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Sequences

Sequence HLA-DQA1.gAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTC CTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAA GATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGTGTTA CCTACAAAGACATGCCTGGGGTAAGCCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATC TATGTCAAATTTTTCCATCTTTCATCCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATTTCCCAGA TCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGT TCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTA GAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAATATCAAA AGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTTAGGCAGG AAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGACAATGGG AAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAACCATGTA GCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCCCCAGCCC TTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGTGGGTGCT GTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATCCATGAGG ATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTTTGGTGCA AAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTACTTTTCTC ATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTACATGAACA CATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTTAATGATT TAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATTGGATTGG TAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTGTTTATTC AAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTGGGAATCA GTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGATACCACAA TGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAATGATGTG CCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTATCTGGCAG CAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGAAACTGTG AAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTTCGCACTC CTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGGCCACCAA CTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAATAAGGTC TATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCACAACGTG CTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCATTTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCCCAACTCA GACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTAAAATAGC AGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACCTGCCTGA TTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATCACACTAT TTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAGTTCAACA GCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGCTGAGGCA AGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCATCTCTAA AAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGAATTAAAC ATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAGTCCAACT AACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAGCAACAAT TCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACCGACTGTA TTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTATGAATGA AA

HLA-DQA1.F3 (forward primer)
HLA-DQA1.R3 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNEVPEVTVFSKSPVTLGQPNTLICLVDNIF PPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFK ISYLTFLPSADEIYDCKVEHWGLDQPLLKHWVL PTKTCLG*ATRLPNSSVTSI*NLQGSNKFLL*D LCQIFPSFIQG*LKLWLIIGVLLCFNPI*PHFPD HFSCPVTQKPPSTV*PDNMLIS*LTLIFLASLC SHPWHCHPPLNSGNNEINGYRLPLAQNCYSKNF RTKK*VCTNFNVAFKSMTEK*VRIKEI*ISKISK VKMYSQNFKFMKNDDSRSLPLPLSP*DKNSLGR KRNGSQKNIRIRQ*CGCLKRNKYLFLT*G**QW EKGRE*KPQTYLGALNRGAVCLTS*MKLY*ITM* LSLCHSGMKETV**IWLQDVSWKHANIFRNPQP FPLTPPD*GKHELMRETLGRTTQLRQCSSSSGC CVLHWIRHLRGETLTEEMGQQRPHGSKQL*NP*G YF*PCYLHQ*V*ILIGEKIQNINAIIDTV*FGA KNPKSKSRTQYFEASILNFINV*SL*HFWPYFS HPQCRSNNTFLAELLIKFE*F*YLVNALHIVHEH IRKHCGYIYN*FI*KNGSYYMKSTFVFLSLLMI *EIQM*SYG*ISFHMIIEGYFSFSRMREAEIGL VRELLALEVVIFDFGFQLSKREYIPSLWPISVYS RYIIYNRSLCLFTLGKK*R*FKEKII*NTDWES VSTGNLNQ**S*KCPSQSTDDFQGNKTILFDTT MVKNVIIHLLKSTEYITPRVRLNVNYGLWVIMMC QCKFINYSKCTTQMGDVANGGGYACVGAECIWQ QSPAFLAAGTSFMEDNFSTDSWGNGGMIWG*NC ETIPPQINKH*LDSHKEHAT*ISCMHS*K*GSHS YENLMPPLI*RKAGLSW*CWLTHCVVQFLTGHQ LVLVHGPGVGDLWDTSAPSAQFFCEPTTALK*G LFLKRKREGNQL*S*MCKIKILV*KTVTLKCTTC *EAFSNRVSNIFHIHFNDS*GKNPAFWSCVHLC VCVCVCVCVCNIRGILNGIMTRVMQKSTNAAQL RLLPQAALWKANLMIAVFY*KDVFKKYLRNVKIA ELKLILKNKSK*FFLSAKNVGPTINRVTDLPA* FKIMQFLNNYLSYLNYFRLHT*SVTSLILNITL FKIYKISGSQRLVLVILALWRPIGEDCLKPGVQQ LPGQQSKTLSLQHKNKLMHGGTPVVPATLEAEA RGVLEPRSSILQWAKIVPLCSLQPRQQSRTPSL KVNK*IKLTKF*KSNEICQVCTYHI*TRDLKN*T FYYK*STSCTDWHIVSSR*VLTICVIVIFWSPT NKSHSE*HHRDATNKIQNMETSTR*TTPFLQQQ FKREREEKLYILKG*RNI*TKFV*GNQKN*HRLY *GII*F*CGNEIAVMFSKKSLYFRFS**NNYE*

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMRFLRSQCFPSLP*HWVSPTPSFVLWTTSF LLWSTSHG*AMGSQSQKVFLRPASSPRVIIPSS RSVTSPSSLLLMRFMTARWSTGAWTSLF*NTGCY LQRHAWGKPPGYLIPQ*PPSKISKEAINSFYEI YVKFFHLSSRAD*NYG**LGYSYVSIQFNLISQ IIFHVQ*HRSHQVQYSLIIC*FLS*H*YFLLPCV PTLGTATHPSIQATMKLMDTVCPWPRIVIAKIL EPKNKSVLISMWLLKV*QRNKLG*RKFESQKYQ K*KCILKTLNL*RMMTVEAFLFPCHLEIKIL*AG KEMEVRKTLE*DNNVGV*KGTNTYSSHRVSDNG KRDGSRSHRHI*EP*IEAQSASPPE*SCTR*PC SFPCATLA*RRQYSEYGYRMFLGNMPISSEIPSP FP*PLLTKESMSL*EKP*EEQHS*DNVAAAVGA VSSTGFAISEEKLSQRKWVSSDLMALNSYEIHE