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Sequences

Sequence DDR1.nAug05

ATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCC CCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGAT

DDR1.F1 (forward primer)
DDR1.R1 (reverse primer)
Multiple exon skipping

Frame 0

ILLLLLIIALMLWRLHWRRLLSKVLESHPRTRS PGLVGIRPTPLPVSPMALVHLCEVDSPQD

Frame 1

SCSCCSSLPSCSGGCTGAGSSARS*RATPVPGA PASWESAPLRSLCPQWLWCTCVRSTALK

Frame 2

PAPAAHHCPHALAAALAQAPQQGPREPPPYQEP RPRGNPPHSAPCVPNGSGAPV*GRQPSR

Sequence DDR1.mAug05

ATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAACGGAGGGTGTTGGAAGAGGAGCTGA CGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCGGCCTCGTGGGAATCC GCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGAT

DDR1.F1 (forward primer)
DDR1.R1 (reverse primer)
Multiple exon skipping

Frame 0

ILLLLLIIALMLWRLHWRRLLSKAERRVLEEEL TVHLSVPGDTILINNRPGPREPPPYQEPRPRGNP PHSAPCVPNGSGAPV*GRQPSR

Frame 1

SCSCCSSLPSCSGGCTGAGSSARLNGGCWKRS* RFTSLSLGTLSSSTTAQVLESHPRTRSPGLVGI RPTPLPVSPMALVHLCEVDSPQD

Frame 2

PAPAAHHCPHALAAALAQAPQQG*TEGVGRGAD GSPLCPWGHYPHQQPPRS*RATPVPGAPASWES APLRSLCPQWLWCTCVRSTALK

Sequence DDR1.dAug05

GCCCCAGCCCTGGCTCCTCTCCCCGGAACAGGCCCCCGACAGCTGCTCTCGGGAGCCGCCTCCCGACACCCGAGCCCCGCCGGCGCCTCCCGCTCCCGGC TCCCGGCTCCTGGCTCCCTCCGCCTCCCCCGCCCCTCGCCCCGCCGCCGAAGAGGCCCCGCTCCCGGGTCGGACGCCTGGGTCTGCCGGGAAGAGCGATG AGAGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGA GATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCT CCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGA GTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTAC CGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGC TGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTG CCTCTGGAGGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACAT ACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAG GCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGT CCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATG CGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCT TTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTG GTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATC CTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAAC GGAGGGTGTTGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCA GGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCGTTGCTGCTCTCCAATCCAGCCTACCGCCTCCTTCTGGCC ACTTACGCCCGTCCCCCTCGAGGCCCGGGCCCCCCCACACCCGCCTGGGCCAAACCCACCAACACCCAGGCCTACAGTGGGGACTATATGGAGCCTGAGA AGCCAGGCGCCCCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACAC CTATGCTGTGCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAG GGCCAGTTTGGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGG TAGCTGTCAAGATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCAT TCGGCTGCTGGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTG GAGGACAAGGCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCT CCGGCATGCGCTATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTT TGGCATGAGCCGGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGG AAGTTCACGACTGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGC AGGTCATCGAGAACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCT TCGGTGCTGGAGCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCA GCTGCCCCTCCCTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACC TCTAATAGAGGCAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTC TTCCTTCCTAGAAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATA TAGGATAGACACTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGT CACACACTGGACCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTG GGCTTCTTCCTCCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAA CTTCTCTAAGCCTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGC TGCCACATTGATTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTT TAATCCCCTGCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCC TCTGAACCCACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTG GATAATCCAGGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAA GGAATGCAGTCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAA AACCTATAAAATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCA ACCTGGCCAACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGG CAGGAGAATTGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAAC AGAACAACAACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTG CTTCTTTTTCATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F1 (forward primer)
DDR1.R1 (reverse primer)
Multiple exon skipping

Frame 0

APALAPLPGTGPRQLLSGAASRHPSPAGASRSR LPAPGSLRLPRPSPRRRRGPAPGSDAWVCREER* ERCCPHPLRPEGSGAMGPEALSSLLLLLLVASG DADMKGHFDPAKCRYALGMQDRTIPDSDISASS SWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEE YLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSY RLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVV LKDLGPPMVARLVRFYPRADRVMSVCLRVELYGC LWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGH TVGGLQYGGLGQLADGVVGLDDFRKSQELRVWP GYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQV HCNNMHTLGARLPGGVECRFRRGPAMAWEGEPM RHNLGGNLGDPRARAVSVPLGGRVARFLQCRFL FAGPWLLFSEISFISDVVNNSSPALGGTFPPAPW WPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAE RRVLEEELTVHLSVPGDTILINNRPGPREPPPYQ EPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLA TYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPE KPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNT YAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGE GQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLL VAVKILRPDATKNARNDFLKEVKIMSRLKDPNII RLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIA SGMRYLATLNFVHRDLATRNCLVGENFTIKIADF GMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG KFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDE QVIENAGEFFRDQGRQVYLSRPPACPQGLYELML RCWSRESEQRPPFSQLHRFLAEDALNTV*ITHP AAPPSGSDPGEASDTKTRGHNGTSALPLPTAHH L**RQ*DCRWAGPTQGADAPSPLPGHTLMSPSCS SFLEAPVAHPAGPVDGILSTLL*PSLGEGWGEI *DRHWTWPIGAPGPHWTTLIPGEVAAPPASLSL SHTGPHWLRIWG*GGQEGEENVSLCLLLYLSSAW ASSSSIT*NTGPGGSPAPALSHPHFPLAVL*LE LL*AYTFLWSKYWDWGERGSNGP*PWGWTSLV* LPH*FFYNHLGFVHFWGERHRFLH*YMDLA*GNF NPLH*AGNNKG*VFHNCVSGFLGNLVTLPPAPP SEPTSQPTSHLPFFLPPHSISHHLFCPALCSVS G*SRPLPVGPQEMHECLSA*TFSTQRGALVEAWK ECSQARGAEPFLCHKRLWQSVEVY*VLLRIRF* NL*NGPGIVAHPCNPSTLGG*GG*IT*GQEFET NLANIAKPHLY*RYKN*QGVVACACNLSYSGG*G RRIA*NPGGGGCSELRSHNCAPAWATE*DCLKN RTTTTTKPIKCIGL*GKPMETVYQNAKKL*N*C ASFSCI**QDLKTGVIN*HFPNT

