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Sequences

Sequence CTSB.eAug05

GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCG CGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGTCTTCAGGCCTATGGAGAGCAGCTTGCGTGGGCTGGGCCTGCAGTACCTGGTTTGCATAG ATGATTGGCAGGTGGGCAGCACGGGGAAGGACCTGTGAGTGGCCAACCTGGTTCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCT CCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCAC GTGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATG TTTACCGAGGACCTGAAGCTGCCTGCAAGCTTCGATGCACGGGAACAATGGCCACAGTGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCT CCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGGATCTGCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCAC ATGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCCTGCTGAAGCTTGGAACTTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTAT GAATCCCATGTAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAGCACCACGTCAACGGCTCCCGGCCCCCATGCACGGGGGAGGGAGATACCCCCAAGT GTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGGACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCAT GGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAG ATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACA ATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTA ATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTC TGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGC CACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATC TCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTT CCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCAC AACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGA CCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGG AAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCC AACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACTTGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGA ACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCAT CCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCAAAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAG AGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCAGCTCACTGCAACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTC CGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATTTTTGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAA CTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAAT CCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTCTTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGA TGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTT TGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCTCAG TACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCAAGTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGA TCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTGTTAAGCATCTCTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAA AATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGC AGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCGCAAGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCA GTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCC CATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGA GGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATG CTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAAGTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCA AACTGAGTTGATTCATTCCATGCGCACTGTCTCCCTCACCTCCATCGTATACGCACCTGCAGCTCCTTGCCTGCTTCTAGCATGGAGCCAGCGGGGATGT GCTGGTGAGTGACAAGGAATTGTGGGGCATGTCGACATCAGCTTAAGGCTTTGTTAGAAACACCTGCCTTGCAGTGTTTGTGACTGGGAAAGAGCTCAGT GTTTTAATACACCTCAGATCACCACATTGATCATAACTTTGTCACCTCAGTTCAATAGTTTCTCCTGGATTCTTGTCCAAGTGAGATGACAGGTGGACGT AACAATGCCTTTTCAGTCTTTACCTAGCCTCTCCAGAGAATCACTCCAGAATAGAAATTAGAGTATAGGTAGGCAGTCCAACCTCTGCATTT

CTSB.F2 (forward primer)
CTSB.R6 (reverse primer)
Single exon skipping

Frame 0

GAGPGGYLGPGLAQATAAAGLRQPLRQRQPLRC AQAGLQALGCSAGCLQAYGEQLAWAGPAVPGLHR *LAGGQHGEGPVSGQPGSGGSRIRLPTCGSSGP PSAACWCWPMPGAGPLSIPCRMSWSTMSTNGIP RGRPGTTSTTWT*AT*RGYVVPSWVGPSHPRELC LPRT*SCLQASMHGNNGHSVPPSKRSETRAPVA PAGPSGLWKPSLTGSASTPMRTSAWRCRRRTCS HAVAACVGTAVMVAILLKLGTSGQEKAWFLVASM NPM*GADRTPSLPVSTTSTAPGPHARGREIPPS VARSVSLATARPTNRTSTTDTIPTASPIARRTS WPRSTKTAPWRELSLCIRTSCSTSQECTNTSPER *WVAMPSASWAGEWRMAHPTGWLPTPGTLTGVT MASLKYSEDRITVESNQKWWLEFHAPISTGKRS NLPWACRASPGGEIGVEMHFIL*VHVRYKFQTGS EGLDWPNIRPVFQGDQVLATSQPVVTVQTGHVS HRCQHRASFPL*TSAVGSTCCPS*LWPPP*SIH LQGARQRRRNGKRSS*QDESSPISSPSTSKQVAF HICHRNQRRDGVGSPLENASLPGPLHLSSLQCH NLSDLVLSMIL**KFYFFVHSANHVGEPVEQRE TCASFTDCLLMTRLKRKPSGQELFLTH*SLLPQG K*FRRNQLLLFLKNYSFTLSS*QGMPVPIKVFS NLKSTLMGSQILCHCL*TCSCCLSLSLQRITSW NCMFLRLLGLHLNFSLPQPCFQPWHPSPN*FPVI LVNLLCKCLVSLPLLKNSKHSCALFFCCCCD*Q SEIPSPRLECSGAFSAHCNLQPPRFKRFSCFSL PSSWDDRHSPICLGNFCIFKYIQDFTMLARLVSN SRPQVVCLPQPPKVLGLQA*ATGPCLYFLSATN PATS*GFSS*NRLGVLVISHNQDATPWGTTSPW MPSSLGLGWSQGLYTVF*ICMPLVCIAGQEL*CF A*PWFRNML*QFLV*SKLEEPAIIPLSCQGTPQ YSPSQLKWYEASSFQKHSSLASDVTQNLGTRC* IK*ALKI*GTL*ERFVKHLLSAMMSITAGRRGSR L*SQHFGRPRWEDDKVRSSRPAWPTC*NLTSTK NTKISWAWWHMPVIPATWEAEAGESLEPGRRRL Q*AKTVPVHSSLGDSARLRLNN*KKKKKKKGRAQ WLKPVIPALWEAEAGRSPEVRSFEISLGNTVKP HLY*KYKISQACWHMPVIPATREAEVRESLEPG RQRMQ*AEITPLHSSLGDKSESVSHQKKKEKERC LTKVTISHKFITTYPSSFK*NIFITSIKFSLLP N*VDSFHAHCLPHLHRIRTCSSLPASSMEPAGM CW*VTRNCGACRHQLKALLETPALQCL*LGKSSV F*YTSDHHIDHNFVTSVQ*FLLDSCPSEMTGGR NNAFSVFT*PLQRITPE*KLEYR*AVQPLH

