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Sequences

Sequence ILK.gAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAAGTAAGGAACGGAGCCAACCCTGGGGAGGACCC
CCGGTCCCCTCTCCCAGAGTATACGGAGCCTGAACCTCCCCACTTCCCCCAACTCTGTTCGCGGATAGGGTCTAGTTGCCTGCTCTCGGACATCCGTTCA
GCAGACACTACCTCTTCGTCACCCCCTGCCCACCCTGACCCGCCTTTACCTCGCGTCTAGAGGACACAGCCAGGGATCATCCCGCAGCCCCGAACTCCTT
CACAGACCCCCACTAGCCGGGGACGCAGCTCAGGCCCCCTACCCCCAACACAAACACTTCTCTCCTGTAGAGGATAAAGCTTGGGGTTCATCCTCCTTCC
CTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGC
AGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGC
TCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACC
GTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGA
TCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAG
CTTCTCCGAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGTGAGTCACCACTGT
GGGAAGAAGGGTTGTAAAAGGAAATAATCCTGGCCTCTTGGGGCTGGGTTAGGGTGAAGCTGGGTACCTGACCTGCCCACACTCTTAGGAAATGGAACCC
TGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGGTGACCCCTGCCCTTCTTGCCCTTCC
CTCACTAAACCCCCATAAATTACTTGCTTTGTACCTGTTTTAAGTTTTTCCTCCAGTTAGTGGGCAAGGAAGTGGCAGCAACATTTCAAGCCTCCTAACC
CCTACCTGTCCTGCAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGAC
TTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCA
TCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACAT
GGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGATTGATGAGGACATGACTGCCCGA
ATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGCTCTGCAGAAGAAGCCTGAAGACA
CAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGG
AATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCG
GATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGG
AAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGA
CATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCT
CCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCC
CCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPK*GTEPTLGRT
PGPLSQSIRSLNLPTSPNSVRG*GLVACSRTSVQ
QTLPLRHPLPTLTRLYLASRGHSQGSSRSPELL
HRPPLAGDAAQAPYPQHKHFSPVEDKAWGSSSF
PGSLHSPQASPIQGTRRRDAAMDDIFTQCREGNA
VAVRLWLDNTENDLNQGDDHGFSPLHWACREGR
SAVVEMLIMRGARINVMNRGDDTPLHLAASHGH
RDIVQKLLQYKADINAVNEHGNVPLHYACFWGQD
QVAEDLVANGALVSICNKYGEMPVDKAKAPLRE
LLREKMGQNLNRIPYKDTFWKGTTRTRPRESPL
WEEGL*KEIILASWGWVRVKLGT*PAHTLRKWNP
EQTLWH*LQTA*LPDEAQRESLWRGDPCPSCPS
LTKPP*ITCFVPVLSFSSS*WARKWQQHFKPPN
PYLSCSYGRAAGRAMTLS*RC*RFETGVQGRAGT
SMKSVPGSGFSRIQMCSQC*VPASLHLLLILLS
SHTGCRMDPSTMYYMKAPISSWTRARL*SLLWT
WQGAWPSYTH*SPSSHDMHSIAVV**LMRT*LPE
LAWLMSSSLSNVLVACMHLPG*PPKLCRRSLKT
QTDAQQTCGVLQCFCGNW*HGRYPLLTSPIWRL
E*R*EHNSIHLCCGSGW*W*K*L*WALAPHIFVR
IYSNPVPRASGFSLHDRLKL*GCFFSCIRRWHW
KAFGLPSHQVFPLMCVSS*RSA*MKTLQSDPNL
T*LCLSLRRCRTSRTGRSLPELQRCRDMVGGMHL
PKAAGLWLPPPPPVMVLPQPWGPSPSPIPTTVA
PRGAGSELCHLPHGVSQHGRDQPRLSQ*SLL*K

Frame 1

ARVPVSARGPAPPVTPHFS*VPSKERSQPWGGP
PVPSPRVYGA*TSPLPPTLFADRV*LPALGHPF
SRHYLFVTPCPP*PAFTSRLEDTARDHPAAPNSF
TDPH*PGTQLRPPTPNTNTSLL*RIKLGVHPPS
LDHSTVLRLPQSRGLGAGTLLWTTFSLSAGRAT
QSPFACGWTTRRTTSTRGTIMASPPCTGPAERAA
LLWLRC*SCGGHGSM**TVGMTPPCIWQPVMDT
VILYRSYCSTRQTSMQ*MNTGMCPCTMPVFGAK
IKWQRTWWQMGPLSASVTSMERCLWTKPRHP*ES
FSERRWARISTVFHTRTHSGRGPPALGPVSHHC
GKKGCKRK*SWPLGAGLG*SWVPDLPTLLGNGT
LNKHSGIDFKQLNFLTKLNENHSGEVTPALLALP
SLNPHKLLALYLF*VFPPVSGQGSGSNISSLLT
PTCPAAMEGPLAGQ*HCREGAEGSRLEYKEEQG
LQ*RVSPAQDFLASKCAPSARCLPVSTCSSSYSH
HTLDAVWIPLQCTT*RHQFRRGPEPGCEVCFGH
GKGHGLPTHTRAPHPTTCTQ*P*CND**GHDCP
N*HG*CQVLFPMSWSHVCTCLGSPRSSAEEA*RH
KQTLSRHVEFCSASVGTGDTGGTLC*PLQYGDW
NEGESTTAYICVAGVVGDGENNCSGPWLLTYLF
GYTVILSQGPVASLYMTDSNCEAAFFLVFAGGIG
RPSAYHPTRYFPSCV*AHEDLHE*RPCKATQI*
HDCAYP*EDAGQVGLEGPCLNSRGVGTWLGECT
SPKQQASGCLPRLQSWYYPSHGVHPLPPSLPLWP
QEGRAQSFVTCHMVSPNMGGISPACHNKVYYEN

Frame 2

PESR*VREDPRPLSPLTSPESQVRNGANPGEDP
RSPLPEYTEPEPPHFPQLCSRIGSSCLLSDIRS
ADTTSSSPPAHPDPPLPRV*RTQPGIIPQPRTP
SQTPTSRGRSSGPLPPTQTLLSCRG*SLGFILLP
WITPQSSGFPNPGDSAPGRCYGRHFHSVPGGQR
SRRSPVAGQHGERPQPGGRSWLLPLALGLPRGP
LCCG*DVDHAGGTDQCNEPWG*HPPASGSQSWTP
*YCTEAIAVQGRHQCSE*TRECAPALCLFLGPR
SSGRGPGGKWGPCQHL*QVWRDACGQSQGTPER
ASPREDGPESQPYSIQGHILEGDHPHSAP*VTTV
GRRVVKGNNPGLLGLG*GEAGYLTCPHS*EMEP
*TNTLALTSNSLTS*RSSTRITLER*PLPFLPF
PH*TPINYLLCTCFKFFLQLVGKEVAATFQAS*P
LPVLQLWKGRWQGNDIVVKVLKVRDWSTRKSRD
FNEECPRLRIFSHPNVLPVLGACQSPPAPHPTL
ITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDM
ARGMAFLHTLEPLIPRHALNSRSVMIDEDMTAR
ISMADVKFSFQCPGRMYAPAWVAPEALQKKPED
TNRRSADMWSFAVLLWELVTREVPFADLSNMEIG
MKVRAQQHTFVLREWLVMVKITVVGLGSSHICS
DIQ*SCPKGQWLLST*QTQIVRLLFFLYSQVAL
EGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFD
MIVPILEKMQDK*DWKVLA*TPEVSGHGWGNAP
PQSSRPLVASPASSHGTTPAMGSIPFPHPYHCG
PKRGGLRALSLATWCLPTWEGSAPPVTIKFIMK

Sequence ILK.oAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGTCCTCAGG
CTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGA
CAACACGGAGAACGACCTCAACCAGGGTATCGTCTTGGATGCTTTGTGAAGAGCAGGTGGAAAGGAGGCAATTGCCTAGTTCATCGTAGAAGTAATGATG
TCTTGGACTAGAATTAGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATCATGCGGGGG
GCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGCAGTACAAGG
CAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGC
CCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAG
AATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCA
AACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGGTGACCCCTGCCCTTCTTGCCCTTCCCTCACTAAACCCCCATAAATTACTTGC
TTTGTACCTGTTTTAAGTTTTTCCTCCAGTTAGTGGGCAAGGAAGTGGCAGCAACATTTCAAGCCTCCTAACCCCTACCTGTCCTGCAGCTATGGAAGGG
CCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGG
TAGTGCAAGGCGTAACCTGGAAGCTGCTAGTTCCAAGGAACCCTGAATAGCACTGAAAGAGATCTTTTGTACTGGGTCTCAACCACTCCCTCCCTCTTCT
AGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGAT
CCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTGACTT
TTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTC
ATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTTACCT
CCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTA
TGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACA
GGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTG
CTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGC
GGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCT
CTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCT
CATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGT
AGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTC
CAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACA
TGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRPQ
ASPIQGTRRRDAAMDDIFTQCREGNAVAVRLWLD
NTENDLNQGIVLDAL*RAGGKEAIA*FIVEVMM
SWTRIRGRSWLLPLALGLPRGPLCCG*DVDHAG
GTDQCNEPWG*HPPASGSQSWTP*YCTEAIAVQG
RHQCSE*TRECAPALCLFLGPRSSGRGPGGKWG
PCQHL*QVWRDACGQSQGTPERASPRAGREDGP
ESQPYSIQGHILEGDHPHSAPKWNPEQTLWH*LQ
TA*LPDEAQRESLWRGDPCPSCPSLTKPP*ITC
FVPVLSFSSS*WARKWQQHFKPPNPYLSCSYGR
AAGRAMTLS*RC*RFETGVQGRAGTSMKSVPGSG
SARRNLEAASSKEP*IALKEIFCTGSQPLPPSS
RIFSHPNVLPVLGACQSPPAPHPTLITHWMPYG
SLYNVLHEGTSE*GC*ISLGRKWQRGSLSELFDF
CLLSDFVVDQSQAVKFALDMARGMAFLHTLEPL
IPRHALNSRSVMVRPQAHSWPRPQKPFAYL*LT
SFYLFSLPQIDEDMTARISMADVKFSFQCPGRMY
APAWVAPEGE*SHHVGR*KRTTSEVVEGGRDRT
GKGARTDKPYLSSSAEEA*RHKQTLSRHVEFCS
ASVGTGDTGGTLC*PLQYGDWNEGESTTAYICVA
GVVGDGENNCSGPWLLTYLFGYTVILSQGPVAS
LYMTDSNCEAAFFLVFAGGIGRPSAYHPTRYFP
SCV*AHEDLHE*RPCKATQI*HDCAYP*EDAGQV
GLEGPCLNSRGVGTWLGECTSPKQQASGCLPRL
QSWYYPSHGVHPLPPSLPLWPQEGRAQSFVTCH
MVSPNMGGISPACHNKVYYEN

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPVLR
LPQSRGLGAGTLLWTTFSLSAGRATQSPFACGW
TTRRTTSTRVSSWMLCEEQVERRQLPSSS*K**C
LGLELGDDHGFSPLHWACREGRSAVVEMLIMRG
ARINVMNRGDDTPLHLAASHGHRDIVQKLLQYK
ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGA
LVSICNKYGEMPVDKAKAPLRELLRERAEKMGQ
NLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDF
KQLNFLTKLNENHSGEVTPALLALPSLNPHKLLA
LYLF*VFPPVSGQGSGSNISSLLTPTCPAAMEG
PLAGQ*HCREGAEGSRLEYKEEQGLQ*RVSPAQ
VVQGVTWKLLVPRNPE*H*KRSFVLGLNHSLPLL
GFSRIQMCSQC*VPASLHLLLILLSSHTGCRMD
PSTMYYMKAPVSRDVEFPWGGNGREGASLNYLT
FASSQISSWTRARL*SLLWTWQGAWPSYTH*SPS
SHDMHSIAVV*W*GHKLTPGPGPKSPLPIYDLP
PSICFLFLRLMRT*LPELAWLMSSSLSNVLVAC
MHLPG*PPKVSEVIMSGGKKGPPQK*WKGAETGQ
ARGPEQTSPISPALQKKPEDTNRRSADMWSFAV
LLWELVTREVPFADLSNMEIGMKVRAQQHTFVL
REWLVMVKITVVGLGSSHICSDIQ*SCPKGQWLL
ST*QTQIVRLLFFLYSQVALEGLRPTIPPGISP
HVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
*DWKVLA*TPEVSGHGWGNAPPQSSRPLVASPAS
SHGTTPAMGSIPFPHPYHCGPKRGGLRALSLAT
WCLPTWEGSAPPVTIKFIMK

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPSSG
FPNPGDSAPGRCYGRHFHSVPGGQRSRRSPVAG
QHGERPQPGYRLGCFVKSRWKGGNCLVHRRSND
VLD*N*GTIMASPPCTGPAERAALLWLRC*SCGG
HGSM**TVGMTPPCIWQPVMDTVILYRSYCSTR
QTSMQ*MNTGMCPCTMPVFGAKIKWQRTWWQMG
PLSASVTSMERCLWTKPRHP*ESFSESGQRRWAR
ISTVFHTRTHSGRGPPALGPEMEP*TNTLALTS
NSLTS*RSSTRITLER*PLPFLPFPH*TPINYL
LCTCFKFFLQLVGKEVAATFQAS*PLPVLQLWKG
RWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLR
*CKA*PGSC*FQGTLNSTERDLLYWVSTTPSLF
*DFLASKCAPSARCLPVSTCSSSYSHHTLDAVWI
PLQCTT*RHQ*VGMLNFLGEEMAEREPL*TI*L
LPPLRFRRGPEPGCEVCFGHGKGHGLPTHTRAP
HPTTCTQ*P*CNGEATSSLLAQAPKALCLSMTYL
LLSVFSSSD**GHDCPN*HG*CQVLFPMSWSHV
CTCLGSPRR*VKSSCREVKKDHLRSSGRGQRQD
RQGGQNRQALSLQLCRRSLKTQTDAQQTCGVLQC
FCGNW*HGRYPLLTSPIWRLE*R*EHNSIHLCC
GSGW*W*K*L*WALAPHIFVRIYSNPVPRASGF
SLHDRLKL*GCFFSCIRRWHWKAFGLPSHQVFPL
MCVSS*RSA*MKTLQSDPNLT*LCLSLRRCRTS
RTGRSLPELQRCRDMVGGMHLPKAAGLWLPPPP
PVMVLPQPWGPSPSPIPTTVAPRGAGSELCHLPH
GVSQHGRDQPRLSQ*SLL*K

Sequence ILK.nAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGAGGATAAA
GCTTGGGGTTCATCCTCCTTCCCTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCA
CTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGCTATTGCAGTACAAGGCAGACATCAAT
GCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCA
TCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCG
TATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAAC
TTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGA
GTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGTAGTGCAAGGCGTAACCTGGAAGCTGCTAGTTCCAAGGAACCCTGAATAGCAC
TGAAAGAGATCTTTTGTACTGGGTCTCAACCACTCCCTCCCTCTTCTAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCC
ACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCC
TTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTGACTTTTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTT
TGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCA
CTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTTACCTCCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATT
AGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGT
AAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGC
CTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATAT
GGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACAT
ATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGG
TGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACC
CAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGG
AATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACC
ACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTAT
TATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRG*
SLGFILLPWITPQSSGFPNPGDSAPGRCYGRHFH
SVPGGQRSRRSPVAGQHGERPQPGLLQYKADIN
AVNEHGNVPLHYACFWGQDQVAEDLVANGALVS
ICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNR
IPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLN
FLTKLNENHSGELWKGRWQGNDIVVKVLKVRDW
STRKSRDFNEECPRLR*CKA*PGSC*FQGTLNST
ERDLLYWVSTTPSLF*DFLASKCAPSARCLPVS
TCSSSYSHHTLDAVWIPLQCTT*RHQ*VGMLNF
LGEEMAEREPL*TI*LLPPLRFRRGPEPGCEVCF
GHGKGHGLPTHTRAPHPTTCTQ*P*CNGEATSS
LLAQAPKALCLSMTYLLLSVFSSSD**GHDCPN
*HG*CQVLFPMSWSHVCTCLGSPRR*VKSSCREV
KKDHLRSSGRGQRQDRQGGQNRQALSLQLCRRS
LKTQTDAQQTCGVLQCFCGNW*HGRYPLLTSPI
WRLE*R*EHNSIHLCCGSGW*W*K*L*WALAPHI
FVRIYSNPVPRASGFSLHDRLKL*GCFFSCIRR
WHWKAFGLPSHQVFPLMCVSS*RSA*MKTLQSD
PNLT*LCLSLRRCRTSRTGRSLPELQRCRDMVGG
MHLPKAAGLWLPPPPPVMVLPQPWGPSPSPIPT
TVAPRGAGSELCHLPHGVSQHGRDQPRLSQ*SL
L*K