Frame 1

PQPWLLSPEQAPDSCSREPPPDTRAPPAPPAPG SRLLAPSASPAPRPAAEEAPLPGRTPGSAGKSD ERDAAPTPLGPRDQELWDQRPCHLYCCCSWWQVE MLT*RDILILPSAAMPWACRTGPSQTVTSLLPA PGQIPLPPATAGWRAVTGMGPGAPQGRCFPRRR STCRWIYNDCTWWLWWAPRDGMPGAWARSSPGAT GCVTPGMVAAGWAGRTAGVRR*SQAMRTLREWC *RTLGPPWLPDWFASTPGLTGS*ASVCG*SSMA ASGGMDSCLTPPLWGRQCIYLRPCTSTTPPMTDI PWADCSMGVWASWQMVWWGWMTLGRVRSCGSGQ AMTMWDGATTASPVAMWRWSLSLTG*GPSRLCR STVTTCTRWEPVCLAGWNVASGVALPWPGRGSPC ATT*GATWGTPEPGLSQCPLAAVWLAFCSAASS LRGPGYSSAKSPSSLMW*TIPLRHWEAPSRQPP GGRLAHLPPTSAAWSWSPEASSPWPRPRGARPPS SSAAWWPSSCSCCSSLPSCSGGCTGAGSSARLN GGCWKRS*RFTSLSLGTLSSSTTAQVLESHPRT RSPGLVGIRPTPLPVSPMALRCCSPIQPTASFWP LTPVPLEARAPPHPPGPNPPTPRPTVGTIWSLR SQAPRFCPHLPRTASPIMPRLTLLPCRASPGAT PMLCLHCPQGQSGMGPPEWISLDLDSASRRSLAR ASLGRCTCVRSTALKIWLVLISPLMCVRDTLCW *LSRSYGQMPPRMPGMIS*KR*RSCRGSRTQTS FGCWACVCRTTPSA*LLTTWRTATSTSSSVPTSW RTRQPRGPLGTGRLRRGPPSATQCCCMWQPRSP PACAIWPHSTLYIGTWPRGTA*LGKISPSKSQT LA*AGTSMLGTITVCRAGQCCPSAGWPGSASSWG SSRLRVTCGPLV*PCGRC*CSVGPSPLGSSPTS RSSRTRGSSSGTRAGRCTCPGRLPARRAYMS*C FGAGAGSLSSDHPFPSCIGSWQRMHSTRCESHIQ LPLPQGAIQGKPVTLKQEDTMAPLPFPSRQPIT SNRGSETAGGLGPPRELMPLLPFLDTLSCPLPV LPS*KPLSPTQLVLWMGSSPPSSSHPLGKGGEKY RIDTGHGPLEHLGPTGQH*FLERWLRPQLLSPC HTLDPTG*ESGGEEDKKERKMFPCACSCTCPQL GLLPPPSPETLDLGVAPPQPSVTPTSHLQSCS*N FSKPIRFCGVNIGIGGKEGATAHSLGVGHL*CS CHIDFSIITWGLYIFGGRDTDFYTNIWT*LEAI LIPCTRQVIIKVEFSTTV*VGSLGIW*LCLLHLP LNPLPNPLPIFLFSCLLIPFPITCFAQHCVLFL DNPGLCLWDLRRCMNV*VHEPSQLRGVLWWRPG RNAVRPGVLNLFCAINAFGSL*RSTESSSELGFK TYKMDQA*WLTPVIPALWEAEVGRSLEARSSRP TWPT*QNPISTKDTKISRVWWHAPVISAIQEAE AGELLRTREVGVAVS*DHTTVLQPGQQSETVSKT EQQQQQNP*NV*DYKGNQWKQFTKMLKNYETNV LLFHVFNNKI*KQV**TDIFQIL

Frame 2

PSPGSSPRNRPPTAALGSRLPTPEPRRRLPLPA PGSWLPPPPPPLAPPPKRPRSRVGRLGLPGRAM REMLPPPP*ARGIRSYGTRGPVIFTAAALGGKW RC*HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQL LVRFHCRPPQQVGEQ*RGWGLVPRRVGVSQGGG VLAGGSTTTAPGGSGGHPGTACRGPGQGVLPEL PAALLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGA EGPWAPHGCPTGSLLPPG*PGHERLSAGRALWL PLEGWTPVLHRPCGADNVFI*GRVPQRLHL*RT YRGRTAVWGSGPAGRWCGGAG*L*EESGAAGLAR L*LCGMEQPQLLQWLCGDGV*V*PAEGLPGYAG PL*QHAHAGSPSAWRGGMSLPAWPCHGLGGGAH APQPRGQPGGPQSPGCLSAPWRPCGSLSAVPLPL CGALVTLQRNLLHL*CGEQFLSGTGRHLPASPL VAAWPTSHQLQQLGAGAQRPAARGQGRGEPDRH PHRLPGGHHPAPAAHHCPHALAAALAQAPQQG*T EGVGRGADGSPLCPWGHYPHQQPPRS*RATPVP GAPASWESAPLRSLCPQWLCVAALQSSLPPPSG HLRPSPSRPGPPHTRLGQTHQHPGLQWGLYGA*E ARRPASAPTSPEQRPPLCRG*HCYPAGRHRGQH LCCACTAPRGSRGWAPQSGFPSISTPLQGEAWR GPVWGGAPV*GRQPSRSG*S*FPP*CA*GTPFAG SCQDLTARCHQECQE*FPERGEDHVEAQGPKHH SAAGRVCAGRPPLHDY*LHGERRPQPVPQCPPA GGQGSRGGPWGRAGCAGAHHQLPNAAACGSPDRL RHALSGHTQLCTSGPGHAELPSWGKFHHQNRRL WHEPEPLCWGLLPCAGPGSAAHPLDGLGVHPHG EVHDCE*RVGLWCDPVGGADAL*GPALWAAHRRA GHRERGGVLPGPGPAGVPVPAACLPAGPI*ADA SVLEPGV*AATTLFPAASVPGRGCTQHGVNHTS SCPSLRERSRGSQ*H*NKRTQWHLCPSPPDSPSP LIEAVRLQVGWAHPGS*CPFSPSWTHSHVPFLF FLPRSPCRPPSWSCGWDPLHPPLAIPWGRVGRN IG*TLDMAHWSTWAPLDNTDSWRGGCAPSFSLPV THWTPLAENLGVRRTRRRGKCFLVPAPVLVLSL GFFLLHHLKHWTWG*PRPSPQSPPLPTCSLVAR TSLSLYVSVE*ILGLGGKREQRPIALGLDISSVA ATLIFL*SLGVCTFLGGETQIFTLIYGPSLRQF *SPALGR***RLSFPQLCEWVPWEFGNSASCTS L*THFPTHFPSSFFPASSFHFPSPVLPSIVFCFW IIQAFACGTSGDA*MSECMNLLNSEGCSGGGLE GMQSGQGC*TFFVP*TPLAVCRGLLSPPQN*VL KPIKWTRHSGSPL*SQHFGRLRWVDHLRPGVRDQ PGQHSKTPSLLKIQKLAGCGGMRL*SQLFRRLR QENCLEPGRWGLQ*AEITQLCSSLGNRVRLSQK QNNNNNKTHKMYRIIRETNGNSLPKC*KIMKLMC FFFMYLITRSKNRCNKLTFSKY

