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Sequences

Sequence FGFR3.cAug05

CGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCT CCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGG GGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTC CTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACT TCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGAC ACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCC TGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCT CGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCAT CCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGG CTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCT CCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGA GCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCC GCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCG GGAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTT TCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTAC CAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGA TCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTT GTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCT GTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATG CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGAGTACCTGGACCTGTCGGCGCC TTTCGAGCAGTACTCCCCGGGTGGCCAGGACACCCCCAGCTCCAGCTCCTCAGGGGACGACTCCGTGTTTGCCCACGACCTGCTGCCCCCGGCCCCACCC AGCAGTGGGGGCTCGCGGACGTGAAGGGCCACTGGTCCCCAACAATGTGAGGGGTCCCTAGCAGCCCACCCTGCTGCTGGTGCACAGCCACTCCCCGGCA TGAGACTCAGTGCAGATGGAGAGACAGCTACACAGAGCTTTGGTCTGTGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGCACATCCGCGTGTGCCTGT GTGCGTGCGCATCTTGCCTCCAGGTGCAGAGGTACCCTGGGTGTCCCCGCTGCTGTGCAACGGTCTCCTGACTGGTGCTGCAGCACCGAGGGGCCTTTGT TCTGGGGGGACCCAGTGCAGAATGTAAGTGGGCCCACCCGGTGGGACCCCCGTGGGGCAGGGAGCTGGGCCCGACATGGCTCCGGCCTCTGCCTTTGCAC CACGGGACATCACAGGGTGGGCCTCGGCCCCTCCCACACCCAAAGCTGAGCCTGCAGGGAAGCCCCACATGTCCAGCACCTTGTGCCTGGGGTGTTAGTG GCACCGCCTCCCCACCTCCAGGCTTTCCCACTTCCCACCCTGCCCCTCAGAGACTGAAATTACGGGTACCTGAAGATGGGAGCCTTTACCTTTTATGCAA AAGGTTTATTCCGGAAACTAGTGTACATTTCTATAAATAGATGCTGTGTATATGGTATATATACATATATATATATAACATATATGGAAGAGGAAAAGGC TGGTACAACGGAGGCCTGCGACCCTGGGGGCACAGGAGGCAGGCATGGCCCTGGGCGGGGCGTGGGGGGGCGTGGAGGGAGGCCCCAGGGGGTCTCACCC ATGCAAGCAGAGGACCAGGGCCTTTTCTGGCACCGCAGTTTTGTTTTAAAACTGGACCTGTATATTTGTAAAGCTATTTATGGGCCCCTGGCACTCTTGT TCCCACACCCCAACACTTCCAGCATTTAGCTGGCCACATGGCGGAGAGTTTTAATTTTTAACTTATTGACAACCGAGAAGGTTTATCCCGCCGATAGAGG GACGGCCAAGAATGTACGTCCAGCCTGCCCCGGAGCTGGAGGATCCCCTCCAAGCCTAAAAGGTTGTTAATAGTTGGAGGTGATTCCAGTGAAGATATTT TATTTCCTTTGTCCTTTTTCAGGAGAATTAGATTTCTATAGGATTTTTCTTTAGGAGATTTATTTTTTGGACTTCAAAGCAAGCTGGTATTTTCATACAA ATTCTTCTAATTGCTGTGTGTCCCAGGCAGGGAGACGGTTTCCAGGGAGGGGCCGGCCCTGTGTGCAGGTTCCGATGTTATTAGATGTTACAAGTTTATA TATATCTATATATATAATTTATTGAGTTTTTACAAGATGTATTTGTTGTAGACTTAACACTTCTTACGCAATGCTTCTAGAGTTTTATAGCCTGGACTGC TACCTTTCAAAGCTTGGAGGGAAGCCGTGAATTCAGTTGGTTCGTTCTGTACTGTTACTGGGCCCTGAGTCTGGGCAGCTGTCCCTTGCTTGCCTGCAGG GCCATGGCTCAGGGTGGTCTCTTCTTGGGGCCCAGTGCATGGTGGCCAGAGGTGTCACCCAAACCGGCAGGTGCGATTTTGTTAACCCAGCGACGAACTT TCCGAAAAATAAAGACACCTGGTTGCTAACCTGG

