Back to Rnomics Platform
 Open Session
×
1 warning:
  • Access restricted to public data.
    Please sign in at Rnomics Platform to access your data.
Navigation
Home
Sequences

Sequence CTSB.eAug05

GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCG
CGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGTCTTCAGGCCTATGGAGAGCAGCTTGCGTGGGCTGGGCCTGCAGTACCTGGTTTGCATAG
ATGATTGGCAGGTGGGCAGCACGGGGAAGGACCTGTGAGTGGCCAACCTGGTTCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCT
CCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCAC
GTGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATG
TTTACCGAGGACCTGAAGCTGCCTGCAAGCTTCGATGCACGGGAACAATGGCCACAGTGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCT
CCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGGATCTGCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCAC
ATGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCCTGCTGAAGCTTGGAACTTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTAT
GAATCCCATGTAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAGCACCACGTCAACGGCTCCCGGCCCCCATGCACGGGGGAGGGAGATACCCCCAAGT
GTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGGACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCAT
GGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAG
ATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACA
ATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTA
ATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTC
TGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGC
CACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATC
TCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTT
CCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCAC
AACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGA
CCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGG
AAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCC
AACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACTTGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGA
ACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCAT
CCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCAAAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAG
AGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCAGCTCACTGCAACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTC
CGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATTTTTGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAA
CTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAAT
CCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTCTTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGA
TGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTT
TGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCTCAG
TACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCAAGTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGA
TCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTGTTAAGCATCTCTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACG
CCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAA
AATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGC
AGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCGCAAGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCA
GTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCC
CATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGA
GGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATG
CTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAAGTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCA
AACTGAGTTGATTCATTCCATGCGCACTGTCTCCCTCACCTCCATCGTATACGCACCTGCAGCTCCTTGCCTGCTTCTAGCATGGAGCCAGCGGGGATGT
GCTGGTGAGTGACAAGGAATTGTGGGGCATGTCGACATCAGCTTAAGGCTTTGTTAGAAACACCTGCCTTGCAGTGTTTGTGACTGGGAAAGAGCTCAGT
GTTTTAATACACCTCAGATCACCACATTGATCATAACTTTGTCACCTCAGTTCAATAGTTTCTCCTGGATTCTTGTCCAAGTGAGATGACAGGTGGACGT
AACAATGCCTTTTCAGTCTTTACCTAGCCTCTCCAGAGAATCACTCCAGAATAGAAATTAGAGTATAGGTAGGCAGTCCAACCTCTGCATTT
  • CTSB.F2 (forward primer)
  • CTSB.R6 (reverse primer)
  • Multiple exon skipping

Frame 0

GAGPGGYLGPGLAQATAAAGLRQPLRQRQPLRC
AQAGLQALGCSAGCLQAYGEQLAWAGPAVPGLHR
*LAGGQHGEGPVSGQPGSGGSRIRLPTCGSSGP
PSAACWCWPMPGAGPLSIPCRMSWSTMSTNGIP
RGRPGTTSTTWT*AT*RGYVVPSWVGPSHPRELC
LPRT*SCLQASMHGNNGHSVPPSKRSETRAPVA
PAGPSGLWKPSLTGSASTPMRTSAWRCRRRTCS
HAVAACVGTAVMVAILLKLGTSGQEKAWFLVASM
NPM*GADRTPSLPVSTTSTAPGPHARGREIPPS
VARSVSLATARPTNRTSTTDTIPTASPIARRTS
WPRSTKTAPWRELSLCIRTSCSTSQECTNTSPER
*WVAMPSASWAGEWRMAHPTGWLPTPGTLTGVT
MASLKYSEDRITVESNQKWWLEFHAPISTGKRS
NLPWACRASPGGEIGVEMHFIL*VHVRYKFQTGS
EGLDWPNIRPVFQGDQVLATSQPVVTVQTGHVS
HRCQHRASFPL*TSAVGSTCCPS*LWPPP*SIH
LQGARQRRRNGKRSS*QDESSPISSPSTSKQVAF
HICHRNQRRDGVGSPLENASLPGPLHLSSLQCH
NLSDLVLSMIL**KFYFFVHSANHVGEPVEQRE
TCASFTDCLLMTRLKRKPSGQELFLTH*SLLPQG
K*FRRNQLLLFLKNYSFTLSS*QGMPVPIKVFS
NLKSTLMGSQILCHCL*TCSCCLSLSLQRITSW
NCMFLRLLGLHLNFSLPQPCFQPWHPSPN*FPVI
LVNLLCKCLVSLPLLKNSKHSCALFFCCCCD*Q
SEIPSPRLECSGAFSAHCNLQPPRFKRFSCFSL
PSSWDDRHSPICLGNFCIFKYIQDFTMLARLVSN
SRPQVVCLPQPPKVLGLQA*ATGPCLYFLSATN
PATS*GFSS*NRLGVLVISHNQDATPWGTTSPW
MPSSLGLGWSQGLYTVF*ICMPLVCIAGQEL*CF
A*PWFRNML*QFLV*SKLEEPAIIPLSCQGTPQ
YSPSQLKWYEASSFQKHSSLASDVTQNLGTRC*
IK*ALKI*GTL*ERFVKHLLSAMMSITAGRRGSR
L*SQHFGRPRWEDDKVRSSRPAWPTC*NLTSTK
NTKISWAWWHMPVIPATWEAEAGESLEPGRRRL
Q*AKTVPVHSSLGDSARLRLNN*KKKKKKKGRAQ
WLKPVIPALWEAEAGRSPEVRSFEISLGNTVKP
HLY*KYKISQACWHMPVIPATREAEVRESLEPG
RQRMQ*AEITPLHSSLGDKSESVSHQKKKEKERC
LTKVTISHKFITTYPSSFK*NIFITSIKFSLLP
N*VDSFHAHCLPHLHRIRTCSSLPASSMEPAGM
CW*VTRNCGACRHQLKALLETPALQCL*LGKSSV
F*YTSDHHIDHNFVTSVQ*FLLDSCPSEMTGGR
NNAFSVFT*PLQRITPE*KLEYR*AVQPLH

