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Sequences

Sequence HLA-DQA1.gAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTC CTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAA GATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGTGTTA CCTACAAAGACATGCCTGGGGTAAGCCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATC TATGTCAAATTTTTCCATCTTTCATCCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATTTCCCAGA TCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGT TCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTA GAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAATATCAAA AGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTTAGGCAGG AAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGACAATGGG AAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAACCATGTA GCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCCCCAGCCC TTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGTGGGTGCT GTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATCCATGAGG ATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTTTGGTGCA AAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTACTTTTCTC ATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTACATGAACA CATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTTAATGATT TAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATTGGATTGG TAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTGTTTATTC AAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTGGGAATCA GTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGATACCACAA TGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAATGATGTG CCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTATCTGGCAG CAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGAAACTGTG AAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTTCGCACTC CTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGGCCACCAA CTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAATAAGGTC TATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCACAACGTG CTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCATTTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCCCAACTCA GACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTAAAATAGC AGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACCTGCCTGA TTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATCACACTAT TTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAGTTCAACA GCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGCTGAGGCA AGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCATCTCTAA AAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGAATTAAAC ATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAGTCCAACT AACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAGCAACAAT TCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACCGACTGTA TTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTATGAATGA AA

HLA-DQA1.F3 (forward primer)
HLA-DQA1.R3 (reverse primer)
Alternative acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNEVPEVTVFSKSPVTLGQPNTLICLVDNIF PPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFK ISYLTFLPSADEIYDCKVEHWGLDQPLLKHWVL PTKTCLG*ATRLPNSSVTSI*NLQGSNKFLL*D LCQIFPSFIQG*LKLWLIIGVLLCFNPI*PHFPD HFSCPVTQKPPSTV*PDNMLIS*LTLIFLASLC SHPWHCHPPLNSGNNEINGYRLPLAQNCYSKNF RTKK*VCTNFNVAFKSMTEK*VRIKEI*ISKISK VKMYSQNFKFMKNDDSRSLPLPLSP*DKNSLGR KRNGSQKNIRIRQ*CGCLKRNKYLFLT*G**QW EKGRE*KPQTYLGALNRGAVCLTS*MKLY*ITM* LSLCHSGMKETV**IWLQDVSWKHANIFRNPQP FPLTPPD*GKHELMRETLGRTTQLRQCSSSSGC CVLHWIRHLRGETLTEEMGQQRPHGSKQL*NP*G YF*PCYLHQ*V*ILIGEKIQNINAIIDTV*FGA KNPKSKSRTQYFEASILNFINV*SL*HFWPYFS HPQCRSNNTFLAELLIKFE*F*YLVNALHIVHEH IRKHCGYIYN*FI*KNGSYYMKSTFVFLSLLMI *EIQM*SYG*ISFHMIIEGYFSFSRMREAEIGL VRELLALEVVIFDFGFQLSKREYIPSLWPISVYS RYIIYNRSLCLFTLGKK*R*FKEKII*NTDWES VSTGNLNQ**S*KCPSQSTDDFQGNKTILFDTT MVKNVIIHLLKSTEYITPRVRLNVNYGLWVIMMC QCKFINYSKCTTQMGDVANGGGYACVGAECIWQ QSPAFLAAGTSFMEDNFSTDSWGNGGMIWG*NC ETIPPQINKH*LDSHKEHAT*ISCMHS*K*GSHS YENLMPPLI*RKAGLSW*CWLTHCVVQFLTGHQ LVLVHGPGVGDLWDTSAPSAQFFCEPTTALK*G LFLKRKREGNQL*S*MCKIKILV*KTVTLKCTTC *EAFSNRVSNIFHIHFNDS*GKNPAFWSCVHLC VCVCVCVCVCNIRGILNGIMTRVMQKSTNAAQL RLLPQAALWKANLMIAVFY*KDVFKKYLRNVKIA ELKLILKNKSK*FFLSAKNVGPTINRVTDLPA* FKIMQFLNNYLSYLNYFRLHT*SVTSLILNITL FKIYKISGSQRLVLVILALWRPIGEDCLKPGVQQ LPGQQSKTLSLQHKNKLMHGGTPVVPATLEAEA RGVLEPRSSILQWAKIVPLCSLQPRQQSRTPSL KVNK*IKLTKF*KSNEICQVCTYHI*TRDLKN*T FYYK*STSCTDWHIVSSR*VLTICVIVIFWSPT NKSHSE*HHRDATNKIQNMETSTR*TTPFLQQQ FKREREEKLYILKG*RNI*TKFV*GNQKN*HRLY *GII*F*CGNEIAVMFSKKSLYFRFS**NNYE*

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMRFLRSQCFPSLP*HWVSPTPSFVLWTTSF LLWSTSHG*AMGSQSQKVFLRPASSPRVIIPSS RSVTSPSSLLLMRFMTARWSTGAWTSLF*NTGCY LQRHAWGKPPGYLIPQ*PPSKISKEAINSFYEI YVKFFHLSSRAD*NYG**LGYSYVSIQFNLISQ IIFHVQ*HRSHQVQYSLIIC*FLS*H*YFLLPCV PTLGTATHPSIQATMKLMDTVCPWPRIVIAKIL EPKNKSVLISMWLLKV*QRNKLG*RKFESQKYQ K*KCILKTLNL*RMMTVEAFLFPCHLEIKIL*AG KEMEVRKTLE*DNNVGV*KGTNTYSSHRVSDNG KRDGSRSHRHI*EP*IEAQSASPPE*SCTR*PC SFPCATLA*RRQYSEYGYRMFLGNMPISSEIPSP FP*PLLTKESMSL*EKP*EEQHS*DNVAAAVGA VSSTGFAISEEKLSQRKWVSSDLMALNSYEIHE DISNHATCISEFKF*LEKKYKTLMQ*LIQYSLVQ RTLNPNPGLSTLKLVF*TL*MCEVSNISGLTFL IHNVGVIILSLQSY**NLNNFDI*SMPYT*YMN