Sequences - Rnomics 📊 Palace

        ☰
    
        Rnomics 📊 Palace
    
                       Back to Rnomics Platform
            
                       Open Session

1 warning:

Access restricted to public data.
Please sign in at Rnomics Platform to access your data.

Navigation

Home

Sequences

Sequence HLA-DQA1.fAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTGGACAACATCTTTC CTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATCATTCCTTCTTCAA GATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGGTGCA TCGCCATCTACAGGAGCAGAAGAATGGACTTGCTAAATGACCTAGCACTATTCTCTGGCCCGATTTATCATATCCCTTTTCTCCTCCAAATATTTCTCCT CTCACCTTTTCTCTGGGACTTAAGCTGCTATATCCCCTCAGAGCTCACAAATGCCTTTACATTCTTTCCCTGACCTCCTGATTTTTTTTTTCTTTTCTCA AATGTTACCTACAAAGACATGCCTGGGGTAAGCCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTA TGAGATCTATGTCAAATTTTTCCATCTTTCATCCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATT TCCCAGATCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTC CTTGTGTTCCCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAA AATTTTAGAACCAAAAAATAAGTCTGTACTAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAA TATCAAAAGTAAAAATGTATTCTCAAAACTTTAAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTT AGGCAGGAAAAGAAATGGAAGTCAGAAAAACATTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGA CAATGGGAAAAGGGACGGGAGTAGAAGCCACAGACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAA CCATGTAGCTTTCCCTGTGCCACTCTGGCATGAAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCC CCAGCCCTTTCCCCTAACCCCTCCTGACTAAGGAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGT GGGTGCTGTGTCCTCCACTGGATTCGCCATCTCCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATC CATGAGGATATTTCTAACCATGCTACCTGCATCAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTT TGGTGCAAAGAACCCTAAATCCAAATCCAGGACTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTAC TTTTCTCATCCACAATGTAGGAGTAATAATACTTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTAC ATGAACACATAAGAAAACATTGTGGTTATATTTATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTT AATGATTTAGGAGATTCAAATGTAGAGCTATGGGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATT GGATTGGTAAGAGAACTCTTAGCACTAGAAGTTGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTG TTTATTCAAGGTATATCATATACAACAGATCTTTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTG GGAATCAGTAAGCACAGGAAATCTGAACCAGTGATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGAT ACCACAATGGTGAAAAATGTCATTATACATTTGCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAA TGATGTGCCAATGTAAGTTCATAAATTATAGCAAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTAT CTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAGGGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGA AACTGTGAAACTATTCCACCTCAGATCAACAAGCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTT CGCACTCCTATGAGAATCTAATGCCACCACTGATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGG CCACCAACTGGTACTGGTCCATGGCCCGGGGGTTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAA TAAGGTCTATTTTTAAAAAGGAAAAGAGAAGGTAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCA CAACGTGCTAAGAAGCTTTTAGCAATAGGGTTTCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCA TTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCC CAACTCAGACTCCTTCCTCAAGCAGCACTGTGGAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTA AAATAGCAGAATTAAAACTAATTCTAAAAAATAAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACC TGCCTGATTTAAAATCATGCAATTCTTAAACAATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATC ACACTATTTAAAATTTACAAAATTAGTGGGTCACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAG TTCAACAGCTGCCTGGGCAACAAAGCAAGACCTTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGC TGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTTCAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCA TCTCTAAAAGTAAATAAATAAATAAAACTTACAAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGA ATTAAACATTTTATTACAAATGAAGCACTTCATGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAG TCCAACTAACAAATCCCACAGTGAATGACATCACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAG CAACAATTCAAGAGAGAGAGAGAAGAGAAGCTATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACC GACTGTATTAAGGAATTATCTAATTTTAGTGTGGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTA TGAATGAAA

