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Sequences

Sequence DPH1.cAug05

CTGCGCTCTCCGCGTTCTTCCAGCGCTGTCTTTTTAGTACCACATGCGCAGGCAGGTGATGGCGGCGCTGGTCGTATCCGGGGCAGCGGAGCAGGGCGGC CGAGACGGCCCTGGCAGAGGTCGGGCCCCTCGGGGCCGCGTGGCCAATCAGATCCCCCCTGAGATCCTGAAGAACCCTCAGCTGCAGGCAGCAATCCGGG TCCTGCCTTCCAACTACAACTTTGAGATCCCCAAGACCATCTGGAGGATCCAACAAGCCCAGGCCAAGAAGGTGGCCTTGCAAATGCCGGAAGGCCTCCT CCTCTTTGCCTGTACCATTGTGGATATCTTGGAAAGTTCCCATGGACACCTCGGCCCAAGACTTCCGGGTGCTGTACGTCTTTGTGGACATCCGGATAGA CACTACACACCTCCTGGACTCTCTCCGCCTCACCTTTCCCCCAGCCACTGCCCTTGCCCTGGTCAGCACCATTCAGTTTGTGTCGACCTTGCAGGCAGCC GCCCAGGAGCTGAAAGCCGAGTATCGTGTGAGTGTCCCACAGTGCAAGCCCCTGTCCCCTGGAGAGATCCTGGGCTGCACATCCCCCCGACTGTCCAAAG AGGTGGAGGCCGTTGTGTATCTTGGAGATGGCCGCTTCCATCTGGAGTCTGTCATGATTGCCAACCCCAATGTCCCCGCTTACCGGTATGACCCATATAG CAAAGTCCTATCCAGAGAACACTATGACCACCAGCGCATGCAGGCTGCTCGCCAAGAAGCCATAGCCACTGCCCGCTCAGCTAAGTCCTGGGGCCTTATT CTGGGCACTTTGGGCCGCCAGGGCAGTCCTAAGATCCTGGAGCACCTGGAATCTCGACTCCGAGCCTTGGGCCTTTCCTTTGTGAGGCTGCTGCTCTCTG AGATCTTCCCCAGCAAGCTTAGCCTACTTCCTGAGGTGGATGTGTGGGTGCAGGTGGCATGTCCACGTCTCTCCATTGACTGGGGCACAGCCTTCCCCAA GCCGCTGCTGACACCCTATGAGGCGGCCGTGGCTCTGAGGGACATTTCCTGGCAGCAGCCCTACCCGATGGACTTCTACGCTGGCAGCTCCTTGGGGCCC TGGACGGTGAACCACGGCCAGGACCGCCGTCCCCACGCCCCGGGCCGGCCCGCGCGGGGGAAGGTGCAGGAGGGGTCCGCGCGTCCCCCTTCGGCCGTGG CTTGCGAGGACTGCAGCTGCAGGGACGAGAAGGTGGCGCCGCTGGCTCCTTGACGCGCTCCCGGGCCTCAGGGTCCTGCCCTCCGGAGGAGCAGCCTCGA GGCTGGTGGTTTTCAGAGCAGGAGGCCGACGTTTTCTCCGCATTGGAAGAGCCCGCCGTCTGCAGGGGCCTGGAGGAATCACTGGGGATGGTGGCACAGG CACTGAACAGGCTGGGGCCTTTTGACGGCCTTCTTGGTTTCAGCCAAGGGGCTGCGCTAGCAGCCCTTGTGTGTGCCCTGGGCCAGGCAGGCGATCCCCG CTTCCCCTTGCCACGGTTTATCCTCTTGGTGTCTGGTTTCTGTCCCCGGGGCATTGGGTTCAAGGAATCCATCCTGCAAAGGCCCTTGTCATTGCCTTCG CTCCATGTTTTTGGGGACACTGACAAAGTCATCCCCTCTCAGGAGAGTGTGCAACTGGCCAGCCAATTTCCCGGAGCCATCACCCTCACCCACTCTGGTG GCCACTTCATTCCAGCAGCTGCACCCCAGCGTCAGGCCTACCTCAAGTTCTTGGACCAGTTTGCAGAGTGAAAGATCAAGAAATGTCTCTGCTCCTACAT CCAGCTCCTCTAGGGGCAGCCTCCGTCATCCATGCCCTCCCAGGACCCTCCACTCACTGCTGTGAGTGCGCCTCACCAGAACCAGTTAAGAGACAACTAT CAATTCTTGAGACCCAAATTATAAGGGCCCTGCCCTGTACTGAAGAAAAGGGGAGCACAAGGCCTTAATGGACATTGACTTGTGAAAACGCAAACATGAA TATGGTTGGAGAGCCCTGGATTAGGAGGGTGACATGGGGAAGGCAGAGGCTGGCACCATGGTGACTGCCACATAATAAAGTGGTGATTTGGATTTTGAGC ATCTTTTTCCTGGTACACACAGAAAAACATTTTATAATGGAAGTCGGTTTCTTGGCCATCTACATAGTTTTCTGGGCAGCGCCAAGCAGGGAGGTGTCTC CAGTTGTGAGTCCTCGGACAGGCTGCTGCATGGGTGCACATACTCACGTTATTGGTGGAAGTTTTAAGTCCCAAACTGAAGGGAAGGAGGCCTAGGTGGC ACAATCAGGGAGGAATATACATCTGAGAAGTTTTGGGAAGACATCACCTGGCAAGGCTGCCTGAACCACAGTAATTTAGTCTTCCTCTATCCAGATCACT GAGAGTTGTGTGCTGGTCTTCTCTCAAACCCTGGATGTGTTACCTGCTTCTCCCTAAGTGCTCTAACCTCGCTGAACTATGAGCCTGAAGGGTGGGTCGA TGCCAGACCTTAGGTGGAGGCCAAAGACAGTACAGAATAAACAGCTTCTTCCTAAATTGACCCCA