FGFR3.F3 (forward primer)
FGFR3.R3 (reverse primer)
Multiple exon skipping

Frame 0

RALPEDAAAPAPAMGAPACALALCVAVAIVAGA SSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSG DAVELSCPPPGGGPMGPTVWVKDGTGLVPSERV LVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWT RPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS WLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPI LQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQW LKHVEVNGSKVGPDGTPYVTVLKVSLESNASMS SNTPLVRIARLSSGEGPTLANVSELELPADPKWE LSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREF LRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAY QVARGMEYLASQKCIHRDLAARNVLVTEDNVMK IADFGLARDVHNLDYYKKTTNGRLPVKWMAPEAL FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP VEELFKLLKEGHRMDKPANCTHDLYMIMRECWH AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAP FEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPP SSGGSRT*RATGPQQCEGSLAAHPAAGAQPLPG MRLSADGETATQSFGLCVCVCVCVCVCAHPRVPV CVRILPPGAEVPWVSPLLCNGLLTGAAAPRGLC SGGTQCRM*VGPPGGTPVGQGAGPDMAPASAFA PRDITGWASAPPTPKAEPAGKPHMSSTLCLGC*W HRLPTSRLSHFPPCPSETEITGT*RWEPLPFMQ KVYSGN*CTFL*IDAVYMVYIHIYI*HIWKRKR LVQRRPATLGAQEAGMALGGAWGGVEGGPRGSHP CKQRTRAFSGTAVLF*NWTCIFVKLFMGPWHSC SHTPTLPAFSWPHGGEF*FLTY*QPRRFIPPIE GRPRMYVQPAPELEDPLQA*KVVNSWR*FQ*RYF ISFVLFQEN*ISIGFFFRRFIFWTSKQAGIFIQ ILLIAVCPRQGDGFQGGAGPVCRFRCY*MLQVY IYLYI*FIEFLQDVFVVDLTLLTQCF*SFIAWTA TFQSLEGSREFSWFVLYCYWALSLGSCPLLACR AMAQGGLFLGPSAWWPEVSPKPAGAILLTQRRT FRKIKTPGC*P

Frame 1

ARCLRTPRPPPPPWAPLPAPSRSAWPWPSWPAP PRSPWGRSSASWGERQKSRAQSPASRSSWSSAA GMLWS*AVPRPGVVPWGPLSGSRMAQGWCPRSVS WWGPSGCRC*MPPTRTPGPTAAGSGSRSAYCAT SVCG*QTLHPREMTKTGRTRLRTQVWTQGPLTG HGPSGWTRSCWPCRPPTPSASAAQPLATPLPPSP G*RTAGSSAASTALEASSCGISSGAWSWKAWCP RTAATTPASWRTSLAASGRRTRWTCWSAPRTGP SCRRGCRPTRRRCWAATWSSTARCTVTHSPTSSG SSTWR*MAARWARTAHPTLPCSRCPWSPTRP*A PTHHWCASQGCPQGRAPRWPMSPSSSCLPTPNG SCLGPG*PWASPLGRAASARWSWRRPSALTRTGP PSLSP*P*RC*KTMPLTRTCRTWCLRWR**R*S GNTKTSSTCWAPARRAGPCTCWWSTRPRVTCGS FCGRGGPRAWTTPSTPASRPRSSSPSRTWCPVPT RWPGAWSTWPPRSASTGTWLPAMCW*PRTT**R SQTSGWPGTCTTSTTTRRRPTAGCP*SGWRLRP CLTESTLTRVTSGPLGSCSGRSSRWGAPRTPASL WRSSSSC*RRATAWTSPPTAHTTCT*SCGSAGM PRPPRGPPSSSWWRTWTVSLP*RPPTSTWTCRR LSSSTPRVARTPPAPAPQGTTPCLPTTCCPRPHP AVGARGREGPLVPNNVRGP*QPTLLLVHSHSPA *DSVQMERQLHRALVCVCVCACVCVCVHIRVCL CACASCLQVQRYPGCPRCCATVS*LVLQHRGAFV LGGPSAECKWAHPVGPPWGRELGPTWLRPLPLH HGTSQGGPRPLPHPKLSLQGSPTCPAPCAWGVS GTASPPPGFPTSHPAPQRLKLRVPEDGSLYLLCK RFIPETSVHFYK*MLCIWYIYIYIYNIYGRGKG WYNGGLRPWGHRRQAWPWAGRGGAWREAPGGLT HASRGPGPFLAPQFCFKTGPVYL*SYLWAPGTLV PTPQHFQHLAGHMAESFNF*LIDNREGLSRR*R DGQECTSSLPRSWRIPSKPKRLLIVGGDSSEDI LFPLSFFRRIRFL*DFSLGDLFFGLQSKLVFSYK FF*LLCVPGRETVSREGPALCAGSDVIRCYKFI YIYIYNLLSFYKMYLL*T*HFLRNASRVL*PGL LPFKAWREAVNSVGSFCTVTGP*VWAAVPCLPAG PWLRVVSSWGPVHGGQRCHPNRQVRFC*PSDEL SEK*RHLVANL