HLA-DQA1.F3 (forward primer)
HLA-DQA1.R3 (reverse primer)
Single exon skipping

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNEVPEVTVFSKSPVTLGQPNTLICLVDNIF PPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFK ISYLTFLPSADEIYDCKVEHWGLDQPLLKHWGA SPSTGAEEWTC*MT*HYSLARFIISLFSSKYFS SHLFSGT*AAISPQSSQMPLHSFPDLLIFFFFSQ MLPTKTCLG*ATRLPNSSVTSI*NLQGSNKFLL *DLCQIFPSFIQG*LKLWLIIGVLLCFNPI*PH FPDHFSCPVTQKPPSTV*PDNMLIS*LTLIFLAS LCSHPWHCHPPLNSGNNEINGYRLPLAQNCYSK NFRTKK*VCTNFNVAFKSMTEK*VRIKEI*ISK ISKVKMYSQNFKFMKNDDSRSLPLPLSP*DKNSL GRKRNGSQKNIRIRQ*CGCLKRNKYLFLT*G** QWEKGRE*KPQTYLGALNRGAVCLTS*MKLY*I TM*LSLCHSGMKETV**IWLQDVSWKHANIFRNP QPFPLTPPD*GKHELMRETLGRTTQLRQCSSSS GCCVLHWIRHLRGETLTEEMGQQRPHGSKQL*N P*GYF*PCYLHQ*V*ILIGEKIQNINAIIDTV*F GAKNPKSKSRTQYFEASILNFINV*SL*HFWPY FSHPQCRSNNTFLAELLIKFE*F*YLVNALHIV HEHIRKHCGYIYN*FI*KNGSYYMKSTFVFLSLL MI*EIQM*SYG*ISFHMIIEGYFSFSRMREAEI GLVRELLALEVVIFDFGFQLSKREYIPSLWPIS VYSRYIIYNRSLCLFTLGKK*R*FKEKII*NTDW ESVSTGNLNQ**S*KCPSQSTDDFQGNKTILFD TTMVKNVIIHLLKSTEYITPRVRLNVNYGLWVI MMCQCKFINYSKCTTQMGDVANGGGYACVGAECI WQQSPAFLAAGTSFMEDNFSTDSWGNGGMIWG* NCETIPPQINKH*LDSHKEHAT*ISCMHS*K*G SHSYENLMPPLI*RKAGLSW*CWLTHCVVQFLTG HQLVLVHGPGVGDLWDTSAPSAQFFCEPTTALK *GLFLKRKREGNQL*S*MCKIKILV*KTVTLKC TTC*EAFSNRVSNIFHIHFNDS*GKNPAFWSCVH LCVCVCVCVCVCNIRGILNGIMTRVMQKSTNAA QLRLLPQAALWKANLMIAVFY*KDVFKKYLRNV KIAELKLILKNKSK*FFLSAKNVGPTINRVTDLP A*FKIMQFLNNYLSYLNYFRLHT*SVTSLILNI TLFKIYKISGSQRLVLVILALWRPIGEDCLKPG VQQLPGQQSKTLSLQHKNKLMHGGTPVVPATLEA EARGVLEPRSSILQWAKIVPLCSLQPRQQSRTP SLKVNK*IKLTKF*KSNEICQVCTYHI*TRDLK N*TFYYK*STSCTDWHIVSSR*VLTICVIVIFWS PTNKSHSE*HHRDATNKIQNMETSTR*TTPFLQ QQFKREREEKLYILKG*RNI*TKFV*GNQKN*H RLY*GII*F*CGNEIAVMFSKKSLYFRFS**NNY E*

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMRFLRSQCFPSLP*HWVSPTPSFVLWTTSF LLWSTSHG*AMGSQSQKVFLRPASSPRVIIPSS RSVTSPSSLLLMRFMTARWSTGAWTSLF*NTGVH RHLQEQKNGLAK*PSTILWPDLSYPFSPPNISP LTFSLGLKLLYPLRAHKCLYILSLTS*FFFSFL KCYLQRHAWGKPPGYLIPQ*PPSKISKEAINSFY EIYVKFFHLSSRAD*NYG**LGYSYVSIQFNLI SQIIFHVQ*HRSHQVQYSLIIC*FLS*H*YFLL PCVPTLGTATHPSIQATMKLMDTVCPWPRIVIAK ILEPKNKSVLISMWLLKV*QRNKLG*RKFESQK YQK*KCILKTLNL*RMMTVEAFLFPCHLEIKIL *AGKEMEVRKTLE*DNNVGV*KGTNTYSSHRVSD NGKRDGSRSHRHI*EP*IEAQSASPPE*SCTR* PCSFPCATLA*RRQYSEYGYRMFLGNMPISSEI PSPFP*PLLTKESMSL*EKP*EEQHS*DNVAAAV GAVSSTGFAISEEKLSQRKWVSSDLMALNSYEI HEDISNHATCISEFKF*LEKKYKTLMQ*LIQYS LVQRTLNPNPGLSTLKLVF*TL*MCEVSNISGLT FLIHNVGVIILSLQSY**NLNNFDI*SMPYT*Y MNT*ENIVVIFIINLFKRMDHII*KALLFFSAS **FRRFKCRAMGEFLFI**LKDIFLFPE*ERLRL DW*ENS*H*KL*YLTLVFNSLRGNIFPPYGP*V FIQGISYTTDLYACLLWGRSEDSSRRK*FKTQT GNQ*AQEI*TSDDHENVHHRAQMIFRAIKLFCLI PQW*KMSLYICSNPQNI*HQELDLM*TMDFG** *CANVSS*IIANVPLRWEMLLMGEAMHVWEQSV SGSSPQPFWQQGPVLWKTIFPQIVGGMGV*SGDE TVKLFHLRSTSIS*ILIRNMQPRSLACTVKNRV RTPMRI*CHH*SDGRRGSVGNAGSPTAWSSF*Q ATNWYWSMARGLGTSGIPLHLLLSFSVNLQPL*N KVYF*KGKEKVTNYDPKCVK*KF*YEKQSH*NA QRAKKLLAIGFQIYFIYISMIREARTQHFGVVC ICVCVCVCVCVSVI*GVY*MA**PESCRNLQMLP NSDSFLKQHCGKQI***QYFIKRMYSKNIYVML K*QN*N*F*KIRVNSSFYQLKM*GLLSIGLQIY LPDLKSCNS*TII*AI*IISDYTHKV*LH*YLIS HYLKFTKLVGHRGSCL*S*HFGGQ*GRIA*SQE FNSCLGNKARPCLYNTKIN*CMAALL*SQLL*R LRQEECLSPGVQYFSGLRLCHCAHSSLGSRAGLH L*K*INK*NLQNFKNQMKYVRFVPTTFKLGT*R IKHFITNEALHAQTGT**VVDRC*QFVLLLFSG VQLTNPTVNDITGMQPTRSRIWKLLLDKQLHFFS NNSREREKRSYTF*KAEEIYEPNLYEAIRKTDT DCIKELSNFSVVMRLLLCFLKSHYTLDFHNKII MNE