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPEDK
AWGSSSFPGSLHSPQASPIQGTRRRDAAMDDIF
TQCREGNAVAVRLWLDNTENDLNQGYCSTRQTSM
Q*MNTGMCPCTMPVFGAKIKWQRTWWQMGPLSA
SVTSMERCLWTKPRHP*ESFSESGQRRWARIST
VFHTRTHSGRGPPALGPEMEP*TNTLALTSNSLT
S*RSSTRITLESYGRAAGRAMTLS*RC*RFETG
VQGRAGTSMKSVPGSGSARRNLEAASSKEP*IA
LKEIFCTGSQPLPPSSRIFSHPNVLPVLGACQSP
PAPHPTLITHWMPYGSLYNVLHEGTSE*GC*IS
LGRKWQRGSLSELFDFCLLSDFVVDQSQAVKFA
LDMARGMAFLHTLEPLIPRHALNSRSVMVRPQAH
SWPRPQKPFAYL*LTSFYLFSLPQIDEDMTARI
SMADVKFSFQCPGRMYAPAWVAPEGE*SHHVGR
*KRTTSEVVEGGRDRTGKGARTDKPYLSSSAEEA
*RHKQTLSRHVEFCSASVGTGDTGGTLC*PLQY
GDWNEGESTTAYICVAGVVGDGENNCSGPWLLT
YLFGYTVILSQGPVASLYMTDSNCEAAFFLVFAG
GIGRPSAYHPTRYFPSCV*AHEDLHE*RPCKAT
QI*HDCAYP*EDAGQVGLEGPCLNSRGVGTWLG
ECTSPKQQASGCLPRLQSWYYPSHGVHPLPPSLP
LWPQEGRAQSFVTCHMVSPNMGGISPACHNKVY
YEN

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPRIK
LGVHPPSLDHSTVLRLPQSRGLGAGTLLWTTFS
LSAGRATQSPFACGWTTRRTTSTRAIAVQGRHQ
CSE*TRECAPALCLFLGPRSSGRGPGGKWGPCQH
L*QVWRDACGQSQGTPERASPRAGREDGPESQP
YSIQGHILEGDHPHSAPKWNPEQTLWH*LQTA*
LPDEAQRESLWRAMEGPLAGQ*HCREGAEGSRLE
YKEEQGLQ*RVSPAQVVQGVTWKLLVPRNPE*H
*KRSFVLGLNHSLPLLGFSRIQMCSQC*VPASL
HLLLILLSSHTGCRMDPSTMYYMKAPVSRDVEFP
WGGNGREGASLNYLTFASSQISSWTRARL*SLL
WTWQGAWPSYTH*SPSSHDMHSIAVV*W*GHKL
TPGPGPKSPLPIYDLPPSICFLFLRLMRT*LPEL
AWLMSSSLSNVLVACMHLPG*PPKVSEVIMSGG
KKGPPQK*WKGAETGQARGPEQTSPISPALQKK
PEDTNRRSADMWSFAVLLWELVTREVPFADLSNM
EIGMKVRAQQHTFVLREWLVMVKITVVGLGSSH
ICSDIQ*SCPKGQWLLST*QTQIVRLLFFLYSQ
VALEGLRPTIPPGISPHVCKLMKICMNEDPAKRP
KFDMIVPILEKMQDK*DWKVLA*TPEVSGHGWG
NAPPQSSRPLVASPASSHGTTPAMGSIPFPHPY
HCGPKRGGLRALSLATWCLPTWEGSAPPVTIKFI
MK

Sequence ILK.mAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGAGGATAAA
GCTTGGGGTTCATCCTCCTTCCCTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCA
CTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGTATCGTCTTGGATGCTTTGTGAAGAGC
AGGTGGAAAGGAGGCAATTGCCTAGTTCATCGTAGAAGTAATGATGTCTTGGACTAGAATTAGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTG
CCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCC
AGTCATGGACACCGTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTT
TTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGC
ACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACT
CGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGA
AGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCT
CAGGTAGTGCAAGGCGTAACCTGGAAGCTGCTAGTTCCAAGGAACCCTGAATAGCACTGAAAGAGATCTTTTGTACTGGGTCTCAACCACTCCCTCCCTC
TTCTAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTAT
GGATCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTG
ACTTTTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCC
CCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTT
ACCTCCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCA
TGTATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAG
GACAGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGC
AGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTG
TTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGC
TTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTC
CCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGAC
AAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCG
CCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGC
CACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRG*
SLGFILLPWITPQSSGFPNPGDSAPGRCYGRHFH
SVPGGQRSRRSPVAGQHGERPQPGYRLGCFVKS
RWKGGNCLVHRRSNDVLD*N*GTIMASPPCTGP
AERAALLWLRC*SCGGHGSM**TVGMTPPCIWQP
VMDTVILYRSYCSTRQTSMQ*MNTGMCPCTMPV
FGAKIKWQRTWWQMGPLSASVTSMERCLWTKPR
HP*ESFSESGQRRWARISTVFHTRTHSGRGPPAL
GPEMEP*TNTLALTSNSLTS*RSSTRITLESYG
RAAGRAMTLS*RC*RFETGVQGRAGTSMKSVPG
SGSARRNLEAASSKEP*IALKEIFCTGSQPLPPS
SRIFSHPNVLPVLGACQSPPAPHPTLITHWMPY
GSLYNVLHEGTSE*GC*ISLGRKWQRGSLSELF
DFCLLSDFVVDQSQAVKFALDMARGMAFLHTLEP
LIPRHALNSRSVMVRPQAHSWPRPQKPFAYL*L
TSFYLFSLPQIDEDMTARISMADVKFSFQCPGR
MYAPAWVAPEGE*SHHVGR*KRTTSEVVEGGRDR
TGKGARTDKPYLSSSAEEA*RHKQTLSRHVEFC
SASVGTGDTGGTLC*PLQYGDWNEGESTTAYIC
VAGVVGDGENNCSGPWLLTYLFGYTVILSQGPVA
SLYMTDSNCEAAFFLVFAGGIGRPSAYHPTRYF
PSCV*AHEDLHE*RPCKATQI*HDCAYP*EDAG
QVGLEGPCLNSRGVGTWLGECTSPKQQASGCLPR
LQSWYYPSHGVHPLPPSLPLWPQEGRAQSFVTC
HMVSPNMGGISPACHNKVYYEN

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPEDK
AWGSSSFPGSLHSPQASPIQGTRRRDAAMDDIF
TQCREGNAVAVRLWLDNTENDLNQGIVLDAL*RA
GGKEAIA*FIVEVMMSWTRIRGRSWLLPLALGL
PRGPLCCG*DVDHAGGTDQCNEPWG*HPPASGS
QSWTP*YCTEAIAVQGRHQCSE*TRECAPALCLF
LGPRSSGRGPGGKWGPCQHL*QVWRDACGQSQG
TPERASPRAGREDGPESQPYSIQGHILEGDHPH
SAPKWNPEQTLWH*LQTA*LPDEAQRESLWRAME
GPLAGQ*HCREGAEGSRLEYKEEQGLQ*RVSPA
QVVQGVTWKLLVPRNPE*H*KRSFVLGLNHSLP
LLGFSRIQMCSQC*VPASLHLLLILLSSHTGCRM
DPSTMYYMKAPVSRDVEFPWGGNGREGASLNYL
TFASSQISSWTRARL*SLLWTWQGAWPSYTH*S
PSSHDMHSIAVV*W*GHKLTPGPGPKSPLPIYDL
PPSICFLFLRLMRT*LPELAWLMSSSLSNVLVA
CMHLPG*PPKVSEVIMSGGKKGPPQK*WKGAET
GQARGPEQTSPISPALQKKPEDTNRRSADMWSFA
VLLWELVTREVPFADLSNMEIGMKVRAQQHTFV
LREWLVMVKITVVGLGSSHICSDIQ*SCPKGQW
LLST*QTQIVRLLFFLYSQVALEGLRPTIPPGIS
PHVCKLMKICMNEDPAKRPKFDMIVPILEKMQD
K*DWKVLA*TPEVSGHGWGNAPPQSSRPLVASP
ASSHGTTPAMGSIPFPHPYHCGPKRGGLRALSLA
TWCLPTWEGSAPPVTIKFIMK

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPRIK
LGVHPPSLDHSTVLRLPQSRGLGAGTLLWTTFS
LSAGRATQSPFACGWTTRRTTSTRVSSWMLCEE
QVERRQLPSSS*K**CLGLELGDDHGFSPLHWAC
REGRSAVVEMLIMRGARINVMNRGDDTPLHLAA
SHGHRDIVQKLLQYKADINAVNEHGNVPLHYAC
FWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA
PLRELLRERAEKMGQNLNRIPYKDTFWKGTTRT
RPRNGTLNKHSGIDFKQLNFLTKLNENHSGELW
KGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRL
R*CKA*PGSC*FQGTLNSTERDLLYWVSTTPSL
F*DFLASKCAPSARCLPVSTCSSSYSHHTLDAV
WIPLQCTT*RHQ*VGMLNFLGEEMAEREPL*TI*
LLPPLRFRRGPEPGCEVCFGHGKGHGLPTHTRA
PHPTTCTQ*P*CNGEATSSLLAQAPKALCLSMT
YLLLSVFSSSD**GHDCPN*HG*CQVLFPMSWSH
VCTCLGSPRR*VKSSCREVKKDHLRSSGRGQRQ
DRQGGQNRQALSLQLCRRSLKTQTDAQQTCGVL
QCFCGNW*HGRYPLLTSPIWRLE*R*EHNSIHLC
CGSGW*W*K*L*WALAPHIFVRIYSNPVPRASG
FSLHDRLKL*GCFFSCIRRWHWKAFGLPSHQVF
PLMCVSS*RSA*MKTLQSDPNLT*LCLSLRRCRT
SRTGRSLPELQRCRDMVGGMHLPKAAGLWLPPP
PPVMVLPQPWGPSPSPIPTTVAPRGAGSELCHL
PHGVSQHGRDQPRLSQ*SLL*K

Sequence ILK.lAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAAAGGATAAAGCTTGGGGTTCATCCTCCTTCCCT
GGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAG
TCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTC
TGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGT
GATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATC
AAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCT
TCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGTGAGTCA
CCACTGTGGGAAGAAGGGTTGTAAAAGGAAATAATCCTGGCCTCTTGGGGCTGGGTTAGGGTGAAGCTGGGTACCTGACCTGCCCACACTCTTAGGAAAT
GGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGGTGACCCCTGCCCTTCTTG
CCCTTCCCTCACTAAACCCCCATAAATTACTTGCTTTGTACCTGTTTTAAGTTTTTCCTCCAGTTAGTGGGCAAGGAAGTGGCAGCAACATTTCAAGCCT
CCTAACCCCTACCTGTCCTGCAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAG
CAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGTAGTGCAAGGCGTAACCTGGAAGCTGCTAGTTCCAAGGAACCCTGAATAGCACTGAAAGAGATCTT
TTGTACTGGGTCTCAACCACTCCCTCCCTCTTCTAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCAT
CCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAAT
GGCAGAGAGGGAGCCTCTCTGAACTATTTGACTTTTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAG
GGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGG
CCCCAAAAGCCCTTTGCCTATCTATGACTTACCTCCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATG
TCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCAC
CTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAA
CAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATG
AAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATA
TACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGG
CCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATG
ATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCC
AAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAA
GAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPKG*SLGFILLP
WITPQSSGFPNPGDSAPGRCYGRHFHSVPGGQRS
RRSPVAGQHGERPQPGGRSWLLPLALGLPRGPL
CCG*DVDHAGGTDQCNEPWG*HPPASGSQSWTP
*YCTEAIAVQGRHQCSE*TRECAPALCLFLGPRS
SGRGPGGKWGPCQHL*QVWRDACGQSQGTPERA
SPRAGREDGPESQPYSIQGHILEGDHPHSAP*V
TTVGRRVVKGNNPGLLGLG*GEAGYLTCPHS*EM
EP*TNTLALTSNSLTS*RSSTRITLER*PLPFL
PFPH*TPINYLLCTCFKFFLQLVGKEVAATFQA
S*PLPVLQLWKGRWQGNDIVVKVLKVRDWSTRKS
RDFNEECPRLR*CKA*PGSC*FQGTLNSTERDL
LYWVSTTPSLF*DFLASKCAPSARCLPVSTCSS
SYSHHTLDAVWIPLQCTT*RHQ*VGMLNFLGEEM
AEREPL*TI*LLPPLRFRRGPEPGCEVCFGHGK
GHGLPTHTRAPHPTTCTQ*P*CNGEATSSLLAQ
APKALCLSMTYLLLSVFSSSD**GHDCPN*HG*C
QVLFPMSWSHVCTCLGSPRR*VKSSCREVKKDH
LRSSGRGQRQDRQGGQNRQALSLQLCRRSLKTQ
TDAQQTCGVLQCFCGNW*HGRYPLLTSPIWRLE*
R*EHNSIHLCCGSGW*W*K*L*WALAPHIFVRI
YSNPVPRASGFSLHDRLKL*GCFFSCIRRWHWK
AFGLPSHQVFPLMCVSS*RSA*MKTLQSDPNLT*
LCLSLRRCRTSRTGRSLPELQRCRDMVGGMHLP
KAAGLWLPPPPPVMVLPQPWGPSPSPIPTTVAP
RGAGSELCHLPHGVSQHGRDQPRLSQ*SLL*K

Frame 1

ARVPVSARGPAPPVTPHFS*VPKDKAWGSSSFP
GSLHSPQASPIQGTRRRDAAMDDIFTQCREGNA
VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRS
AVVEMLIMRGARINVMNRGDDTPLHLAASHGHR
DIVQKLLQYKADINAVNEHGNVPLHYACFWGQD
QVAEDLVANGALVSICNKYGEMPVDKAKAPLREL
LRERAEKMGQNLNRIPYKDTFWKGTTRTRPRES
PLWEEGL*KEIILASWGWVRVKLGT*PAHTLRK
WNPEQTLWH*LQTA*LPDEAQRESLWRGDPCPSC
PSLTKPP*ITCFVPVLSFSSS*WARKWQQHFKP
PNPYLSCSYGRAAGRAMTLS*RC*RFETGVQGR
AGTSMKSVPGSGSARRNLEAASSKEP*IALKEIF
CTGSQPLPPSSRIFSHPNVLPVLGACQSPPAPH
PTLITHWMPYGSLYNVLHEGTSE*GC*ISLGRK
WQRGSLSELFDFCLLSDFVVDQSQAVKFALDMAR
GMAFLHTLEPLIPRHALNSRSVMVRPQAHSWPR
PQKPFAYL*LTSFYLFSLPQIDEDMTARISMAD
VKFSFQCPGRMYAPAWVAPEGE*SHHVGR*KRTT
SEVVEGGRDRTGKGARTDKPYLSSSAEEA*RHK
QTLSRHVEFCSASVGTGDTGGTLC*PLQYGDWN
EGESTTAYICVAGVVGDGENNCSGPWLLTYLFGY
TVILSQGPVASLYMTDSNCEAAFFLVFAGGIGR
PSAYHPTRYFPSCV*AHEDLHE*RPCKATQI*H
DCAYP*EDAGQVGLEGPCLNSRGVGTWLGECTSP
KQQASGCLPRLQSWYYPSHGVHPLPPSLPLWPQ
EGRAQSFVTCHMVSPNMGGISPACHNKVYYEN

Frame 2

PESR*VREDPRPLSPLTSPESQRIKLGVHPPSL
DHSTVLRLPQSRGLGAGTLLWTTFSLSAGRATQ
SPFACGWTTRRTTSTRGTIMASPPCTGPAERAA
LLWLRC*SCGGHGSM**TVGMTPPCIWQPVMDTV
ILYRSYCSTRQTSMQ*MNTGMCPCTMPVFGAKI
KWQRTWWQMGPLSASVTSMERCLWTKPRHP*ES
FSESGQRRWARISTVFHTRTHSGRGPPALGPVSH
HCGKKGCKRK*SWPLGAGLG*SWVPDLPTLLGN
GTLNKHSGIDFKQLNFLTKLNENHSGEVTPALL
ALPSLNPHKLLALYLF*VFPPVSGQGSGSNISSL
LTPTCPAAMEGPLAGQ*HCREGAEGSRLEYKEE
QGLQ*RVSPAQVVQGVTWKLLVPRNPE*H*KRS
FVLGLNHSLPLLGFSRIQMCSQC*VPASLHLLLI
LLSSHTGCRMDPSTMYYMKAPVSRDVEFPWGGN
GREGASLNYLTFASSQISSWTRARL*SLLWTWQ
GAWPSYTH*SPSSHDMHSIAVV*W*GHKLTPGPG
PKSPLPIYDLPPSICFLFLRLMRT*LPELAWLM
SSSLSNVLVACMHLPG*PPKVSEVIMSGGKKGP
PQK*WKGAETGQARGPEQTSPISPALQKKPEDTN
RRSADMWSFAVLLWELVTREVPFADLSNMEIGM
KVRAQQHTFVLREWLVMVKITVVGLGSSHICSD
IQ*SCPKGQWLLST*QTQIVRLLFFLYSQVALEG
LRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM
IVPILEKMQDK*DWKVLA*TPEVSGHGWGNAPP
QSSRPLVASPASSHGTTPAMGSIPFPHPYHCGPK
RGGLRALSLATWCLPTWEGSAPPVTIKFIMK