Frame 1

GRGREGT*GRGWPRLRRLQGSGNRSGNANRSAA
RRLGCRLSAAALGVFRPMESSLRGLGLQYLVCI
DDWQVGSTGKDL*VANLVQVDLGSGFQHVAALGL
PLLPAGVGQCPEQALFPSPVG*AGQLCQQTEYH
VAGRAQLLQRGHELLEEAMWYLPGWAQATPESY
VYRGPEAACKLRCTGTMATVSHHQRDQRPGLLWL
LLGLRGCGSHL*PDLHPHQCARQRGGVGGGPAH
MLWQHVWGRL*WWLSC*SLELLDKKRPGFWWPL
*IPCRVQTVLHPSL*APRQRLPAPMHGGGRYPQV
*QDL*AWLQPDLQTGQALRIQFLQRLQ*REGHH
GRDLQKRPRGGSFLCVFGLPALQVRSVPTRHRR
DDGWPCHPHPGLGSGEWHTLLAGCQLLEH*LG*Q
WLL*NTQRTGSLWNRIRSGGWNSTHRSVLGKDL
ICRGPVVPVLGARSG*KCILFFKFT*DTSFRQG
LKDWIGQTSDLSSKETKSWLHPSLWLQCRQAM*A
TAASTERPSPCRLVP*GVPAAPADCGPLRDPSI
SREQDRDAGMESGVPNRMKVPPSVPPVPPSK*L
STFVTEIRGETVLGALWRTPVSQAPCIYRVCNVT
TSLILCSA*FFNRSFIFSCTLLIMWVSQWNSGR
PVLVLQIASL*RGSKGNQVVRSCF*PTDLYYHK
ENSLGETSFYCF*KITASPCQVNKECLCQ*KFSP
T*SLL*WDLRSFVTAYRLVAAVSLCPCRESRPG
TACSCDSWDFILTSRCPSHVFNHGIPPPISSLS
SSSTFSVSAW*ACPCLRTQNIAVLYFFVVVVTDR
VRFRLPGWSAVAPSQLTATCSLLDSSDSPASAF
RVAGMTGTHQYAWVIFVFLSTYRISPCWPG*FQ
TPGLRWSACLSLPKCWDYRREPLGPACIFYQPQI
QQQAEDSAHKTGLVSW*SHITKMLPRGEPHPPG
CPPALVWAGVRACIQYFEFVCHWFALLVRNSSA
LHSPGLETCYSSSWYRAN*KNQQSFHCPAKVHLS
TPLPN*SGMRLALSKSIQVWLLM*LRI*EPDAR
SNKL*KSEEHCRKGLLSIS*VP**A*QPAVVAH
ACNPSTLGGQGGRMTRSGVQDQPGQHAETSPLLK
IQKLAGHGGTCL*SQLLGRLRQENRLNPGGGGC
SEPRQCQCTPASVTAQGSVSIIKKKKKKKKAGR
SGSSL*SQHFGRLRRADHLRSGVLRSALATR*NP
ISTKNTKLAKHAGTCL*SQLLGRLRYENRLNLG
GRGCSEPRSRHCTPAWGTRVNLCLTKKKKKKKD
A*QRLP*ATNS*PLILPVSSRIYS*PQ*SSPCSQ
TELIHSMRTVSLTSIVYAPAAPCLLLAWSQRGC
AGE*QGIVGHVDISLRLC*KHLPCSVCDWERAQ
CFNTPQITTLIITLSPQFNSFSWILVQVR*QVDV
TMPFQSLPSLSRESLQNRN*SIGRQSNLCI

Frame 2

GGAGRVLRAGAGPGYGGCRAPATAPATPTAPLR
AGWAAGSRLQRWVSSGLWRAACVGWACSTWFA*
MIGRWAARGRTCEWPTWFRWI*DPASNMWQLWA
SLCCLLVLANARSRPSFHPLSDELVNYVNKRNTT
WQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVM
FTEDLKLPASFDAREQWPQCPTIKEIRDQGSCG
SCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLT
CCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLY
ESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPK
CSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGE
MMGGHAIRILGWGVENGTPYWLVANSWNTDWGD
NGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI*
SAVGLSCQSWGRDRGRNAFYSLSSRKIQVSDRV
*RTGLAKHQTCLPRRPSPGYIPACGYSADRPCE
PPLPAQSVLPPVD*CRREYLLPQLTVAPSVIHPS
PGSKTETQEWKAEFLTG*KFPHQFPQYLQASSF
PHLSQKSEERRCWEPFGERQSPRPPASIEFAMS
QPL*SCAQHDSLIEVLFFRALC*SCG*ASGTAGD
LC*FYRLPPYDAAQKETKWSGVVSDPLISTTTR
KIV*EKPAFTVFEKLQLHPVKLTRNACANKSFL
QLEVYSDGISDPLSLPIDL*LLSLFVPAENHVLE
LHVLATLGTSS*LLAAPAMFSTMASLPQLVPCH
PRQPSL*VPGKLALA*ELKT*LCSIFLLLL*LT
E*DSVSQAGVQWRLLSSLQPAAS*IQAILLLQPS
E*LG*QALTNMPG*FLYF*VHTGFHHVGQASFK
LPASGGLPASASQSVGITGVSHWALPVFFISHK
SSNKLRIQLIKQAWCLGDLT*PRCYPVGNHIPLD
ALQPWFGLESGPVYSILNLYATGLHCWSGTLVL
CIALV*KHVIAVLGIEQTRRTSNHSTVLPRYTS
VLPFPTEVV*G*LFPKAFKFGF*CDSEFRNQMLD
QISSENLRNIVGKVC*ASLKCHDEHNSRPSWLT
PVIPALWEAKVGG*QGQEFKTSLANMLKPHLY*
KYKN*LGMVAHACNPSYLGG*GRRIA*TREAEVA
VSQDSASALQPR*QRKAPSQ*LKKKKKKKRPGA
VAQACNPSTLGG*GGQIT*GQEF*DQPWQHGET
PSLLKIQN*PSMLAHACNPSYSGG*GTRIA*TWE
AEDAVSRDHAIALQPGGQE*ICVSPKKKRKRKM
LNKGYHKPQIHNHLSFQFQVEYIHNLNKVLPAP
KLS*FIPCALSPSPPSYTHLQLLACF*HGASGDV
LVSDKELWGMSTSA*GFVRNTCLAVFVTGKELS
VLIHLRSPH*S*LCHLSSIVSPGFLSK*DDRWT
*QCLFSLYLASPENHSRIEIRV*VGSPTSAF

Sequence CTSB.cAug05

GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCG
CGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGTCTTCAGGCCTATGGAGAGCAGCTTGCGTGGGCTGGGCCTGCAGTACCTGGTTTGCATAG
ATGATTGGCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCT
CTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTT
GAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATGTTTACCGAGGACCTGAAGCTGCCTGCAAGCTTCGATGCACGGGAA
CAATGGCCACAGTGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCTCCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGGATCT
GCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCACATGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCC
TGCTGAAGCTTGGAACTTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTATGAATCCCATGTAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAG
CACCACGTCAACGGCTCCCGGCCCCCATGCACGGGGGAGGGAGATACCCCCAAGTGTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGG
ACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGT
GTATTCGGACTTCCTGCTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAG
AATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCG
AATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGG
TAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGA
CCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCC
GTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCT
AACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCC
TTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTT
TATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAA
GGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTA
CAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGC
CTATAGACTTGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGC
TGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCT
TAAGAACTCAAAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCA
GCTCACTGCAACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATT
TTTGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTT
GGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAATCCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTC
TTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGATGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAG
TATTTTGAATTTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTTTGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATA
GAGCAAACTAGAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCTCAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAA
AAGCATTCAAGTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTG
TTAAGCATCTCTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAA
GGTCAGGAGTTCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCA
GCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCG
CAAGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGG
CAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATG
CCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCC
TGGGGGACAAGAGTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATGCTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCC
TTCCAGTTTCAAGTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCAAACTGAGTTGATTCATTCCATGCGCACTGTCTCCCTCACCTCCAT
CGTATACGCACCTGCAGCTCCTTGCCTGCTTCTAGCATGGAGCCAGCGGGGATGTGCTGGTGAGTGACAAGGAATTGTGGGGCATGTCGACATCAGCTTA
AGGCTTTGTTAGAAACACCTGCCTTGCAGTGTTTGTGACTGGGAAAGAGCTCAGTGTTTTAATACACCTCAGATCACCACATTGATCATAACTTTGTCAC
CTCAGTTCAATAGTTTCTCCTGGATTCTTGTCCAAGTGAGATGACAGGTGGACGTAACAATGCCTTTTCAGTCTTTACCTAGCCTCTCCAGAGAATCACT
CCAGAATAGAAATTAGAGTATAGGTAGGCAGTCCAACCTCTGCATTT
  • CTSB.F2 (forward primer)
  • CTSB.R6 (reverse primer)
  • Multiple exon skipping

