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Sequence TPD52.fAug05
GGCGAAGGGGCTAGCGTCAGGGGCTGGCGGCCGTGATGCGCTTTGGGTGGAAAGCCGCGTGAAGGGAGCACGGCGCAGCCAGCTCCTGTAAGTGACTGGAACCAGGAACAGAGGACAGTGAGTCGCTCTCGTCCCTCCAGGTCTGCTGAGAACAGACCCAGTCCCTGAGGAAGGAGAAGATGTTGCTGCCACGATCAGTG
CCACAGAGACCCTCTCGGAAGAGGAGCAGGAAGAGCTAAGAAGAGAACTTGCAAAGGTAGAAGAAGAAATCCAGACTCTGTCTCAAGTGTTAGCAGCAAA
AGAGAAGCATCTAGCAGAGATCAAGCGGAAACTTGGAATCAATTCTCTACAGGAACTAAAACAGAACATTGCCAAAGGGTGGCAAGACGTGACAGCAACA
TCTGCTTACAAGAAGACATCTGAAACCTTATCCCAGGCTGGACAGAAGGCCTCAGCTGCTTTTTCGTCTGTTGGCTCAGTCATCACCAAAAAGCTGGAAG
ATGTAAATATACGTTCCATTCAGCATTCAATTAGCATGCCTGCTATGAGAAACTCCCCAACTTTTAAATCATTTGAAGAAAAGGTCGAAAACTTAAAGTC
TAAAGTAGGGGGAACCAAGCCTGCTGGTGGTGATTTTGGAGAAGTCTTGAATTCGGCTGCAAATGCTAGTGCCACCACCACGGAGCCTCTTCCAGAAAAG
ACACAGGAGAGCCTGTGAGATTCCTACCTTTGTTCTGCTACCCACTGCCAGATGCTGCAAGCGAGGTCCAAGCACATCTTGTCAACATGCATTGCCATGA
ATTTCTACCAGATGTGCTTTTATTTAGCTTTACATATTCCTTTGACCAAATAGTTTGTGGGTTAAACAAAATGAAAATATCTTCACCTCTATTCTTGGGA
AACACCCTTTAGTGTACATTTATGTTCCTTTATTTAGGAAACACCATTATAAAAACACTTATAGTAAATGGGGACATTCACTATAATGATCTAAGAAGCT
ACAGATTGTCATAGTTGTTTTCCTGCTTTACAAAATTGCTCCAGATCTGGAATGCCAGTTTGACCTTTGTCTTCTATAATATTTCCTTTTTTTCCCCTCT
TTGAATCTCTGTATATTTGATTCTTAACTAAAATTGTTCTCTTAAATATTCTGAATCCTGGTAATTAAAAGTTTGGGTGTATTTTCTTTACCTCCAAGGA
AAGAACTACTAGCTACAAAAAATATTTTGGAATAAGCATTGTTTTGGTATAAGGTACATATTTTGGTTGAAGACACCAGACTGAAGTAAACAGCTGTGCA
TCCAATTTATTATAGTTTTGTAAGTAACAATATGTAATCAAACTTCTAGGTGACTTGAGAGTGGAACCTCCTATATCATTATTTAGCACCGTTTGTGACA
GTAACCATTTCAGTGTATTGTTTATTATACCACTTATATCAACTTATTTTTCACCAGGTTAAAATTTTAATTTCTACAAAATAACATTCTGAATCAAGCA
CACTGTATGTTCAGTAGGTTGAACTATGAACACTGTCATCAATGTTCAGTTCAAAAGCCTGAAAGTTTAGATCTAGAAGCTGGTAAAAATGACAATATCA
ATCACATTAGGGGAACCATTGTTGTCTTCACTTAATCCATTTAGCACTATTTAAAATAAGCACACCAAGTTATATGACTAATATAACTTGAAAATTTTTT
ATACTGAGGGGTTGGTGATAACTCTTGAGGATGTAATGCATTAATAAAAATCAACTCATCATTTTCTACTTGTTTTCAATGTGTTGGAAACTGTAAAATG
ATACTGTAGAACCTGTCTCCTACTTTGAAAACTGAATGTCAGGGCTGAGTGAATCAAAGTGTCTAGACATATTTGCATAGAGGCCAAGGTATTCTATTCT
AATAACTGCTTACTCAACACTACCACCTTTTCCTTATACTGTATATGATTATGGCCTACAATGTTGTATTTGTTATTTATTAAATTGTGATTGTTTTATT
ATTGTTTATGCCAAATGTTAACTGCCAAGCTTGGAGTGACCTAAAGCATTTTTTAAAAGCATGGCTAGATTTACTTCAGTATAAATTATCTTATGAAAAC
CAAATTTTAAAAGCCACAGGTGTTGATTGTTATAAAATAACATGCTGCCATTCTTGATTGCTAGAGTTTTTGTTAGTACTTTGGATGCAATTAAAACTAT
GTGCTATCACATGTGAAAAGCTTAATAAATTCCATCTATCAGTAGTATAGGTCTCAATATTTATTATGAGACCAGTGGTCTGGAAACAGCTTGTTGTACC
GAATCAACTGGAGTCTATGCTTAAAAAAAAAAAATTTTTTTTTAACCATCCTTAAATTATTGCTTAATGGTATCATATTAACATATTCTAAATAAGGGCT
TTAAGGCACAGGCTGTTGAAGCATTTTCTCAGAGGAGTGGATCTGTAGAAGTCTGTCTTTCTATAGAAATATTGTGCTTACTCAAGTGTTAAATTATTTT
TTCTATGAACTAGTCTACTTCTTAAAATTCAAACATATTCTTTTGATCACATTGTTTCTTGAGCATCCTGCCCTGCTACTAACTTTTCAACAAGGCAAAA
TGGAGTAAAGTGGCAATTTCTTTAGATGAGTGAAATACCCTCAAGTCTCTTTTCTGCCCAAAAAGGGAAAAGTGATAGAAATGGGGGTGGCAAGTGGGGT
GAGTGGATGAAGGTGGGTATTGGGGGTGGCTGTGAAAGAAAATAATGGAGAATCACTTTTCTAGACATCTACCTATACTTAATCTAAGAAACAAAGTAAT
CTACTGTAAAGTACTCTGCCCCTTGAAAGAAGTATTAAAAAGAGTGAGGATGGATTTAGAAAAAAACATGAATTTAGAAATATTCAAAATGGTTTTTGTG
GCAGATTCAATATTATGAATTCACAGATATTTAAAGAATGAGAAACATAGTAATTAGTAGAAATGCCAGAAACAGTTCCTGGTTCCTCTTGTGTTTGACA
CTAAGAAAATAGCAAGAGTGTGAAATCTCAGATACTTATGAAATCTCACAGATGTAAGGACTCAAGTGTAGAAGAAAATATCCCCTTCTTACAAAAAGAA
ATGTCAATTTATGGAGTTTGTGGGAAATAGGGCAAGAATTCTTATGCTTATGAGAGCCAAGTAGTCAGTGGAAGAGAGTAGAGCTCAAAACTGGATTATC
ACCTTAGCAACTTAGAATAGTTTGAAATAGAAAAAAAGTATTTAATTTGGATCTGGATCTGTTAAGATATGCACAGTCTATTTTTTGTATAGTATTGGAA
AATAAAAATGCTATAATTTGGGTATGGGTTCTTTTGTATACATTACCTGCCCATTGAGGAAAGGGGCAAGTCCATTATGCAACTTCTCTCCAAACCCTTC
ATATTCTGGATATGATACTTAAAGAGCCATGAGCAGCTACATTCTGCCTATCAGAAGGCATTTATTAAATGACTGCTTGCTGAAGATGTGTCCAAAGAGA
TCCTACATTAAGGTCATTTGTCAGAATGATGTTTGTGTTTGTTTAGAGTTGGCTGACCTCCAACTCCTGGGGTCAAGGAATCCTACTGCCTTAGCTTCCC
AAATAGCTAGGACTATAGGCATGCACCCGGCCATGTGTTTTATTTATAGCTCTTAAAGCCCAGATGAAGAAATCACATTTTTGCCCATAGTGAAGAAACA
TTTGGCCATTGATTAGTCCTTATTTTCAGTGACTGTCCTGTTTTCATTAGATTAGAGAGACCCTGTGTGGGCCACAGTTAATATAAACCATTATCACTTT
TAAGTAAACCTGCACATCTTAGATTTCATAATTTCCTTATTGTTCTGACTCAAAATGAACTAAGAGCTTTTCACTTTTTGTTTGTAAGTTCTCAGAGAGT
CGGGTCTGCAAGTGCTTTTGCCTGCCAGGATTTTGTACTCAAATAAATGCTATTTGGCAACTAAAATTCTTGCCAGCTCTCATGTAATTTTGATGTTACT
GAGGTTGGTTGGTAGTTTATTTTATTAATTTTGTGGTTCTTCTATCATATAGAAAAAGCCAAATACAGTTTTGTTTGAATATTTGT
- TPD52.F12 (forward primer)
- TPD52.R11 (reverse primer)
- Single exon skipping
Frame 0
GEGASVRGWRP*CALGGKPREGSTAQPAPVSDWNQEQRTVSRSRPSRSAENRPSP*GRRRCCCHDQC
HRDPLGRGAGRAKKRTCKGRRRNPDSVSSVSSK
