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Sequences

Sequence HLA-DQA1.cAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGTTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACCAGTTTTACG GTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGAGTTCAGCAA ATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACCGCTGCTACC AATGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTCCTCCTGTGG TCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAAGATCAGTTA CCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGAGCCTGAGATTCCA GCCCCTATGTCAGAGCTCACAGAGACTGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCATGGGCATTGTGGTGGGCACTGTCTTCATCATCCAAGGCC TGCGTTCAGTTGGTGCTTCCAGACACCAAGGGCCATTGTGAATCCCATCCTGGAAGGGAAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTA TGTTTCAATCCAATTTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTT AGCTGACATTAATATTTCTTGCTTCCTTGTGTTCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCC CTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGG ATAAAGGAAATTTGAATCTCAAAAATATCAAAAGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCT TGTCACCTTGAGATAAAAATTCTTTAGGCAGGAAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATA CTTATTCCTCACATAGGGTTAGTGACAATGGGAAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACC TCCTGAATGAAGCTGTACTAGATAACCATGTAGCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGA AACATGCCAATATCTTCAGAAATCCCCAGCCCTTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACA GTTGAGACAATGTAGCAGCAGCAGTGGGTGCTGTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCT CATGGCTCTAAACAGCTATGAAATCCATGAGGATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTA ATGCAATAATTGATACAGTATAGTTTGGTGCAAAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTG AAGTCTCTAACATTTCTGGCCTTACTTTTCTCATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATAT TTAGTCAATGCCTTACACATAGTACATGAACACATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAA GCACTTTTGTTTTTCTCAGCCTCTTAATGATTTAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTT TTCCAGAATGAGAGAGGCTGAGATTGGATTGGTAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATAT ATTCCCTCCTTATGGCCCATAAGTGTTTATTCAAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGG AGAAAATAATTTAAAACACAGACTGGGAATCAGTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCA GGGCAATAAAACTATTCTGTTTGATACCACAATGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAAT GTAAACTATGGACTTTGGGTGATAATGATGTGCCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCT ATGCATGTGTGGGAGCAGAGTGTATCTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGG GAATGGGGGTATGATCTGGGGATGAAACTGTGAAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCT TGCATGCACAGTTAAAAATAGGGTTCGCACTCCTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCC ACTGCGTGGTCCAGTTTCTAACAGGCCACCAACTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTT CTGTGAACCTACAACCGCTTTAAAATAAGGTCTATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTA TGAAAAACAGTCACATTAAAATGCACAACGTGCTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGA ACCCAGCATTTTGGAGTTGTGTGCATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGT CATGCAGAAATCTACAAATGCTGCCCAACTCAGACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTA TTCAAAAAATATTTACGTAATGTTAAAATAGCAGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTA CTATCAATAGGGTTACAGATCTACCTGCCTGATTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAG TGTGACTTCATTAATACTTAATATCACACTATTTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATA GGGGAGGATTGCTTGAAGCCAGGAGTTCAACAGCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTC CTGTAGTCCCAGCTACTCTAGAGGCTGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCA GCCTAGGCAGCAGAGCAGGACTCCATCTCTAAAAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTAC CACATTTAAACTAGGGACTTGAAGAATTAAACATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAA TTTGTGTTATTGTTATTTTCTGGAGTCCAACTAACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTAC TAGATAAACAACTCCATTTCTTCAGCAACAATTCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTA TGAGGCAATCAGAAAAACTGACACCGACTGTATTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACT TTAGATTTTCATAATAAAATAATTATGAATGAAA

HLA-DQA1.F1 (forward primer)
HLA-DQA1.R1 (reverse primer)
Alternative donor and acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGVVADHVASCGVNLYQFY GPSGQYTHEFDGDEQFYVDLERKETAWRWPEFSK FGGFDPQGALRNMAVAKHNLNIMIKRYNSTAAT NEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPV VNITWLSNGQSVTEGVSETSFLSKSDHSFFKISY LTFLPSADEIYDCKVEHWGLDQPLLKHWEPEIP APMSELTETVVCALGLSVGLMGIVVGTVFIIQG LRSVGASRHQGPL*IPSWKGRAD*NYG**LGYSY VSIQFNLISQIIFHVQ*HRSHQVQYSLIIC*FL S*H*YFLLPCVPTLGTATHPSIQATMKLMDTVC PWPRIVIAKILEPKNKSVLISMWLLKV*QRNKLG *RKFESQKYQK*KCILKTLNL*RMMTVEAFLFP CHLEIKIL*AGKEMEVRKTLE*DNNVGV*KGTN TYSSHRVSDNGKRDGSRSHRHI*EP*IEAQSASP