DPH1.F14 (forward primer)
DPH1.R13 (reverse primer)
Single exon skipping

Frame 0

LRSPRSSSAVFLVPHAQAGDGGAGRIRGSGAGR PRRPWQRSGPSGPRGQSDPP*DPEEPSAAGSNPG PAFQLQL*DPQDHLEDPTSPGQEGGLANAGRPP PLCLYHCGYLGKFPWTPRPKTSGCCTSLWTSG* TLHTSWTLSASPFPQPLPLPWSAPFSLCRPCRQP PRS*KPSIV*VSHSASPCPLERSWAAHPPDCPK RWRPLCILEMAASIWSLS*LPTPMSPLTGMTHI AKSYPENTMTTSACRLLAKKP*PLPAQLSPGALF WALWAARAVLRSWSTWNLDSEPWAFPL*GCCSL RSSPASLAYFLRWMCGCRWHVHVSPLTGAQPSP SRC*HPMRRPWL*GTFPGSSPTRWTSTLAAPWGP GR*TTARTAVPTPRAGPRGGRCRRGPRVPLRPW LARTAAAGTRRWRRWLLDALPGLRVLPSGGAAS RLVVFRAGGRRFLRIGRARRLQGPGGITGDGGTG TEQAGAF*RPSWFQPRGCASSPCVCPGPGRRSP LPLATVYPLGVWFLSPGHWVQGIHPAKALVIAF APCFWGH*QSHPLSGECATGQPISRSHHPHPLWW PLHSSSCTPASGLPQVLGPVCRVKDQEMSLLLH PAPLGAASVIHALPGPSTHCCECASPEPVKRQL SILETQIIRALPCTEEKGSTRP*WTLTCENANMN MVGEPWIRRVTWGRQRLAPW*LPHNKVVIWILS IFFLVHTEKHFIMEVGFLAIYIVFWAAPSREVS PVVSPRTGCCMGAHTHVIGGSFKSQTEGKEA*VA QSGRNIHLRSFGKTSPGKAA*TTVI*SSSIQIT ESCVLVFSQTLDVLPASP*VL*PR*TMSLKGGS MPDLRWRPKTVQNKQLLPKLTP

Frame 1

CALRVLPALSF*YHMRRQVMAALVVSGAAEQGG RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIR VLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLL LFACTIVDILESSHGHLGPRLPGAVRLCGHPDR HYTPPGLSPPHLSPSHCPCPGQHHSVCVDLAGS RPGAESRVSCECPTVQAPVPWRDPGLHIPPTVQR GGGRCVSWRWPLPSGVCHDCQPQCPRLPV*PI* QSPIQRTL*PPAHAGCSPRSHSHCPLS*VLGPY SGHFGPPGQS*DPGAPGISTPSLGPFLCEAAAL* DLPQQA*PTS*GGCVGAGGMSTSLH*LGHSLPQ AAADTL*GGRGSEGHFLAAALPDGLLRWQLLGA LDGEPRPGPPSPRPGPARAGEGAGGVRASPFGRG LRGLQLQGREGGAAGSLTRSRASGSCPPEEQPR GWWFSEQEADVFSALEEPAVCRGLEESLGMVAQ ALNRLGPFDGLLGFSQGAALAALVCALGQAGDPR FPLPRFILLVSGFCPRGIGFKESILQRPLSLPS LHVFGDTDKVIPSQESVQLASQFPGAITLTHSG GHFIPAAAPQRQAYLKFLDQFAE*KIKKCLCSYI QLL*GQPPSSMPSQDPPLTAVSAPHQNQLRDNY QFLRPKL*GPCPVLKKRGAQGLNGH*LVKTQT* IWLESPGLGG*HGEGRGWHHGDCHIIKW*FGF*A SFSWYTQKNIL*WKSVSWPST*FSGQRQAGRCL QL*VLGQAAAWVHILTLLVEVLSPKLKGRRPRW HNQGGIYI*EVLGRHHLARLPEPQ*FSLPLSRSL RVVCWSSLKPWMCYLLLPKCSNLAEL*A*RVGR CQTLGGGQRQYRINSFFLN*P

Frame 2

ALSAFFQRCLFSTTCAGR*WRRWSYPGQRSRAA ETALAEVGPLGAAWPIRSPLRS*RTLSCRQQSG SCLPTTTLRSPRPSGGSNKPRPRRWPCKCRKAS SSLPVPLWISWKVPMDTSAQDFRVLYVFVDIRID TTHLLDSLRLTFPPATALALVSTIQFVSTLQAA AQELKAEYRVSVPQCKPLSPGEILGCTSPRLSK EVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYS KVLSREHYDHQRMQAARQEAIATARSAKSWGLI LGTLGRQGSPKILEHLESRLRALGLSFVRLLLS EIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPK PLLTPYEAAVALRDISWQQPYPMDFYAGSSLGP WTVNHGQDRRPHAPGRPARGKVQEGSARPPSAV ACEDCSCRDEKVAPLAP*RAPGPQGPALRRSSLE AGGFQSRRPTFSPHWKSPPSAGAWRNHWGWWHR H*TGWGLLTAFLVSAKGLR*QPLCVPWARQAIP ASPCHGLSSWCLVSVPGALGSRNPSCKGPCHCLR SMFLGTLTKSSPLRRVCNWPANFPEPSPSPTLV ATSFQQLHPSVRPTSSSWTSLQSERSRNVSAPT SSSSRGSLRHPCPPRTLHSLL*VRLTRTS*ETTI NS*DPNYKGPALY*RKGEHKALMDIDL*KRKHE YGWRALD*EGDMGKAEAGTMVTAT**SGDLDFE HLFPGTHRKTFYNGSRFLGHLHSFLGSAKQGGVS SCESSDRLLHGCTYSRYWWKF*VPN*REGGLGG TIREEYTSEKFWEDITWQGCLNHSNLVFLYPDH *ELCAGLLSNPGCVTCFSLSALTSLNYEPEGWVD ARP*VEAKDSTE*TASS*IDP