Frame 1

GRGREGT*GRGWPRLRRLQGSGNRSGNANRSAA RRLGCRLSAAALGVFRPMESSLRGLGLQYLVCI DDWQVGSTGKDL*VANLVQVDLGSGFQHVAALGL PLLPAGVGQCPEQALFPSPVG*AGQLCQQTEYH VAGRAQLLQRGHELLEEAMWYLPGWAQATPESY VYRGPEAACKLRCTGTMATVSHHQRDQRPGLLWL LLGLRGCGSHL*PDLHPHQCARQRGGVGGGPAH MLWQHVWGRL*WWLSC*SLELLDKKRPGFWWPL *IPCRVQTVLHPSL*APRQRLPAPMHGGGRYPQV *QDL*AWLQPDLQTGQALRIQFLQRLQ*REGHH GRDLQKRPRGGSFLCVFGLPALQVRSVPTRHRR DDGWPCHPHPGLGSGEWHTLLAGCQLLEH*LG*Q WLL*NTQRTGSLWNRIRSGGWNSTHRSVLGKDL ICRGPVVPVLGARSG*KCILFFKFT*DTSFRQG LKDWIGQTSDLSSKETKSWLHPSLWLQCRQAM*A TAASTERPSPCRLVP*GVPAAPADCGPLRDPSI SREQDRDAGMESGVPNRMKVPPSVPPVPPSK*L STFVTEIRGETVLGALWRTPVSQAPCIYRVCNVT TSLILCSA*FFNRSFIFSCTLLIMWVSQWNSGR PVLVLQIASL*RGSKGNQVVRSCF*PTDLYYHK ENSLGETSFYCF*KITASPCQVNKECLCQ*KFSP T*SLL*WDLRSFVTAYRLVAAVSLCPCRESRPG TACSCDSWDFILTSRCPSHVFNHGIPPPISSLS SSSTFSVSAW*ACPCLRTQNIAVLYFFVVVVTDR VRFRLPGWSAVAPSQLTATCSLLDSSDSPASAF RVAGMTGTHQYAWVIFVFLSTYRISPCWPG*FQ TPGLRWSACLSLPKCWDYRREPLGPACIFYQPQI QQQAEDSAHKTGLVSW*SHITKMLPRGEPHPPG CPPALVWAGVRACIQYFEFVCHWFALLVRNSSA LHSPGLETCYSSSWYRAN*KNQQSFHCPAKVHLS TPLPN*SGMRLALSKSIQVWLLM*LRI*EPDAR SNKL*KSEEHCRKGLLSIS*VP**A*QPAVVAH ACNPSTLGGQGGRMTRSGVQDQPGQHAETSPLLK IQKLAGHGGTCL*SQLLGRLRQENRLNPGGGGC SEPRQCQCTPASVTAQGSVSIIKKKKKKKKAGR SGSSL*SQHFGRLRRADHLRSGVLRSALATR*NP ISTKNTKLAKHAGTCL*SQLLGRLRYENRLNLG GRGCSEPRSRHCTPAWGTRVNLCLTKKKKKKKD A*QRLP*ATNS*PLILPVSSRIYS*PQ*SSPCSQ TELIHSMRTVSLTSIVYAPAAPCLLLAWSQRGC AGE*QGIVGHVDISLRLC*KHLPCSVCDWERAQ CFNTPQITTLIITLSPQFNSFSWILVQVR*QVDV TMPFQSLPSLSRESLQNRN*SIGRQSNLCI