PE*SCTR*PCSFPCATLA*RRQYSEYGYRMFLG NMPISSEIPSPFP*PLLTKESMSL*EKP*EEQH S*DNVAAAVGAVSSTGFAISEEKLSQRKWVSSDL MALNSYEIHEDISNHATCISEFKF*LEKKYKTL MQ*LIQYSLVQRTLNPNPGLSTLKLVF*TL*MC EVSNISGLTFLIHNVGVIILSLQSY**NLNNFDI *SMPYT*YMNT*ENIVVIFIINLFKRMDHII*K ALLFFSAS**FRRFKCRAMGEFLFI**LKDIFL FPE*ERLRLDW*ENS*H*KL*YLTLVFNSLRGNI FPPYGP*VFIQGISYTTDLYACLLWGRSEDSSR RK*FKTQTGNQ*AQEI*TSDDHENVHHRAQMIF RAIKLFCLIPQW*KMSLYICSNPQNI*HQELDLM *TMDFG***CANVSS*IIANVPLRWEMLLMGEA MHVWEQSVSGSSPQPFWQQGPVLWKTIFPQIVG GMGV*SGDETVKLFHLRSTSIS*ILIRNMQPRSL ACTVKNRVRTPMRI*CHH*SDGRRGSVGNAGSP TAWSSF*QATNWYWSMARGLGTSGIPLHLLLSF SVNLQPL*NKVYF*KGKEKVTNYDPKCVK*KF*Y EKQSH*NAQRAKKLLAIGFQIYFIYISMIREAR TQHFGVVCICVCVCVCVCVSVI*GVY*MA**PE SCRNLQMLPNSDSFLKQHCGKQI***QYFIKRMY SKNIYVMLK*QN*N*F*KIRVNSSFYQLKM*GL LSIGLQIYLPDLKSCNS*TII*AI*IISDYTHK V*LH*YLISHYLKFTKLVGHRGSCL*S*HFGGQ* GRIA*SQEFNSCLGNKARPCLYNTKIN*CMAAL L*SQLL*RLRQEECLSPGVQYFSGLRLCHCAHS SLGSRAGLHL*K*INK*NLQNFKNQMKYVRFVPT TFKLGT*RIKHFITNEALHAQTGT**VVDRC*Q FVLLLFSGVQLTNPTVNDITGMQPTRSRIWKLL LDKQLHFFSNNSREREKRSYTF*KAEEIYEPNLY EAIRKTDTDCIKELSNFSVVMRLLLCFLKSHYT LDFHNKIIMNE

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVELWLTTLPLVV*TCTSFT VPLASTPMNLMEMSSSTWTWRGRRLPGGGLSSA NLEVLTRRVH*ETWLWQNTT*TS*LNATTLPLLP MRFLRSQCFPSLP*HWVSPTPSFVLWTTSFLLW STSHG*AMGSQSQKVFLRPASSPRVIIPSSRSV TSPSSLLLMRFMTARWSTGAWTSLF*NTGSLRFQ PLCQSSQRLWSVPWGCLWASWALWWALSSSSKA CVQLVLPDTKGHCESHPGREGLTETMANNWGTL MFQSNLTSFPRSFFMSSNTEATKYSIA**YVDFL ADINISCFLVFPPLALPPTPQFRQQ*N*WIPSA LGPELL*QKF*NQKISLY*FQCGF*KYDREIS* DKGNLNLKNIKSKNVFSKL*IYEE**Q*KPSSSL VTLR*KFFRQEKKWKSEKH*NKTIMWVSEKEQI LIPHIGLVTMGKGTGVEATDISRSPE*RRSLPH LLNEAVLDNHVAFPVPLWHEGDSIVNMATGCFLE TCQYLQKSPALSPNPS*LRKA*AYERNPRKNNT VETM*QQQWVLCPPLDSPSPRRNSHRGNGSAAT SWL*TAMKSMRIFLTMLPASVSLNFNWRKNTKH* CNN*YSIVWCKEP*IQIQDSVL*S*YFKLYKCV KSLTFLALLFSSTM*E**YFPCRVIDKI*IILI FSQCLTHST*THKKTLWLYL*LIYLKEWIILYEK HFCFSQPLNDLGDSNVELWVNFFSYDN*RIFFF FQNERG*DWIGKRTLSTRSCNI*LWFSTL*EGI YSLLMAHKCLFKVYHIQQIFMPVYFGEEVKIVQG ENNLKHRLGISKHRKSEPVMIMKMSITEHR*FS GQ*NYSV*YHNGEKCHYTFAQIHRIYNTKS*T* CKLWTLGDNDVPM*VHKL*QMYHSDGRCC*WGRL CMCGSRVYLAAVPSLFGSRDQFYGRQFFHR*LG EWGYDLGMKL*NYSTSDQQALVRFS*GTCNLDL LHAQLKIGFALL*ESNATTDLTEGGAQLVMLAHP LRGPVSNRPPTGTGPWPGGWGPLGYLCTFCSVF L*TYNRFKIRSIFKKEKRR*PIMILNV*NKNFS MKNSHIKMHNVLRSF*Q*GFKYISYTFQ*FVRQE PSILELCAFVCVCVCVCVCL*YKGYTEWHNDQS HAEIYKCCPTQTPSSSSTVESKFNDSSILLKGC IQKIFT*C*NSRIKTNSKK*E*IVLFIS*KCRAY YQ*GYRSTCLI*NHAILKQLFELFELFQITHIK CDFINT*YHTI*NLQN*WVTEARACDLSTLEAN RGGLLEARSSTAAWATKQDLVSTTQK*INAWRHS CSPSYSRG*GKRSA*AQEFNTSVG*DCATVLTP A*AAEQDSISKSK*INKTYKILKIK*NMSGLYL PHLN*GLEELNILLQMKHFMHRLAHSK*SIGVNN LCYCYFLESN*QIPQ*MTSQGCNQQDPEYGNFY *INNSISSATIQERERREAIHFKRLKKYMNQIC MRQSEKLTPTVLRNYLILVW**DCCYVF*KVIIL *IFIIK*L*MK