Sequence DPH1.bAug05

CTGCGCTCTCCGCGTTCTTCCAGCGCTGTCTTTTTAGTACCACATGCGCAGGCAGGTGATGGCGGCGCTGGTCGTATCCGGGGCAGCGGAGCAGGGCGGC CGAGACGGCCCTGGCAGAGGTCGGGCCCCTCGGGGCCGCGTGGCCAATCAGATCCCCCCTGAGATCCTGAAGAACCCTCAGCTGCAGGCAGCAATCCGGG TCCTGCCTTCCAACTACAACTTTGAGATCCCCAAGACCATCTGGAGGATCCAACAAGCCCAGGCCAAGAAGGTGGCCTTGCAAATGCCGGAAGGCCTCCT CCTCTTTGCCTGTACCATTGTGGATATCTTGGAAAGGTTCACGGAGGCCGAAGTGATGGTGATGGGTGACGTGACCTACGGGGCTTGCTGTGTGGATGAC TTCACAGCGAGGGCCCTGGGAGCTGACTTCTTGGTGCACTACGGCCACAGTTGCCTGATTCCCATGGACACCTCGGCCCAAGACTTCCGGGTGCTGTACG TCTTTGTGGACATCCGGATAGACACTACACACCTCCTGGACTCTCTCCGCCTCACCTTTCCCCCAGCCACTGCCCTTGCCCTGGCAGCCGCCCAGGAGCT GAAAGCCGAGTATCGTGTGAGTGTCCCACAGTGCAAGCCCCTGTCCCCTGGAGAGATCCTGGGCTGCACATCCCCCCGACTGTCCAAAGAGGTGGAGGCC GTTGTGTATCTTGGAGATGGCCGCTTCCATCTGGAGTCTGTCATGATTGCCAACCCCAATGTCCCCGCTTACCGGTATGACCCATATAGCAAAGTCCTAT CCAGAGAACACTATGACCACCAGCGCATGCAGGCTGCTCGCCAAGAAGCCATAGCCACTGCCCGCTCAGCTAAGTCCTGGGGCCTTATTCTGGGCACTTT GGGCCGCCAGGGCAGTCCTAAGATCCTGGAGCACCTGGAATCTCGACTCCGAGCCTTGGGCCTTTCCTTTGTGAGGCTGCTGCTCTCTGAGATCTTCCCC AGCAAGCTTAGCCTACTTCCTGAGGTGGATGTGTGGGTGCAGGTGGCATGTCCACGTCTCTCCATTGACTGGGGCACAGCCTTCCCCAAGCCGCTGCTGA CACCCTATGAGGCGGCCGTGGCTCTGAGGGACATTTCCTGGCAGCAGCCCTACCCGATGGACTTCTACGCTGGCAGCTCCTTGGGGCCCTGGACGGTGAA CCACGGCCAGGACCGCCGTCCCCACGCCCCGGGCCGGCCCGCGCGGGGGAAGGTGCAGGAGGGGTCCGCGCGTCCCCCTTCGGCCGTGGCTTGCGAGGAC TGCAGCTGCAGGGACGAGAAGGTGGCGCCGCTGGCTCCTTGACGCGCTCCCGGGCCTCAGGAGAGTGTGCAACTGGCCAGCCAATTTCCCGGAGCCATCA CCCTCACCCACTCTGGTGGCCACTTCATTCCAGCAGCTGCACCCCAGCGTCAGGCCTACCTCAAGTTCTTGGACCAGTTTGCAGAGTGAAAGATCAAGAA ATGTCTCTGCTCCTACATCCAGCTCCTCTAGGGGCAGCCTCCGTCATCCATGCCCTCCCAGGACCCTCCACTCACTGCTGTGAGTGCGCCTCACCAGAAC CAGTTAAGAGACAACTATCAATTCTTGAGACCCAAATTATAAGGGCCCTGCCCTGTACTGAAGAAAAGGGGAGCACAAGGCCTTAATGGACATTGACTTG TGAAAACGCAAACATGAATATGGTTGGAGAGCCCTGGATTAGGAGGGTGACATGGGGAAGGCAGAGGCTGGCACCATGGTGACTGCCACATAATAAAGTG GTGATTTGGATTTTGAGCATCTTTTTCCTGGTACACACAGAAAAACATTTTATAATGGAAGTCGGTTTCTTGGCCATCTACATAGTTTTCTGGGCAGCGC CAAGCAGGGAGGTGTCTCCAGTTGTGAGTCCTCGGACAGGCTGCTGCATGGGTGCACATACTCACGTTATTGGTGGAAGTTTTAAGTCCCAAACTGAAGG GAAGGAGGCCTAGGTGGCACAATCAGGGAGGAATATACATCTGAGAAGTTTTGGGAAGACATCACCTGGCAAGGCTGCCTGAACCACAGTAATTTAGTCT TCCTCTATCCAGATCACTGAGAGTTGTGTGCTGGTCTTCTCTCAAACCCTGGATGTGTTACCTGCTTCTCCCTAAGTGCTCTAACCTCGCTGAACTATGA GCCTGAAGGGTGGGTCGATGCCAGACCTTAGGTGGAGGCCAAAGACAGTACAGAATAAACAGCTTCTTCCTAAATTGACCCCA

DPH1.F14 (forward primer)
DPH1.R13 (reverse primer)
Single exon skipping

Frame 0

LRSPRSSSAVFLVPHAQAGDGGAGRIRGSGAGR PRRPWQRSGPSGPRGQSDPP*DPEEPSAAGSNPG PAFQLQL*DPQDHLEDPTSPGQEGGLANAGRPP PLCLYHCGYLGKVHGGRSDGDG*RDLRGLLCG* LHSEGPGS*LLGALRPQLPDSHGHLGPRLPGAVR LCGHPDRHYTPPGLSPPHLSPSHCPCPGSRPGA ESRVSCECPTVQAPVPWRDPGLHIPPTVQRGGG RCVSWRWPLPSGVCHDCQPQCPRLPV*PI*QSPI QRTL*PPAHAGCSPRSHSHCPLS*VLGPYSGHF GPPGQS*DPGAPGISTPSLGPFLCEAAAL*DLP QQA*PTS*GGCVGAGGMSTSLH*LGHSLPQAAAD TL*GGRGSEGHFLAAALPDGLLRWQLLGALDGE PRPGPPSPRPGPARAGEGAGGVRASPFGRGLRG LQLQGREGGAAGSLTRSRASGECATGQPISRSHH PHPLWWPLHSSSCTPASGLPQVLGPVCRVKDQE MSLLLHPAPLGAASVIHALPGPSTHCCECASPE PVKRQLSILETQIIRALPCTEEKGSTRP*WTLTC ENANMNMVGEPWIRRVTWGRQRLAPW*LPHNKV VIWILSIFFLVHTEKHFIMEVGFLAIYIVFWAA PSREVSPVVSPRTGCCMGAHTHVIGGSFKSQTEG KEA*VAQSGRNIHLRSFGKTSPGKAA*TTVI*S SSIQITESCVLVFSQTLDVLPASP*VL*PR*TM SLKGGSMPDLRWRPKTVQNKQLLPKLTP

Frame 1

CALRVLPALSF*YHMRRQVMAALVVSGAAEQGG RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIR VLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLL LFACTIVDILERFTEAEVMVMGDVTYGACCVDD FTARALGADFLVHYGHSCLIPMDTSAQDFRVLY VFVDIRIDTTHLLDSLRLTFPPATALALAAAQEL KAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEA VVYLGDGRFHLESVMIANPNVPAYRYDPYSKVL SREHYDHQRMQAARQEAIATARSAKSWGLILGTL GRQGSPKILEHLESRLRALGLSFVRLLLSEIFP SKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLL TPYEAAVALRDISWQQPYPMDFYAGSSLGPWTVN HGQDRRPHAPGRPARGKVQEGSARPPSAVACED CSCRDEKVAPLAP*RAPGPQESVQLASQFPGAI TLTHSGGHFIPAAAPQRQAYLKFLDQFAE*KIKK CLCSYIQLL*GQPPSSMPSQDPPLTAVSAPHQN QLRDNYQFLRPKL*GPCPVLKKRGAQGLNGH*L VKTQT*IWLESPGLGG*HGEGRGWHHGDCHIIKW *FGF*ASFSWYTQKNIL*WKSVSWPST*FSGQR QAGRCLQL*VLGQAAAWVHILTLLVEVLSPKLK GRRPRWHNQGGIYI*EVLGRHHLARLPEPQ*FSL PLSRSLRVVCWSSLKPWMCYLLLPKCSNLAEL* A*RVGRCQTLGGGQRQYRINSFFLN*P

