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Sequences

Sequence HLA-DQA1.cAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGTTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACCAGTTTTACG GTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGAGTTCAGCAA ATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACCGCTGCTACC AATGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTCCTCCTGTGG TCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAAGATCAGTTA CCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGAGCCTGAGATTCCA GCCCCTATGTCAGAGCTCACAGAGACTGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCATGGGCATTGTGGTGGGCACTGTCTTCATCATCCAAGGCC TGCGTTCAGTTGGTGCTTCCAGACACCAAGGGCCATTGTGAATCCCATCCTGGAAGGGAAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTA TGTTTCAATCCAATTTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTT AGCTGACATTAATATTTCTTGCTTCCTTGTGTTCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCC CTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGG ATAAAGGAAATTTGAATCTCAAAAATATCAAAAGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCT TGTCACCTTGAGATAAAAATTCTTTAGGCAGGAAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATA CTTATTCCTCACATAGGGTTAGTGACAATGGGAAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACC TCCTGAATGAAGCTGTACTAGATAACCATGTAGCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGA AACATGCCAATATCTTCAGAAATCCCCAGCCCTTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACA GTTGAGACAATGTAGCAGCAGCAGTGGGTGCTGTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCT CATGGCTCTAAACAGCTATGAAATCCATGAGGATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTA ATGCAATAATTGATACAGTATAGTTTGGTGCAAAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTG AAGTCTCTAACATTTCTGGCCTTACTTTTCTCATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATAT TTAGTCAATGCCTTACACATAGTACATGAACACATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAA GCACTTTTGTTTTTCTCAGCCTCTTAATGATTTAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTT TTCCAGAATGAGAGAGGCTGAGATTGGATTGGTAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATAT ATTCCCTCCTTATGGCCCATAAGTGTTTATTCAAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGG AGAAAATAATTTAAAACACAGACTGGGAATCAGTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCA GGGCAATAAAACTATTCTGTTTGATACCACAATGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAAT GTAAACTATGGACTTTGGGTGATAATGATGTGCCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCT ATGCATGTGTGGGAGCAGAGTGTATCTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGG GAATGGGGGTATGATCTGGGGATGAAACTGTGAAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCT TGCATGCACAGTTAAAAATAGGGTTCGCACTCCTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCC ACTGCGTGGTCCAGTTTCTAACAGGCCACCAACTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTT CTGTGAACCTACAACCGCTTTAAAATAAGGTCTATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTA TGAAAAACAGTCACATTAAAATGCACAACGTGCTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGA ACCCAGCATTTTGGAGTTGTGTGCATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGT CATGCAGAAATCTACAAATGCTGCCCAACTCAGACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTA TTCAAAAAATATTTACGTAATGTTAAAATAGCAGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTA CTATCAATAGGGTTACAGATCTACCTGCCTGATTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAG TGTGACTTCATTAATACTTAATATCACACTATTTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATA GGGGAGGATTGCTTGAAGCCAGGAGTTCAACAGCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTC CTGTAGTCCCAGCTACTCTAGAGGCTGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCA GCCTAGGCAGCAGAGCAGGACTCCATCTCTAAAAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTAC CACATTTAAACTAGGGACTTGAAGAATTAAACATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAA TTTGTGTTATTGTTATTTTCTGGAGTCCAACTAACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTAC TAGATAAACAACTCCATTTCTTCAGCAACAATTCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTA TGAGGCAATCAGAAAAACTGACACCGACTGTATTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACT TTAGATTTTCATAATAAAATAATTATGAATGAAA

HLA-DQA1.F1 (forward primer)
HLA-DQA1.R1 (reverse primer)
Alternative acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGVVADHVASCGVNLYQFY GPSGQYTHEFDGDEQFYVDLERKETAWRWPEFSK FGGFDPQGALRNMAVAKHNLNIMIKRYNSTAAT NEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPV VNITWLSNGQSVTEGVSETSFLSKSDHSFFKISY LTFLPSADEIYDCKVEHWGLDQPLLKHWEPEIP APMSELTETVVCALGLSVGLMGIVVGTVFIIQG LRSVGASRHQGPL*IPSWKGRAD*NYG**LGYSY VSIQFNLISQIIFHVQ*HRSHQVQYSLIIC*FL S*H*YFLLPCVPTLGTATHPSIQATMKLMDTVC PWPRIVIAKILEPKNKSVLISMWLLKV*QRNKLG *RKFESQKYQK*KCILKTLNL*RMMTVEAFLFP CHLEIKIL*AGKEMEVRKTLE*DNNVGV*KGTN TYSSHRVSDNGKRDGSRSHRHI*EP*IEAQSASP PE*SCTR*PCSFPCATLA*RRQYSEYGYRMFLG NMPISSEIPSPFP*PLLTKESMSL*EKP*EEQH S*DNVAAAVGAVSSTGFAISEEKLSQRKWVSSDL MALNSYEIHEDISNHATCISEFKF*LEKKYKTL MQ*LIQYSLVQRTLNPNPGLSTLKLVF*TL*MC