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWSCG*PRCLLWCKLVPVLR SLWPVHP*I*WR*AVLRGPGEEGDCLAVA*VQQ IWRF*PAGCTEKHGCGKTQLEHHD*TLQLYRCY Q*GS*GHSVFQVSRDTGSAQHPHLSCGQHLSSCG QHHMAEQWAVSHRRCF*DQLPLQE*SFLLQDQL PHLPPFC**DL*LQGGALGPGPASSETLGA*DS SPYVRAHRDCGLCPGVVCGPHGHCGGHCLHHPRP AFSWCFQTPRAIVNPILEGKG*LKLWLIIGVLL CFNPI*PHFPDHFSCPVTQKPPSTV*PDNMLIS *LTLIFLASLCSHPWHCHPPLNSGNNEINGYRLP LAQNCYSKNFRTKK*VCTNFNVAFKSMTEK*VR IKEI*ISKISKVKMYSQNFKFMKNDDSRSLPLP LSP*DKNSLGRKRNGSQKNIRIRQ*CGCLKRNKY LFLT*G**QWEKGRE*KPQTYLGALNRGAVCLT S*MKLY*ITM*LSLCHSGMKETV**IWLQDVSW KHANIFRNPQPFPLTPPD*GKHELMRETLGRTTQ LRQCSSSSGCCVLHWIRHLRGETLTEEMGQQRP HGSKQL*NP*GYF*PCYLHQ*V*ILIGEKIQNI NAIIDTV*FGAKNPKSKSRTQYFEASILNFINV* SL*HFWPYFSHPQCRSNNTFLAELLIKFE*F*Y LVNALHIVHEHIRKHCGYIYN*FI*KNGSYYMK STFVFLSLLMI*EIQM*SYG*ISFHMIIEGYFSF SRMREAEIGLVRELLALEVVIFDFGFQLSKREY IPSLWPISVYSRYIIYNRSLCLFTLGKK*R*FK EKII*NTDWESVSTGNLNQ**S*KCPSQSTDDFQ GNKTILFDTTMVKNVIIHLLKSTEYITPRVRLN VNYGLWVIMMCQCKFINYSKCTTQMGDVANGGG YACVGAECIWQQSPAFLAAGTSFMEDNFSTDSWG NGGMIWG*NCETIPPQINKH*LDSHKEHAT*IS CMHS*K*GSHSYENLMPPLI*RKAGLSW*CWLT HCVVQFLTGHQLVLVHGPGVGDLWDTSAPSAQFF CEPTTALK*GLFLKRKREGNQL*S*MCKIKILV *KTVTLKCTTC*EAFSNRVSNIFHIHFNDS*GK NPAFWSCVHLCVCVCVCVCVCNIRGILNGIMTRV MQKSTNAAQLRLLPQAALWKANLMIAVFY*KDV FKKYLRNVKIAELKLILKNKSK*FFLSAKNVGP TINRVTDLPA*FKIMQFLNNYLSYLNYFRLHT*S VTSLILNITLFKIYKISGSQRLVLVILALWRPI GEDCLKPGVQQLPGQQSKTLSLQHKNKLMHGGT PVVPATLEAEARGVLEPRSSILQWAKIVPLCSLQ PRQQSRTPSLKVNK*IKLTKF*KSNEICQVCTY HI*TRDLKN*TFYYK*STSCTDWHIVSSR*VLT ICVIVIFWSPTNKSHSE*HHRDATNKIQNMETST R*TTPFLQQQFKREREEKLYILKG*RNI*TKFV *GNQKN*HRLY*GII*F*CGNEIAVMFSKKSLY FRFS**NNYE*

Sequence HLA-DQA1.jAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGGTATGCGTCCACCATTCTGCCTCTCTTTACTTAAGTTATCCCTCCATACCAGGGTTCATTATTTTCTTCCCAAGAGGTCCCCAGATC TTCTTATGGCAATTGCTGAAATTTTATCATCTCCCATCTCTAAAATCACATATTCCCATGTAATACAAGGGTCTTTCCATTATGCATTCAGCAAATCCTT CTAGGAGAGGTCTCATCAACCTCCTACTTTATTAAACATGCCCACAGAGAGAAGGGCACAGGAATAAAGCAGAGGCAATGTGTCGTTGCTCCCAAGCAGA AGGTAAATAAGACCTCTTTGACTATCAGGTGGTGAAATGCTGGTAGGAGGGCTCTTCCAGGATGTAATGCAGAACTTCAGGGCAGAGCTATTCACACTTC