Frame 0

GAGPGGYLGPGLAQATAAAGLRQPLRQRQPLRC
AQAGLQALGCSAGCLQAYGEQLAWAGPAVPGLHR
*LAGGSRIRLPTCGSSGPPSAACWCWPMPGAGP
LSIPCRMSWSTMSTNGIPRGRPGTTSTTWT*AT
*RGYVVPSWVGPSHPRELCLPRT*SCLQASMHGN
NGHSVPPSKRSETRAPVAPAGPSGLWKPSLTGS
ASTPMRTSAWRCRRRTCSHAVAACVGTAVMVAI
LLKLGTSGQEKAWFLVASMNPM*GADRTPSLPVS
TTSTAPGPHARGREIPPSVARSVSLATARPTNR
TSTTDTIPTASPIARRTSWPRSTKTAPWRELSL
CIRTSCSTSQECTNTSPER*WVAMPSASWAGEWR
MAHPTGWLPTPGTLTGVTMASLKYSEDRITVES
NQKWWLEFHAPISTGKRSNLPWACRASPGGEIG
VEMHFIL*VHVRYKFQTGSEGLDWPNIRPVFQGD
QVLATSQPVVTVQTGHVSHRCQHRASFPL*TSA
VGSTCCPS*LWPPP*SIHLQGARQRRRNGKRSS
*QDESSPISSPSTSKQVAFHICHRNQRRDGVGSP
LENASLPGPLHLSSLQCHNLSDLVLSMIL**KF
YFFVHSANHVGEPVEQRETCASFTDCLLMTRLK
RKPSGQELFLTH*SLLPQGK*FRRNQLLLFLKNY
SFTLSS*QGMPVPIKVFSNLKSTLMGSQILCHC
L*TCSCCLSLSLQRITSWNCMFLRLLGLHLNFS
LPQPCFQPWHPSPN*FPVILVNLLCKCLVSLPLL
KNSKHSCALFFCCCCD*QSEIPSPRLECSGAFS
AHCNLQPPRFKRFSCFSLPSSWDDRHSPICLGN
FCIFKYIQDFTMLARLVSNSRPQVVCLPQPPKVL
GLQA*ATGPCLYFLSATNPATS*GFSS*NRLGV
LVISHNQDATPWGTTSPWMPSSLGLGWSQGLYT
VF*ICMPLVCIAGQEL*CFA*PWFRNML*QFLV*
SKLEEPAIIPLSCQGTPQYSPSQLKWYEASSFQ
KHSSLASDVTQNLGTRC*IK*ALKI*GTL*ERF
VKHLLSAMMSITAGRRGSRL*SQHFGRPRWEDDK
VRSSRPAWPTC*NLTSTKNTKISWAWWHMPVIP
ATWEAEAGESLEPGRRRLQ*AKTVPVHSSLGDS
ARLRLNN*KKKKKKKGRAQWLKPVIPALWEAEAG
RSPEVRSFEISLGNTVKPHLY*KYKISQACWHM
PVIPATREAEVRESLEPGRQRMQ*AEITPLHSS
LGDKSESVSHQKKKEKERCLTKVTISHKFITTYP
SSFK*NIFITSIKFSLLPN*VDSFHAHCLPHLH
RIRTCSSLPASSMEPAGMCW*VTRNCGACRHQL
KALLETPALQCL*LGKSSVF*YTSDHHIDHNFVT
SVQ*FLLDSCPSEMTGGRNNAFSVFT*PLQRIT
PE*KLEYR*AVQPLH

Frame 1

GRGREGT*GRGWPRLRRLQGSGNRSGNANRSAA
RRLGCRLSAAALGVFRPMESSLRGLGLQYLVCI
DDWQVDLGSGFQHVAALGLPLLPAGVGQCPEQAL
FPSPVG*AGQLCQQTEYHVAGRAQLLQRGHELL
EEAMWYLPGWAQATPESYVYRGPEAACKLRCTG
TMATVSHHQRDQRPGLLWLLLGLRGCGSHL*PDL
HPHQCARQRGGVGGGPAHMLWQHVWGRL*WWLS
C*SLELLDKKRPGFWWPL*IPCRVQTVLHPSL*
APRQRLPAPMHGGGRYPQV*QDL*AWLQPDLQTG
QALRIQFLQRLQ*REGHHGRDLQKRPRGGSFLC
VFGLPALQVRSVPTRHRRDDGWPCHPHPGLGSG
EWHTLLAGCQLLEH*LG*QWLL*NTQRTGSLWNR
IRSGGWNSTHRSVLGKDLICRGPVVPVLGARSG
*KCILFFKFT*DTSFRQGLKDWIGQTSDLSSKE
TKSWLHPSLWLQCRQAM*ATAASTERPSPCRLVP
*GVPAAPADCGPLRDPSISREQDRDAGMESGVP
NRMKVPPSVPPVPPSK*LSTFVTEIRGETVLGA
LWRTPVSQAPCIYRVCNVTTSLILCSA*FFNRSF
IFSCTLLIMWVSQWNSGRPVLVLQIASL*RGSK
GNQVVRSCF*PTDLYYHKENSLGETSFYCF*KI
TASPCQVNKECLCQ*KFSPT*SLL*WDLRSFVTA
YRLVAAVSLCPCRESRPGTACSCDSWDFILTSR
CPSHVFNHGIPPPISSLSSSSTFSVSAW*ACPC
LRTQNIAVLYFFVVVVTDRVRFRLPGWSAVAPSQ
LTATCSLLDSSDSPASAFRVAGMTGTHQYAWVI
FVFLSTYRISPCWPG*FQTPGLRWSACLSLPKC
WDYRREPLGPACIFYQPQIQQQAEDSAHKTGLVS
W*SHITKMLPRGEPHPPGCPPALVWAGVRACIQ
YFEFVCHWFALLVRNSSALHSPGLETCYSSSWY
RAN*KNQQSFHCPAKVHLSTPLPN*SGMRLALSK
SIQVWLLM*LRI*EPDARSNKL*KSEEHCRKGL
LSIS*VP**A*QPAVVAHACNPSTLGGQGGRMT
RSGVQDQPGQHAETSPLLKIQKLAGHGGTCL*SQ
LLGRLRQENRLNPGGGGCSEPRQCQCTPASVTA
QGSVSIIKKKKKKKKAGRSGSSL*SQHFGRLRR
ADHLRSGVLRSALATR*NPISTKNTKLAKHAGTC
L*SQLLGRLRYENRLNLGGRGCSEPRSRHCTPA
WGTRVNLCLTKKKKKKKDA*QRLP*ATNS*PLI
LPVSSRIYS*PQ*SSPCSQTELIHSMRTVSLTSI
VYAPAAPCLLLAWSQRGCAGE*QGIVGHVDISL
RLC*KHLPCSVCDWERAQCFNTPQITTLIITLS
PQFNSFSWILVQVR*QVDVTMPFQSLPSLSRESL
QNRN*SIGRQSNLCI

