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Sequences

Sequence DDR1.gAug05

GCCCCAGCCCTGGCTCCTCTCCCCGGAACAGGCCCCCGACAGCTGCTCTCGGGAGCCGCCTCCCGACACCCGAGCCCCGCCGGCGCCTCCCGCTCCCGGC TCCCGGCTCCTGGCTCCCTCCGCCTCCCCCGCCCCTCGCCCCGCCGCCGAAGAGGCCCCGCTCCCGGGTCGGACGCCTGGGTCTGCCGGGAAGAGCGATG AGAGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGA GATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCT CCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGA GTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTAC CGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGC TGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTG CCTCTGGAGGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACAT ACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAG GCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGT CCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATG CGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCT TTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTG GTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATC CTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAAC GGAGGGTGTTGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCA GGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCGCC CCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGTGC CTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGG GGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAG ATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGG GCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGC AGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGC TATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGGCATGAGCC GGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAGTTCACGAC TGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGGTCATCGAG AACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCGGTGCTGGA GCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCTGCCCCTCC CTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCTAATAGAGG CAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTCCTTCCTAG AAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAGGATAGACA CTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCACACACTGGA CCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGCTTCTTCCT CCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTTCTCTAAGC CTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGCCACATTGA TTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGC ACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCAC TTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGG CCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTC AGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAA TGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAAC ATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTG CTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAAC AACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCA TGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F17 (forward primer)
DDR1.R9 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

APALAPLPGTGPRQLLSGAASRHPSPAGASRSR LPAPGSLRLPRPSPRRRRGPAPGSDAWVCREER* ERCCPHPLRPEGSGAMGPEALSSLLLLLLVASG DADMKGHFDPAKCRYALGMQDRTIPDSDISASS SWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEE YLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSY RLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVV LKDLGPPMVARLVRFYPRADRVMSVCLRVELYGC LWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGH TVGGLQYGGLGQLADGVVGLDDFRKSQELRVWP GYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQV HCNNMHTLGARLPGGVECRFRRGPAMAWEGEPM RHNLGGNLGDPRARAVSVPLGGRVARFLQCRFL FAGPWLLFSEISFISDVVNNSSPALGGTFPPAPW WPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAE RRVLEEELTVHLSVPGDTILINNRPGPREPPPYQ EPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGA PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAV PALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFG EVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVK ILRPDATKNARNDFLKEVKIMSRLKDPNIIRLL GVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMR YLATLNFVHRDLATRNCLVGENFTIKIADFGMS RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT ASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIE NAGEFFRDQGRQVYLSRPPACPQGLYELMLRCW SRESEQRPPFSQLHRFLAEDALNTV*ITHPAAPP SGSDPGEASDTKTRGHNGTSALPLPTAHHL**R Q*DCRWAGPTQGADAPSPLPGHTLMSPSCSSFL EAPVAHPAGPVDGILSTLL*PSLGEGWGEI*DRH WTWPIGAPGPHWTTLIPGEVAAPPASLSLSHTG PHWLRIWG*GGQEGEENVSLCLLLYLSSAWASS SSIT*NTGPGGSPAPALSHPHFPLAVL*LELL*A YTFLWSKYWDWGERGSNGP*PWGWTSLV*LPH* FFYNHLGFVHFWGERHRFLH*YMDLA*GNFNPL H*AGNNKG*VFHNCVSGFLGNLVTLPPAPPSEPT SQPTSHLPFFLPPHSISHHLFCPALCSVSG*SR PLPVGPQEMHECLSA*TFSTQRGALVEAWKECS QARGAEPFLCHKRLWQSVEVY*VLLRIRF*NL*N GPGIVAHPCNPSTLGG*GG*IT*GQEFETNLAN IAKPHLY*RYKN*QGVVACACNLSYSGG*GRRI A*NPGGGGCSELRSHNCAPAWATE*DCLKNRTTT TTKPIKCIGL*GKPMETVYQNAKKL*N*CASFS CI**QDLKTGVIN*HFPNT

Frame 1

PQPWLLSPEQAPDSCSREPPPDTRAPPAPPAPG SRLLAPSASPAPRPAAEEAPLPGRTPGSAGKSD ERDAAPTPLGPRDQELWDQRPCHLYCCCSWWQVE MLT*RDILILPSAAMPWACRTGPSQTVTSLLPA PGQIPLPPATAGWRAVTGMGPGAPQGRCFPRRR STCRWIYNDCTWWLWWAPRDGMPGAWARSSPGAT GCVTPGMVAAGWAGRTAGVRR*SQAMRTLREWC *RTLGPPWLPDWFASTPGLTGS*ASVCG*SSMA ASGGMDSCLTPPLWGRQCIYLRPCTSTTPPMTDI PWADCSMGVWASWQMVWWGWMTLGRVRSCGSGQ AMTMWDGATTASPVAMWRWSLSLTG*GPSRLCR STVTTCTRWEPVCLAGWNVASGVALPWPGRGSPC ATT*GATWGTPEPGLSQCPLAAVWLAFCSAASS LRGPGYSSAKSPSSLMW*TIPLRHWEAPSRQPP GGRLAHLPPTSAAWSWSPEASSPWPRPRGARPPS SSAAWWPSSCSCCSSLPSCSGGCTGAGSSARLN GGCWKRS*RFTSLSLGTLSSSTTAQVLESHPRT RSPGLVGIRPTPLPVSPMALPTVGTIWSLRSQAP RFCPHLPRTASPIMPRLTLLPCRASPGATPMLC LHCPQGQSGMGPPEWISLDLDSASRRSLARASL GRCTCVRSTALKIWLVLISPLMCVRDTLCW*LSR SYGQMPPRMPGMIS*KR*RSCRGSRTQTSFGCW ACVCRTTPSA*LLTTWRTATSTSSSVPTSWRTR QPRGPLGTGRLRRGPPSATQCCCMWQPRSPPACA IWPHSTLYIGTWPRGTA*LGKISPSKSQTLA*A GTSMLGTITVCRAGQCCPSAGWPGSASSWGSSR LRVTCGPLV*PCGRC*CSVGPSPLGSSPTSRSSR TRGSSSGTRAGRCTCPGRLPARRAYMS*CFGAG AGSLSSDHPFPSCIGSWQRMHSTRCESHIQLPL PQGAIQGKPVTLKQEDTMAPLPFPSRQPITSNRG SETAGGLGPPRELMPLLPFLDTLSCPLPVLPS* KPLSPTQLVLWMGSSPPSSSHPLGKGGEKYRID TGHGPLEHLGPTGQH*FLERWLRPQLLSPCHTLD PTG*ESGGEEDKKERKMFPCACSCTCPQLGLLP PPSPETLDLGVAPPQPSVTPTSHLQSCS*NFSK PIRFCGVNIGIGGKEGATAHSLGVGHL*CSCHID FSIITWGLYIFGGRDTDFYTNIWT*LEAILIPC TRQVIIKVEFSTTV*VGSLGIW*LCLLHLPLNP LPNPLPIFLFSCLLIPFPITCFAQHCVLFLDNPG LCLWDLRRCMNV*VHEPSQLRGVLWWRPGRNAV RPGVLNLFCAINAFGSL*RSTESSSELGFKTYK MDQA*WLTPVIPALWEAEVGRSLEARSSRPTWPT *QNPISTKDTKISRVWWHAPVISAIQEAEAGEL LRTREVGVAVS*DHTTVLQPGQQSETVSKTEQQ QQQNP*NV*DYKGNQWKQFTKMLKNYETNVLLFH VFNNKI*KQV**TDIFQIL