REASSRDQAETWNQFSTGTKTEHCQRVARRDSN
ICLQEDI*NLIPGWTEGLSCFFVCWLSHHQKAGR
CKYTFHSAFN*HACYEKLPNF*II*RKGRKLKV
*SRGNQACWW*FWRSLEFGCKC*CHHHGASSRK
DTGEPVRFLPLFCYPLPDAASEVQAHLVNMHCHE
FLPDVLLFSFTYSFDQIVCGLNKMKISSPLFLG
NTL*CTFMFLYLGNTIIKTLIVNGDIHYNDLRS
YRLS*LFSCFTKLLQIWNASLTFVFYNISFFSPL
*ISVYLILN*NCSLKYSESW*LKVWVYFLYLQG
KNY*LQKIFWNKHCFGIRYIFWLKTPD*SKQLC
IQFIIVL*VTICNQTSR*LESGTSYIII*HRL*Q
*PFQCIVYYTTYINLFFTRLKF*FLQNNILNQA
HCMFSRLNYEHCHQCSVQKPESLDLEAGKNDNI
NHIRGTIVVFT*SI*HYLK*AHQVI*LI*LENFL
Y*GVGDNS*GCNALIKINSSFSTCFQCVGNCKM
IL*NLSPTLKTECQG*VNQSV*TYLHRGQGILF
**LLTQHYHLFLILYMIMAYNVVFVIY*IVIVLL
LFMPNVNCQAWSDLKHFLKAWLDLLQYKLSYEN
QILKATGVDCYKITCCHS*LLEFLLVLWMQLKL
CAITCEKLNKFHLSVV*VSIFIMRPVVWKQLVVP
NQLESMLKKKKFFFNHP*IIA*WYHINIF*IRA
LRHRLLKHFLRGVDL*KSVFL*KYCAYSSVKLF
FL*TSLLLKIQTYSFDHIVS*ASCPATNFSTRQN
GVKWQFL*MSEIPSSLFSAQKGKSDRNGGGKWG
EWMKVGIGGGCERK*WRITFLDIYLYLI*ETK*
STVKYSAP*KKY*KE*GWI*KKT*I*KYSKWFLW
QIQYYEFTDI*RMRNIVISRNARNSSWFLLCLT
LRK*QECEISDTYEISQM*GLKCRRKYPLLTKR
NVNLWSLWEIGQEFLCL*EPSSQWKRVELKTGLS
P*QLRIV*NRKKVFNLDLDLLRYAQSIFCIVLE
NKNAIIWVWVLLYTLPAH*GKGQVHYATSLQTL
HILDMILKEP*AATFCLSEGIY*MTAC*RCVQRD
PTLRSFVRMMFVFV*SWLTSNSWGQGILLP*LP
K*LGL*ACTRPCVLFIALKAQMKKSHFCP**RN
IWPLISPYFQ*LSCFH*IRETLCGPQLI*TIITF
K*TCTS*IS*FPYCSDSK*TKSFSLFVCKFSES
RVCKCFCLPGFCTQINAIWQLKFLPALM*F*CY
*GWLVVYFINFVVLLSYRKSQIQFCLNIC
Frame 1
AKGLASGAGGRDALWVESRVKGARRSQLL*VTGTRNRGQ*VALVPPGLLRTDPVPEEGEDVAATIS
ATETLSEEEQEELRRELAKVEEEIQTLSQVLAAK
EKHLAEIKRKLGINSLQELKQNIAKGWQDVTAT
SAYKKTSETLSQAGQKASAAFSSVGSVITKKLE
DVNIRSIQHSISMPAMRNSPTFKSFEEKVENLKS
KVGGTKPAGGDFGEVLNSAANASATTTEPLPEK
TQESL*DSYLCSATHCQMLQARSKHILSTCIAM
NFYQMCFYLALHIPLTK*FVG*TK*KYLHLYSWE
TPFSVHLCSFI*ETPL*KHL**MGTFTIMI*EA
TDCHSCFPALQNCSRSGMPV*PLSSIIFPFFPL
FESLYI*FLTKIVLLNILNPGN*KFGCIFFTSKE
RTTSYKKYFGISIVLV*GTYFG*RHQTEVNSCA
SNLL*FCK*QYVIKLLGDLRVEPPISLFSTVCD
SNHFSVLFIIPLISTYFSPG*NFNFYKITF*IKH
TVCSVG*TMNTVINVQFKSLKV*I*KLVKMTIS
ITLGEPLLSSLNPFSTI*NKHTKLYD*YNLKIF
YTEGLVITLEDVMH**KSTHHFLLVFNVLETVK*
YCRTCLLL*KLNVRAE*IKVSRHICIEAKVFYS
NNCLLNTTTFSLYCI*LWPTMLYLLFIKL*LFY
YCLCQMLTAKLGVT*SIF*KHG*IYFSINYLMKT
KF*KPQVLIVIK*HAAILDC*SFC*YFGCN*NY
VLSHVKSLINSIYQ*YRSQYLL*DQWSGNSLLY
RINWSLCLKKKNFFLTILKLLLNGIILTYSK*GL
*GTGC*SIFSEEWICRSLSFYRNIVLTQVLNYF
FYELVYFLKFKHILLITLFLEHPALLLTFQQGK
ME*SGNFFR*VKYPQVSFLPKKGKVIEMGVASGV
SG*RWVLGVAVKENNGESLF*TSTYT*SKKQSN
LL*STLPLERSIKKSEDGFRKKHEFRNIQNGFC
GRFNIMNSQIFKE*ET**LVEMPETVPGSSCV*H
*ENSKSVKSQILMKSHRCKDSSVEENIPFLQKE
MSIYGVCGK*GKNSYAYESQVVSGRE*SSKLDY
HLSNLE*FEIEKKYLIWIWIC*DMHSLFFV*YWK
IKML*FGYGFFCIHYLPIEERGKSIMQLLSKPF
IFWI*YLKSHEQLHSAYQKAFIK*LLAEDVSKE
ILH*GHLSE*CLCLFRVG*PPTPGVKESYCLSFP
NS*DYRHAPGHVFYL*LLKPR*RNHIFAHSEET
FGH*LVLIFSDCPVFIRLERPCVGHS*YKPLSL
LSKPAHLRFHNFLIVLTQNELRAFHFLFVSSQRV
GSASAFACQDFVLK*MLFGN*NSCQLSCNFDVT
EVGW*FILLILWFFYHIEKAKYSFV*IF
Frame 2
RRG*RQGLAAVMRFGWKAA*REHGAASSCK*LEPGTEDSESLSSLQVC*EQTQSLRKEKMLLPRSV
PQRPSRKRSRKS*EENLQR*KKKSRLCLKC*QQ
KRSI*QRSSGNLESILYRN*NRTLPKGGKT*QQH
LLTRRHLKPYPRLDRRPQLLFRLLAQSSPKSWK
M*IYVPFSIQLACLL*ETPQLLNHLKKRSKT*S
LK*GEPSLLVVILEKS*IRLQMLVPPPRSLFQKR
HRRACEIPTFVLLPTARCCKRGPSTSCQHALP*
ISTRCAFI*LYIFL*PNSLWVKQNENIFTSILG
KHPLVYIYVPLFRKHHYKNTYSKWGHSL**SKKL
QIVIVVFLLYKIAPDLECQFDLCLL*YFLFFPS
LNLCIFDS*LKLFS*IF*ILVIKSLGVFSLPPR
KELLATKNILE*ALFWYKVHILVEDTRLK*TAVH
PIYYSFVSNNM*SNF*VT*EWNLLYHYLAPFVT
VTISVYCLLYHLYQLIFHQVKILISTK*HSESS
TLYVQ*VEL*TLSSMFSSKA*KFRSRSW*K*QYQ
SH*GNHCCLHLIHLALFKISTPSYMTNIT*KFF
ILRGW**LLRM*CINKNQLIIFYLFSMCWKL*N
DTVEPVSYFEN*MSGLSESKCLDIFA*RPRYSIL
ITAYSTLPPFPYTVYDYGLQCCICYLLNCDCFI
IVYAKC*LPSLE*PKAFFKSMARFTSV*IIL*K
PNFKSHRC*LL*NNMLPFLIARVFVSTLDAIKTM
CYHM*KA**IPSISSIGLNIYYETSGLETACCT
ESTGVYA*KKKIFF*PSLNYCLMVSY*HILNKG
FKAQAVEAFSQRSGSVEVCLSIEILCLLKC*IIF
SMN*STS*NSNIFF*SHCFLSILPCY*LFNKAK
WSKVAISLDE*NTLKSLFCPKREK**KWGWQVG
*VDEGGYWGWL*KKIMENHFSRHLPILNLRNKVI
YCKVLCPLKEVLKRVRMDLEKNMNLEIFKMVFV
ADSIL*IHRYLKNEKHSN**KCQKQFLVPLVFD
TKKIARV*NLRYL*NLTDVRTQV*KKISPSYKKK
CQFMEFVGNRARILMLMRAK*SVEESRAQNWII
TLAT*NSLK*KKSI*FGSGSVKICTVYFLYSIG
K*KCYNLGMGSFVYITCPLRKGASPLCNFSPNPS
YSGYDT*RAMSSYILPIRRHLLNDCLLKMCPKR
SYIKVICQNDVCVCLELADLQLLGSRNPTALAS
QIARTIGMHPAMCFIYSS*SPDEEITFLPIVKKH
LAID*SLFSVTVLFSLD*RDPVWATVNINHYHF
*VNLHILDFIISLLF*LKMN*ELFTFCL*VLRE
SGLQVLLPARILYSNKCYLATKILASSHVILMLL
RLVGSLFY*FCGSSII*KKPNTVLFEYL
Sequence TPD52.bAug05
CGGGCGGCGCCGCCGCGCCCGACGCCTCTGGGGGTGGGGACTTCGCGGGAGTCGCCGGCGGAGGCGAGGAGGAGCTCTGCGCGGCGCGGCGGGCGATCCGAGCCGGGACGGGCTGCAGGCGGGGGTGCTGCAGAGGACACGAGGCGGCGGGCTGGAGACATGGACCGCGGCGAGCAAGGTCTGCTGAGAACAGACCCAGT
CCCTGAGGAAGGAGAAGATGTTGCTGCCACGATCAGTGCCACAGAGACCCTCTCGGAAGAGGAGCAGGAAGAGCTAAGAAGAGAACTTGCAAAGGTAGAA