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQ*GS*GHSVFQVSRDTGSAQHPHLSCGQHLS SCGQHHMAEQWAVSHRRCF*DQLPLQE*SFLLQ DQLPHLPPFC**DL*LQGGALGPGPASSETLGC IAIYRSRRMDLLNDLALFSGPIYHIPFLLQIFLL SPFLWDLSCYIPSELTNAFTFFP*PPDFFFLFS NVTYKDMPGVSHPAT*FLSNLHLKSPRKQ*IPF MRSMSNFSIFHPGLTETMANNWGTLMFQSNLTSF PRSFFMSSNTEATKYSIA**YVDFLADINISCF LVFPPLALPPTPQFRQQ*N*WIPSALGPELL*Q KF*NQKISLY*FQCGF*KYDREIS*DKGNLNLKN IKSKNVFSKL*IYEE**Q*KPSSSLVTLR*KFF RQEKKWKSEKH*NKTIMWVSEKEQILIPHIGLV TMGKGTGVEATDISRSPE*RRSLPHLLNEAVLDN HVAFPVPLWHEGDSIVNMATGCFLETCQYLQKS PALSPNPS*LRKA*AYERNPRKNNTVETM*QQQ WVLCPPLDSPSPRRNSHRGNGSAATSWL*TAMKS MRIFLTMLPASVSLNFNWRKNTKH*CNN*YSIV WCKEP*IQIQDSVL*S*YFKLYKCVKSLTFLAL LFSSTM*E**YFPCRVIDKI*IILIFSQCLTHST *THKKTLWLYL*LIYLKEWIILYEKHFCFSQPL NDLGDSNVELWVNFFSYDN*RIFFFFQNERG*D WIGKRTLSTRSCNI*LWFSTL*EGIYSLLMAHKC LFKVYHIQQIFMPVYFGEEVKIVQGENNLKHRL GISKHRKSEPVMIMKMSITEHR*FSGQ*NYSV* YHNGEKCHYTFAQIHRIYNTKS*T*CKLWTLGDN DVPM*VHKL*QMYHSDGRCC*WGRLCMCGSRVY LAAVPSLFGSRDQFYGRQFFHR*LGEWGYDLGM KL*NYSTSDQQALVRFS*GTCNLDLLHAQLKIGF ALL*ESNATTDLTEGGAQLVMLAHPLRGPVSNR PPTGTGPWPGGWGPLGYLCTFCSVFL*TYNRFK IRSIFKKEKRR*PIMILNV*NKNFSMKNSHIKMH NVLRSF*Q*GFKYISYTFQ*FVRQEPSILELCA FVCVCVCVCVCL*YKGYTEWHNDQSHAEIYKCC PTQTPSSSSTVESKFNDSSILLKGCIQKIFT*C* NSRIKTNSKK*E*IVLFIS*KCRAYYQ*GYRST CLI*NHAILKQLFELFELFQITHIKCDFINT*Y HTI*NLQN*WVTEARACDLSTLEANRGGLLEARS STAAWATKQDLVSTTQK*INAWRHSCSPSYSRG *GKRSA*AQEFNTSVG*DCATVLTPA*AAEQDS ISKSK*INKTYKILKIK*NMSGLYLPHLN*GLEE LNILLQMKHFMHRLAHSK*SIGVNNLCYCYFLE SN*QIPQ*MTSQGCNQQDPEYGNFY*INNSISS ATIQERERREAIHFKRLKKYMNQICMRQSEKLTP TVLRNYLILVW**DCCYVF*KVIIL*IFIIK*L *MK