Frame 2

GGAGRVLRAGAGPGYGGCRAPATAPATPTAPLR
AGWAAGSRLQRWVSSGLWRAACVGWACSTWFA*
MIGRWI*DPASNMWQLWASLCCLLVLANARSRP
SFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYL
KRLCGTFLGGPKPPQRVMFTEDLKLPASFDARE
QWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRI
CIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYP
AEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCE
HHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQ
DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV
YSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVE
NGTPYWLVANSWNTDWGDNGFFKILRGQDHCGI
ESEVVAGIPRTDQYWEKI*SAVGLSCQSWGRDRG
RNAFYSLSSRKIQVSDRV*RTGLAKHQTCLPRR
PSPGYIPACGYSADRPCEPPLPAQSVLPPVD*C
RREYLLPQLTVAPSVIHPSPGSKTETQEWKAEFL
TG*KFPHQFPQYLQASSFPHLSQKSEERRCWEP
FGERQSPRPPASIEFAMSQPL*SCAQHDSLIEV
LFFRALC*SCG*ASGTAGDLC*FYRLPPYDAAQK
ETKWSGVVSDPLISTTTRKIV*EKPAFTVFEKL
QLHPVKLTRNACANKSFLQLEVYSDGISDPLSL
PIDL*LLSLFVPAENHVLELHVLATLGTSS*LLA
APAMFSTMASLPQLVPCHPRQPSL*VPGKLALA
*ELKT*LCSIFLLLL*LTE*DSVSQAGVQWRLL
SSLQPAAS*IQAILLLQPSE*LG*QALTNMPG*F
LYF*VHTGFHHVGQASFKLPASGGLPASASQSV
GITGVSHWALPVFFISHKSSNKLRIQLIKQAWC
LGDLT*PRCYPVGNHIPLDALQPWFGLESGPVYS
ILNLYATGLHCWSGTLVLCIALV*KHVIAVLGI
EQTRRTSNHSTVLPRYTSVLPFPTEVV*G*LFP
KAFKFGF*CDSEFRNQMLDQISSENLRNIVGKVC
*ASLKCHDEHNSRPSWLTPVIPALWEAKVGG*Q
GQEFKTSLANMLKPHLY*KYKN*LGMVAHACNP
SYLGG*GRRIA*TREAEVAVSQDSASALQPR*QR
KAPSQ*LKKKKKKKRPGAVAQACNPSTLGG*GG
QIT*GQEF*DQPWQHGETPSLLKIQN*PSMLAH
ACNPSYSGG*GTRIA*TWEAEDAVSRDHAIALQP
GGQE*ICVSPKKKRKRKMLNKGYHKPQIHNHLS
FQFQVEYIHNLNKVLPAPKLS*FIPCALSPSPP
SYTHLQLLACF*HGASGDVLVSDKELWGMSTSA*
GFVRNTCLAVFVTGKELSVLIHLRSPH*S*LCH
LSSIVSPGFLSK*DDRWT*QCLFSLYLASPENH
SRIEIRV*VGSPTSAF

