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Sequences

Sequence DDR1.gAug05

GCCCCAGCCCTGGCTCCTCTCCCCGGAACAGGCCCCCGACAGCTGCTCTCGGGAGCCGCCTCCCGACACCCGAGCCCCGCCGGCGCCTCCCGCTCCCGGC
TCCCGGCTCCTGGCTCCCTCCGCCTCCCCCGCCCCTCGCCCCGCCGCCGAAGAGGCCCCGCTCCCGGGTCGGACGCCTGGGTCTGCCGGGAAGAGCGATG
AGAGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGA
GATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCT
CCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGA
GTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTAC
CGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGC
TGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTG
CCTCTGGAGGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACAT
ACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAG
GCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGT
CCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATG
CGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCT
TTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTG
GTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATC
CTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAAC
GGAGGGTGTTGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCA
GGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCGCC
CCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGTGC
CTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGG
GGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAG
ATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGG
GCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGC
AGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGC
TATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGGCATGAGCC
GGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAGTTCACGAC
TGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGGTCATCGAG
AACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCGGTGCTGGA
GCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCTGCCCCTCC
CTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCTAATAGAGG
CAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTCCTTCCTAG
AAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAGGATAGACA
CTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCACACACTGGA
CCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGCTTCTTCCT
CCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTTCTCTAAGC
CTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGCCACATTGA
TTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGC
ACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCAC
TTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGG
CCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTC
AGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAA
TGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAAC
ATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTG
CTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAAC
AACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCA
TGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA
  • DDR1.F1 (forward primer)
  • DDR1.R1 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

APALAPLPGTGPRQLLSGAASRHPSPAGASRSR
LPAPGSLRLPRPSPRRRRGPAPGSDAWVCREER*
ERCCPHPLRPEGSGAMGPEALSSLLLLLLVASG
DADMKGHFDPAKCRYALGMQDRTIPDSDISASS
SWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEE
YLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSY
RLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVV
LKDLGPPMVARLVRFYPRADRVMSVCLRVELYGC
LWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGH
TVGGLQYGGLGQLADGVVGLDDFRKSQELRVWP
GYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQV
HCNNMHTLGARLPGGVECRFRRGPAMAWEGEPM
RHNLGGNLGDPRARAVSVPLGGRVARFLQCRFL
FAGPWLLFSEISFISDVVNNSSPALGGTFPPAPW
WPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI
LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAE
RRVLEEELTVHLSVPGDTILINNRPGPREPPPYQ
EPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGA
PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAV
PALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFG
EVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVK
ILRPDATKNARNDFLKEVKIMSRLKDPNIIRLL
GVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA
AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMR
YLATLNFVHRDLATRNCLVGENFTIKIADFGMS
RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT
ASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIE
NAGEFFRDQGRQVYLSRPPACPQGLYELMLRCW
SRESEQRPPFSQLHRFLAEDALNTV*ITHPAAPP
SGSDPGEASDTKTRGHNGTSALPLPTAHHL**R
Q*DCRWAGPTQGADAPSPLPGHTLMSPSCSSFL
EAPVAHPAGPVDGILSTLL*PSLGEGWGEI*DRH
WTWPIGAPGPHWTTLIPGEVAAPPASLSLSHTG
PHWLRIWG*GGQEGEENVSLCLLLYLSSAWASS
SSIT*NTGPGGSPAPALSHPHFPLAVL*LELL*A
YTFLWSKYWDWGERGSNGP*PWGWTSLV*LPH*
FFYNHLGFVHFWGERHRFLH*YMDLA*GNFNPL
H*AGNNKG*VFHNCVSGFLGNLVTLPPAPPSEPT
SQPTSHLPFFLPPHSISHHLFCPALCSVSG*SR
PLPVGPQEMHECLSA*TFSTQRGALVEAWKECS
QARGAEPFLCHKRLWQSVEVY*VLLRIRF*NL*N
GPGIVAHPCNPSTLGG*GG*IT*GQEFETNLAN
IAKPHLY*RYKN*QGVVACACNLSYSGG*GRRI
A*NPGGGGCSELRSHNCAPAWATE*DCLKNRTTT
TTKPIKCIGL*GKPMETVYQNAKKL*N*CASFS
CI**QDLKTGVIN*HFPNT