Sequence HLA-DQA1.jAug05

GAAGATTCCAATTTAATGTCCTCCCTTTATTCATAGAACAATTCCTCAAGTCCACTCTGAGTAGAGGCTGCATCACAAGGGGATTGCCCCGTCTCCTTCC AGGGCTCTTAATACAAACTCTTCAACTAGTAACTGAGATGTCACCATAGGGGATTTTTCTAATTGGCCAAAACCTGACTTGGCAGGGTTTGGTTTGGGTG TCTTCAGATTTCCTTGTCTTGAGGTCCTCACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCCTAAACAAAGCT CTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAGGTGAAGACATTGTGGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACC AGTTTTACGGTCCCTCTGGCCAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAGACTGCCTGGCGGTGGCCTGA GTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTGAGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGGTATGCGTCCACCATTCTGCCTCTCTTTACTTAAGTTATCCCTCCATACCAGGGTTCATTATTTTCTTCCCAAGAGGTCCCCAGATC TTCTTATGGCAATTGCTGAAATTTTATCATCTCCCATCTCTAAAATCACATATTCCCATGTAATACAAGGGTCTTTCCATTATGCATTCAGCAAATCCTT CTAGGAGAGGTCTCATCAACCTCCTACTTTATTAAACATGCCCACAGAGAGAAGGGCACAGGAATAAAGCAGAGGCAATGTGTCGTTGCTCCCAAGCAGA AGGTAAATAAGACCTCTTTGACTATCAGGTGGTGAAATGCTGGTAGGAGGGCTCTTCCAGGATGTAATGCAGAACTTCAGGGCAGAGCTATTCACACTTC ACACCAGTGCTGTTTCCTCACCACAGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCAACACCCTCATTTGTCTTGTG GACAACATCTTTCCTCCTGTGGTCAACATCACATGGCTGAGCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATC ATTCCTTCTTCAAGATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACTGCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAA ACACTGGGAGCCTGAGATTCCAGCCCCTATGTCAGAGCTCACAGAGACTGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCATGGGCATTGTGGTGGGC ACTGTCTTCATCATCCAAGGCCTGCGTTCAGTTGGTGCTTCCAGACACCAAGGGCCATTGTGAGTGCATCGCCATCTACAGGAGCAGAAGAATGGACTTG CTAAATGACCTAGCACTATTCTCTGGCCCGATTTATCATATCCCTTTTCTCCTCCAAATATTTCTCCTCTCACCTTTTCTCTGGGACTTAAGCTGCTATA TCCCCTCAGAGCTCACAAATGCCTTTACATTCTTTCCCTGACCTCCTGATTTTTTTTTTCTTTTCTCAAATGTTACCTACAAAGACATGCCTGGGGTAAG CCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTAAAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATCTATGTCAAATTTTTCCATCTTTCAT CCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAATTTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAG AAGCCACCAAGTACAGTATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGTTCCCACCCTTGGCACTGCCACCCAC CCCTCAATTCAGGCAACAATGAAATTAATGGATACCGTCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTACTAA TTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTGAATCTCAAAAATATCAAAAGTAAAAATGTATTCTCAAAACTTT AAATTTATGAAGAATGATGACAGTAGAAGCCTTCCTCTTCCCTTGTCACCTTGAGATAAAAATTCTTTAGGCAGGAAAAGAAATGGAAGTCAGAAAAACA TTAGAATAAGACAATAATGTGGGTGTCTGAAAAGGAACAAATACTTATTCCTCACATAGGGTTAGTGACAATGGGAAAAGGGACGGGAGTAGAAGCCACA GACATATCTAGGAGCCCTGAATAGAGGCGCAGTCTGCCTCACCTCCTGAATGAAGCTGTACTAGATAACCATGTAGCTTTCCCTGTGCCACTCTGGCATG AAGGAGACAGTATAGTGAATATGGCTACAGGATGTTTCTTGGAAACATGCCAATATCTTCAGAAATCCCCAGCCCTTTCCCCTAACCCCTCCTGACTAAG GAAAGCATGAGCTTATGAGAGAAACCCTAGGAAGAACAACACAGTTGAGACAATGTAGCAGCAGCAGTGGGTGCTGTGTCCTCCACTGGATTCGCCATCT