Sequence CTSB.qAug05

GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCG
CGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGGTCTTGCTTTGTCTCCCAGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGC
CACCCAGATGTAAGCGATCTGGTTCCCACCTCAGCCTCCCGAGTAGATACTTCTGAAAATAGAAATGATGACTCTGGGATGCAAACGTTGGCTGTCCTAT
GTATAAGGAGATGGCTTTTCACGCTCCCAGTGACTGAGGAAGTTTCTCCCAGATGGCGCTGCTCTGAGCCTGGTGCAGGGTGTCTTCAGGCCTATGGAGA
GCAGCTTGCGTGGGCTGGGCCTGCAGTACCTGGTTTGCATAGATGATTGGCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCC
TCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATGTTT
ACCGAGGACCTGAAGCTGCCTGCAAGCTTCGATGCACGGGAACAATGGCCACAGTGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCTCCT
GCTGGGTAAGGCCCTGCTGGCTGGCGGGGAAGCGCTGGAGAGAAAGTGGGAGCAACACTGGAGAGTCTTGGGGGATTCGGGGTGGGGACAACTCTGACAA
GGCAAGTTATAGAAACTTTCTGAGTCCCAGTTTCCATCAGTACAAAAATCACAATCCCTCTGGCCATGAATGATGGCGAGGATTAGGTGGAGTGGCGGGC
AGAGCATCCAGCAGATTGCAAGTCCACGTGTACAGGTGGCGAAGCAGCTCCCTTTCCCTGACATGCTGGCCCGTCCGCAAATACCAGGAGCTCTCACTGC
TACTCTGCTTCAAGAAAGCATCCCTTTAGTGTCAGTGAGCTGTCTTAATTTTGTCATTTAATTGTGGTAAAATACACGTAACAGAAATGTAATAATCTTA
GCAATCTTCTTTTGTTTTCTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTGGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGGGAT
ATTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGTCTCCCCAGTAGCTAAGACTACAGGCATGTGCCACCACGCCCAGCTA
ATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGGACAGCCTGGTCTCAAACGCCTCACCTGTTGATCTGCCTTCCTCGGCCTCGCAAAATGCT
GGGATTACAGGCGTGAGCCACCGTGCCCAGCAACTATTTTCAAGTGTACAGTTCTGTAGCATTAAGTACATTCACAGTGTTGCTCAGCCACCACCACCAT
CTGTCCCCCGAACTCTTTTTCAGCTCGCAAGACAGAAACTCTGTCCCCATTAACACCAATATTGTAGCCCCTGGTAAGCCCCACTCTACTTTCTGTCTCT
ATGAATTTGACTCCTAGGGACCTCATACAAGTGGATCACAACAGTATTTATTTTCTGGGTGAGCTGTGTTTTTTGTTAAGAAAAAAACACAGCCAGGTAC
GGTAGCTCACGCCTGTAATCTCAACACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAGGTCAGGAGTTTGAGACCAACCTGGCCAACATGGTGAAACCC
TGTCTCTACTAAAAAGACAAAACTTAGCTGGGCCTGGTGGCAGGCACCTATAATCCCAGCTACTATAGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGG
AGGCGTAGGTTGCAGTGAGCTGAGATTGCGCCACTGCATTCCAGCCTGGGCAACAAAAGTGAAACTCCGCCTCCAGGAAAAAAAAAAAAAACCACACACA
CACATACAAACTAATACTACACATTTTGCAGATTTCAGAAATGAACCCAGTTTCCAGGCAGAGGTTCACGGGGGTGCTTCTCTTGCTTTAAAAGCTGAGT
TGGGCAAATCGTTGAGGCAGGAGAGTGGGGCAAGTGGCTCATCACGCCTCTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAAATCACTTGAACCCGGG
AGTTCAAGACCAGTCTGGCCAACGTAGCAAGACCCCATTTCTACCAAAGAAAATAAAAGCTGAGTTTGAGCCCCAGGAGCGTCCCCTGGTGTTGAGAGAT
CAGTTGCCTACAAGGTCTGAGGTGCCCCTGTGGCCCTTTGAGGGGACTGCTGCAGAGGGCCCAGCCCGGACATGGCAGCCTCACCCGGTGGGGCTCGTTC
CTGCAGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGGATCTGCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCACAT
GCTGTGGCAGCATGTGTGGGGACGGGTGAGTCAGGCTGTGCTTCCACAGCGGGTTTAGTGCTGAGAGACCCTGGGCCCCAGCTTCTCAGTGGAGGGGACT
TTGAGGACTTCCTGGGACTGCTGCGAGTCAGAAGTGTTTCGGGGAGACTCCGAGAGTCTGGCAGGCAGGGCCTGGCAAGGCTGCTGCTTCCTGGGAGGTG
CCTGAACCAAGGCTGGCCCGGCAGAGCTGTCTGAGGGGTGGCATCCCAGCAAAACAGTCAGTTTCAGAAAATGTGGTGGAATGTCTGGCCCCTGGTCTGG
TTTGTGTCATCGCATGTTCCTTTTTCCTGCTTGGGGAACCAGTTTGGGGCATTTCCTTATGTGTAGTTAGCGGGGATGGCTCCACCTTAACAACAAGGTG
GTGGCACAGAACTTTCTGCTCCAGCTGCCTGCAGCCTCGCCTTGGTTCCGCAGTAGCGGTGTTCACTGGCGGCTGCAGATCCGAAATGCCTGAGGGCTTA
AAAAAATGCATGGGCTTCTCCCCTAACTAGTTAAATGGGAATCACTGGCGATTCTCATTTCAGAGAACTGGTGGTGTTTTTAAGTACCTTAGGGAAGTTT
AGCGTCTGCTCAGTTGAGAATCAGTGTTCTACCCGGAAGGGCACTCGTAGCCTGGTCTGGTATGGACATGAACAGGAGAGCCTCCTGTCTTCTCCCGGAT
CTTTGTGGGCAGGGGTGGGGCTGGCGGTTATTCCCTGCAAGCTGTGCTTATCTAGGGAGCGTCCCTTGGAGGGTTTGGGGTCTGGGAGGTCTGCTCGCAC
CACTTGCTGCAGCTGGGGGTGGGTCCACGAGTGGCCTCGGGCACTTGGGTAGCACACAGTGGTCTGGAGAGCTGGTGGTGCTTCTCTCAGAGGTTTTCAT
TAGAGGCTGTCTTTTCAGCTGTAATGGTGGCTATCCTGCTGAAGCTTGGAACTTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTATGAATCCCAT
GTAGGTAAGTGTGTCCCCTTGGCCACTTTCTGGCCAGATGGATTGTTTGAGCAATTAACCATCATGGCTTTATTTGCCTTTATAAACTGGGGGTTGAGAC
AGAGGGGCTGCTGAGAGGTGCTAGCCAGGTGCACAGGCCTCTGGCAGGACCTGCCTGGCGTCCATGCTGCAGGCACGAGGCTTGCCTTGCCCCAGGTCTT
CTCCGTGGGGGCTGTAGGTTGACTCCGCTTTCTCCCGCGTCCCATCAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAGCACCACGTCAACGGCTCCCG
GCCCCCATGCACGGGGGAGGGAGATACCCCCAAGTGTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGGACAAGCACTACGGTAAGGGG
CCTGGGGCCTGGCCACGGCGCACGTGGAGGCTGGGGAGCTGCTGCATCCCTCCTCACGCTGCAGCGAAGAGGTCAGGGCTGAGGAGCCTTGGGGTCCCGG
AACTCTAGGATAGAGGAGGGGGAGTGATGCCCTCTTGCCAGGAGAAGCAGCACACTCTCCACTTTCTGCCTGTTCCACCCTGAACTCAGCCTCAGCCCTT
CCAAACTGGAAGGGACCAAAGCCCTCCTTTTACAAGGGAGTGGCGTGTCCTGGAGTCTTGAGGTATCCTGGCCTCTTCCGGGGCCTCGTGCTCATTGCTC
CGTTCTCCCATTTCTGAGCTTCCAGCCCCAGCCCTGTCCTTAGTTCTTCAGGGGAGCCTTCCTTGAGCTCCCCTGGCAGGGCAAGTCCCCTTAGATGCAG
TCTTCCCCTGGAGGCCACCAGAAATCAGTGACTGGCTGACCGTGGCGTGCCACGAGGCACGGTCACTGCCCTCCCCAACCCCGAGCTCGGTTCATTTTCC
AGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGAC
TTCCTGCTCTACAAGTCAGGTGCGTGCTGATGGCTGATGGCAATAGAGGGTGGGGGTCGGGAGGGGAGCCTGGGTGCCAGGATGGTTCATGTTGACCAAT
AGGGCTGGATTGGGCAGGCAGGTGAGGGGCTGGGGAAGAGGGCTGTGTGGGGCCTTCCATATAGGCTCACTCCTCTGTGGACCAGCCTGGCACCTGACTG
TCTTTGTCCAGGTGTTGTGCCAACACACACAATTCCAGAGGCCTCTCCCAGAGCCTCTGGGCTAGTTCCTTCCCATCCATTAGCGTCCAGCTCATACATG
TTCTCTGTGGGAACGCCCCCCTCCCTGGTGGCTGGCCACGCCTGCCCTCGCCTTCCTGGCTTTGCATTGCTTTACCAGCATGTTTCTGTTATAATGGCAG
GCCGTTCGTGTTTGCACTGGCTGACACATTTTCTTCATCTTTCTCTTTGCAAAGGCCTAGATCGTGCCTCACACCAGTGGATGAACACACAGGGAGGACC
TTGCCCTGGGTAGTGCCATAGGGACTCCAACCAAGGAATCTGGACAGTCCCCATCCCCAAGTCCTGTCTTAGAAATCCCTTGCTCCAGATGAACAGTCTT
TGCTGACTGCATCTATCCCATTAATATTTTGCTAGATTGGAAACTTGTAAAACAACAGTTTGACAAAGGAAGATGATTCTGGCAAGAAAAAGTTTCTGTG
AAGATGGCACTTCTTAGCATAGTCCTCGCCCTTATTATTAAAAGATGCATTTCCACTTTGACAGTGATTTCCCCACCCGAGAGCCTGGTTGGGCAGCCCT
GAGCCCCTTAGCCAGTATCTTTCCCATCAGCTAGCATTAGCTGCCACCAGTCCTCCCTTCTCCTCCCTCACCTCTTCAGGGTGTACCTGGAGCAGCTATT
AAAACTCTTTAAGCCGTGTAACGCTTTTGACAAACCCTTACTTACATGGAATCCCAGTATAAAGAACAGATGAATCAGTCATCTAGCATTAAATGTTTTA
TCAATTAGAATGTATTAGAAATTCTATTTTTAAAGCCAACAAGCACATTTTGTAGGAATCTATTTCAATATTTACTCAACAACTTTGAGTGTGTTGGGCC
TTCAAAAATATATTTAATTCCCCAGTATTGTGGGACCCCCCCTGGAGCCTCCTGGTGGAGCAGCAGGTTCCCTCTGGAAGCTGTTTCTCCTTCCCGGAGC
ATGACCAGCTGAGTGTGGGGGGTGCTGTGGGGCGTGGGACAGTGGCCCGGTCTCGGTCTCAGCCAGTTCTTCCCTTTTCAGGAGTGTACCAACACGTCAC
CGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGG
GGTGACAATGGTGAGTGGCTGCCCCCTTCCTGCCAAGAACAGTGAATTGTGAGCCACACCCCGTGGCCATCTCGGCTTTCTCTGTTCTACCCACCGCACA
GCCTTAAACCCTGGACCTACGGCCAGGCTGTGAGCTCCTCCTAAGTGCCAGGCAGTCAGGAGTTCCCTTTTGCTGTGAGGGCAGACTCTGAGCAGCTTCA
GAGCCAACGCCTGCAACAGTTCCCACAGCATCGCGCCAGATCCTGTGATGGGAAGGGTGACCGGGCAGGGGGCTTGCCCGTGGAGGTGTGCCCCACGGCT
CCAGAAGCCTTGTGGTGTTGAGGACTGTGCTAGTGGGCCAACAGCAGGAGTGGCCAGGGATGAGTGACTTAAGGTCTTTTAAGGATGAGTCTGACTATAT
TGGTTGACCCTTGTCACACTTTAAAAGCACCTTACTTTTTATTCCCAGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGT
GGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCA
TTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTG
GCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTA
CCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGA
AAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAAC
GCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCG
TGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAG
TGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACC
CTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACTT
GTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCC
ATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCA
AAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCAGCTCACTGCA
ACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATTTTTGTATTTT
TAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAG
GCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAATCCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTCTTGGTGATCT
CACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGATGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAAT
TTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTTTGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTA
GAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCTCAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCAA
GTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTGTTAAGCATCT
CTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAAGGTCAGGAGT
TCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGG
AGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCGCAAGGCTCCG
TCTCAATAATT
  • CTSB.F2 (forward primer)
  • CTSB.R6 (reverse primer)
  • Multiple exon skipping