Frame 1

PQPWLLSPEQAPDSCSREPPPDTRAPPAPPAPG
SRLLAPSASPAPRPAAEEAPLPGRTPGSAGKSD
ERDAAPTPLGPRDQELWDQRPCHLYCCCSWWQVE
MLT*RDILILPSAAMPWACRTGPSQTVTSLLPA
PGQIPLPPATAGWRAVTGMGPGAPQGRCFPRRR
STCRWIYNDCTWWLWWAPRDGMPGAWARSSPGAT
GCVTPGMVAAGWAGRTAGVRR*SQAMRTLREWC
*RTLGPPWLPDWFASTPGLTGS*ASVCG*SSMA
ASGGMDSCLTPPLWGRQCIYLRPCTSTTPPMTDI
PWADCSMGVWASWQMVWWGWMTLGRVRSCGSGQ
AMTMWDGATTASPVAMWRWSLSLTG*GPSRLCR
STVTTCTRWEPVCLAGWNVASGVALPWPGRGSPC
ATT*GATWGTPEPGLSQCPLAAVWLAFCSAASS
LRGPGYSSAKSPSSLMW*TIPLRHWEAPSRQPP
GGRLAHLPPTSAAWSWSPEASSPWPRPRGARPPS
SSAAWWPSSCSCCSSLPSCSGGCTGAGSSARLN
GGCWKRS*RFTSLSLGTLSSSTTAQVLESHPRT
RSPGLVGIRPTPLPVSPMALPTVGTIWSLRSQAP
RFCPHLPRTASPIMPRLTLLPCRASPGATPMLC
LHCPQGQSGMGPPEWISLDLDSASRRSLARASL
GRCTCVRSTALKIWLVLISPLMCVRDTLCW*LSR
SYGQMPPRMPGMIS*KR*RSCRGSRTQTSFGCW
ACVCRTTPSA*LLTTWRTATSTSSSVPTSWRTR
QPRGPLGTGRLRRGPPSATQCCCMWQPRSPPACA
IWPHSTLYIGTWPRGTA*LGKISPSKSQTLA*A
GTSMLGTITVCRAGQCCPSAGWPGSASSWGSSR
LRVTCGPLV*PCGRC*CSVGPSPLGSSPTSRSSR
TRGSSSGTRAGRCTCPGRLPARRAYMS*CFGAG
AGSLSSDHPFPSCIGSWQRMHSTRCESHIQLPL
PQGAIQGKPVTLKQEDTMAPLPFPSRQPITSNRG
SETAGGLGPPRELMPLLPFLDTLSCPLPVLPS*
KPLSPTQLVLWMGSSPPSSSHPLGKGGEKYRID
TGHGPLEHLGPTGQH*FLERWLRPQLLSPCHTLD
PTG*ESGGEEDKKERKMFPCACSCTCPQLGLLP
PPSPETLDLGVAPPQPSVTPTSHLQSCS*NFSK
PIRFCGVNIGIGGKEGATAHSLGVGHL*CSCHID
FSIITWGLYIFGGRDTDFYTNIWT*LEAILIPC
TRQVIIKVEFSTTV*VGSLGIW*LCLLHLPLNP
LPNPLPIFLFSCLLIPFPITCFAQHCVLFLDNPG
LCLWDLRRCMNV*VHEPSQLRGVLWWRPGRNAV
RPGVLNLFCAINAFGSL*RSTESSSELGFKTYK
MDQA*WLTPVIPALWEAEVGRSLEARSSRPTWPT
*QNPISTKDTKISRVWWHAPVISAIQEAEAGEL
LRTREVGVAVS*DHTTVLQPGQQSETVSKTEQQ
QQQNP*NV*DYKGNQWKQFTKMLKNYETNVLLFH
VFNNKI*KQV**TDIFQIL

Frame 2

PSPGSSPRNRPPTAALGSRLPTPEPRRRLPLPA
PGSWLPPPPPPLAPPPKRPRSRVGRLGLPGRAM
REMLPPPP*ARGIRSYGTRGPVIFTAAALGGKW
RC*HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQL
LVRFHCRPPQQVGEQ*RGWGLVPRRVGVSQGGG
VLAGGSTTTAPGGSGGHPGTACRGPGQGVLPEL
PAALLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGA
EGPWAPHGCPTGSLLPPG*PGHERLSAGRALWL
PLEGWTPVLHRPCGADNVFI*GRVPQRLHL*RT
YRGRTAVWGSGPAGRWCGGAG*L*EESGAAGLAR
L*LCGMEQPQLLQWLCGDGV*V*PAEGLPGYAG
PL*QHAHAGSPSAWRGGMSLPAWPCHGLGGGAH
APQPRGQPGGPQSPGCLSAPWRPCGSLSAVPLPL
CGALVTLQRNLLHL*CGEQFLSGTGRHLPASPL
VAAWPTSHQLQQLGAGAQRPAARGQGRGEPDRH
PHRLPGGHHPAPAAHHCPHALAAALAQAPQQG*T
EGVGRGADGSPLCPWGHYPHQQPPRS*RATPVP
GAPASWESAPLRSLCPQWLCLQWGLYGA*EARR
PASAPTSPEQRPPLCRG*HCYPAGRHRGQHLCCA
CTAPRGSRGWAPQSGFPSISTPLQGEAWRGPVW
GGAPV*GRQPSRSG*S*FPP*CA*GTPFAGSCQ
DLTARCHQECQE*FPERGEDHVEAQGPKHHSAAG
RVCAGRPPLHDY*LHGERRPQPVPQCPPAGGQG
SRGGPWGRAGCAGAHHQLPNAAACGSPDRLRHA
LSGHTQLCTSGPGHAELPSWGKFHHQNRRLWHEP
EPLCWGLLPCAGPGSAAHPLDGLGVHPHGEVHD
CE*RVGLWCDPVGGADAL*GPALWAAHRRAGHR
ERGGVLPGPGPAGVPVPAACLPAGPI*ADASVLE
PGV*AATTLFPAASVPGRGCTQHGVNHTSSCPS
LRERSRGSQ*H*NKRTQWHLCPSPPDSPSPLIE
AVRLQVGWAHPGS*CPFSPSWTHSHVPFLFFLPR
SPCRPPSWSCGWDPLHPPLAIPWGRVGRNIG*T
LDMAHWSTWAPLDNTDSWRGGCAPSFSLPVTHW
TPLAENLGVRRTRRRGKCFLVPAPVLVLSLGFFL
LHHLKHWTWG*PRPSPQSPPLPTCSLVARTSLS
LYVSVE*ILGLGGKREQRPIALGLDISSVAATL
IFL*SLGVCTFLGGETQIFTLIYGPSLRQF*SPA
LGR***RLSFPQLCEWVPWEFGNSASCTSL*TH
FPTHFPSSFFPASSFHFPSPVLPSIVFCFWIIQ
AFACGTSGDA*MSECMNLLNSEGCSGGGLEGMQS
GQGC*TFFVP*TPLAVCRGLLSPPQN*VLKPIK
WTRHSGSPL*SQHFGRLRWVDHLRPGVRDQPGQ
HSKTPSLLKIQKLAGCGGMRL*SQLFRRLRQENC
LEPGRWGLQ*AEITQLCSSLGNRVRLSQKQNNN
NNKTHKMYRIIRETNGNSLPKC*KIMKLMCFFF
MYLITRSKNRCNKLTFSKY