Frame 2

GGAGRVLRAGAGPGYGGCRAPATAPATPTAPLR AGWAAGSRLQRWVSSGLWRAACVGWACSTWFA* MIGRWAARGRTCEWPTWFRWI*DPASNMWQLWA SLCCLLVLANARSRPSFHPLSDELVNYVNKRNTT WQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVM FTEDLKLPASFDAREQWPQCPTIKEIRDQGSCG SCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLT CCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLY ESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPK CSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGE MMGGHAIRILGWGVENGTPYWLVANSWNTDWGD NGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI* SAVGLSCQSWGRDRGRNAFYSLSSRKIQVSDRV *RTGLAKHQTCLPRRPSPGYIPACGYSADRPCE PPLPAQSVLPPVD*CRREYLLPQLTVAPSVIHPS PGSKTETQEWKAEFLTG*KFPHQFPQYLQASSF PHLSQKSEERRCWEPFGERQSPRPPASIEFAMS QPL*SCAQHDSLIEVLFFRALC*SCG*ASGTAGD LC*FYRLPPYDAAQKETKWSGVVSDPLISTTTR KIV*EKPAFTVFEKLQLHPVKLTRNACANKSFL QLEVYSDGISDPLSLPIDL*LLSLFVPAENHVLE LHVLATLGTSS*LLAAPAMFSTMASLPQLVPCH PRQPSL*VPGKLALA*ELKT*LCSIFLLLL*LT E*DSVSQAGVQWRLLSSLQPAAS*IQAILLLQPS E*LG*QALTNMPG*FLYF*VHTGFHHVGQASFK LPASGGLPASASQSVGITGVSHWALPVFFISHK SSNKLRIQLIKQAWCLGDLT*PRCYPVGNHIPLD ALQPWFGLESGPVYSILNLYATGLHCWSGTLVL CIALV*KHVIAVLGIEQTRRTSNHSTVLPRYTS VLPFPTEVV*G*LFPKAFKFGF*CDSEFRNQMLD QISSENLRNIVGKVC*ASLKCHDEHNSRPSWLT PVIPALWEAKVGG*QGQEFKTSLANMLKPHLY* KYKN*LGMVAHACNPSYLGG*GRRIA*TREAEVA VSQDSASALQPR*QRKAPSQ*LKKKKKKKRPGA VAQACNPSTLGG*GGQIT*GQEF*DQPWQHGET PSLLKIQN*PSMLAHACNPSYSGG*GTRIA*TWE AEDAVSRDHAIALQPGGQE*ICVSPKKKRKRKM LNKGYHKPQIHNHLSFQFQVEYIHNLNKVLPAP KLS*FIPCALSPSPPSYTHLQLLACF*HGASGDV LVSDKELWGMSTSA*GFVRNTCLAVFVTGKELS VLIHLRSPH*S*LCHLSSIVSPGFLSK*DDRWT *QCLFSLYLASPENHSRIEIRV*VGSPTSAF

Sequence CTSB.cAug05

GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCG CGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGTCTTCAGGCCTATGGAGAGCAGCTTGCGTGGGCTGGGCCTGCAGTACCTGGTTTGCATAG ATGATTGGCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCT CTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTT GAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATGTTTACCGAGGACCTGAAGCTGCCTGCAAGCTTCGATGCACGGGAA CAATGGCCACAGTGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCTCCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGGATCT GCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCACATGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCC TGCTGAAGCTTGGAACTTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTATGAATCCCATGTAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAG CACCACGTCAACGGCTCCCGGCCCCCATGCACGGGGGAGGGAGATACCCCCAAGTGTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGG ACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGT GTATTCGGACTTCCTGCTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAG AATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCG AATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGG TAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGA CCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCC GTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCT AACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCC TTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTT TATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAA GGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTA CAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGC CTATAGACTTGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGC TGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCT TAAGAACTCAAAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCA GCTCACTGCAACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATT TTTGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTT GGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAATCCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTC TTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGATGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAG TATTTTGAATTTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTTTGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATA GAGCAAACTAGAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCTCAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAA AAGCATTCAAGTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTG TTAAGCATCTCTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAA GGTCAGGAGTTCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCA GCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCG CAAGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGG CAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATG CCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCC TGGGGGACAAGAGTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATGCTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCC TTCCAGTTTCAAGTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCAAACTGAGTTGATTCATTCCATGCGCACTGTCTCCCTCACCTCCAT CGTATACGCACCTGCAGCTCCTTGCCTGCTTCTAGCATGGAGCCAGCGGGGATGTGCTGGTGAGTGACAAGGAATTGTGGGGCATGTCGACATCAGCTTA AGGCTTTGTTAGAAACACCTGCCTTGCAGTGTTTGTGACTGGGAAAGAGCTCAGTGTTTTAATACACCTCAGATCACCACATTGATCATAACTTTGTCAC CTCAGTTCAATAGTTTCTCCTGGATTCTTGTCCAAGTGAGATGACAGGTGGACGTAACAATGCCTTTTCAGTCTTTACCTAGCCTCTCCAGAGAATCACT CCAGAATAGAAATTAGAGTATAGGTAGGCAGTCCAACCTCTGCATTT