ACACCAGTGCTGTTTCCTCACCACAGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTG GACAACATCTTTCCTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATC ATTCCTTCTTCAAGATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAA ACACTGGGAGCCTGAGATTCCAGCCCCTATGTCAGAGCTCACAGAGACTGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCATGGGCATTGTGGTGGGC ACTGTCTTCATCATCCAAGGCCTGCGTTCAGTTGGTGCTTCCAGACACCAAGGGCCATTGTGAGTGCATCGCCATCTACAGGAGCAGAAGAATGGACTTG CTAAATGACCTAGCACTATTCTCTGGCCCGATTTATCATATCCCTTTTCTCCTCCAAATATTTCTCCTCTCACCTTTTCTCTGGGACTTAAGCTGCTATA TCCCCTCAGAGCTCACAAATGCCTTTACATTCTTTCCCTGACCTCCTGATTTTTTTTTTCTTTTCTCAAATGTTACCTACAAAGACATGCCTGGGGTAAG CCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATCTATGTCAAATTTTTCCATCTTTCAT CCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAG AAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGTTCCCACCCTTGGCACTGCCACCCAC CCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTACTAA TTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAATATCAAAAGTAAAAATGTATTCTCAAAACTTT AAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTTAGGCAGGAAAAGAAATGGAAGTCAGAAAAACA TTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGACAATGGGAAAAGGGACGGGAGTAGAAGCCACA GACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAACCATGTAGCTTTCCCTGTGCCACTCTGGCATG AAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCCCCAGCCCTTTCCCCTAACCCCTCCTGACTAAG GAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGTGGGTGCTGTGTCCTCCACTGGATTCGCCATCT CCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATCCATGAGGATATTTCTAACCATGCTACCTGCAT CAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTTTGGTGCAAAGAACCCTAAATCCAAATCCAGGA CTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTACTTTTCTCATCCACAATGTAGGAGTAATAATAC TTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTACATGAACACATAAGAAAACATTGTGGTTATATT TATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTTAATGATTTAGGAGATTCAAATGTAGAGCTATG GGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATTGGATTGGTAAGAGAACTCTTAGCACTAGAAGT TGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTGTTTATTCAAGGTATATCATATACAACAGATCT TTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTGGGAATCAGTAAGCACAGGAAATCTGAACCAGT GATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGATACCACAATGGTGAAAAATGTCATTATACATTT GCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAATGATGTGCCAATGTAAGTTCATAAATTATAGC AAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTATCTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAG GGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGAAACTGTGAAACTATTCCACCTCAGATCAACAA GCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTTCGCACTCCTATGAGAATCTAATGCCACCACTG ATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGGCCACCAACTGGTACTGGTCCATGGCCCGGGGG TTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAATAAGGTCTATTTTTAAAAAGGAAAAGAGAAGG TAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCACAACGTGCTAAGAAGCTTTTAGCAATAGGGTT TCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCCCAACTCAGACTCCTTCCTCAAGCAGCACTGTG GAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTAAAATAGCAGAATTAAAACTAATTCTAAAAAAT AAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACCTGCCTGATTTAAAATCATGCAATTCTTAAACA ATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATCACACTATTTAAAATTTACAAAATTAGTGGGTC ACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAGTTCAACAGCTGCCTGGGCAACAAAGCAAGACC TTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGCTGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTT CAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCATCTCTAAAAGTAAATAAATAAATAAAACTTAC AAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGAATTAAACATTTTATTACAAATGAAGCACTTCA TGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAGTCCAACTAACAAATCCCACAGTGAATGACATC ACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAGCAACAATTCAAGAGAGAGAGAGAAGAGAAGCT ATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACCGACTGTATTAAGGAATTATCTAATTTTAGTGT GGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTATGAATGAAA

HLA-DQA1.F1 (forward primer)
HLA-DQA1.R1 (reverse primer)
Alternative donor and acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNGMRPPFCLSLLKLSLHTRVHYFLPKRSPD LLMAIAEILSSPISKITYSHVIQGSFHYAFSKSF *ERSHQPPTLLNMPTERRAQE*SRGNVSLLPSR R*IRPL*LSGGEMLVGGLFQDVMQNFRAELFTL HTSAVSSPQRFLRSQCFPSLP*HWVSPTPSFVLW TTSFLLWSTSHG*AMGSQSQKVFLRPASSPRVI IPSSRSVTSPSSLLLMRFMTARWSTGAWTSLF* NTGSLRFQPLCQSSQRLWSVPWGCLWASWALWWA LSSSSKACVQLVLPDTKGHCECIAIYRSRRMDL LNDLALFSGPIYHIPFLLQIFLLSPFLWDLSCY IPSELTNAFTFFP*PPDFFFLFSNVTYKDMPGVS HPAT*FLSNLHLKSPRKQ*IPFMRSMSNFSIFH PGLTETMANNWGTLMFQSNLTSFPRSFFMSSNT EATKYSIA**YVDFLADINISCFLVFPPLALPPT