Sequence DDR1.fAug05

GATCCCAGAAGTAGGAGGGGCGTCTTCCCCTCGTGGGCCCTGAGCGGGACTGCAGCCAGCCCCCTGGGGCGCCAGCTTTGGAGGCCCCCGACAGCTGCTC
TCGGGAGCCGCCTCCCGACACCCGAGCCCCGCCGGCGCCTCCCGCTCCCGGCTCCCGGCTCCTGGCTCCCTCCGCCTCCCCCGCCCCTCGCCCCGCCGCC
GAAGAGGCCCCGCTCCCGGGTCGGACGCCTGGGTCTGCCGGGAAGAGCGATGAGAGGTGTCTGAAGGTGGCTATTCACTGAGCGATGGGGTTGGACTTGA
AGGAATGCCAAGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGG
CAAGTGGAGATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGC
TTCCAGCTCCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAG
GAGGAGGAGTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCC
GGAGCTACCGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGG
AGTGGTGCTGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTC
TATGGCTGCCTCTGGAGGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATG
ACGGACATACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGT
CTGGCCAGGCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCT
ATGCAGGTCCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGG
AGCCCATGCGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCG
CTTCCTCTTTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCA
GCCCCCTGGTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGA
CCGCCATCCTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAA
GGCTGAACGGAGGGTGTTGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCC
CCGTACCAGGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCCTACAGTGGGGACTATATGGAGCCTGAGAAGC
CAGGCGCCCCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTA
TGCTGTGCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGC
CAGTTTGGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAG
CTGTCAAGATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCG
GCTGCTGGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAG
GACAAGGCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCG
GCATGCGCTATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGG
CATGAGCCGGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAG
TTCACGACTGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGG
TCATCGAGAACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCG
GTGCTGGAGCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCT
GCCCCTCCCTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCT
AATAGAGGCAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTC
CTTCCTAGAAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAG
GATAGACACTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCAC
ACACTGGACCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGC
TTCTTCCTCCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTT
CTCTAAGCCTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGC
CACATTGATTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAA
TCCCCTGCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCT
GAACCCACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGAT
AATCCAGGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGA
ATGCAGTCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAAC
CTATAAAATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACC
TGGCCAACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAG
GAGAATTGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGA
ACAACAACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTT
CTTTTTCATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA
  • DDR1.F1 (forward primer)
  • DDR1.R1 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DPRSRRGVFPSWALSGTAASPLGRQLWRPPTAA
LGSRLPTPEPRRRLPLPAPGSWLPPPPPPLAPPP
KRPRSRVGRLGLPGRAMRGV*RWLFTERWGWT*
RNAKRCCPHPLRPEGSGAMGPEALSSLLLLLLV
ASGDADMKGHFDPAKCRYALGMQDRTIPDSDISA
SSSWSDSTAARHSRLESSDGDGAWCPAGSVFPK
EEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFS
RSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEG
VVLKDLGPPMVARLVRFYPRADRVMSVCLRVEL
YGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTY
DGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRV
WPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQA
MQVHCNNMHTLGARLPGGVECRFRRGPAMAWEG
EPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCR
FLFAGPWLLFSEISFISDVVNNSSPALGGTFPP
APWWPPGPPPTNFSSLELEPRGQQPVAKAEGSP
TAILIGCLVAIILLLLLIIALMLWRLHWRRLLSK
AERRVLEEELTVHLSVPGDTILINNRPGPREPP
PYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEK
PGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTY
AVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEG
QFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV
AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIR
LLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE
DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIAS
GMRYLATLNFVHRDLATRNCLVGENFTIKIADFG
MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK
FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQ
VIENAGEFFRDQGRQVYLSRPPACPQGLYELMLR
CWSRESEQRPPFSQLHRFLAEDALNTV*ITHPA
APPSGSDPGEASDTKTRGHNGTSALPLPTAHHL
**RQ*DCRWAGPTQGADAPSPLPGHTLMSPSCSS
FLEAPVAHPAGPVDGILSTLL*PSLGEGWGEI*
DRHWTWPIGAPGPHWTTLIPGEVAAPPASLSLS
HTGPHWLRIWG*GGQEGEENVSLCLLLYLSSAWA
SSSSIT*NTGPGGSPAPALSHPHFPLAVL*LEL
L*AYTFLWSKYWDWGERGSNGP*PWGWTSLV*L
PH*FFYNHLGFVHFWGERHRFLH*YMDLA*GNFN
PLH*AGNNKG*VFHNCVSGFLGNLVTLPPAPPS
EPTSQPTSHLPFFLPPHSISHHLFCPALCSVSG
*SRPLPVGPQEMHECLSA*TFSTQRGALVEAWKE
CSQARGAEPFLCHKRLWQSVEVY*VLLRIRF*N
L*NGPGIVAHPCNPSTLGG*GG*IT*GQEFETN
LANIAKPHLY*RYKN*QGVVACACNLSYSGG*GR
RIA*NPGGGGCSELRSHNCAPAWATE*DCLKNR
TTTTTKPIKCIGL*GKPMETVYQNAKKL*N*CA
SFSCI**QDLKTGVIN*HFPNT