Sequence ILK.kAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAATCCTCAGGCTTCCCCAATCCAGGGGACTCGGC
GCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCA
GGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTA
ATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAG
TGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTG
TAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATT
CCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGTGAGTCACCACTGTGGGAAGAAGGGTTGTAAAAGGAAATAATCCTGGCCTCTT
GGGGCTGGGTTAGGGTGAAGCTGGGTACCTGACCTGCCCACACTCTTAGGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACT
TCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGGTGACCCCTGCCCTTCTTGCCCTTCCCTCACTAAACCCCCATAAATTACTTGCTTTGTACCTGTT
TTAAGTTTTTCCTCCAGTTAGTGGGCAAGGAAGTGGCAGCAACATTTCAAGCCTCCTAACCCCTACCTGTCCTGCAGCTATGGAAGGGCCGCTGGCAGGG
CAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCAT
CCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTAC
TACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTGACTTTTGCCTCCTCTCAGA
TTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCA
CTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTTACCTCCTTCTATCTGTTTT
CTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGT
AGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGA
ACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTG
GTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGA
TGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGAC
TCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTC
ATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCC
TTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTAC
CCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACA
TGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPNPQASPIQGTR
RRDAAMDDIFTQCREGNAVAVRLWLDNTENDLNQ
GDDHGFSPLHWACREGRSAVVEMLIMRGARINV
MNRGDDTPLHLAASHGHRDIVQKLLQYKADINA
VNEHGNVPLHYACFWGQDQVAEDLVANGALVSIC
NKYGEMPVDKAKAPLRELLRERAEKMGQNLNRI
PYKDTFWKGTTRTRPRESPLWEEGL*KEIILAS
WGWVRVKLGT*PAHTLRKWNPEQTLWH*LQTA*L
PDEAQRESLWRGDPCPSCPSLTKPP*ITCFVPV
LSFSSS*WARKWQQHFKPPNPYLSCSYGRAAGR
AMTLS*RC*RFETGVQGRAGTSMKSVPGSGFSRI
QMCSQC*VPASLHLLLILLSSHTGCRMDPSTMY
YMKAPVSRDVEFPWGGNGREGASLNYLTFASSQ
ISSWTRARL*SLLWTWQGAWPSYTH*SPSSHDMH
SIAVV*W*GHKLTPGPGPKSPLPIYDLPPSICF
LFLRLMRT*LPELAWLMSSSLSNVLVACMHLPG
*PPKVSEVIMSGGKKGPPQK*WKGAETGQARGPE
QTSPISPALQKKPEDTNRRSADMWSFAVLLWEL
VTREVPFADLSNMEIGMKVRAQQHTFVLREWLV
MVKITVVGLGSSHICSDIQ*SCPKGQWLLST*QT
QIVRLLFFLYSQVALEGLRPTIPPGISPHVCKL
MKICMNEDPAKRPKFDMIVPILEKMQDK*DWKV
LA*TPEVSGHGWGNAPPQSSRPLVASPASSHGTT
PAMGSIPFPHPYHCGPKRGGLRALSLATWCLPT
WEGSAPPVTIKFIMK

Frame 1

ARVPVSARGPAPPVTPHFS*VPILRLPQSRGLG
AGTLLWTTFSLSAGRATQSPFACGWTTRRTTST
RGTIMASPPCTGPAERAALLWLRC*SCGGHGSM*
*TVGMTPPCIWQPVMDTVILYRSYCSTRQTSMQ
*MNTGMCPCTMPVFGAKIKWQRTWWQMGPLSAS
VTSMERCLWTKPRHP*ESFSESGQRRWARISTVF
HTRTHSGRGPPALGPVSHHCGKKGCKRK*SWPL
GAGLG*SWVPDLPTLLGNGTLNKHSGIDFKQLN
FLTKLNENHSGEVTPALLALPSLNPHKLLALYLF
*VFPPVSGQGSGSNISSLLTPTCPAAMEGPLAG
Q*HCREGAEGSRLEYKEEQGLQ*RVSPAQDFLA
SKCAPSARCLPVSTCSSSYSHHTLDAVWIPLQCT
T*RHQ*VGMLNFLGEEMAEREPL*TI*LLPPLR
FRRGPEPGCEVCFGHGKGHGLPTHTRAPHPTTC
TQ*P*CNGEATSSLLAQAPKALCLSMTYLLLSVF
SSSD**GHDCPN*HG*CQVLFPMSWSHVCTCLG
SPRR*VKSSCREVKKDHLRSSGRGQRQDRQGGQ
NRQALSLQLCRRSLKTQTDAQQTCGVLQCFCGNW
*HGRYPLLTSPIWRLE*R*EHNSIHLCCGSGW*
W*K*L*WALAPHIFVRIYSNPVPRASGFSLHDR
LKL*GCFFSCIRRWHWKAFGLPSHQVFPLMCVSS
*RSA*MKTLQSDPNLT*LCLSLRRCRTSRTGRS
LPELQRCRDMVGGMHLPKAAGLWLPPPPPVMVL
PQPWGPSPSPIPTTVAPRGAGSELCHLPHGVSQH
GRDQPRLSQ*SLL*K

Frame 2

PESR*VREDPRPLSPLTSPESQSSGFPNPGDSA
PGRCYGRHFHSVPGGQRSRRSPVAGQHGERPQP
GGRSWLLPLALGLPRGPLCCG*DVDHAGGTDQC
NEPWG*HPPASGSQSWTP*YCTEAIAVQGRHQCS
E*TRECAPALCLFLGPRSSGRGPGGKWGPCQHL
*QVWRDACGQSQGTPERASPRAGREDGPESQPY
SIQGHILEGDHPHSAP*VTTVGRRVVKGNNPGLL
GLG*GEAGYLTCPHS*EMEP*TNTLALTSNSLT
S*RSSTRITLER*PLPFLPFPH*TPINYLLCTC
FKFFLQLVGKEVAATFQAS*PLPVLQLWKGRWQG
NDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH
PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNV
LHEGTSE*GC*ISLGRKWQRGSLSELFDFCLLSD
FVVDQSQAVKFALDMARGMAFLHTLEPLIPRHA
LNSRSVMVRPQAHSWPRPQKPFAYL*LTSFYLF
SLPQIDEDMTARISMADVKFSFQCPGRMYAPAWV
APEGE*SHHVGR*KRTTSEVVEGGRDRTGKGAR
TDKPYLSSSAEEA*RHKQTLSRHVEFCSASVGT
GDTGGTLC*PLQYGDWNEGESTTAYICVAGVVGD
GENNCSGPWLLTYLFGYTVILSQGPVASLYMTD
SNCEAAFFLVFAGGIGRPSAYHPTRYFPSCV*A
HEDLHE*RPCKATQI*HDCAYP*EDAGQVGLEGP
CLNSRGVGTWLGECTSPKQQASGCLPRLQSWYY
PSHGVHPLPPSLPLWPQEGRAQSFVTCHMVSPN
MGGISPACHNKVYYEN

Sequence ILK.iAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGGGGACTCG
GCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAAC
CAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATG
TAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGC
AGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATC
TGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTA
TTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTT
CCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGT
ACAAGGAAGAGCAGGGACTTCAATGAAGAGTGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTAC
TCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAATGGCAG
AGAGGGAGCCTCTCTGAACTATTTGACTTTTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCA
TGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGGCCCCA
AAAGCCCTTTGCCTATCTATGACTTACCTCCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAG
TTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAG
AAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGAC
GCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGT
GAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAG
TAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTC
GGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGT
GCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGC
AGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGG
GCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRGL
GAGTLLWTTFSLSAGRATQSPFACGWTTRRTTST
RGTIMASPPCTGPAERAALLWLRC*SCGGHGSM
**TVGMTPPCIWQPVMDTVILYRSYCSTRQTSM
Q*MNTGMCPCTMPVFGAKIKWQRTWWQMGPLSAS
VTSMERCLWTKPRHP*ESFSESGQRRWARISTV
FHTRTHSGRGPPALGPEMEP*TNTLALTSNSLT
S*RSSTRITLESYGRAAGRAMTLS*RC*RFETGV
QGRAGTSMKSDFLASKCAPSARCLPVSTCSSSY
SHHTLDAVWIPLQCTT*RHQ*VGMLNFLGEEMA
EREPL*TI*LLPPLRFRRGPEPGCEVCFGHGKGH
GLPTHTRAPHPTTCTQ*P*CNGEATSSLLAQAP
KALCLSMTYLLLSVFSSSD**GHDCPN*HG*CQ
VLFPMSWSHVCTCLGSPRR*VKSSCREVKKDHLR
SSGRGQRQDRQGGQNRQALSLQLCRRSLKTQTD
AQQTCGVLQCFCGNW*HGRYPLLTSPIWRLE*R
*EHNSIHLCCGSGW*W*K*L*WALAPHIFVRIYS
NPVPRASGFSLHDRLKL*GCFFSCIRRWHWKAF
GLPSHQVFPLMCVSS*RSA*MKTLQSDPNLT*L
CLSLRRCRTSRTGRSLPELQRCRDMVGGMHLPKA
AGLWLPPPPPVMVLPQPWGPSPSPIPTTVAPRG
AGSELCHLPHGVSQHGRDQPRLSQ*SLL*K

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPGDS
APGRCYGRHFHSVPGGQRSRRSPVAGQHGERPQ
PGGRSWLLPLALGLPRGPLCCG*DVDHAGGTDQC
NEPWG*HPPASGSQSWTP*YCTEAIAVQGRHQC
SE*TRECAPALCLFLGPRSSGRGPGGKWGPCQH
L*QVWRDACGQSQGTPERASPRAGREDGPESQPY
SIQGHILEGDHPHSAPKWNPEQTLWH*LQTA*L
PDEAQRESLWRAMEGPLAGQ*HCREGAEGSRLE
YKEEQGLQ*RVIFSHPNVLPVLGACQSPPAPHPT
LITHWMPYGSLYNVLHEGTSE*GC*ISLGRKWQ
RGSLSELFDFCLLSDFVVDQSQAVKFALDMARG
MAFLHTLEPLIPRHALNSRSVMVRPQAHSWPRPQ
KPFAYL*LTSFYLFSLPQIDEDMTARISMADVK
FSFQCPGRMYAPAWVAPEGE*SHHVGR*KRTTS
EVVEGGRDRTGKGARTDKPYLSSSAEEA*RHKQT
LSRHVEFCSASVGTGDTGGTLC*PLQYGDWNEG
ESTTAYICVAGVVGDGENNCSGPWLLTYLFGYT
VILSQGPVASLYMTDSNCEAAFFLVFAGGIGRPS
AYHPTRYFPSCV*AHEDLHE*RPCKATQI*HDC
AYP*EDAGQVGLEGPCLNSRGVGTWLGECTSPK
QQASGCLPRLQSWYYPSHGVHPLPPSLPLWPQEG
RAQSFVTCHMVSPNMGGISPACHNKVYYEN

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPGTR
RRDAAMDDIFTQCREGNAVAVRLWLDNTENDLN
QGDDHGFSPLHWACREGRSAVVEMLIMRGARIN
VMNRGDDTPLHLAASHGHRDIVQKLLQYKADINA
VNEHGNVPLHYACFWGQDQVAEDLVANGALVSI
CNKYGEMPVDKAKAPLRELLRERAEKMGQNLNR
IPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNF
LTKLNENHSGELWKGRWQGNDIVVKVLKVRDWS
TRKSRDFNEE*FSRIQMCSQC*VPASLHLLLIL
LSSHTGCRMDPSTMYYMKAPVSRDVEFPWGGNGR
EGASLNYLTFASSQISSWTRARL*SLLWTWQGA
WPSYTH*SPSSHDMHSIAVV*W*GHKLTPGPGP
KSPLPIYDLPPSICFLFLRLMRT*LPELAWLMSS
SLSNVLVACMHLPG*PPKVSEVIMSGGKKGPPQ
K*WKGAETGQARGPEQTSPISPALQKKPEDTNR
RSADMWSFAVLLWELVTREVPFADLSNMEIGMKV
RAQQHTFVLREWLVMVKITVVGLGSSHICSDIQ
*SCPKGQWLLST*QTQIVRLLFFLYSQVALEGL
RPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIV
PILEKMQDK*DWKVLA*TPEVSGHGWGNAPPQS
SRPLVASPASSHGTTPAMGSIPFPHPYHCGPKR
GGLRALSLATWCLPTWEGSAPPVTIKFIMK

Sequence ILK.hAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAATCCTCAGGCTTCCCCAATCCAGGGGACTCGGC
GCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCA
GGGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGG
ACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCG
GGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAA
CACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTG
TCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCT
CCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGC
ACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTGACTTTTGCCTCCTCTCAGATTTCGTCGTGG
ACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCG
TAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTTACCTCCTTCTATCTGTTTTCTCTTCCTCAG
ATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAG
GTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAGACAAGCC
CTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGA
GGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATA
ACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGA
GGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTG
CATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACT
CCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGG
GGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATC
AGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPNPQASPIQGTR
RRDAAMDDIFTQCREGNAVAVRLWLDNTENDLNQ
GYCSTRQTSMQ*MNTGMCPCTMPVFGAKIKWQR
TWWQMGPLSASVTSMERCLWTKPRHP*ESFSES
GQRRWARISTVFHTRTHSGRGPPALGPEMEP*TN
TLALTSNSLTS*RSSTRITLESYGRAAGRAMTL
S*RC*RFETGVQGRAGTSMKSVPGSGFSRIQMC
SQC*VPASLHLLLILLSSHTGCRMDPSTMYYMKA
PVSRDVEFPWGGNGREGASLNYLTFASSQISSW
TRARL*SLLWTWQGAWPSYTH*SPSSHDMHSIA
VV*W*GHKLTPGPGPKSPLPIYDLPPSICFLFLR
LMRT*LPELAWLMSSSLSNVLVACMHLPG*PPK
VSEVIMSGGKKGPPQK*WKGAETGQARGPEQTS
PISPALQKKPEDTNRRSADMWSFAVLLWELVTRE
VPFADLSNMEIGMKVRAQQHTFVLREWLVMVKI
TVVGLGSSHICSDIQ*SCPKGQWLLST*QTQIV
RLLFFLYSQVALEGLRPTIPPGISPHVCKLMKIC
MNEDPAKRPKFDMIVPILEKMQDK*DWKVLA*T
PEVSGHGWGNAPPQSSRPLVASPASSHGTTPAM
GSIPFPHPYHCGPKRGGLRALSLATWCLPTWEGS
APPVTIKFIMK

Frame 1

ARVPVSARGPAPPVTPHFS*VPILRLPQSRGLG
AGTLLWTTFSLSAGRATQSPFACGWTTRRTTST
RAIAVQGRHQCSE*TRECAPALCLFLGPRSSGRG
PGGKWGPCQHL*QVWRDACGQSQGTPERASPRA
GREDGPESQPYSIQGHILEGDHPHSAPKWNPEQ
TLWH*LQTA*LPDEAQRESLWRAMEGPLAGQ*HC
REGAEGSRLEYKEEQGLQ*RVSPAQDFLASKCA
PSARCLPVSTCSSSYSHHTLDAVWIPLQCTT*R
HQ*VGMLNFLGEEMAEREPL*TI*LLPPLRFRRG
PEPGCEVCFGHGKGHGLPTHTRAPHPTTCTQ*P
*CNGEATSSLLAQAPKALCLSMTYLLLSVFSSS
D**GHDCPN*HG*CQVLFPMSWSHVCTCLGSPRR
*VKSSCREVKKDHLRSSGRGQRQDRQGGQNRQA
LSLQLCRRSLKTQTDAQQTCGVLQCFCGNW*HG
RYPLLTSPIWRLE*R*EHNSIHLCCGSGW*W*K*
L*WALAPHIFVRIYSNPVPRASGFSLHDRLKL*
GCFFSCIRRWHWKAFGLPSHQVFPLMCVSS*RS
A*MKTLQSDPNLT*LCLSLRRCRTSRTGRSLPEL
QRCRDMVGGMHLPKAAGLWLPPPPPVMVLPQPW
GPSPSPIPTTVAPRGAGSELCHLPHGVSQHGRD
QPRLSQ*SLL*K

Frame 2

PESR*VREDPRPLSPLTSPESQSSGFPNPGDSA
PGRCYGRHFHSVPGGQRSRRSPVAGQHGERPQP
GLLQYKADINAVNEHGNVPLHYACFWGQDQVAE
DLVANGALVSICNKYGEMPVDKAKAPLRELLRER
AEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNK
HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDI
VVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVL
PVLGACQSPPAPHPTLITHWMPYGSLYNVLHEG
TSE*GC*ISLGRKWQRGSLSELFDFCLLSDFVV
DQSQAVKFALDMARGMAFLHTLEPLIPRHALNSR
SVMVRPQAHSWPRPQKPFAYL*LTSFYLFSLPQ
IDEDMTARISMADVKFSFQCPGRMYAPAWVAPE
GE*SHHVGR*KRTTSEVVEGGRDRTGKGARTDKP
YLSSSAEEA*RHKQTLSRHVEFCSASVGTGDTG
GTLC*PLQYGDWNEGESTTAYICVAGVVGDGEN
NCSGPWLLTYLFGYTVILSQGPVASLYMTDSNCE
AAFFLVFAGGIGRPSAYHPTRYFPSCV*AHEDL
HE*RPCKATQI*HDCAYP*EDAGQVGLEGPCLN
SRGVGTWLGECTSPKQQASGCLPRLQSWYYPSHG
VHPLPPSLPLWPQEGRAQSFVTCHMVSPNMGGI
SPACHNKVYYEN