Frame 0

GAGPGGYLGPGLAQATAAAGLRQPLRQRQPLRC
AQAGLQALGCSAGVLLCLPGWCAVVRPRLTAASA
TQM*AIWFPPQPPE*ILLKIEMMTLGCKRWLSY
V*GDGFSRSQ*LRKFLPDGAALSLVQGVFRPME
SSLRGLGLQYLVCIDDWQVDLGSGFQHVAALGLP
LLPAGVGQCPEQALFPSPVG*AGQLCQQTEYHV
AGRAQLLQRGHELLEEAMWYLPGWAQATPESYV
YRGPEAACKLRCTGTMATVSHHQRDQRPGLLWLL
LGKALLAGGEALERKWEQHWRVLGDSGWGQL*Q
GKL*KLSESQFPSVQKSQSLWP*MMARIRWSGG
QSIQQIASPRVQVAKQLPFPDMLARPQIPGALTA
TLLQESIPLVSVSCLNFVI*LW*NTRNRNVIIL
AIFFCFLFLSFFFFFFFGDGVLLCHPGWSAVVG
YWLTATSASWVQAILLPQSPQ*LRLQACATTPS*
FLYF**RWGFAMLDSLVSNASPVDLPSSASQNA
GITGVSHRAQQLFSSVQFCSIKYIHSVAQPPPP
SVPRTLFQLARQKLCPH*HQYCSPW*APLYFLSL
*I*LLGTSYKWITTVFIFWVSCVFC*EKNTARY
GSSRL*SQHFGRLRQADHLRSGV*DQPGQHGET
LSLLKRQNLAGPGGRHL*SQLL*RLRQENCLNPG
GVGCSELRLRHCIPAWATKVKLRLQEKKKKPHT
HIQTNTTHFADFRNEPSFQAEVHGGASLALKAE
LGKSLRQESGASGSSRL*SQHFGRPRWANHLNPG
VQDQSGQRSKTPFLPKKIKAEFEPQERPLVLRD
QLPTRSEVPLWPFEGTAAEGPARTWQPHPVGLV
PAGLRGCGSHL*PDLHPHQCARQRGGVGGGPAHM
LWQHVWGRVSQAVLPQRV*C*ETLGPSFSVEGT
LRTSWDCCESEVFRGDSESLAGRAWQGCCFLGG
A*TKAGPAELSEGWHPSKTVSFRKCGGMSGPWSG
LCHRMFLFPAWGTSLGHFLMCS*RGWLHLNNKV
VAQNFLLQLPAASPWFRSSGVHWRLQIRNA*GL
KKMHGLLP*LVKWESLAILISENWWCF*VP*GSL
ASAQLRISVLPGRALVAWSGMDMNRRASCLLPD
LCGQGWGWRLFPASCAYLGSVPWRVWGLGGLLA
PLAAAGGGSTSGLGHLGSTQWSGELVVLLSEVFI
RGCLFSCNGGYPAEAWNFWTRKGLVSGGLYESH
VGKCVPLATFWPDGLFEQLTIMALFAFINWGLR
QRGC*EVLARCTGLWQDLPGVHAAGTRLALPQVF
SVGAVG*LRFLPRPIRVQTVLHPSL*APRQRLP
APMHGGGRYPQV*QDL*AWLQPDLQTGQALR*G
AWGLATAHVEAGELLHPSSRCSEEVRAEEPWGPG
TLG*RRGSDALLPGEAAHSPLSACSTLNSASAL
PNWKGPKPSFYKGVACPGVLRYPGLFRGLVLIA
PFSHF*ASSPSPVLSSSGEPSLSSPGRASPLRCS
LPLEATRNQ*LADRGVPRGTVTALPNPELGSFS
RIQFLQRLQ*REGHHGRDLQKRPRGGSFLCVFG
LPALQVRCVLMADGNRGWGSGGEPGCQDGSC*PI
GLDWAGR*GAGEEGCVGPSI*AHSSVDQPGT*L
SLSRCCANTHNSRGLSQSLWASSFPSISVQLIH
VLCGNAPLPGGWPRLPSPSWLCIALPACFCYNGR
PFVFALADTFSSSFSLQRPRSCLTPVDEHTGRT
LPWVVP*GLQPRNLDSPHPQVLS*KSLAPDEQS
LLTASIPLIFC*IGNL*NNSLTKEDDSGKKKFL*
RWHFLA*SSPLLLKDAFPL*Q*FPHPRAWLGSP
EPLSQYLSHQLALAATSPPFSSLTSSGCTWSSY
*NSLSRVTLLTNPYLHGIPV*RTDESVI*H*MFY
QLECIRNSIFKANKHIL*ESISIFTQQL*VCWA
FKNIFNSPVLWDPPWSLLVEQQVPSGSCFSFPE
HDQLSVGGAVGRGTVARSRSQPVLPFSGVYQHVT
GEMMGGHAIRILGWGVENGTPYWLVANSWNTDW
GDNGEWLPPSCQEQ*IVSHTPWPSRLSLFYPPH
SLKPWTYGQAVSSS*VPGSQEFPFAVRADSEQLQ
SQRLQQFPQHRARSCDGKGDRAGGLPVEVCPTA
PEALWC*GLC*WANSRSGQG*VT*GLLRMSLTI
LVDPCHTLKAPYFLFPGFFKILRGQDHCGIESEV
VAGIPRTDQYWEKI*SAVGLSCQSWGRDRGRNA
FYSLSSRKIQVSDRV*RTGLAKHQTCLPRRPSP
GYIPACGYSADRPCEPPLPAQSVLPPVD*CRREY
LLPQLTVAPSVIHPSPGSKTETQEWKAEFLTG*
KFPHQFPQYLQASSFPHLSQKSEERRCWEPFGE
RQSPRPPASIEFAMSQPL*SCAQHDSLIEVLFFR
ALC*SCG*ASGTAGDLC*FYRLPPYDAAQKETK
WSGVVSDPLISTTTRKIV*EKPAFTVFEKLQLH
PVKLTRNACANKSFLQLEVYSDGISDPLSLPIDL
*LLSLFVPAENHVLELHVLATLGTSS*LLAAPA
MFSTMASLPQLVPCHPRQPSL*VPGKLALA*EL
KT*LCSIFLLLL*LTE*DSVSQAGVQWRLLSSLQ
PAAS*IQAILLLQPSE*LG*QALTNMPG*FLYF
*VHTGFHHVGQASFKLPASGGLPASASQSVGIT
GVSHWALPVFFISHKSSNKLRIQLIKQAWCLGDL
T*PRCYPVGNHIPLDALQPWFGLESGPVYSILN
LYATGLHCWSGTLVLCIALV*KHVIAVLGIEQT
RRTSNHSTVLPRYTSVLPFPTEVV*G*LFPKAFK
FGF*CDSEFRNQMLDQISSENLRNIVGKVC*AS
LKCHDEHNSRPSWLTPVIPALWEAKVGG*QGQE
FKTSLANMLKPHLY*KYKN*LGMVAHACNPSYLG
G*GRRIA*TREAEVAVSQDSASALQPR*QRKAP
SQ*