GAAGAAATCCAGACTCTGTCTCAAGTGTTAGCAGCAAAAGAGAAGCATCTAGCAGAGATCAAGCGGAAACTTGGAATCAATTCTCTACAGGAACTAAAAC
AGAACATTGCCAAAGGGTGGCAAGACGTGACAGCAACATCTGCTTACAAGAAGACATCTGAAACCTTATCCCAGGCTGGACAGAAGGCCTCAGCTGCTTT
TTCGTCTGTTGGCTCAGTCATCACCAAAAAGCTGGAAGATGTAAAATTGCAAGCCTTTTCACATTCCTTTAGTATACGTTCCATTCAGCATTCAATTAGC
ATGCCTGCTATGAGAAACTCCCCAACTTTTAAATCATTTGAAGAAAAGGTCGAAAACTTAAAGTCTAAAGTAGGGGGAACCAAGCCTGCTGGTGGTGATT
TTGGAGAAGTCTTGAATTCGGCTGCAAATGCTAGTGCCACCACCACGGAGCCTCTTCCAGAAAAGACACAGGAGAGCCTGTGAGATTCCTACCTTTGTTC
TGCTACCCACTGCCAGATGCTGCAAGCGAGGTCCAAGCACATCTTGTCAACATGCATTGCCATGAATTTCTACCAGATGTGCTTTTATTTAGCTTTACAT
ATTCCTTTGACCAAATAGTTTGTGGGTTAAACAAAATGAAAATATCTTCACCTCTATTCTTGGGAAACACCCTTTAGTGTACATTTATGTTCCTTTATTT
AGGAAACACCATTATAAAAACACTTATAGTAAATGGGGACATTCACTATAATGATCTAAGAAGCTACAGATTGTCATAGTTGTTTTCCTGCTTTACAAAA
TTGCTCCAGATCTGGAATGCCAGTTTGACCTTTGTCTTCTATAATATTTCCTTTTTTTCCCCTCTTTGAATCTCTGTATATTTGATTCTTAACTAAAATT
GTTCTCTTAAATATTCTGAATCCTGGTAATTAAAAGTTTGGGTGTATTTTCTTTACCTCCAAGGAAAGAACTACTAGCTACAAAAAATATTTTGGAATAA
GCATTGTTTTGGTATAAGGTACATATTTTGGTTGAAGACACCAGACTGAAGTAAACAGCTGTGCATCCAATTTATTATAGTTTTGTAAGTAACAATATGT
AATCAAACTTCTAGGTGACTTGAGAGTGGAACCTCCTATATCATTATTTAGCACCGTTTGTGACAGTAACCATTTCAGTGTATTGTTTATTATACCACTT
ATATCAACTTATTTTTCACCAGGTTAAAATTTTAATTTCTACAAAATAACATTCTGAATCAAGCACACTGTATGTTCAGTAGGTTGAACTATGAACACTG
TCATCAATGTTCAGTTCAAAAGCCTGAAAGTTTAGATCTAGAAGCTGGTAAAAATGACAATATCAATCACATTAGGGGAACCATTGTTGTCTTCACTTAA
TCCATTTAGCACTATTTAAAATAAGCACACCAAGTTATATGACTAATATAACTTGAAAATTTTTTATACTGAGGGGTTGGTGATAACTCTTGAGGATGTA
ATGCATTAATAAAAATCAACTCATCATTTTCTACTTGTTTTCAATGTGTTGGAAACTGTAAAATGATACTGTAGAACCTGTCTCCTACTTTGAAAACTGA
ATGTCAGGGCTGAGTGAATCAAAGTGTCTAGACATATTTGCATAGAGGCCAAGGTATTCTATTCTAATAACTGCTTACTCAACACTACCACCTTTTCCTT
ATACTGTATATGATTATGGCCTACAATGTTGTATTTGTTATTTATTAAATTGTGATTGTTTTATTATTGTTTATGCCAAATGTTAACTGCCAAGCTTGGA
GTGACCTAAAGCATTTTTTAAAAGCATGGCTAGATTTACTTCAGTATAAATTATCTTATGAAAACCAAATTTTAAAAGCCACAGGTGTTGATTGTTATAA
AATAACATGCTGCCATTCTTGATTGCTAGAGTTTTTGTTAGTACTTTGGATGCAATTAAAACTATGTGCTATCACATGTGAAAAGCTTAATAAATTCCAT
CTATCAGTAGTATAGGTCTCAATATTTATTATGAGACCAGTGGTCTGGAAACAGCTTGTTGTACCGAATCAACTGGAGTCTATGCTTAAAAAAAAAAAAT
TTTTTTTTAACCATCCTTAAATTATTGCTTAATGGTATCATATTAACATATTCTAAATAAGGGCTTTAAGGCACAGGCTGTTGAAGCATTTTCTCAGAGG
AGTGGATCTGTAGAAGTCTGTCTTTCTATAGAAATATTGTGCTTACTCAAGTGTTAAATTATTTTTTCTATGAACTAGTCTACTTCTTAAAATTCAAACA
TATTCTTTTGATCACATTGTTTCTTGAGCATCCTGCCCTGCTACTAACTTTTCAACAAGGCAAAATGGAGTAAAGTGGCAATTTCTTTAGATGAGTGAAA
TACCCTCAAGTCTCTTTTCTGCCCAAAAAGGGAAAAGTGATAGAAATGGGGGTGGCAAGTGGGGTGAGTGGATGAAGGTGGGTATTGGGGGTGGCTGTGA
AAGAAAATAATGGAGAATCACTTTTCTAGACATCTACCTATACTTAATCTAAGAAACAAAGTAATCTACTGTAAAGTACTCTGCCCCTTGAAAGAAGTAT
TAAAAAGAGTGAGGATGGATTTAGAAAAAAACATGAATTTAGAAATATTCAAAATGGTTTTTGTGGCAGATTCAATATTATGAATTCACAGATATTTAAA
GAATGAGAAACATAGTAATTAGTAGAAATGCCAGAAACAGTTCCTGGTTCCTCTTGTGTTTGACACTAAGAAAATAGCAAGAGTGTGAAATCTCAGATAC
TTATGAAATCTCACAGATGTAAGGACTCAAGTGTAGAAGAAAATATCCCCTTCTTACAAAAAGAAATGTCAATTTATGGAGTTTGTGGGAAATAGGGCAA
GAATTCTTATGCTTATGAGAGCCAAGTAGTCAGTGGAAGAGAGTAGAGCTCAAAACTGGATTATCACCTTAGCAACTTAGAATAGTTTGAAATAGAAAAA
AAGTATTTAATTTGGATCTGGATCTGTTAAGATATGCACAGTCTATTTTTTGTATAGTATTGGAAAATAAAAATGCTATAATTTGGGTATGGGTTCTTTT
GTATACATTACCTGCCCATTGAGGAAAGGGGCAAGTCCATTATGCAACTTCTCTCCAAACCCTTCATATTCTGGATATGATACTTAAAGAGCCATGAGCA
GCTACATTCTGCCTATCAGAAGGCATTTATTAAATGACTGCTTGCTGAAGATGTGTCCAAAGAGATCCTACATTAAGGTCATTTGTCAGAATGATGTTTG
TGTTTGTTTAGAGTTGGCTGACCTCCAACTCCTGGGGTCAAGGAATCCTACTGCCTTAGCTTCCCAAATAGCTAGGACTATAGGCATGCACCCGGCCATG
TGTTTTATTTATAGCTCTTAAAGCCCAGATGAAGAAATCACATTTTTGCCCATAGTGAAGAAACATTTGGCCATTGATTAGTCCTTATTTTCAGTGACTG
TCCTGTTTTCATTAGATTAGAGAGACCCTGTGTGGGCCACAGTTAATATAAACCATTATCACTTTTAAGTAAACCTGCACATCTTAGATTTCATAATTTC
CTTATTGTTCTGACTCAAAATGAACTAAGAGCTTTTCACTTTTTGTTTGTAAGTTCTCAGAGAGTCGGGTCTGCAAGTGCTTTTGCCTGCCAGGATTTTG
TACTCAAATAAATGCTATTTGGCAACTAAAATTCTTGCCAGCTCTCATGTAATTTTGATGTTACTGAGGTTGGTTGGTAGTTTATTTTATTAATTTTGTG
GTTCTTCTATCATATAGAAAAAGCCAAATACAGTTTTGTTTGAATATTTGT
- TPD52.F12 (forward primer)
- TPD52.R11 (reverse primer)
- Single exon skipping
Frame 0
RAAPPRPTPLGVGTSRESPAEARRSSARRGGRSEPGRAAGGGAAEDTRRRAGDMDRGEQGLLRTDPV
PEEGEDVAATISATETLSEEEQEELRRELAKVE
EEIQTLSQVLAAKEKHLAEIKRKLGINSLQELK
QNIAKGWQDVTATSAYKKTSETLSQAGQKASAAF
SSVGSVITKKLEDVKLQAFSHSFSIRSIQHSIS
MPAMRNSPTFKSFEEKVENLKSKVGGTKPAGGD
FGEVLNSAANASATTTEPLPEKTQESL*DSYLCS
ATHCQMLQARSKHILSTCIAMNFYQMCFYLALH
IPLTK*FVG*TK*KYLHLYSWETPFSVHLCSFI
*ETPL*KHL**MGTFTIMI*EATDCHSCFPALQN