Frame 2

PSPGSSPRNRPPTAALGSRLPTPEPRRRLPLPA PGSWLPPPPPPLAPPPKRPRSRVGRLGLPGRAM REMLPPPP*ARGIRSYGTRGPVIFTAAALGGKW RC*HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQL LVRFHCRPPQQVGEQ*RGWGLVPRRVGVSQGGG VLAGGSTTTAPGGSGGHPGTACRGPGQGVLPEL PAALLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGA EGPWAPHGCPTGSLLPPG*PGHERLSAGRALWL PLEGWTPVLHRPCGADNVFI*GRVPQRLHL*RT YRGRTAVWGSGPAGRWCGGAG*L*EESGAAGLAR L*LCGMEQPQLLQWLCGDGV*V*PAEGLPGYAG PL*QHAHAGSPSAWRGGMSLPAWPCHGLGGGAH APQPRGQPGGPQSPGCLSAPWRPCGSLSAVPLPL CGALVTLQRNLLHL*CGEQFLSGTGRHLPASPL VAAWPTSHQLQQLGAGAQRPAARGQGRGEPDRH PHRLPGGHHPAPAAHHCPHALAAALAQAPQQG*T EGVGRGADGSPLCPWGHYPHQQPPRS*RATPVP GAPASWESAPLRSLCPQWLCLQWGLYGA*EARR PASAPTSPEQRPPLCRG*HCYPAGRHRGQHLCCA CTAPRGSRGWAPQSGFPSISTPLQGEAWRGPVW GGAPV*GRQPSRSG*S*FPP*CA*GTPFAGSCQ DLTARCHQECQE*FPERGEDHVEAQGPKHHSAAG RVCAGRPPLHDY*LHGERRPQPVPQCPPAGGQG SRGGPWGRAGCAGAHHQLPNAAACGSPDRLRHA LSGHTQLCTSGPGHAELPSWGKFHHQNRRLWHEP EPLCWGLLPCAGPGSAAHPLDGLGVHPHGEVHD CE*RVGLWCDPVGGADAL*GPALWAAHRRAGHR ERGGVLPGPGPAGVPVPAACLPAGPI*ADASVLE PGV*AATTLFPAASVPGRGCTQHGVNHTSSCPS LRERSRGSQ*H*NKRTQWHLCPSPPDSPSPLIE AVRLQVGWAHPGS*CPFSPSWTHSHVPFLFFLPR SPCRPPSWSCGWDPLHPPLAIPWGRVGRNIG*T LDMAHWSTWAPLDNTDSWRGGCAPSFSLPVTHW TPLAENLGVRRTRRRGKCFLVPAPVLVLSLGFFL LHHLKHWTWG*PRPSPQSPPLPTCSLVARTSLS LYVSVE*ILGLGGKREQRPIALGLDISSVAATL IFL*SLGVCTFLGGETQIFTLIYGPSLRQF*SPA LGR***RLSFPQLCEWVPWEFGNSASCTSL*TH FPTHFPSSFFPASSFHFPSPVLPSIVFCFWIIQ AFACGTSGDA*MSECMNLLNSEGCSGGGLEGMQS GQGC*TFFVP*TPLAVCRGLLSPPQN*VLKPIK WTRHSGSPL*SQHFGRLRWVDHLRPGVRDQPGQ HSKTPSLLKIQKLAGCGGMRL*SQLFRRLRQENC LEPGRWGLQ*AEITQLCSSLGNRVRLSQKQNNN NNKTHKMYRIIRETNGNSLPKC*KIMKLMCFFF MYLITRSKNRCNKLTFSKY

Sequence DDR1.fAug05

GATCCCAGAAGTAGGAGGGGCGTCTTCCCCTCGTGGGCCCTGAGCGGGACTGCAGCCAGCCCCCTGGGGCGCCAGCTTTGGAGGCCCCCGACAGCTGCTC TCGGGAGCCGCCTCCCGACACCCGAGCCCCGCCGGCGCCTCCCGCTCCCGGCTCCCGGCTCCTGGCTCCCTCCGCCTCCCCCGCCCCTCGCCCCGCCGCC GAAGAGGCCCCGCTCCCGGGTCGGACGCCTGGGTCTGCCGGGAAGAGCGATGAGAGGTGTCTGAAGGTGGCTATTCACTGAGCGATGGGGTTGGACTTGA AGGAATGCCAAGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGG CAAGTGGAGATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGC TTCCAGCTCCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAG GAGGAGGAGTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCC GGAGCTACCGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGG AGTGGTGCTGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTC TATGGCTGCCTCTGGAGGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATG ACGGACATACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGT CTGGCCAGGCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCT ATGCAGGTCCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGG AGCCCATGCGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCG CTTCCTCTTTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCA GCCCCCTGGTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGA CCGCCATCCTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAA GGCTGAACGGAGGGTGTTGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCC CCGTACCAGGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCCTACAGTGGGGACTATATGGAGCCTGAGAAGC CAGGCGCCCCGCTTCTGCCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTA TGCTGTGCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGC CAGTTTGGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAG CTGTCAAGATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCG GCTGCTGGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAG GACAAGGCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCG GCATGCGCTATCTGGCCACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGG CATGAGCCGGAACCTCTATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAG TTCACGACTGCGAGTGACGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGG TCATCGAGAACGCGGGGGAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCG GTGCTGGAGCCGGGAGTCTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCT GCCCCTCCCTCAGGGAGCGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCT AATAGAGGCAGTGAGACTGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTC CTTCCTAGAAGCCCCTGTCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAG GATAGACACTGGACATGGCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCAC ACACTGGACCCCACTGGCTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGC TTCTTCCTCCTCCATCACCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTT CTCTAAGCCTATACGTTTCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGC CACATTGATTTTTCTATAATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAA TCCCCTGCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCT GAACCCACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGAT AATCCAGGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGA ATGCAGTCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAAC CTATAAAATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACC TGGCCAACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAG GAGAATTGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGA ACAACAACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTT CTTTTTCATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F17 (forward primer)
DDR1.R9 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