CCGAGGAGAAACTCTCACAGAGGAAATGGGTCAGCAGCGACCTCATGGCTCTAAACAGCTATGAAATCCATGAGGATATTTCTAACCATGCTACCTGCAT CAGTGAGTTTAAATTTTAATTGGAGAAAAAATACAAAACATTAATGCAATAATTGATACAGTATAGTTTGGTGCAAAGAACCCTAAATCCAAATCCAGGA CTCAGTACTTTGAAGCTAGTATTTTAAACTTTATAAATGTGTGAAGTCTCTAACATTTCTGGCCTTACTTTTCTCATCCACAATGTAGGAGTAATAATAC TTTCCTTGCAGAGTTATTGATAAAATTTGAATAATTTTGATATTTAGTCAATGCCTTACACATAGTACATGAACACATAAGAAAACATTGTGGTTATATT TATAATTAATTTATTTAAAAGAATGGATCATATTATATGAAAAGCACTTTTGTTTTTCTCAGCCTCTTAATGATTTAGGAGATTCAAATGTAGAGCTATG GGTGAATTTCTTTTCATATGATAATTGAAGGATATTTTTCTTTTTCCAGAATGAGAGAGGCTGAGATTGGATTGGTAAGAGAACTCTTAGCACTAGAAGT TGTAATATTTGACTTTGGTTTTCAACTCTCTAAGAGGGAATATATTCCCTCCTTATGGCCCATAAGTGTTTATTCAAGGTATATCATATACAACAGATCT TTATGCCTGTTTACTTTGGGGAAGAAGTGAAGATAGTTCAAGGAGAAAATAATTTAAAACACAGACTGGGAATCAGTAAGCACAGGAAATCTGAACCAGT GATGATCATGAAAATGTCCATCACAGAGCACAGATGATTTTCAGGGCAATAAAACTATTCTGTTTGATACCACAATGGTGAAAAATGTCATTATACATTT GCTCAAATCCACAGAATATATAACACCAAGAGTTAGACTTAATGTAAACTATGGACTTTGGGTGATAATGATGTGCCAATGTAAGTTCATAAATTATAGC AAATGTACCACTCAGATGGGAGATGTTGCTAATGGGGGAGGCTATGCATGTGTGGGAGCAGAGTGTATCTGGCAGCAGTCCCCAGCCTTTTTGGCAGCAG GGACCAGTTTTATGGAAGACAATTTTTCCACAGATAGTTGGGGGAATGGGGGTATGATCTGGGGATGAAACTGTGAAACTATTCCACCTCAGATCAACAA GCATTAGTTAGATTCTCATAAGGAACATGCAACCTAGATCTCTTGCATGCACAGTTAAAAATAGGGTTCGCACTCCTATGAGAATCTAATGCCACCACTG ATCTGACGGAAGGCGGGGCTCAGTTGGTAATGCTGGCTCACCCACTGCGTGGTCCAGTTTCTAACAGGCCACCAACTGGTACTGGTCCATGGCCCGGGGG TTGGGGACCTCTGGGATACCTCTGCACCTTCTGCTCAGTTTTTCTGTGAACCTACAACCGCTTTAAAATAAGGTCTATTTTTAAAAAGGAAAAGAGAAGG TAACCAATTATGATCCTAAATGTGTAAAATAAAAATTTTAGTATGAAAAACAGTCACATTAAAATGCACAACGTGCTAAGAAGCTTTTAGCAATAGGGTT TCAAATATATTTCATATACATTTCAATGATTCGTGAGGCAAGAACCCAGCATTTTGGAGTTGTGTGCATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TCTGTAATATAAGGGGTATACTGAATGGCATAATGACCAGAGTCATGCAGAAATCTACAAATGCTGCCCAACTCAGACTCCTTCCTCAAGCAGCACTGTG GAAAGCAAATTTAATGATAGCAGTATTTTATTAAAAGGATGTATTCAAAAAATATTTACGTAATGTTAAAATAGCAGAATTAAAACTAATTCTAAAAAAT AAGAGTAAATAGTTCTTTTTATCAGCTAAAAATGTAGGGCCTACTATCAATAGGGTTACAGATCTACCTGCCTGATTTAAAATCATGCAATTCTTAAACA ATTATTTGAGCTATTTGAATTATTTCAGATTACACACATAAAGTGTGACTTCATTAATACTTAATATCACACTATTTAAAATTTACAAAATTAGTGGGTC ACAGAGGCTCGTGCTTGTGATCTTAGCACTTTGGAGGCCAATAGGGGAGGATTGCTTGAAGCCAGGAGTTCAACAGCTGCCTGGGCAACAAAGCAAGACC TTGTCTCTACAACACAAAAATAAATTAATGCATGGCGGCACTCCTGTAGTCCCAGCTACTCTAGAGGCTGAGGCAAGAGGAGTGCTTGAGCCCAGGAGTT CAATACTTCAGTGGGCTAAGATTGTGCCACTGTGCTCACTCCAGCCTAGGCAGCAGAGCAGGACTCCATCTCTAAAAGTAAATAAATAAATAAAACTTAC AAAATTTTAAAAATCAAATGAAATATGTCAGGTTTGTACCTACCACATTTAAACTAGGGACTTGAAGAATTAAACATTTTATTACAAATGAAGCACTTCA TGCACAGACTGGCACATAGTAAGTAGTCGATAGGTGTTAACAATTTGTGTTATTGTTATTTTCTGGAGTCCAACTAACAAATCCCACAGTGAATGACATC ACAGGGATGCAACCAACAAGATCCAGAATATGGAAACTTCTACTAGATAAACAACTCCATTTCTTCAGCAACAATTCAAGAGAGAGAGAGAAGAGAAGCT ATACATTTTAAAAGGCTGAAGAAATATATGAACCAAATTTGTATGAGGCAATCAGAAAAACTGACACCGACTGTATTAAGGAATTATCTAATTTTAGTGT GGTAATGAGATTGCTGTTATGTTTTCTAAAAAGTCATTATACTTTAGATTTTCATAATAAAATAATTATGAATGAAA