DISNHATCISEFKF*LEKKYKTLMQ*LIQYSLVQ RTLNPNPGLSTLKLVF*TL*MCEVSNISGLTFL IHNVGVIILSLQSY**NLNNFDI*SMPYT*YMN T*ENIVVIFIINLFKRMDHII*KALLFFSAS**F RRFKCRAMGEFLFI**LKDIFLFPE*ERLRLDW *ENS*H*KL*YLTLVFNSLRGNIFPPYGP*VFI QGISYTTDLYACLLWGRSEDSSRRK*FKTQTGNQ *AQEI*TSDDHENVHHRAQMIFRAIKLFCLIPQ W*KMSLYICSNPQNI*HQELDLM*TMDFG***C ANVSS*IIANVPLRWEMLLMGEAMHVWEQSVSGS SPQPFWQQGPVLWKTIFPQIVGGMGV*SGDETV KLFHLRSTSIS*ILIRNMQPRSLACTVKNRVRT PMRI*CHH*SDGRRGSVGNAGSPTAWSSF*QATN WYWSMARGLGTSGIPLHLLLSFSVNLQPL*NKV YF*KGKEKVTNYDPKCVK*KF*YEKQSH*NAQR AKKLLAIGFQIYFIYISMIREARTQHFGVVCICV CVCVCVCVSVI*GVY*MA**PESCRNLQMLPNS DSFLKQHCGKQI***QYFIKRMYSKNIYVMLK* QN*N*F*KIRVNSSFYQLKM*GLLSIGLQIYLPD LKSCNS*TII*AI*IISDYTHKV*LH*YLISHY LKFTKLVGHRGSCL*S*HFGGQ*GRIA*SQEFN SCLGNKARPCLYNTKIN*CMAALL*SQLL*RLRQ EECLSPGVQYFSGLRLCHCAHSSLGSRAGLHL* K*INK*NLQNFKNQMKYVRFVPTTFKLGT*RIK HFITNEALHAQTGT**VVDRC*QFVLLLFSGVQL TNPTVNDITGMQPTRSRIWKLLLDKQLHFFSNN SREREKRSYTF*KAEEIYEPNLYEAIRKTDTDC IKELSNFSVVMRLLLCFLKSHYTLDFHNKIIMNE

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQ*GS*GHSVFQVSRDTGSAQHPHLSCGQHLS SCGQHHMAEQWAVSHRRCF*DQLPLQE*SFLLQ DQLPHLPPFC**DL*LQGGALGPGPASSETLGV TYKDMPGVSHPAT*FLSNLHLKSPRKQ*IPFMRS MSNFSIFHPGLTETMANNWGTLMFQSNLTSFPR SFFMSSNTEATKYSIA**YVDFLADINISCFLV FPPLALPPTPQFRQQ*N*WIPSALGPELL*QKF* NQKISLY*FQCGF*KYDREIS*DKGNLNLKNIK SKNVFSKL*IYEE**Q*KPSSSLVTLR*KFFRQ EKKWKSEKH*NKTIMWVSEKEQILIPHIGLVTMG KGTGVEATDISRSPE*RRSLPHLLNEAVLDNHV AFPVPLWHEGDSIVNMATGCFLETCQYLQKSPA LSPNPS*LRKA*AYERNPRKNNTVETM*QQQWVL CPPLDSPSPRRNSHRGNGSAATSWL*TAMKSMR IFLTMLPASVSLNFNWRKNTKH*CNN*YSIVWC KEP*IQIQDSVL*S*YFKLYKCVKSLTFLALLFS STM*E**YFPCRVIDKI*IILIFSQCLTHST*T HKKTLWLYL*LIYLKEWIILYEKHFCFSQPLND LGDSNVELWVNFFSYDN*RIFFFFQNERG*DWIG KRTLSTRSCNI*LWFSTL*EGIYSLLMAHKCLF KVYHIQQIFMPVYFGEEVKIVQGENNLKHRLGI SKHRKSEPVMIMKMSITEHR*FSGQ*NYSV*YHN GEKCHYTFAQIHRIYNTKS*T*CKLWTLGDNDV PM*VHKL*QMYHSDGRCC*WGRLCMCGSRVYLA AVPSLFGSRDQFYGRQFFHR*LGEWGYDLGMKL* NYSTSDQQALVRFS*GTCNLDLLHAQLKIGFAL L*ESNATTDLTEGGAQLVMLAHPLRGPVSNRPP TGTGPWPGGWGPLGYLCTFCSVFL*TYNRFKIRS IFKKEKRR*PIMILNV*NKNFSMKNSHIKMHNV LRSF*Q*GFKYISYTFQ*FVRQEPSILELCAFV CVCVCVCVCL*YKGYTEWHNDQSHAEIYKCCPTQ TPSSSSTVESKFNDSSILLKGCIQKIFT*C*NS RIKTNSKK*E*IVLFIS*KCRAYYQ*GYRSTCL I*NHAILKQLFELFELFQITHIKCDFINT*YHTI *NLQN*WVTEARACDLSTLEANRGGLLEARSST AAWATKQDLVSTTQK*INAWRHSCSPSYSRG*G KRSA*AQEFNTSVG*DCATVLTPA*AAEQDSISK SK*INKTYKILKIK*NMSGLYLPHLN*GLEELN ILLQMKHFMHRLAHSK*SIGVNNLCYCYFLESN *QIPQ*MTSQGCNQQDPEYGNFY*INNSISSATI QERERREAIHFKRLKKYMNQICMRQSEKLTPTV LRNYLILVW**DCCYVF*KVIIL*IFIIK*L*M K