Frame 2

ALSAFFQRCLFSTTCAGR*WRRWSYPGQRSRAA ETALAEVGPLGAAWPIRSPLRS*RTLSCRQQSG SCLPTTTLRSPRPSGGSNKPRPRRWPCKCRKAS SSLPVPLWISWKGSRRPK*W*WVT*PTGLAVWMT SQRGPWELTSWCTTATVA*FPWTPRPKTSGCCT SLWTSG*TLHTSWTLSASPFPQPLPLPWQPPRS *KPSIV*VSHSASPCPLERSWAAHPPDCPKRWRP LCILEMAASIWSLS*LPTPMSPLTGMTHIAKSY PENTMTTSACRLLAKKP*PLPAQLSPGALFWAL WAARAVLRSWSTWNLDSEPWAFPL*GCCSLRSSP ASLAYFLRWMCGCRWHVHVSPLTGAQPSPSRC* HPMRRPWL*GTFPGSSPTRWTSTLAAPWGPGR* TTARTAVPTPRAGPRGGRCRRGPRVPLRPWLART AAAGTRRWRRWLLDALPGLRRVCNWPANFPEPS PSPTLVATSFQQLHPSVRPTSSSWTSLQSERSR NVSAPTSSSSRGSLRHPCPPRTLHSLL*VRLTRT S*ETTINS*DPNYKGPALY*RKGEHKALMDIDL *KRKHEYGWRALD*EGDMGKAEAGTMVTAT**S GDLDFEHLFPGTHRKTFYNGSRFLGHLHSFLGSA KQGGVSSCESSDRLLHGCTYSRYWWKF*VPN*R EGGLGGTIREEYTSEKFWEDITWQGCLNHSNLV FLYPDH*ELCAGLLSNPGCVTCFSLSALTSLNYE PEGWVDARP*VEAKDSTE*TASS*IDP

Sequence DPH1.aAug05

CTGCGCTCTCCGCGTTCTTCCAGCGCTGTCTTTTTAGTACCACATGCGCAGGCAGGTGATGGCGGCGCTGGTCGTATCCGGGGCAGCGGAGCAGGGCGGC CGAGACGGCCCTGGCAGAGGTCGGGCCCCTCGGGGCCGCGTGGCCAATCAGATCCCCCCTGAGATCCTGAAGAACCCTCAGCTGCAGGCAGCAATCCGGG TCCTGCCTTCCAACTACAACTTTGAGATCCCCAAGACCATCTGGAGGATCCAACAAGCCCAGGCCAAGAAGGTGGCCTTGCAAATGCCGGAAGGCCTCCT CCTCTTTGCCTGTACCATTGTGGATATCTTGGAAAGGTTCACGGAGGCCGAAGTGATGGTGATGGGTGACGTGACCTACGGGGCTTGCTGTGTGGATGAC TTCACAGCGAGGGCCCTGGGAGCTGACTTCTTGGTGCACTACGGCCACAGTTGCCTGATTCCCATGGACACCTCGGCCCAAGACTTCCGGGTGCTGTACG TCTTTGTGGACATCCGGATAGACACTACACACCTCCTGGACTCTCTCCGCCTCACCTTTCCCCCAGCCACTGCCCTTGCCCTGGTCAGCACCATTCAGTT TGTGTCGACCTTGCAGGCAGCCGCCCAGGAGCTGAAAGCCGAGTATCGTGTGAGTGTCCCACAGTGCAAGCCCCTGTCCCCTGGAGAGATCCTGGGCTGC ACATCCCCCCGACTGTCCAAAGAGGTGGAGGCCGTTGTGTATCTTGGAGATGGCCGCTTCCATCTGGAGTCTGTCATGATTGCCAACCCCAATGTCCCCG CTTACCGGTATGACCCATATAGCAAAGTCCTATCCAGAGAACACTATGACCACCAGCGCATGCAGGCTGCTCGCCAAGAAGCCATAGCCACTGCCCGCTC AGCTAAGTCCTGGGGCCTTATTCTGGGCACTTTGGGCCGCCAGGGCAGTCCTAAGATCCTGGAGCACCTGGAATCTCGACTCCGAGCCTTGGGCCTTTCC TTTGTGAGGCTGCTGCTCTCTGAGATCTTCCCCAGCAAGCTTAGCCTACTTCCTGAGGTGGATGTGTGGGTGCAGGTGGCATGTCCACGTCTCTCCATTG ACTGGGGCACAGCCTTCCCCAAGCCGCTGCTGACACCCTATGAGGCGGCCGTGGCTCTGAGGGACATTTCCTGGCAGCAGCCCTACCCGATGGACTTCTA CGCTGGCAGCTCCTTGGGGCCCTGGACGGTGAACCACGGCCAGGACCGCCGTCCCCACGCCCCGGGCCGGCCCGCGCGGGGGAAGGTGCAGGAGGGGTCC GCGCGTCCCCCTTCGGCCGTGGCTTGCGAGGACTGCAGCTGCAGGGACGAGAAGGTGGCGCCGCTGGCTCCTTGACGCGCTCCCGGGCCTCAGGGTCCTG CCCTCCGGAGGAGCAGCCTCGAGGCTGGTGGTTTTCAGAGCAGGAGGCCGACGTTTTCTCCGCATTGGAAGAGCCCGCCGTCTGCAGGGGCCTGGAGGAA TCACTGGGGATGGTGGCACAGGCACTGAACAGGCTGGGGCCTTTTGACGGCCTTCTTGGTTTCAGCCAAGGGGCTGCGCTAGCAGCCCTTGTGTGTGCCC TGGGCCAGGCAGGCGATCCCCGCTTCCCCTTGCCACGGTTTATCCTCTTGGTGTCTGGTTTCTGTCCCCGGGGCATTGGGTTCAAGGAATCCATCCTGCA AAGGCCCTTGTCATTGCCTTCGCTCCATGTTTTTGGGGACACTGACAAAGTCATCCCCTCTCAGGAGAGTGTGCAACTGGCCAGCCAATTTCCCGGAGCC ATCACCCTCACCCACTCTGGTGGCCACTTCATTCCAGCAGCTGCACCCCAGCGTCAGGCCTACCTCAAGTTCTTGGACCAGTTTGCAGAGTGAAAGATCA AGAAATGTCTCTGCTCCTACATCCAGCTCCTCTAGGGGCAGCCTCCGTCATCCATGCCCTCCCAGGACCCTCCACTCACTGCTGTGAGTGCGCCTCACCA GAACCAGTTAAGAGACAACTATCAATTCTTGAGACCCAAATTATAAGGGCCCTGCCCTGTACTGAAGAAAAGGGGAGCACAAGGCCTTAATGGACATTGA CTTGTGAAAACGCAAACATGAATATGGTTGGAGAGCCCTGGATTAGGAGGGTGACATGGGGAAGGCAGAGGCTGGCACCATGGTGACTGCCACATAATAA AGTGGTGATTTGGATTTTGAGCATCTTTTTCCTGGTACACACAGAAAAACATTTTATAATGGAAGTCGGTTTCTTGGCCATCTACATAGTTTTCTGGGCA GCGCCAAGCAGGGAGGTGTCTCCAGTTGTGAGTCCTCGGACAGGCTGCTGCATGGGTGCACATACTCACGTTATTGGTGGAAGTTTTAAGTCCCAAACTG AAGGGAAGGAGGCCTAGGTGGCACAATCAGGGAGGAATATACATCTGAGAAGTTTTGGGAAGACATCACCTGGCAAGGCTGCCTGAACCACAGTAATTTA GTCTTCCTCTATCCAGATCACTGAGAGTTGTGTGCTGGTCTTCTCTCAAACCCTGGATGTGTTACCTGCTTCTCCCTAAGTGCTCTAACCTCGCTGAACT ATGAGCCTGAAGGGTGGGTCGATGCCAGACCTTAGGTGGAGGCCAAAGACAGTACAGAATAAACAGCTTCTTCCTAAATTGACCCCA

