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Sequences

Sequence GATA3.cAug05

GGGGCGCCTCGGAGCCGCGTGCCCTCCGCCCCGGGGTGCCCATTGCGCAGAGCGTGGCCTGGAGACCCGCGAGCCGGGGAAGGTCGCCGTGGAGTCCCGA CCAGAGGCCGGGGTTGGGGTCGGTGCAGACCGAGGGCTGGTTTCCTTGACTGTGGGAGAAACGCCGGGAGCCGGAGTGACCCGAGGAGGGACTCCGCCTC CGAGCGGCTGAGGACCCCGGTGCAGAGGAGCCTGGCTCGCAGAATTGCAGAGTCGTCGCCCCTTTTTACAACCTGGTCCCGTTTTATTCTGCCGTACCCA GTTTTTGGATTTTTGTCTTCCCCTTCTTCTCTTTGCTAAACGACCCCTCCAAGATAATTTTTAAAAAACCTTCTCCTTTGCTCACCTTTGCTTCCCAGCC TTCCCATCCCCCCACCGAAAGCAAATCATTCAACGACCCCCGACCCTCCGACGGCAGGAGCCCCCCGACCTCCCAGGCGGACCGCCCTCCCTCCCCGCGC GCGGGTTCCGGGCCCGGCGAGAGGGCGCGAGCACAGCCGAGGCCATGGAGGTGACGGCGGACCAGCCGCGCTGGGTGAGCCACCACCACCCCGCCGTGCT CAACGGGCAGCACCCGGACACGCACCACCCGGGCCTCAGCCACTCCTACATGGACGCGGCGCAGTACCCGCTGCCGGAGGAGGTGGATGTGCTTTTTAAC ATCGACGGTCAAGGCAACCACGTCCCGCCCTACTACGGAAACTCGGTCAGGGCCACGGTGCAGAGGTACCCTCCGACCCACCACGGGAGCCAGGTGTGCC GCCCGCCTCTGCTTCATGGATCCCTACCCTGGCTGGACGGCGGCAAAGCCCTGGGCAGCCACCACACCGCCTCCCCCTGGAATCTCAGCCCCTTCTCCAA GACGTCCATCCACCACGGCTCCCCGGGGCCCCTCTCCGTCTACCCCCCGGCCTCGTCCTCCTCCTTGTCGGGGGGCCACGCCAGCCCGCACCTCTTCACC TTCCCGCCCACCCCGCCGAAGGACGTCTCCCCGGACCCATCGCTGTCCACCCCAGGCTCGGCCGGCTCGGCCCGGCAGGACGAGAAAGAGTGCCTCAAGT ACCAGGTGCCCCTGCCCGACAGCATGAAGCTGGAGTCGTCCCACTCCCGTGGCAGCATGACCGCCCTGGGTGGAGCCTCCTCGTCGACCCACCACCCCAT CACCACCTACCCGCCCTACGTGCCCGAGTACAGCTCCGGACTCTTCCCCCCCAGCAGCCTGCTGGGCGGCTCCCCCACCGGCTTCGGATGCAAGTCCAGG CCCAAGGCCCGGTCCAGCACAGTCTGCAGCCAGGAGAGCAGGGACGTCCTGTGCGAACTGTCAGACCACCACAACCACACTCTGGAGGAGGAATGCCAAT GGGGACCCTGTCTGCAATGCCTGTGGGCTCTACTACAAGCTTCACAATATTAACAGACCCCTGACTATGAAGAAGGAAGGCATCCAGACCAGAAACCGAA AAATGTCTAGCAAATCCAAAAAGTGCAAAAAAGTGCATGACTCACTGGAGGACTTCCCCAAGAACAGCTCGTTTAACCCGGCCGCCCTCTCCAGACACAT GTCCTCCCTGAGCCACATCTCGCCCTTCAGCCACTCCAGCCACATGCTGACCACGCCCACGCCGATGCACCCGCCATCCAGCCTGTCCTTTGGACCACAC CACCCCTCCAGCATGGTCACCGCCATGGGTTAGAGCCCTGCTCGATGCTCACAGGGCCCCCAGCGAGAGTCCCTGCAGTCCCTTTCGACTTGCATTTTTG CAGGAGCAGTATCATGAAGCCTAAACGCGATGGATATATGTTTTTGAAGGCAGAAAGCAAAATTATGTTTGCCACTTTGCAAAGGAGCTCACTGTGGTGT CTGTGTTCCAACCACTGAATCTGGACCCCATCTGTGAATAAGCCATTCTGACTCATATCCCCTATTTAACAGGGTCTCTAGTGCTGTGAAAAAAAAAATG CTGAACATTGCATATAACTTATATTGTAAGAAATACTGTACAATGACTTTATTGCATCTGGGTAGCTGTAAGGCATGAAGGATGCCAAGAAGTTTAAGGA ATATGGGAGAAATAGTGTGGAAATTAAGAAGAAACTAGGTCTGATATTCAAATGGACAAACTGCCAGTTTTGTTTCCTTTCACTGGCCACAGTTGTTTGA TGCATTAAAAGAAAATAAAAAAAAGAAAAAAGAGAAAAGAAAAAAAAAGAAAAAAGTTGTAGGCGAATCATTTGTTCAAAGCTGTTGGCCTCTGCAAAGG AAATACCAGTTCTGGGCAATCAGTGTTACCGTTCACCAGTTGCCGTTGAGGGTTTCAGAGAGCCTTTTTCTAGGCCTACATGCTTTGTGAACAAGTCCCT GTAATTGTTGTTTGTATGTATAATTCAAAGCACCAAAATAAGAAAAGATGTAGATTTATTTCATCATATTATACAGACCGAACTGTTGTATAAATTTATT TACTGCTAGTCTTAAGAACTGCTTTCTTTCGTTTGTTTGTTTCAATATTTTCCTTCTCTCTCAATTTTTGGTTGAATAAACTAGATTACATTCAGTTGGC CTAAGGTGGTTGTGCTCGGAGGGTTTCTTGTTTCTTTTCCATTTTGTTTTTGGATGATATTTATTAAATAGCTTCTAAGAGTCCGGCGGCATCTGTCTTG TCCCTATTCCTGCAGCCTGTGCTGAGGGTAGCAGTGTATGAGCTACCAGCGTGCATGTCAGCGACCCTGGCCCGACAGGCCACGTCCTGCAATCGGCCCG GCTGCCTCTTCGCCCTGTCGTGTTCTGTGTTAGTGATCACTGCCTTTAATACAGTCTGTTGGAATAATATTATAAGCATAATAATAAAGTGAAAATATTT TAAAACTACAAAATGACATCGTATCCACGTGGTGGCCGAGCTCTTCTAGAATCTGGTAGCTCTAGCTAATTTCAGAGAAAGGAGTTAAAAGAAACAACTT AACAACC