Frame 2

RAA*GRRGPRPRHGRPCLRPRALRGRGHRGRRL LGVLGDGAARRGASGRSPGPRARPAGAVGLRQR GCCGAELSPARGWSHGAHCLGQGWHRAGALGAC PGGAPAAAGAECLPRGLRGLQLPAAAHAARTVPL QCAGDRRSILGR*RRRGGRG*GHRCGHRGPLLD TARADGQEAAGRAGRQHRPLPLPSRWQPHSLHL LAEERQGVPRRAPHWRHQAAASAVEPGHGKRGAL GPRQLHLRRGEQVWQHPADVHAGRAGALPAPAH PAGGAAGQPDGGAGQRRGVPLQGVQ*RTAPHPV AQARGGEWQQGGPGRHTLRYRAQGVPGVQRVHEL QHTTGAHRKAVLRGGPHAGQCLRARAACRPQMG AVSGPADPGQAPWGGLLRPGGHGGGHRH*QGPG RQACHRSREDAERRCH*QGPVGPGV*DGDDEDDR ETQKHHQPAGRLHAGRAPVRAGGVRGQG*PAGV SAGAAAPGPGLLLRHLQAARGAAHLQGPGVLCL PGGPGHGVLGLPEVHPQGPGCPQCAGDRGQRDED RRLRAGPGRAQPRLLQEDDQRPAAREVDGA*GL V*PSLHSPE*RLVLWGPALGDLHAGGLPVPRHP CGGALQAAEGGPPHGQARQLHTRPVHDHAGVLAC RALPEAHLQAAGGGPGPCPYRDVHRRVPGPVGA FRAVLPGWPGHPQLQLLRGRLRVCPRPAAPGPT QQWGLADVKGHWSPTM*GVPSSPPCCWCTATPRH ETQCRWRDSYTELWSVCVCVRVCVCVCTSACAC VRAHLASRCRGTLGVPAAVQRSPDWCCSTEGPL FWGDPVQNVSGPTRWDPRGAGSWARHGSGLCLCT TGHHRVGLGPSHTQS*ACREAPHVQHLVPGVLV APPPHLQAFPLPTLPLRD*NYGYLKMGAFTFYA KGLFRKLVYISINRCCVYGIYTYIYITYMEEEKA GTTEACDPGGTGGRHGPGRGVGGRGGRPQGVSP MQAEDQGLFWHRSFVLKLDLYICKAIYGPLALL FPHPNTSSI*LATWRRVLIFNLLTTEKVYPADRG TAKNVRPACPGAGGSPPSLKGC**LEVIPVKIF YFLCPFSGELDFYRIFL*EIYFLDFKASWYFHT NSSNCCVSQAGRRFPGRGRPCVQVPMLLDVTSLY ISIYIIY*VFTRCICCRLNTSYAMLLEFYSLDC YLSKLGGKP*IQLVRSVLLLGPESGQLSLACLQ GHGSGWSLLGAQCMVARGVTQTGRCDFVNPATNF PKNKDTWLLTW