CSRSGMPV*PLSSIIFPFFPLFESLYI*FLTKI
VLLNILNPGN*KFGCIFFTSKERTTSYKKYFGI
SIVLV*GTYFG*RHQTEVNSCASNLL*FCK*QYV
IKLLGDLRVEPPISLFSTVCDSNHFSVLFIIPL
ISTYFSPG*NFNFYKITF*IKHTVCSVG*TMNT
VINVQFKSLKV*I*KLVKMTISITLGEPLLSSLN
PFSTI*NKHTKLYD*YNLKIFYTEGLVITLEDV
MH**KSTHHFLLVFNVLETVK*YCRTCLLL*KL
NVRAE*IKVSRHICIEAKVFYSNNCLLNTTTFSL
YCI*LWPTMLYLLFIKL*LFYYCLCQMLTAKLG
VT*SIF*KHG*IYFSINYLMKTKF*KPQVLIVI
K*HAAILDC*SFC*YFGCN*NYVLSHVKSLINSI
YQ*YRSQYLL*DQWSGNSLLYRINWSLCLKKKN
FFLTILKLLLNGIILTYSK*GL*GTGC*SIFSE
EWICRSLSFYRNIVLTQVLNYFFYELVYFLKFKH
ILLITLFLEHPALLLTFQQGKME*SGNFFR*VK
YPQVSFLPKKGKVIEMGVASGVSG*RWVLGVAV
KENNGESLF*TSTYT*SKKQSNLL*STLPLERSI
KKSEDGFRKKHEFRNIQNGFCGRFNIMNSQIFK
E*ET**LVEMPETVPGSSCV*H*ENSKSVKSQI
LMKSHRCKDSSVEENIPFLQKEMSIYGVCGK*GK
NSYAYESQVVSGRE*SSKLDYHLSNLE*FEIEK
KYLIWIWIC*DMHSLFFV*YWKIKML*FGYGFF
CIHYLPIEERGKSIMQLLSKPFIFWI*YLKSHEQ
LHSAYQKAFIK*LLAEDVSKEILH*GHLSE*CL
CLFRVG*PPTPGVKESYCLSFPNS*DYRHAPGH
VFYL*LLKPR*RNHIFAHSEETFGH*LVLIFSDC
PVFIRLERPCVGHS*YKPLSLLSKPAHLRFHNF
LIVLTQNELRAFHFLFVSSQRVGSASAFACQDF
VLK*MLFGN*NSCQLSCNFDVTEVGW*FILLILW
FFYHIEKAKYSFV*IF
Frame 1
GRRRRARRLWGWGLRGSRRRRRGGALRGAAGDPSRDGLQAGVLQRTRGGGLETWTAASKVC*EQTQ
SLRKEKMLLPRSVPQRPSRKRSRKS*EENLQR*K
KKSRLCLKC*QQKRSI*QRSSGNLESILYRN*N
RTLPKGGKT*QQHLLTRRHLKPYPRLDRRPQLL
FRLLAQSSPKSWKM*NCKPFHIPLVYVPFSIQLA
CLL*ETPQLLNHLKKRSKT*SLK*GEPSLLVVI
LEKS*IRLQMLVPPPRSLFQKRHRRACEIPTFV
LLPTARCCKRGPSTSCQHALP*ISTRCAFI*LYI
FL*PNSLWVKQNENIFTSILGKHPLVYIYVPLF
RKHHYKNTYSKWGHSL**SKKLQIVIVVFLLYK
IAPDLECQFDLCLL*YFLFFPSLNLCIFDS*LKL
FS*IF*ILVIKSLGVFSLPPRKELLATKNILE*
ALFWYKVHILVEDTRLK*TAVHPIYYSFVSNNM
*SNF*VT*EWNLLYHYLAPFVTVTISVYCLLYHL
YQLIFHQVKILISTK*HSESSTLYVQ*VEL*TL
SSMFSSKA*KFRSRSW*K*QYQSH*GNHCCLHL
IHLALFKISTPSYMTNIT*KFFILRGW**LLRM*
CINKNQLIIFYLFSMCWKL*NDTVEPVSYFEN*
MSGLSESKCLDIFA*RPRYSILITAYSTLPPFP
YTVYDYGLQCCICYLLNCDCFIIVYAKC*LPSLE
*PKAFFKSMARFTSV*IIL*KPNFKSHRC*LL*
NNMLPFLIARVFVSTLDAIKTMCYHM*KA**IP
SISSIGLNIYYETSGLETACCTESTGVYA*KKKI
FF*PSLNYCLMVSY*HILNKGFKAQAVEAFSQR
SGSVEVCLSIEILCLLKC*IIFSMN*STS*NSN
IFF*SHCFLSILPCY*LFNKAKWSKVAISLDE*N
TLKSLFCPKREK**KWGWQVG*VDEGGYWGWL*
KKIMENHFSRHLPILNLRNKVIYCKVLCPLKEV
LKRVRMDLEKNMNLEIFKMVFVADSIL*IHRYLK
NEKHSN**KCQKQFLVPLVFDTKKIARV*NLRY
L*NLTDVRTQV*KKISPSYKKKCQFMEFVGNRA
RILMLMRAK*SVEESRAQNWIITLAT*NSLK*KK
SI*FGSGSVKICTVYFLYSIGK*KCYNLGMGSF
VYITCPLRKGASPLCNFSPNPSYSGYDT*RAMS
SYILPIRRHLLNDCLLKMCPKRSYIKVICQNDVC
VCLELADLQLLGSRNPTALASQIARTIGMHPAM
CFIYSS*SPDEEITFLPIVKKHLAID*SLFSVT
VLFSLD*RDPVWATVNINHYHF*VNLHILDFIIS
LLF*LKMN*ELFTFCL*VLRESGLQVLLPARIL
YSNKCYLATKILASSHVILMLLRLVGSLFY*FC
GSSII*KKPNTVLFEYL
Frame 2
GGAAAPDASGGGDFAGVAGGGEEELCAARRAIRAGTGCRRGCCRGHEAAGWRHGPRRARSAENRPS
P*GRRRCCCHDQCHRDPLGRGAGRAKKRTCKGR
RRNPDSVSSVSSKREASSRDQAETWNQFSTGTKT
EHCQRVARRDSNICLQEDI*NLIPGWTEGLSCF
FVCWLSHHQKAGRCKIASLFTFL*YTFHSAFN*
HACYEKLPNF*II*RKGRKLKV*SRGNQACWW*F
WRSLEFGCKC*CHHHGASSRKDTGEPVRFLPLF
CYPLPDAASEVQAHLVNMHCHEFLPDVLLFSFT
YSFDQIVCGLNKMKISSPLFLGNTL*CTFMFLYL
GNTIIKTLIVNGDIHYNDLRSYRLS*LFSCFTK
LLQIWNASLTFVFYNISFFSPL*ISVYLILN*N
CSLKYSESW*LKVWVYFLYLQGKNY*LQKIFWNK
HCFGIRYIFWLKTPD*SKQLCIQFIIVL*VTIC
NQTSR*LESGTSYIII*HRL*Q*PFQCIVYYTT
YINLFFTRLKF*FLQNNILNQAHCMFSRLNYEHC
HQCSVQKPESLDLEAGKNDNINHIRGTIVVFT*
SI*HYLK*AHQVI*LI*LENFLY*GVGDNS*GC
NALIKINSSFSTCFQCVGNCKMIL*NLSPTLKTE
CQG*VNQSV*TYLHRGQGILF**LLTQHYHLFL
ILYMIMAYNVVFVIY*IVIVLLLFMPNVNCQAW
SDLKHFLKAWLDLLQYKLSYENQILKATGVDCYK
ITCCHS*LLEFLLVLWMQLKLCAITCEKLNKFH
LSVV*VSIFIMRPVVWKQLVVPNQLESMLKKKK
FFFNHP*IIA*WYHINIF*IRALRHRLLKHFLRG
VDL*KSVFL*KYCAYSSVKLFFL*TSLLLKIQT
YSFDHIVS*ASCPATNFSTRQNGVKWQFL*MSE
IPSSLFSAQKGKSDRNGGGKWGEWMKVGIGGGCE
RK*WRITFLDIYLYLI*ETK*STVKYSAP*KKY
*KE*GWI*KKT*I*KYSKWFLWQIQYYEFTDI*
RMRNIVISRNARNSSWFLLCLTLRK*QECEISDT
YEISQM*GLKCRRKYPLLTKRNVNLWSLWEIGQ
EFLCL*EPSSQWKRVELKTGLSP*QLRIV*NRK
KVFNLDLDLLRYAQSIFCIVLENKNAIIWVWVLL
YTLPAH*GKGQVHYATSLQTLHILDMILKEP*A
ATFCLSEGIY*MTAC*RCVQRDPTLRSFVRMMF
VFV*SWLTSNSWGQGILLP*LPK*LGL*ACTRPC
VLFIALKAQMKKSHFCP**RNIWPLISPYFQ*L
SCFH*IRETLCGPQLI*TIITFK*TCTS*IS*F
PYCSDSK*TKSFSLFVCKFSESRVCKCFCLPGFC
TQINAIWQLKFLPALM*F*CY*GWLVVYFINFV
VLLSYRKSQIQFCLNIC
Sequence TPD52.aAug05
AGTGTCTGATGTTTGCCTGAACTGTTTGTACCTCTGGGCCATATTGCAGAACCCTGCCCTTCTTTGTTGACTGAGGAAAGCTCGCTCCCTGCCCAGGTTTTTCATTGTTGATCGAAATTAACACCAGGTGGTGAATAGAGCCCCTCCTAAGGTTGCTCAGGATAAATCATTTATTAAATAGGTCTGCTTATCAGGAGGGG
CGTGAAGGCTCCCAAAAGGAAATGCTGGCACCTGGGCCCAGAAGCCAGGGCCTCTAACTCCTGGGGTTGATTTCTTCAGTGAAGTTGCACCCTACAAAGG
GAATATGGCCAAAGCGGCACTCAACTGAAGGCTGATATCAGGCGATTAGACAGCCATGCATTCTGCGTTTGTCTGGAATGGATTGTAGAGAGATGGACTT
ATATGAGGACTACCAGTCCCCGTTTGATTTTGATGCAGGAGTGAACAAAAGCTATCTCTACTTGTCTCCTAGTGGAAATTCATCTCCACCCGGATCACCT