Frame 1

IPEVGGASSPRGP*AGLQPAPWGASFGGPRQLL
SGAASRHPSPAGASRSRLPAPGSLRLPRPSPRR
RRGPAPGSDAWVCREER*EVSEGGYSLSDGVGLE
GMPRDAAPTPLGPRDQELWDQRPCHLYCCCSWW
QVEMLT*RDILILPSAAMPWACRTGPSQTVTSL
LPAPGQIPLPPATAGWRAVTGMGPGAPQGRCFPR
RRSTCRWIYNDCTWWLWWAPRDGMPGAWARSSP
GATGCVTPGMVAAGWAGRTAGVRR*SQAMRTLR
EWC*RTLGPPWLPDWFASTPGLTGS*ASVCG*SS
MAASGGMDSCLTPPLWGRQCIYLRPCTSTTPPM
TDIPWADCSMGVWASWQMVWWGWMTLGRVRSCG
SGQAMTMWDGATTASPVAMWRWSLSLTG*GPSRL
CRSTVTTCTRWEPVCLAGWNVASGVALPWPGRG
SPCATT*GATWGTPEPGLSQCPLAAVWLAFCSA
ASSLRGPGYSSAKSPSSLMW*TIPLRHWEAPSRQ
PPGGRLAHLPPTSAAWSWSPEASSPWPRPRGAR
PPSSSAAWWPSSCSCCSSLPSCSGGCTGAGSSA
RLNGGCWKRS*RFTSLSLGTLSSSTTAQVLESHP
RTRSPGLVGIRPTPLPVSPMALPTVGTIWSLRS
QAPRFCPHLPRTASPIMPRLTLLPCRASPGATP
MLCLHCPQGQSGMGPPEWISLDLDSASRRSLARA
SLGRCTCVRSTALKIWLVLISPLMCVRDTLCW*
LSRSYGQMPPRMPGMIS*KR*RSCRGSRTQTSF
GCWACVCRTTPSA*LLTTWRTATSTSSSVPTSWR
TRQPRGPLGTGRLRRGPPSATQCCCMWQPRSPP
ACAIWPHSTLYIGTWPRGTA*LGKISPSKSQTL
A*AGTSMLGTITVCRAGQCCPSAGWPGSASSWGS
SRLRVTCGPLV*PCGRC*CSVGPSPLGSSPTSR
SSRTRGSSSGTRAGRCTCPGRLPARRAYMS*CF
GAGAGSLSSDHPFPSCIGSWQRMHSTRCESHIQL
PLPQGAIQGKPVTLKQEDTMAPLPFPSRQPITS
NRGSETAGGLGPPRELMPLLPFLDTLSCPLPVL
PS*KPLSPTQLVLWMGSSPPSSSHPLGKGGEKYR
IDTGHGPLEHLGPTGQH*FLERWLRPQLLSPCH
TLDPTG*ESGGEEDKKERKMFPCACSCTCPQLG
LLPPPSPETLDLGVAPPQPSVTPTSHLQSCS*NF
SKPIRFCGVNIGIGGKEGATAHSLGVGHL*CSC
HIDFSIITWGLYIFGGRDTDFYTNIWT*LEAIL
IPCTRQVIIKVEFSTTV*VGSLGIW*LCLLHLPL
NPLPNPLPIFLFSCLLIPFPITCFAQHCVLFLD
NPGLCLWDLRRCMNV*VHEPSQLRGVLWWRPGR
NAVRPGVLNLFCAINAFGSL*RSTESSSELGFKT
YKMDQA*WLTPVIPALWEAEVGRSLEARSSRPT
WPT*QNPISTKDTKISRVWWHAPVISAIQEAEA
GELLRTREVGVAVS*DHTTVLQPGQQSETVSKTE
QQQQQNP*NV*DYKGNQWKQFTKMLKNYETNVL
LFHVFNNKI*KQV**TDIFQIL

Frame 2

SQK*EGRLPLVGPERDCSQPPGAPALEAPDSCS
REPPPDTRAPPAPPAPGSRLLAPSASPAPRPAA
EEAPLPGRTPGSAGKSDERCLKVAIH*AMGLDL
KECQEMLPPPP*ARGIRSYGTRGPVIFTAAALGG
KWRC*HEGTF*SCQVPLCPGHAGPDHPRQ*HLC
FQLLVRFHCRPPQQVGEQ*RGWGLVPRRVGVSQ
GGGVLAGGSTTTAPGGSGGHPGTACRGPGQGVLP
ELPAALLPGWSPLDGLEGPLGSGGDLRQ*GP*G
SGAEGPWAPHGCPTGSLLPPG*PGHERLSAGRA
LWLPLEGWTPVLHRPCGADNVFI*GRVPQRLHL*
RTYRGRTAVWGSGPAGRWCGGAG*L*EESGAAG
LARL*LCGMEQPQLLQWLCGDGV*V*PAEGLPG
YAGPL*QHAHAGSPSAWRGGMSLPAWPCHGLGGG
AHAPQPRGQPGGPQSPGCLSAPWRPCGSLSAVP
LPLCGALVTLQRNLLHL*CGEQFLSGTGRHLPA
SPLVAAWPTSHQLQQLGAGAQRPAARGQGRGEPD
RHPHRLPGGHHPAPAAHHCPHALAAALAQAPQQ
G*TEGVGRGADGSPLCPWGHYPHQQPPRS*RAT
PVPGAPASWESAPLRSLCPQWLCLQWGLYGA*EA
RRPASAPTSPEQRPPLCRG*HCYPAGRHRGQHL
CCACTAPRGSRGWAPQSGFPSISTPLQGEAWRG
PVWGGAPV*GRQPSRSG*S*FPP*CA*GTPFAGS
CQDLTARCHQECQE*FPERGEDHVEAQGPKHHS
AAGRVCAGRPPLHDY*LHGERRPQPVPQCPPAG
GQGSRGGPWGRAGCAGAHHQLPNAAACGSPDRLR
HALSGHTQLCTSGPGHAELPSWGKFHHQNRRLW
HEPEPLCWGLLPCAGPGSAAHPLDGLGVHPHGE
VHDCE*RVGLWCDPVGGADAL*GPALWAAHRRAG
HRERGGVLPGPGPAGVPVPAACLPAGPI*ADAS
VLEPGV*AATTLFPAASVPGRGCTQHGVNHTSS
CPSLRERSRGSQ*H*NKRTQWHLCPSPPDSPSPL
IEAVRLQVGWAHPGS*CPFSPSWTHSHVPFLFF
LPRSPCRPPSWSCGWDPLHPPLAIPWGRVGRNI
G*TLDMAHWSTWAPLDNTDSWRGGCAPSFSLPVT
HWTPLAENLGVRRTRRRGKCFLVPAPVLVLSLG
FFLLHHLKHWTWG*PRPSPQSPPLPTCSLVART
SLSLYVSVE*ILGLGGKREQRPIALGLDISSVAA
TLIFL*SLGVCTFLGGETQIFTLIYGPSLRQF*
SPALGR***RLSFPQLCEWVPWEFGNSASCTSL
*THFPTHFPSSFFPASSFHFPSPVLPSIVFCFWI
IQAFACGTSGDA*MSECMNLLNSEGCSGGGLEG
MQSGQGC*TFFVP*TPLAVCRGLLSPPQN*VLK
PIKWTRHSGSPL*SQHFGRLRWVDHLRPGVRDQP
GQHSKTPSLLKIQKLAGCGGMRL*SQLFRRLRQ
ENCLEPGRWGLQ*AEITQLCSSLGNRVRLSQKQ
NNNNNKTHKMYRIIRETNGNSLPKC*KIMKLMCF
FFMYLITRSKNRCNKLTFSKY