DPH1.F14 (forward primer)
DPH1.R13 (reverse primer)
Single exon skipping

Frame 0

LRSPRSSSAVFLVPHAQAGDGGAGRIRGSGAGR PRRPWQRSGPSGPRGQSDPP*DPEEPSAAGSNPG PAFQLQL*DPQDHLEDPTSPGQEGGLANAGRPP PLCLYHCGYLGKVHGGRSDGDG*RDLRGLLCG* LHSEGPGS*LLGALRPQLPDSHGHLGPRLPGAVR LCGHPDRHYTPPGLSPPHLSPSHCPCPGQHHSV CVDLAGSRPGAESRVSCECPTVQAPVPWRDPGL HIPPTVQRGGGRCVSWRWPLPSGVCHDCQPQCPR LPV*PI*QSPIQRTL*PPAHAGCSPRSHSHCPL S*VLGPYSGHFGPPGQS*DPGAPGISTPSLGPF LCEAAAL*DLPQQA*PTS*GGCVGAGGMSTSLH* LGHSLPQAAADTL*GGRGSEGHFLAAALPDGLL RWQLLGALDGEPRPGPPSPRPGPARAGEGAGGV RASPFGRGLRGLQLQGREGGAAGSLTRSRASGSC PPEEQPRGWWFSEQEADVFSALEEPAVCRGLEE SLGMVAQALNRLGPFDGLLGFSQGAALAALVCA LGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQ RPLSLPSLHVFGDTDKVIPSQESVQLASQFPGA ITLTHSGGHFIPAAAPQRQAYLKFLDQFAE*KI KKCLCSYIQLL*GQPPSSMPSQDPPLTAVSAPHQ NQLRDNYQFLRPKL*GPCPVLKKRGAQGLNGH* LVKTQT*IWLESPGLGG*HGEGRGWHHGDCHII KW*FGF*ASFSWYTQKNIL*WKSVSWPST*FSGQ RQAGRCLQL*VLGQAAAWVHILTLLVEVLSPKL KGRRPRWHNQGGIYI*EVLGRHHLARLPEPQ*F SLPLSRSLRVVCWSSLKPWMCYLLLPKCSNLAEL *A*RVGRCQTLGGGQRQYRINSFFLN*P

Frame 1

CALRVLPALSF*YHMRRQVMAALVVSGAAEQGG RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIR VLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLL LFACTIVDILERFTEAEVMVMGDVTYGACCVDD FTARALGADFLVHYGHSCLIPMDTSAQDFRVLY VFVDIRIDTTHLLDSLRLTFPPATALALVSTIQF VSTLQAAAQELKAEYRVSVPQCKPLSPGEILGC TSPRLSKEVEAVVYLGDGRFHLESVMIANPNVP AYRYDPYSKVLSREHYDHQRMQAARQEAIATARS AKSWGLILGTLGRQGSPKILEHLESRLRALGLS FVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSI DWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFY AGSSLGPWTVNHGQDRRPHAPGRPARGKVQEGS ARPPSAVACEDCSCRDEKVAPLAP*RAPGPQGP ALRRSSLEAGGFQSRRPTFSPHWKSPPSAGAWRN HWGWWHRH*TGWGLLTAFLVSAKGLR*QPLCVP WARQAIPASPCHGLSSWCLVSVPGALGSRNPSC KGPCHCLRSMFLGTLTKSSPLRRVCNWPANFPEP SPSPTLVATSFQQLHPSVRPTSSSWTSLQSERS RNVSAPTSSSSRGSLRHPCPPRTLHSLL*VRLT RTS*ETTINS*DPNYKGPALY*RKGEHKALMDID L*KRKHEYGWRALD*EGDMGKAEAGTMVTAT** SGDLDFEHLFPGTHRKTFYNGSRFLGHLHSFLG SAKQGGVSSCESSDRLLHGCTYSRYWWKF*VPN* REGGLGGTIREEYTSEKFWEDITWQGCLNHSNL VFLYPDH*ELCAGLLSNPGCVTCFSLSALTSLN YEPEGWVDARP*VEAKDSTE*TASS*IDP

Frame 2

ALSAFFQRCLFSTTCAGR*WRRWSYPGQRSRAA ETALAEVGPLGAAWPIRSPLRS*RTLSCRQQSG SCLPTTTLRSPRPSGGSNKPRPRRWPCKCRKAS SSLPVPLWISWKGSRRPK*W*WVT*PTGLAVWMT SQRGPWELTSWCTTATVA*FPWTPRPKTSGCCT SLWTSG*TLHTSWTLSASPFPQPLPLPWSAPFS LCRPCRQPPRS*KPSIV*VSHSASPCPLERSWAA HPPDCPKRWRPLCILEMAASIWSLS*LPTPMSP LTGMTHIAKSYPENTMTTSACRLLAKKP*PLPA QLSPGALFWALWAARAVLRSWSTWNLDSEPWAFP L*GCCSLRSSPASLAYFLRWMCGCRWHVHVSPL TGAQPSPSRC*HPMRRPWL*GTFPGSSPTRWTS TLAAPWGPGR*TTARTAVPTPRAGPRGGRCRRGP RVPLRPWLARTAAAGTRRWRRWLLDALPGLRVL PSGGAASRLVVFRAGGRRFLRIGRARRLQGPGG ITGDGGTGTEQAGAF*RPSWFQPRGCASSPCVCP GPGRRSPLPLATVYPLGVWFLSPGHWVQGIHPA KALVIAFAPCFWGH*QSHPLSGECATGQPISRS HHPHPLWWPLHSSSCTPASGLPQVLGPVCRVKDQ EMSLLLHPAPLGAASVIHALPGPSTHCCECASP EPVKRQLSILETQIIRALPCTEEKGSTRP*WTL TCENANMNMVGEPWIRRVTWGRQRLAPW*LPHNK VVIWILSIFFLVHTEKHFIMEVGFLAIYIVFWA APSREVSPVVSPRTGCCMGAHTHVIGGSFKSQT EGKEA*VAQSGRNIHLRSFGKTSPGKAA*TTVI* SSSIQITESCVLVFSQTLDVLPASP*VL*PR*T MSLKGGSMPDLRWRPKTVQNKQLLPKLTP