ACTCTTCAGAAATTTGGTCTGCTGAGAACAGACCCAGTCCCTGAGGAAGGAGAAGATGTTGCTGCCACGATCAGTGCCACAGAGACCCTCTCGGAAGAGG
AGCAGGAAGAGCTAAGAAGAGAACTTGCAAAGGTAGAAGAAGAAATCCAGACTCTGTCTCAAGTGTTAGCAGCAAAAGAGAAGCATCTAGCAGAGATCAA
GCGGAAACTTGGAATCAATTCTCTACAGGAACTAAAACAGAACATTGCCAAAGGGTGGCAAGACGTGACAGCAACATCTGCTTACAAGAAGACATCTGAA
ACCTTATCCCAGGCTGGACAGAAGGCCTCAGCTGCTTTTTCGTCTGTTGGCTCAGTCATCACCAAAAAGCTGGAAGATGTAAAATTGCAAGCCTTTTCAC
ATTCCTTTAGTATACGTTCCATTCAGCATTCAATTAGCATGCCTGCTATGAGAAACTCCCCAACTTTTAAATCATTTGAAGAAAAGGTCGAAAACTTAAA
GTCTAAAGTAGGGGGAACCAAGCCTGCTGGTGGTGATTTTGGAGAAGTCTTGAATTCGGCTGCAAATGCTAGTGCCACCACCACGGAGCCTCTTCCAGAA
AAGACACAGGAGAGCCTGTGAGATTCCTACCTTTGTTCTGCTACCCACTGCCAGATGCTGCAAGCGAGGTCCAAGCACATCTTGTCAACATGCATTGCCA
TGAATTTCTACCAGATGTGCTTTTATTTAGCTTTACATATTCCTTTGACCAAATAGTTTGTGGGTTAAACAAAATGAAAATATCTTCACCTCTATTCTTG
GGAAACACCCTTTAGTGTACATTTATGTTCCTTTATTTAGGAAACACCATTATAAAAACACTTATAGTAAATGGGGACATTCACTATAATGATCTAAGAA
GCTACAGATTGTCATAGTTGTTTTCCTGCTTTACAAAATTGCTCCAGATCTGGAATGCCAGTTTGACCTTTGTCTTCTATAATATTTCCTTTTTTTCCCC
TCTTTGAATCTCTGTATATTTGATTCTTAACTAAAATTGTTCTCTTAAATATTCTGAATCCTGGTAATTAAAAGTTTGGGTGTATTTTCTTTACCTCCAA
GGAAAGAACTACTAGCTACAAAAAATATTTTGGAATAAGCATTGTTTTGGTATAAGGTACATATTTTGGTTGAAGACACCAGACTGAAGTAAACAGCTGT
GCATCCAATTTATTATAGTTTTGTAAGTAACAATATGTAATCAAACTTCTAGGTGACTTGAGAGTGGAACCTCCTATATCATTATTTAGCACCGTTTGTG
ACAGTAACCATTTCAGTGTATTGTTTATTATACCACTTATATCAACTTATTTTTCACCAGGTTAAAATTTTAATTTCTACAAAATAACATTCTGAATCAA
GCACACTGTATGTTCAGTAGGTTGAACTATGAACACTGTCATCAATGTTCAGTTCAAAAGCCTGAAAGTTTAGATCTAGAAGCTGGTAAAAATGACAATA
TCAATCACATTAGGGGAACCATTGTTGTCTTCACTTAATCCATTTAGCACTATTTAAAATAAGCACACCAAGTTATATGACTAATATAACTTGAAAATTT
TTTATACTGAGGGGTTGGTGATAACTCTTGAGGATGTAATGCATTAATAAAAATCAACTCATCATTTTCTACTTGTTTTCAATGTGTTGGAAACTGTAAA
ATGATACTGTAGAACCTGTCTCCTACTTTGAAAACTGAATGTCAGGGCTGAGTGAATCAAAGTGTCTAGACATATTTGCATAGAGGCCAAGGTATTCTAT
TCTAATAACTGCTTACTCAACACTACCACCTTTTCCTTATACTGTATATGATTATGGCCTACAATGTTGTATTTGTTATTTATTAAATTGTGATTGTTTT
ATTATTGTTTATGCCAAATGTTAACTGCCAAGCTTGGAGTGACCTAAAGCATTTTTTAAAAGCATGGCTAGATTTACTTCAGTATAAATTATCTTATGAA
AACCAAATTTTAAAAGCCACAGGTGTTGATTGTTATAAAATAACATGCTGCCATTCTTGATTGCTAGAGTTTTTGTTAGTACTTTGGATGCAATTAAAAC
TATGTGCTATCACATGTGAAAAGCTTAATAAATTCCATCTATCAGTAGTATAGGTCTCAATATTTATTATGAGACCAGTGGTCTGGAAACAGCTTGTTGT
ACCGAATCAACTGGAGTCTATGCTTAAAAAAAAAAAATTTTTTTTTAACCATCCTTAAATTATTGCTTAATGGTATCATATTAACATATTCTAAATAAGG
GCTTTAAGGCACAGGCTGTTGAAGCATTTTCTCAGAGGAGTGGATCTGTAGAAGTCTGTCTTTCTATAGAAATATTGTGCTTACTCAAGTGTTAAATTAT
TTTTTCTATGAACTAGTCTACTTCTTAAAATTCAAACATATTCTTTTGATCACATTGTTTCTTGAGCATCCTGCCCTGCTACTAACTTTTCAACAAGGCA
AAATGGAGTAAAGTGGCAATTTCTTTAGATGAGTGAAATACCCTCAAGTCTCTTTTCTGCCCAAAAAGGGAAAAGTGATAGAAATGGGGGTGGCAAGTGG
GGTGAGTGGATGAAGGTGGGTATTGGGGGTGGCTGTGAAAGAAAATAATGGAGAATCACTTTTCTAGACATCTACCTATACTTAATCTAAGAAACAAAGT
AATCTACTGTAAAGTACTCTGCCCCTTGAAAGAAGTATTAAAAAGAGTGAGGATGGATTTAGAAAAAAACATGAATTTAGAAATATTCAAAATGGTTTTT
GTGGCAGATTCAATATTATGAATTCACAGATATTTAAAGAATGAGAAACATAGTAATTAGTAGAAATGCCAGAAACAGTTCCTGGTTCCTCTTGTGTTTG
ACACTAAGAAAATAGCAAGAGTGTGAAATCTCAGATACTTATGAAATCTCACAGATGTAAGGACTCAAGTGTAGAAGAAAATATCCCCTTCTTACAAAAA
GAAATGTCAATTTATGGAGTTTGTGGGAAATAGGGCAAGAATTCTTATGCTTATGAGAGCCAAGTAGTCAGTGGAAGAGAGTAGAGCTCAAAACTGGATT
ATCACCTTAGCAACTTAGAATAGTTTGAAATAGAAAAAAAGTATTTAATTTGGATCTGGATCTGTTAAGATATGCACAGTCTATTTTTTGTATAGTATTG
GAAAATAAAAATGCTATAATTTGGGTATGGGTTCTTTTGTATACATTACCTGCCCATTGAGGAAAGGGGCAAGTCCATTATGCAACTTCTCTCCAAACCC
TTCATATTCTGGATATGATACTTAAAGAGCCATGAGCAGCTACATTCTGCCTATCAGAAGGCATTTATTAAATGACTGCTTGCTGAAGATGTGTCCAAAG
AGATCCTACATTAAGGTCATTTGTCAGAATGATGTTTGTGTTTGTTTAGAGTTGGCTGACCTCCAACTCCTGGGGTCAAGGAATCCTACTGCCTTAGCTT
CCCAAATAGCTAGGACTATAGGCATGCACCCGGCCATGTGTTTTATTTATAGCTCTTAAAGCCCAGATGAAGAAATCACATTTTTGCCCATAGTGAAGAA
ACATTTGGCCATTGATTAGTCCTTATTTTCAGTGACTGTCCTGTTTTCATTAGATTAGAGAGACCCTGTGTGGGCCACAGTTAATATAAACCATTATCAC
TTTTAAGTAAACCTGCACATCTTAGATTTCATAATTTCCTTATTGTTCTGACTCAAAATGAACTAAGAGCTTTTCACTTTTTGTTTGTAAGTTCTCAGAG
AGTCGGGTCTGCAAGTGCTTTTGCCTGCCAGGATTTTGTACTCAAATAAATGCTATTTGGCAACTAAAATTCTTGCCAGCTCTCATGTAATTTTGATGTT
ACTGAGGTTGGTTGGTAGTTTATTTTATTAATTTTGTGGTTCTTCTATCATATAGAAAAAGCCAAATACAGTTTTGTTTGAATATTTGT
- TPD52.F12 (forward primer)
- TPD52.R11 (reverse primer)
- Single exon skipping
Frame 0
SV*CLPELFVPLGHIAEPCPSLLTEESSLPAQVFHC*SKLTPGGE*SPS*GCSG*IIY*IGLLIRRG
VKAPKRKCWHLGPEARASNSWG*FLQ*SCTLQR
EYGQSGTQLKADIRRLDSHAFCVCLEWIVERWT
YMRTTSPRLILMQE*TKAISTCLLVEIHLHPDHL
LFRNLVC*EQTQSLRKEKMLLPRSVPQRPSRKR
SRKS*EENLQR*KKKSRLCLKC*QQKRSI*QRS
SGNLESILYRN*NRTLPKGGKT*QQHLLTRRHLK