CTSB.F2 (forward primer)
CTSB.R6 (reverse primer)
Single exon skipping

Frame 0

GAGPGGYLGPGLAQATAAAGLRQPLRQRQPLRC AQAGLQALGCSAGCLQAYGEQLAWAGPAVPGLHR *LAGGSRIRLPTCGSSGPPSAACWCWPMPGAGP LSIPCRMSWSTMSTNGIPRGRPGTTSTTWT*AT *RGYVVPSWVGPSHPRELCLPRT*SCLQASMHGN NGHSVPPSKRSETRAPVAPAGPSGLWKPSLTGS ASTPMRTSAWRCRRRTCSHAVAACVGTAVMVAI LLKLGTSGQEKAWFLVASMNPM*GADRTPSLPVS TTSTAPGPHARGREIPPSVARSVSLATARPTNR TSTTDTIPTASPIARRTSWPRSTKTAPWRELSL CIRTSCSTSQECTNTSPER*WVAMPSASWAGEWR MAHPTGWLPTPGTLTGVTMASLKYSEDRITVES NQKWWLEFHAPISTGKRSNLPWACRASPGGEIG VEMHFIL*VHVRYKFQTGSEGLDWPNIRPVFQGD QVLATSQPVVTVQTGHVSHRCQHRASFPL*TSA VGSTCCPS*LWPPP*SIHLQGARQRRRNGKRSS *QDESSPISSPSTSKQVAFHICHRNQRRDGVGSP LENASLPGPLHLSSLQCHNLSDLVLSMIL**KF YFFVHSANHVGEPVEQRETCASFTDCLLMTRLK RKPSGQELFLTH*SLLPQGK*FRRNQLLLFLKNY SFTLSS*QGMPVPIKVFSNLKSTLMGSQILCHC L*TCSCCLSLSLQRITSWNCMFLRLLGLHLNFS LPQPCFQPWHPSPN*FPVILVNLLCKCLVSLPLL KNSKHSCALFFCCCCD*QSEIPSPRLECSGAFS AHCNLQPPRFKRFSCFSLPSSWDDRHSPICLGN FCIFKYIQDFTMLARLVSNSRPQVVCLPQPPKVL GLQA*ATGPCLYFLSATNPATS*GFSS*NRLGV LVISHNQDATPWGTTSPWMPSSLGLGWSQGLYT VF*ICMPLVCIAGQEL*CFA*PWFRNML*QFLV* SKLEEPAIIPLSCQGTPQYSPSQLKWYEASSFQ KHSSLASDVTQNLGTRC*IK*ALKI*GTL*ERF VKHLLSAMMSITAGRRGSRL*SQHFGRPRWEDDK VRSSRPAWPTC*NLTSTKNTKISWAWWHMPVIP ATWEAEAGESLEPGRRRLQ*AKTVPVHSSLGDS ARLRLNN*KKKKKKKGRAQWLKPVIPALWEAEAG RSPEVRSFEISLGNTVKPHLY*KYKISQACWHM PVIPATREAEVRESLEPGRQRMQ*AEITPLHSS LGDKSESVSHQKKKEKERCLTKVTISHKFITTYP SSFK*NIFITSIKFSLLPN*VDSFHAHCLPHLH RIRTCSSLPASSMEPAGMCW*VTRNCGACRHQL KALLETPALQCL*LGKSSVF*YTSDHHIDHNFVT SVQ*FLLDSCPSEMTGGRNNAFSVFT*PLQRIT PE*KLEYR*AVQPLH