Sequence DPH1.dAug05

CTGCGCTCTCCGCGTTCTTCCAGCGCTGTCTTTTTAGTACCACATGCGCAGGCAGGTGATGGCGGCGCTGGTCGTATCCGGGGCAGCGGAGCAGGGCGGC CGAGACGGCCCTGGCAGAGGTCGGGCCCCTCGGGGCCGCGTGGCCAATCAGATCCCCCCTGAGATCCTGAAGAACCCTCAGCTGCAGGCAGCAATCCGGG TCCTGCCTTCCAACTACAACTTTGAGATCCCCAAGACCATCTGGAGGATCCAACAAGCCCAGGCCAAGAAGGTGGCCTTGCAAATGCCGGAAGGCCTCCT CCTCTTTGCCTGTACCATTGTGGATATCTTGGAAAGGTTCACGGAGGCCGAAGTGATGGTGATGGGTGACGTGACCTACGGGGCTTGCTGTGTGGATGAC TTCACAGCGAGGGCCCTGGGAGCTGACTTCTTGGTGCACTACGGCCACAGTTGCCTGATTCCCATGGACACCTCGGCCCAAGACTTCCGGGTGCTGTACG TCTTTGTGGACATCCGGATAGACACTACACACCTCCTGGACTCTCTCCGCCTCACCTTTCCCCCAGCCACTGCCCTTGCCCTGGTCAGCACCATTCAGTT TGTGTCGACCTTGCAGGCAGCCGCCCAGGAGCTGAAAGCCGAGTATCGTGTGAGTGTCCCACAGTGCAAGCCCCTGTCCCCTGGAGAGATCCTGGGCTGC ACATCCCCCCGACTGTCCAAAGAGGTGGAGGCCGTTGTGTATCTTGGAGATGGCCGCTTCCATCTGGAGTCTGTCATGATTGCCAACCCCAATGTCCCCG CTTACCGGTATGACCCATATAGCAAAGTCCTATCCAGAGAACACTATGACCACCAGCGCATGCAGGCTGCTCGCCAAGAAGCCATAGCCACTGCCCGCTC AGCTAAGTCCTGGGGCCTTATTCTGGGCACTTTGGGCCGCCAGGGCAGTCCTAAGATCCTGGAGCACCTGGAATCTCGACTCCGAGCCTTGGGCCTTTCC TTTGTGAGGCTGCTGCTCTCTGAGATCTTCCCCAGCAAGCTTAGCCTACTTCCTGAGGTGGATGTGCGGCCGTGGCTCTGAGGGACATTTCCTGGCAGCA GCCCTACCCGATGGACTTCTACGCTGGCAGCTCCTTGGGGCCCTGGACGGTGAACCACGGCCAGGACCGCCGTCCCCACGCCCCGGGCCGGCCCGCGCGG GGGAAGGTGCAGGAGGGGTCCGCGCGTCCCCCTTCGGCCGTGGCTTGCGAGGACTGCAGCTGCAGGGACGAGAAGGTGGCGCCGCTGGCTCCTTGACGCG CTCCCGGGCCTCAGGAGAGTGTGCAACTGGCCAGCCAATTTCCCGGAGCCATCACCCTCACCCACTCTGGTGGCCACTTCATTCCAGCAGCTGCACCCCA GCGTCAGGCCTACCTCAAGTTCTTGGACCAGTTTGCAGAGTGAAAGATCAAGAAATGTCTCTGCTCCTACATCCAGCTCCTCTAGGGGCAGCCTCCGTCA TCCATGCCCTCCCAGGACCCTCCACTCACTGCTGTGAGTGCGCCTCACCAGAACCAGTTAAGAGACAACTATCAATTCTTGAGACCCAAATTATAAGGGC CCTGCCCTGTACTGAAGAAAAGGGGAGCACAAGGCCTTAATGGACATTGACTTGTGAAAACGCAAACATGAATATGGTTGGAGAGCCCTGGATTAGGAGG GTGACATGGGGAAGGCAGAGGCTGGCACCATGGTGACTGCCACATAATAAAGTGGTGATTTGGATTTTGAGCATCTTTTTCCTGGTACACACAGAAAAAC ATTTTATAATGGAAGTCGGTTTCTTGGCCATCTACATAGTTTTCTGGGCAGCGCCAAGCAGGGAGGTGTCTCCAGTTGTGAGTCCTCGGACAGGCTGCTG CATGGGTGCACATACTCACGTTATTGGTGGAAGTTTTAAGTCCCAAACTGAAGGGAAGGAGGCCTAGGTGGCACAATCAGGGAGGAATATACATCTGAGA AGTTTTGGGAAGACATCACCTGGCAAGGCTGCCTGAACCACAGTAATTTAGTCTTCCTCTATCCAGATCACTGAGAGTTGTGTGCTGGTCTTCTCTCAAA CCCTGGATGTGTTACCTGCTTCTCCCTAAGTGCTCTAACCTCGCTGAACTATGAGCCTGAAGGGTGGGTCGATGCCAGACCTTAGGTGGAGGCCAAAGAC AGTACAGAATAAACAGCTTCTTCCTAAATTGACCCCA