Sequence ILK.fAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAAGTAAGGAACGGAGCCAACCCTGGGGAGGACCC
CCGGTCCCCTCTCCCAGAGTATACGGAGCCTGAACCTCCCCACTTCCCCCAACTCTGTTCGCGGATAGGGTCTAGTTGCCTGCTCTCGGACATCCGTTCA
GCAGACACTACCTCTTCGTCACCCCCTGCCCACCCTGACCCGCCTTTACCTCGCGTCTAGAGGACACAGCCAGGGATCATCCCGCAGCCCCGAACTCCTT
CACAGACCCCCACTAGCCGGGGACGCAGCTCAGGCCCCCTACCCCCAACACAAACACTTCTCTCCTGTAGAGGATAAAGCTTGGGGTTCATCCTCCTTCC
CTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGC
AGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGTGAGCTGAAACGGTTGGTGGATGAGAGGAAGGCTAGAGATCTCCTGGC
TACGTGGAGTGGAGTGCTCATGTCTGGTGGTGGCGGCTGCCTTTGCTAGCCAGTGTAATGAGTGCTAAGCATAGCCTGTGGGGGGCAGAGGGTTTTCACA
GAGGACGCAGTTTGAGCTGAATCTTGACTGCAGAATAAGAGTTTCACAGGCAGAGGCTACAGAGAGCTTTCCAGCCTCAGTAGACTGCATGGCCAAAGGC
TAGGGGGCAAGGCACAGAGCAGAGAGAACAGGAAATTGTCTGGAGTTCCATATGGCTGGAGGATAGATGATCTCTGTGGGTCGGAGCATTGGGTACAAGA
GGAAAAGAACAGGACATAAGACTGTAGAGGTCTCCAAGGATCAGCCAGATCATGCAAGCATATTTAGGCTATAAGAAGGTCTTTATTTTAAAAGCAAGGT
TTTAAAGCTGTATAGTGACATAATGAGATTGTCCATTTTTCAGTATCGTCTTGGATGCTTTGTGAAGAGCAGGTGGAAAGGAGGCAATTGCCTAGTTCAT
CGTAGAAGTAATGATGTCTTGGACTAGAATTAGGGTGAGTGAAAAAGAGAAGTGATCAAATTCCAGAAGTCTTTAGGACGAAGAATTGTGGAACTTGGTG
TGGGGAGTGAGTAAGGGCAAAGATGAGGACCAGGGTTCTGGCTTGGGAACTTGGTTGTTTTTACTGAGATGGAGAAAACTGGAGGATGAGGCATTTTATT
TTGGACATGTTAAAGTTAAGGTGACAATACAGCAAGGTGGAAATGTTGAGTGTGTTGTTGGTTATGCAGATTTGCAATTCAGGGGAGGAATCTGACTTGG
AGACACAGATTTGAGAGCTATCAGCATATAGATAGCATATATATATCATATATATAGATGATACTTGAAGACGTGGTTGTGAAGGAGAACGTCTCAGGAG
AGTGGAAGGCAAGAGGTCAGGGGACAGGAAGCCTGCACGACAGAAAAGGAGCAACCGCAAGTTGAAAAAGAAATAGGAAAATGTGTGAGTAAAGCTTACA
GAAGAGAATGTTTTAATGAAGGGGAGGTAGTCAACGGCAGTACAGGCTACTGAGAGATCAAAGAACATTAATATTTTAAAGTAGCCATTGAATTTACAGT
TGGGTTTTTTTTTTTTAAGTTAAGGGGTACATGTGCAGGTTTGTTGGATGGGTAAACTCAGGTCATGGAGGTTTGTTGTGCAGATCATTTCATCACCCAG
GTATTAAGCCGTGGCACCCATTAGTTATTTTTCCTGATCCCTCCCTCTTCCTACCCGCCCCACTCTGGTAGGCCCCAGTGTCTGTTGCTCCCCTCAGTGT
GCAGTTAGGATGTATTTGACCATCTGTGAGTGTTGTTTCAGAATAATGGGTGAAGAAATCAGACTACATTGGGTTCCTTAATTTAAGGCACTATGATGAA
CACCTTCTGTGCTGGGTGCTAGAGTCCAGAATCTGACATAATCTCTGCTCTCGATACAGCAGATTTGTGGCAGATTGAAAAGTAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCTGTCTCTA
CTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCGGAGGCTGAGGCAGGAGAACTGCTTGAACCCGGGAAGCAGAGG
CTGCAGTGAGCCAAGATCATGCCACTGCCCTCCAGCCTGGGCCACAGAGCAAGACTCTGTCTTAAAAAAGAAAAAGAAAACAAAAGTTGAGAGGTGAGCA
AATAGTGAAAGTGAATGTACACCAGTTCTACAAGGTTGGCTGAGATAGGAAGGCAAGAAGAGCAGTAGTGATGGTGACTCAGAGTGGCAAAATCAAATTC
TTTATTTTTTAAAATTGGTGGAGTTTAGTTTTTAGGTTTGACAGGTCAGGATCACCTGTCATCTTAGTCTAGACTTCACTGGTTCCCATTAGGTTCTACA
CTATTTCTCTTTAATACTTTGCAAAGTCATTTGTTCCATTTTTCATATAATTCTCAAAGGGTACCCTGATAAAGACAGTAAGCACTGTTACTGTTTTGTT
GGTGAGGAAATAGAGGCTTAGGCAGTTGCCCAGTGGGCCTAGCATCTAGGAAGACTCTAGCTGAGTCTAGGAAGACTCTAGGAAGATGCTGCCAGAAGGA
AAAGGGGTGGAATTAATGAAACTGGAAGGTTGTGGTGCTGGTTTGAGGAGTAAAGTATGGGGGCCAAAGTTGGCTATATGCTGGATATGAAGAGGGGGTT
AATTCCTTGCAGGTCTTCTTGAGATAGAAGTCCAGGCCCTGAGGTGGCAGGCAGCCTGATAGTGAACAGAACCCTTGTGCCCATACTTTTGCCCCCCGAG
TTTGGCCTGCCCTGGCGCCACAGGCAGTACTGGAAGCTGATAAGTCAGGGCACAAATTAAAGGTCTAGGAGGCAAGACCAACTGATAAACAGGGGGCGTA
ATGCTTCCTGGGGATAATCCCATCTCAAGGAAAAGCTTTTGGCTATTTCTGTGTTAGCAGATGCGAGCAAGTTGTGGAGGAAAATGATTAACTTAAAGGC
CACACCCCCCAACCCCTTCAGCTGTACGGGCATCTGGATGGCCAGACCCCTGATCAGCTCCAGGCCTTGCCTAGAGTCGCACACAGGAAGTGACCACAAC
ACTAAGGCATCCGGAGGCTGCTGGCCCAGACCACGGACCGCCCCCTGCTCCGCCCCTTGAATCTGCAGCCCCGAACTGGAGGGAATTTCCTTTTATGGCC
CCAGGCTGTCAGGCAGGCCCAGCTCCAAACCAATTGTTTTGTTTTGTTTGTATACTTTACTTTATAAAATACATATTTCTTGGAAAAGAAAAAAATCAGG
TATAGTTTTAATCCCAAAACAGCCATTCTCATTTTCTTCTGTTTTCTATGCACAGGATTGCTAAGTAGGGGAATCCTGCTTTGCATGGTGGTTTGTTATC
TACCTCATCAGTAGTCAAAAGCATTTCTCCTTTTCAACATAAACCCTTCCAAAACATCATTTAAATTCCATTCCATTTTTAGATGTTAGTTTCAGTACCA
GAGCCAAATAGTAAGTTTGTTCCCTCTTCTATAAGTTGTGGCCTGCCTTCTCCAAGACACCCTTCTCCCCCACTAACATGCACTGAACAGCTGCTGTCAA
TCCATTCCCTCAAGAAACTTAAAGGTCTAACAGACAAGACAGTCCATTAACAGATTTTTACAATCCAGTGCAACAAGTGCTGAAGTAGGGGGACATATAA
GATGTGGTGGAAAACAGAAAGGACCAATAGATGTTGCAGAAGGGGTGCAAGAGAAACCAGGGGAAGAGCACTACCACCTAAGGAAATGAGATGTGGGATA
TGGTGAAGATAACACATTTTTTTATAGAGGTTGTTGAGATATCTAGGTGGTTGGTTTGGTTTGAAGCTCAGGGGAAGGTCTGAAATGGACAGCTTTGGGA
GTTGCTGGCATGAATGAGAATCAAAGTCCTAGAGAGGTAAGCCTTCCCAGAGAGTATGTAATTATCAGTTTTTCAGGAATCAAAACCTTTGCCCCATCCC
ACCTCCAGCTCAATGACCATTGCCCCTTCCTCAAAGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAG
ATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGA
AGGTACGTACAAACTCCTTCGTCATCCACATCACATACATGCCATGAGGGTCAGTCACAGGCACTGTAACATACAGTAGAAAGCATGTGTGCTCTTCCCC
CTTTTCCCATGCCCTGACACCAGTATCTCATTTGGAACTGACTGTACTTTCTGCCTCTTCTTTTTGTCTGGCCATGGGGTCCAGCTATTGCAGTACAAGG
CAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGC
CCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAG
AATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCA
AACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGT
TCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGC
CAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAATTTCGTCGTGGACC
AGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAG
TGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCC
CCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAG
ACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGA
CACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGT
GAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAA
ATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGA
AGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGC
CTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCA
GCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGG
AGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPK*GTEPTLGRT
PGPLSQSIRSLNLPTSPNSVRG*GLVACSRTSVQ
QTLPLRHPLPTLTRLYLASRGHSQGSSRSPELL
HRPPLAGDAAQAPYPQHKHFSPVEDKAWGSSSF
PGSLHSPQASPIQGTRRRDAAMDDIFTQCREGNA
VAVRLWLDNTENDLNQG*AETVGG*EEG*RSPG
YVEWSAHVWWWRLPLLASVMSAKHSLWGAEGFH
RGRSLS*ILTAE*EFHRQRLQRAFQPQ*TAWPKA
RGQGTEQREQEIVWSSIWLEDR*SLWVGALGTR
GKEQDIRL*RSPRISQIMQAYLGYKKVFILKAR
F*SCIVT**DCPFFSIVLDAL*RAGGKEAIA*FI
VEVMMSWTRIRVSEKEK*SNSRSL*DEELWNLV
WGVSKGKDEDQGSGLGTWLFLLRWRKLEDEAFY
FGHVKVKVTIQQGGNVECVVGYADLQFRGGI*LG
DTDLRAISI*IAYIYHIYR*YLKTWL*RRTSQE
SGRQEVRGQEACTTEKEQPQVEKEIGKCVSKAY
RRECFNEGEVVNGSTGY*EIKEH*YFKVAIEFTV
GFFFFKLRGTCAGLLDG*TQVMEVCCADHFITQ
VLSRGTH*LFFLIPPSSYPPHSGRPQCLLLPSV
CS*DVFDHL*VLFQNNG*RNQTTLGSLI*GTMMN
TFCAGC*SPESDIISALDTADLWQIEK*AGRGG
SRL*SQHFGRPRLVDHEVRSSRPA*PTW*NPVS
TKNTKISQAWWRAPVIPATRRLRQENCLNPGSRG
CSEPRSCHCPPAWATEQDSVLKKKKKTKVER*A
NSESECTPVLQGWLR*EGKKSSSDGDSEWQNQI
LYFLKLVEFSF*V*QVRITCHLSLDFTGSH*VLH
YFSLILCKVICSIFHIILKGYPDKDSKHCYCFV
GEEIEA*AVAQWA*HLGRL*LSLGRL*EDAARR
KRGGINETGRLWCWFEE*SMGAKVGYMLDMKRGL
IPCRSS*DRSPGPEVAGSLIVNRTLVPILLPPE
FGLPWRHRQYWKLISQGTN*RSRRQDQLINRGR
NASWG*SHLKEKLLAISVLADASKLWRKMINLKA
TPPNPFSCTGIWMARPLISSRPCLESHTGSDHN
TKASGGCWPRPRTAPCSAP*ICSPELEGISFYG
PRLSGRPSSKPIVLFCLYTLLYKIHISWKRKKSG
IVLIPKQPFSFSSVFYAQDC*VGESCFAWWFVI
YLISSQKHFSFST*TLPKHHLNSIPFLDVSFST
RAK**VCSLFYKLWPAFSKTPFSPTNMH*TAAVN
PFPQET*RSNRQDSPLTDFYNPVQQVLK*GDI*
DVVENRKDQ*MLQKGCKRNQGKSTTT*GNEMWD
MVKITHFFIEVVEISRWLVWFEAQGKV*NGQLWE
LLA*MRIKVLER*AFPESM*LSVFQESKPLPHP
TSSSMTIAPSSKGRSWLLPLALGLPRGPLCCG*
DVDHAGGTDQCNEPWG*HPPASGSQSWTP*YCTE
GTYKLLRHPHHIHAMRVSHRHCNIQ*KACVLFP
LFPCPDTSISFGTDCTFCLFFLSGHGVQLLQYK
ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGA
LVSICNKYGEMPVDKAKAPLRELLRERAEKMGQ
NLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDF
KQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKV
RDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC
QSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVD
QSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS
VMIDEDMTARISMADVKFSFQCPGRMYAPAWVA
PEGE*SHHVGR*KRTTSEVVEGGRDRTGKGART
DKPYLSSSAEEA*RHKQTLSRHVEFCSASVGTGD
TGGTLC*PLQYGDWNEGESTTAYICVAGVVGDG
ENNCSGPWLLTYLFGYTVILSQGPVASLYMTDS
NCEAAFFLVFAGGIGRPSAYHPTRYFPSCV*AHE
DLHE*RPCKATQI*HDCAYP*EDAGQVGLEGPC
LNSRGVGTWLGECTSPKQQASGCLPRLQSWYYP
SHGVHPLPPSLPLWPQEGRAQSFVTCHMVSPNMG
GISPACHNKVYYEN

Frame 1

ARVPVSARGPAPPVTPHFS*VPSKERSQPWGGP
PVPSPRVYGA*TSPLPPTLFADRV*LPALGHPF
SRHYLFVTPCPP*PAFTSRLEDTARDHPAAPNSF
TDPH*PGTQLRPPTPNTNTSLL*RIKLGVHPPS
LDHSTVLRLPQSRGLGAGTLLWTTFSLSAGRAT
QSPFACGWTTRRTTSTRGELKRLVDERKARDLLA
TWSGVLMSGGGGCLC*PV**VLSIACGGQRVFT
EDAV*AES*LQNKSFTGRGYRELSSLSRLHGQR
LGGKAQSRENRKLSGVPYGWRIDDLCGSEHWVQE
EKNRT*DCRGLQGSARSCKHI*AIRRSLF*KQG
FKAV**HNEIVHFSVSSWMLCEEQVERRQLPSS
S*K**CLGLELG*VKKRSDQIPEVFRTKNCGTWC
GE*VRAKMRTRVLAWELGCFY*DGENWRMRHFI
LDMLKLR*QYSKVEMLSVLLVMQICNSGEESDL
ETQI*ELSAYR*HIYIIYIDDT*RRGCEGERLRR
VEGKRSGDRKPARQKRSNRKLKKK*ENV*VKLT
EENVLMKGR*STAVQATERSKNINILK*PLNLQ
LGFFFLS*GVHVQVCWMGKLRSWRFVVQIISSPR
Y*AVAPISYFS*SLPLPTRPTLVGPSVCCSPQC
AVRMYLTICECCFRIMGEEIRLHWVP*FKAL**
TPSVLGARVQNLT*SLLSIQQICGRLKSRPGAVA
HACNPSTLGGRGWWITRSGVRDQPDQHGETLSL
LKIQKLARRGGVRL*SQLLGG*GRRTA*TREAE
AAVSQDHATALQPGPQSKTLS*KRKRKQKLRGEQ
IVKVNVHQFYKVG*DRKARRAVVMVTQSGKIKF
FIF*NWWSLVFRFDRSGSPVILV*TSLVPIRFY
TISL*YFAKSFVPFFI*FSKGTLIKTVSTVTVLL
VRK*RLRQLPSGPSI*EDSS*V*EDSRKMLPEG
KGVELMKLEGCGAGLRSKVWGPKLAICWI*RGG
*FLAGLLEIEVQALRWQAA***TEPLCPYFCPPS
LACPGATGSTGS**VRAQIKGLGGKTN**TGGV
MLPGDNPISRKSFWLFLC*QMRASCGGK*LT*R
PHPPTPSAVRASGWPDP*SAPGLA*SRTQEVTTT
LRHPEAAGPDHGPPPAPPLESAAPNWREFPFMA
PGCQAGPAPNQLFCFVCILYFIKYIFLGKEKNQ
V*F*SQNSHSHFLLFSMHRIAK*GNPALHGGLLS
TSSVVKSISPFQHKPFQNII*IPFHF*MLVSVP
EPNSKFVPSSISCGLPSPRHPSPPLTCTEQLLS
IHSLKKLKGLTDKTVH*QIFTIQCNKC*SRGTYK
MWWKTERTNRCCRRGARETRGRALPPKEMRCGI
W*R*HIFL*RLLRYLGGWFGLKLRGRSEMDSFG
SCWHE*ESKS*RGKPSQRVCNYQFFRNQNLCPIP
PPAQ*PLPLPQRDDHGFSPLHWACREGRSAVVE
MLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ
KVRTNSFVIHITYMP*GSVTGTVTYSRKHVCSSP
FSHALTPVSHLELTVLSASSFCLAMGSSYCSTR
QTSMQ*MNTGMCPCTMPVFGAKIKWQRTWWQMG
PLSASVTSMERCLWTKPRHP*ESFSESGQRRWAR
ISTVFHTRTHSGRGPPALGPEMEP*TNTLALTS
NSLTS*RSSTRITLESYGRAAGRAMTLS*RC*R
FETGVQGRAGTSMKSVPGSGFSRIQMCSQC*VPA
SLHLLLILLSSHTGCRMDPSTMYYMKAPISSWT
RARL*SLLWTWQGAWPSYTH*SPSSHDMHSIAV
V**LMRT*LPELAWLMSSSLSNVLVACMHLPG*P
PKVSEVIMSGGKKGPPQK*WKGAETGQARGPEQ
TSPISPALQKKPEDTNRRSADMWSFAVLLWELV
TREVPFADLSNMEIGMKVRAQQHTFVLREWLVMV
KITVVGLGSSHICSDIQ*SCPKGQWLLST*QTQ
IVRLLFFLYSQVALEGLRPTIPPGISPHVCKLM
KICMNEDPAKRPKFDMIVPILEKMQDK*DWKVLA
*TPEVSGHGWGNAPPQSSRPLVASPASSHGTTP
AMGSIPFPHPYHCGPKRGGLRALSLATWCLPTW
EGSAPPVTIKFIMK