Sequence DDR1.cAug05

GGGAGCCACTGGGACTACTGGGTCCGGGAGGGGGAAGGGAGGGCTGCGAGCCCGAACGCGCGGCGAGAAGGCCGAGCGGGAGGAGGAAGGGAGGGAGCCG AGGCGAGGGGGAGGCGGCGCCTGGGCCCGAGCCGCCCCAGCCCTGGCTCCTCTCCCCGGAACAGGCCCCCGACAGCTGCTCTCGGGAGCCGCCTCCCGAC ACCCGAGCCCCGCCGGCGCCTCCCGCTCCCGGCTCCCGGCTCCTGGCTCCCTCCGCCTCCCCCGCCCCTCGCCCCGCCGCCGAAGAGGCCCCGCTCCCGG GTCGGACGCCTGGGTCTGCCGGGAAGAGCGATGAGAGGTGTCTGAAGGTGGCTATTCACTGAGCGATGGGGTTGGACTTGAAGGAATGCCAAGAGATGCT GCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGACAT GAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAGAT TCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCAGG TGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGTTA CTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACCTT GGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAGGG ATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGCGG ACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACTAT GTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAACA ACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAACCT AGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGCCC TGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCCTG GCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGCTG CCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAACGGAGGGTGTTG GAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCGGC CTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCGTTGCTGCTCTCCAATCCAGCCTACCGCCTCCTTCTGGCCACTTACGCCCG TCCCCCTCGAGGCCCGGGCCCCCCCACACCCGCCTGGGCCAAACCCACCAACACCCAGGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCGCC CCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGTGC CTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGG GGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAG ATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGG GCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGC AGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGC TATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGGCATGAGCC GGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAGTTCACGAC TGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGGTCATCGAG AACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCGGTGCTGGA GCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCTGCCCCTCC CTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCTAATAGAGG CAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTCCTTCCTAG AAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAGGATAGACA CTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCACACACTGGA CCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGCTTCTTCCT CCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTTCTCTAAGC CTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGCCACATTGA TTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGC ACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCAC TTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGG CCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTC AGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAA TGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAAC ATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTG CTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAAC AACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCA TGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F1 (forward primer)
DDR1.R1 (reverse primer)
Multiple exon skipping

Frame 0

GSHWDYWVREGEGRAASPNARREGRAGGGREGA EARGRRRLGPSRPSPGSSPRNRPPTAALGSRLPT PEPRRRLPLPAPGSWLPPPPPPLAPPPKRPRSR VGRLGLPGRAMRGV*RWLFTERWGWT*RNAKRC CPHPLRPEGSGAMGPEALSSLLLLLLVASGDADM KGHFDPAKCRYALGMQDRTIPDSDISASSSWSD STAARHSRLESSDGDGAWCPAGSVFPKEEEYLQ VDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRY SRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDL GPPMVARLVRFYPRADRVMSVCLRVELYGCLWR DGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGG LQYGGLGQLADGVVGLDDFRKSQELRVWPGYDY VGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCN NMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNL GGNLGDPRARAVSVPLGGRVARFLQCRFLFAGP WLLFSEISFISDVVNNSSPALGGTFPPAPWWPP GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGC LVAIILLLLLIIALMLWRLHWRRLLSKAERRVL EEELTVHLSVPGDTILINNRPGPREPPPYQEPR PRGNPPHSAPCVPNGSALLLSNPAYRLLLATYAR PPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGA PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAV PALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFG EVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVK ILRPDATKNARNDFLKEVKIMSRLKDPNIIRLL GVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMR YLATLNFVHRDLATRNCLVGENFTIKIADFGMS RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT ASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIE NAGEFFRDQGRQVYLSRPPACPQGLYELMLRCW SRESEQRPPFSQLHRFLAEDALNTV*ITHPAAPP SGSDPGEASDTKTRGHNGTSALPLPTAHHL**R Q*DCRWAGPTQGADAPSPLPGHTLMSPSCSSFL EAPVAHPAGPVDGILSTLL*PSLGEGWGEI*DRH WTWPIGAPGPHWTTLIPGEVAAPPASLSLSHTG PHWLRIWG*GGQEGEENVSLCLLLYLSSAWASS SSIT*NTGPGGSPAPALSHPHFPLAVL*LELL*A YTFLWSKYWDWGERGSNGP*PWGWTSLV*LPH* FFYNHLGFVHFWGERHRFLH*YMDLA*GNFNPL H*AGNNKG*VFHNCVSGFLGNLVTLPPAPPSEPT SQPTSHLPFFLPPHSISHHLFCPALCSVSG*SR PLPVGPQEMHECLSA*TFSTQRGALVEAWKECS QARGAEPFLCHKRLWQSVEVY*VLLRIRF*NL*N GPGIVAHPCNPSTLGG*GG*IT*GQEFETNLAN IAKPHLY*RYKN*QGVVACACNLSYSGG*GRRI A*NPGGGGCSELRSHNCAPAWATE*DCLKNRTTT TTKPIKCIGL*GKPMETVYQNAKKL*N*CASFS CI**QDLKTGVIN*HFPNT