Sequence FGFR3.bAug05

CGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCT CCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGG GGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTC CTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACT TCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGAC ACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCC TGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCT CGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCAT CCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGG CTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGC TAGAGGTTCTCTCCTTGCACAACGTCACCTTTGAGGACGCCGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCT GGTGGTGCTGCCAGCCGAGGAGGAGCTGGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATC CTGGTGGTGGCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGC GACAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGT CTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTC ATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGG ACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCT GGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAG CAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCC GCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGG CCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATC TTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACAC ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT GACGTCCACCGACGAGTACCTGGACCTGTCGGCGCCTTTCGAGCAGTACTCCCCGGGTGGCCAGGACACCCCCAGCTCCAGCTCCTCAGGGGACGACTCC GTGTTTGCCCACGACCTGCTGCCCCCGGCCCCACCCAGCAGTGGGGGCTCGCGGACGTGAAGGGCCACTGGTCCCCAACAATGTGAGGGGTCCCTAGCAG CCCACCCTGCTGCTGGTGCACAGCCACTCCCCGGCATGAGACTCAGTGCAGATGGAGAGACAGCTACACAGAGCTTTGGTCTGTGTGTGTGTGTGTGCGT GTGTGTGTGTGTGTGTGCACATCCGCGTGTGCCTGTGTGCGTGCGCATCTTGCCTCCAGGTGCAGAGGTACCCTGGGTGTCCCCGCTGCTGTGCAACGGT CTCCTGACTGGTGCTGCAGCACCGAGGGGCCTTTGTTCTGGGGGGACCCAGTGCAGAATGTAAGTGGGCCCACCCGGTGGGACCCCCGTGGGGCAGGGAG CTGGGCCCGACATGGCTCCGGCCTCTGCCTTTGCACCACGGGACATCACAGGGTGGGCCTCGGCCCCTCCCACACCCAAAGCTGAGCCTGCAGGGAAGCC CCACATGTCCAGCACCTTGTGCCTGGGGTGTTAGTGGCACCGCCTCCCCACCTCCAGGCTTTCCCACTTCCCACCCTGCCCCTCAGAGACTGAAATTACG GGTACCTGAAGATGGGAGCCTTTACCTTTTATGCAAAAGGTTTATTCCGGAAACTAGTGTACATTTCTATAAATAGATGCTGTGTATATGGTATATATAC ATATATATATATAACATATATGGAAGAGGAAAAGGCTGGTACAACGGAGGCCTGCGACCCTGGGGGCACAGGAGGCAGGCATGGCCCTGGGCGGGGCGTG GGGGGGCGTGGAGGGAGGCCCCAGGGGGTCTCACCCATGCAAGCAGAGGACCAGGGCCTTTTCTGGCACCGCAGTTTTGTTTTAAAACTGGACCTGTATA TTTGTAAAGCTATTTATGGGCCCCTGGCACTCTTGTTCCCACACCCCAACACTTCCAGCATTTAGCTGGCCACATGGCGGAGAGTTTTAATTTTTAACTT ATTGACAACCGAGAAGGTTTATCCCGCCGATAGAGGGACGGCCAAGAATGTACGTCCAGCCTGCCCCGGAGCTGGAGGATCCCCTCCAAGCCTAAAAGGT TGTTAATAGTTGGAGGTGATTCCAGTGAAGATATTTTATTTCCTTTGTCCTTTTTCAGGAGAATTAGATTTCTATAGGATTTTTCTTTAGGAGATTTATT TTTTGGACTTCAAAGCAAGCTGGTATTTTCATACAAATTCTTCTAATTGCTGTGTGTCCCAGGCAGGGAGACGGTTTCCAGGGAGGGGCCGGCCCTGTGT GCAGGTTCCGATGTTATTAGATGTTACAAGTTTATATATATCTATATATATAATTTATTGAGTTTTTACAAGATGTATTTGTTGTAGACTTAACACTTCT TACGCAATGCTTCTAGAGTTTTATAGCCTGGACTGCTACCTTTCAAAGCTTGGAGGGAAGCCGTGAATTCAGTTGGTTCGTTCTGTACTGTTACTGGGCC CTGAGTCTGGGCAGCTGTCCCTTGCTTGCCTGCAGGGCCATGGCTCAGGGTGGTCTCTTCTTGGGGCCCAGTGCATGGTGGCCAGAGGTGTCACCCAAAC CGGCAGGTGCGATTTTGTTAACCCAGCGACGAACTTTCCGAAAAATAAAGACACCTGGTTGCTAACCTGG