Frame 1

GRGREGT*GRGWPRLRRLQGSGNRSGNANRSAA RRLGCRLSAAALGVFRPMESSLRGLGLQYLVCI DDWQVDLGSGFQHVAALGLPLLPAGVGQCPEQAL FPSPVG*AGQLCQQTEYHVAGRAQLLQRGHELL EEAMWYLPGWAQATPESYVYRGPEAACKLRCTG TMATVSHHQRDQRPGLLWLLLGLRGCGSHL*PDL HPHQCARQRGGVGGGPAHMLWQHVWGRL*WWLS C*SLELLDKKRPGFWWPL*IPCRVQTVLHPSL* APRQRLPAPMHGGGRYPQV*QDL*AWLQPDLQTG QALRIQFLQRLQ*REGHHGRDLQKRPRGGSFLC VFGLPALQVRSVPTRHRRDDGWPCHPHPGLGSG EWHTLLAGCQLLEH*LG*QWLL*NTQRTGSLWNR IRSGGWNSTHRSVLGKDLICRGPVVPVLGARSG *KCILFFKFT*DTSFRQGLKDWIGQTSDLSSKE TKSWLHPSLWLQCRQAM*ATAASTERPSPCRLVP *GVPAAPADCGPLRDPSISREQDRDAGMESGVP NRMKVPPSVPPVPPSK*LSTFVTEIRGETVLGA LWRTPVSQAPCIYRVCNVTTSLILCSA*FFNRSF IFSCTLLIMWVSQWNSGRPVLVLQIASL*RGSK GNQVVRSCF*PTDLYYHKENSLGETSFYCF*KI TASPCQVNKECLCQ*KFSPT*SLL*WDLRSFVTA YRLVAAVSLCPCRESRPGTACSCDSWDFILTSR CPSHVFNHGIPPPISSLSSSSTFSVSAW*ACPC LRTQNIAVLYFFVVVVTDRVRFRLPGWSAVAPSQ LTATCSLLDSSDSPASAFRVAGMTGTHQYAWVI FVFLSTYRISPCWPG*FQTPGLRWSACLSLPKC WDYRREPLGPACIFYQPQIQQQAEDSAHKTGLVS W*SHITKMLPRGEPHPPGCPPALVWAGVRACIQ YFEFVCHWFALLVRNSSALHSPGLETCYSSSWY RAN*KNQQSFHCPAKVHLSTPLPN*SGMRLALSK SIQVWLLM*LRI*EPDARSNKL*KSEEHCRKGL LSIS*VP**A*QPAVVAHACNPSTLGGQGGRMT RSGVQDQPGQHAETSPLLKIQKLAGHGGTCL*SQ LLGRLRQENRLNPGGGGCSEPRQCQCTPASVTA QGSVSIIKKKKKKKKAGRSGSSL*SQHFGRLRR ADHLRSGVLRSALATR*NPISTKNTKLAKHAGTC L*SQLLGRLRYENRLNLGGRGCSEPRSRHCTPA WGTRVNLCLTKKKKKKKDA*QRLP*ATNS*PLI LPVSSRIYS*PQ*SSPCSQTELIHSMRTVSLTSI VYAPAAPCLLLAWSQRGCAGE*QGIVGHVDISL RLC*KHLPCSVCDWERAQCFNTPQITTLIITLS PQFNSFSWILVQVR*QVDVTMPFQSLPSLSRESL QNRN*SIGRQSNLCI

Frame 2

GGAGRVLRAGAGPGYGGCRAPATAPATPTAPLR AGWAAGSRLQRWVSSGLWRAACVGWACSTWFA* MIGRWI*DPASNMWQLWASLCCLLVLANARSRP SFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYL KRLCGTFLGGPKPPQRVMFTEDLKLPASFDARE QWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRI CIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYP AEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCE HHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQ DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV YSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVE NGTPYWLVANSWNTDWGDNGFFKILRGQDHCGI ESEVVAGIPRTDQYWEKI*SAVGLSCQSWGRDRG RNAFYSLSSRKIQVSDRV*RTGLAKHQTCLPRR PSPGYIPACGYSADRPCEPPLPAQSVLPPVD*C RREYLLPQLTVAPSVIHPSPGSKTETQEWKAEFL TG*KFPHQFPQYLQASSFPHLSQKSEERRCWEP FGERQSPRPPASIEFAMSQPL*SCAQHDSLIEV LFFRALC*SCG*ASGTAGDLC*FYRLPPYDAAQK ETKWSGVVSDPLISTTTRKIV*EKPAFTVFEKL QLHPVKLTRNACANKSFLQLEVYSDGISDPLSL PIDL*LLSLFVPAENHVLELHVLATLGTSS*LLA APAMFSTMASLPQLVPCHPRQPSL*VPGKLALA *ELKT*LCSIFLLLL*LTE*DSVSQAGVQWRLL SSLQPAAS*IQAILLLQPSE*LG*QALTNMPG*F LYF*VHTGFHHVGQASFKLPASGGLPASASQSV GITGVSHWALPVFFISHKSSNKLRIQLIKQAWC LGDLT*PRCYPVGNHIPLDALQPWFGLESGPVYS ILNLYATGLHCWSGTLVLCIALV*KHVIAVLGI EQTRRTSNHSTVLPRYTSVLPFPTEVV*G*LFP KAFKFGF*CDSEFRNQMLDQISSENLRNIVGKVC *ASLKCHDEHNSRPSWLTPVIPALWEAKVGG*Q GQEFKTSLANMLKPHLY*KYKN*LGMVAHACNP SYLGG*GRRIA*TREAEVAVSQDSASALQPR*QR KAPSQ*LKKKKKKKRPGAVAQACNPSTLGG*GG QIT*GQEF*DQPWQHGETPSLLKIQN*PSMLAH ACNPSYSGG*GTRIA*TWEAEDAVSRDHAIALQP GGQE*ICVSPKKKRKRKMLNKGYHKPQIHNHLS FQFQVEYIHNLNKVLPAPKLS*FIPCALSPSPP SYTHLQLLACF*HGASGDVLVSDKELWGMSTSA* GFVRNTCLAVFVTGKELSVLIHLRSPH*S*LCH LSSIVSPGFLSK*DDRWT*QCLFSLYLASPENH SRIEIRV*VGSPTSAF