Frame 1

GATGTTGSGRGKGGLRARTRGEKAEREEEGREP RRGGGGAWARAAPALAPLPGTGPRQLLSGAASR HPSPAGASRSRLPAPGSLRLPRPSPRRRRGPAPG SDAWVCREER*EVSEGGYSLSDGVGLEGMPRDA APTPLGPRDQELWDQRPCHLYCCCSWWQVEMLT *RDILILPSAAMPWACRTGPSQTVTSLLPAPGQI PLPPATAGWRAVTGMGPGAPQGRCFPRRRSTCR WIYNDCTWWLWWAPRDGMPGAWARSSPGATGCV TPGMVAAGWAGRTAGVRR*SQAMRTLREWC*RTL GPPWLPDWFASTPGLTGS*ASVCG*SSMAASGG MDSCLTPPLWGRQCIYLRPCTSTTPPMTDIPWA DCSMGVWASWQMVWWGWMTLGRVRSCGSGQAMTM WDGATTASPVAMWRWSLSLTG*GPSRLCRSTVT TCTRWEPVCLAGWNVASGVALPWPGRGSPCATT *GATWGTPEPGLSQCPLAAVWLAFCSAASSLRGP GYSSAKSPSSLMW*TIPLRHWEAPSRQPPGGRL AHLPPTSAAWSWSPEASSPWPRPRGARPPSSSA AWWPSSCSCCSSLPSCSGGCTGAGSSARLNGGCW KRS*RFTSLSLGTLSSSTTAQVLESHPRTRSPG LVGIRPTPLPVSPMALRCCSPIQPTASFWPLTP VPLEARAPPHPPGPNPPTPRPTVGTIWSLRSQAP RFCPHLPRTASPIMPRLTLLPCRASPGATPMLC LHCPQGQSGMGPPEWISLDLDSASRRSLARASL GRCTCVRSTALKIWLVLISPLMCVRDTLCW*LSR SYGQMPPRMPGMIS*KR*RSCRGSRTQTSFGCW ACVCRTTPSA*LLTTWRTATSTSSSVPTSWRTR QPRGPLGTGRLRRGPPSATQCCCMWQPRSPPACA IWPHSTLYIGTWPRGTA*LGKISPSKSQTLA*A GTSMLGTITVCRAGQCCPSAGWPGSASSWGSSR LRVTCGPLV*PCGRC*CSVGPSPLGSSPTSRSSR TRGSSSGTRAGRCTCPGRLPARRAYMS*CFGAG AGSLSSDHPFPSCIGSWQRMHSTRCESHIQLPL PQGAIQGKPVTLKQEDTMAPLPFPSRQPITSNRG SETAGGLGPPRELMPLLPFLDTLSCPLPVLPS* KPLSPTQLVLWMGSSPPSSSHPLGKGGEKYRID TGHGPLEHLGPTGQH*FLERWLRPQLLSPCHTLD PTG*ESGGEEDKKERKMFPCACSCTCPQLGLLP PPSPETLDLGVAPPQPSVTPTSHLQSCS*NFSK PIRFCGVNIGIGGKEGATAHSLGVGHL*CSCHID FSIITWGLYIFGGRDTDFYTNIWT*LEAILIPC TRQVIIKVEFSTTV*VGSLGIW*LCLLHLPLNP LPNPLPIFLFSCLLIPFPITCFAQHCVLFLDNPG LCLWDLRRCMNV*VHEPSQLRGVLWWRPGRNAV RPGVLNLFCAINAFGSL*RSTESSSELGFKTYK MDQA*WLTPVIPALWEAEVGRSLEARSSRPTWPT *QNPISTKDTKISRVWWHAPVISAIQEAEAGEL LRTREVGVAVS*DHTTVLQPGQQSETVSKTEQQ QQQNP*NV*DYKGNQWKQFTKMLKNYETNVLLFH VFNNKI*KQV**TDIFQIL

Frame 2

EPLGLLGPGGGREGCEPERAARRPSGRRKGGSR GEGEAAPGPEPPQPWLLSPEQAPDSCSREPPPD TRAPPAPPAPGSRLLAPSASPAPRPAAEEAPLP GRTPGSAGKSDERCLKVAIH*AMGLDLKECQEML PPPP*ARGIRSYGTRGPVIFTAAALGGKWRC*H EGTF*SCQVPLCPGHAGPDHPRQ*HLCFQLLVR FHCRPPQQVGEQ*RGWGLVPRRVGVSQGGGVLAG GSTTTAPGGSGGHPGTACRGPGQGVLPELPAAL LPGWSPLDGLEGPLGSGGDLRQ*GP*GSGAEGP WAPHGCPTGSLLPPG*PGHERLSAGRALWLPLEG WTPVLHRPCGADNVFI*GRVPQRLHL*RTYRGR TAVWGSGPAGRWCGGAG*L*EESGAAGLARL*L CGMEQPQLLQWLCGDGV*V*PAEGLPGYAGPL*Q HAHAGSPSAWRGGMSLPAWPCHGLGGGAHAPQP RGQPGGPQSPGCLSAPWRPCGSLSAVPLPLCGA LVTLQRNLLHL*CGEQFLSGTGRHLPASPLVAAW PTSHQLQQLGAGAQRPAARGQGRGEPDRHPHRL PGGHHPAPAAHHCPHALAAALAQAPQQG*TEGV GRGADGSPLCPWGHYPHQQPPRS*RATPVPGAPA SWESAPLRSLCPQWLCVAALQSSLPPPSGHLRP SPSRPGPPHTRLGQTHQHPGLQWGLYGA*EARR PASAPTSPEQRPPLCRG*HCYPAGRHRGQHLCCA CTAPRGSRGWAPQSGFPSISTPLQGEAWRGPVW GGAPV*GRQPSRSG*S*FPP*CA*GTPFAGSCQ DLTARCHQECQE*FPERGEDHVEAQGPKHHSAAG RVCAGRPPLHDY*LHGERRPQPVPQCPPAGGQG SRGGPWGRAGCAGAHHQLPNAAACGSPDRLRHA LSGHTQLCTSGPGHAELPSWGKFHHQNRRLWHEP EPLCWGLLPCAGPGSAAHPLDGLGVHPHGEVHD CE*RVGLWCDPVGGADAL*GPALWAAHRRAGHR ERGGVLPGPGPAGVPVPAACLPAGPI*ADASVLE PGV*AATTLFPAASVPGRGCTQHGVNHTSSCPS LRERSRGSQ*H*NKRTQWHLCPSPPDSPSPLIE AVRLQVGWAHPGS*CPFSPSWTHSHVPFLFFLPR SPCRPPSWSCGWDPLHPPLAIPWGRVGRNIG*T LDMAHWSTWAPLDNTDSWRGGCAPSFSLPVTHW TPLAENLGVRRTRRRGKCFLVPAPVLVLSLGFFL LHHLKHWTWG*PRPSPQSPPLPTCSLVARTSLS LYVSVE*ILGLGGKREQRPIALGLDISSVAATL IFL*SLGVCTFLGGETQIFTLIYGPSLRQF*SPA LGR***RLSFPQLCEWVPWEFGNSASCTSL*TH FPTHFPSSFFPASSFHFPSPVLPSIVFCFWIIQ AFACGTSGDA*MSECMNLLNSEGCSGGGLEGMQS GQGC*TFFVP*TPLAVCRGLLSPPQN*VLKPIK WTRHSGSPL*SQHFGRLRWVDHLRPGVRDQPGQ HSKTPSLLKIQKLAGCGGMRL*SQLFRRLRQENC LEPGRWGLQ*AEITQLCSSLGNRVRLSQKQNNN NNKTHKMYRIIRETNGNSLPKC*KIMKLMCFFF MYLITRSKNRCNKLTFSKY