Frame 2

PESR*VREDPRPLSPLTSPESQVRNGANPGEDP
RSPLPEYTEPEPPHFPQLCSRIGSSCLLSDIRS
ADTTSSSPPAHPDPPLPRV*RTQPGIIPQPRTP
SQTPTSRGRSSGPLPPTQTLLSCRG*SLGFILLP
WITPQSSGFPNPGDSAPGRCYGRHFHSVPGGQR
SRRSPVAGQHGERPQPGVS*NGWWMRGRLEISW
LRGVECSCLVVAAAFASQCNEC*A*PVGGRGFSQ
RTQFELNLDCRIRVSQAEATESFPASVDCMAKG
*GARHRAERTGNCLEFHMAGG*MISVGRSIGYK
RKRTGHKTVEVSKDQPDHASIFRL*EGLYFKSKV
LKLYSDIMRLSIFQYRLGCFVKSRWKGGNCLVH
RRSNDVLD*N*GE*KREVIKFQKSLGRRIVELG
VGSE*GQR*GPGFWLGNLVVFTEMEKTGG*GILF
WTC*S*GDNTARWKC*VCCWLCRFAIQGRNLTW
RHRFESYQHIDSIYISYI*MILEDVVVKENVSG
EWKARGQGTGSLHDRKGATAS*KRNRKMCE*SLQ
KRMF**RGGSQRQYRLLRDQRTLIF*SSH*IYS
WVFFF*VKGYMCRFVGWVNSGHGGLLCRSFHHP
GIKPWHPLVIFPDPSLFLPAPLW*APVSVAPLSV
QLGCI*PSVSVVSE*WVKKSDYIGFLNLRHYDE
HLLCWVLESRI*HNLCSRYSRFVAD*KVGRARW
LTPVIPALWEAEAGGSRGQEFETSLTNMVKPCLY
*KYKN*PGVVACACNPSYSEAEAGELLEPGKQR
LQ*AKIMPLPSSLGHRARLCLKKEKENKS*EVS
K**K*MYTSSTRLAEIGRQEEQ**W*LRVAKSNS
LFFKIGGV*FLGLTGQDHLSS*SRLHWFPLGST
LFLFNTLQSHLFHFSYNSQRVP**RQ*ALLLFC
W*GNRGLGSCPVGLASRKTLAESRKTLGRCCQKE
KGWN**NWKVVVLV*GVKYGGQSWLYAGYEEGV
NSLQVFLR*KSRP*GGRQPDSEQNPCAHTFAPR
VWPALAPQAVLEADKSGHKLKV*EARPTDKQGA*
CFLGIIPSQGKAFGYFCVSRCEQVVEEND*LKG
HTPQPLQLYGHLDGQTPDQLQALPRVAHRK*PQ
H*GIRRLLAQTTDRPLLRPLNLQPRTGGNFLLWP
QAVRQAQLQTNCFVLFVYFTL*NTYFLEKKKIR
YSFNPKTAILIFFCFLCTGLLSRGILLCMVVCY
LPHQ*SKAFLLFNINPSKTSFKFHSIFRC*FQYQ
SQIVSLFPLL*VVACLLQDTLLPH*HALNSCCQ
SIPSRNLKV*QTRQSINRFLQSSATSAEVGGHI
RCGGKQKGPIDVAEGVQEKPGEEHYHLRK*DVGY
GEDNTFFYRGC*DI*VVGLV*SSGEGLKWTALG
VAGMNENQSPREVSLPREYVIISFSGIKTFAPS
HLQLNDHCPFLKGTIMASPPCTGPAERAALLWLR
C*SCGGHGSM**TVGMTPPCIWQPVMDTVILYR
RYVQTPSSSTSHTCHEGQSQAL*HTVESMCALP
PFPMP*HQYLIWN*LYFLPLLFVWPWGPAIAVQG
RHQCSE*TRECAPALCLFLGPRSSGRGPGGKWG
PCQHL*QVWRDACGQSQGTPERASPRAGREDGP
ESQPYSIQGHILEGDHPHSAPKWNPEQTLWH*LQ
TA*LPDEAQRESLWRAMEGPLAGQ*HCREGAEG
SRLEYKEEQGLQ*RVSPAQDFLASKCAPSARCL
PVSTCSSSYSHHTLDAVWIPLQCTT*RHQFRRGP
EPGCEVCFGHGKGHGLPTHTRAPHPTTCTQ*P*
CND**GHDCPN*HG*CQVLFPMSWSHVCTCLGS
PRR*VKSSCREVKKDHLRSSGRGQRQDRQGGQNR
QALSLQLCRRSLKTQTDAQQTCGVLQCFCGNW*
HGRYPLLTSPIWRLE*R*EHNSIHLCCGSGW*W
*K*L*WALAPHIFVRIYSNPVPRASGFSLHDRLK
L*GCFFSCIRRWHWKAFGLPSHQVFPLMCVSS*
RSA*MKTLQSDPNLT*LCLSLRRCRTSRTGRSL
PELQRCRDMVGGMHLPKAAGLWLPPPPPVMVLPQ
PWGPSPSPIPTTVAPRGAGSELCHLPHGVSQHG
RDQPRLSQ*SLL*K

Sequence ILK.dAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGTCCTCAGG
CTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGA
CAACACGGAGAACGACCTCAACCAGGGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTT
GGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACC
CCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGG
CCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGG
GCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAG
GATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCC
CTCTACAATGTACTACATGAAGGCACCAATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACA
CACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTC
TTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTA
GTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCA
GCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAG
CACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATC
CTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCT
ACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTA
TCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAG
GCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGG
CTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRPQ
ASPIQGTRRRDAAMDDIFTQCREGNAVAVRLWLD
NTENDLNQGYCSTRQTSMQ*MNTGMCPCTMPVF
GAKIKWQRTWWQMGPLSASVTSMERCLWTKPRH
P*ESFSESGQRRWARISTVFHTRTHSGRGPPALG
PEMEP*TNTLALTSNSLTS*RSSTRITLESYGR
AAGRAMTLS*RC*RFETGVQGRAGTSMKSVPGS
GFSRIQMCSQC*VPASLHLLLILLSSHTGCRMDP
STMYYMKAPISSWTRARL*SLLWTWQGAWPSYT
H*SPSSHDMHSIAVV**LMRT*LPELAWLMSSS
LSNVLVACMHLPG*PPKVSEVIMSGGKKGPPQK*
WKGAETGQARGPEQTSPISPALQKKPEDTNRRS
ADMWSFAVLLWELVTREVPFADLSNMEIGMKVR
AQQHTFVLREWLVMVKITVVGLGSSHICSDIQ*S
CPKGQWLLST*QTQIVRLLFFLYSQVALEGLRP
TIPPGISPHVCKLMKICMNEDPAKRPKFDMIVP
ILEKMQDK*DWKVLA*TPEVSGHGWGNAPPQSSR
PLVASPASSHGTTPAMGSIPFPHPYHCGPKRGG
LRALSLATWCLPTWEGSAPPVTIKFIMK

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPVLR
LPQSRGLGAGTLLWTTFSLSAGRATQSPFACGW
TTRRTTSTRAIAVQGRHQCSE*TRECAPALCLFL
GPRSSGRGPGGKWGPCQHL*QVWRDACGQSQGT
PERASPRAGREDGPESQPYSIQGHILEGDHPHS
APKWNPEQTLWH*LQTA*LPDEAQRESLWRAMEG
PLAGQ*HCREGAEGSRLEYKEEQGLQ*RVSPAQ
DFLASKCAPSARCLPVSTCSSSYSHHTLDAVWI
PLQCTT*RHQFRRGPEPGCEVCFGHGKGHGLPTH
TRAPHPTTCTQ*P*CND**GHDCPN*HG*CQVL
FPMSWSHVCTCLGSPRR*VKSSCREVKKDHLRS
SGRGQRQDRQGGQNRQALSLQLCRRSLKTQTDAQ
QTCGVLQCFCGNW*HGRYPLLTSPIWRLE*R*E
HNSIHLCCGSGW*W*K*L*WALAPHIFVRIYSN
PVPRASGFSLHDRLKL*GCFFSCIRRWHWKAFGL
PSHQVFPLMCVSS*RSA*MKTLQSDPNLT*LCL
SLRRCRTSRTGRSLPELQRCRDMVGGMHLPKAA
GLWLPPPPPVMVLPQPWGPSPSPIPTTVAPRGAG
SELCHLPHGVSQHGRDQPRLSQ*SLL*K

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPSSG
FPNPGDSAPGRCYGRHFHSVPGGQRSRRSPVAG
QHGERPQPGLLQYKADINAVNEHGNVPLHYACF
WGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP
LRELLRERAEKMGQNLNRIPYKDTFWKGTTRTR
PRNGTLNKHSGIDFKQLNFLTKLNENHSGELWK
GRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLR
IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGS
LYNVLHEGTNFVVDQSQAVKFALDMARGMAFLH
TLEPLIPRHALNSRSVMIDEDMTARISMADVKFS
FQCPGRMYAPAWVAPEGE*SHHVGR*KRTTSEV
VEGGRDRTGKGARTDKPYLSSSAEEA*RHKQTL
SRHVEFCSASVGTGDTGGTLC*PLQYGDWNEGES
TTAYICVAGVVGDGENNCSGPWLLTYLFGYTVI
LSQGPVASLYMTDSNCEAAFFLVFAGGIGRPSA
YHPTRYFPSCV*AHEDLHE*RPCKATQI*HDCAY
P*EDAGQVGLEGPCLNSRGVGTWLGECTSPKQQ
ASGCLPRLQSWYYPSHGVHPLPPSLPLWPQEGR
AQSFVTCHMVSPNMGGISPACHNKVYYEN

Sequence ILK.cAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGTCCTCAGG
CTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGA
CAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATC
ATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGC
AGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGC
AAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAG
ATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCA
TTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGT
GCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTA
GGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAATTTCG
TCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAA
TAGCCGTAGTGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCC
TGGGTAGCCCCCGAAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACAC
GGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGT
GTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGAC
TGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTC
ATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTG
TCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAACAGGCTG
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRPQ
ASPIQGTRRRDAAMDDIFTQCREGNAVAVRLWLD
NTENDLNQGDDHGFSPLHWACREGRSAVVEMLI
MRGARINVMNRGDDTPLHLAASHGHRDIVQKLL
QYKADINAVNEHGNVPLHYACFWGQDQVAEDLVA
NGALVSICNKYGEMPVDKAKAPLRELLRERAEK
MGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSG
IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKV
LKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVL
GACQSPPAPHPTLITHWMPYGSLYNVLHEGTNF
VVDQSQAVKFALDMARGMAFLHTLEPLIPRHALN
SRSVMIDEDMTARISMADVKFSFQCPGRMYAPA
WVAPEALQKKPEDTNRRSADMWSFAVLLWELVT
REVPFADLSNMEIGMKVALEGLRPTIPPGISPHV
CKLMKICMNEDPAKRPKFDMIVPILEKMQDK*D
WKVLA*TPEVSGHGWGNAPPQSSRPLVASPASS
HGTTPAMGSIPFPHPYHCGPKRGGLRALSLATWC
LPTWEGSAPPVTIKFIMKTG

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPVLR
LPQSRGLGAGTLLWTTFSLSAGRATQSPFACGW
TTRRTTSTRGTIMASPPCTGPAERAALLWLRC*S
CGGHGSM**TVGMTPPCIWQPVMDTVILYRSYC
STRQTSMQ*MNTGMCPCTMPVFGAKIKWQRTWW
QMGPLSASVTSMERCLWTKPRHP*ESFSESGQRR
WARISTVFHTRTHSGRGPPALGPEMEP*TNTLA
LTSNSLTS*RSSTRITLESYGRAAGRAMTLS*R
C*RFETGVQGRAGTSMKSVPGSGFSRIQMCSQC*
VPASLHLLLILLSSHTGCRMDPSTMYYMKAPIS
SWTRARL*SLLWTWQGAWPSYTH*SPSSHDMHS
IAVV**LMRT*LPELAWLMSSSLSNVLVACMHLP
G*PPKLCRRSLKTQTDAQQTCGVLQCFCGNW*H
GRYPLLTSPIWRLE*RWHWKAFGLPSHQVFPLM
CVSS*RSA*MKTLQSDPNLT*LCLSLRRCRTSRT
GRSLPELQRCRDMVGGMHLPKAAGLWLPPPPPV
MVLPQPWGPSPSPIPTTVAPRGAGSELCHLPHG
VSQHGRDQPRLSQ*SLL*KQA

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPSSG
FPNPGDSAPGRCYGRHFHSVPGGQRSRRSPVAG
QHGERPQPGGRSWLLPLALGLPRGPLCCG*DVD
HAGGTDQCNEPWG*HPPASGSQSWTP*YCTEAIA
VQGRHQCSE*TRECAPALCLFLGPRSSGRGPGG
KWGPCQHL*QVWRDACGQSQGTPERASPRAGRE
DGPESQPYSIQGHILEGDHPHSAPKWNPEQTLWH
*LQTA*LPDEAQRESLWRAMEGPLAGQ*HCREG
AEGSRLEYKEEQGLQ*RVSPAQDFLASKCAPSA
RCLPVSTCSSSYSHHTLDAVWIPLQCTT*RHQFR
RGPEPGCEVCFGHGKGHGLPTHTRAPHPTTCTQ
*P*CND**GHDCPN*HG*CQVLFPMSWSHVCTC
LGSPRSSAEEA*RHKQTLSRHVEFCSASVGTGDT
GGTLC*PLQYGDWNEGGIGRPSAYHPTRYFPSC
V*AHEDLHE*RPCKATQI*HDCAYP*EDAGQVG
LEGPCLNSRGVGTWLGECTSPKQQASGCLPRLQS
WYYPSHGVHPLPPSLPLWPQEGRAQSFVTCHMV
SPNMGGISPACHNKVYYENRL

Sequence ILK.bAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGAGGATAAA
GCTTGGGGTTCATCCTCCTTCCCTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCA
CTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCA
CTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCAT
CTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACT
ATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAA
AGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACC
ACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAG
AGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTG
TCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATG
CCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGG
CCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGA
TGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCA
GCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGGCAT
TGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATT
TGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCA
CCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTG
GCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAA
AACAGGCTG
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRG*
SLGFILLPWITPQSSGFPNPGDSAPGRCYGRHFH
SVPGGQRSRRSPVAGQHGERPQPGGRSWLLPLA
LGLPRGPLCCG*DVDHAGGTDQCNEPWG*HPPA
SGSQSWTP*YCTEAIAVQGRHQCSE*TRECAPAL
CLFLGPRSSGRGPGGKWGPCQHL*QVWRDACGQ
SQGTPERASPRAGREDGPESQPYSIQGHILEGD
HPHSAPKWNPEQTLWH*LQTA*LPDEAQRESLWR
AMEGPLAGQ*HCREGAEGSRLEYKEEQGLQ*RV
SPAQDFLASKCAPSARCLPVSTCSSSYSHHTLD
AVWIPLQCTT*RHQFRRGPEPGCEVCFGHGKGHG
LPTHTRAPHPTTCTQ*P*CND**GHDCPN*HG*
CQVLFPMSWSHVCTCLGSPRSSAEEA*RHKQTL
SRHVEFCSASVGTGDTGGTLC*PLQYGDWNEGGI
GRPSAYHPTRYFPSCV*AHEDLHE*RPCKATQI
*HDCAYP*EDAGQVGLEGPCLNSRGVGTWLGEC
TSPKQQASGCLPRLQSWYYPSHGVHPLPPSLPLW
PQEGRAQSFVTCHMVSPNMGGISPACHNKVYYE
NRL