PYPRLDRRPQLLFRLLAQSSPKSWKM*NCKPFH
IPLVYVPFSIQLACLL*ETPQLLNHLKKRSKT*
SLK*GEPSLLVVILEKS*IRLQMLVPPPRSLFQK
RHRRACEIPTFVLLPTARCCKRGPSTSCQHALP
*ISTRCAFI*LYIFL*PNSLWVKQNENIFTSIL
GKHPLVYIYVPLFRKHHYKNTYSKWGHSL**SKK
LQIVIVVFLLYKIAPDLECQFDLCLL*YFLFFP
SLNLCIFDS*LKLFS*IF*ILVIKSLGVFSLPP
RKELLATKNILE*ALFWYKVHILVEDTRLK*TAV
HPIYYSFVSNNM*SNF*VT*EWNLLYHYLAPFV
TVTISVYCLLYHLYQLIFHQVKILISTK*HSES
STLYVQ*VEL*TLSSMFSSKA*KFRSRSW*K*QY
QSH*GNHCCLHLIHLALFKISTPSYMTNIT*KF
FILRGW**LLRM*CINKNQLIIFYLFSMCWKL*
NDTVEPVSYFEN*MSGLSESKCLDIFA*RPRYSI
LITAYSTLPPFPYTVYDYGLQCCICYLLNCDCF
IIVYAKC*LPSLE*PKAFFKSMARFTSV*IIL*
KPNFKSHRC*LL*NNMLPFLIARVFVSTLDAIKT
MCYHM*KA**IPSISSIGLNIYYETSGLETACC
TESTGVYA*KKKIFF*PSLNYCLMVSY*HILNK
GFKAQAVEAFSQRSGSVEVCLSIEILCLLKC*II
FSMN*STS*NSNIFF*SHCFLSILPCY*LFNKA
KWSKVAISLDE*NTLKSLFCPKREK**KWGWQV
G*VDEGGYWGWL*KKIMENHFSRHLPILNLRNKV
IYCKVLCPLKEVLKRVRMDLEKNMNLEIFKMVF
VADSIL*IHRYLKNEKHSN**KCQKQFLVPLVF
DTKKIARV*NLRYL*NLTDVRTQV*KKISPSYKK
KCQFMEFVGNRARILMLMRAK*SVEESRAQNWI
ITLAT*NSLK*KKSI*FGSGSVKICTVYFLYSI
GK*KCYNLGMGSFVYITCPLRKGASPLCNFSPNP
SYSGYDT*RAMSSYILPIRRHLLNDCLLKMCPK
RSYIKVICQNDVCVCLELADLQLLGSRNPTALA
SQIARTIGMHPAMCFIYSS*SPDEEITFLPIVKK
HLAID*SLFSVTVLFSLD*RDPVWATVNINHYH
F*VNLHILDFIISLLF*LKMN*ELFTFCL*VLR
ESGLQVLLPARILYSNKCYLATKILASSHVILML
LRLVGSLFY*FCGSSII*KKPNTVLFEYL
Frame 1
VSDVCLNCLYLWAILQNPALLC*LRKARSLPRFFIVDRN*HQVVNRAPPKVAQDKSFIK*VCLSGG
A*RLPKGNAGTWAQKPGPLTPGVDFFSEVAPYKG
NMAKAALN*RLISGD*TAMHSAFVWNGL*RDGL
I*GLPVPV*F*CRSEQKLSLLVS*WKFISTRIT
YSSEIWSAENRPSP*GRRRCCCHDQCHRDPLGRG
AGRAKKRTCKGRRRNPDSVSSVSSKREASSRDQ
AETWNQFSTGTKTEHCQRVARRDSNICLQEDI*
NLIPGWTEGLSCFFVCWLSHHQKAGRCKIASLFT
FL*YTFHSAFN*HACYEKLPNF*II*RKGRKLK
V*SRGNQACWW*FWRSLEFGCKC*CHHHGASSR
KDTGEPVRFLPLFCYPLPDAASEVQAHLVNMHCH
EFLPDVLLFSFTYSFDQIVCGLNKMKISSPLFL
GNTL*CTFMFLYLGNTIIKTLIVNGDIHYNDLR
SYRLS*LFSCFTKLLQIWNASLTFVFYNISFFSP
L*ISVYLILN*NCSLKYSESW*LKVWVYFLYLQ
GKNY*LQKIFWNKHCFGIRYIFWLKTPD*SKQL
CIQFIIVL*VTICNQTSR*LESGTSYIII*HRL*
Q*PFQCIVYYTTYINLFFTRLKF*FLQNNILNQ
AHCMFSRLNYEHCHQCSVQKPESLDLEAGKNDN
INHIRGTIVVFT*SI*HYLK*AHQVI*LI*LENF
LY*GVGDNS*GCNALIKINSSFSTCFQCVGNCK
MIL*NLSPTLKTECQG*VNQSV*TYLHRGQGIL
F**LLTQHYHLFLILYMIMAYNVVFVIY*IVIVL
LLFMPNVNCQAWSDLKHFLKAWLDLLQYKLSYE
NQILKATGVDCYKITCCHS*LLEFLLVLWMQLK
LCAITCEKLNKFHLSVV*VSIFIMRPVVWKQLVV
PNQLESMLKKKKFFFNHP*IIA*WYHINIF*IR
ALRHRLLKHFLRGVDL*KSVFL*KYCAYSSVKL
FFL*TSLLLKIQTYSFDHIVS*ASCPATNFSTRQ
NGVKWQFL*MSEIPSSLFSAQKGKSDRNGGGKW
GEWMKVGIGGGCERK*WRITFLDIYLYLI*ETK
*STVKYSAP*KKY*KE*GWI*KKT*I*KYSKWFL
WQIQYYEFTDI*RMRNIVISRNARNSSWFLLCL
TLRK*QECEISDTYEISQM*GLKCRRKYPLLTK
RNVNLWSLWEIGQEFLCL*EPSSQWKRVELKTGL
SP*QLRIV*NRKKVFNLDLDLLRYAQSIFCIVL
ENKNAIIWVWVLLYTLPAH*GKGQVHYATSLQT
LHILDMILKEP*AATFCLSEGIY*MTAC*RCVQR
DPTLRSFVRMMFVFV*SWLTSNSWGQGILLP*L
PK*LGL*ACTRPCVLFIALKAQMKKSHFCP**R
NIWPLISPYFQ*LSCFH*IRETLCGPQLI*TIIT
FK*TCTS*IS*FPYCSDSK*TKSFSLFVCKFSE
SRVCKCFCLPGFCTQINAIWQLKFLPALM*F*C
Y*GWLVVYFINFVVLLSYRKSQIQFCLNIC
Frame 2
CLMFA*TVCTSGPYCRTLPFFVD*GKLAPCPGFSLLIEINTRW*IEPLLRLLRINHLLNRSAYQEG
REGSQKEMLAPGPRSQGL*LLGLISSVKLHPTK
GIWPKRHSTEG*YQAIRQPCILRLSGMDCREMDL
YEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSP
TLQKFGLLRTDPVPEEGEDVAATISATETLSEE
EQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIK
RKLGINSLQELKQNIAKGWQDVTATSAYKKTSE
TLSQAGQKASAAFSSVGSVITKKLEDVKLQAFS
HSFSIRSIQHSISMPAMRNSPTFKSFEEKVENLK
SKVGGTKPAGGDFGEVLNSAANASATTTEPLPE
KTQESL*DSYLCSATHCQMLQARSKHILSTCIA
MNFYQMCFYLALHIPLTK*FVG*TK*KYLHLYSW
ETPFSVHLCSFI*ETPL*KHL**MGTFTIMI*E
ATDCHSCFPALQNCSRSGMPV*PLSSIIFPFFP
LFESLYI*FLTKIVLLNILNPGN*KFGCIFFTSK
ERTTSYKKYFGISIVLV*GTYFG*RHQTEVNSC
ASNLL*FCK*QYVIKLLGDLRVEPPISLFSTVC
DSNHFSVLFIIPLISTYFSPG*NFNFYKITF*IK
HTVCSVG*TMNTVINVQFKSLKV*I*KLVKMTI
SITLGEPLLSSLNPFSTI*NKHTKLYD*YNLKI
FYTEGLVITLEDVMH**KSTHHFLLVFNVLETVK
*YCRTCLLL*KLNVRAE*IKVSRHICIEAKVFY
SNNCLLNTTTFSLYCI*LWPTMLYLLFIKL*LF
YYCLCQMLTAKLGVT*SIF*KHG*IYFSINYLMK
TKF*KPQVLIVIK*HAAILDC*SFC*YFGCN*N
YVLSHVKSLINSIYQ*YRSQYLL*DQWSGNSLL
YRINWSLCLKKKNFFLTILKLLLNGIILTYSK*G
L*GTGC*SIFSEEWICRSLSFYRNIVLTQVLNY
FFYELVYFLKFKHILLITLFLEHPALLLTFQQG
KME*SGNFFR*VKYPQVSFLPKKGKVIEMGVASG
VSG*RWVLGVAVKENNGESLF*TSTYT*SKKQS
NLL*STLPLERSIKKSEDGFRKKHEFRNIQNGF
CGRFNIMNSQIFKE*ET**LVEMPETVPGSSCV*
H*ENSKSVKSQILMKSHRCKDSSVEENIPFLQK
EMSIYGVCGK*GKNSYAYESQVVSGRE*SSKLD
YHLSNLE*FEIEKKYLIWIWIC*DMHSLFFV*YW
KIKML*FGYGFFCIHYLPIEERGKSIMQLLSKP
FIFWI*YLKSHEQLHSAYQKAFIK*LLAEDVSK
EILH*GHLSE*CLCLFRVG*PPTPGVKESYCLSF
PNS*DYRHAPGHVFYL*LLKPR*RNHIFAHSEE
TFGH*LVLIFSDCPVFIRLERPCVGHS*YKPLS
LLSKPAHLRFHNFLIVLTQNELRAFHFLFVSSQR
VGSASAFACQDFVLK*MLFGN*NSCQLSCNFDV