Sequence DDR1.bAug05

TTAGGAAGTTATTTAACTGATCTCTGCCCTAGTTTCTTCATGTGTTAAATATGGATAGTAATAGTATCTACCTTATGAAGTGACTGTGAAGATAAAATTA TGGATTCTGTTTAAGGGTTTAGGCCAGTGTCTGGCACAGGGGAAGCATTCTAAAAATATAGCTGATGCTGTTAAACAATGACTGTTGTTGTTGTTTTACT GTTATTATCCCCAAAGCGGCCCATTCTGTCTGTTGCTGTCAGCTATGACTCAGTCCCCTGATTAACTTACGCACCACCCATTTTATCCCCTGCAGAGATG CTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGAC ATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAG ATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCA GGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGT TACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACC TTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAG GGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGC GGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACT ATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAA CAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAAC CTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGC CCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCC TGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGC TGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAACGGAGGGTGT TGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCG GCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCGTTGCTGCTCTCCAATCCAGCCTACCGCCTCCTTCTGGCCACTTACGCC CGTCCCCCTCGAGGCCCGGGCCCCCCCACACCCGCCTGGGCCAAACCCACCAACACCCAGGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCG CCCCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGT GCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTT GGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCA AGATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCT GGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAG GCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGC GCTATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGGCATGAG CCGGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAGTTCACG ACTGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGGTCATCG AGAACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCGGTGCTG GAGCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCTGCCCCT CCCTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCTAATAGA GGCAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTCCTTCCT AGAAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAGGATAGA CACTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCACACACTG GACCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGCTTCTTC CTCCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTTCTCTAA GCCTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGCCACATT GATTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCT GCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCC ACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCA GGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAG TCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAA AATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCA ACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAAT TGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACA ACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTT CATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F1 (forward primer)
DDR1.R1 (reverse primer)
Multiple exon skipping

Frame 0

LGSYLTDLCPSFFMC*IWIVIVSTL*SDCEDKI MDSV*GFRPVSGTGEAF*KYS*CC*TMTVVVVLL LLSPKRPILSVAVSYDSVP*LTYAPPILSPAEM LPPPP*ARGIRSYGTRGPVIFTAAALGGKWRC* HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQLLVR FHCRPPQQVGEQ*RGWGLVPRRVGVSQGGGVLA GGSTTTAPGGSGGHPGTACRGPGQGVLPELPAA LLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGAEGP WAPHGCPTGSLLPPG*PGHERLSAGRALWLPLE GWTPVLHRPCGADNVFI*GRVPQRLHL*RTYRG RTAVWGSGPAGRWCGGAG*L*EESGAAGLARL*L CGMEQPQLLQWLCGDGV*V*PAEGLPGYAGPL* QHAHAGSPSAWRGGMSLPAWPCHGLGGGAHAPQ PRGQPGGPQSPGCLSAPWRPCGSLSAVPLPLCGA LVTLQRNLLHL*CGEQFLSGTGRHLPASPLVAA WPTSHQLQQLGAGAQRPAARGQGRGEPDRHPHR LPGGHHPAPAAHHCPHALAAALAQAPQQG*TEGV GRGADGSPLCPWGHYPHQQPPRS*RATPVPGAP ASWESAPLRSLCPQWLCVAALQSSLPPPSGHLR PSPSRPGPPHTRLGQTHQHPGLQWGLYGA*EARR PASAPTSPEQRPPLCRG*HCYPAGRHRGQHLCC ACTAPRGSRGWAPQSGFPSISTPLQGEAWRGPV WGGAPV*GRQPSRSG*S*FPP*CA*GTPFAGSCQ DLTARCHQECQE*FPERGEDHVEAQGPKHHSAA GRVCAGRPPLHDY*LHGERRPQPVPQCPPAGGQ GSRGGPWGRAGCAGAHHQLPNAAACGSPDRLRHA LSGHTQLCTSGPGHAELPSWGKFHHQNRRLWHE PEPLCWGLLPCAGPGSAAHPLDGLGVHPHGEVH DCE*RVGLWCDPVGGADAL*GPALWAAHRRAGHR ERGGVLPGPGPAGVPVPAACLPAGPI*ADASVL EPGV*AATTLFPAASVPGRGCTQHGVNHTSSCP SLRERSRGSQ*H*NKRTQWHLCPSPPDSPSPLIE AVRLQVGWAHPGS*CPFSPSWTHSHVPFLFFLP RSPCRPPSWSCGWDPLHPPLAIPWGRVGRNIG* TLDMAHWSTWAPLDNTDSWRGGCAPSFSLPVTHW TPLAENLGVRRTRRRGKCFLVPAPVLVLSLGFF LLHHLKHWTWG*PRPSPQSPPLPTCSLVARTSL SLYVSVE*ILGLGGKREQRPIALGLDISSVAATL IFL*SLGVCTFLGGETQIFTLIYGPSLRQF*SP ALGR***RLSFPQLCEWVPWEFGNSASCTSL*T HFPTHFPSSFFPASSFHFPSPVLPSIVFCFWIIQ AFACGTSGDA*MSECMNLLNSEGCSGGGLEGMQ SGQGC*TFFVP*TPLAVCRGLLSPPQN*VLKPI KWTRHSGSPL*SQHFGRLRWVDHLRPGVRDQPGQ HSKTPSLLKIQKLAGCGGMRL*SQLFRRLRQEN CLEPGRWGLQ*AEITQLCSSLGNRVRLSQKQNN NNNKTHKMYRIIRETNGNSLPKC*KIMKLMCFFF MYLITRSKNRCNKLTFSKY