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPEDK
AWGSSSFPGSLHSPQASPIQGTRRRDAAMDDIF
TQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLH
WACREGRSAVVEMLIMRGARINVMNRGDDTPLH
LAASHGHRDIVQKLLQYKADINAVNEHGNVPLH
YACFWGQDQVAEDLVANGALVSICNKYGEMPVDK
AKAPLRELLRERAEKMGQNLNRIPYKDTFWKGT
TRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSG
ELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEEC
PRLRIFSHPNVLPVLGACQSPPAPHPTLITHWM
PYGSLYNVLHEGTNFVVDQSQAVKFALDMARGM
AFLHTLEPLIPRHALNSRSVMIDEDMTARISMAD
VKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRS
ADMWSFAVLLWELVTREVPFADLSNMEIGMKVA
LEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKF
DMIVPILEKMQDK*DWKVLA*TPEVSGHGWGNA
PPQSSRPLVASPASSHGTTPAMGSIPFPHPYHC
GPKRGGLRALSLATWCLPTWEGSAPPVTIKFIMK
TG

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPRIK
LGVHPPSLDHSTVLRLPQSRGLGAGTLLWTTFS
LSAGRATQSPFACGWTTRRTTSTRGTIMASPPC
TGPAERAALLWLRC*SCGGHGSM**TVGMTPPCI
WQPVMDTVILYRSYCSTRQTSMQ*MNTGMCPCT
MPVFGAKIKWQRTWWQMGPLSASVTSMERCLWT
KPRHP*ESFSESGQRRWARISTVFHTRTHSGRGP
PALGPEMEP*TNTLALTSNSLTS*RSSTRITLE
SYGRAAGRAMTLS*RC*RFETGVQGRAGTSMKS
VPGSGFSRIQMCSQC*VPASLHLLLILLSSHTGC
RMDPSTMYYMKAPISSWTRARL*SLLWTWQGAW
PSYTH*SPSSHDMHSIAVV**LMRT*LPELAWL
MSSSLSNVLVACMHLPG*PPKLCRRSLKTQTDAQ
QTCGVLQCFCGNW*HGRYPLLTSPIWRLE*RWH
WKAFGLPSHQVFPLMCVSS*RSA*MKTLQSDPN
LT*LCLSLRRCRTSRTGRSLPELQRCRDMVGGMH
LPKAAGLWLPPPPPVMVLPQPWGPSPSPIPTTV
APRGAGSELCHLPHGVSQHGRDQPRLSQ*SLL*
KQA

Sequence ILK.aAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAAGTAAGGAACGGAGCCAACCCTGGGGAGGACCC
CCGGTCCCCTCTCCCAGAGTATACGGAGCCTGAACCTCCCCACTTCCCCCAACTCTGTTCGCGGATAGGGTCTAGTTGCCTGCTCTCGGACATCCGTTCA
GCAGACACTACCTCTTCGTCACCCCCTGCCCACCCTGACCCGCCTTTACCTCGCGTCTAGAGGACACAGCCAGGGATCATCCCGCAGCCCCGAACTCCTT
CACAGACCCCCACTAGCCGGGGACGCAGCTCAGGCCCCCTACCCCCAACACAAACACTTCTCTCCTGTAGAGGATAAAGCTTGGGGTTCATCCTCCTTCC
CTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGC
AGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGC
TCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACC
GTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGA
TCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAG
CTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATG
GAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCA
GGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCG
CATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATG
TACTACATGAAGGCACCAATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCC
CCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGT
CCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAG
TGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGGCATTGGAAGGCCTTCGGCCTACCAT
CCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTT
GAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTC
TGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAG
AGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAACAGGCTG
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPK*GTEPTLGRT
PGPLSQSIRSLNLPTSPNSVRG*GLVACSRTSVQ
QTLPLRHPLPTLTRLYLASRGHSQGSSRSPELL
HRPPLAGDAAQAPYPQHKHFSPVEDKAWGSSSF
PGSLHSPQASPIQGTRRRDAAMDDIFTQCREGNA
VAVRLWLDNTENDLNQGDDHGFSPLHWACREGR
SAVVEMLIMRGARINVMNRGDDTPLHLAASHGH
RDIVQKLLQYKADINAVNEHGNVPLHYACFWGQD
QVAEDLVANGALVSICNKYGEMPVDKAKAPLRE
LLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRN
GTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQ
GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFS
HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYN
VLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEP
LIPRHALNSRSVMIDEDMTARISMADVKFSFQC
PGRMYAPAWVAPEALQKKPEDTNRRSADMWSFA
VLLWELVTREVPFADLSNMEIGMKVALEGLRPTI
PPGISPHVCKLMKICMNEDPAKRPKFDMIVPIL
EKMQDK*DWKVLA*TPEVSGHGWGNAPPQSSRP
LVASPASSHGTTPAMGSIPFPHPYHCGPKRGGLR
ALSLATWCLPTWEGSAPPVTIKFIMKTG

Frame 1

ARVPVSARGPAPPVTPHFS*VPSKERSQPWGGP
PVPSPRVYGA*TSPLPPTLFADRV*LPALGHPF
SRHYLFVTPCPP*PAFTSRLEDTARDHPAAPNSF
TDPH*PGTQLRPPTPNTNTSLL*RIKLGVHPPS
LDHSTVLRLPQSRGLGAGTLLWTTFSLSAGRAT
QSPFACGWTTRRTTSTRGTIMASPPCTGPAERAA
LLWLRC*SCGGHGSM**TVGMTPPCIWQPVMDT
VILYRSYCSTRQTSMQ*MNTGMCPCTMPVFGAK
IKWQRTWWQMGPLSASVTSMERCLWTKPRHP*ES
FSESGQRRWARISTVFHTRTHSGRGPPALGPEM
EP*TNTLALTSNSLTS*RSSTRITLESYGRAAG
RAMTLS*RC*RFETGVQGRAGTSMKSVPGSGFSR
IQMCSQC*VPASLHLLLILLSSHTGCRMDPSTM
YYMKAPISSWTRARL*SLLWTWQGAWPSYTH*S
PSSHDMHSIAVV**LMRT*LPELAWLMSSSLSNV
LVACMHLPG*PPKLCRRSLKTQTDAQQTCGVLQ
CFCGNW*HGRYPLLTSPIWRLE*RWHWKAFGLP
SHQVFPLMCVSS*RSA*MKTLQSDPNLT*LCLSL
RRCRTSRTGRSLPELQRCRDMVGGMHLPKAAGL
WLPPPPPVMVLPQPWGPSPSPIPTTVAPRGAGS
ELCHLPHGVSQHGRDQPRLSQ*SLL*KQA

Frame 2

PESR*VREDPRPLSPLTSPESQVRNGANPGEDP
RSPLPEYTEPEPPHFPQLCSRIGSSCLLSDIRS
ADTTSSSPPAHPDPPLPRV*RTQPGIIPQPRTP
SQTPTSRGRSSGPLPPTQTLLSCRG*SLGFILLP
WITPQSSGFPNPGDSAPGRCYGRHFHSVPGGQR
SRRSPVAGQHGERPQPGGRSWLLPLALGLPRGP
LCCG*DVDHAGGTDQCNEPWG*HPPASGSQSWTP
*YCTEAIAVQGRHQCSE*TRECAPALCLFLGPR
SSGRGPGGKWGPCQHL*QVWRDACGQSQGTPER
ASPRAGREDGPESQPYSIQGHILEGDHPHSAPKW
NPEQTLWH*LQTA*LPDEAQRESLWRAMEGPLA
GQ*HCREGAEGSRLEYKEEQGLQ*RVSPAQDFL
ASKCAPSARCLPVSTCSSSYSHHTLDAVWIPLQC
TT*RHQFRRGPEPGCEVCFGHGKGHGLPTHTRA
PHPTTCTQ*P*CND**GHDCPN*HG*CQVLFPM
SWSHVCTCLGSPRSSAEEA*RHKQTLSRHVEFCS
ASVGTGDTGGTLC*PLQYGDWNEGGIGRPSAYH
PTRYFPSCV*AHEDLHE*RPCKATQI*HDCAYP
*EDAGQVGLEGPCLNSRGVGTWLGECTSPKQQAS
GCLPRLQSWYYPSHGVHPLPPSLPLWPQEGRAQ
SFVTCHMVSPNMGGISPACHNKVYYENRL

Sequence ILK.jAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGAGGATAAA
GCTTGGGGTTCATCCTCCTTCCCTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCA
CTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCA
CTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCAT
CTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACT
ATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAA
AGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGGTCCATCTCCCCCATCCCCTAGCTTGTGTCCTCTCGTCCCTTCCCACCTGTCTTCTCCCTCTGTACCA
CAGCTTAGGTTGTTTTTCTTCCCTAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGC
ACTCGGCCCCGTGAGTCACCACTGTGGGAAGAAGGGTTGTAAAAGGAAATAATCCTGGCCTCTTGGGGCTGGGTTAGGGTGAAGCTGGGTACCTGACCTG
CCCACACTCTTAGGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGG
TGACCCCTGCCCTTCTTGCCCTTCCCTCACTAAACCCCCATAAATTACTTGCTTTGTACCTGTTTTAAGTTTTTCCTCCAGTTAGTGGGCAAGGAAGTGG
CAGCAACATTTCAAGCCTCCTAACCCCTACCTGTCCTGCAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGA
CTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGTAGTGCAAGGCGTAACCTGGAAGCTGCTAGTTCCAAGGAACCCTGAAT
AGCACTGAAAGAGATCTTTTGTACTGGGTCTCAACCACTCCCTCCCTCTTCTAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAG
TCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAA
TTTCCTTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTGACTTTTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTT
TGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAA
GCTCACTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTTACCTCCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCC
GAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGG
GAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGACAGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAA
GAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCC
AATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTGCGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCT
CACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTCTCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTC
GCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAG
CGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTT
GGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCC
CTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAG
TTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRG*
SLGFILLPWITPQSSGFPNPGDSAPGRCYGRHFH
SVPGGQRSRRSPVAGQHGERPQPGGRSWLLPLA
LGLPRGPLCCG*DVDHAGGTDQCNEPWG*HPPA
SGSQSWTP*YCTEAIAVQGRHQCSE*TRECAPAL
CLFLGPRSSGRGPGGKWGPCQHL*QVWRDACGQ
SQGTPERASPRSISPIP*LVSSRPFPPVFSLCT
TA*VVFLP*SGQRRWARISTVFHTRTHSGRGPPA
LGPVSHHCGKKGCKRK*SWPLGAGLG*SWVPDL
PTLLGNGTLNKHSGIDFKQLNFLTKLNENHSGE
VTPALLALPSLNPHKLLALYLF*VFPPVSGQGSG
SNISSLLTPTCPAAMEGPLAGQ*HCREGAEGSR
LEYKEEQGLQ*RVSPAQVVQGVTWKLLVPRNPE
*H*KRSFVLGLNHSLPLLGFSRIQMCSQC*VPAS
LHLLLILLSSHTGCRMDPSTMYYMKAPVSRDVE
FPWGGNGREGASLNYLTFASSQISSWTRARL*S
LLWTWQGAWPSYTH*SPSSHDMHSIAVV*W*GHK
LTPGPGPKSPLPIYDLPPSICFLFLRLMRT*LP
ELAWLMSSSLSNVLVACMHLPG*PPKVSEVIMS
GGKKGPPQK*WKGAETGQARGPEQTSPISPALQK
KPEDTNRRSADMWSFAVLLWELVTREVPFADLS
NMEIGMKVRAQQHTFVLREWLVMVKITVVGLGS
SHICSDIQ*SCPKGQWLLST*QTQIVRLLFFLYS
QVALEGLRPTIPPGISPHVCKLMKICMNEDPAK
RPKFDMIVPILEKMQDK*DWKVLA*TPEVSGHG
WGNAPPQSSRPLVASPASSHGTTPAMGSIPFPHP
YHCGPKRGGLRALSLATWCLPTWEGSAPPVTIK
FIMK

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPEDK
AWGSSSFPGSLHSPQASPIQGTRRRDAAMDDIF
TQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLH
WACREGRSAVVEMLIMRGARINVMNRGDDTPLH
LAASHGHRDIVQKLLQYKADINAVNEHGNVPLH
YACFWGQDQVAEDLVANGALVSICNKYGEMPVDK
AKAPLRELLRGPSPPSPSLCPLVPSHLSSPSVP
QLRLFFFPRAGREDGPESQPYSIQGHILEGDHP
HSAP*VTTVGRRVVKGNNPGLLGLG*GEAGYLTC
PHS*EMEP*TNTLALTSNSLTS*RSSTRITLER
*PLPFLPFPH*TPINYLLCTCFKFFLQLVGKEV
AATFQAS*PLPVLQLWKGRWQGNDIVVKVLKVRD
WSTRKSRDFNEECPRLR*CKA*PGSC*FQGTLN
STERDLLYWVSTTPSLF*DFLASKCAPSARCLP
VSTCSSSYSHHTLDAVWIPLQCTT*RHQ*VGMLN
FLGEEMAEREPL*TI*LLPPLRFRRGPEPGCEV
CFGHGKGHGLPTHTRAPHPTTCTQ*P*CNGEAT
SSLLAQAPKALCLSMTYLLLSVFSSSD**GHDCP
N*HG*CQVLFPMSWSHVCTCLGSPRR*VKSSCR
EVKKDHLRSSGRGQRQDRQGGQNRQALSLQLCR
RSLKTQTDAQQTCGVLQCFCGNW*HGRYPLLTSP
IWRLE*R*EHNSIHLCCGSGW*W*K*L*WALAP
HIFVRIYSNPVPRASGFSLHDRLKL*GCFFSCI
RRWHWKAFGLPSHQVFPLMCVSS*RSA*MKTLQS
DPNLT*LCLSLRRCRTSRTGRSLPELQRCRDMV
GGMHLPKAAGLWLPPPPPVMVLPQPWGPSPSPI
PTTVAPRGAGSELCHLPHGVSQHGRDQPRLSQ*S
LL*K

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPRIK
LGVHPPSLDHSTVLRLPQSRGLGAGTLLWTTFS
LSAGRATQSPFACGWTTRRTTSTRGTIMASPPC
TGPAERAALLWLRC*SCGGHGSM**TVGMTPPCI
WQPVMDTVILYRSYCSTRQTSMQ*MNTGMCPCT
MPVFGAKIKWQRTWWQMGPLSASVTSMERCLWT
KPRHP*ESFSEVHLPHPLACVLSSLPTCLLPLYH
SLGCFSSLERAEKMGQNLNRIPYKDTFWKGTTR
TRPRESPLWEEGL*KEIILASWGWVRVKLGT*P
AHTLRKWNPEQTLWH*LQTA*LPDEAQRESLWRG
DPCPSCPSLTKPP*ITCFVPVLSFSSS*WARKW
QQHFKPPNPYLSCSYGRAAGRAMTLS*RC*RFE
TGVQGRAGTSMKSVPGSGSARRNLEAASSKEP*I
ALKEIFCTGSQPLPPSSRIFSHPNVLPVLGACQ
SPPAPHPTLITHWMPYGSLYNVLHEGTSE*GC*
ISLGRKWQRGSLSELFDFCLLSDFVVDQSQAVKF
ALDMARGMAFLHTLEPLIPRHALNSRSVMVRPQ
AHSWPRPQKPFAYL*LTSFYLFSLPQIDEDMTA
RISMADVKFSFQCPGRMYAPAWVAPEGE*SHHVG
R*KRTTSEVVEGGRDRTGKGARTDKPYLSSSAE
EA*RHKQTLSRHVEFCSASVGTGDTGGTLC*PL
QYGDWNEGESTTAYICVAGVVGDGENNCSGPWLL
TYLFGYTVILSQGPVASLYMTDSNCEAAFFLVF
AGGIGRPSAYHPTRYFPSCV*AHEDLHE*RPCK
ATQI*HDCAYP*EDAGQVGLEGPCLNSRGVGTWL
GECTSPKQQASGCLPRLQSWYYPSHGVHPLPPS
LPLWPQEGRAQSFVTCHMVSPNMGGISPACHNK
VYYEN

Sequence ILK.eAug05

AAGAGCGCCACGGGCGGGGCGGGGCCGGCGGCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCCGGAGAAGGATCCTGCAGCCCGAGTCCCGTCCTCAGG
CTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCAGTCGCCGTTCGCCTGTGGCTGGA
CAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAGATGTTGATC
ATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGAAGCTATTGC
AGTACAAGGCAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGACCTGGTGGC
AAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGGTCCATCTCCCCCA
TCCCCTAGCTTGTGTCCTCTCGTCCCTTCCCACCTGTCTTCTCCCTCTGTACCACAGCTTAGGTTGTTTTTCTTCCCTAGAGCGGGCAGAGAAGATGGGC
CAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACT
TCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAA
GGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCC
TGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGATCCCTCTACAATGTACTACATGAAGGCACCAATTTCGTCGTGG
ACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTCAATAGCCG
TAGTGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTA
GCCCCCGAAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGG
TACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCCTCATGTGTGTAA
GCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAG
GTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCTCCAGTCATGGTA
CTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCC
AACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAACAGGCTG
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