DPH1.F14 (forward primer)
DPH1.R13 (reverse primer)
Single exon skipping

Frame 0

LRSPRSSSAVFLVPHAQAGDGGAGRIRGSGAGR PRRPWQRSGPSGPRGQSDPP*DPEEPSAAGSNPG PAFQLQL*DPQDHLEDPTSPGQEGGLANAGRPP PLCLYHCGYLGKVHGGRSDGDG*RDLRGLLCG* LHSEGPGS*LLGALRPQLPDSHGHLGPRLPGAVR LCGHPDRHYTPPGLSPPHLSPSHCPCPGQHHSV CVDLAGSRPGAESRVSCECPTVQAPVPWRDPGL HIPPTVQRGGGRCVSWRWPLPSGVCHDCQPQCPR LPV*PI*QSPIQRTL*PPAHAGCSPRSHSHCPL S*VLGPYSGHFGPPGQS*DPGAPGISTPSLGPF LCEAAAL*DLPQQA*PTS*GGCAAVALRDISWQQ PYPMDFYAGSSLGPWTVNHGQDRRPHAPGRPAR GKVQEGSARPPSAVACEDCSCRDEKVAPLAP*R APGPQESVQLASQFPGAITLTHSGGHFIPAAAPQ RQAYLKFLDQFAE*KIKKCLCSYIQLL*GQPPS SMPSQDPPLTAVSAPHQNQLRDNYQFLRPKL*G PCPVLKKRGAQGLNGH*LVKTQT*IWLESPGLGG *HGEGRGWHHGDCHIIKW*FGF*ASFSWYTQKN IL*WKSVSWPST*FSGQRQAGRCLQL*VLGQAA AWVHILTLLVEVLSPKLKGRRPRWHNQGGIYI*E VLGRHHLARLPEPQ*FSLPLSRSLRVVCWSSLK PWMCYLLLPKCSNLAEL*A*RVGRCQTLGGGQR QYRINSFFLN*P

Frame 1

CALRVLPALSF*YHMRRQVMAALVVSGAAEQGG RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIR VLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLL LFACTIVDILERFTEAEVMVMGDVTYGACCVDD FTARALGADFLVHYGHSCLIPMDTSAQDFRVLY VFVDIRIDTTHLLDSLRLTFPPATALALVSTIQF VSTLQAAAQELKAEYRVSVPQCKPLSPGEILGC TSPRLSKEVEAVVYLGDGRFHLESVMIANPNVP AYRYDPYSKVLSREHYDHQRMQAARQEAIATARS AKSWGLILGTLGRQGSPKILEHLESRLRALGLS FVRLLLSEIFPSKLSLLPEVDVRPWL*GTFPGS SPTRWTSTLAAPWGPGR*TTARTAVPTPRAGPRG GRCRRGPRVPLRPWLARTAAAGTRRWRRWLLDA LPGLRRVCNWPANFPEPSPSPTLVATSFQQLHP SVRPTSSSWTSLQSERSRNVSAPTSSSSRGSLRH PCPPRTLHSLL*VRLTRTS*ETTINS*DPNYKG PALY*RKGEHKALMDIDL*KRKHEYGWRALD*E GDMGKAEAGTMVTAT**SGDLDFEHLFPGTHRKT FYNGSRFLGHLHSFLGSAKQGGVSSCESSDRLL HGCTYSRYWWKF*VPN*REGGLGGTIREEYTSE KFWEDITWQGCLNHSNLVFLYPDH*ELCAGLLSN PGCVTCFSLSALTSLNYEPEGWVDARP*VEAKD STE*TASS*IDP

Frame 2

ALSAFFQRCLFSTTCAGR*WRRWSYPGQRSRAA ETALAEVGPLGAAWPIRSPLRS*RTLSCRQQSG SCLPTTTLRSPRPSGGSNKPRPRRWPCKCRKAS SSLPVPLWISWKGSRRPK*W*WVT*PTGLAVWMT SQRGPWELTSWCTTATVA*FPWTPRPKTSGCCT SLWTSG*TLHTSWTLSASPFPQPLPLPWSAPFS LCRPCRQPPRS*KPSIV*VSHSASPCPLERSWAA HPPDCPKRWRPLCILEMAASIWSLS*LPTPMSP LTGMTHIAKSYPENTMTTSACRLLAKKP*PLPA QLSPGALFWALWAARAVLRSWSTWNLDSEPWAFP L*GCCSLRSSPASLAYFLRWMCGRGSEGHFLAA ALPDGLLRWQLLGALDGEPRPGPPSPRPGPARA GEGAGGVRASPFGRGLRGLQLQGREGGAAGSLTR SRASGECATGQPISRSHHPHPLWWPLHSSSCTP ASGLPQVLGPVCRVKDQEMSLLLHPAPLGAASV IHALPGPSTHCCECASPEPVKRQLSILETQIIRA LPCTEEKGSTRP*WTLTCENANMNMVGEPWIRR VTWGRQRLAPW*LPHNKVVIWILSIFFLVHTEK HFIMEVGFLAIYIVFWAAPSREVSPVVSPRTGCC MGAHTHVIGGSFKSQTEGKEA*VAQSGRNIHLR SFGKTSPGKAA*TTVI*SSSIQITESCVLVFSQ TLDVLPASP*VL*PR*TMSLKGGSMPDLRWRPKT VQNKQLLPKLTP

Sequence DPH1.jAug05

CTGCGCTCTCCGCGTTCTTCCAGCGCTGTCTTTTTAGTACCACATGCGCAGGCAGGTGATGGCGGCGCTGGTCGTATCCGGGGCAGCGGAGCAGGGCGGC CGAGACGGCCCTGGCAGAGGTCGGGCCCCTCGGGGCCGCGTGGCCAATCAGATCCCCCCTGAGATCCTGAAGAACCCTCAGCTGCAGGCAGCAATCCGGG TCCTGCCTTCCAACTACAACTTTGAGATCCCCAAGACCATCTGGAGGATCCAACAAGCCCAGGCCAAGAAGGTGGCCTTGCAAATGCCGGAAGGCCTCCT CCTCTTTGCCTGTACCATTGTGGATATCTTGGAAAGGTTCACGGAGGCCGAAGTGATGGTGATGGGTGACGTGACCTACGGGGCTTGCTGTGTGGATGAC TTCACAGCGAGGGCCCTGGGAGCTGACTTCTTGGTGCACTACGGCCACAGTTGCCTGATTCCCATGGACACCTCGGCCCAAGACTTCCGGGTGCTGTACG TCTTTGTGGACATCCGGATAGACACTACACACCTCCTGGACTCTCTCCGCCTCACCTTTCCCCCAGCCACTGCCCTTGCCCTGGTCAGCACCATTCAGTT TGTGTCGACCTTGCAGGCAGCCGCCCAGGAGCTGAAAGCCGAGTATCGTGTGAGTGTCCCACAGTGCAAGCCCCTGTCCCCTGGAGAGATCCTGGGCTGC ACATCCCCCCGACTGTCCAAAGAGGTGGAGGCCGTTGTGTAAGTTAAAAATGGGGGCCAAGTAAGTCCTAGAGACATGCGTGTACCCTGGGAGGGAGCCT GAGGTTCATCATCCAGGAAAGAAACCAAATCTAATGCTCCTTACCTGTGAGCCCGAGGTCACACTGCAAGGTAGGGACCAAACAGGGAGCAGACCTCAGG TTTACTGTCGCTTTCTCCACTGCCCAGTCCATCATCCAGAAGGCTGTGCAGGGTGGGGGCAGGAATCAGAGGGCCTGATGGGGGTTGAGGGTGGGCTGGA AATGGTGGGAATATAATTGGAGAAGATGGATGGGCACGCCCAGGCTGCAGCCCCATTAATTTACCATCCGGACAGCTAACAAGCAGAAGCAGCGTGTCTC CTGCCGCCTAATTATTTTAGGTAATGGAAATGCTTAATGTTGTGTGAATGCAGCCAGCCTGAGAGCCGACGGCTCCCCCGACTGGGACTAGGGAAGGGAG TCCCGTTCCGTACTAATGGCAGGGAGGGAGGGTCGCTCCCTGACTCAGTCCCACCTCTGGGGCTTTGGAGGCTGTTTCCACAGGCCTGACACCCCTGTCC CTAGACAGGCCCACATCAGGGCCTTCCCCAGCCCAGATCTGGCAGCCCTGCTCCCCGAGCAGCACTGAGTGGCATTCCCCCTGTGCCCACGTCACTCAGT CTCTACCCTTGGGGTCTTCAAAGTGTATGTTGGAGGGAGGGACACCCTGAGTGTTAGCCATTCATCAGAATGAAGTGTGGTCTCCAAGAGGGAGAGAAGG AGCTGCCACAGGCAGGTTATCTTCCACGCTCTGTAATCTTCATGGGCTGGGAAGCTACTGTCAGGGACAGCATGTCTGGGGGCACACTTGGTACAGCCTG GGTTGAGCCTCAGACACACTGCTTCCTAGCTGTTTAATACTAGGCGAGTTTCTTAACATCCCTGAGCCTCAGTTGTTACCTTCTGTAAAACAGGTATACT ATACGTATCTGGGAGGATTAGGAGATAGGACTGCGTGAACTAATTCACAGCAGGTACTTAGTCTATGCCTGGTACACAGAAGGCACAAGTCCAATAAACA GTAGCTGTTGGCCGGGCACAGTGGCTCACGCCTGTAATCTCAACACTTTGGGAGGCCAAGGCAGGAGAATTGCATATGTCCAGGAGTTTGAGACCAGCTT GGGGAATATAATGAAACCCTGTTCTCTCC