Sequence CTSB.bAug05

GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCG CGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCT GGTTCCCACCTCAGCCTCCCGAGTAGTGTCTTCAGGCCTATGGAGAGCAGCTTGCGTGGGCTGGGCCTGCAGTACCTGGTTTGCATAGATGATTGGCAGG TGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCC TGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATG TGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATGTTTACCGAGGACCTGAAGCTGCCTGCAAGCTTCGATGCACGGGAACAATGGCCACAG TGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCTCCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGGATCTGCATCCACACCA ATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCACATGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCCTGCTGAAGCTTG GAACTTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTATGAATCCCATGTAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAGCACCACGTCAAC GGCTCCCGGCCCCCATGCACGGGGGAGGGAGATACCCCCAAGTGTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGGACAAGCACTACG GATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTT CCTGCTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCC TACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGG TGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCATT TTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGC TACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTACC TGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAA GTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAACGC CAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTG CACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTG GTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCT GTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACTTGT AGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCAT GTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCAAA ACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCAGCTCACTGCAAC CTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATTTTTGTATTTTTA AGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGC GTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAATCCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTCTTGGTGATCTCA CATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGATGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTT GTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTTTGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGA AGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCTCAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCAAGT TTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTGTTAAGCATCTCT TAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAAGGTCAGGAGTTC AAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAG GCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCGCAAGGCTCCGTC TCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGA GGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATGCCTGTAATCCCA GCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGA GTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATGCTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAA GTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCAAACTGAGTTGATTCATTCCATGCGCACTGTCTCCCTCACCTCCATCGTATACGCACC TGCAGCTCCTTGCCTGCTTCTAGCATGGAGCCAGCGGGGATGTGCTGGTGAGTGACAAGGAATTGTGGGGCATGTCGACATCAGCTTAAGGCTTTGTTAG AAACACCTGCCTTGCAGTGTTTGTGACTGGGAAAGAGCTCAGTGTTTTAATACACCTCAGATCACCACATTGATCATAACTTTGTCACCTCAGTTCAATA GTTTCTCCTGGATTCTTGTCCAAGTGAGATGACAGGTGGACGTAACAATGCCTTTTCAGTCTTTACCTAGCCTCTCCAGAGAATCACTCCAGAATAGAAA TTAGAGTATAGGTAGGCAGTCCAACCTCTGCATTT