DPRSRRGVFPSWALSGTAASPLGRQLWRPPTAA LGSRLPTPEPRRRLPLPAPGSWLPPPPPPLAPPP KRPRSRVGRLGLPGRAMRGV*RWLFTERWGWT* RNAKRCCPHPLRPEGSGAMGPEALSSLLLLLLV ASGDADMKGHFDPAKCRYALGMQDRTIPDSDISA SSSWSDSTAARHSRLESSDGDGAWCPAGSVFPK EEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFS RSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEG VVLKDLGPPMVARLVRFYPRADRVMSVCLRVEL YGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTY DGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRV WPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQA MQVHCNNMHTLGARLPGGVECRFRRGPAMAWEG EPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCR FLFAGPWLLFSEISFISDVVNNSSPALGGTFPP APWWPPGPPPTNFSSLELEPRGQQPVAKAEGSP TAILIGCLVAIILLLLLIIALMLWRLHWRRLLSK AERRVLEEELTVHLSVPGDTILINNRPGPREPP PYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEK PGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTY AVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEG QFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIR LLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIAS GMRYLATLNFVHRDLATRNCLVGENFTIKIADFG MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQ VIENAGEFFRDQGRQVYLSRPPACPQGLYELMLR CWSRESEQRPPFSQLHRFLAEDALNTV*ITHPA APPSGSDPGEASDTKTRGHNGTSALPLPTAHHL **RQ*DCRWAGPTQGADAPSPLPGHTLMSPSCSS FLEAPVAHPAGPVDGILSTLL*PSLGEGWGEI* DRHWTWPIGAPGPHWTTLIPGEVAAPPASLSLS HTGPHWLRIWG*GGQEGEENVSLCLLLYLSSAWA SSSSIT*NTGPGGSPAPALSHPHFPLAVL*LEL L*AYTFLWSKYWDWGERGSNGP*PWGWTSLV*L PH*FFYNHLGFVHFWGERHRFLH*YMDLA*GNFN PLH*AGNNKG*VFHNCVSGFLGNLVTLPPAPPS EPTSQPTSHLPFFLPPHSISHHLFCPALCSVSG *SRPLPVGPQEMHECLSA*TFSTQRGALVEAWKE CSQARGAEPFLCHKRLWQSVEVY*VLLRIRF*N L*NGPGIVAHPCNPSTLGG*GG*IT*GQEFETN LANIAKPHLY*RYKN*QGVVACACNLSYSGG*GR RIA*NPGGGGCSELRSHNCAPAWATE*DCLKNR TTTTTKPIKCIGL*GKPMETVYQNAKKL*N*CA SFSCI**QDLKTGVIN*HFPNT

Frame 1

IPEVGGASSPRGP*AGLQPAPWGASFGGPRQLL SGAASRHPSPAGASRSRLPAPGSLRLPRPSPRR RRGPAPGSDAWVCREER*EVSEGGYSLSDGVGLE GMPRDAAPTPLGPRDQELWDQRPCHLYCCCSWW QVEMLT*RDILILPSAAMPWACRTGPSQTVTSL LPAPGQIPLPPATAGWRAVTGMGPGAPQGRCFPR RRSTCRWIYNDCTWWLWWAPRDGMPGAWARSSP GATGCVTPGMVAAGWAGRTAGVRR*SQAMRTLR EWC*RTLGPPWLPDWFASTPGLTGS*ASVCG*SS MAASGGMDSCLTPPLWGRQCIYLRPCTSTTPPM TDIPWADCSMGVWASWQMVWWGWMTLGRVRSCG SGQAMTMWDGATTASPVAMWRWSLSLTG*GPSRL CRSTVTTCTRWEPVCLAGWNVASGVALPWPGRG SPCATT*GATWGTPEPGLSQCPLAAVWLAFCSA ASSLRGPGYSSAKSPSSLMW*TIPLRHWEAPSRQ PPGGRLAHLPPTSAAWSWSPEASSPWPRPRGAR PPSSSAAWWPSSCSCCSSLPSCSGGCTGAGSSA RLNGGCWKRS*RFTSLSLGTLSSSTTAQVLESHP RTRSPGLVGIRPTPLPVSPMALPTVGTIWSLRS QAPRFCPHLPRTASPIMPRLTLLPCRASPGATP MLCLHCPQGQSGMGPPEWISLDLDSASRRSLARA SLGRCTCVRSTALKIWLVLISPLMCVRDTLCW* LSRSYGQMPPRMPGMIS*KR*RSCRGSRTQTSF GCWACVCRTTPSA*LLTTWRTATSTSSSVPTSWR TRQPRGPLGTGRLRRGPPSATQCCCMWQPRSPP ACAIWPHSTLYIGTWPRGTA*LGKISPSKSQTL A*AGTSMLGTITVCRAGQCCPSAGWPGSASSWGS SRLRVTCGPLV*PCGRC*CSVGPSPLGSSPTSR SSRTRGSSSGTRAGRCTCPGRLPARRAYMS*CF GAGAGSLSSDHPFPSCIGSWQRMHSTRCESHIQL PLPQGAIQGKPVTLKQEDTMAPLPFPSRQPITS NRGSETAGGLGPPRELMPLLPFLDTLSCPLPVL PS*KPLSPTQLVLWMGSSPPSSSHPLGKGGEKYR IDTGHGPLEHLGPTGQH*FLERWLRPQLLSPCH TLDPTG*ESGGEEDKKERKMFPCACSCTCPQLG LLPPPSPETLDLGVAPPQPSVTPTSHLQSCS*NF SKPIRFCGVNIGIGGKEGATAHSLGVGHL*CSC HIDFSIITWGLYIFGGRDTDFYTNIWT*LEAIL IPCTRQVIIKVEFSTTV*VGSLGIW*LCLLHLPL NPLPNPLPIFLFSCLLIPFPITCFAQHCVLFLD NPGLCLWDLRRCMNV*VHEPSQLRGVLWWRPGR NAVRPGVLNLFCAINAFGSL*RSTESSSELGFKT YKMDQA*WLTPVIPALWEAEVGRSLEARSSRPT WPT*QNPISTKDTKISRVWWHAPVISAIQEAEA GELLRTREVGVAVS*DHTTVLQPGQQSETVSKTE QQQQQNP*NV*DYKGNQWKQFTKMLKNYETNVL LFHVFNNKI*KQV**TDIFQIL