T*ENIVVIFIINLFKRMDHII*KALLFFSAS**F RRFKCRAMGEFLFI**LKDIFLFPE*ERLRLDW *ENS*H*KL*YLTLVFNSLRGNIFPPYGP*VFI QGISYTTDLYACLLWGRSEDSSRRK*FKTQTGNQ *AQEI*TSDDHENVHHRAQMIFRAIKLFCLIPQ W*KMSLYICSNPQNI*HQELDLM*TMDFG***C ANVSS*IIANVPLRWEMLLMGEAMHVWEQSVSGS SPQPFWQQGPVLWKTIFPQIVGGMGV*SGDETV KLFHLRSTSIS*ILIRNMQPRSLACTVKNRVRT PMRI*CHH*SDGRRGSVGNAGSPTAWSSF*QATN WYWSMARGLGTSGIPLHLLLSFSVNLQPL*NKV YF*KGKEKVTNYDPKCVK*KF*YEKQSH*NAQR AKKLLAIGFQIYFIYISMIREARTQHFGVVCICV CVCVCVCVSVI*GVY*MA**PESCRNLQMLPNS DSFLKQHCGKQI***QYFIKRMYSKNIYVMLK* QN*N*F*KIRVNSSFYQLKM*GLLSIGLQIYLPD LKSCNS*TII*AI*IISDYTHKV*LH*YLISHY LKFTKLVGHRGSCL*S*HFGGQ*GRIA*SQEFN SCLGNKARPCLYNTKIN*CMAALL*SQLL*RLRQ EECLSPGVQYFSGLRLCHCAHSSLGSRAGLHL* K*INK*NLQNFKNQMKYVRFVPTTFKLGT*RIK HFITNEALHAQTGT**VVDRC*QFVLLLFSGVQL TNPTVNDITGMQPTRSRIWKLLLDKQLHFFSNN SREREKRSYTF*KAEEIYEPNLYEAIRKTDTDC IKELSNFSVVMRLLLCFLKSHYTLDFHNKIIMNE

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQ*GS*GHSVFQVSRDTGSAQHPHLSCGQHLS SCGQHHMAEQWAVSHRRCF*DQLPLQE*SFLLQ DQLPHLPPFC**DL*LQGGALGPGPASSETLGV TYKDMPGVSHPAT*FLSNLHLKSPRKQ*IPFMRS MSNFSIFHPGLTETMANNWGTLMFQSNLTSFPR SFFMSSNTEATKYSIA**YVDFLADINISCFLV FPPLALPPTPQFRQQ*N*WIPSALGPELL*QKF* NQKISLY*FQCGF*KYDREIS*DKGNLNLKNIK SKNVFSKL*IYEE**Q*KPSSSLVTLR*KFFRQ EKKWKSEKH*NKTIMWVSEKEQILIPHIGLVTMG KGTGVEATDISRSPE*RRSLPHLLNEAVLDNHV AFPVPLWHEGDSIVNMATGCFLETCQYLQKSPA LSPNPS*LRKA*AYERNPRKNNTVETM*QQQWVL CPPLDSPSPRRNSHRGNGSAATSWL*TAMKSMR IFLTMLPASVSLNFNWRKNTKH*CNN*YSIVWC KEP*IQIQDSVL*S*YFKLYKCVKSLTFLALLFS STM*E**YFPCRVIDKI*IILIFSQCLTHST*T HKKTLWLYL*LIYLKEWIILYEKHFCFSQPLND LGDSNVELWVNFFSYDN*RIFFFFQNERG*DWIG KRTLSTRSCNI*LWFSTL*EGIYSLLMAHKCLF KVYHIQQIFMPVYFGEEVKIVQGENNLKHRLGI SKHRKSEPVMIMKMSITEHR*FSGQ*NYSV*YHN GEKCHYTFAQIHRIYNTKS*T*CKLWTLGDNDV PM*VHKL*QMYHSDGRCC*WGRLCMCGSRVYLA AVPSLFGSRDQFYGRQFFHR*LGEWGYDLGMKL* NYSTSDQQALVRFS*GTCNLDLLHAQLKIGFAL L*ESNATTDLTEGGAQLVMLAHPLRGPVSNRPP TGTGPWPGGWGPLGYLCTFCSVFL*TYNRFKIRS IFKKEKRR*PIMILNV*NKNFSMKNSHIKMHNV LRSF*Q*GFKYISYTFQ*FVRQEPSILELCAFV CVCVCVCVCL*YKGYTEWHNDQSHAEIYKCCPTQ TPSSSSTVESKFNDSSILLKGCIQKIFT*C*NS RIKTNSKK*E*IVLFIS*KCRAYYQ*GYRSTCL I*NHAILKQLFELFELFQITHIKCDFINT*YHTI *NLQN*WVTEARACDLSTLEANRGGLLEARSST AAWATKQDLVSTTQK*INAWRHSCSPSYSRG*G KRSA*AQEFNTSVG*DCATVLTPA*AAEQDSISK SK*INKTYKILKIK*NMSGLYLPHLN*GLEELN ILLQMKHFMHRLAHSK*SIGVNNLCYCYFLESN *QIPQ*MTSQGCNQQDPEYGNFY*INNSISSATI QERERREAIHFKRLKKYMNQICMRQSEKLTPTV LRNYLILVW**DCCYVF*KVIIL*IFIIK*L*M K