EVSNISGLTFLIHNVGVIILSLQSY**NLNNFDI *SMPYT*YMNT*ENIVVIFIINLFKRMDHII*K ALLFFSAS**FRRFKCRAMGEFLFI**LKDIFL FPE*ERLRLDW*ENS*H*KL*YLTLVFNSLRGNI FPPYGP*VFIQGISYTTDLYACLLWGRSEDSSR RK*FKTQTGNQ*AQEI*TSDDHENVHHRAQMIF RAIKLFCLIPQW*KMSLYICSNPQNI*HQELDLM *TMDFG***CANVSS*IIANVPLRWEMLLMGEA MHVWEQSVSGSSPQPFWQQGPVLWKTIFPQIVG GMGV*SGDETVKLFHLRSTSIS*ILIRNMQPRSL ACTVKNRVRTPMRI*CHH*SDGRRGSVGNAGSP TAWSSF*QATNWYWSMARGLGTSGIPLHLLLSF SVNLQPL*NKVYF*KGKEKVTNYDPKCVK*KF*Y EKQSH*NAQRAKKLLAIGFQIYFIYISMIREAR TQHFGVVCICVCVCVCVCVSVI*GVY*MA**PE SCRNLQMLPNSDSFLKQHCGKQI***QYFIKRMY SKNIYVMLK*QN*N*F*KIRVNSSFYQLKM*GL LSIGLQIYLPDLKSCNS*TII*AI*IISDYTHK V*LH*YLISHYLKFTKLVGHRGSCL*S*HFGGQ* GRIA*SQEFNSCLGNKARPCLYNTKIN*CMAAL L*SQLL*RLRQEECLSPGVQYFSGLRLCHCAHS SLGSRAGLHL*K*INK*NLQNFKNQMKYVRFVPT TFKLGT*RIKHFITNEALHAQTGT**VVDRC*Q FVLLLFSGVQLTNPTVNDITGMQPTRSRIWKLL LDKQLHFFSNNSREREKRSYTF*KAEEIYEPNLY EAIRKTDTDCIKELSNFSVVMRLLLCFLKSHYT LDFHNKIIMNE

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVELWLTTLPLVV*TCTSFT VPLASTPMNLMEMSSSTWTWRGRRLPGGGLSSA NLEVLTRRVH*ETWLWQNTT*TS*LNATTLPLLP MRFLRSQCFPSLP*HWVSPTPSFVLWTTSFLLW STSHG*AMGSQSQKVFLRPASSPRVIIPSSRSV TSPSSLLLMRFMTARWSTGAWTSLF*NTGSLRFQ PLCQSSQRLWSVPWGCLWASWALWWALSSSSKA CVQLVLPDTKGHCESHPGREGLTETMANNWGTL MFQSNLTSFPRSFFMSSNTEATKYSIA**YVDFL ADINISCFLVFPPLALPPTPQFRQQ*N*WIPSA LGPELL*QKF*NQKISLY*FQCGF*KYDREIS* DKGNLNLKNIKSKNVFSKL*IYEE**Q*KPSSSL VTLR*KFFRQEKKWKSEKH*NKTIMWVSEKEQI LIPHIGLVTMGKGTGVEATDISRSPE*RRSLPH LLNEAVLDNHVAFPVPLWHEGDSIVNMATGCFLE TCQYLQKSPALSPNPS*LRKA*AYERNPRKNNT VETM*QQQWVLCPPLDSPSPRRNSHRGNGSAAT SWL*TAMKSMRIFLTMLPASVSLNFNWRKNTKH* CNN*YSIVWCKEP*IQIQDSVL*S*YFKLYKCV KSLTFLALLFSSTM*E**YFPCRVIDKI*IILI FSQCLTHST*THKKTLWLYL*LIYLKEWIILYEK HFCFSQPLNDLGDSNVELWVNFFSYDN*RIFFF FQNERG*DWIGKRTLSTRSCNI*LWFSTL*EGI YSLLMAHKCLFKVYHIQQIFMPVYFGEEVKIVQG ENNLKHRLGISKHRKSEPVMIMKMSITEHR*FS GQ*NYSV*YHNGEKCHYTFAQIHRIYNTKS*T* CKLWTLGDNDVPM*VHKL*QMYHSDGRCC*WGRL CMCGSRVYLAAVPSLFGSRDQFYGRQFFHR*LG EWGYDLGMKL*NYSTSDQQALVRFS*GTCNLDL LHAQLKIGFALL*ESNATTDLTEGGAQLVMLAHP LRGPVSNRPPTGTGPWPGGWGPLGYLCTFCSVF L*TYNRFKIRSIFKKEKRR*PIMILNV*NKNFS MKNSHIKMHNVLRSF*Q*GFKYISYTFQ*FVRQE PSILELCAFVCVCVCVCVCL*YKGYTEWHNDQS HAEIYKCCPTQTPSSSSTVESKFNDSSILLKGC IQKIFT*C*NSRIKTNSKK*E*IVLFIS*KCRAY YQ*GYRSTCLI*NHAILKQLFELFELFQITHIK CDFINT*YHTI*NLQN*WVTEARACDLSTLEAN RGGLLEARSSTAAWATKQDLVSTTQK*INAWRHS CSPSYSRG*GKRSA*AQEFNTSVG*DCATVLTP A*AAEQDSISKSK*INKTYKILKIK*NMSGLYL PHLN*GLEELNILLQMKHFMHRLAHSK*SIGVNN LCYCYFLESN*QIPQ*MTSQGCNQQDPEYGNFY *INNSISSATIQERERREAIHFKRLKKYMNQIC MRQSEKLTPTVLRNYLILVW**DCCYVF*KVIIL *IFIIK*L*MK