Frame 1

*EVI*LISALVSSCVKYG***YLPYEVTVKIKL WILFKGLGQCLAQGKHSKNIADAVKQ*LLLLFY CYYPQSGPFCLLLSAMTQSPD*LTHHPFYPLQRC CPHPLRPEGSGAMGPEALSSLLLLLLVASGDAD MKGHFDPAKCRYALGMQDRTIPDSDISASSSWS DSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQ VDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKD LGPPMVARLVRFYPRADRVMSVCLRVELYGCLWR DGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVG GLQYGGLGQLADGVVGLDDFRKSQELRVWPGYD YVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCN NMHTLGARLPGGVECRFRRGPAMAWEGEPMRHN LGGNLGDPRARAVSVPLGGRVARFLQCRFLFAG PWLLFSEISFISDVVNNSSPALGGTFPPAPWWPP GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIG CLVAIILLLLLIIALMLWRLHWRRLLSKAERRV LEEELTVHLSVPGDTILINNRPGPREPPPYQEPR PRGNPPHSAPCVPNGSALLLSNPAYRLLLATYA RPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPG APLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAV PALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQF GEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV KILRPDATKNARNDFLKEVKIMSRLKDPNIIRLL GVCVQDDPLCMITDYMENGDLNQFLSAHQLEDK AAEGAPGDGQAAQGPTISYPMLLHVAAQIASGM RYLATLNFVHRDLATRNCLVGENFTIKIADFGMS RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFT TASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVI ENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCW SRESEQRPPFSQLHRFLAEDALNTV*ITHPAAP PSGSDPGEASDTKTRGHNGTSALPLPTAHHL** RQ*DCRWAGPTQGADAPSPLPGHTLMSPSCSSFL EAPVAHPAGPVDGILSTLL*PSLGEGWGEI*DR HWTWPIGAPGPHWTTLIPGEVAAPPASLSLSHT GPHWLRIWG*GGQEGEENVSLCLLLYLSSAWASS SSIT*NTGPGGSPAPALSHPHFPLAVL*LELL* AYTFLWSKYWDWGERGSNGP*PWGWTSLV*LPH *FFYNHLGFVHFWGERHRFLH*YMDLA*GNFNPL H*AGNNKG*VFHNCVSGFLGNLVTLPPAPPSEP TSQPTSHLPFFLPPHSISHHLFCPALCSVSG*S RPLPVGPQEMHECLSA*TFSTQRGALVEAWKECS QARGAEPFLCHKRLWQSVEVY*VLLRIRF*NL* NGPGIVAHPCNPSTLGG*GG*IT*GQEFETNLA NIAKPHLY*RYKN*QGVVACACNLSYSGG*GRRI A*NPGGGGCSELRSHNCAPAWATE*DCLKNRTT TTTKPIKCIGL*GKPMETVYQNAKKL*N*CASF SCI**QDLKTGVIN*HFPNT

Frame 2

RKLFN*SLP*FLHVLNMDSNSIYLMK*L*R*NY GFCLRV*ASVWHRGSILKI*LMLLNNDCCCCFT VIIPKAAHSVCCCQL*LSPLINLRTTHFIPCRD AAPTPLGPRDQELWDQRPCHLYCCCSWWQVEMLT *RDILILPSAAMPWACRTGPSQTVTSLLPAPGQ IPLPPATAGWRAVTGMGPGAPQGRCFPRRRSTC RWIYNDCTWWLWWAPRDGMPGAWARSSPGATGCV TPGMVAAGWAGRTAGVRR*SQAMRTLREWC*RT LGPPWLPDWFASTPGLTGS*ASVCG*SSMAASG GMDSCLTPPLWGRQCIYLRPCTSTTPPMTDIPWA DCSMGVWASWQMVWWGWMTLGRVRSCGSGQAMT MWDGATTASPVAMWRWSLSLTG*GPSRLCRSTV TTCTRWEPVCLAGWNVASGVALPWPGRGSPCATT *GATWGTPEPGLSQCPLAAVWLAFCSAASSLRG PGYSSAKSPSSLMW*TIPLRHWEAPSRQPPGGR LAHLPPTSAAWSWSPEASSPWPRPRGARPPSSSA AWWPSSCSCCSSLPSCSGGCTGAGSSARLNGGC WKRS*RFTSLSLGTLSSSTTAQVLESHPRTRSP GLVGIRPTPLPVSPMALRCCSPIQPTASFWPLTP VPLEARAPPHPPGPNPPTPRPTVGTIWSLRSQA PRFCPHLPRTASPIMPRLTLLPCRASPGATPML CLHCPQGQSGMGPPEWISLDLDSASRRSLARASL GRCTCVRSTALKIWLVLISPLMCVRDTLCW*LS RSYGQMPPRMPGMIS*KR*RSCRGSRTQTSFGC WACVCRTTPSA*LLTTWRTATSTSSSVPTSWRTR QPRGPLGTGRLRRGPPSATQCCCMWQPRSPPAC AIWPHSTLYIGTWPRGTA*LGKISPSKSQTLA* AGTSMLGTITVCRAGQCCPSAGWPGSASSWGSSR LRVTCGPLV*PCGRC*CSVGPSPLGSSPTSRSS RTRGSSSGTRAGRCTCPGRLPARRAYMS*CFGA GAGSLSSDHPFPSCIGSWQRMHSTRCESHIQLPL PQGAIQGKPVTLKQEDTMAPLPFPSRQPITSNR GSETAGGLGPPRELMPLLPFLDTLSCPLPVLPS *KPLSPTQLVLWMGSSPPSSSHPLGKGGEKYRID TGHGPLEHLGPTGQH*FLERWLRPQLLSPCHTL DPTG*ESGGEEDKKERKMFPCACSCTCPQLGLL PPPSPETLDLGVAPPQPSVTPTSHLQSCS*NFSK PIRFCGVNIGIGGKEGATAHSLGVGHL*CSCHI DFSIITWGLYIFGGRDTDFYTNIWT*LEAILIP CTRQVIIKVEFSTTV*VGSLGIW*LCLLHLPLNP LPNPLPIFLFSCLLIPFPITCFAQHCVLFLDNP GLCLWDLRRCMNV*VHEPSQLRGVLWWRPGRNA VRPGVLNLFCAINAFGSL*RSTESSSELGFKTYK MDQA*WLTPVIPALWEAEVGRSLEARSSRPTWP T*QNPISTKDTKISRVWWHAPVISAIQEAEAGE LLRTREVGVAVS*DHTTVLQPGQQSETVSKTEQQ QQQNP*NV*DYKGNQWKQFTKMLKNYETNVLLF HVFNNKI*KQV**TDIFQIL