Frame 1

GRGREGT*GRGWPRLRRLQGSGNRSGNANRSAA
RRLGCRLSAAALGSCFVSQAGVQWCDHGSRQPQ
PPRCKRSGSHLSLPSRYF*K*K**LWDANVGCPM
YKEMAFHAPSD*GSFSQMALL*AWCRVSSGLWR
AACVGWACSTWFA*MIGRWI*DPASNMWQLWAS
LCCLLVLANARSRPSFHPLSDELVNYVNKRNTTW
QAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMF
TEDLKLPASFDAREQWPQCPTIKEIRDQGSCGS
CWVRPCWLAGKRWRESGSNTGESWGIRGGDNSDK
ASYRNFLSPSFHQYKNHNPSGHE*WRGLGGVAG
RASSRLQVHVYRWRSSSLSLTCWPVRKYQELSL
LLCFKKASL*CQ*AVLILSFNCGKIHVTEM**S*
QSSFVFFFFLFFFFFFLEMESCSVTQAGVQWWD
IGSLQPLPPGFKQFSCLSLPSS*DYRHVPPRPA
NFCIFSRDGVLPCWTAWSQTPHLLICLPRPRKML
GLQA*ATVPSNYFQVYSSVALSTFTVLLSHHHH
LSPELFFSSQDRNSVPINTNIVAPGKPHSTFCL
YEFDS*GPHTSGSQQYLFSG*AVFFVKKKTQPGT
VAHACNLNTLGG*GRRIT*GQEFETNLANMVKP
CLY*KDKT*LGLVAGTYNPSYYRG*GRRIA*TQ
EA*VAVS*DCATAFQPGQQK*NSASRKKKKNHTH
TYKLILHILQISEMNPVSRQRFTGVLLLL*KLS
WANR*GRRVGQVAHHASNPSTLGGQGGQIT*TR
EFKTSLANVARPHFYQRK*KLSLSPRSVPWC*EI
SCLQGLRCPCGPLRGLLQRAQPGHGSLTRWGSF
LQAFGAVEAISDRICIHTNAHVSVEVSAEDLLT
CCGSMCGDG*VRLCFHSGFSAERPWAPASQWRGL
*GLPGTAASQKCFGETPRVWQAGPGKAAASWEV
PEPRLARQSCLRGGIPAKQSVSENVVECLAPGL
VCVIACSFFLLGEPVWGISLCVVSGDGSTLTTRW
WHRTFCSSCLQPRLGSAVAVFTGGCRSEMPEGL
KKCMGFSPN*LNGNHWRFSFQRTGGVFKYLREV
*RLLS*ESVFYPEGHS*PGLVWT*TGEPPVFSRI
FVGRGGAGGYSLQAVLI*GASLGGFGVWEVCSH
HLLQLGVGPRVASGTWVAHSGLESWWCFSQRFS
LEAVFSAVMVAILLKLGTSGQEKAWFLVASMNPM
*VSVSPWPLSGQMDCLSN*PSWLYLPL*TGG*D
RGAAERC*PGAQASGRTCLASMLQARGLPCPRS
SPWGL*VDSAFSRVPSGCRPYSIPPCEHHVNGSR
PPCTGEGDTPKCSKICEPGYSPTYKQDKHYGKG
PGAWPRRTWRLGSCCIPPHAAAKRSGLRSLGVP
EL*DRGGGVMPSCQEKQHTLHFLPVPP*TQPQPF
QTGRDQSPPFTREWRVLES*GILASSGASCSLL
RSPISELPAPALSLVLQGSLP*APLAGQVPLDA
VFPWRPPEISDWLTVACHEARSLPSPTPSSVHFP
GYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSD
FLLYKSGAC*WLMAIEGGGREGSLGARMVHVDQ
*GWIGQAGEGLGKRAVWGLPYRLTPLWTSLAPDC
LCPGVVPTHTIPEASPRASGLVPSHPLASSSYM
FSVGTPPSLVAGHACPRLPGFALLYQHVSVIMA
GRSCLHWLTHFLHLSLCKGLDRASHQWMNTQGGP
CPG*CHRDSNQGIWTVPIPKSCLRNPLLQMNSL
C*LHLSH*YFARLETCKTTV*QRKMILARKSFC
EDGTS*HSPRPYY*KMHFHFDSDFPTREPGWAAL
SPLASIFPIS*H*LPPVLPSPPSPLQGVPGAAI
KTL*AV*RF*QTLTYMESQYKEQMNQSSSIKCF
IN*NVLEILFLKPTSTFCRNLFQYLLNNFECVGP
SKIYLIPQYCGTPPGASWWSSRFPLEAVSPSRS
MTS*VWGVLWGVGQWPGLGLSQFFPFQECTNTS
PER*WVAMPSASWAGEWRMAHPTGWLPTPGTLTG
VTMVSGCPLPAKNSEL*ATPRGHLGFLCSTHRT
ALNPGPTARL*APPKCQAVRSSLLL*GQTLSSF
RANACNSSHSIAPDPVMGRVTGQGACPWRCAPRL
QKPCGVEDCASGPTAGVARDE*LKVF*G*V*LY
WLTLVTL*KHLTFYSQASLKYSEDRITVESNQK
WWLEFHAPISTGKRSNLPWACRASPGGEIGVEMH
FIL*VHVRYKFQTGSEGLDWPNIRPVFQGDQVL
ATSQPVVTVQTGHVSHRCQHRASFPL*TSAVGS
TCCPS*LWPPP*SIHLQGARQRRRNGKRSS*QDE
SSPISSPSTSKQVAFHICHRNQRRDGVGSPLEN
ASLPGPLHLSSLQCHNLSDLVLSMIL**KFYFF
VHSANHVGEPVEQRETCASFTDCLLMTRLKRKPS
GQELFLTH*SLLPQGK*FRRNQLLLFLKNYSFT
LSS*QGMPVPIKVFSNLKSTLMGSQILCHCL*T
CSCCLSLSLQRITSWNCMFLRLLGLHLNFSLPQP
CFQPWHPSPN*FPVILVNLLCKCLVSLPLLKNS
KHSCALFFCCCCD*QSEIPSPRLECSGAFSAHC
NLQPPRFKRFSCFSLPSSWDDRHSPICLGNFCIF
KYIQDFTMLARLVSNSRPQVVCLPQPPKVLGLQ
A*ATGPCLYFLSATNPATS*GFSS*NRLGVLVI
SHNQDATPWGTTSPWMPSSLGLGWSQGLYTVF*I
CMPLVCIAGQEL*CFA*PWFRNML*QFLV*SKL
EEPAIIPLSCQGTPQYSPSQLKWYEASSFQKHS
SLASDVTQNLGTRC*IK*ALKI*GTL*ERFVKHL
LSAMMSITAGRRGSRL*SQHFGRPRWEDDKVRS
SRPAWPTC*NLTSTKNTKISWAWWHMPVIPATW
EAEAGESLEPGRRRLQ*AKTVPVHSSLGDSARLR
LNN