DPH1.F14 (forward primer)
DPH1.R13 (reverse primer)
Single exon skipping

Frame 0

LRSPRSSSAVFLVPHAQAGDGGAGRIRGSGAGR PRRPWQRSGPSGPRGQSDPP*DPEEPSAAGSNPG PAFQLQL*DPQDHLEDPTSPGQEGGLANAGRPP PLCLYHCGYLGKVHGGRSDGDG*RDLRGLLCG* LHSEGPGS*LLGALRPQLPDSHGHLGPRLPGAVR LCGHPDRHYTPPGLSPPHLSPSHCPCPGQHHSV CVDLAGSRPGAESRVSCECPTVQAPVPWRDPGL HIPPTVQRGGGRCVS*KWGPSKS*RHACTLGGSL RFIIQERNQI*CSLPVSPRSHCKVGTKQGADLR FTVAFSTAQSIIQKAVQGGGRNQRA*WGLRVGW KWWEYNWRRWMGTPRLQPH*FTIRTANKQKQRVS CRLIILGNGNA*CCVNAASLRADGSPDWD*GRE SRSVLMAGREGRSLTQSHLWGFGGCFHRPDTPV PRQAHIRAFPSPDLAALLPEQH*VAFPLCPRHSV STLGVFKVYVGGRDTLSVSHSSE*SVVSKRERR SCHRQVIFHAL*SSWAGKLLSGTACLGAHLVQP GLSLRHTAS*LFNTRRVS*HP*ASVVTFCKTGIL YVSGRIRR*DCVN*FTAGT*SMPGTQKAQVQ*T VAVGRAQWLTPVISTLWEAKAGELHMSRSLRPA WGI**NPVLS

Frame 1

CALRVLPALSF*YHMRRQVMAALVVSGAAEQGG RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIR VLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLL LFACTIVDILERFTEAEVMVMGDVTYGACCVDD FTARALGADFLVHYGHSCLIPMDTSAQDFRVLY VFVDIRIDTTHLLDSLRLTFPPATALALVSTIQF VSTLQAAAQELKAEYRVSVPQCKPLSPGEILGC TSPRLSKEVEAVV*VKNGGQVSPRDMRVPWEGA *GSSSRKETKSNAPYL*ARGHTAR*GPNREQTSG LLSLSPLPSPSSRRLCRVGAGIRGPDGG*GWAG NGGNIIGEDGWARPGCSPINLPSGQLTSRSSVS PAA*LF*VMEMLNVV*MQPA*EPTAPPTGTREGS PVPY*WQGGRVAP*LSPTSGALEAVSTGLTPLS LDRPTSGPSPAQIWQPCSPSSTEWHSPCAHVTQ SLPLGSSKCMLEGGTP*VLAIHQNEVWSPRGREG AATGRLSSTLCNLHGLGSYCQGQHVWGHTWYSL G*ASDTLLPSCLILGEFLNIPEPQLLPSVKQVY YTYLGGLGDRTA*TNSQQVLSLCLVHRRHKSNKQ *LLAGHSGSRL*SQHFGRPRQENCICPGV*DQL GEYNETLFS

Frame 2

ALSAFFQRCLFSTTCAGR*WRRWSYPGQRSRAA ETALAEVGPLGAAWPIRSPLRS*RTLSCRQQSG SCLPTTTLRSPRPSGGSNKPRPRRWPCKCRKAS SSLPVPLWISWKGSRRPK*W*WVT*PTGLAVWMT SQRGPWELTSWCTTATVA*FPWTPRPKTSGCCT SLWTSG*TLHTSWTLSASPFPQPLPLPWSAPFS LCRPCRQPPRS*KPSIV*VSHSASPCPLERSWAA HPPDCPKRWRPLCKLKMGAK*VLETCVYPGREP EVHHPGKKPNLMLLTCEPEVTLQGRDQTGSRPQ VYCRFLHCPVHHPEGCAGWGQESEGLMGVEGGLE MVGI*LEKMDGHAQAAAPLIYHPDS*QAEAACL LPPNYFR*WKCLMLCECSQPESRRLPRLGLGKG VPFRTNGREGGSLPDSVPPLGLWRLFPQA*HPCP *TGPHQGLPQPRSGSPAPRAALSGIPPVPTSLS LYPWGLQSVCWREGHPEC*PFIRMKCGLQEGEK ELPQAGYLPRSVIFMGWEATVRDSMSGGTLGTAW VEPQTHCFLAV*Y*ASFLTSLSLSCYLL*NRYT IRIWED*EIGLRELIHSRYLVYAWYTEGTSPIN SSCWPGTVAHACNLNTLGGQGRRIAYVQEFETSL GNIMKPCSL