Sequence DDR1.aAug05

TTAGGAAGTTATTTAACTGATCTCTGCCCTAGTTTCTTCATGTGTTAAATATGGATAGTAATAGTATCTACCTTATGAAGTGACTGTGAAGATAAAATTA TGGATTCTGTTTAAGGGTTTAGGCCAGTGTCTGGCACAGGGGAAGCATTCTAAAAATATAGCTGATGCTGTTAAACAATGACTGTTGTTGTTGTTTTACT GTTATTATCCCCAAAGCGGCCCATTCTGTCTGTTGCTGTCAGCTATGACTCAGTCCCCTGATTAACTTACGCACCACCCATTTTATCCCCTGCAGAGATG CTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGAC ATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAG ATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCA GGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGT TACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACC TTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAG GGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGC GGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACT ATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAA CAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAAC CTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGC CCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCC TGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGC TGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAACGGAGGGTGT TGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCG GCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCGTTGCTGCTCTCCAATCCAGCCTACCGCCTCCTTCTGGCCACTTACGCC CGTCCCCCTCGAGGCCCGGGCCCCCCCACACCCGCCTGGGCCAAACCCACCAACACCCAGGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCG CCCCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGT GCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTT GGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCA AGATCTTACGGCCAGATGCCACCAAGAATGCCAGCTTCTCCTTGTTCTCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCC AAACATCATTCGGCTGCTGGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCC CACCAGCTGGAGGACAAGGCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCC AGATCGCCTCCGGCATGCGCTATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAAT CGCAGACTTTGGCATGAGCCGGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATC CTCATGGGGAAGTTCACGACTGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCA CCGACGAGCAGGTCATCGAGAACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGA GCTGATGCTTCGGTGCTGGAGCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATC ACACATCCAGCTGCCCCTCCCTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAG CCCATCACCTCTAATAGAGGCAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCC TTCCTGTTCTTCCTTCCTAGAAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGG GGAGAAATATAGGATAGACACTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTC TCTCCCTGTCACACACTGGACCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTC CTCAGCTTGGGCTTCTTCCTCCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTG TAGCTAGAACTTCTCTAAGCCTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTC TAGTGTAGCTGCCACATTGATTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTG AGGCAATTTTAATCCCCTGCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCT GCACCTCCCTCTGAACCCACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTT CTGTTTCTGGATAATCCAGGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGA GGCCTGGAAGGAATGCAGTCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATT AGGTTTTAAAACCTATAAAATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGT TCGAGACCAACCTGGCCAACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGG AGGCTGAGGCAGGAGAATTGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGT CTCAAAAACAGAACAACAACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAA ACTAATGTGCTTCTTTTTCATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F1 (forward primer)
DDR1.R1 (reverse primer)
Multiple exon skipping

Frame 0

LGSYLTDLCPSFFMC*IWIVIVSTL*SDCEDKI MDSV*GFRPVSGTGEAF*KYS*CC*TMTVVVVLL LLSPKRPILSVAVSYDSVP*LTYAPPILSPAEM LPPPP*ARGIRSYGTRGPVIFTAAALGGKWRC* HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQLLVR FHCRPPQQVGEQ*RGWGLVPRRVGVSQGGGVLA GGSTTTAPGGSGGHPGTACRGPGQGVLPELPAA LLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGAEGP WAPHGCPTGSLLPPG*PGHERLSAGRALWLPLE GWTPVLHRPCGADNVFI*GRVPQRLHL*RTYRG RTAVWGSGPAGRWCGGAG*L*EESGAAGLARL*L CGMEQPQLLQWLCGDGV*V*PAEGLPGYAGPL* QHAHAGSPSAWRGGMSLPAWPCHGLGGGAHAPQ PRGQPGGPQSPGCLSAPWRPCGSLSAVPLPLCGA LVTLQRNLLHL*CGEQFLSGTGRHLPASPLVAA WPTSHQLQQLGAGAQRPAARGQGRGEPDRHPHR LPGGHHPAPAAHHCPHALAAALAQAPQQG*TEGV GRGADGSPLCPWGHYPHQQPPRS*RATPVPGAP ASWESAPLRSLCPQWLCVAALQSSLPPPSGHLR PSPSRPGPPHTRLGQTHQHPGLQWGLYGA*EARR PASAPTSPEQRPPLCRG*HCYPAGRHRGQHLCC ACTAPRGSRGWAPQSGFPSISTPLQGEAWRGPV WGGAPV*GRQPSRSG*S*FPP*CA*GTPFAGSCQ DLTARCHQECQLLLVLQE*FPERGEDHVEAQGP KHHSAAGRVCAGRPPLHDY*LHGERRPQPVPQC PPAGGQGSRGGPWGRAGCAGAHHQLPNAAACGSP DRLRHALSGHTQLCTSGPGHAELPSWGKFHHQN RRLWHEPEPLCWGLLPCAGPGSAAHPLDGLGVH PHGEVHDCE*RVGLWCDPVGGADAL*GPALWAAH RRAGHRERGGVLPGPGPAGVPVPAACLPAGPI* ADASVLEPGV*AATTLFPAASVPGRGCTQHGVN HTSSCPSLRERSRGSQ*H*NKRTQWHLCPSPPDS PSPLIEAVRLQVGWAHPGS*CPFSPSWTHSHVP FLFFLPRSPCRPPSWSCGWDPLHPPLAIPWGRV GRNIG*TLDMAHWSTWAPLDNTDSWRGGCAPSFS LPVTHWTPLAENLGVRRTRRRGKCFLVPAPVLV LSLGFFLLHHLKHWTWG*PRPSPQSPPLPTCSL VARTSLSLYVSVE*ILGLGGKREQRPIALGLDIS SVAATLIFL*SLGVCTFLGGETQIFTLIYGPSL RQF*SPALGR***RLSFPQLCEWVPWEFGNSAS CTSL*THFPTHFPSSFFPASSFHFPSPVLPSIVF CFWIIQAFACGTSGDA*MSECMNLLNSEGCSGG GLEGMQSGQGC*TFFVP*TPLAVCRGLLSPPQN *VLKPIKWTRHSGSPL*SQHFGRLRWVDHLRPGV RDQPGQHSKTPSLLKIQKLAGCGGMRL*SQLFR RLRQENCLEPGRWGLQ*AEITQLCSSLGNRVRL SQKQNNNNNKTHKMYRIIRETNGNSLPKC*KIMK LMCFFFMYLITRSKNRCNKLTFSKY