TEVGW*FILLILWFFYHIEKAKYSFV*IF
Sequence TPD52.kAug05
CGGGCGGCGCCGCCGCGCCCGACGCCTCTGGGGGTGGGGACTTCGCGGGAGTCGCCGGCGGAGGCGAGGAGGAGCTCTGCGCGGCGCGGCGGGCGATCCGAGCCGGGACGGGCTGCAGGCGGGGGTGCTGCAGAGGACACGAGGCGGCGGGCTGGAGACATGGACCGCGGCGAGCAAGGTCTGCTGAGAACAGACCCAGT
CCCTGAGGAAGGAGAAGATGTTGCTGCCACGATCAGTGCCACAGAGACCCTCTCGGAAGAGGAGCAGGAAGAGCTAAGAAGAGAACTTGCAAAGGTAGAA
GAAGAAATCCAGACTCTGTCTCAAGTGTTAGCAGCAAAAGAGAAGCATCTAGCAGAGATCAAGCGGAAACTTGGAATCAATTCTCTACAGGAACTAAAAC
AGAACATTGCCAAAGGGTGGCAAGACGTGACAGCAACATCTGCGAGGAGCAAGCTTCTAGCAGCAGAAACCGAACTGCTCTGTCTTCTGTATTGAGAGCC
ATCTGCAGAGCTGTTACAAGAAGACATCTGAAACCTTATCCCAGGCTGGACAGAAGGCCTCAGCTGCTTTTTCGTCTGTTGGCTCAGTCATCACCAAAAA
GCTGGAAGATGTAAAATTGCAAGCCTTTTCACATTCCTTTAGTATACGTTCCATTCAGCATTCAATTAGCATGCCTGCTATGAGAAACTCCCCAACTTTT
AAATCATTTGAAGAAAAGGTCGAAAACTTAAAGTCTAAAGTAGGGGGAACCAAGCCTGCTGGTGGTGATTTTGGAGAAGTCTTGAATTCGGCTGCAAATG
CTAGTGCCACCACCACGGAGCCTCTTCCAGAAAAGACACAGGAGAGCCTGTGAGATTCCTACCTTTGTTCTGCTACCCACTGCCAGATGCTGCAAGCGAG
GTCCAAGCACATCTTGTCAACATGCATTGCCATGAATTTCTACCAGATGTGCTTTTATTTAGCTTTACATATTCCTTTGACCAAATAGTTTGTGGGTTAA
ACAAAATGAAAATATCTTCACCTCTATTCTTGGGAAACACCCTTTAGTGTACATTTATGTTCCTTTATTTAGGAAACACCATTATAAAAACACTTATAGT
AAATGGGGACATTCACTATAATGATCTAAGAAGCTACAGATTGTCATAGTTGTTTTCCTGCTTTACAAAATTGCTCCAGATCTGGAATGCCAGTTTGACC
TTTGTCTTCTATAATATTTCCTTTTTTTCCCCTCTTTGAATCTCTGTATATTTGATTCTTAACTAAAATTGTTCTCTTAAATATTCTGAATCCTGGTAAT
TAAAAGTTTGGGTGTATTTTCTTTACCTCCAAGGAAAGAACTACTAGCTACAAAAAATATTTTGGAATAAGCATTGTTTTGGTATAAGGTACATATTTTG
GTTGAAGACACCAGACTGAAGTAAACAGCTGTGCATCCAATTTATTATAGTTTTGTAAGTAACAATATGTAATCAAACTTCTAGGTGACTTGAGAGTGGA
ACCTCCTATATCATTATTTAGCACCGTTTGTGACAGTAACCATTTCAGTGTATTGTTTATTATACCACTTATATCAACTTATTTTTCACCAGGTTAAAAT
TTTAATTTCTACAAAATAACATTCTGAATCAAGCACACTGTATGTTCAGTAGGTTGAACTATGAACACTGTCATCAATGTTCAGTTCAAAAGCCTGAAAG
TTTAGATCTAGAAGCTGGTAAAAATGACAATATCAATCACATTAGGGGAACCATTGTTGTCTTCACTTAATCCATTTAGCACTATTTAAAATAAGCACAC
CAAGTTATATGACTAATATAACTTGAAAATTTTTTATACTGAGGGGTTGGTGATAACTCTTGAGGATGTAATGCATTAATAAAAATCAACTCATCATTTT
CTACTTGTTTTCAATGTGTTGGAAACTGTAAAATGATACTGTAGAACCTGTCTCCTACTTTGAAAACTGAATGTCAGGGCTGAGTGAATCAAAGTGTCTA
GACATATTTGCATAGAGGCCAAGGTATTCTATTCTAATAACTGCTTACTCAACACTACCACCTTTTCCTTATACTGTATATGATTATGGCCTACAATGTT
GTATTTGTTATTTATTAAATTGTGATTGTTTTATTATTGTTTATGCCAAATGTTAACTGCCAAGCTTGGAGTGACCTAAAGCATTTTTTAAAAGCATGGC
TAGATTTACTTCAGTATAAATTATCTTATGAAAACCAAATTTTAAAAGCCACAGGTGTTGATTGTTATAAAATAACATGCTGCCATTCTTGATTGCTAGA
GTTTTTGTTAGTACTTTGGATGCAATTAAAACTATGTGCTATCACATGTGAAAAGCTTAATAAATTCCATCTATCAGTAGTATAGGTCTCAATATTTATT
ATGAGACCAGTGGTCTGGAAACAGCTTGTTGTACCGAATCAACTGGAGTCTATGCTTAAAAAAAAAAAATTTTTTTTTAACCATCCTTAAATTATTGCTT
AATGGTATCATATTAACATATTCTAAATAAGGGCTTTAAGGCACAGGCTGTTGAAGCATTTTCTCAGAGGAGTGGATCTGTAGAAGTCTGTCTTTCTATA
GAAATATTGTGCTTACTCAAGTGTTAAATTATTTTTTCTATGAACTAGTCTACTTCTTAAAATTCAAACATATTCTTTTGATCACATTGTTTCTTGAGCA
TCCTGCCCTGCTACTAACTTTTCAACAAGGCAAAATGGAGTAAAGTGGCAATTTCTTTAGATGAGTGAAATACCCTCAAGTCTCTTTTCTGCCCAAAAAG
GGAAAAGTGATAGAAATGGGGGTGGCAAGTGGGGTGAGTGGATGAAGGTGGGTATTGGGGGTGGCTGTGAAAGAAAATAATGGAGAATCACTTTTCTAGA
CATCTACCTATACTTAATCTAAGAAACAAAGTAATCTACTGTAAAGTACTCTGCCCCTTGAAAGAAGTATTAAAAAGAGTGAGGATGGATTTAGAAAAAA
ACATGAATTTAGAAATATTCAAAATGGTTTTTGTGGCAGATTCAATATTATGAATTCACAGATATTTAAAGAATGAGAAACATAGTAATTAGTAGAAATG
CCAGAAACAGTTCCTGGTTCCTCTTGTGTTTGACACTAAGAAAATAGCAAGAGTGTGAAATCTCAGATACTTATGAAATCTCACAGATGTAAGGACTCAA
GTGTAGAAGAAAATATCCCCTTCTTACAAAAAGAAATGTCAATTTATGGAGTTTGTGGGAAATAGGGCAAGAATTCTTATGCTTATGAGAGCCAAGTAGT
CAGTGGAAGAGAGTAGAGCTCAAAACTGGATTATCACCTTAGCAACTTAGAATAGTTTGAAATAGAAAAAAAGTATTTAATTTGGATCTGGATCTGTTAA
GATATGCACAGTCTATTTTTTGTATAGTATTGGAAAATAAAAATGCTATAATTTGGGTATGGGTTCTTTTGTATACATTACCTGCCCATTGAGGAAAGGG
GCAAGTCCATTATGCAACTTCTCTCCAAACCCTTCATATTCTGGATATGATACTTAAAGAGCCATGAGCAGCTACATTCTGCCTATCAGAAGGCATTTAT
TAAATGACTGCTTGCTGAAGATGTGTCCAAAGAGATCCTACATTAAGGTCATTTGTCAGAATGATGTTTGTGTTTGTTTAGAGTTGGCTGACCTCCAACT
CCTGGGGTCAAGGAATCCTACTGCCTTAGCTTCCCAAATAGCTAGGACTATAGGCATGCACCCGGCCATGTGTTTTATTTATAGCTCTTAAAGCCCAGAT
GAAGAAATCACATTTTTGCCCATAGTGAAGAAACATTTGGCCATTGATTAGTCCTTATTTTCAGTGACTGTCCTGTTTTCATTAGATTAGAGAGACCCTG
TGTGGGCCACAGTTAATATAAACCATTATCACTTTTAAGTAAACCTGCACATCTTAGATTTCATAATTTCCTTATTGTTCTGACTCAAAATGAACTAAGA
GCTTTTCACTTTTTGTTTGTAAGTTCTCAGAGAGTCGGGTCTGCAAGTGCTTTTGCCTGCCAGGATTTTGTACTCAAATAAATGCTATTTGGCAACTAAA
ATTCTTGCCAGCTCTCATGTAATTTTGATGTTACTGAGGTTGGTTGGTAGTTTATTTTATTAATTTTGTGGTTCTTCTATCATATAGAAAAAGCCAAATA
CAGTTTTGTTTGAATATTTGT
- TPD52.F12 (forward primer)
- TPD52.R11 (reverse primer)
- Single exon skipping
Frame 0