HLA-DQA1.F3 (forward primer)
HLA-DQA1.R3 (reverse primer)
Single exon skipping

Frame 0

EDSNLMSSLYS*NNSSSPL*VEAASQGDCPVSF QGS*YKLFN**LRCHHRGFF*LAKT*LGRVWFGC LQISLS*GPHNYSTAQNTNC*GCLGKRMILNKA LLLGALALTTVMSPCGGEDIVADHVASCGVNLY QFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPE FSKFGGFDPQGALRNMAVAKHNLNIMIKRYNST AATNGMRPPFCLSLLKLSLHTRVHYFLPKRSPD LLMAIAEILSSPISKITYSHVIQGSFHYAFSKSF *ERSHQPPTLLNMPTERRAQE*SRGNVSLLPSR R*IRPL*LSGGEMLVGGLFQDVMQNFRAELFTL HTSAVSSPQRFLRSQCFPSLP*HWVSPTPSFVLW TTSFLLWSTSHG*AMGSQSQKVFLRPASSPRVI IPSSRSVTSPSSLLLMRFMTARWSTGAWTSLF* NTGSLRFQPLCQSSQRLWSVPWGCLWASWALWWA LSSSSKACVQLVLPDTKGHCECIAIYRSRRMDL LNDLALFSGPIYHIPFLLQIFLLSPFLWDLSCY IPSELTNAFTFFP*PPDFFFLFSNVTYKDMPGVS HPAT*FLSNLHLKSPRKQ*IPFMRSMSNFSIFH PGLTETMANNWGTLMFQSNLTSFPRSFFMSSNT EATKYSIA**YVDFLADINISCFLVFPPLALPPT PQFRQQ*N*WIPSALGPELL*QKF*NQKISLY* FQCGF*KYDREIS*DKGNLNLKNIKSKNVFSKL *IYEE**Q*KPSSSLVTLR*KFFRQEKKWKSEKH *NKTIMWVSEKEQILIPHIGLVTMGKGTGVEAT DISRSPE*RRSLPHLLNEAVLDNHVAFPVPLWH EGDSIVNMATGCFLETCQYLQKSPALSPNPS*LR KA*AYERNPRKNNTVETM*QQQWVLCPPLDSPS PRRNSHRGNGSAATSWL*TAMKSMRIFLTMLPA SVSLNFNWRKNTKH*CNN*YSIVWCKEP*IQIQD SVL*S*YFKLYKCVKSLTFLALLFSSTM*E**Y FPCRVIDKI*IILIFSQCLTHST*THKKTLWLY L*LIYLKEWIILYEKHFCFSQPLNDLGDSNVELW VNFFSYDN*RIFFFFQNERG*DWIGKRTLSTRS CNI*LWFSTL*EGIYSLLMAHKCLFKVYHIQQI FMPVYFGEEVKIVQGENNLKHRLGISKHRKSEPV MIMKMSITEHR*FSGQ*NYSV*YHNGEKCHYTF AQIHRIYNTKS*T*CKLWTLGDNDVPM*VHKL* QMYHSDGRCC*WGRLCMCGSRVYLAAVPSLFGSR DQFYGRQFFHR*LGEWGYDLGMKL*NYSTSDQQ ALVRFS*GTCNLDLLHAQLKIGFALL*ESNATT DLTEGGAQLVMLAHPLRGPVSNRPPTGTGPWPGG WGPLGYLCTFCSVFL*TYNRFKIRSIFKKEKRR *PIMILNV*NKNFSMKNSHIKMHNVLRSF*Q*G FKYISYTFQ*FVRQEPSILELCAFVCVCVCVCVC L*YKGYTEWHNDQSHAEIYKCCPTQTPSSSSTV ESKFNDSSILLKGCIQKIFT*C*NSRIKTNSKK *E*IVLFIS*KCRAYYQ*GYRSTCLI*NHAILKQ LFELFELFQITHIKCDFINT*YHTI*NLQN*WV TEARACDLSTLEANRGGLLEARSSTAAWATKQD LVSTTQK*INAWRHSCSPSYSRG*GKRSA*AQEF NTSVG*DCATVLTPA*AAEQDSISKSK*INKTY KILKIK*NMSGLYLPHLN*GLEELNILLQMKHF MHRLAHSK*SIGVNNLCYCYFLESN*QIPQ*MTS QGCNQQDPEYGNFY*INNSISSATIQERERREA IHFKRLKKYMNQICMRQSEKLTPTVLRNYLILV W**DCCYVF*KVIIL*IFIIK*L*MK