Sequence HLA-DQA1.jAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGGTATGCGTCCACCATTCTGCCTCTCTTTACTTAAGTTATCCCTCCATACCAGGGTTCATTATTTTCTTCCCAAGAGGTCCCCAGATC TTCTTATGGCAATTGCTGAAATTTTATCATCTCCCATCTCTAAAATCACATATTCCCATGTAATACAAGGGTCTTTCCATTATGCATTCAGCAAATCCTT CTAGGAGAGGTCTCATCAACCTCCTACTTTATTAAACATGCCCACAGAGAGAAGGGCACAGGAATAAAGCAGAGGCAATGTGTCGTTGCTCCCAAGCAGA AGGTAAATAAGACCTCTTTGACTATCAGGTGGTGAAATGCTGGTAGGAGGGCTCTTCCAGGATGTAATGCAGAACTTCAGGGCAGAGCTATTCACACTTC ACACCAGTGCTGTTTCCTCACCACAGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTG GACAACATCTTTCCTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATC ATTCCTTCTTCAAGATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAA ACACTGGGAGCCTGAGATTCCAGCCCCTATGTCAGAGCTCACAGAGACTGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCATGGGCATTGTGGTGGGC ACTGTCTTCATCATCCAAGGCCTGCGTTCAGTTGGTGCTTCCAGACACCAAGGGCCATTGTGAGTGCATCGCCATCTACAGGAGCAGAAGAATGGACTTG CTAAATGACCTAGCACTATTCTCTGGCCCGATTTATCATATCCCTTTTCTCCTCCAAATATTTCTCCTCTCACCTTTTCTCTGGGACTTAAGCTGCTATA TCCCCTCAGAGCTCACAAATGCCTTTACATTCTTTCCCTGACCTCCTGATTTTTTTTTTCTTTTCTCAAATGTTACCTACAAAGACATGCCTGGGGTAAG CCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATCTATGTCAAATTTTTCCATCTTTCAT CCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAG AAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGTTCCCACCCTTGGCACTGCCACCCAC CCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTACTAA TTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAATATCAAAAGTAAAAATGTATTCTCAAAACTTT AAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTTAGGCAGGAAAAGAAATGGAAGTCAGAAAAACA TTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGACAATGGGAAAAGGGACGGGAGTAGAAGCCACA GACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAACCATGTAGCTTTCCCTGTGCCACTCTGGCATG AAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCCCCAGCCCTTTCCCCTAACCCCTCCTGACTAAG GAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGTGGGTGCTGTGTCCTCCACTGGATTCGCCATCT CCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATCCATGAGGATATTTCTAACCATGCTACCTGCAT CAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTTTGGTGCAAAGAACCCTAAATCCAAATCCAGGA CTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTACTTTTCTCATCCACAATGTAGGAGTAATAATAC TTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTACATGAACACATAAGAAAACATTGTGGTTATATT TATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTTAATGATTTAGGAGATTCAAATGTAGAGCTATG GGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATTGGATTGGTAAGAGAACTCTTAGCACTAGAAGT TGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTGTTTATTCAAGGTATATCATATACAACAGATCT TTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTGGGAATCAGTAAGCACAGGAAATCTGAACCAGT GATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGATACCACAATGGTGAAAAATGTCATTATACATTT GCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAATGATGTGCCAATGTAAGTTCATAAATTATAGC AAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTATCTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAG GGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGAAACTGTGAAACTATTCCACCTCAGATCAACAA GCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTTCGCACTCCTATGAGAATCTAATGCCACCACTG ATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGGCCACCAACTGGTACTGGTCCATGGCCCGGGGG TTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAATAAGGTCTATTTTTAAAAAGGAAAAGAGAAGG TAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCACAACGTGCTAAGAAGCTTTTAGCAATAGGGTT TCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCCCAACTCAGACTCCTTCCTCAAGCAGCACTGTG GAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTAAAATAGCAGAATTAAAACTAATTCTAAAAAAT AAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACCTGCCTGATTTAAAATCATGCAATTCTTAAACA ATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATCACACTATTTAAAATTTACAAAATTAGTGGGTC ACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAGTTCAACAGCTGCCTGGGCAACAAAGCAAGACC TTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGCTGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTT CAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCATCTCTAAAAGTAAATAAATAAATAAAACTTAC AAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGAATTAAACATTTTATTACAAATGAAGCACTTCA TGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAGTCCAACTAACAAATCCCACAGTGAATGACATC ACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAGCAACAATTCAAGAGAGAGAGAGAAGAGAAGCT ATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACCGACTGTATTAAGGAATTATCTAATTTTAGTGT GGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTATGAATGAAA

HLA-DQA1.F3 (forward primer)
HLA-DQA1.R3 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNGMRPPFCLSLLKLSLHTRVHYFLPKRSPD LLMAIAEILSSPISKITYSHVIQGSFHYAFSKSF *ERSHQPPTLLNMPTERRAQE*SRGNVSLLPSR R*IRPL*LSGGEMLVGGLFQDVMQNFRAELFTL HTSAVSSPQRFLRSQCFPSLP*HWVSPTPSFVLW TTSFLLWSTSHG*AMGSQSQKVFLRPASSPRVI IPSSRSVTSPSSLLLMRFMTARWSTGAWTSLF* NTGSLRFQPLCQSSQRLWSVPWGCLWASWALWWA LSSSSKACVQLVLPDTKGHCECIAIYRSRRMDL