Sequence HLA-DQA1.fAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTC CTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAA GATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGGTGCA TCGCCATCTACAGGAGCAGAAGAATGGACTTGCTAAATGACCTAGCACTATTCTCTGGCCCGATTTATCATATCCCTTTTCTCCTCCAAATATTTCTCCT CTCACCTTTTCTCTGGGACTTAAGCTGCTATATCCCCTCAGAGCTCACAAATGCCTTTACATTCTTTCCCTGACCTCCTGATTTTTTTTTTCTTTTCTCA AATGTTACCTACAAAGACATGCCTGGGGTAAGCCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTA TGAGATCTATGTCAAATTTTTCCATCTTTCATCCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATT TCCCAGATCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTC CTTGTGTTCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAA AATTTTAGAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAA TATCAAAAGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTT AGGCAGGAAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGA CAATGGGAAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAA CCATGTAGCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCC CCAGCCCTTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGT GGGTGCTGTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATC CATGAGGATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTT TGGTGCAAAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTAC TTTTCTCATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTAC ATGAACACATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTT AATGATTTAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATT GGATTGGTAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTG TTTATTCAAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTG GGAATCAGTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGAT ACCACAATGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAA TGATGTGCCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTAT CTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGA AACTGTGAAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTT CGCACTCCTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGG CCACCAACTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAA TAAGGTCTATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCA CAACGTGCTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCA TTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCC CAACTCAGACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTA AAATAGCAGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACC TGCCTGATTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATC ACACTATTTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAG TTCAACAGCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGC TGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCA TCTCTAAAAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGA ATTAAACATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAG TCCAACTAACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAG CAACAATTCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACC GACTGTATTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTA TGAATGAAA

