSGAAR ACRRYASARAACARAPAAAPGRRRHRHRRGRGG RGGRGGRRRARVPAARAASLALAAAAGAACRLL RPRRAPSTPTTGRCKCWAARPRRTAWRRRTGTST WARLETWKITTIFITAKPLKDQP*VAEALTPSS EWTPR*NGSSNRK*NEG*RDRCEVTRRPFTSTT PFGPTCGTCIVATRTVAAGRK*MSRQRGRGATQE KTWWSPSLMMA*REITLTWPQIMIPTPATT*TA MIMTHLHDMMPAMKINTALVVREKLLLQQTIPT ASWA*RTMPK*EASACWTAMSQMWSRQSRWASDP TTSTFTVPAGGRTTTARRWTGPADWLSRLSSMA LKRAGRAWAPFSSGHLGMAGERGTTARAMATPT ASTPSPSAAPPRMATSPGTWKSVPPPWPPPTAVG PFMSEKSSPRICVSAVPMATLGPQSLPPWWRAS SPWL*KQTAS*PGGTSSTC**RHPGRPT*KRAT GK*TARVIKLAISMDLVWWTQKLSLWRQRSGQQC HRSTCVWPPRTRDPGASP*CRCCGLRP*PAPAR STRTSGWSTWSTWWFAPPSHTHAEETSRSTWFL PREPSLNFWQRGCWIFPMKGLQTGNS*LSTAGEK RLKGSGPWKSKICHPRSATRRSKVILRLLLQIN *PQKRGNLD*NTCSGGRLNKSFGNLCEILQRDR *PKPPHLELWLPLEVQSWISQLPPPEAQHFGHGS QTVVD*LHECVCVQA*TLFKSRAYIILTSSVFS CTYSVKCLMKGKRLVSSV*PCFPFIHPKKFHEF LISFQWPFQQCLFSQEHNCSHFIASHLDLCFIDI SFELIFISKIRVEILQSVFDGSIYPVLDARKED RFKAHAFCAGFQVCH*TLISGKCNYRVSLPLPW KQS*RTWHTLQTVTIHTVVKKFHF*PHLH*YCSQ SLYLLFSFTGP*Q*RLSPKLSSFEKKRSMYPHL SRGEMQPTAAVHIYESQYCLVGSVSPVESITKR *PLSHLIANFCK*NTKH**K*K*QI*GRGRALLK PLSQICPQF*E*GTLGHSCCLHGSAFWQPGSPQ NR*VCLIFEHLTLLPISRNTSCSNYVSTGISTW SFSPLTFHRVLTVLHV*LVLSFCYLHSKHVSMSL NILCKQ

Frame 2

AGRGRLWGGTASREPQKSAGKFPRWGAFRASRT ALGPGARSQERGPGGGNAPRPPPPPRLPPAAVL AAAVAAAAALPRRGAALKGGTPPPGALAARAPR EPVAAMPPRAPPAPGPRPPPRAAAATDTAAGAGG AGGAGGAGGPGFRPLAPRPWRWLLLLALPAACS APAAPRLHQPLGGASAGRPGRGGPRGGGARVPQ LGPDWKPGRLLPFLSQQNL*KINLE*QRPSHLPQ NGPPGEMAPATGSETKGEETGAK*PAGPLLQRP HLVQHVVPALWRQEQSLPVGNECPGSVEEGLHR KKRGGHHP**WHREKSP*PGPKL*FLRQLRRERQ *L*PISTI*CQQ*K*TRHSLCGRSCCFSKQFLL HRGHSVQCQNRRHPHAGRRCHRCGRGKVAGHQT QLHRHLQCQLGAGRRRQDGGRARPTG*AGFRVWH *KGPAGPGLHFRLGIWEWRERGGLLLVRWLHQQ HLHHLRQQRHREWLQALVPGRVCLHPGHHLQQW GLL*AKNRHHGSASALYRWPHWDLSLCPHGGGHH RLGSRSKQPVNLEGRPAPASEDIPAGPPESERL ESERRGS*S*PFLWIWFGGRRSSRCGGKEVDSS AIAAHVCGRLGQETQEHPLSAGAADYGPDQRLRG ALGPAGGLLGARGGSHLHLTPTPRRPPDLPGFS LGNQVSTSGKEVAGSFQ*RVYKLGIHDCPLLGR KG*RAVDLGNPRSAIPGPQPGEAR*S*DSCCKST DHRREGTWTKTRVPVAD*TRALVISVKYCRGTD DQSHHI*NFGCLWKSRAGSLSSRPQRLSTLDMA HKQLLIDCMNACACKHEPCLNQELT*F*PVLSSA VHTQ*NV**RGRD*SLLCDHVFPLFILKSSMNS *FPFSGPFNNVFFPKSITVLILLLAILICVLLT SLLS*SSFLR*ELRFCNLCSMAQSILCLMLERKT DLKHMPSVPAFKFVTKLSFLESAIIEYHSHFLG NRAEELGTLSKQSPYTLLSKSSIFNPICINIAV NLFTSFSLSRGRDSDAFPQNSPRLRKKEVCIPTY LGEKCNQLLLCTFMNHSIV*SVLYLQ*KA*QKD DLCLTS*LIFANKILNIDENENDRSEEEGELS* NPFPRFALSFRNEVRLGIPVACMVRHSGSQVRPR IDKCV*FSNI*LYYLFPETLRVQTTSLQAFLLG LFLP*HFTES*LCCMYNLFFLFVTCIASMFLCH *ISFVSS