Sequence DDR1.eAug05

TTAGGAAGTTATTTAACTGATCTCTGCCCTAGTTTCTTCATGTGTTAAATATGGATAGTAATAGTATCTACCTTATGAAGTGACTGTGAAGATAAAATTA
TGGATTCTGTTTAAGGGTTTAGGCCAGTGTCTGGCACAGGGGAAGCATTCTAAAAATATAGCTGATGCTGTTAAACAATGACTGTTGTTGTTGTTTTACT
GTTATTATCCCCAAAGCGGCCCATTCTGTCTGTTGCTGTCAGCTATGACTCAGTCCCCTGATTAACTTACGCACCACCCATTTTATCCCCTGCAGAGATG
CTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGAC
ATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAG
ATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCA
GGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGT
TACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACC
TTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAG
GGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGC
GGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACT
ATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAA
CAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAAC
CTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGC
CCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCC
TGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGC
TGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAACGGAGGGTGT
TGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCG
GCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCGCCCCGCTTCTG
CCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGTGCCTGCACTGC
CCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGGGGAGGTGCA
CCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAGATCTTACGG
CCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGGGCGTGTGTG
TGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGCAGCCGAGGG
GGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGCTATCTGGCC
ACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGGCATGAGCCGGAACCTCT
ATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAGTTCACGACTGCGAGTGA
CGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGGTCATCGAGAACGCGGGG
GAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCGGTGCTGGAGCCGGGAGT
CTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCTGCCCCTCCCTCAGGGAG
CGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCTAATAGAGGCAGTGAGAC
TGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTCCTTCCTAGAAGCCCCTG
TCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAGGATAGACACTGGACATG
GCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCACACACTGGACCCCACTGG
CTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGCTTCTTCCTCCTCCATCA
CCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTTCTCTAAGCCTATACGTT
TCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGCCACATTGATTTTTCTAT
AATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGCACTAGGCAG
GTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCACTTCCCAACC
CACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGGCCTTTGCCT
GTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTCAGGCCAGGG
GTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAATGGACCAGG
CATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATAGCAAAA
CCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTGCTTAGAACC
CGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAACAACAACAAA
ACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCATGTATTTAA
TAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA
  • DDR1.F1 (forward primer)
  • DDR1.R1 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