KSATGGAGPAAGCGRGRTGVPRRRILQPESRPQ
ASPIQGTRRRDAAMDDIFTQCREGNAVAVRLWLD
NTENDLNQGDDHGFSPLHWACREGRSAVVEMLI
MRGARINVMNRGDDTPLHLAASHGHRDIVQKLL
QYKADINAVNEHGNVPLHYACFWGQDQVAEDLVA
NGALVSICNKYGEMPVDKAKAPLRELLRGPSPP
SPSLCPLVPSHLSSPSVPQLRLFFFPRAGREDG
PESQPYSIQGHILEGDHPHSAPKWNPEQTLWH*L
QTA*LPDEAQRESLWRAMEGPLAGQ*HCREGAE
GSRLEYKEEQGLQ*RVSPAQDFLASKCAPSARC
LPVSTCSSSYSHHTLDAVWIPLQCTT*RHQFRRG
PEPGCEVCFGHGKGHGLPTHTRAPHPTTCTQ*P
*CND**GHDCPN*HG*CQVLFPMSWSHVCTCLG
SPRSSAEEA*RHKQTLSRHVEFCSASVGTGDTGG
TLC*PLQYGDWNEGGIGRPSAYHPTRYFPSCV*
AHEDLHE*RPCKATQI*HDCAYP*EDAGQVGLE
GPCLNSRGVGTWLGECTSPKQQASGCLPRLQSWY
YPSHGVHPLPPSLPLWPQEGRAQSFVTCHMVSP
NMGGISPACHNKVYYENRL

Frame 1

RAPRAGRGRRRAAGAAGREFPGEGSCSPSPVLR
LPQSRGLGAGTLLWTTFSLSAGRATQSPFACGW
TTRRTTSTRGTIMASPPCTGPAERAALLWLRC*S
CGGHGSM**TVGMTPPCIWQPVMDTVILYRSYC
STRQTSMQ*MNTGMCPCTMPVFGAKIKWQRTWW
QMGPLSASVTSMERCLWTKPRHP*ESFSEVHLPH
PLACVLSSLPTCLLPLYHSLGCFSSLERAEKMG
QNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGID
FKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLK
VRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGA
CQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVV
DQSQAVKFALDMARGMAFLHTLEPLIPRHALNSR
SVMIDEDMTARISMADVKFSFQCPGRMYAPAWV
APEALQKKPEDTNRRSADMWSFAVLLWELVTRE
VPFADLSNMEIGMKVALEGLRPTIPPGISPHVCK
LMKICMNEDPAKRPKFDMIVPILEKMQDK*DWK
VLA*TPEVSGHGWGNAPPQSSRPLVASPASSHG
TTPAMGSIPFPHPYHCGPKRGGLRALSLATWCLP
TWEGSAPPVTIKFIMKTG

Frame 2

ERHGRGGAGGGLRARPDGSSPEKDPAARVPSSG
FPNPGDSAPGRCYGRHFHSVPGGQRSRRSPVAG
QHGERPQPGGRSWLLPLALGLPRGPLCCG*DVD
HAGGTDQCNEPWG*HPPASGSQSWTP*YCTEAIA
VQGRHQCSE*TRECAPALCLFLGPRSSGRGPGG
KWGPCQHL*QVWRDACGQSQGTPERASPRSISP
IP*LVSSRPFPPVFSLCTTA*VVFLP*SGQRRWA
RISTVFHTRTHSGRGPPALGPEMEP*TNTLALT
SNSLTS*RSSTRITLESYGRAAGRAMTLS*RC*
RFETGVQGRAGTSMKSVPGSGFSRIQMCSQC*VP
ASLHLLLILLSSHTGCRMDPSTMYYMKAPISSW
TRARL*SLLWTWQGAWPSYTH*SPSSHDMHSIA
VV**LMRT*LPELAWLMSSSLSNVLVACMHLPG*
PPKLCRRSLKTQTDAQQTCGVLQCFCGNW*HGR
YPLLTSPIWRLE*RWHWKAFGLPSHQVFPLMCV
SS*RSA*MKTLQSDPNLT*LCLSLRRCRTSRTGR
SLPELQRCRDMVGGMHLPKAAGLWLPPPPPVMV
LPQPWGPSPSPIPTTVAPRGAGSELCHLPHGVS
QHGRDQPRLSQ*SLL*KQA

Sequence ILK.shed1.aAug05

AGCCCGAGTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCCTCACTTCTCCTGAGTCCCAAGTAAGGAACGGAGCCAACCCTGGGGAGGACCC
CCGGTCCCCTCTCCCAGAGTATACGGAGCCTGAACCTCCCCACTTCCCCCAACTCTGTTCGCGGATAGGGTCTAGTTGCCTGCTCTCGGACATCCGTTCA
GCAGACACTACCTCTTCGTCACCCCCTGCCCACCCTGACCCGCCTTTACCTCGCGTCTAGAGGACACAGCCAGGGATCATCCCGCAGCCCCGAACTCCTT
CACAGACCCCCACTAGCCGGGGACGCAGCTCAGGCCCCCTACCCCCAACACAAACACTTCTCTCCTGTAGAGGATAAAGCTTGGGGTTCATCCTCCTTCC
CTGGATCACTCCACAGTCCTCAGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGC
AGTCGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACCAGGGGTGAGCTGAAACGGTTGGTGGATGAGAGGAAGGCTAGAGATCTCCTGGC
TACGTGGAGTGGAGTGCTCATGTCTGGTGGTGGCGGCTGCCTTTGCTAGCCAGTGTAATGAGTGCTAAGCATAGCCTGTGGGGGGCAGAGGGTTTTCACA
GAGGACGCAGTTTGAGCTGAATCTTGACTGCAGAATAAGAGTTTCACAGGCAGAGGCTACAGAGAGCTTTCCAGCCTCAGTAGACTGCATGGCCAAAGGC
TAGGGGGCAAGGCACAGAGCAGAGAGAACAGGAAATTGTCTGGAGTTCCATATGGCTGGAGGATAGATGATCTCTGTGGGTCGGAGCATTGGGTACAAGA
GGAAAAGAACAGGACATAAGACTGTAGAGGTCTCCAAGGATCAGCCAGATCATGCAAGCATATTTAGGCTATAAGAAGGTCTTTATTTTAAAAGCAAGGT
TTTAAAGCTGTATAGTGACATAATGAGATTGTCCATTTTTCAGTATCGTCTTGGATGCTTTGTGAAGAGCAGGTGGAAAGGAGGCAATTGCCTAGTTCAT
CGTAGAAGTAATGATGTCTTGGACTAGAATTAGGGTGAGTGAAAAAGAGAAGTGATCAAATTCCAGAAGTCTTTAGGACGAAGAATTGTGGAACTTGGTG
TGGGGAGTGAGTAAGGGCAAAGATGAGGACCAGGGTTCTGGCTTGGGAACTTGGTTGTTTTTACTGAGATGGAGAAAACTGGAGGATGAGGCATTTTATT
TTGGACATGTTAAAGTTAAGGTGACAATACAGCAAGGTGGAAATGTTGAGTGTGTTGTTGGTTATGCAGATTTGCAATTCAGGGGAGGAATCTGACTTGG
AGACACAGATTTGAGAGCTATCAGCATATAGATAGCATATATATATCATATATATAGATGATACTTGAAGACGTGGTTGTGAAGGAGAACGTCTCAGGAG
AGTGGAAGGCAAGAGGTCAGGGGACAGGAAGCCTGCACGACAGAAAAGGAGCAACCGCAAGTTGAAAAAGAAATAGGAAAATGTGTGAGTAAAGCTTACA
GAAGAGAATGTTTTAATGAAGGGGAGGTAGTCAACGGCAGTACAGGCTACTGAGAGATCAAAGAACATTAATATTTTAAAGTAGCCATTGAATTTACAGT
TGGGTTTTTTTTTTTTAAGTTAAGGGGTACATGTGCAGGTTTGTTGGATGGGTAAACTCAGGTCATGGAGGTTTGTTGTGCAGATCATTTCATCACCCAG
GTATTAAGCCGTGGCACCCATTAGTTATTTTTCCTGATCCCTCCCTCTTCCTACCCGCCCCACTCTGGTAGGCCCCAGTGTCTGTTGCTCCCCTCAGTGT
GCAGTTAGGATGTATTTGACCATCTGTGAGTGTTGTTTCAGAATAATGGGTGAAGAAATCAGACTACATTGGGTTCCTTAATTTAAGGCACTATGATGAA
CACCTTCTGTGCTGGGTGCTAGAGTCCAGAATCTGACATAATCTCTGCTCTCGATACAGCAGATTTGTGGCAGATTGAAAAGTAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCTGTCTCTA
CTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCGGAGGCTGAGGCAGGAGAACTGCTTGAACCCGGGAAGCAGAGG
CTGCAGTGAGCCAAGATCATGCCACTGCCCTCCAGCCTGGGCCACAGAGCAAGACTCTGTCTTAAAAAAGAAAAAGAAAACAAAAGTTGAGAGGTGAGCA
AATAGTGAAAGTGAATGTACACCAGTTCTACAAGGTTGGCTGAGATAGGAAGGCAAGAAGAGCAGTAGTGATGGTGACTCAGAGTGGCAAAATCAAATTC
TTTATTTTTTAAAATTGGTGGAGTTTAGTTTTTAGGTTTGACAGGTCAGGATCACCTGTCATCTTAGTCTAGACTTCACTGGTTCCCATTAGGTTCTACA
CTATTTCTCTTTAATACTTTGCAAAGTCATTTGTTCCATTTTTCATATAATTCTCAAAGGGTACCCTGATAAAGACAGTAAGCACTGTTACTGTTTTGTT
GGTGAGGAAATAGAGGCTTAGGCAGTTGCCCAGTGGGCCTAGCATCTAGGAAGACTCTAGCTGAGTCTAGGAAGACTCTAGGAAGATGCTGCCAGAAGGA
AAAGGGGTGGAATTAATGAAACTGGAAGGTTGTGGTGCTGGTTTGAGGAGTAAAGTATGGGGGCCAAAGTTGGCTATATGCTGGATATGAAGAGGGGGTT
AATTCCTTGCAGGTCTTCTTGAGATAGAAGTCCAGGCCCTGAGGTGGCAGGCAGCCTGATAGTGAACAGAACCCTTGTGCCCATACTTTTGCCCCCCGAG
TTTGGCCTGCCCTGGCGCCACAGGCAGTACTGGAAGCTGATAAGTCAGGGCACAAATTAAAGGTCTAGGAGGCAAGACCAACTGATAAACAGGGGGCGTA
ATGCTTCCTGGGGATAATCCCATCTCAAGGAAAAGCTTTTGGCTATTTCTGTGTTAGCAGATGCGAGCAAGTTGTGGAGGAAAATGATTAACTTAAAGGC
CACACCCCCCAACCCCTTCAGCTGTACGGGCATCTGGATGGCCAGACCCCTGATCAGCTCCAGGCCTTGCCTAGAGTCGCACACAGGAAGTGACCACAAC
ACTAAGGCATCCGGAGGCTGCTGGCCCAGACCACGGACCGCCCCCTGCTCCGCCCCTTGAATCTGCAGCCCCGAACTGGAGGGAATTTCCTTTTATGGCC
CCAGGCTGTCAGGCAGGCCCAGCTCCAAACCAATTGTTTTGTTTTGTTTGTATACTTTACTTTATAAAATACATATTTCTTGGAAAAGAAAAAAATCAGG
TATAGTTTTAATCCCAAAACAGCCATTCTCATTTTCTTCTGTTTTCTATGCACAGGATTGCTAAGTAGGGGAATCCTGCTTTGCATGGTGGTTTGTTATC
TACCTCATCAGTAGTCAAAAGCATTTCTCCTTTTCAACATAAACCCTTCCAAAACATCATTTAAATTCCATTCCATTTTTAGATGTTAGTTTCAGTACCA
GAGCCAAATAGTAAGTTTGTTCCCTCTTCTATAAGTTGTGGCCTGCCTTCTCCAAGACACCCTTCTCCCCCACTAACATGCACTGAACAGCTGCTGTCAA
TCCATTCCCTCAAGAAACTTAAAGGTCTAACAGACAAGACAGTCCATTAACAGATTTTTACAATCCAGTGCAACAAGTGCTGAAGTAGGGGGACATATAA
GATGTGGTGGAAAACAGAAAGGACCAATAGATGTTGCAGAAGGGGTGCAAGAGAAACCAGGGGAAGAGCACTACCACCTAAGGAAATGAGATGTGGGATA
TGGTGAAGATAACACATTTTTTTATAGAGGTTGTTGAGATATCTAGGTGGTTGGTTTGGTTTGAAGCTCAGGGGAAGGTCTGAAATGGACAGCTTTGGGA
GTTGCTGGCATGAATGAGAATCAAAGTCCTAGAGAGGTAAGCCTTCCCAGAGAGTATGTAATTATCAGTTTTTCAGGAATCAAAACCTTTGCCCCATCCC
ACCTCCAGCTCAATGACCATTGCCCCTTCCTCAAAGGGACGATCATGGCTTCTCCCCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGTTGAG
ATGTTGATCATGCGGGGGGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAGCCAGTCATGGACACCGTGATATTGTACAGA
AGGTACGTACAAACTCCTTCGTCATCCACATCACATACATGCCATGAGGGTCAGTCACAGGCACTGTAACATACAGTAGAAAGCATGTGTGCTCTTCCCC
CTTTTCCCATGCCCTGACACCAGTATCTCATTTGGAACTGACTGTACTTTCTGCCTCTTCTTTTTGTCTGGCCATGGGGTCCAGCTATTGCAGTACAAGG
CAGACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGGCCAAGATCAAGTGGCAGAGGTGAGTACTCAGCCCTTAAT
TCCTGAGATGGGTAGGAAGTAAAGTCTGAGCCTTGGTGGGAGATTTTGGAACCCTCAACCCATTCTGTCAGTACTACTGTGTGACACTTACAGGATTAAG
TTCTACATTTGTGCATTCATGGTTGGTTCAGTGACTGCCAGCGAGGTAGCAGTGGCTCTCATCATAATGGCCTTTTCATTCCAGGACCTGGTGGCAAATG
GGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGGTCCATCTCCCCCATCCCC
TAGCTTGTGTCCTCTCGTCCCTTCCCACCTGTCTTCTCCCTCTGTACCACAGCTTAGGTTGTTTTTCTTCCCTAGAGCGGGCAGAGAAGATGGGCCAGAA
TCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGTGAGTCACCACTGTGGGAAGAAGGGTTGTAAAAGGAAATA
ATCCTGGCCTCTTGGGGCTGGGTTAGGGTGAAGCTGGGTACCTGACCTGCCCACACTCTTAGGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTC
AAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGGTGACCCCTGCCCTTCTTGCCCTTCCCTCACTAAACCCCCATAAATTACTTG
CTTTGTACCTGTTTTAAGTTTTTCCTCCAGTTAGTGGGCAAGGAAGTGGCAGCAACATTTCAAGCCTCCTAACCCCTACCTGTCCTGCAGCTATGGAAGG
GCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAG
GTAGTGCAAGGCGTAACCTGGAAGCTGCTAGTTCCAAGGAACCCTGAATAGCACTGAAAGAGATCTTTTGTACTGGGTCTCAACCACTCCCTCCCTCTTC
TAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGCCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGA
TCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTAGGGATGTTGAATTTCCTTGGGGAGGAAATGGCAGAGAGGGAGCCTCTCTGAACTATTTGACT
TTTGCCTCCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCT
CATCCCACGACATGCACTCAATAGCCGTAGTGTAATGGTGAGGCCACAAGCTCACTCCTGGCCCAGGCCCCAAAAGCCCTTTGCCTATCTATGACTTACC
TCCTTCTATCTGTTTTCTCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGT
ATGCACCTGCCTGGGTAGCCCCCGAAGGTGAGTGAAGTCATCATGTCGGGAGGTAAAAAAGGACCACCTCAGAAGTAGTGGAAGGGGGCAGAGACAGGAC
AGGCAAGGGGGCCAGAACAGACAAGCCCTATCTCTCCAGCTCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGT
GCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAATATGGAGATTGGAATGAAGGTGAGAGCACAACAGCATACATTTGTGTTG
CGGGAGTGGTTGGTGATGGTGAAAATAACTGTAGTGGGCCTTGGCTCCTCACATATTTGTTCGGATATACAGTAATCCTGTCCCAAGGGCCAGTGGCTTC
TCTCTACATGACAGACTCAAATTGTGAGGCTGCTTTTTTTCTTGTATTCGCAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCC
TCATGTGTGTAAGCTCATGAAGATCTGCATGAATGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTGAGAAGATGCAGGACAAG
TAGGACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACCTCCCCAAAGCAGCAGGCCTCTGGTTGCCTCCCCCGCCT
CCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCCTTCCCCCATCCCTACCACTGTGGCCCCAAGAGGGGCGGGCTCAGAGCTTTGTCACTTGCCAC
ATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATTATGAAAAC
  • ILK.F11 (forward primer)
  • ILK.R12 (reverse primer)
  • Intron retention