HLA-DQA1.F3 (forward primer)
HLA-DQA1.R3 (reverse primer)
Alternative acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNEVPEVTVFSKSPVTLGQPNTLICLVDNIF PPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFK ISYLTFLPSADEIYDCKVEHWGLDQPLLKHWGA SPSTGAEEWTC*MT*HYSLARFIISLFSSKYFS SHLFSGT*AAISPQSSQMPLHSFPDLLIFFFFSQ MLPTKTCLG*ATRLPNSSVTSI*NLQGSNKFLL *DLCQIFPSFIQG*LKLWLIIGVLLCFNPI*PH FPDHFSCPVTQKPPSTV*PDNMLIS*LTLIFLAS LCSHPWHCHPPLNSGNNEINGYRLPLAQNCYSK NFRTKK*VCTNFNVAFKSMTEK*VRIKEI*ISK ISKVKMYSQNFKFMKNDDSRSLPLPLSP*DKNSL GRKRNGSQKNIRIRQ*CGCLKRNKYLFLT*G** QWEKGRE*KPQTYLGALNRGAVCLTS*MKLY*I TM*LSLCHSGMKETV**IWLQDVSWKHANIFRNP QPFPLTPPD*GKHELMRETLGRTTQLRQCSSSS GCCVLHWIRHLRGETLTEEMGQQRPHGSKQL*N P*GYF*PCYLHQ*V*ILIGEKIQNINAIIDTV*F GAKNPKSKSRTQYFEASILNFINV*SL*HFWPY FSHPQCRSNNTFLAELLIKFE*F*YLVNALHIV HEHIRKHCGYIYN*FI*KNGSYYMKSTFVFLSLL MI*EIQM*SYG*ISFHMIIEGYFSFSRMREAEI GLVRELLALEVVIFDFGFQLSKREYIPSLWPIS VYSRYIIYNRSLCLFTLGKK*R*FKEKII*NTDW ESVSTGNLNQ**S*KCPSQSTDDFQGNKTILFD TTMVKNVIIHLLKSTEYITPRVRLNVNYGLWVI MMCQCKFINYSKCTTQMGDVANGGGYACVGAECI WQQSPAFLAAGTSFMEDNFSTDSWGNGGMIWG* NCETIPPQINKH*LDSHKEHAT*ISCMHS*K*G SHSYENLMPPLI*RKAGLSW*CWLTHCVVQFLTG HQLVLVHGPGVGDLWDTSAPSAQFFCEPTTALK *GLFLKRKREGNQL*S*MCKIKILV*KTVTLKC TTC*EAFSNRVSNIFHIHFNDS*GKNPAFWSCVH LCVCVCVCVCVCNIRGILNGIMTRVMQKSTNAA QLRLLPQAALWKANLMIAVFY*KDVFKKYLRNV KIAELKLILKNKSK*FFLSAKNVGPTINRVTDLP A*FKIMQFLNNYLSYLNYFRLHT*SVTSLILNI TLFKIYKISGSQRLVLVILALWRPIGEDCLKPG VQQLPGQQSKTLSLQHKNKLMHGGTPVVPATLEA EARGVLEPRSSILQWAKIVPLCSLQPRQQSRTP SLKVNK*IKLTKF*KSNEICQVCTYHI*TRDLK N*TFYYK*STSCTDWHIVSSR*VLTICVIVIFWS PTNKSHSE*HHRDATNKIQNMETSTR*TTPFLQ QQFKREREEKLYILKG*RNI*TKFV*GNQKN*H RLY*GII*F*CGNEIAVMFSKKSLYFRFS**NNY E*

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMRFLRSQCFPSLP*HWVSPTPSFVLWTTSF LLWSTSHG*AMGSQSQKVFLRPASSPRVIIPSS RSVTSPSSLLLMRFMTARWSTGAWTSLF*NTGVH RHLQEQKNGLAK*PSTILWPDLSYPFSPPNISP LTFSLGLKLLYPLRAHKCLYILSLTS*FFFSFL KCYLQRHAWGKPPGYLIPQ*PPSKISKEAINSFY EIYVKFFHLSSRAD*NYG**LGYSYVSIQFNLI SQIIFHVQ*HRSHQVQYSLIIC*FLS*H*YFLL PCVPTLGTATHPSIQATMKLMDTVCPWPRIVIAK ILEPKNKSVLISMWLLKV*QRNKLG*RKFESQK YQK*KCILKTLNL*RMMTVEAFLFPCHLEIKIL *AGKEMEVRKTLE*DNNVGV*KGTNTYSSHRVSD NGKRDGSRSHRHI*EP*IEAQSASPPE*SCTR* PCSFPCATLA*RRQYSEYGYRMFLGNMPISSEI PSPFP*PLLTKESMSL*EKP*EEQHS*DNVAAAV GAVSSTGFAISEEKLSQRKWVSSDLMALNSYEI