GATA3.F2 (forward primer)
GATA3.R5 (reverse primer)
Single exon skipping

Frame 0

GAPRSRVPSAPGCPLRRAWPGDPRAGEGRRGVP TRGRGWGRCRPRAGFLDCGRNAGSRSDPRRDSAS ERLRTPVQRSLARRIAESSPLFTTWSRFILPYP VFGFLSSPSSLC*TTPPR*FLKNLLLCSPLLPS LPIPPPKANHSTTPDPPTAGAPRPPRRTALPPRA RVPGPARGREHSRGHGGDGGPAALGEPPPPRRA QRAAPGHAPPGPQPLLHGRGAVPAAGGGGCAF* HRRSRQPRPALLRKLGQGHGAEVPSDPPREPGVP PASASWIPTLAGRRQSPGQPPHRLPLESQPLLQ DVHPPRLPGAPLRLPPGLVLLLVGGPRQPAPLH LPAHPAEGRLPGPIAVHPRLGRLGPAGRERVPQV PGAPARQHEAGVVPLPWQHDRPGWSLLVDPPPH HHLPALRARVQLRTLPPQQPAGRLPHRLRMQVQ AQGPVQHSLQPGEQGRPVRTVRPPQPHSGGGMPM GTLSAMPVGSTTSFTILTDP*L*RRKASRPETE KCLANPKSAKKCMTHWRTSPRTARLTRPPSPDT CPP*ATSRPSATPATC*PRPRRCTRHPACPLDHT TPPAWSPPWVRALLDAHRAPSESPCSPFRLAFL QEQYHEA*TRWIYVFEGRKQNYVCHFAKELTVV SVFQPLNLDPICE*AILTHIPYLTGSLVL*KKKC *TLHITYIVRNTVQ*LYCIWVAVRHEGCQEV*G IWEK*CGN*EETRSDIQMDKLPVLFPFTGHSCL MH*KKIKKRKKRKEKKRKKL*ANHLFKAVGLCKG NTSSGQSVLPFTSCR*GFQRAFF*AYMLCEQVP VIVVCMYNSKHQNKKRCRFISSYYTDRTVV*IY LLLVLRTAFFRLFVSIFSFSLNFWLNKLDYIQLA *GGCARRVSCFFSILFLDDIY*IASKSPAASVL SLFLQPVLRVAVYELPACMSATLARQATSCNRP GCLFALSCSVLVITAFNTVCWNNIISIIIK*KYF KTTK*HRIHVVAELF*NLVALANFRERS*KKQL NN