FGFR3.F3 (forward primer)
FGFR3.R3 (reverse primer)
Multiple exon skipping

Frame 0

RALPEDAAAPAPAMGAPACALALCVAVAIVAGA SSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSG DAVELSCPPPGGGPMGPTVWVKDGTGLVPSERV LVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWT RPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS WLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPI LQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQW LKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE LEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWL VVLPAEEELVEADEAGSVYAGILSYGVGFFLFI LVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK RQVSLESNASMSSNTPLVRIARLSSGEGPTLANV SELELPADPKWELSRARLTLGKPLGEGCFGQVV MAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS DLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVL VEYAAKGNLREFLRARRPPGLDYSFDTCKPPEE QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNG RLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV TSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDS VFAHDLLPPAPPSSGGSRT*RATGPQQCEGSLA AHPAAGAQPLPGMRLSADGETATQSFGLCVCVCV CVCVCAHPRVPVCVRILPPGAEVPWVSPLLCNG LLTGAAAPRGLCSGGTQCRM*VGPPGGTPVGQG AGPDMAPASAFAPRDITGWASAPPTPKAEPAGKP HMSSTLCLGC*WHRLPTSRLSHFPPCPSETEIT GT*RWEPLPFMQKVYSGN*CTFL*IDAVYMVYI HIYI*HIWKRKRLVQRRPATLGAQEAGMALGGAW GGVEGGPRGSHPCKQRTRAFSGTAVLF*NWTCI FVKLFMGPWHSCSHTPTLPAFSWPHGGEF*FLT Y*QPRRFIPPIEGRPRMYVQPAPELEDPLQA*KV VNSWR*FQ*RYFISFVLFQEN*ISIGFFFRRFI FWTSKQAGIFIQILLIAVCPRQGDGFQGGAGPV CRFRCY*MLQVYIYLYI*FIEFLQDVFVVDLTLL TQCF*SFIAWTATFQSLEGSREFSWFVLYCYWA LSLGSCPLLACRAMAQGGLFLGPSAWWPEVSPK PAGAILLTQRRTFRKIKTPGC*P

Frame 1

ARCLRTPRPPPPPWAPLPAPSRSAWPWPSWPAP PRSPWGRSSASWGERQKSRAQSPASRSSWSSAA GMLWS*AVPRPGVVPWGPLSGSRMAQGWCPRSVS WWGPSGCRC*MPPTRTPGPTAAGSGSRSAYCAT SVCG*QTLHPREMTKTGRTRLRTQVWTQGPLTG HGPSGWTRSCWPCRPPTPSASAAQPLATPLPPSP G*RTAGSSAASTALEASSCGISSGAWSWKAWCP RTAATTPASWRTSLAASGRRTRWTCWSAPRTGP SCRRGCRPTRRRCWAATWSSTARCTVTHSPTSSG SSTWR*MAARWARTAHPTLPCSRRRALTPPTRS *RFSPCTTSPLRTPGSTPAWRAILLGFLITLRG WWCCQPRRSWWRLTRRAVCMQASSATGWASSCSS WWWRL*RSAACAAPPRKAWAPPPCTRSPASRSS DRCPWSPTRP*APTHHWCASQGCPQGRAPRWPM SPSSSCLPTPNGSCLGPG*PWASPLGRAASARWS WRRPSALTRTGPPSLSP*P*RC*KTMPLTRTCR TWCLRWR**R*SGNTKTSSTCWAPARRAGPCTC WWSTRPRVTCGSFCGRGGPRAWTTPSTPASRPRS SSPSRTWCPVPTRWPGAWSTWPPRSASTGTWLP AMCW*PRTT**RSQTSGWPGTCTTSTTTRRRPT AGCP*SGWRLRPCLTESTLTRVTSGPLGSCSGRS SRWGAPRTPASLWRSSSSC*RRATAWTSPPTAH TTCT*SCGSAGMPRPPRGPPSSSWWRTWTVSLP *RPPTSTWTCRRLSSSTPRVARTPPAPAPQGTTP CLPTTCCPRPHPAVGARGREGPLVPNNVRGP*Q PTLLLVHSHSPA*DSVQMERQLHRALVCVCVCA CVCVCVHIRVCLCACASCLQVQRYPGCPRCCATV S*LVLQHRGAFVLGGPSAECKWAHPVGPPWGRE LGPTWLRPLPLHHGTSQGGPRPLPHPKLSLQGS PTCPAPCAWGVSGTASPPPGFPTSHPAPQRLKLR VPEDGSLYLLCKRFIPETSVHFYK*MLCIWYIY IYIYNIYGRGKGWYNGGLRPWGHRRQAWPWAGR GGAWREAPGGLTHASRGPGPFLAPQFCFKTGPVY L*SYLWAPGTLVPTPQHFQHLAGHMAESFNF*L IDNREGLSRR*RDGQECTSSLPRSWRIPSKPKR LLIVGGDSSEDILFPLSFFRRIRFL*DFSLGDLF FGLQSKLVFSYKFF*LLCVPGRETVSREGPALC AGSDVIRCYKFIYIYIYNLLSFYKMYLL*T*HF LRNASRVL*PGLLPFKAWREAVNSVGSFCTVTGP *VWAAVPCLPAGPWLRVVSSWGPVHGGQRCHPN RQVRFC*PSDELSEK*RHLVANL