CTSB.F2 (forward primer)
CTSB.R6 (reverse primer)
Single exon skipping

Frame 0

GAGPGGYLGPGLAQATAAAGLRQPLRQRQPLRC AQAGLQALGCSAGLVCSGATTAHGSLSHPDVSDL VPTSASRVVSSGLWRAACVGWACSTWFA*MIGR WI*DPASNMWQLWASLCCLLVLANARSRPSFHP LSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLC GTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQ CPTIKEIRDQGSCGSCWAFGAVEAISDRICIHT NAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAW NFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHY GYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDF LLYKSGVYQHVTGEMMGGHAIRILGWGVENGTP YWLVANSWNTDWGDNGFFKILRGQDHCGIESEV VAGIPRTDQYWEKI*SAVGLSCQSWGRDRGRNAF YSLSSRKIQVSDRV*RTGLAKHQTCLPRRPSPG YIPACGYSADRPCEPPLPAQSVLPPVD*CRREY LLPQLTVAPSVIHPSPGSKTETQEWKAEFLTG*K FPHQFPQYLQASSFPHLSQKSEERRCWEPFGER QSPRPPASIEFAMSQPL*SCAQHDSLIEVLFFR ALC*SCG*ASGTAGDLC*FYRLPPYDAAQKETKW SGVVSDPLISTTTRKIV*EKPAFTVFEKLQLHP VKLTRNACANKSFLQLEVYSDGISDPLSLPIDL *LLSLFVPAENHVLELHVLATLGTSS*LLAAPAM FSTMASLPQLVPCHPRQPSL*VPGKLALA*ELK T*LCSIFLLLL*LTE*DSVSQAGVQWRLLSSLQ PAAS*IQAILLLQPSE*LG*QALTNMPG*FLYF* VHTGFHHVGQASFKLPASGGLPASASQSVGITG VSHWALPVFFISHKSSNKLRIQLIKQAWCLGDL T*PRCYPVGNHIPLDALQPWFGLESGPVYSILNL YATGLHCWSGTLVLCIALV*KHVIAVLGIEQTR RTSNHSTVLPRYTSVLPFPTEVV*G*LFPKAFK FGF*CDSEFRNQMLDQISSENLRNIVGKVC*ASL KCHDEHNSRPSWLTPVIPALWEAKVGG*QGQEF KTSLANMLKPHLY*KYKN*LGMVAHACNPSYLG G*GRRIA*TREAEVAVSQDSASALQPR*QRKAPS Q*LKKKKKKKRPGAVAQACNPSTLGG*GGQIT* GQEF*DQPWQHGETPSLLKIQN*PSMLAHACNP SYSGG*GTRIA*TWEAEDAVSRDHAIALQPGGQE *ICVSPKKKRKRKMLNKGYHKPQIHNHLSFQFQ VEYIHNLNKVLPAPKLS*FIPCALSPSPPSYTH LQLLACF*HGASGDVLVSDKELWGMSTSA*GFVR NTCLAVFVTGKELSVLIHLRSPH*S*LCHLSSI VSPGFLSK*DDRWT*QCLFSLYLASPENHSRIE IRV*VGSPTSAF

Frame 1

GRGREGT*GRGWPRLRRLQGSGNRSGNANRSAA RRLGCRLSAAALGWCAVVRPRLTAASATQM*AI WFPPQPPE*CLQAYGEQLAWAGPAVPGLHR*LAG GSRIRLPTCGSSGPPSAACWCWPMPGAGPLSIP CRMSWSTMSTNGIPRGRPGTTSTTWT*AT*RGY VVPSWVGPSHPRELCLPRT*SCLQASMHGNNGHS VPPSKRSETRAPVAPAGPSGLWKPSLTGSASTP MRTSAWRCRRRTCSHAVAACVGTAVMVAILLKL GTSGQEKAWFLVASMNPM*GADRTPSLPVSTTST APGPHARGREIPPSVARSVSLATARPTNRTSTT DTIPTASPIARRTSWPRSTKTAPWRELSLCIRT SCSTSQECTNTSPER*WVAMPSASWAGEWRMAHP TGWLPTPGTLTGVTMASLKYSEDRITVESNQKW WLEFHAPISTGKRSNLPWACRASPGGEIGVEMH FIL*VHVRYKFQTGSEGLDWPNIRPVFQGDQVLA TSQPVVTVQTGHVSHRCQHRASFPL*TSAVGST CCPS*LWPPP*SIHLQGARQRRRNGKRSS*QDE SSPISSPSTSKQVAFHICHRNQRRDGVGSPLENA SLPGPLHLSSLQCHNLSDLVLSMIL**KFYFFV HSANHVGEPVEQRETCASFTDCLLMTRLKRKPS GQELFLTH*SLLPQGK*FRRNQLLLFLKNYSFTL SS*QGMPVPIKVFSNLKSTLMGSQILCHCL*TC SCCLSLSLQRITSWNCMFLRLLGLHLNFSLPQP CFQPWHPSPN*FPVILVNLLCKCLVSLPLLKNSK HSCALFFCCCCD*QSEIPSPRLECSGAFSAHCN LQPPRFKRFSCFSLPSSWDDRHSPICLGNFCIF KYIQDFTMLARLVSNSRPQVVCLPQPPKVLGLQA *ATGPCLYFLSATNPATS*GFSS*NRLGVLVIS HNQDATPWGTTSPWMPSSLGLGWSQGLYTVF*I CMPLVCIAGQEL*CFA*PWFRNML*QFLV*SKLE EPAIIPLSCQGTPQYSPSQLKWYEASSFQKHSS LASDVTQNLGTRC*IK*ALKI*GTL*ERFVKHL LSAMMSITAGRRGSRL*SQHFGRPRWEDDKVRSS RPAWPTC*NLTSTKNTKISWAWWHMPVIPATWE AEAGESLEPGRRRLQ*AKTVPVHSSLGDSARLR LNN*KKKKKKKGRAQWLKPVIPALWEAEAGRSPE VRSFEISLGNTVKPHLY*KYKISQACWHMPVIP ATREAEVRESLEPGRQRMQ*AEITPLHSSLGDK SESVSHQKKKEKERCLTKVTISHKFITTYPSSFK *NIFITSIKFSLLPN*VDSFHAHCLPHLHRIRT CSSLPASSMEPAGMCW*VTRNCGACRHQLKALL ETPALQCL*LGKSSVF*YTSDHHIDHNFVTSVQ* FLLDSCPSEMTGGRNNAFSVFT*PLQRITPE*K LEYR*AVQPLH