LGSYLTDLCPSFFMC*IWIVIVSTL*SDCEDKI
MDSV*GFRPVSGTGEAF*KYS*CC*TMTVVVVLL
LLSPKRPILSVAVSYDSVP*LTYAPPILSPAEM
LPPPP*ARGIRSYGTRGPVIFTAAALGGKWRC*
HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQLLVR
FHCRPPQQVGEQ*RGWGLVPRRVGVSQGGGVLA
GGSTTTAPGGSGGHPGTACRGPGQGVLPELPAA
LLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGAEGP
WAPHGCPTGSLLPPG*PGHERLSAGRALWLPLE
GWTPVLHRPCGADNVFI*GRVPQRLHL*RTYRG
RTAVWGSGPAGRWCGGAG*L*EESGAAGLARL*L
CGMEQPQLLQWLCGDGV*V*PAEGLPGYAGPL*
QHAHAGSPSAWRGGMSLPAWPCHGLGGGAHAPQ
PRGQPGGPQSPGCLSAPWRPCGSLSAVPLPLCGA
LVTLQRNLLHL*CGEQFLSGTGRHLPASPLVAA
WPTSHQLQQLGAGAQRPAARGQGRGEPDRHPHR
LPGGHHPAPAAHHCPHALAAALAQAPQQG*TEGV
GRGADGSPLCPWGHYPHQQPPRS*RATPVPGAP
ASWESAPLRSLCPQWLCLQWGLYGA*EARRPAS
APTSPEQRPPLCRG*HCYPAGRHRGQHLCCACTA
PRGSRGWAPQSGFPSISTPLQGEAWRGPVWGGA
PV*GRQPSRSG*S*FPP*CA*GTPFAGSCQDLT
ARCHQECQE*FPERGEDHVEAQGPKHHSAAGRVC
AGRPPLHDY*LHGERRPQPVPQCPPAGGQGSRG
GPWGRAGCAGAHHQLPNAAACGSPDRLRHALSG
HTQLCTSGPGHAELPSWGKFHHQNRRLWHEPEPL
CWGLLPCAGPGSAAHPLDGLGVHPHGEVHDCE*
RVGLWCDPVGGADAL*GPALWAAHRRAGHRERG
GVLPGPGPAGVPVPAACLPAGPI*ADASVLEPGV
*AATTLFPAASVPGRGCTQHGVNHTSSCPSLRE
RSRGSQ*H*NKRTQWHLCPSPPDSPSPLIEAVR
LQVGWAHPGS*CPFSPSWTHSHVPFLFFLPRSPC
RPPSWSCGWDPLHPPLAIPWGRVGRNIG*TLDM
AHWSTWAPLDNTDSWRGGCAPSFSLPVTHWTPL
AENLGVRRTRRRGKCFLVPAPVLVLSLGFFLLHH
LKHWTWG*PRPSPQSPPLPTCSLVARTSLSLYV
SVE*ILGLGGKREQRPIALGLDISSVAATLIFL
*SLGVCTFLGGETQIFTLIYGPSLRQF*SPALGR
***RLSFPQLCEWVPWEFGNSASCTSL*THFPT
HFPSSFFPASSFHFPSPVLPSIVFCFWIIQAFA
CGTSGDA*MSECMNLLNSEGCSGGGLEGMQSGQG
C*TFFVP*TPLAVCRGLLSPPQN*VLKPIKWTR
HSGSPL*SQHFGRLRWVDHLRPGVRDQPGQHSK
TPSLLKIQKLAGCGGMRL*SQLFRRLRQENCLEP
GRWGLQ*AEITQLCSSLGNRVRLSQKQNNNNNK
THKMYRIIRETNGNSLPKC*KIMKLMCFFFMYL
ITRSKNRCNKLTFSKY

Frame 1

*EVI*LISALVSSCVKYG***YLPYEVTVKIKL
WILFKGLGQCLAQGKHSKNIADAVKQ*LLLLFY
CYYPQSGPFCLLLSAMTQSPD*LTHHPFYPLQRC
CPHPLRPEGSGAMGPEALSSLLLLLLVASGDAD
MKGHFDPAKCRYALGMQDRTIPDSDISASSSWS
DSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQ
VDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR
YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKD
LGPPMVARLVRFYPRADRVMSVCLRVELYGCLWR
DGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVG
GLQYGGLGQLADGVVGLDDFRKSQELRVWPGYD
YVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCN
NMHTLGARLPGGVECRFRRGPAMAWEGEPMRHN
LGGNLGDPRARAVSVPLGGRVARFLQCRFLFAG
PWLLFSEISFISDVVNNSSPALGGTFPPAPWWPP
GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIG
CLVAIILLLLLIIALMLWRLHWRRLLSKAERRV
LEEELTVHLSVPGDTILINNRPGPREPPPYQEPR
PRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLL
PPPPQNSVPHYAEADIVTLQGVTGGNTYAVPAL
PPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVH
LCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR
PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC
VQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEG
APGDGQAAQGPTISYPMLLHVAAQIASGMRYLA
TLNFVHRDLATRNCLVGENFTIKIADFGMSRNL
YAGDYYRVQGRAVLPIRWMAWECILMGKFTTASD
VWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAG
EFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE
SEQRPPFSQLHRFLAEDALNTV*ITHPAAPPSGS
DPGEASDTKTRGHNGTSALPLPTAHHL**RQ*D
CRWAGPTQGADAPSPLPGHTLMSPSCSSFLEAP
VAHPAGPVDGILSTLL*PSLGEGWGEI*DRHWTW
PIGAPGPHWTTLIPGEVAAPPASLSLSHTGPHW
LRIWG*GGQEGEENVSLCLLLYLSSAWASSSSI
T*NTGPGGSPAPALSHPHFPLAVL*LELL*AYTF
LWSKYWDWGERGSNGP*PWGWTSLV*LPH*FFY
NHLGFVHFWGERHRFLH*YMDLA*GNFNPLH*A
GNNKG*VFHNCVSGFLGNLVTLPPAPPSEPTSQP
TSHLPFFLPPHSISHHLFCPALCSVSG*SRPLP
VGPQEMHECLSA*TFSTQRGALVEAWKECSQAR
GAEPFLCHKRLWQSVEVY*VLLRIRF*NL*NGPG
IVAHPCNPSTLGG*GG*IT*GQEFETNLANIAK
PHLY*RYKN*QGVVACACNLSYSGG*GRRIA*N
PGGGGCSELRSHNCAPAWATE*DCLKNRTTTTTK
PIKCIGL*GKPMETVYQNAKKL*N*CASFSCI*
*QDLKTGVIN*HFPNT

Frame 2

RKLFN*SLP*FLHVLNMDSNSIYLMK*L*R*NY
GFCLRV*ASVWHRGSILKI*LMLLNNDCCCCFT
VIIPKAAHSVCCCQL*LSPLINLRTTHFIPCRD
AAPTPLGPRDQELWDQRPCHLYCCCSWWQVEMLT
*RDILILPSAAMPWACRTGPSQTVTSLLPAPGQ
IPLPPATAGWRAVTGMGPGAPQGRCFPRRRSTC
RWIYNDCTWWLWWAPRDGMPGAWARSSPGATGCV
TPGMVAAGWAGRTAGVRR*SQAMRTLREWC*RT
LGPPWLPDWFASTPGLTGS*ASVCG*SSMAASG
GMDSCLTPPLWGRQCIYLRPCTSTTPPMTDIPWA
DCSMGVWASWQMVWWGWMTLGRVRSCGSGQAMT
MWDGATTASPVAMWRWSLSLTG*GPSRLCRSTV
TTCTRWEPVCLAGWNVASGVALPWPGRGSPCATT
*GATWGTPEPGLSQCPLAAVWLAFCSAASSLRG
PGYSSAKSPSSLMW*TIPLRHWEAPSRQPPGGR
LAHLPPTSAAWSWSPEASSPWPRPRGARPPSSSA
AWWPSSCSCCSSLPSCSGGCTGAGSSARLNGGC
WKRS*RFTSLSLGTLSSSTTAQVLESHPRTRSP
GLVGIRPTPLPVSPMALPTVGTIWSLRSQAPRFC
PHLPRTASPIMPRLTLLPCRASPGATPMLCLHC
PQGQSGMGPPEWISLDLDSASRRSLARASLGRC
TCVRSTALKIWLVLISPLMCVRDTLCW*LSRSYG
QMPPRMPGMIS*KR*RSCRGSRTQTSFGCWACV
CRTTPSA*LLTTWRTATSTSSSVPTSWRTRQPR
GPLGTGRLRRGPPSATQCCCMWQPRSPPACAIWP
HSTLYIGTWPRGTA*LGKISPSKSQTLA*AGTS
MLGTITVCRAGQCCPSAGWPGSASSWGSSRLRV
TCGPLV*PCGRC*CSVGPSPLGSSPTSRSSRTRG
SSSGTRAGRCTCPGRLPARRAYMS*CFGAGAGS
LSSDHPFPSCIGSWQRMHSTRCESHIQLPLPQG
AIQGKPVTLKQEDTMAPLPFPSRQPITSNRGSET
AGGLGPPRELMPLLPFLDTLSCPLPVLPS*KPL
SPTQLVLWMGSSPPSSSHPLGKGGEKYRIDTGH
GPLEHLGPTGQH*FLERWLRPQLLSPCHTLDPTG
*ESGGEEDKKERKMFPCACSCTCPQLGLLPPPS
PETLDLGVAPPQPSVTPTSHLQSCS*NFSKPIR
FCGVNIGIGGKEGATAHSLGVGHL*CSCHIDFSI
ITWGLYIFGGRDTDFYTNIWT*LEAILIPCTRQ
VIIKVEFSTTV*VGSLGIW*LCLLHLPLNPLPN
PLPIFLFSCLLIPFPITCFAQHCVLFLDNPGLCL
WDLRRCMNV*VHEPSQLRGVLWWRPGRNAVRPG
VLNLFCAINAFGSL*RSTESSSELGFKTYKMDQ
A*WLTPVIPALWEAEVGRSLEARSSRPTWPT*QN
PISTKDTKISRVWWHAPVISAIQEAEAGELLRT
REVGVAVS*DHTTVLQPGQQSETVSKTEQQQQQ
NP*NV*DYKGNQWKQFTKMLKNYETNVLLFHVFN
NKI*KQV**TDIFQIL

Sequence DDR1.hAug05

CTAGATTCCCCAGCTGCTGTTCTCTGGAGGGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTA
CTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCC
CAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGC
AGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGC
CTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAG
GCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGT
CTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAGGGACTGGAGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGG
CCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGA
CTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAG
TTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGC
GTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGG
CCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCT
CCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGC
CCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCG
GCTGCACTGGCGCAGGCTCCTCAGCAAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCC
CCAATGGCTCTGCGTTGCTGCTCTCCAATCCAGCCTACCGCCTCCTTCTGGCCACTTACGCCCGTCCCCCTCGAGGCCCGGGCCCCCCCACACCCGCCTG
GGCCAAACCCACCAACACCCAGGGGCGTCACCGGGGGCAACACCTATGCTGTGCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGA
TTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGT
CTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAGATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGA
AAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACAT
GGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACC
ATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGCTATCTGGCCACACTCAACTTTGTACATTTTTGGGGGGAGAGACACA
GATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGG
GTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATT
TCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAA
CCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTC
TGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGC
TGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGG
TGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTG
TGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAA
ACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTC
CAAATACTA
  • DDR1.F1 (forward primer)
  • DDR1.R1 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

LDSPAAVLWREMLPPPP*ARGIRSYGTRGPVIF
TAAALGGKWRC*HEGTF*SCQVPLCPGHAGPDHP
RQ*HLCFQLLVRFHCRPPQQVGEQ*RGWGLVPR
RVGVSQGGGVLAGGSTTTAPGGSGGHPGTACRG
PGQGVLPELPAALLPGWSPLDGLEGPLGSGGDLR
Q*GP*GSGAEGPWAPHGCPTGSLLPPG*PGHER
LSAGRALWLPLEGLEDGLLSYTAPVGQTMYLSE
AVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFE
FDRLRAFQAMQVHCNNMHTLGARLPGGVECRFR
RGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGG
RVARFLQCRFLFAGPWLLFSEISFISDVVNNSS
PALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQ
PVAKAEGSPTAILIGCLVAIILLLLLIIALMLWR
LHWRRLLSKVLESHPRTRSPGLVGIRPTPLPVS
PMALRCCSPIQPTASFWPLTPVPLEARAPPHPP
GPNPPTPRGVTGGNTYAVPALPPGAVGDGPPRVD
FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS
LDFPLNVRKGHPLLVAVKILRPDATKNARNDFL
KEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYM
ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPT
ISYPMLLHVAAQIASGMRYLATLNFVHFWGERH
RFLH*YMDLA*GNFNPLH*AGNNKG*VFHNCVSG
FLGNLVTLPPAPPSEPTSQPTSHLPFFLPPHSI
SHHLFCPALCSVSG*SRPLPVGPQEMHECLSA*
TFSTQRGALVEAWKECSQARGAEPFLCHKRLWQS
VEVY*VLLRIRF*NL*NGPGIVAHPCNPSTLGG
*GG*IT*GQEFETNLANIAKPHLY*RYKN*QGV
VACACNLSYSGG*GRRIA*NPGGGGCSELRSHNC
APAWATE*DCLKNRTTTTTKPIKCIGL*GKPME
TVYQNAKKL*N*CASFSCI**QDLKTGVIN*HF
PNT