Frame 0

SPSPGECERTRAPCHPSLLLSPK*GTEPTLGRT
PGPLSQSIRSLNLPTSPNSVRG*GLVACSRTSVQ
QTLPLRHPLPTLTRLYLASRGHSQGSSRSPELL
HRPPLAGDAAQAPYPQHKHFSPVEDKAWGSSSF
PGSLHSPQASPIQGTRRRDAAMDDIFTQCREGNA
VAVRLWLDNTENDLNQG*AETVGG*EEG*RSPG
YVEWSAHVWWWRLPLLASVMSAKHSLWGAEGFH
RGRSLS*ILTAE*EFHRQRLQRAFQPQ*TAWPKA
RGQGTEQREQEIVWSSIWLEDR*SLWVGALGTR
GKEQDIRL*RSPRISQIMQAYLGYKKVFILKAR
F*SCIVT**DCPFFSIVLDAL*RAGGKEAIA*FI
VEVMMSWTRIRVSEKEK*SNSRSL*DEELWNLV
WGVSKGKDEDQGSGLGTWLFLLRWRKLEDEAFY
FGHVKVKVTIQQGGNVECVVGYADLQFRGGI*LG
DTDLRAISI*IAYIYHIYR*YLKTWL*RRTSQE
SGRQEVRGQEACTTEKEQPQVEKEIGKCVSKAY
RRECFNEGEVVNGSTGY*EIKEH*YFKVAIEFTV
GFFFFKLRGTCAGLLDG*TQVMEVCCADHFITQ
VLSRGTH*LFFLIPPSSYPPHSGRPQCLLLPSV
CS*DVFDHL*VLFQNNG*RNQTTLGSLI*GTMMN
TFCAGC*SPESDIISALDTADLWQIEK*AGRGG
SRL*SQHFGRPRLVDHEVRSSRPA*PTW*NPVS
TKNTKISQAWWRAPVIPATRRLRQENCLNPGSRG
CSEPRSCHCPPAWATEQDSVLKKKKKTKVER*A
NSESECTPVLQGWLR*EGKKSSSDGDSEWQNQI
LYFLKLVEFSF*V*QVRITCHLSLDFTGSH*VLH
YFSLILCKVICSIFHIILKGYPDKDSKHCYCFV
GEEIEA*AVAQWA*HLGRL*LSLGRL*EDAARR
KRGGINETGRLWCWFEE*SMGAKVGYMLDMKRGL
IPCRSS*DRSPGPEVAGSLIVNRTLVPILLPPE
FGLPWRHRQYWKLISQGTN*RSRRQDQLINRGR
NASWG*SHLKEKLLAISVLADASKLWRKMINLKA
TPPNPFSCTGIWMARPLISSRPCLESHTGSDHN
TKASGGCWPRPRTAPCSAP*ICSPELEGISFYG
PRLSGRPSSKPIVLFCLYTLLYKIHISWKRKKSG
IVLIPKQPFSFSSVFYAQDC*VGESCFAWWFVI
YLISSQKHFSFST*TLPKHHLNSIPFLDVSFST
RAK**VCSLFYKLWPAFSKTPFSPTNMH*TAAVN
PFPQET*RSNRQDSPLTDFYNPVQQVLK*GDI*
DVVENRKDQ*MLQKGCKRNQGKSTTT*GNEMWD
MVKITHFFIEVVEISRWLVWFEAQGKV*NGQLWE
LLA*MRIKVLER*AFPESM*LSVFQESKPLPHP
TSSSMTIAPSSKGRSWLLPLALGLPRGPLCCG*
DVDHAGGTDQCNEPWG*HPPASGSQSWTP*YCTE
GTYKLLRHPHHIHAMRVSHRHCNIQ*KACVLFP
LFPCPDTSISFGTDCTFCLFFLSGHGVQLLQYK
ADINAVNEHGNVPLHYACFWGQDQVAEVSTQPLI
PEMGRK*SLSLGGRFWNPQPILSVLLCDTYRIK
FYICAFMVGSVTASEVAVALIIMAFSFQDLVAN
GALVSICNKYGEMPVDKAKAPLRELLRGPSPPSP
SLCPLVPSHLSSPSVPQLRLFFFPRAGREDGPE
SQPYSIQGHILEGDHPHSAP*VTTVGRRVVKGN
NPGLLGLG*GEAGYLTCPHS*EMEP*TNTLALTS
NSLTS*RSSTRITLER*PLPFLPFPH*TPINYL
LCTCFKFFLQLVGKEVAATFQAS*PLPVLQLWK
GRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLR
*CKA*PGSC*FQGTLNSTERDLLYWVSTTPSLF
*DFLASKCAPSARCLPVSTCSSSYSHHTLDAVW
IPLQCTT*RHQ*VGMLNFLGEEMAEREPL*TI*L
LPPLRFRRGPEPGCEVCFGHGKGHGLPTHTRAP
HPTTCTQ*P*CNGEATSSLLAQAPKALCLSMTY
LLLSVFSSSD**GHDCPN*HG*CQVLFPMSWSHV
CTCLGSPRR*VKSSCREVKKDHLRSSGRGQRQD
RQGGQNRQALSLQLCRRSLKTQTDAQQTCGVLQ
CFCGNW*HGRYPLLTSPIWRLE*R*EHNSIHLCC
GSGW*W*K*L*WALAPHIFVRIYSNPVPRASGF
SLHDRLKL*GCFFSCIRRWHWKAFGLPSHQVFP
LMCVSS*RSA*MKTLQSDPNLT*LCLSLRRCRTS
RTGRSLPELQRCRDMVGGMHLPKAAGLWLPPPP
PVMVLPQPWGPSPSPIPTTVAPRGAGSELCHLP
HGVSQHGRDQPRLSQ*SLL*K

Frame 1

ARVPVSARGPAPPVTPHFS*VPSKERSQPWGGP
PVPSPRVYGA*TSPLPPTLFADRV*LPALGHPF
SRHYLFVTPCPP*PAFTSRLEDTARDHPAAPNSF
TDPH*PGTQLRPPTPNTNTSLL*RIKLGVHPPS
LDHSTVLRLPQSRGLGAGTLLWTTFSLSAGRAT
QSPFACGWTTRRTTSTRGELKRLVDERKARDLLA
TWSGVLMSGGGGCLC*PV**VLSIACGGQRVFT
EDAV*AES*LQNKSFTGRGYRELSSLSRLHGQR
LGGKAQSRENRKLSGVPYGWRIDDLCGSEHWVQE
EKNRT*DCRGLQGSARSCKHI*AIRRSLF*KQG
FKAV**HNEIVHFSVSSWMLCEEQVERRQLPSS
S*K**CLGLELG*VKKRSDQIPEVFRTKNCGTWC
GE*VRAKMRTRVLAWELGCFY*DGENWRMRHFI
LDMLKLR*QYSKVEMLSVLLVMQICNSGEESDL
ETQI*ELSAYR*HIYIIYIDDT*RRGCEGERLRR
VEGKRSGDRKPARQKRSNRKLKKK*ENV*VKLT
EENVLMKGR*STAVQATERSKNINILK*PLNLQ
LGFFFLS*GVHVQVCWMGKLRSWRFVVQIISSPR
Y*AVAPISYFS*SLPLPTRPTLVGPSVCCSPQC
AVRMYLTICECCFRIMGEEIRLHWVP*FKAL**
TPSVLGARVQNLT*SLLSIQQICGRLKSRPGAVA
HACNPSTLGGRGWWITRSGVRDQPDQHGETLSL
LKIQKLARRGGVRL*SQLLGG*GRRTA*TREAE
AAVSQDHATALQPGPQSKTLS*KRKRKQKLRGEQ
IVKVNVHQFYKVG*DRKARRAVVMVTQSGKIKF
FIF*NWWSLVFRFDRSGSPVILV*TSLVPIRFY
TISL*YFAKSFVPFFI*FSKGTLIKTVSTVTVLL
VRK*RLRQLPSGPSI*EDSS*V*EDSRKMLPEG
KGVELMKLEGCGAGLRSKVWGPKLAICWI*RGG
*FLAGLLEIEVQALRWQAA***TEPLCPYFCPPS
LACPGATGSTGS**VRAQIKGLGGKTN**TGGV
MLPGDNPISRKSFWLFLC*QMRASCGGK*LT*R
PHPPTPSAVRASGWPDP*SAPGLA*SRTQEVTTT
LRHPEAAGPDHGPPPAPPLESAAPNWREFPFMA
PGCQAGPAPNQLFCFVCILYFIKYIFLGKEKNQ
V*F*SQNSHSHFLLFSMHRIAK*GNPALHGGLLS
TSSVVKSISPFQHKPFQNII*IPFHF*MLVSVP
EPNSKFVPSSISCGLPSPRHPSPPLTCTEQLLS
IHSLKKLKGLTDKTVH*QIFTIQCNKC*SRGTYK
MWWKTERTNRCCRRGARETRGRALPPKEMRCGI
W*R*HIFL*RLLRYLGGWFGLKLRGRSEMDSFG
SCWHE*ESKS*RGKPSQRVCNYQFFRNQNLCPIP
PPAQ*PLPLPQRDDHGFSPLHWACREGRSAVVE
MLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ
KVRTNSFVIHITYMP*GSVTGTVTYSRKHVCSSP
FSHALTPVSHLELTVLSASSFCLAMGSSYCSTR
QTSMQ*MNTGMCPCTMPVFGAKIKWQR*VLSP*
FLRWVGSKV*ALVGDFGTLNPFCQYYCVTLTGLS
STFVHSWLVQ*LPAR*QWLSS*WPFHSRTWWQM
GPLSASVTSMERCLWTKPRHP*ESFSEVHLPHP
LACVLSSLPTCLLPLYHSLGCFSSLERAEKMGQN
LNRIPYKDTFWKGTTRTRPRESPLWEEGL*KEI
ILASWGWVRVKLGT*PAHTLRKWNPEQTLWH*L
QTA*LPDEAQRESLWRGDPCPSCPSLTKPP*ITC
FVPVLSFSSS*WARKWQQHFKPPNPYLSCSYGR
AAGRAMTLS*RC*RFETGVQGRAGTSMKSVPGS
GSARRNLEAASSKEP*IALKEIFCTGSQPLPPSS
RIFSHPNVLPVLGACQSPPAPHPTLITHWMPYG
SLYNVLHEGTSE*GC*ISLGRKWQRGSLSELFD
FCLLSDFVVDQSQAVKFALDMARGMAFLHTLEPL
IPRHALNSRSVMVRPQAHSWPRPQKPFAYL*LT
SFYLFSLPQIDEDMTARISMADVKFSFQCPGRM
YAPAWVAPEGE*SHHVGR*KRTTSEVVEGGRDRT
GKGARTDKPYLSSSAEEA*RHKQTLSRHVEFCS
ASVGTGDTGGTLC*PLQYGDWNEGESTTAYICV
AGVVGDGENNCSGPWLLTYLFGYTVILSQGPVAS
LYMTDSNCEAAFFLVFAGGIGRPSAYHPTRYFP
SCV*AHEDLHE*RPCKATQI*HDCAYP*EDAGQ
VGLEGPCLNSRGVGTWLGECTSPKQQASGCLPRL
QSWYYPSHGVHPLPPSLPLWPQEGRAQSFVTCH
MVSPNMGGISPACHNKVYYEN

Frame 2

PESR*VREDPRPLSPLTSPESQVRNGANPGEDP
RSPLPEYTEPEPPHFPQLCSRIGSSCLLSDIRS
ADTTSSSPPAHPDPPLPRV*RTQPGIIPQPRTP
SQTPTSRGRSSGPLPPTQTLLSCRG*SLGFILLP
WITPQSSGFPNPGDSAPGRCYGRHFHSVPGGQR
SRRSPVAGQHGERPQPGVS*NGWWMRGRLEISW
LRGVECSCLVVAAAFASQCNEC*A*PVGGRGFSQ
RTQFELNLDCRIRVSQAEATESFPASVDCMAKG
*GARHRAERTGNCLEFHMAGG*MISVGRSIGYK
RKRTGHKTVEVSKDQPDHASIFRL*EGLYFKSKV
LKLYSDIMRLSIFQYRLGCFVKSRWKGGNCLVH
RRSNDVLD*N*GE*KREVIKFQKSLGRRIVELG
VGSE*GQR*GPGFWLGNLVVFTEMEKTGG*GILF
WTC*S*GDNTARWKC*VCCWLCRFAIQGRNLTW
RHRFESYQHIDSIYISYI*MILEDVVVKENVSG
EWKARGQGTGSLHDRKGATAS*KRNRKMCE*SLQ
KRMF**RGGSQRQYRLLRDQRTLIF*SSH*IYS
WVFFF*VKGYMCRFVGWVNSGHGGLLCRSFHHP
GIKPWHPLVIFPDPSLFLPAPLW*APVSVAPLSV
QLGCI*PSVSVVSE*WVKKSDYIGFLNLRHYDE
HLLCWVLESRI*HNLCSRYSRFVAD*KVGRARW
LTPVIPALWEAEAGGSRGQEFETSLTNMVKPCLY
*KYKN*PGVVACACNPSYSEAEAGELLEPGKQR
LQ*AKIMPLPSSLGHRARLCLKKEKENKS*EVS
K**K*MYTSSTRLAEIGRQEEQ**W*LRVAKSNS
LFFKIGGV*FLGLTGQDHLSS*SRLHWFPLGST
LFLFNTLQSHLFHFSYNSQRVP**RQ*ALLLFC
W*GNRGLGSCPVGLASRKTLAESRKTLGRCCQKE
KGWN**NWKVVVLV*GVKYGGQSWLYAGYEEGV
NSLQVFLR*KSRP*GGRQPDSEQNPCAHTFAPR
VWPALAPQAVLEADKSGHKLKV*EARPTDKQGA*
CFLGIIPSQGKAFGYFCVSRCEQVVEEND*LKG
HTPQPLQLYGHLDGQTPDQLQALPRVAHRK*PQ
H*GIRRLLAQTTDRPLLRPLNLQPRTGGNFLLWP
QAVRQAQLQTNCFVLFVYFTL*NTYFLEKKKIR
YSFNPKTAILIFFCFLCTGLLSRGILLCMVVCY
LPHQ*SKAFLLFNINPSKTSFKFHSIFRC*FQYQ
SQIVSLFPLL*VVACLLQDTLLPH*HALNSCCQ
SIPSRNLKV*QTRQSINRFLQSSATSAEVGGHI
RCGGKQKGPIDVAEGVQEKPGEEHYHLRK*DVGY
GEDNTFFYRGC*DI*VVGLV*SSGEGLKWTALG
VAGMNENQSPREVSLPREYVIISFSGIKTFAPS
HLQLNDHCPFLKGTIMASPPCTGPAERAALLWLR
C*SCGGHGSM**TVGMTPPCIWQPVMDTVILYR
RYVQTPSSSTSHTCHEGQSQAL*HTVESMCALP
PFPMP*HQYLIWN*LYFLPLLFVWPWGPAIAVQG
RHQCSE*TRECAPALCLFLGPRSSGRGEYSALN
S*DG*EVKSEPWWEILEPSTHSVSTTV*HLQD*
VLHLCIHGWFSDCQRGSSGSHHNGLFIPGPGGKW
GPCQHL*QVWRDACGQSQGTPERASPRSISPIP
*LVSSRPFPPVFSLCTTA*VVFLP*SGQRRWAR
ISTVFHTRTHSGRGPPALGPVSHHCGKKGCKRK*
SWPLGAGLG*SWVPDLPTLLGNGTLNKHSGIDF
KQLNFLTKLNENHSGEVTPALLALPSLNPHKLL
ALYLF*VFPPVSGQGSGSNISSLLTPTCPAAMEG
PLAGQ*HCREGAEGSRLEYKEEQGLQ*RVSPAQ
VVQGVTWKLLVPRNPE*H*KRSFVLGLNHSLPL
LGFSRIQMCSQC*VPASLHLLLILLSSHTGCRMD
PSTMYYMKAPVSRDVEFPWGGNGREGASLNYLT
FASSQISSWTRARL*SLLWTWQGAWPSYTH*SP
SSHDMHSIAVV*W*GHKLTPGPGPKSPLPIYDLP
PSICFLFLRLMRT*LPELAWLMSSSLSNVLVAC
MHLPG*PPKVSEVIMSGGKKGPPQK*WKGAETG
QARGPEQTSPISPALQKKPEDTNRRSADMWSFAV
LLWELVTREVPFADLSNMEIGMKVRAQQHTFVL
REWLVMVKITVVGLGSSHICSDIQ*SCPKGQWL
LST*QTQIVRLLFFLYSQVALEGLRPTIPPGISP
HVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
*DWKVLA*TPEVSGHGWGNAPPQSSRPLVASPA
SSHGTTPAMGSIPFPHPYHCGPKRGGLRALSLAT
WCLPTWEGSAPPVTIKFIMK

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