HEDISNHATCISEFKF*LEKKYKTLMQ*LIQYS LVQRTLNPNPGLSTLKLVF*TL*MCEVSNISGLT FLIHNVGVIILSLQSY**NLNNFDI*SMPYT*Y MNT*ENIVVIFIINLFKRMDHII*KALLFFSAS **FRRFKCRAMGEFLFI**LKDIFLFPE*ERLRL DW*ENS*H*KL*YLTLVFNSLRGNIFPPYGP*V FIQGISYTTDLYACLLWGRSEDSSRRK*FKTQT GNQ*AQEI*TSDDHENVHHRAQMIFRAIKLFCLI PQW*KMSLYICSNPQNI*HQELDLM*TMDFG** *CANVSS*IIANVPLRWEMLLMGEAMHVWEQSV SGSSPQPFWQQGPVLWKTIFPQIVGGMGV*SGDE TVKLFHLRSTSIS*ILIRNMQPRSLACTVKNRV RTPMRI*CHH*SDGRRGSVGNAGSPTAWSSF*Q ATNWYWSMARGLGTSGIPLHLLLSFSVNLQPL*N KVYF*KGKEKVTNYDPKCVK*KF*YEKQSH*NA QRAKKLLAIGFQIYFIYISMIREARTQHFGVVC ICVCVCVCVCVSVI*GVY*MA**PESCRNLQMLP NSDSFLKQHCGKQI***QYFIKRMYSKNIYVML K*QN*N*F*KIRVNSSFYQLKM*GLLSIGLQIY LPDLKSCNS*TII*AI*IISDYTHKV*LH*YLIS HYLKFTKLVGHRGSCL*S*HFGGQ*GRIA*SQE FNSCLGNKARPCLYNTKIN*CMAALL*SQLL*R LRQEECLSPGVQYFSGLRLCHCAHSSLGSRAGLH L*K*INK*NLQNFKNQMKYVRFVPTTFKLGT*R IKHFITNEALHAQTGT**VVDRC*QFVLLLFSG VQLTNPTVNDITGMQPTRSRIWKLLLDKQLHFFS NNSREREKRSYTF*KAEEIYEPNLYEAIRKTDT DCIKELSNFSVVMRLLLCFLKSHYTLDFHNKII MNE

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQ*GS*GHSVFQVSRDTGSAQHPHLSCGQHLS SCGQHHMAEQWAVSHRRCF*DQLPLQE*SFLLQ DQLPHLPPFC**DL*LQGGALGPGPASSETLGC IAIYRSRRMDLLNDLALFSGPIYHIPFLLQIFLL SPFLWDLSCYIPSELTNAFTFFP*PPDFFFLFS NVTYKDMPGVSHPAT*FLSNLHLKSPRKQ*IPF MRSMSNFSIFHPGLTETMANNWGTLMFQSNLTSF PRSFFMSSNTEATKYSIA**YVDFLADINISCF LVFPPLALPPTPQFRQQ*N*WIPSALGPELL*Q KF*NQKISLY*FQCGF*KYDREIS*DKGNLNLKN IKSKNVFSKL*IYEE**Q*KPSSSLVTLR*KFF RQEKKWKSEKH*NKTIMWVSEKEQILIPHIGLV TMGKGTGVEATDISRSPE*RRSLPHLLNEAVLDN HVAFPVPLWHEGDSIVNMATGCFLETCQYLQKS PALSPNPS*LRKA*AYERNPRKNNTVETM*QQQ WVLCPPLDSPSPRRNSHRGNGSAATSWL*TAMKS MRIFLTMLPASVSLNFNWRKNTKH*CNN*YSIV WCKEP*IQIQDSVL*S*YFKLYKCVKSLTFLAL LFSSTM*E**YFPCRVIDKI*IILIFSQCLTHST *THKKTLWLYL*LIYLKEWIILYEKHFCFSQPL NDLGDSNVELWVNFFSYDN*RIFFFFQNERG*D WIGKRTLSTRSCNI*LWFSTL*EGIYSLLMAHKC LFKVYHIQQIFMPVYFGEEVKIVQGENNLKHRL GISKHRKSEPVMIMKMSITEHR*FSGQ*NYSV* YHNGEKCHYTFAQIHRIYNTKS*T*CKLWTLGDN DVPM*VHKL*QMYHSDGRCC*WGRLCMCGSRVY LAAVPSLFGSRDQFYGRQFFHR*LGEWGYDLGM KL*NYSTSDQQALVRFS*GTCNLDLLHAQLKIGF ALL*ESNATTDLTEGGAQLVMLAHPLRGPVSNR PPTGTGPWPGGWGPLGYLCTFCSVFL*TYNRFK IRSIFKKEKRR*PIMILNV*NKNFSMKNSHIKMH NVLRSF*Q*GFKYISYTFQ*FVRQEPSILELCA FVCVCVCVCVCL*YKGYTEWHNDQSHAEIYKCC PTQTPSSSSTVESKFNDSSILLKGCIQKIFT*C* NSRIKTNSKK*E*IVLFIS*KCRAYYQ*GYRST CLI*NHAILKQLFELFELFQITHIKCDFINT*Y HTI*NLQN*WVTEARACDLSTLEANRGGLLEARS STAAWATKQDLVSTTQK*INAWRHSCSPSYSRG *GKRSA*AQEFNTSVG*DCATVLTPA*AAEQDS ISKSK*INKTYKILKIK*NMSGLYLPHLN*GLEE LNILLQMKHFMHRLAHSK*SIGVNNLCYCYFLE SN*QIPQ*MTSQGCNQQDPEYGNFY*INNSISS ATIQERERREAIHFKRLKKYMNQICMRQSEKLTP TVLRNYLILVW**DCCYVF*KVIIL*IFIIK*L *MK