RAAPPRPTPLGVGTSRESPAEARRSSARRGGRSEPGRAAGGGAAEDTRRRAGDMDRGEQGLLRTDPV
PEEGEDVAATISATETLSEEEQEELRRELAKVE
EEIQTLSQVLAAKEKHLAEIKRKLGINSLQELK
QNIAKGWQDVTATSARSKLLAAETELLCLLY*EP
SAELLQEDI*NLIPGWTEGLSCFFVCWLSHHQK
AGRCKIASLFTFL*YTFHSAFN*HACYEKLPNF
*II*RKGRKLKV*SRGNQACWW*FWRSLEFGCKC
*CHHHGASSRKDTGEPVRFLPLFCYPLPDAASE
VQAHLVNMHCHEFLPDVLLFSFTYSFDQIVCGL
NKMKISSPLFLGNTL*CTFMFLYLGNTIIKTLIV
NGDIHYNDLRSYRLS*LFSCFTKLLQIWNASLT
FVFYNISFFSPL*ISVYLILN*NCSLKYSESW*
LKVWVYFLYLQGKNY*LQKIFWNKHCFGIRYIFW
LKTPD*SKQLCIQFIIVL*VTICNQTSR*LESG
TSYIII*HRL*Q*PFQCIVYYTTYINLFFTRLK
F*FLQNNILNQAHCMFSRLNYEHCHQCSVQKPES
LDLEAGKNDNINHIRGTIVVFT*SI*HYLK*AH
QVI*LI*LENFLY*GVGDNS*GCNALIKINSSF
STCFQCVGNCKMIL*NLSPTLKTECQG*VNQSV*
TYLHRGQGILF**LLTQHYHLFLILYMIMAYNV
VFVIY*IVIVLLLFMPNVNCQAWSDLKHFLKAW
LDLLQYKLSYENQILKATGVDCYKITCCHS*LLE
FLLVLWMQLKLCAITCEKLNKFHLSVV*VSIFI
MRPVVWKQLVVPNQLESMLKKKKFFFNHP*IIA
*WYHINIF*IRALRHRLLKHFLRGVDL*KSVFL*
KYCAYSSVKLFFL*TSLLLKIQTYSFDHIVS*A
SCPATNFSTRQNGVKWQFL*MSEIPSSLFSAQK
GKSDRNGGGKWGEWMKVGIGGGCERK*WRITFLD
IYLYLI*ETK*STVKYSAP*KKY*KE*GWI*KK
T*I*KYSKWFLWQIQYYEFTDI*RMRNIVISRN
ARNSSWFLLCLTLRK*QECEISDTYEISQM*GLK
CRRKYPLLTKRNVNLWSLWEIGQEFLCL*EPSS
QWKRVELKTGLSP*QLRIV*NRKKVFNLDLDLL
RYAQSIFCIVLENKNAIIWVWVLLYTLPAH*GKG
QVHYATSLQTLHILDMILKEP*AATFCLSEGIY
*MTAC*RCVQRDPTLRSFVRMMFVFV*SWLTSN
SWGQGILLP*LPK*LGL*ACTRPCVLFIALKAQM
KKSHFCP**RNIWPLISPYFQ*LSCFH*IRETL
CGPQLI*TIITFK*TCTS*IS*FPYCSDSK*TK
SFSLFVCKFSESRVCKCFCLPGFCTQINAIWQLK
FLPALM*F*CY*GWLVVYFINFVVLLSYRKSQI
QFCLNIC
Frame 1
GRRRRARRLWGWGLRGSRRRRRGGALRGAAGDPSRDGLQAGVLQRTRGGGLETWTAASKVC*EQTQ
SLRKEKMLLPRSVPQRPSRKRSRKS*EENLQR*K
KKSRLCLKC*QQKRSI*QRSSGNLESILYRN*N
RTLPKGGKT*QQHLRGASF*QQKPNCSVFCIES
HLQSCYKKTSETLSQAGQKASAAFSSVGSVITKK
LEDVKLQAFSHSFSIRSIQHSISMPAMRNSPTF
KSFEEKVENLKSKVGGTKPAGGDFGEVLNSAAN
ASATTTEPLPEKTQESL*DSYLCSATHCQMLQAR
SKHILSTCIAMNFYQMCFYLALHIPLTK*FVG*
TK*KYLHLYSWETPFSVHLCSFI*ETPL*KHL*
*MGTFTIMI*EATDCHSCFPALQNCSRSGMPV*P
LSSIIFPFFPLFESLYI*FLTKIVLLNILNPGN
*KFGCIFFTSKERTTSYKKYFGISIVLV*GTYF
G*RHQTEVNSCASNLL*FCK*QYVIKLLGDLRVE
PPISLFSTVCDSNHFSVLFIIPLISTYFSPG*N
FNFYKITF*IKHTVCSVG*TMNTVINVQFKSLK
V*I*KLVKMTISITLGEPLLSSLNPFSTI*NKHT
KLYD*YNLKIFYTEGLVITLEDVMH**KSTHHF
LLVFNVLETVK*YCRTCLLL*KLNVRAE*IKVS
RHICIEAKVFYSNNCLLNTTTFSLYCI*LWPTML
YLLFIKL*LFYYCLCQMLTAKLGVT*SIF*KHG
*IYFSINYLMKTKF*KPQVLIVIK*HAAILDC*
SFC*YFGCN*NYVLSHVKSLINSIYQ*YRSQYLL
*DQWSGNSLLYRINWSLCLKKKNFFLTILKLLL
NGIILTYSK*GL*GTGC*SIFSEEWICRSLSFY
RNIVLTQVLNYFFYELVYFLKFKHILLITLFLEH
PALLLTFQQGKME*SGNFFR*VKYPQVSFLPKK
GKVIEMGVASGVSG*RWVLGVAVKENNGESLF*
TSTYT*SKKQSNLL*STLPLERSIKKSEDGFRKK
HEFRNIQNGFCGRFNIMNSQIFKE*ET**LVEM
PETVPGSSCV*H*ENSKSVKSQILMKSHRCKDS
SVEENIPFLQKEMSIYGVCGK*GKNSYAYESQVV
SGRE*SSKLDYHLSNLE*FEIEKKYLIWIWIC*
DMHSLFFV*YWKIKML*FGYGFFCIHYLPIEER
GKSIMQLLSKPFIFWI*YLKSHEQLHSAYQKAFI
K*LLAEDVSKEILH*GHLSE*CLCLFRVG*PPT
PGVKESYCLSFPNS*DYRHAPGHVFYL*LLKPR
*RNHIFAHSEETFGH*LVLIFSDCPVFIRLERPC
VGHS*YKPLSLLSKPAHLRFHNFLIVLTQNELR
AFHFLFVSSQRVGSASAFACQDFVLK*MLFGN*
NSCQLSCNFDVTEVGW*FILLILWFFYHIEKAKY
SFV*IF
Frame 2
GGAAAPDASGGGDFAGVAGGGEEELCAARRAIRAGTGCRRGCCRGHEAAGWRHGPRRARSAENRPS
P*GRRRCCCHDQCHRDPLGRGAGRAKKRTCKGR
RRNPDSVSSVSSKREASSRDQAETWNQFSTGTKT
EHCQRVARRDSNICEEQASSSRNRTALSSVLRA
ICRAVTRRHLKPYPRLDRRPQLLFRLLAQSSPK
SWKM*NCKPFHIPLVYVPFSIQLACLL*ETPQLL
NHLKKRSKT*SLK*GEPSLLVVILEKS*IRLQM
LVPPPRSLFQKRHRRACEIPTFVLLPTARCCKR
GPSTSCQHALP*ISTRCAFI*LYIFL*PNSLWVK
QNENIFTSILGKHPLVYIYVPLFRKHHYKNTYS
KWGHSL**SKKLQIVIVVFLLYKIAPDLECQFD
LCLL*YFLFFPSLNLCIFDS*LKLFS*IF*ILVI
KSLGVFSLPPRKELLATKNILE*ALFWYKVHIL
VEDTRLK*TAVHPIYYSFVSNNM*SNF*VT*EW
NLLYHYLAPFVTVTISVYCLLYHLYQLIFHQVKI
LISTK*HSESSTLYVQ*VEL*TLSSMFSSKA*K
FRSRSW*K*QYQSH*GNHCCLHLIHLALFKIST
PSYMTNIT*KFFILRGW**LLRM*CINKNQLIIF
YLFSMCWKL*NDTVEPVSYFEN*MSGLSESKCL
DIFA*RPRYSILITAYSTLPPFPYTVYDYGLQC
CICYLLNCDCFIIVYAKC*LPSLE*PKAFFKSMA
RFTSV*IIL*KPNFKSHRC*LL*NNMLPFLIAR
VFVSTLDAIKTMCYHM*KA**IPSISSIGLNIY
YETSGLETACCTESTGVYA*KKKIFF*PSLNYCL
MVSY*HILNKGFKAQAVEAFSQRSGSVEVCLSI
EILCLLKC*IIFSMN*STS*NSNIFF*SHCFLS
ILPCY*LFNKAKWSKVAISLDE*NTLKSLFCPKR
EK**KWGWQVG*VDEGGYWGWL*KKIMENHFSR
HLPILNLRNKVIYCKVLCPLKEVLKRVRMDLEK
NMNLEIFKMVFVADSIL*IHRYLKNEKHSN**KC
QKQFLVPLVFDTKKIARV*NLRYL*NLTDVRTQ
V*KKISPSYKKKCQFMEFVGNRARILMLMRAK*
SVEESRAQNWIITLAT*NSLK*KKSI*FGSGSVK
ICTVYFLYSIGK*KCYNLGMGSFVYITCPLRKG
ASPLCNFSPNPSYSGYDT*RAMSSYILPIRRHL
LNDCLLKMCPKRSYIKVICQNDVCVCLELADLQL
LGSRNPTALASQIARTIGMHPAMCFIYSS*SPD
EEITFLPIVKKHLAID*SLFSVTVLFSLD*RDP
VWATVNINHYHF*VNLHILDFIISLLF*LKMN*E
LFTFCL*VLRESGLQVLLPARILYSNKCYLATK
ILASSHVILMLLRLVGSLFY*FCGSSII*KKPN
TVLFEYL
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