Frame 1

*IPQLLFSGGRCCPHPLRPEGSGAMGPEALSSL
LLLLLVASGDADMKGHFDPAKCRYALGMQDRTI
PDSDISASSSWSDSTAARHSRLESSDGDGAWCPA
GSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGG
LGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVIS
GNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSV
CLRVELYGCLWRDWRMDSCLTPPLWGRQCIYLR
PCTSTTPPMTDIPWADCSMGVWASWQMVWWGWM
TLGRVRSCGSGQAMTMWDGATTASPVAMWRWSLS
LTG*GPSRLCRSTVTTCTRWEPVCLAGWNVASG
VALPWPGRGSPCATT*GATWGTPEPGLSQCPLA
AVWLAFCSAASSLRGPGYSSAKSPSSLMW*TIPL
RHWEAPSRQPPGGRLAHLPPTSAAWSWSPEASS
PWPRPRGARPPSSSAAWWPSSCSCCSSLPSCSG
GCTGAGSSARS*RATPVPGAPASWESAPLRSLCP
QWLCVAALQSSLPPPSGHLRPSPSRPGPPHTRL
GQTHQHPGASPGATPMLCLHCPQGQSGMGPPEW
ISLDLDSASRRSLARASLGRCTCVRSTALKIWLV
LISPLMCVRDTLCW*LSRSYGQMPPRMPGMIS*
KR*RSCRGSRTQTSFGCWACVCRTTPSA*LLTT
WRTATSTSSSVPTSWRTRQPRGPLGTGRLRRGPP
SATQCCCMWQPRSPPACAIWPHSTLYIFGGRDT
DFYTNIWT*LEAILIPCTRQVIIKVEFSTTV*V
GSLGIW*LCLLHLPLNPLPNPLPIFLFSCLLIPF
PITCFAQHCVLFLDNPGLCLWDLRRCMNV*VHE
PSQLRGVLWWRPGRNAVRPGVLNLFCAINAFGS
L*RSTESSSELGFKTYKMDQA*WLTPVIPALWEA
EVGRSLEARSSRPTWPT*QNPISTKDTKISRVW
WHAPVISAIQEAEAGELLRTREVGVAVS*DHTT
VLQPGQQSETVSKTEQQQQQNP*NV*DYKGNQWK
QFTKMLKNYETNVLLFHVFNNKI*KQV**TDIF
QIL

Frame 2

RFPSCCSLEGDAAPTPLGPRDQELWDQRPCHLY
CCCSWWQVEMLT*RDILILPSAAMPWACRTGPS
QTVTSLLPAPGQIPLPPATAGWRAVTGMGPGAP
QGRCFPRRRSTCRWIYNDCTWWLWWAPRDGMPGA
WARSSPGATGCVTPGMVAAGWAGRTAGVRR*SQ
AMRTLREWC*RTLGPPWLPDWFASTPGLTGS*A
SVCG*SSMAASGGTGGWTPVLHRPCGADNVFI*G
RVPQRLHL*RTYRGRTAVWGSGPAGRWCGGAG*
L*EESGAAGLARL*LCGMEQPQLLQWLCGDGV*
V*PAEGLPGYAGPL*QHAHAGSPSAWRGGMSLPA
WPCHGLGGGAHAPQPRGQPGGPQSPGCLSAPWR
PCGSLSAVPLPLCGALVTLQRNLLHL*CGEQFL
SGTGRHLPASPLVAAWPTSHQLQQLGAGAQRPAA
RGQGRGEPDRHPHRLPGGHHPAPAAHHCPHALA
AALAQAPQQGPREPPPYQEPRPRGNPPHSAPCV
PNGSALLLSNPAYRLLLATYARPPRGPGPPTPAW
AKPTNTQGRHRGQHLCCACTAPRGSRGWAPQSG
FPSISTPLQGEAWRGPVWGGAPV*GRQPSRSG*
S*FPP*CA*GTPFAGSCQDLTARCHQECQE*FPE
RGEDHVEAQGPKHHSAAGRVCAGRPPLHDY*LH
GERRPQPVPQCPPAGGQGSRGGPWGRAGCAGAH
HQLPNAAACGSPDRLRHALSGHTQLCTFLGGETQ
IFTLIYGPSLRQF*SPALGR***RLSFPQLCEW
VPWEFGNSASCTSL*THFPTHFPSSFFPASSFH
FPSPVLPSIVFCFWIIQAFACGTSGDA*MSECMN
LLNSEGCSGGGLEGMQSGQGC*TFFVP*TPLAV
CRGLLSPPQN*VLKPIKWTRHSGSPL*SQHFGR
LRWVDHLRPGVRDQPGQHSKTPSLLKIQKLAGCG
GMRL*SQLFRRLRQENCLEPGRWGLQ*AEITQL
CSSLGNRVRLSQKQNNNNNKTHKMYRIIRETNG
NSLPKC*KIMKLMCFFFMYLITRSKNRCNKLTFS
KY

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