PQFRQQ*N*WIPSALGPELL*QKF*NQKISLY* FQCGF*KYDREIS*DKGNLNLKNIKSKNVFSKL *IYEE**Q*KPSSSLVTLR*KFFRQEKKWKSEKH *NKTIMWVSEKEQILIPHIGLVTMGKGTGVEAT DISRSPE*RRSLPHLLNEAVLDNHVAFPVPLWH EGDSIVNMATGCFLETCQYLQKSPALSPNPS*LR KA*AYERNPRKNNTVETM*QQQWVLCPPLDSPS PRRNSHRGNGSAATSWL*TAMKSMRIFLTMLPA SVSLNFNWRKNTKH*CNN*YSIVWCKEP*IQIQD SVL*S*YFKLYKCVKSLTFLALLFSSTM*E**Y FPCRVIDKI*IILIFSQCLTHST*THKKTLWLY L*LIYLKEWIILYEKHFCFSQPLNDLGDSNVELW VNFFSYDN*RIFFFFQNERG*DWIGKRTLSTRS CNI*LWFSTL*EGIYSLLMAHKCLFKVYHIQQI FMPVYFGEEVKIVQGENNLKHRLGISKHRKSEPV MIMKMSITEHR*FSGQ*NYSV*YHNGEKCHYTF AQIHRIYNTKS*T*CKLWTLGDNDVPM*VHKL* QMYHSDGRCC*WGRLCMCGSRVYLAAVPSLFGSR DQFYGRQFFHR*LGEWGYDLGMKL*NYSTSDQQ ALVRFS*GTCNLDLLHAQLKIGFALL*ESNATT DLTEGGAQLVMLAHPLRGPVSNRPPTGTGPWPGG WGPLGYLCTFCSVFL*TYNRFKIRSIFKKEKRR *PIMILNV*NKNFSMKNSHIKMHNVLRSF*Q*G FKYISYTFQ*FVRQEPSILELCAFVCVCVCVCVC L*YKGYTEWHNDQSHAEIYKCCPTQTPSSSSTV ESKFNDSSILLKGCIQKIFT*C*NSRIKTNSKK *E*IVLFIS*KCRAYYQ*GYRSTCLI*NHAILKQ LFELFELFQITHIKCDFINT*YHTI*NLQN*WV TEARACDLSTLEANRGGLLEARSSTAAWATKQD LVSTTQK*INAWRHSCSPSYSRG*GKRSA*AQEF NTSVG*DCATVLTPA*AAEQDSISKSK*INKTY KILKIK*NMSGLYLPHLN*GLEELNILLQMKHF MHRLAHSK*SIGVNNLCYCYFLESN*QIPQ*MTS QGCNQQDPEYGNFY*INNSISSATIQERERREA IHFKRLKKYMNQICMRQSEKLTPTVLRNYLILV W**DCCYVF*KVIIL*IFIIK*L*MK

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMVCVHHSASLYLSYPSIPGFIIFFPRGPQI FLWQLLKFYHLPSLKSHIPM*YKGLSIMHSANP SRRGLINLLLY*TCPQREGHRNKAEAMCRCSQAE GK*DLFDYQVVKCW*EGSSRM*CRTSGQSYSHF TPVLFPHHRGS*GHSVFQVSRDTGSAQHPHLSC GQHLSSCGQHHMAEQWAVSHRRCF*DQLPLQE*S FLLQDQLPHLPPFC**DL*LQGGALGPGPASSE TLGA*DSSPYVRAHRDCGLCPGVVCGPHGHCGG HCLHHPRPAFSWCFQTPRAIVSASPSTGAEEWTC *MT*HYSLARFIISLFSSKYFSSHLFSGT*AAI SPQSSQMPLHSFPDLLIFFFFSQMLPTKTCLG* ATRLPNSSVTSI*NLQGSNKFLL*DLCQIFPSFI QG*LKLWLIIGVLLCFNPI*PHFPDHFSCPVTQ KPPSTV*PDNMLIS*LTLIFLASLCSHPWHCHP PLNSGNNEINGYRLPLAQNCYSKNFRTKK*VCTN FNVAFKSMTEK*VRIKEI*ISKISKVKMYSQNF KFMKNDDSRSLPLPLSP*DKNSLGRKRNGSQKN IRIRQ*CGCLKRNKYLFLT*G**QWEKGRE*KPQ TYLGALNRGAVCLTS*MKLY*ITM*LSLCHSGM KETV**IWLQDVSWKHANIFRNPQPFPLTPPD* GKHELMRETLGRTTQLRQCSSSSGCCVLHWIRHL RGETLTEEMGQQRPHGSKQL*NP*GYF*PCYLH Q*V*ILIGEKIQNINAIIDTV*FGAKNPKSKSR TQYFEASILNFINV*SL*HFWPYFSHPQCRSNNT FLAELLIKFE*F*YLVNALHIVHEHIRKHCGYI YN*FI*KNGSYYMKSTFVFLSLLMI*EIQM*SY G*ISFHMIIEGYFSFSRMREAEIGLVRELLALEV VIFDFGFQLSKREYIPSLWPISVYSRYIIYNRS LCLFTLGKK*R*FKEKII*NTDWESVSTGNLNQ **S*KCPSQSTDDFQGNKTILFDTTMVKNVIIHL LKSTEYITPRVRLNVNYGLWVIMMCQCKFINYS KCTTQMGDVANGGGYACVGAECIWQQSPAFLAA