LNDLALFSGPIYHIPFLLQIFLLSPFLWDLSCY IPSELTNAFTFFP*PPDFFFLFSNVTYKDMPGVS HPAT*FLSNLHLKSPRKQ*IPFMRSMSNFSIFH PGLTETMANNWGTLMFQSNLTSFPRSFFMSSNT EATKYSIA**YVDFLADINISCFLVFPPLALPPT PQFRQQ*N*WIPSALGPELL*QKF*NQKISLY* FQCGF*KYDREIS*DKGNLNLKNIKSKNVFSKL *IYEE**Q*KPSSSLVTLR*KFFRQEKKWKSEKH *NKTIMWVSEKEQILIPHIGLVTMGKGTGVEAT DISRSPE*RRSLPHLLNEAVLDNHVAFPVPLWH EGDSIVNMATGCFLETCQYLQKSPALSPNPS*LR KA*AYERNPRKNNTVETM*QQQWVLCPPLDSPS PRRNSHRGNGSAATSWL*TAMKSMRIFLTMLPA SVSLNFNWRKNTKH*CNN*YSIVWCKEP*IQIQD SVL*S*YFKLYKCVKSLTFLALLFSSTM*E**Y FPCRVIDKI*IILIFSQCLTHST*THKKTLWLY L*LIYLKEWIILYEKHFCFSQPLNDLGDSNVELW VNFFSYDN*RIFFFFQNERG*DWIGKRTLSTRS CNI*LWFSTL*EGIYSLLMAHKCLFKVYHIQQI FMPVYFGEEVKIVQGENNLKHRLGISKHRKSEPV MIMKMSITEHR*FSGQ*NYSV*YHNGEKCHYTF AQIHRIYNTKS*T*CKLWTLGDNDVPM*VHKL* QMYHSDGRCC*WGRLCMCGSRVYLAAVPSLFGSR DQFYGRQFFHR*LGEWGYDLGMKL*NYSTSDQQ ALVRFS*GTCNLDLLHAQLKIGFALL*ESNATT DLTEGGAQLVMLAHPLRGPVSNRPPTGTGPWPGG WGPLGYLCTFCSVFL*TYNRFKIRSIFKKEKRR *PIMILNV*NKNFSMKNSHIKMHNVLRSF*Q*G FKYISYTFQ*FVRQEPSILELCAFVCVCVCVCVC L*YKGYTEWHNDQSHAEIYKCCPTQTPSSSSTV ESKFNDSSILLKGCIQKIFT*C*NSRIKTNSKK *E*IVLFIS*KCRAYYQ*GYRSTCLI*NHAILKQ LFELFELFQITHIKCDFINT*YHTI*NLQN*WV TEARACDLSTLEANRGGLLEARSSTAAWATKQD LVSTTQK*INAWRHSCSPSYSRG*GKRSA*AQEF NTSVG*DCATVLTPA*AAEQDSISKSK*INKTY KILKIK*NMSGLYLPHLN*GLEELNILLQMKHF MHRLAHSK*SIGVNNLCYCYFLESN*QIPQ*MTS QGCNQQDPEYGNFY*INNSISSATIQERERREA IHFKRLKKYMNQICMRQSEKLTPTVLRNYLILV W**DCCYVF*KVIIL*IFIIK*L*MK

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMVCVHHSASLYLSYPSIPGFIIFFPRGPQI FLWQLLKFYHLPSLKSHIPM*YKGLSIMHSANP SRRGLINLLLY*TCPQREGHRNKAEAMCRCSQAE GK*DLFDYQVVKCW*EGSSRM*CRTSGQSYSHF TPVLFPHHRGS*GHSVFQVSRDTGSAQHPHLSC GQHLSSCGQHHMAEQWAVSHRRCF*DQLPLQE*S FLLQDQLPHLPPFC**DL*LQGGALGPGPASSE TLGA*DSSPYVRAHRDCGLCPGVVCGPHGHCGG HCLHHPRPAFSWCFQTPRAIVSASPSTGAEEWTC *MT*HYSLARFIISLFSSKYFSSHLFSGT*AAI SPQSSQMPLHSFPDLLIFFFFSQMLPTKTCLG* ATRLPNSSVTSI*NLQGSNKFLL*DLCQIFPSFI QG*LKLWLIIGVLLCFNPI*PHFPDHFSCPVTQ KPPSTV*PDNMLIS*LTLIFLASLCSHPWHCHP PLNSGNNEINGYRLPLAQNCYSKNFRTKK*VCTN FNVAFKSMTEK*VRIKEI*ISKISKVKMYSQNF KFMKNDDSRSLPLPLSP*DKNSLGRKRNGSQKN IRIRQ*CGCLKRNKYLFLT*G**QWEKGRE*KPQ TYLGALNRGAVCLTS*MKLY*ITM*LSLCHSGM KETV**IWLQDVSWKHANIFRNPQPFPLTPPD* GKHELMRETLGRTTQLRQCSSSSGCCVLHWIRHL RGETLTEEMGQQRPHGSKQL*NP*GYF*PCYLH Q*V*ILIGEKIQNINAIIDTV*FGAKNPKSKSR TQYFEASILNFINV*SL*HFWPYFSHPQCRSNNT FLAELLIKFE*F*YLVNALHIVHEHIRKHCGYI YN*FI*KNGSYYMKSTFVFLSLLMI*EIQM*SY G*ISFHMIIEGYFSFSRMREAEIGLVRELLALEV VIFDFGFQLSKREYIPSLWPISVYSRYIIYNRS LCLFTLGKK*R*FKEKII*NTDWESVSTGNLNQ **S*KCPSQSTDDFQGNKTILFDTTMVKNVIIHL LKSTEYITPRVRLNVNYGLWVIMMCQCKFINYS KCTTQMGDVANGGGYACVGAECIWQQSPAFLAA GTSFMEDNFSTDSWGNGGMIWG*NCETIPPQINK H*LDSHKEHAT*ISCMHS*K*GSHSYENLMPPL I*RKAGLSW*CWLTHCVVQFLTGHQLVLVHGPG VGDLWDTSAPSAQFFCEPTTALK*GLFLKRKREG NQL*S*MCKIKILV*KTVTLKCTTC*EAFSNRV SNIFHIHFNDS*GKNPAFWSCVHLCVCVCVCVC VCNIRGILNGIMTRVMQKSTNAAQLRLLPQAALW KANLMIAVFY*KDVFKKYLRNVKIAELKLILKN KSK*FFLSAKNVGPTINRVTDLPA*FKIMQFLN NYLSYLNYFRLHT*SVTSLILNITLFKIYKISGS QRLVLVILALWRPIGEDCLKPGVQQLPGQQSKT LSLQHKNKLMHGGTPVVPATLEAEARGVLEPRS SILQWAKIVPLCSLQPRQQSRTPSLKVNK*IKLT KF*KSNEICQVCTYHI*TRDLKN*TFYYK*STS CTDWHIVSSR*VLTICVIVIFWSPTNKSHSE*H HRDATNKIQNMETSTR*TTPFLQQQFKREREEKL YILKG*RNI*TKFV*GNQKN*HRLY*GII*F*C GNEIAVMFSKKSLYFRFS**NNYE*

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQWYASTILPLFT*VIPPYQGSLFSSQEVPRS SYGNC*NFIISHL*NHIFPCNTRVFPLCIQQIL LGEVSSTSYFIKHAHREKGTGIKQRQCVVAPKQ KVNKTSLTIRW*NAGRRALPGCNAELQGRAIHTS HQCCFLTTEVPEVTVFSKSPVTLGQPNTLICLV DNIFPPVVNITWLSNGQSVTEGVSETSFLSKSD HSFFKISYLTFLPSADEIYDCKVEHWGLDQPLLK HWEPEIPAPMSELTETVVCALGLSVGLMGIVVG TVFIIQGLRSVGASRHQGPL*VHRHLQEQKNGL AK*PSTILWPDLSYPFSPPNISPLTFSLGLKLLY PLRAHKCLYILSLTS*FFFSFLKCYLQRHAWGK PPGYLIPQ*PPSKISKEAINSFYEIYVKFFHLS SRAD*NYG**LGYSYVSIQFNLISQIIFHVQ*HR SHQVQYSLIIC*FLS*H*YFLLPCVPTLGTATH PSIQATMKLMDTVCPWPRIVIAKILEPKNKSVL ISMWLLKV*QRNKLG*RKFESQKYQK*KCILKTL NL*RMMTVEAFLFPCHLEIKIL*AGKEMEVRKT LE*DNNVGV*KGTNTYSSHRVSDNGKRDGSRSH RHI*EP*IEAQSASPPE*SCTR*PCSFPCATLA* RRQYSEYGYRMFLGNMPISSEIPSPFP*PLLTK ESMSL*EKP*EEQHS*DNVAAAVGAVSSTGFAI SEEKLSQRKWVSSDLMALNSYEIHEDISNHATCI SEFKF*LEKKYKTLMQ*LIQYSLVQRTLNPNPG LSTLKLVF*TL*MCEVSNISGLTFLIHNVGVII LSLQSY**NLNNFDI*SMPYT*YMNT*ENIVVIF IINLFKRMDHII*KALLFFSAS**FRRFKCRAM GEFLFI**LKDIFLFPE*ERLRLDW*ENS*H*K L*YLTLVFNSLRGNIFPPYGP*VFIQGISYTTDL YACLLWGRSEDSSRRK*FKTQTGNQ*AQEI*TS DDHENVHHRAQMIFRAIKLFCLIPQW*KMSLYI CSNPQNI*HQELDLM*TMDFG***CANVSS*IIA NVPLRWEMLLMGEAMHVWEQSVSGSSPQPFWQQ GPVLWKTIFPQIVGGMGV*SGDETVKLFHLRST SIS*ILIRNMQPRSLACTVKNRVRTPMRI*CHH* SDGRRGSVGNAGSPTAWSSF*QATNWYWSMARG LGTSGIPLHLLLSFSVNLQPL*NKVYF*KGKEK VTNYDPKCVK*KF*YEKQSH*NAQRAKKLLAIGF QIYFIYISMIREARTQHFGVVCICVCVCVCVCV SVI*GVY*MA**PESCRNLQMLPNSDSFLKQHC GKQI***QYFIKRMYSKNIYVMLK*QN*N*F*KI RVNSSFYQLKM*GLLSIGLQIYLPDLKSCNS*T II*AI*IISDYTHKV*LH*YLISHYLKFTKLVG HRGSCL*S*HFGGQ*GRIA*SQEFNSCLGNKARP CLYNTKIN*CMAALL*SQLL*RLRQEECLSPGV QYFSGLRLCHCAHSSLGSRAGLHL*K*INK*NL QNFKNQMKYVRFVPTTFKLGT*RIKHFITNEALH AQTGT**VVDRC*QFVLLLFSGVQLTNPTVNDI TGMQPTRSRIWKLLLDKQLHFFSNNSREREKRS YTF*KAEEIYEPNLYEAIRKTDTDCIKELSNFSV VMRLLLCFLKSHYTLDFHNKIIMNE