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWSCG*PRCLLWCKLVPVLR SLWPVHP*I*WR*AVLRGPGEEGDCLAVA*VQQ IWRF*PAGCTEKHGCGKTQLEHHD*TLQLYRCY Q*GS*GHSVFQVSRDTGSAQHPHLSCGQHLSSCG QHHMAEQWAVSHRRCF*DQLPLQE*SFLLQDQL PHLPPFC**DL*LQGGALGPGPASSETLGA*DS SPYVRAHRDCGLCPGVVCGPHGHCGGHCLHHPRP AFSWCFQTPRAIVNPILEGKG*LKLWLIIGVLL CFNPI*PHFPDHFSCPVTQKPPSTV*PDNMLIS *LTLIFLASLCSHPWHCHPPLNSGNNEINGYRLP LAQNCYSKNFRTKK*VCTNFNVAFKSMTEK*VR IKEI*ISKISKVKMYSQNFKFMKNDDSRSLPLP LSP*DKNSLGRKRNGSQKNIRIRQ*CGCLKRNKY LFLT*G**QWEKGRE*KPQTYLGALNRGAVCLT S*MKLY*ITM*LSLCHSGMKETV**IWLQDVSW KHANIFRNPQPFPLTPPD*GKHELMRETLGRTTQ LRQCSSSSGCCVLHWIRHLRGETLTEEMGQQRP HGSKQL*NP*GYF*PCYLHQ*V*ILIGEKIQNI NAIIDTV*FGAKNPKSKSRTQYFEASILNFINV* SL*HFWPYFSHPQCRSNNTFLAELLIKFE*F*Y LVNALHIVHEHIRKHCGYIYN*FI*KNGSYYMK STFVFLSLLMI*EIQM*SYG*ISFHMIIEGYFSF SRMREAEIGLVRELLALEVVIFDFGFQLSKREY IPSLWPISVYSRYIIYNRSLCLFTLGKK*R*FK EKII*NTDWESVSTGNLNQ**S*KCPSQSTDDFQ GNKTILFDTTMVKNVIIHLLKSTEYITPRVRLN VNYGLWVIMMCQCKFINYSKCTTQMGDVANGGG YACVGAECIWQQSPAFLAAGTSFMEDNFSTDSWG NGGMIWG*NCETIPPQINKH*LDSHKEHAT*IS CMHS*K*GSHSYENLMPPLI*RKAGLSW*CWLT HCVVQFLTGHQLVLVHGPGVGDLWDTSAPSAQFF CEPTTALK*GLFLKRKREGNQL*S*MCKIKILV *KTVTLKCTTC*EAFSNRVSNIFHIHFNDS*GK NPAFWSCVHLCVCVCVCVCVCNIRGILNGIMTRV MQKSTNAAQLRLLPQAALWKANLMIAVFY*KDV FKKYLRNVKIAELKLILKNKSK*FFLSAKNVGP TINRVTDLPA*FKIMQFLNNYLSYLNYFRLHT*S VTSLILNITLFKIYKISGSQRLVLVILALWRPI GEDCLKPGVQQLPGQQSKTLSLQHKNKLMHGGT PVVPATLEAEARGVLEPRSSILQWAKIVPLCSLQ PRQQSRTPSLKVNK*IKLTKF*KSNEICQVCTY HI*TRDLKN*TFYYK*STSCTDWHIVSSR*VLT ICVIVIFWSPTNKSHSE*HHRDATNKIQNMETST R*TTPFLQQQFKREREEKLYILKG*RNI*TKFV *GNQKN*HRLY*GII*F*CGNEIAVMFSKKSLY FRFS**NNYE*

Sequence HLA-DQA1.aAug05

AAGAGCAAAATAATATGAAAAGTATTTAACAAGGAATATAAAGAATCATCAAAGAAAATGTTATAAAACTTCTTTGAGACCACAAGAGATGATAGAGATG GGGTTTCACTGTGTTAGCGAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCTGCTTCTGCCTCCCAAAGTGCTGGGATTACAGTCGTGAGCCACCGC GCCTGGCCTCCTCATATTATTTTTTATTGTGCAGTTTATTCAAGAGAGCTTTCCAGCACCTGTGATAAGCCTCAGCCCGCCTGCCGGATAATGAGCCCAC ATGGATTGAGAGAGGCCTCCTATCCCTGCCAAACCTATTGATGCTACAGAGATGTGAGGGAGCCCACCTGAGAAAAGCTGAACCTGCCCAGTACATAAAA ACCACTCAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCTCTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGAT GAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACCAGTTTTACGGTCCCTCTGGCCAGTACACCCATGAA TTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGAGTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTG CACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACCGCTGCTACCAATGAGGTTCCTGAGGTCACAGTGTT TTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTCCTCCTGTGGTCAACATCACATGGCTGAGCAATGGG CAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAAGATCAGTTACCTCACCTTCCTCCCTTCTGCTGATG AGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGAGCCTGAGATTCCAGCCCCTATGTCAGAGCTCACAGAGAC TGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCATGGGCATTGTGGTGGGCACTGTCTTCATCATCCAAGGCCTGCGTTCAGTTGGTGCTTCCAGACAC CAAGGGCCATTGTGAATCCCATCCTGGAAGGGAAGTGTTACCTACAAAGACATGCCTGGGGTAAGCCACCCGGCTACCTAATTCCTCAGTAACCTCCATC TAAAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATCTATGTCAAATTTTTCCATCTTTCATCCAGGGCTGACTGAAACTATGGCTAATAATTGGGG TACTCTTATGTTTCAATCCAATTTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTT GATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGTTCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATAC CGTCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAAT AAGTTAGGATAAAGGAAATTTGAATCTCAAAAATATCAAAAGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCC TCTTCCCTTGTCACCTTGAGATAAAAATTCTTTAGGCAGGAAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGG AACAAATACTTATTCCTCACATAGGGTTAGTGACAATGGGAAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCT GCCTCACCTCCTGAATGAAGCTGTACTAGATAACCATGTAGCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGT TTCTTGGAAACATGCCAATATCTTCAGAAATCCCCAGCCCTTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGA ACAACACAGTTGAGACAATGTAGCAGCAGCAGTGGGTGCTGTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGC AGCGACCTCATGGCTCTAAACAGCTATGAAATCCATGAGGATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACA AAACATTAATGCAATAATTGATACAGTATAGTTTGGTGCAAAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATA AATGTGTGAAGTCTCTAACATTTCTGGCCTTACTTTTCTCATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAAT TTTGATATTTAGTCAATGCCTTACACATAGTACATGAACACATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTA TATGAAAAGCACTTTTGTTTTTCTCAGCCTCTTAATGATTTAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATAT TTTTCTTTTTCCAGAATGAGAGAGGCTGAGATTGGATTGGTAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGA GGGAATATATTCCCTCCTTATGGCCCATAAGTGTTTATTCAAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATA GTTCAAGGAGAAAATAATTTAAAACACAGACTGGGAATCAGTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGAT GATTTTCAGGGCAATAAAACTATTCTGTTTGATACCACAATGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTA GACTTAATGTAAACTATGGACTTTGGGTGATAATGATGTGCCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGG GGGAGGCTATGCATGTGTGGGAGCAGAGTGTATCTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGAT AGTTGGGGGAATGGGGGTATGATCTGGGGATGAAACTGTGAAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCT AGATCTCTTGCATGCACAGTTAAAAATAGGGTTCGCACTCCTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTG GCTCACCCACTGCGTGGTCCAGTTTCTAACAGGCCACCAACTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCT CAGTTTTTCTGTGAACCTACAACCGCTTTAAAATAAGGTCTATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAA TTTTAGTATGAAAAACAGTCACATTAAAATGCACAACGTGCTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTG AGGCAAGAACCCAGCATTTTGGAGTTGTGTGCATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATG ACCAGAGTCATGCAGAAATCTACAAATGCTGCCCAACTCAGACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAA AGGATGTATTCAAAAAATATTTACGTAATGTTAAAATAGCAGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGT AGGGCCTACTATCAATAGGGTTACAGATCTACCTGCCTGATTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACAC ACATAAAGTGTGACTTCATTAATACTTAATATCACACTATTTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGA GGCCAATAGGGGAGGATTGCTTGAAGCCAGGAGTTCAACAGCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGG CGGCACTCCTGTAGTCCCAGCTACTCTAGAGGCTGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGC TCACTCCAGCCTAGGCAGCAGAGCAGGACTCCATCTCTAAAAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTT GTACCTACCACATTTAAACTAGGGACTTGAAGAATTAAACATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGT GTTAACAATTTGTGTTATTGTTATTTTCTGGAGTCCAACTAACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAA ACTTCTACTAGATAAACAACTCCATTTCTTCAGCAACAATTCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCA AATTTGTATGAGGCAATCAGAAAAACTGACACCGACTGTATTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTC ATTATACTTTAGATTTTCATAATAAAATAATTATGAATGAAA

HLA-DQA1.F1 (forward primer)
HLA-DQA1.R1 (reverse primer)
Alternative acceptor

Frame 0

KSKII*KVFNKEYKESSKKML*NFFETTRDDRD GVSLC*RGWS*SPDLVIRLLLPPKVLGLQS*ATA PGLLILFFIVQFIQESFPAPVISLSPPAG**AH MD*ERPPIPAKPIDATEM*GSPPEKS*TCPVHK NHSAQNTNC*GCLGKRMILNKALLLGALALTTVM SPCGGEDIVADHVASCGVNLYQFYGPSGQYTHE FDGDEQFYVDLERKETAWRWPEFSKFGGFDPQG ALRNMAVAKHNLNIMIKRYNSTAATNEVPEVTVF SKSPVTLGQPNTLICLVDNIFPPVVNITWLSNG QSVTEGVSETSFLSKSDHSFFKISYLTFLPSAD EIYDCKVEHWGLDQPLLKHWEPEIPAPMSELTET VVCALGLSVGLMGIVVGTVFIIQGLRSVGASRH QGPL*IPSWKGSVTYKDMPGVSHPAT*FLSNLH