Frame 1

KIPI*CPPFIHRTIPQVHSE*RLHHKGIAPSPS RALNTNSSTSN*DVTIGDFSNWPKPDLAGFGLG VFRFPCLEVLTITLQLRTPTAEAALGRG*S*TKL CCWGPSL*PP**APVEVKTLWLTTLPLVV*TCT SFTVPLASTPMNLMEMSSSTWTWRGRRLPGGGL SSANLEVLTRRVH*ETWLWQNTT*TS*LNATTLP LLPMVCVHHSASLYLSYPSIPGFIIFFPRGPQI FLWQLLKFYHLPSLKSHIPM*YKGLSIMHSANP SRRGLINLLLY*TCPQREGHRNKAEAMCRCSQAE GK*DLFDYQVVKCW*EGSSRM*CRTSGQSYSHF TPVLFPHHRGS*GHSVFQVSRDTGSAQHPHLSC GQHLSSCGQHHMAEQWAVSHRRCF*DQLPLQE*S FLLQDQLPHLPPFC**DL*LQGGALGPGPASSE TLGA*DSSPYVRAHRDCGLCPGVVCGPHGHCGG HCLHHPRPAFSWCFQTPRAIVSASPSTGAEEWTC *MT*HYSLARFIISLFSSKYFSSHLFSGT*AAI SPQSSQMPLHSFPDLLIFFFFSQMLPTKTCLG* ATRLPNSSVTSI*NLQGSNKFLL*DLCQIFPSFI QG*LKLWLIIGVLLCFNPI*PHFPDHFSCPVTQ KPPSTV*PDNMLIS*LTLIFLASLCSHPWHCHP PLNSGNNEINGYRLPLAQNCYSKNFRTKK*VCTN FNVAFKSMTEK*VRIKEI*ISKISKVKMYSQNF KFMKNDDSRSLPLPLSP*DKNSLGRKRNGSQKN IRIRQ*CGCLKRNKYLFLT*G**QWEKGRE*KPQ TYLGALNRGAVCLTS*MKLY*ITM*LSLCHSGM KETV**IWLQDVSWKHANIFRNPQPFPLTPPD* GKHELMRETLGRTTQLRQCSSSSGCCVLHWIRHL RGETLTEEMGQQRPHGSKQL*NP*GYF*PCYLH Q*V*ILIGEKIQNINAIIDTV*FGAKNPKSKSR TQYFEASILNFINV*SL*HFWPYFSHPQCRSNNT FLAELLIKFE*F*YLVNALHIVHEHIRKHCGYI YN*FI*KNGSYYMKSTFVFLSLLMI*EIQM*SY G*ISFHMIIEGYFSFSRMREAEIGLVRELLALEV VIFDFGFQLSKREYIPSLWPISVYSRYIIYNRS LCLFTLGKK*R*FKEKII*NTDWESVSTGNLNQ **S*KCPSQSTDDFQGNKTILFDTTMVKNVIIHL LKSTEYITPRVRLNVNYGLWVIMMCQCKFINYS KCTTQMGDVANGGGYACVGAECIWQQSPAFLAA GTSFMEDNFSTDSWGNGGMIWG*NCETIPPQINK H*LDSHKEHAT*ISCMHS*K*GSHSYENLMPPL I*RKAGLSW*CWLTHCVVQFLTGHQLVLVHGPG VGDLWDTSAPSAQFFCEPTTALK*GLFLKRKREG NQL*S*MCKIKILV*KTVTLKCTTC*EAFSNRV SNIFHIHFNDS*GKNPAFWSCVHLCVCVCVCVC VCNIRGILNGIMTRVMQKSTNAAQLRLLPQAALW KANLMIAVFY*KDVFKKYLRNVKIAELKLILKN KSK*FFLSAKNVGPTINRVTDLPA*FKIMQFLN NYLSYLNYFRLHT*SVTSLILNITLFKIYKISGS QRLVLVILALWRPIGEDCLKPGVQQLPGQQSKT LSLQHKNKLMHGGTPVVPATLEAEARGVLEPRS SILQWAKIVPLCSLQPRQQSRTPSLKVNK*IKLT KF*KSNEICQVCTYHI*TRDLKN*TFYYK*STS CTDWHIVSSR*VLTICVIVIFWSPTNKSHSE*H HRDATNKIQNMETSTR*TTPFLQQQFKREREEKL YILKG*RNI*TKFV*GNQKN*HRLY*GII*F*C GNEIAVMFSKKSLYFRFS**NNYE*