GTSFMEDNFSTDSWGNGGMIWG*NCETIPPQINK H*LDSHKEHAT*ISCMHS*K*GSHSYENLMPPL I*RKAGLSW*CWLTHCVVQFLTGHQLVLVHGPG VGDLWDTSAPSAQFFCEPTTALK*GLFLKRKREG NQL*S*MCKIKILV*KTVTLKCTTC*EAFSNRV SNIFHIHFNDS*GKNPAFWSCVHLCVCVCVCVC VCNIRGILNGIMTRVMQKSTNAAQLRLLPQAALW KANLMIAVFY*KDVFKKYLRNVKIAELKLILKN KSK*FFLSAKNVGPTINRVTDLPA*FKIMQFLN NYLSYLNYFRLHT*SVTSLILNITLFKIYKISGS QRLVLVILALWRPIGEDCLKPGVQQLPGQQSKT LSLQHKNKLMHGGTPVVPATLEAEARGVLEPRS SILQWAKIVPLCSLQPRQQSRTPSLKVNK*IKLT KF*KSNEICQVCTYHI*TRDLKN*TFYYK*STS CTDWHIVSSR*VLTICVIVIFWSPTNKSHSE*H HRDATNKIQNMETSTR*TTPFLQQQFKREREEKL YILKG*RNI*TKFV*GNQKN*HRLY*GII*F*C GNEIAVMFSKKSLYFRFS**NNYE*

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQWYASTILPLFT*VIPPYQGSLFSSQEVPRS SYGNC*NFIISHL*NHIFPCNTRVFPLCIQQIL LGEVSSTSYFIKHAHREKGTGIKQRQCVVAPKQ KVNKTSLTIRW*NAGRRALPGCNAELQGRAIHTS HQCCFLTTEVPEVTVFSKSPVTLGQPNTLICLV DNIFPPVVNITWLSNGQSVTEGVSETSFLSKSD HSFFKISYLTFLPSADEIYDCKVEHWGLDQPLLK HWEPEIPAPMSELTETVVCALGLSVGLMGIVVG TVFIIQGLRSVGASRHQGPL*VHRHLQEQKNGL AK*PSTILWPDLSYPFSPPNISPLTFSLGLKLLY PLRAHKCLYILSLTS*FFFSFLKCYLQRHAWGK PPGYLIPQ*PPSKISKEAINSFYEIYVKFFHLS SRAD*NYG**LGYSYVSIQFNLISQIIFHVQ*HR SHQVQYSLIIC*FLS*H*YFLLPCVPTLGTATH PSIQATMKLMDTVCPWPRIVIAKILEPKNKSVL ISMWLLKV*QRNKLG*RKFESQKYQK*KCILKTL NL*RMMTVEAFLFPCHLEIKIL*AGKEMEVRKT LE*DNNVGV*KGTNTYSSHRVSDNGKRDGSRSH RHI*EP*IEAQSASPPE*SCTR*PCSFPCATLA* RRQYSEYGYRMFLGNMPISSEIPSPFP*PLLTK ESMSL*EKP*EEQHS*DNVAAAVGAVSSTGFAI SEEKLSQRKWVSSDLMALNSYEIHEDISNHATCI SEFKF*LEKKYKTLMQ*LIQYSLVQRTLNPNPG LSTLKLVF*TL*MCEVSNISGLTFLIHNVGVII LSLQSY**NLNNFDI*SMPYT*YMNT*ENIVVIF IINLFKRMDHII*KALLFFSAS**FRRFKCRAM GEFLFI**LKDIFLFPE*ERLRLDW*ENS*H*K L*YLTLVFNSLRGNIFPPYGP*VFIQGISYTTDL YACLLWGRSEDSSRRK*FKTQTGNQ*AQEI*TS DDHENVHHRAQMIFRAIKLFCLIPQW*KMSLYI CSNPQNI*HQELDLM*TMDFG***CANVSS*IIA NVPLRWEMLLMGEAMHVWEQSVSGSSPQPFWQQ GPVLWKTIFPQIVGGMGV*SGDETVKLFHLRST SIS*ILIRNMQPRSLACTVKNRVRTPMRI*CHH* SDGRRGSVGNAGSPTAWSSF*QATNWYWSMARG LGTSGIPLHLLLSFSVNLQPL*NKVYF*KGKEK VTNYDPKCVK*KF*YEKQSH*NAQRAKKLLAIGF QIYFIYISMIREARTQHFGVVCICVCVCVCVCV SVI*GVY*MA**PESCRNLQMLPNSDSFLKQHC GKQI***QYFIKRMYSKNIYVMLK*QN*N*F*KI RVNSSFYQLKM*GLLSIGLQIYLPDLKSCNS*T II*AI*IISDYTHKV*LH*YLISHYLKFTKLVG HRGSCL*S*HFGGQ*GRIA*SQEFNSCLGNKARP CLYNTKIN*CMAALL*SQLL*RLRQEECLSPGV QYFSGLRLCHCAHSSLGSRAGLHL*K*INK*NL QNFKNQMKYVRFVPTTFKLGT*RIKHFITNEALH AQTGT**VVDRC*QFVLLLFSGVQLTNPTVNDI TGMQPTRSRIWKLLLDKQLHFFSNNSREREKRS YTF*KAEEIYEPNLYEAIRKTDTDCIKELSNFSV VMRLLLCFLKSHYTLDFHNKIIMNE