Frame 1

*EVI*LISALVSSCVKYG***YLPYEVTVKIKL WILFKGLGQCLAQGKHSKNIADAVKQ*LLLLFY CYYPQSGPFCLLLSAMTQSPD*LTHHPFYPLQRC CPHPLRPEGSGAMGPEALSSLLLLLLVASGDAD MKGHFDPAKCRYALGMQDRTIPDSDISASSSWS DSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQ VDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKD LGPPMVARLVRFYPRADRVMSVCLRVELYGCLWR DGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVG GLQYGGLGQLADGVVGLDDFRKSQELRVWPGYD YVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCN NMHTLGARLPGGVECRFRRGPAMAWEGEPMRHN LGGNLGDPRARAVSVPLGGRVARFLQCRFLFAG PWLLFSEISFISDVVNNSSPALGGTFPPAPWWPP GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIG CLVAIILLLLLIIALMLWRLHWRRLLSKAERRV LEEELTVHLSVPGDTILINNRPGPREPPPYQEPR PRGNPPHSAPCVPNGSALLLSNPAYRLLLATYA RPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPG APLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAV PALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQF GEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV KILRPDATKNASFSLFSRNDFLKEVKIMSRLKDP NIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA HQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAA QIASGMRYLATLNFVHRDLATRNCLVGENFTIKI ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECI LMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQL TDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYE LMLRCWSRESEQRPPFSQLHRFLAEDALNTV*I THPAAPPSGSDPGEASDTKTRGHNGTSALPLPT AHHL**RQ*DCRWAGPTQGADAPSPLPGHTLMSP SCSSFLEAPVAHPAGPVDGILSTLL*PSLGEGW GEI*DRHWTWPIGAPGPHWTTLIPGEVAAPPAS LSLSHTGPHWLRIWG*GGQEGEENVSLCLLLYLS SAWASSSSIT*NTGPGGSPAPALSHPHFPLAVL *LELL*AYTFLWSKYWDWGERGSNGP*PWGWTS LV*LPH*FFYNHLGFVHFWGERHRFLH*YMDLA* GNFNPLH*AGNNKG*VFHNCVSGFLGNLVTLPP APPSEPTSQPTSHLPFFLPPHSISHHLFCPALC SVSG*SRPLPVGPQEMHECLSA*TFSTQRGALVE AWKECSQARGAEPFLCHKRLWQSVEVY*VLLRI RF*NL*NGPGIVAHPCNPSTLGG*GG*IT*GQE FETNLANIAKPHLY*RYKN*QGVVACACNLSYSG G*GRRIA*NPGGGGCSELRSHNCAPAWATE*DC LKNRTTTTTKPIKCIGL*GKPMETVYQNAKKL* N*CASFSCI**QDLKTGVIN*HFPNT

Frame 2

RKLFN*SLP*FLHVLNMDSNSIYLMK*L*R*NY GFCLRV*ASVWHRGSILKI*LMLLNNDCCCCFT VIIPKAAHSVCCCQL*LSPLINLRTTHFIPCRD AAPTPLGPRDQELWDQRPCHLYCCCSWWQVEMLT *RDILILPSAAMPWACRTGPSQTVTSLLPAPGQ IPLPPATAGWRAVTGMGPGAPQGRCFPRRRSTC RWIYNDCTWWLWWAPRDGMPGAWARSSPGATGCV TPGMVAAGWAGRTAGVRR*SQAMRTLREWC*RT LGPPWLPDWFASTPGLTGS*ASVCG*SSMAASG GMDSCLTPPLWGRQCIYLRPCTSTTPPMTDIPWA DCSMGVWASWQMVWWGWMTLGRVRSCGSGQAMT MWDGATTASPVAMWRWSLSLTG*GPSRLCRSTV TTCTRWEPVCLAGWNVASGVALPWPGRGSPCATT *GATWGTPEPGLSQCPLAAVWLAFCSAASSLRG PGYSSAKSPSSLMW*TIPLRHWEAPSRQPPGGR LAHLPPTSAAWSWSPEASSPWPRPRGARPPSSSA AWWPSSCSCCSSLPSCSGGCTGAGSSARLNGGC WKRS*RFTSLSLGTLSSSTTAQVLESHPRTRSP GLVGIRPTPLPVSPMALRCCSPIQPTASFWPLTP VPLEARAPPHPPGPNPPTPRPTVGTIWSLRSQA PRFCPHLPRTASPIMPRLTLLPCRASPGATPML CLHCPQGQSGMGPPEWISLDLDSASRRSLARASL GRCTCVRSTALKIWLVLISPLMCVRDTLCW*LS RSYGQMPPRMPASPCSPGMIS*KR*RSCRGSRT QTSFGCWACVCRTTPSA*LLTTWRTATSTSSSVP TSWRTRQPRGPLGTGRLRRGPPSATQCCCMWQP RSPPACAIWPHSTLYIGTWPRGTA*LGKISPSK SQTLA*AGTSMLGTITVCRAGQCCPSAGWPGSAS SWGSSRLRVTCGPLV*PCGRC*CSVGPSPLGSS PTSRSSRTRGSSSGTRAGRCTCPGRLPARRAYM S*CFGAGAGSLSSDHPFPSCIGSWQRMHSTRCES HIQLPLPQGAIQGKPVTLKQEDTMAPLPFPSRQ PITSNRGSETAGGLGPPRELMPLLPFLDTLSCP LPVLPS*KPLSPTQLVLWMGSSPPSSSHPLGKGG EKYRIDTGHGPLEHLGPTGQH*FLERWLRPQLL SPCHTLDPTG*ESGGEEDKKERKMFPCACSCTC PQLGLLPPPSPETLDLGVAPPQPSVTPTSHLQSC S*NFSKPIRFCGVNIGIGGKEGATAHSLGVGHL *CSCHIDFSIITWGLYIFGGRDTDFYTNIWT*L EAILIPCTRQVIIKVEFSTTV*VGSLGIW*LCLL HLPLNPLPNPLPIFLFSCLLIPFPITCFAQHCV LFLDNPGLCLWDLRRCMNV*VHEPSQLRGVLWW RPGRNAVRPGVLNLFCAINAFGSL*RSTESSSEL GFKTYKMDQA*WLTPVIPALWEAEVGRSLEARS SRPTWPT*QNPISTKDTKISRVWWHAPVISAIQ EAEAGELLRTREVGVAVS*DHTTVLQPGQQSETV SKTEQQQQQNP*NV*DYKGNQWKQFTKMLKNYE TNVLLFHVFNNKI*KQV**TDIFQIL