LKSPRKQ*IPFMRSMSNFSIFHPGLTETMANNWG TLMFQSNLTSFPRSFFMSSNTEATKYSIA**YV DFLADINISCFLVFPPLALPPTPQFRQQ*N*WI PSALGPELL*QKF*NQKISLY*FQCGF*KYDREI S*DKGNLNLKNIKSKNVFSKL*IYEE**Q*KPS SSLVTLR*KFFRQEKKWKSEKH*NKTIMWVSEK EQILIPHIGLVTMGKGTGVEATDISRSPE*RRSL PHLLNEAVLDNHVAFPVPLWHEGDSIVNMATGC FLETCQYLQKSPALSPNPS*LRKA*AYERNPRK NNTVETM*QQQWVLCPPLDSPSPRRNSHRGNGSA ATSWL*TAMKSMRIFLTMLPASVSLNFNWRKNT KH*CNN*YSIVWCKEP*IQIQDSVL*S*YFKLY KCVKSLTFLALLFSSTM*E**YFPCRVIDKI*II LIFSQCLTHST*THKKTLWLYL*LIYLKEWIIL YEKHFCFSQPLNDLGDSNVELWVNFFSYDN*RI FFFFQNERG*DWIGKRTLSTRSCNI*LWFSTL*E GIYSLLMAHKCLFKVYHIQQIFMPVYFGEEVKI VQGENNLKHRLGISKHRKSEPVMIMKMSITEHR *FSGQ*NYSV*YHNGEKCHYTFAQIHRIYNTKS* T*CKLWTLGDNDVPM*VHKL*QMYHSDGRCC*W GRLCMCGSRVYLAAVPSLFGSRDQFYGRQFFHR *LGEWGYDLGMKL*NYSTSDQQALVRFS*GTCNL DLLHAQLKIGFALL*ESNATTDLTEGGAQLVML AHPLRGPVSNRPPTGTGPWPGGWGPLGYLCTFC SVFL*TYNRFKIRSIFKKEKRR*PIMILNV*NKN FSMKNSHIKMHNVLRSF*Q*GFKYISYTFQ*FV RQEPSILELCAFVCVCVCVCVCL*YKGYTEWHN DQSHAEIYKCCPTQTPSSSSTVESKFNDSSILLK GCIQKIFT*C*NSRIKTNSKK*E*IVLFIS*KC RAYYQ*GYRSTCLI*NHAILKQLFELFELFQIT HIKCDFINT*YHTI*NLQN*WVTEARACDLSTLE ANRGGLLEARSSTAAWATKQDLVSTTQK*INAW RHSCSPSYSRG*GKRSA*AQEFNTSVG*DCATV LTPA*AAEQDSISKSK*INKTYKILKIK*NMSGL YLPHLN*GLEELNILLQMKHFMHRLAHSK*SIG VNNLCYCYFLESN*QIPQ*MTSQGCNQQDPEYG NFY*INNSISSATIQERERREAIHFKRLKKYMNQ ICMRQSEKLTPTVLRNYLILVW**DCCYVF*KV IIL*IFIIK*L*MK

Frame 1

RAK*YEKYLTRNIKNHQRKCYKTSLRPQEMIEM GFHCVSEDGLDLLTS*SACFCLPKCWDYSREPP RLASSYYFLLCSLFKRAFQHL**ASARLPDNEPT WIERGLLSLPNLLMLQRCEGAHLRKAEPAQYIK TTQLRTPTAEAALGRG*S*TKLCCWGPSL*PP* *APVEVKTLWLTTLPLVV*TCTSFTVPLASTPMN LMEMSSSTWTWRGRRLPGGGLSSANLEVLTRRV H*ETWLWQNTT*TS*LNATTLPLLPMRFLRSQC FPSLP*HWVSPTPSFVLWTTSFLLWSTSHG*AMG SQSQKVFLRPASSPRVIIPSSRSVTSPSSLLLM RFMTARWSTGAWTSLF*NTGSLRFQPLCQSSQR LWSVPWGCLWASWALWWALSSSSKACVQLVLPDT KGHCESHPGREVLPTKTCLG*ATRLPNSSVTSI *NLQGSNKFLL*DLCQIFPSFIQG*LKLWLIIG VLLCFNPI*PHFPDHFSCPVTQKPPSTV*PDNML IS*LTLIFLASLCSHPWHCHPPLNSGNNEINGY RLPLAQNCYSKNFRTKK*VCTNFNVAFKSMTEK *VRIKEI*ISKISKVKMYSQNFKFMKNDDSRSLP LPLSP*DKNSLGRKRNGSQKNIRIRQ*CGCLKR NKYLFLT*G**QWEKGRE*KPQTYLGALNRGAV CLTS*MKLY*ITM*LSLCHSGMKETV**IWLQDV SWKHANIFRNPQPFPLTPPD*GKHELMRETLGR TTQLRQCSSSSGCCVLHWIRHLRGETLTEEMGQ QRPHGSKQL*NP*GYF*PCYLHQ*V*ILIGEKIQ NINAIIDTV*FGAKNPKSKSRTQYFEASILNFI NV*SL*HFWPYFSHPQCRSNNTFLAELLIKFE* F*YLVNALHIVHEHIRKHCGYIYN*FI*KNGSYY MKSTFVFLSLLMI*EIQM*SYG*ISFHMIIEGY FSFSRMREAEIGLVRELLALEVVIFDFGFQLSK REYIPSLWPISVYSRYIIYNRSLCLFTLGKK*R* FKEKII*NTDWESVSTGNLNQ**S*KCPSQSTD DFQGNKTILFDTTMVKNVIIHLLKSTEYITPRV