Frame 2

SQK*EGRLPLVGPERDCSQPPGAPALEAPDSCS REPPPDTRAPPAPPAPGSRLLAPSASPAPRPAA EEAPLPGRTPGSAGKSDERCLKVAIH*AMGLDL KECQEMLPPPP*ARGIRSYGTRGPVIFTAAALGG KWRC*HEGTF*SCQVPLCPGHAGPDHPRQ*HLC FQLLVRFHCRPPQQVGEQ*RGWGLVPRRVGVSQ GGGVLAGGSTTTAPGGSGGHPGTACRGPGQGVLP ELPAALLPGWSPLDGLEGPLGSGGDLRQ*GP*G SGAEGPWAPHGCPTGSLLPPG*PGHERLSAGRA LWLPLEGWTPVLHRPCGADNVFI*GRVPQRLHL* RTYRGRTAVWGSGPAGRWCGGAG*L*EESGAAG LARL*LCGMEQPQLLQWLCGDGV*V*PAEGLPG YAGPL*QHAHAGSPSAWRGGMSLPAWPCHGLGGG AHAPQPRGQPGGPQSPGCLSAPWRPCGSLSAVP LPLCGALVTLQRNLLHL*CGEQFLSGTGRHLPA SPLVAAWPTSHQLQQLGAGAQRPAARGQGRGEPD RHPHRLPGGHHPAPAAHHCPHALAAALAQAPQQ G*TEGVGRGADGSPLCPWGHYPHQQPPRS*RAT PVPGAPASWESAPLRSLCPQWLCLQWGLYGA*EA RRPASAPTSPEQRPPLCRG*HCYPAGRHRGQHL CCACTAPRGSRGWAPQSGFPSISTPLQGEAWRG PVWGGAPV*GRQPSRSG*S*FPP*CA*GTPFAGS CQDLTARCHQECQE*FPERGEDHVEAQGPKHHS AAGRVCAGRPPLHDY*LHGERRPQPVPQCPPAG GQGSRGGPWGRAGCAGAHHQLPNAAACGSPDRLR HALSGHTQLCTSGPGHAELPSWGKFHHQNRRLW HEPEPLCWGLLPCAGPGSAAHPLDGLGVHPHGE VHDCE*RVGLWCDPVGGADAL*GPALWAAHRRAG HRERGGVLPGPGPAGVPVPAACLPAGPI*ADAS VLEPGV*AATTLFPAASVPGRGCTQHGVNHTSS CPSLRERSRGSQ*H*NKRTQWHLCPSPPDSPSPL IEAVRLQVGWAHPGS*CPFSPSWTHSHVPFLFF LPRSPCRPPSWSCGWDPLHPPLAIPWGRVGRNI G*TLDMAHWSTWAPLDNTDSWRGGCAPSFSLPVT HWTPLAENLGVRRTRRRGKCFLVPAPVLVLSLG FFLLHHLKHWTWG*PRPSPQSPPLPTCSLVART SLSLYVSVE*ILGLGGKREQRPIALGLDISSVAA TLIFL*SLGVCTFLGGETQIFTLIYGPSLRQF* SPALGR***RLSFPQLCEWVPWEFGNSASCTSL *THFPTHFPSSFFPASSFHFPSPVLPSIVFCFWI IQAFACGTSGDA*MSECMNLLNSEGCSGGGLEG MQSGQGC*TFFVP*TPLAVCRGLLSPPQN*VLK PIKWTRHSGSPL*SQHFGRLRWVDHLRPGVRDQP GQHSKTPSLLKIQKLAGCGGMRL*SQLFRRLRQ ENCLEPGRWGLQ*AEITQLCSSLGNRVRLSQKQ NNNNNKTHKMYRIIRETNGNSLPKC*KIMKLMCF FFMYLITRSKNRCNKLTFSKY

Sequence DDR1.eAug05

TTAGGAAGTTATTTAACTGATCTCTGCCCTAGTTTCTTCATGTGTTAAATATGGATAGTAATAGTATCTACCTTATGAAGTGACTGTGAAGATAAAATTA TGGATTCTGTTTAAGGGTTTAGGCCAGTGTCTGGCACAGGGGAAGCATTCTAAAAATATAGCTGATGCTGTTAAACAATGACTGTTGTTGTTGTTTTACT GTTATTATCCCCAAAGCGGCCCATTCTGTCTGTTGCTGTCAGCTATGACTCAGTCCCCTGATTAACTTACGCACCACCCATTTTATCCCCTGCAGAGATG CTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTACTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGAC ATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCCCAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAG ATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGCAGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCA GGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGCCTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGT TACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAGGCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACC TTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGTCTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAG GGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGGCCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGC GGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGACTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACT ATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAA CAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGCGTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAAC CTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGGCCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGC CCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCTCCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCC TGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGCCCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGC TGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGGCTGAACGGAGGGTGT TGGAAGAGGAGCTGACGGTTCACCTCTCTGTCCCTGGGGACACTATCCTCATCAACAACCGCCCAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCG GCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCCCCAATGGCTCTGCCTACAGTGGGGACTATATGGAGCCTGAGAAGCCAGGCGCCCCGCTTCTG CCCCCACCTCCCCAGAACAGCGTCCCCCATTATGCCGAGGCTGACATTGTTACCCTGCAGGGCGTCACCGGGGGCAACACCTATGCTGTGCCTGCACTGC CCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGATTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGGGGAGGTGCA CCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGTCTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAGATCTTACGG CCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGAAAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGGGCGTGTGTG TGCAGGACGACCCCCTCTGCATGATTACTGACTACATGGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGCAGCCGAGGG GGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACCATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGCTATCTGGCC ACACTCAACTTTGTACATCGGGACCTGGCCACGCGGAACTGCCTAGTTGGGGAAAATTTCACCATCAAAATCGCAGACTTTGGCATGAGCCGGAACCTCT ATGCTGGGGACTATTACCGTGTGCAGGGCCGGGCAGTGCTGCCCATCCGCTGGATGGCCTGGGAGTGCATCCTCATGGGGAAGTTCACGACTGCGAGTGA CGTGTGGGCCTTTGGTGTGACCCTGTGGGAGGTGCTGATGCTCTGTAGGGCCCAGCCCTTTGGGCAGCTCACCGACGAGCAGGTCATCGAGAACGCGGGG GAGTTCTTCCGGGACCAGGGCCGGCAGGTGTACCTGTCCCGGCCGCCTGCCTGCCCGCAGGGCCTATATGAGCTGATGCTTCGGTGCTGGAGCCGGGAGT CTGAGCAGCGACCACCCTTTTCCCAGCTGCATCGGTTCCTGGCAGAGGATGCACTCAACACGGTGTGAATCACACATCCAGCTGCCCCTCCCTCAGGGAG CGATCCAGGGGAAGCCAGTGACACTAAAACAAGAGGACACAATGGCACCTCTGCCCTTCCCCTCCCGACAGCCCATCACCTCTAATAGAGGCAGTGAGAC TGCAGGTGGGCTGGGCCCACCCAGGGAGCTGATGCCCCTTCTCCCCTTCCTGGACACACTCTCATGTCCCCTTCCTGTTCTTCCTTCCTAGAAGCCCCTG TCGCCCACCCAGCTGGTCCTGTGGATGGGATCCTCTCCACCCTCCTCTAGCCATCCCTTGGGGAAGGGTGGGGAGAAATATAGGATAGACACTGGACATG GCCCATTGGAGCACCTGGGCCCCACTGGACAACACTGATTCCTGGAGAGGTGGCTGCGCCCCCAGCTTCTCTCTCCCTGTCACACACTGGACCCCACTGG CTGAGAATCTGGGGGTGAGGAGGACAAGAAGGAGAGGAAAATGTTTCCTTGTGCCTGCTCCTGTACTTGTCCTCAGCTTGGGCTTCTTCCTCCTCCATCA CCTGAAACACTGGACCTGGGGGTAGCCCCGCCCCAGCCCTCAGTCACCCCCACTTCCCACTTGCAGTCTTGTAGCTAGAACTTCTCTAAGCCTATACGTT TCTGTGGAGTAAATATTGGGATTGGGGGGAAAGAGGGAGCAACGGCCCATAGCCTTGGGGTTGGACATCTCTAGTGTAGCTGCCACATTGATTTTTCTAT AATCACTTGGGGTTTGTACATTTTTGGGGGGAGAGACACAGATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGCACTAGGCAG GTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGGGTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCACTTCCCAACC CACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATTTCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGGCCTTTGCCT GTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAACCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTCAGGCCAGGG GTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTCTGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAATGGACCAGG CATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATAGCAAAA CCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGGTGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTGCTTAGAACC CGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTGTGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAACAACAACAAA ACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAAACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCATGTATTTAA TAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTCCAAATACTA

DDR1.F17 (forward primer)
DDR1.R9 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

LGSYLTDLCPSFFMC*IWIVIVSTL*SDCEDKI MDSV*GFRPVSGTGEAF*KYS*CC*TMTVVVVLL LLSPKRPILSVAVSYDSVP*LTYAPPILSPAEM LPPPP*ARGIRSYGTRGPVIFTAAALGGKWRC* HEGTF*SCQVPLCPGHAGPDHPRQ*HLCFQLLVR FHCRPPQQVGEQ*RGWGLVPRRVGVSQGGGVLA GGSTTTAPGGSGGHPGTACRGPGQGVLPELPAA LLPGWSPLDGLEGPLGSGGDLRQ*GP*GSGAEGP WAPHGCPTGSLLPPG*PGHERLSAGRALWLPLE GWTPVLHRPCGADNVFI*GRVPQRLHL*RTYRG RTAVWGSGPAGRWCGGAG*L*EESGAAGLARL*L CGMEQPQLLQWLCGDGV*V*PAEGLPGYAGPL* QHAHAGSPSAWRGGMSLPAWPCHGLGGGAHAPQ PRGQPGGPQSPGCLSAPWRPCGSLSAVPLPLCGA LVTLQRNLLHL*CGEQFLSGTGRHLPASPLVAA WPTSHQLQQLGAGAQRPAARGQGRGEPDRHPHR LPGGHHPAPAAHHCPHALAAALAQAPQQG*TEGV GRGADGSPLCPWGHYPHQQPPRS*RATPVPGAP ASWESAPLRSLCPQWLCLQWGLYGA*EARRPAS APTSPEQRPPLCRG*HCYPAGRHRGQHLCCACTA PRGSRGWAPQSGFPSISTPLQGEAWRGPVWGGA PV*GRQPSRSG*S*FPP*CA*GTPFAGSCQDLT ARCHQECQE*FPERGEDHVEAQGPKHHSAAGRVC AGRPPLHDY*LHGERRPQPVPQCPPAGGQGSRG GPWGRAGCAGAHHQLPNAAACGSPDRLRHALSG HTQLCTSGPGHAELPSWGKFHHQNRRLWHEPEPL CWGLLPCAGPGSAAHPLDGLGVHPHGEVHDCE* RVGLWCDPVGGADAL*GPALWAAHRRAGHRERG GVLPGPGPAGVPVPAACLPAGPI*ADASVLEPGV *AATTLFPAASVPGRGCTQHGVNHTSSCPSLRE RSRGSQ*H*NKRTQWHLCPSPPDSPSPLIEAVR LQVGWAHPGS*CPFSPSWTHSHVPFLFFLPRSPC RPPSWSCGWDPLHPPLAIPWGRVGRNIG*TLDM AHWSTWAPLDNTDSWRGGCAPSFSLPVTHWTPL AENLGVRRTRRRGKCFLVPAPVLVLSLGFFLLHH LKHWTWG*PRPSPQSPPLPTCSLVARTSLSLYV SVE*ILGLGGKREQRPIALGLDISSVAATLIFL *SLGVCTFLGGETQIFTLIYGPSLRQF*SPALGR ***RLSFPQLCEWVPWEFGNSASCTSL*THFPT HFPSSFFPASSFHFPSPVLPSIVFCFWIIQAFA CGTSGDA*MSECMNLLNSEGCSGGGLEGMQSGQG C*TFFVP*TPLAVCRGLLSPPQN*VLKPIKWTR HSGSPL*SQHFGRLRWVDHLRPGVRDQPGQHSK TPSLLKIQKLAGCGGMRL*SQLFRRLRQENCLEP GRWGLQ*AEITQLCSSLGNRVRLSQKQNNNNNK THKMYRIIRETNGNSLPKC*KIMKLMCFFFMYL ITRSKNRCNKLTFSKY