Frame 2

RAA*GRRGPRPRHGRPCLRPRALRGRGHRGRRL LGVLGDGAARRGASGRSPGPRARPAGAVGLRQR GCCGAELSPARGWSHGAHCLGQGWHRAGALGAC PGGAPAAAGAECLPRGLRGLQLPAAAHAARTVPL QCAGDRRSILGR*RRRGGRG*GHRCGHRGPLLD TARADGQEAAGRAGRQHRPLPLPSRWQPHSLHL LAEERQGVPRRAPHWRHQAAASAVEPGHGKRGAL GPRQLHLRRGEQVWQHPADVHAGRAGALPAPAH PAGGAAGQPDGGAGQRRGVPLQGVQ*RTAPHPV AQARGGEWQQGGPGRHTLRYRAQDGGR*HHRQGA RGSLLAQRHL*GRRGVHLPGGQFYWVFSSLCVA GGAASRGGAGGG*RGGQCVCRHPQLRGGLLPVH PGGGGCDALPPAQPPQERPGLPHRAQDLPLPAQA TGVPGVQRVHELQHTTGAHRKAVLRGGPHAGQC LRARAACRPQMGAVSGPADPGQAPWGGLLRPGG HGGGHRH*QGPGRQACHRSREDAERRCH*QGPVG PGV*DGDDEDDRETQKHHQPAGRLHAGRAPVRA GGVRGQG*PAGVSAGAAAPGPGLLLRHLQAARG AAHLQGPGVLCLPGGPGHGVLGLPEVHPQGPGCP QCAGDRGQRDEDRRLRAGPGRAQPRLLQEDDQR PAAREVDGA*GLV*PSLHSPE*RLVLWGPALGD LHAGGLPVPRHPCGGALQAAEGGPPHGQARQLHT RPVHDHAGVLACRALPEAHLQAAGGGPGPCPYR DVHRRVPGPVGAFRAVLPGWPGHPQLQLLRGRL RVCPRPAAPGPTQQWGLADVKGHWSPTM*GVPSS PPCCWCTATPRHETQCRWRDSYTELWSVCVCVR VCVCVCTSACACVRAHLASRCRGTLGVPAAVQR SPDWCCSTEGPLFWGDPVQNVSGPTRWDPRGAGS WARHGSGLCLCTTGHHRVGLGPSHTQS*ACREA PHVQHLVPGVLVAPPPHLQAFPLPTLPLRD*NY GYLKMGAFTFYAKGLFRKLVYISINRCCVYGIYT YIYITYMEEEKAGTTEACDPGGTGGRHGPGRGV GGRGGRPQGVSPMQAEDQGLFWHRSFVLKLDLY ICKAIYGPLALLFPHPNTSSI*LATWRRVLIFNL LTTEKVYPADRGTAKNVRPACPGAGGSPPSLKG C**LEVIPVKIFYFLCPFSGELDFYRIFL*EIY FLDFKASWYFHTNSSNCCVSQAGRRFPGRGRPCV QVPMLLDVTSLYISIYIIY*VFTRCICCRLNTS YAMLLEFYSLDCYLSKLGGKP*IQLVRSVLLLG PESGQLSLACLQGHGSGWSLLGAQCMVARGVTQT GRCDFVNPATNFPKNKDTWLLTW