Frame 2

RFQFNVLPLFIEQFLKSTLSRGCITRGLPRLLP GLLIQTLQLVTEMSP*GIFLIGQNLTWQGLVWV SSDFLVLRSSQLLYSSEHQLLRLPWEEDDPKQS SAAGGPRSDHRDEPLWR*RHCG*PRCLLWCKLVP VLRSLWPVHP*I*WR*AVLRGPGEEGDCLAVA* VQQIWRF*PAGCTEKHGCGKTQLEHHD*TLQLY RCYQWYASTILPLFT*VIPPYQGSLFSSQEVPRS SYGNC*NFIISHL*NHIFPCNTRVFPLCIQQIL LGEVSSTSYFIKHAHREKGTGIKQRQCVVAPKQ KVNKTSLTIRW*NAGRRALPGCNAELQGRAIHTS HQCCFLTTEVPEVTVFSKSPVTLGQPNTLICLV DNIFPPVVNITWLSNGQSVTEGVSETSFLSKSD HSFFKISYLTFLPSADEIYDCKVEHWGLDQPLLK HWEPEIPAPMSELTETVVCALGLSVGLMGIVVG TVFIIQGLRSVGASRHQGPL*VHRHLQEQKNGL AK*PSTILWPDLSYPFSPPNISPLTFSLGLKLLY PLRAHKCLYILSLTS*FFFSFLKCYLQRHAWGK PPGYLIPQ*PPSKISKEAINSFYEIYVKFFHLS SRAD*NYG**LGYSYVSIQFNLISQIIFHVQ*HR SHQVQYSLIIC*FLS*H*YFLLPCVPTLGTATH PSIQATMKLMDTVCPWPRIVIAKILEPKNKSVL ISMWLLKV*QRNKLG*RKFESQKYQK*KCILKTL NL*RMMTVEAFLFPCHLEIKIL*AGKEMEVRKT LE*DNNVGV*KGTNTYSSHRVSDNGKRDGSRSH RHI*EP*IEAQSASPPE*SCTR*PCSFPCATLA* RRQYSEYGYRMFLGNMPISSEIPSPFP*PLLTK ESMSL*EKP*EEQHS*DNVAAAVGAVSSTGFAI SEEKLSQRKWVSSDLMALNSYEIHEDISNHATCI SEFKF*LEKKYKTLMQ*LIQYSLVQRTLNPNPG LSTLKLVF*TL*MCEVSNISGLTFLIHNVGVII LSLQSY**NLNNFDI*SMPYT*YMNT*ENIVVIF IINLFKRMDHII*KALLFFSAS**FRRFKCRAM GEFLFI**LKDIFLFPE*ERLRLDW*ENS*H*K L*YLTLVFNSLRGNIFPPYGP*VFIQGISYTTDL YACLLWGRSEDSSRRK*FKTQTGNQ*AQEI*TS DDHENVHHRAQMIFRAIKLFCLIPQW*KMSLYI CSNPQNI*HQELDLM*TMDFG***CANVSS*IIA NVPLRWEMLLMGEAMHVWEQSVSGSSPQPFWQQ GPVLWKTIFPQIVGGMGV*SGDETVKLFHLRST SIS*ILIRNMQPRSLACTVKNRVRTPMRI*CHH* SDGRRGSVGNAGSPTAWSSF*QATNWYWSMARG LGTSGIPLHLLLSFSVNLQPL*NKVYF*KGKEK VTNYDPKCVK*KF*YEKQSH*NAQRAKKLLAIGF QIYFIYISMIREARTQHFGVVCICVCVCVCVCV SVI*GVY*MA**PESCRNLQMLPNSDSFLKQHC GKQI***QYFIKRMYSKNIYVMLK*QN*N*F*KI RVNSSFYQLKM*GLLSIGLQIYLPDLKSCNS*T II*AI*IISDYTHKV*LH*YLISHYLKFTKLVG HRGSCL*S*HFGGQ*GRIA*SQEFNSCLGNKARP CLYNTKIN*CMAALL*SQLL*RLRQEECLSPGV QYFSGLRLCHCAHSSLGSRAGLHL*K*INK*NL QNFKNQMKYVRFVPTTFKLGT*RIKHFITNEALH AQTGT**VVDRC*QFVLLLFSGVQLTNPTVNDI TGMQPTRSRIWKLLLDKQLHFFSNNSREREKRS YTF*KAEEIYEPNLYEAIRKTDTDCIKELSNFSV VMRLLLCFLKSHYTLDFHNKIIMNE