Frame 1

*EVI*LISALVSSCVKYG***YLPYEVTVKIKL WILFKGLGQCLAQGKHSKNIADAVKQ*LLLLFY CYYPQSGPFCLLLSAMTQSPD*LTHHPFYPLQRC CPHPLRPEGSGAMGPEALSSLLLLLLVASGDAD MKGHFDPAKCRYALGMQDRTIPDSDISASSSWS DSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQ VDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKD LGPPMVARLVRFYPRADRVMSVCLRVELYGCLWR DGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVG GLQYGGLGQLADGVVGLDDFRKSQELRVWPGYD YVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCN NMHTLGARLPGGVECRFRRGPAMAWEGEPMRHN LGGNLGDPRARAVSVPLGGRVARFLQCRFLFAG PWLLFSEISFISDVVNNSSPALGGTFPPAPWWPP GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIG CLVAIILLLLLIIALMLWRLHWRRLLSKAERRV LEEELTVHLSVPGDTILINNRPGPREPPPYQEPR PRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLL PPPPQNSVPHYAEADIVTLQGVTGGNTYAVPAL PPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVH LCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC VQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEG APGDGQAAQGPTISYPMLLHVAAQIASGMRYLA TLNFVHRDLATRNCLVGENFTIKIADFGMSRNL YAGDYYRVQGRAVLPIRWMAWECILMGKFTTASD VWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAG EFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE SEQRPPFSQLHRFLAEDALNTV*ITHPAAPPSGS DPGEASDTKTRGHNGTSALPLPTAHHL**RQ*D CRWAGPTQGADAPSPLPGHTLMSPSCSSFLEAP VAHPAGPVDGILSTLL*PSLGEGWGEI*DRHWTW PIGAPGPHWTTLIPGEVAAPPASLSLSHTGPHW LRIWG*GGQEGEENVSLCLLLYLSSAWASSSSI T*NTGPGGSPAPALSHPHFPLAVL*LELL*AYTF LWSKYWDWGERGSNGP*PWGWTSLV*LPH*FFY NHLGFVHFWGERHRFLH*YMDLA*GNFNPLH*A GNNKG*VFHNCVSGFLGNLVTLPPAPPSEPTSQP TSHLPFFLPPHSISHHLFCPALCSVSG*SRPLP VGPQEMHECLSA*TFSTQRGALVEAWKECSQAR GAEPFLCHKRLWQSVEVY*VLLRIRF*NL*NGPG IVAHPCNPSTLGG*GG*IT*GQEFETNLANIAK PHLY*RYKN*QGVVACACNLSYSGG*GRRIA*N PGGGGCSELRSHNCAPAWATE*DCLKNRTTTTTK PIKCIGL*GKPMETVYQNAKKL*N*CASFSCI* *QDLKTGVIN*HFPNT

Frame 2

RKLFN*SLP*FLHVLNMDSNSIYLMK*L*R*NY GFCLRV*ASVWHRGSILKI*LMLLNNDCCCCFT VIIPKAAHSVCCCQL*LSPLINLRTTHFIPCRD AAPTPLGPRDQELWDQRPCHLYCCCSWWQVEMLT *RDILILPSAAMPWACRTGPSQTVTSLLPAPGQ IPLPPATAGWRAVTGMGPGAPQGRCFPRRRSTC RWIYNDCTWWLWWAPRDGMPGAWARSSPGATGCV TPGMVAAGWAGRTAGVRR*SQAMRTLREWC*RT LGPPWLPDWFASTPGLTGS*ASVCG*SSMAASG GMDSCLTPPLWGRQCIYLRPCTSTTPPMTDIPWA DCSMGVWASWQMVWWGWMTLGRVRSCGSGQAMT MWDGATTASPVAMWRWSLSLTG*GPSRLCRSTV TTCTRWEPVCLAGWNVASGVALPWPGRGSPCATT *GATWGTPEPGLSQCPLAAVWLAFCSAASSLRG PGYSSAKSPSSLMW*TIPLRHWEAPSRQPPGGR LAHLPPTSAAWSWSPEASSPWPRPRGARPPSSSA AWWPSSCSCCSSLPSCSGGCTGAGSSARLNGGC WKRS*RFTSLSLGTLSSSTTAQVLESHPRTRSP GLVGIRPTPLPVSPMALPTVGTIWSLRSQAPRFC PHLPRTASPIMPRLTLLPCRASPGATPMLCLHC PQGQSGMGPPEWISLDLDSASRRSLARASLGRC TCVRSTALKIWLVLISPLMCVRDTLCW*LSRSYG QMPPRMPGMIS*KR*RSCRGSRTQTSFGCWACV CRTTPSA*LLTTWRTATSTSSSVPTSWRTRQPR GPLGTGRLRRGPPSATQCCCMWQPRSPPACAIWP HSTLYIGTWPRGTA*LGKISPSKSQTLA*AGTS MLGTITVCRAGQCCPSAGWPGSASSWGSSRLRV TCGPLV*PCGRC*CSVGPSPLGSSPTSRSSRTRG SSSGTRAGRCTCPGRLPARRAYMS*CFGAGAGS LSSDHPFPSCIGSWQRMHSTRCESHIQLPLPQG AIQGKPVTLKQEDTMAPLPFPSRQPITSNRGSET AGGLGPPRELMPLLPFLDTLSCPLPVLPS*KPL SPTQLVLWMGSSPPSSSHPLGKGGEKYRIDTGH GPLEHLGPTGQH*FLERWLRPQLLSPCHTLDPTG *ESGGEEDKKERKMFPCACSCTCPQLGLLPPPS PETLDLGVAPPQPSVTPTSHLQSCS*NFSKPIR FCGVNIGIGGKEGATAHSLGVGHL*CSCHIDFSI ITWGLYIFGGRDTDFYTNIWT*LEAILIPCTRQ VIIKVEFSTTV*VGSLGIW*LCLLHLPLNPLPN PLPIFLFSCLLIPFPITCFAQHCVLFLDNPGLCL WDLRRCMNV*VHEPSQLRGVLWWRPGRNAVRPG VLNLFCAINAFGSL*RSTESSSELGFKTYKMDQ A*WLTPVIPALWEAEVGRSLEARSSRPTWPT*QN PISTKDTKISRVWWHAPVISAIQEAEAGELLRT REVGVAVS*DHTTVLQPGQQSETVSKTEQQQQQ NP*NV*DYKGNQWKQFTKMLKNYETNVLLFHVFN NKI*KQV**TDIFQIL