Frame 2

GGAGRVLRAGAGPGYGGCRAPATAPATPTAPLR AGWAAGSRLQRWAGVQWCDHGSRQPQPPRCKRS GSHLSLPSSVFRPMESSLRGLGLQYLVCIDDWQ VDLGSGFQHVAALGLPLLPAGVGQCPEQALFPSP VG*AGQLCQQTEYHVAGRAQLLQRGHELLEEAM WYLPGWAQATPESYVYRGPEAACKLRCTGTMAT VSHHQRDQRPGLLWLLLGLRGCGSHL*PDLHPHQ CARQRGGVGGGPAHMLWQHVWGRL*WWLSC*SL ELLDKKRPGFWWPL*IPCRVQTVLHPSL*APRQ RLPAPMHGGGRYPQV*QDL*AWLQPDLQTGQALR IQFLQRLQ*REGHHGRDLQKRPRGGSFLCVFGL PALQVRSVPTRHRRDDGWPCHPHPGLGSGEWHT LLAGCQLLEH*LG*QWLL*NTQRTGSLWNRIRSG GWNSTHRSVLGKDLICRGPVVPVLGARSG*KCI LFFKFT*DTSFRQGLKDWIGQTSDLSSKETKSW LHPSLWLQCRQAM*ATAASTERPSPCRLVP*GVP AAPADCGPLRDPSISREQDRDAGMESGVPNRMK VPPSVPPVPPSK*LSTFVTEIRGETVLGALWRT PVSQAPCIYRVCNVTTSLILCSA*FFNRSFIFSC TLLIMWVSQWNSGRPVLVLQIASL*RGSKGNQV VRSCF*PTDLYYHKENSLGETSFYCF*KITASP CQVNKECLCQ*KFSPT*SLL*WDLRSFVTAYRLV AAVSLCPCRESRPGTACSCDSWDFILTSRCPSH VFNHGIPPPISSLSSSSTFSVSAW*ACPCLRTQ NIAVLYFFVVVVTDRVRFRLPGWSAVAPSQLTAT CSLLDSSDSPASAFRVAGMTGTHQYAWVIFVFL STYRISPCWPG*FQTPGLRWSACLSLPKCWDYR REPLGPACIFYQPQIQQQAEDSAHKTGLVSW*SH ITKMLPRGEPHPPGCPPALVWAGVRACIQYFEF VCHWFALLVRNSSALHSPGLETCYSSSWYRAN* KNQQSFHCPAKVHLSTPLPN*SGMRLALSKSIQV WLLM*LRI*EPDARSNKL*KSEEHCRKGLLSIS *VP**A*QPAVVAHACNPSTLGGQGGRMTRSGV QDQPGQHAETSPLLKIQKLAGHGGTCL*SQLLGR LRQENRLNPGGGGCSEPRQCQCTPASVTAQGSV SIIKKKKKKKKAGRSGSSL*SQHFGRLRRADHL RSGVLRSALATR*NPISTKNTKLAKHAGTCL*SQ LLGRLRYENRLNLGGRGCSEPRSRHCTPAWGTR VNLCLTKKKKKKKDA*QRLP*ATNS*PLILPVS SRIYS*PQ*SSPCSQTELIHSMRTVSLTSIVYAP AAPCLLLAWSQRGCAGE*QGIVGHVDISLRLC* KHLPCSVCDWERAQCFNTPQITTLIITLSPQFN SFSWILVQVR*QVDVTMPFQSLPSLSRESLQNRN *SIGRQSNLCI