RLNVNYGLWVIMMCQCKFINYSKCTTQMGDVANG GGYACVGAECIWQQSPAFLAAGTSFMEDNFSTD SWGNGGMIWG*NCETIPPQINKH*LDSHKEHAT *ISCMHS*K*GSHSYENLMPPLI*RKAGLSW*CW LTHCVVQFLTGHQLVLVHGPGVGDLWDTSAPSA QFFCEPTTALK*GLFLKRKREGNQL*S*MCKIK ILV*KTVTLKCTTC*EAFSNRVSNIFHIHFNDS* GKNPAFWSCVHLCVCVCVCVCVCNIRGILNGIM TRVMQKSTNAAQLRLLPQAALWKANLMIAVFY* KDVFKKYLRNVKIAELKLILKNKSK*FFLSAKNV GPTINRVTDLPA*FKIMQFLNNYLSYLNYFRLH T*SVTSLILNITLFKIYKISGSQRLVLVILALW RPIGEDCLKPGVQQLPGQQSKTLSLQHKNKLMHG GTPVVPATLEAEARGVLEPRSSILQWAKIVPLC SLQPRQQSRTPSLKVNK*IKLTKF*KSNEICQV CTYHI*TRDLKN*TFYYK*STSCTDWHIVSSR*V LTICVIVIFWSPTNKSHSE*HHRDATNKIQNME TSTR*TTPFLQQQFKREREEKLYILKG*RNI*T KFV*GNQKN*HRLY*GII*F*CGNEIAVMFSKKS LYFRFS**NNYE*

Frame 2

EQNNMKSI*QGI*RIIKENVIKLL*DHKR**RW GFTVLARMVLIS*PRDPPASASQSAGITVVSHR AWPPHIIFYCAVYSRELSSTCDKPQPACRIMSP HGLREASYPCQTY*CYRDVREPT*EKLNLPST*K PLSSEHQLLRLPWEEDDPKQSSAAGGPRSDHRD EPLWR*RHCG*PRCLLWCKLVPVLRSLWPVHP* I*WR*AVLRGPGEEGDCLAVA*VQQIWRF*PAGC TEKHGCGKTQLEHHD*TLQLYRCYQ*GS*GHSV FQVSRDTGSAQHPHLSCGQHLSSCGQHHMAEQW AVSHRRCF*DQLPLQE*SFLLQDQLPHLPPFC** DL*LQGGALGPGPASSETLGA*DSSPYVRAHRD CGLCPGVVCGPHGHCGGHCLHHPRPAFSWCFQT PRAIVNPILEGKCYLQRHAWGKPPGYLIPQ*PPS KISKEAINSFYEIYVKFFHLSSRAD*NYG**LG YSYVSIQFNLISQIIFHVQ*HRSHQVQYSLIIC *FLS*H*YFLLPCVPTLGTATHPSIQATMKLMDT VCPWPRIVIAKILEPKNKSVLISMWLLKV*QRN KLG*RKFESQKYQK*KCILKTLNL*RMMTVEAF LFPCHLEIKIL*AGKEMEVRKTLE*DNNVGV*KG TNTYSSHRVSDNGKRDGSRSHRHI*EP*IEAQS ASPPE*SCTR*PCSFPCATLA*RRQYSEYGYRM FLGNMPISSEIPSPFP*PLLTKESMSL*EKP*EE QHS*DNVAAAVGAVSSTGFAISEEKLSQRKWVS SDLMALNSYEIHEDISNHATCISEFKF*LEKKY KTLMQ*LIQYSLVQRTLNPNPGLSTLKLVF*TL* MCEVSNISGLTFLIHNVGVIILSLQSY**NLNN FDI*SMPYT*YMNT*ENIVVIFIINLFKRMDHI I*KALLFFSAS**FRRFKCRAMGEFLFI**LKDI FLFPE*ERLRLDW*ENS*H*KL*YLTLVFNSLR GNIFPPYGP*VFIQGISYTTDLYACLLWGRSED SSRRK*FKTQTGNQ*AQEI*TSDDHENVHHRAQM IFRAIKLFCLIPQW*KMSLYICSNPQNI*HQEL DLM*TMDFG***CANVSS*IIANVPLRWEMLLM GEAMHVWEQSVSGSSPQPFWQQGPVLWKTIFPQI VGGMGV*SGDETVKLFHLRSTSIS*ILIRNMQP RSLACTVKNRVRTPMRI*CHH*SDGRRGSVGNA GSPTAWSSF*QATNWYWSMARGLGTSGIPLHLLL SFSVNLQPL*NKVYF*KGKEKVTNYDPKCVK*K F*YEKQSH*NAQRAKKLLAIGFQIYFIYISMIR EARTQHFGVVCICVCVCVCVCVSVI*GVY*MA** PESCRNLQMLPNSDSFLKQHCGKQI***QYFIK RMYSKNIYVMLK*QN*N*F*KIRVNSSFYQLKM *GLLSIGLQIYLPDLKSCNS*TII*AI*IISDYT HKV*LH*YLISHYLKFTKLVGHRGSCL*S*HFG GQ*GRIA*SQEFNSCLGNKARPCLYNTKIN*CM AALL*SQLL*RLRQEECLSPGVQYFSGLRLCHCA HSSLGSRAGLHL*K*INK*NLQNFKNQMKYVRF VPTTFKLGT*RIKHFITNEALHAQTGT**VVDR C*QFVLLLFSGVQLTNPTVNDITGMQPTRSRIWK LLLDKQLHFFSNNSREREKRSYTF*KAEEIYEP NLYEAIRKTDTDCIKELSNFSVVMRLLLCFLKS HYTLDFHNKIIMNE