Sequence DDR1.hAug05

CTAGATTCCCCAGCTGCTGTTCTCTGGAGGGAGATGCTGCCCCCACCCCCTTAGGCCCGAGGGATCAGGAGCTATGGGACCAGAGGCCCTGTCATCTTTA CTGCTGCTGCTCTTGGTGGCAAGTGGAGATGCTGACATGAAGGGACATTTTGATCCTGCCAAGTGCCGCTATGCCCTGGGCATGCAGGACCGGACCATCC CAGACAGTGACATCTCTGCTTCCAGCTCCTGGTCAGATTCCACTGCCGCCCGCCACAGCAGGTTGGAGAGCAGTGACGGGGATGGGGCCTGGTGCCCCGC AGGGTCGGTGTTTCCCAAGGAGGAGGAGTACTTGCAGGTGGATCTACAACGACTGCACCTGGTGGCTCTGGTGGGCACCCAGGGACGGCATGCCGGGGGC CTGGGCAAGGAGTTCTCCCGGAGCTACCGGCTGCGTTACTCCCGGGATGGTCGCCGCTGGATGGGCTGGAAGGACCGCTGGGGTCAGGAGGTGATCTCAG GCAATGAGGACCCTGAGGGAGTGGTGCTGAAGGACCTTGGGCCCCCCATGGTTGCCCGACTGGTTCGCTTCTACCCCCGGGCTGACCGGGTCATGAGCGT CTGTCTGCGGGTAGAGCTCTATGGCTGCCTCTGGAGGGACTGGAGGATGGACTCCTGTCTTACACCGCCCCTGTGGGGCAGACAATGTATTTATCTGAGG CCGTGTACCTCAACGACTCCACCTATGACGGACATACCGTGGGCGGACTGCAGTATGGGGGTCTGGGCCAGCTGGCAGATGGTGTGGTGGGGCTGGATGA CTTTAGGAAGAGTCAGGAGCTGCGGGTCTGGCCAGGCTATGACTATGTGGGATGGAGCAACCACAGCTTCTCCAGTGGCTATGTGGAGATGGAGTTTGAG TTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTCCACTGTAACAACATGCACACGCTGGGAGCCCGTCTGCCTGGCGGGGTGGAATGTCGCTTCCGGC GTGGCCCTGCCATGGCCTGGGAGGGGGAGCCCATGCGCCACAACCTAGGGGGCAACCTGGGGGACCCCAGAGCCCGGGCTGTCTCAGTGCCCCTTGGCGG CCGTGTGGCTCGCTTTCTGCAGTGCCGCTTCCTCTTTGCGGGGCCCTGGTTACTCTTCAGCGAAATCTCCTTCATCTCTGATGTGGTGAACAATTCCTCT CCGGCACTGGGAGGCACCTTCCCGCCAGCCCCCTGGTGGCCGCCTGGCCCACCTCCCACCAACTTCAGCAGCTTGGAGCTGGAGCCCAGAGGCCAGCAGC CCGTGGCCAAGGCCGAGGGGAGCCCGACCGCCATCCTCATCGGCTGCCTGGTGGCCATCATCCTGCTCCTGCTGCTCATCATTGCCCTCATGCTCTGGCG GCTGCACTGGCGCAGGCTCCTCAGCAAGGTCCTAGAGAGCCACCCCCGTACCAGGAGCCCCGGCCTCGTGGGAATCCGCCCCACTCCGCTCCCTGTGTCC CCAATGGCTCTGCGTTGCTGCTCTCCAATCCAGCCTACCGCCTCCTTCTGGCCACTTACGCCCGTCCCCCTCGAGGCCCGGGCCCCCCCACACCCGCCTG GGCCAAACCCACCAACACCCAGGGGCGTCACCGGGGGCAACACCTATGCTGTGCCTGCACTGCCCCCAGGGGCAGTCGGGGATGGGCCCCCCAGAGTGGA TTTCCCTCGATCTCGACTCCGCTTCAAGGAGAAGCTTGGCGAGGGCCAGTTTGGGGAGGTGCACCTGTGTGAGGTCGACAGCCCTCAAGATCTGGTTAGT CTTGATTTCCCCCTTAATGTGCGTAAGGGACACCCTTTGCTGGTAGCTGTCAAGATCTTACGGCCAGATGCCACCAAGAATGCCAGGAATGATTTCCTGA AAGAGGTGAAGATCATGTCGAGGCTCAAGGACCCAAACATCATTCGGCTGCTGGGCGTGTGTGTGCAGGACGACCCCCTCTGCATGATTACTGACTACAT GGAGAACGGCGACCTCAACCAGTTCCTCAGTGCCCACCAGCTGGAGGACAAGGCAGCCGAGGGGGCCCCTGGGGACGGGCAGGCTGCGCAGGGGCCCACC ATCAGCTACCCAATGCTGCTGCATGTGGCAGCCCAGATCGCCTCCGGCATGCGCTATCTGGCCACACTCAACTTTGTACATTTTTGGGGGGAGAGACACA GATTTTTACACTAATATATGGACCTAGCTTGAGGCAATTTTAATCCCCTGCACTAGGCAGGTAATAATAAAGGTTGAGTTTTCCACAACTGTGTGAGTGG GTTCCTTGGGAATTTGGTAACTCTGCCTCCTGCACCTCCCTCTGAACCCACTTCCCAACCCACTTCCCATCTTCCTTTTTTCCTGCCTCCTCATTCCATT TCCCATCACCTGTTTTGCCCAGCATTGTGTTCTGTTTCTGGATAATCCAGGCCTTTGCCTGTGGGACCTCAGGAGATGCATGAATGTCTGAGTGCATGAA CCTTCTCAACTCAGAGGGGTGCTCTGGTGGAGGCCTGGAAGGAATGCAGTCAGGCCAGGGGTGCTGAACCTTTTTTGTGCCATAAACGCCTTTGGCAGTC TGTAGAGGTCTACTGAGTCCTCCTCAGAATTAGGTTTTAAAACCTATAAAATGGACCAGGCATAGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGC TGAGGTGGGTAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATAGCAAAACCCCATCTCTACTAAAGATACAAAAATTAGCAGGGTGTGG TGGCATGCGCCTGTAATCTCAGCTATTCAGGAGGCTGAGGCAGGAGAATTGCTTAGAACCCGGGAGGTGGGGGTTGCAGTGAGCTGAGATCACACAACTG TGCTCCAGCCTGGGCAACAGAGTGAGACTGTCTCAAAAACAGAACAACAACAACAACAAAACCCATAAAATGTATAGGATTATAAGGGAAACCAATGGAA ACAGTTTACCAAAATGCTAAAAAATTATGAAACTAATGTGCTTCTTTTTCATGTATTTAATAACAAGATCTAAAAACAGGTGTAATAAACTGACATTTTC CAAATACTA

DDR1.F17 (forward primer)
DDR1.R9 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