Frame 2

GGAGRVLRAGAGPGYGGCRAPATAPATPTAPLR
AGWAAGSRLQRWGLALSPRLVCSGATTAHGSLS
HPDVSDLVPTSASRVDTSENRNDDSGMQTLAVL
CIRRWLFTLPVTEEVSPRWRCSEPGAGCLQAYGE
QLAWAGPAVPGLHR*LAGGSRIRLPTCGSSGPP
SAACWCWPMPGAGPLSIPCRMSWSTMSTNGIPR
GRPGTTSTTWT*AT*RGYVVPSWVGPSHPRELCL
PRT*SCLQASMHGNNGHSVPPSKRSETRAPVAP
AG*GPAGWRGSAGEKVGATLESLGGFGVGTTLT
RQVIETF*VPVSISTKITIPLAMNDGED*VEWRA
EHPADCKSTCTGGEAAPFP*HAGPSANTRSSHC
YSASRKHPFSVSELS*FCHLIVVKYT*QKCNNL
SNLLLFSFSFFFFFFFFWRWSLALSPRLECSGGI
LAHCNLCLLGSSNSPASVSPVAKTTGMCHHAQL
IFVFLVEMGFCHVGQPGLKRLTC*SAFLGLAKC
WDYRREPPCPATIFKCTVL*H*VHSQCCSATTTI
CPPNSFSARKTETLSPLTPIL*PLVSPTLLSVS
MNLTPRDLIQVDHNSIYFLGELCFLLRKKHSQV
R*LTPVISTLWEAEAGGSPEVRSLRPTWPTW*NP
VSTKKTKLSWAWWQAPIIPATIEAEAGELLEPR
RRRLQ*AEIAPLHSSLGNKSETPPPGKKKKTTH
THTN*YYTFCRFQK*TQFPGRGSRGCFSCFKS*V
GQIVEAGEWGKWLITPLIPALWEAKVGKSLEPG
SSRPVWPT*QDPISTKENKS*V*APGASPGVER
SVAYKV*GAPVAL*GDCCRGPSPDMAASPGGARS
CRPSGLWKPSLTGSASTPMRTSAWRCRRRTCSH
AVAACVGTGESGCASTAGLVLRDPGPQLLSGGD
FEDFLGLLRVRSVSGRLRESGRQGLARLLLPGRC
LNQGWPGRAV*GVASQQNSQFQKMWWNVWPLVW
FVSSHVPFSCLGNQFGAFPYV*LAGMAPP*QQG
GGTELSAPAACSLALVPQ*RCSLAAADPKCLRA*
KNAWASPLTS*MGITGDSHFRELVVFLSTLGKF
SVCSVENQCSTRKGTRSLVWYGHEQESLLSSPG
SLWAGVGLAVIPCKLCLSRERPLEGLGSGRSART
TCCSWGWVHEWPRALG*HTVVWRAGGASLRGFH
*RLSFQL*WWLSC*SLELLDKKRPGFWWPL*IP
CR*VCPLGHFLARWIV*AINHHGFICLYKLGVET
EGLLRGASQVHRPLAGPAWRPCCRHEACLAPGL
LRGGCRLTPLSPASHQGADRTPSLPVSTTSTAP
GPHARGREIPPSVARSVSLATARPTNRTSTTVRG
LGPGHGARGGWGAAASLLTLQRRGQG*GALGSR
NSRIEEGE*CPLARRSSTLSTFCLFHPELSLSP
SKLEGTKALLLQGSGVSWSLEVSWPLPGPRAHCS
VLPFLSFQPQPCP*FFRGAFLELPWQGKSP*MQ
SSPGGHQKSVTG*PWRATRHGHCPPQPRARFIF
QDTIPTASPIARRTSWPRSTKTAPWRELSLCIRT
SCSTSQVRADG*WQ*RVGVGRGAWVPGWFMLTN
RAGLGRQVRGWGRGLCGAFHIGSLLCGPAWHLT
VFVQVLCQHTQFQRPLPEPLG*FLPIH*RPAHTC
SLWERPPPWWLATPALAFLALHCFTSMFLL*WQ
AVRVCTG*HIFFIFLFAKA*IVPHTSG*THRED
LALGSAIGTPTKESGQSPSPSPVLEIPCSR*TVF
ADCIYPINILLDWKLVKQQFDKGR*FWQEKVSV
KMALLSIVLALIIKRCISTLTVISPPESLVGQP
*AP*PVSFPSASISCHQSSLLLPHLFRVYLEQLL
KLFKPCNAFDKPLLTWNPSIKNR*ISHLALNVL
SIRMY*KFYF*SQQAHFVGIYFNIYSTTLSVLG
LQKYI*FPSIVGPPLEPPGGAAGSLWKLFLLPGA
*PAECGGCCGAWDSGPVSVSASSSLFRSVPTRH
RRDDGWPCHPHPGLGSGEWHTLLAGCQLLEH*L
G*QW*VAAPFLPRTVNCEPHPVAISAFSVLPTAQ
P*TLDLRPGCELLLSARQSGVPFCCEGRL*AAS
EPTPATVPTASRQIL*WEG*PGRGLARGGVPHG
SRSLVVLRTVLVGQQQEWPGMSDLRSFKDESDYI
G*PLSHFKSTLLFIPRLL*NTQRTGSLWNRIRS
GGWNSTHRSVLGKDLICRGPVVPVLGARSG*KC
ILFFKFT*DTSFRQGLKDWIGQTSDLSSKETKSW
LHPSLWLQCRQAM*ATAASTERPSPCRLVP*GV
PAAPADCGPLRDPSISREQDRDAGMESGVPNRM
KVPPSVPPVPPSK*LSTFVTEIRGETVLGALWRT
PVSQAPCIYRVCNVTTSLILCSA*FFNRSFIFS
CTLLIMWVSQWNSGRPVLVLQIASL*RGSKGNQ
VVRSCF*PTDLYYHKENSLGETSFYCF*KITASP
CQVNKECLCQ*KFSPT*SLL*WDLRSFVTAYRL
VAAVSLCPCRESRPGTACSCDSWDFILTSRCPS
HVFNHGIPPPISSLSSSSTFSVSAW*ACPCLRTQ
NIAVLYFFVVVVTDRVRFRLPGWSAVAPSQLTA
TCSLLDSSDSPASAFRVAGMTGTHQYAWVIFVF
LSTYRISPCWPG*FQTPGLRWSACLSLPKCWDYR
REPLGPACIFYQPQIQQQAEDSAHKTGLVSW*S
HITKMLPRGEPHPPGCPPALVWAGVRACIQYFE
FVCHWFALLVRNSSALHSPGLETCYSSSWYRAN*
KNQQSFHCPAKVHLSTPLPN*SGMRLALSKSIQ
VWLLM*LRI*EPDARSNKL*KSEEHCRKGLLSI
S*VP**A*QPAVVAHACNPSTLGGQGGRMTRSGV
QDQPGQHAETSPLLKIQKLAGHGGTCL*SQLLG
RLRQENRLNPGGGGCSEPRQCQCTPASVTAQGS
VSII

Copyright ©2008,2017, all rights reserved.