LDSPAAVLWREMLPPPP*ARGIRSYGTRGPVIF TAAALGGKWRC*HEGTF*SCQVPLCPGHAGPDHP RQ*HLCFQLLVRFHCRPPQQVGEQ*RGWGLVPR RVGVSQGGGVLAGGSTTTAPGGSGGHPGTACRG PGQGVLPELPAALLPGWSPLDGLEGPLGSGGDLR Q*GP*GSGAEGPWAPHGCPTGSLLPPG*PGHER LSAGRALWLPLEGLEDGLLSYTAPVGQTMYLSE AVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFE FDRLRAFQAMQVHCNNMHTLGARLPGGVECRFR RGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGG RVARFLQCRFLFAGPWLLFSEISFISDVVNNSS PALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQ PVAKAEGSPTAILIGCLVAIILLLLLIIALMLWR LHWRRLLSKVLESHPRTRSPGLVGIRPTPLPVS PMALRCCSPIQPTASFWPLTPVPLEARAPPHPP GPNPPTPRGVTGGNTYAVPALPPGAVGDGPPRVD FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS LDFPLNVRKGHPLLVAVKILRPDATKNARNDFL KEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYM ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPT ISYPMLLHVAAQIASGMRYLATLNFVHFWGERH RFLH*YMDLA*GNFNPLH*AGNNKG*VFHNCVSG FLGNLVTLPPAPPSEPTSQPTSHLPFFLPPHSI SHHLFCPALCSVSG*SRPLPVGPQEMHECLSA* TFSTQRGALVEAWKECSQARGAEPFLCHKRLWQS VEVY*VLLRIRF*NL*NGPGIVAHPCNPSTLGG *GG*IT*GQEFETNLANIAKPHLY*RYKN*QGV VACACNLSYSGG*GRRIA*NPGGGGCSELRSHNC APAWATE*DCLKNRTTTTTKPIKCIGL*GKPME TVYQNAKKL*N*CASFSCI**QDLKTGVIN*HF PNT

Frame 1

*IPQLLFSGGRCCPHPLRPEGSGAMGPEALSSL LLLLLVASGDADMKGHFDPAKCRYALGMQDRTI PDSDISASSSWSDSTAARHSRLESSDGDGAWCPA GSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGG LGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVIS GNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSV CLRVELYGCLWRDWRMDSCLTPPLWGRQCIYLR PCTSTTPPMTDIPWADCSMGVWASWQMVWWGWM TLGRVRSCGSGQAMTMWDGATTASPVAMWRWSLS LTG*GPSRLCRSTVTTCTRWEPVCLAGWNVASG VALPWPGRGSPCATT*GATWGTPEPGLSQCPLA AVWLAFCSAASSLRGPGYSSAKSPSSLMW*TIPL RHWEAPSRQPPGGRLAHLPPTSAAWSWSPEASS PWPRPRGARPPSSSAAWWPSSCSCCSSLPSCSG GCTGAGSSARS*RATPVPGAPASWESAPLRSLCP QWLCVAALQSSLPPPSGHLRPSPSRPGPPHTRL GQTHQHPGASPGATPMLCLHCPQGQSGMGPPEW ISLDLDSASRRSLARASLGRCTCVRSTALKIWLV LISPLMCVRDTLCW*LSRSYGQMPPRMPGMIS* KR*RSCRGSRTQTSFGCWACVCRTTPSA*LLTT WRTATSTSSSVPTSWRTRQPRGPLGTGRLRRGPP SATQCCCMWQPRSPPACAIWPHSTLYIFGGRDT DFYTNIWT*LEAILIPCTRQVIIKVEFSTTV*V GSLGIW*LCLLHLPLNPLPNPLPIFLFSCLLIPF PITCFAQHCVLFLDNPGLCLWDLRRCMNV*VHE PSQLRGVLWWRPGRNAVRPGVLNLFCAINAFGS L*RSTESSSELGFKTYKMDQA*WLTPVIPALWEA EVGRSLEARSSRPTWPT*QNPISTKDTKISRVW WHAPVISAIQEAEAGELLRTREVGVAVS*DHTT VLQPGQQSETVSKTEQQQQQNP*NV*DYKGNQWK QFTKMLKNYETNVLLFHVFNNKI*KQV**TDIF QIL

Frame 2

RFPSCCSLEGDAAPTPLGPRDQELWDQRPCHLY CCCSWWQVEMLT*RDILILPSAAMPWACRTGPS QTVTSLLPAPGQIPLPPATAGWRAVTGMGPGAP QGRCFPRRRSTCRWIYNDCTWWLWWAPRDGMPGA WARSSPGATGCVTPGMVAAGWAGRTAGVRR*SQ AMRTLREWC*RTLGPPWLPDWFASTPGLTGS*A SVCG*SSMAASGGTGGWTPVLHRPCGADNVFI*G RVPQRLHL*RTYRGRTAVWGSGPAGRWCGGAG* L*EESGAAGLARL*LCGMEQPQLLQWLCGDGV* V*PAEGLPGYAGPL*QHAHAGSPSAWRGGMSLPA WPCHGLGGGAHAPQPRGQPGGPQSPGCLSAPWR PCGSLSAVPLPLCGALVTLQRNLLHL*CGEQFL SGTGRHLPASPLVAAWPTSHQLQQLGAGAQRPAA RGQGRGEPDRHPHRLPGGHHPAPAAHHCPHALA AALAQAPQQGPREPPPYQEPRPRGNPPHSAPCV PNGSALLLSNPAYRLLLATYARPPRGPGPPTPAW AKPTNTQGRHRGQHLCCACTAPRGSRGWAPQSG FPSISTPLQGEAWRGPVWGGAPV*GRQPSRSG* S*FPP*CA*GTPFAGSCQDLTARCHQECQE*FPE RGEDHVEAQGPKHHSAAGRVCAGRPPLHDY*LH GERRPQPVPQCPPAGGQGSRGGPWGRAGCAGAH HQLPNAAACGSPDRLRHALSGHTQLCTFLGGETQ IFTLIYGPSLRQF*SPALGR***RLSFPQLCEW VPWEFGNSASCTSL*THFPTHFPSSFFPASSFH FPSPVLPSIVFCFWIIQAFACGTSGDA*MSECMN LLNSEGCSGGGLEGMQSGQGC*TFFVP*TPLAV CRGLLSPPQN*VLKPIKWTRHSGSPL*SQHFGR LRWVDHLRPGVRDQPGQHSKTPSLLKIQKLAGCG GMRL*SQLFRRLRQENCLEPGRWGLQ*AEITQL CSSLGNRVRLSQKQNNNNNKTHKMYRIIRETNG NSLPKC*KIMKLMCFFFMYLITRSKNRCNKLTFS KY