Frame 1

GRLGAACPPPRGAHCAERGLETREPGKVAVESR PEAGVGVGADRGLVSLTVGETPGAGVTRGGTPP PSG*GPRCRGAWLAELQSRRPFLQPGPVLFCRTQ FLDFCLPLLLFAKRPLQDNF*KTFSFAHLCFPA FPSPHRKQIIQRPPTLRRQEPPDLPGGPPSLPA RGFRARREGASTAEAMEVTADQPRWVSHHHPAVL NGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN IDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVC RPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSK TSIHHGSPGPLSVYPPASSSSLSGGHASPHLFT FPPTPPKDVSPDPSLSTPGSAGSARQDEKECLK YQVPLPDSMKLESSHSRGSMTALGGASSSTHHPI TTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSR PKARSSTVCSQESRDVLCELSDHHNHTLEEECQ WGPCLQCLWALLQASQY*QTPDYEEGRHPDQKPK NV*QIQKVQKSA*LTGGLPQEQLV*PGRPLQTH VLPEPHLALQPLQPHADHAHADAPAIQPVLWTT PPLQHGHRHGLEPCSMLTGPPARVPAVPFDLHFC RSSIMKPKRDGYMFLKAESKIMFATLQRSSLWC LCSNH*IWTPSVNKPF*LISPI*QGL*CCEKKN AEHCI*LIL*EILYNDFIASG*L*GMKDAKKFKE YGRNSVEIKKKLGLIFKWTNCQFCFLSLATVV* CIKRK*KKEKREKKKKEKSCRRIICSKLLASAK EIPVLGNQCYRSPVAVEGFREPFSRPTCFVNKSL *LLFVCIIQSTKIRKDVDLFHHIIQTELLYKFI YC*S*ELLSFVCLFQYFPSLSIFG*IN*ITFSW PKVVVLGGFLVSFPFCFWMIFIK*LLRVRRHLSC PYSCSLC*G*QCMSYQRACQRPWPDRPRPAIGP AASSPCRVLC**SLPLIQSVGIIL*A***SENI LKLQNDIVSTWWPSSSRIW*L*LISEKGVKRNNL TT

Frame 2

GASEPRALRPGVPIAQSVAWRPASRGRSPWSPD QRPGLGSVQTEGWFP*LWEKRREPE*PEEGLRL RAAEDPGAEEPGSQNCRVVAPFYNLVPFYSAVP SFWIFVFPFFSLLNDPSKIIFKKPSPLLTFASQP SHPPTESKSFNDPRPSDGRSPPTSQADRPPSPR AGSGPGERARAQPRPWR*RRTSRAG*ATTTPPC STGSTRTRTTRASATPTWTRRSTRCRRRWMCFLT STVKATTSRPTTETRSGPRCRGTLRPTTGARCA ARLCFMDPYPGWTAAKPWAATTPPPPGISAPSP RRPSTTAPRGPSPSTPRPRPPPCRGATPARTSSP SRPPRRRTSPRTHRCPPQARPARPGRTRKSASS TRCPCPTA*SWSRPTPVAA*PPWVEPPRRPTTP SPPTRPTCPSTAPDSSPPAACWAAPPPASDASPG PRPGPAQSAARRAGTSCANCQTTTTTLWRRNAN GDPVCNACGLYYKLHNINRPLTMKKEGIQTRNR KMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHM SSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPH HPSSMVTAMG*SPARCSQGPQRESLQSLSTCIF AGAVS*SLNAMDICF*RQKAKLCLPLCKGAHCGV CVPTTESGPHL*ISHSDSYPLFNRVSSAVKKKM LNIAYNLYCKKYCTMTLLHLGSCKA*RMPRSLR NMGEIVWKLRRN*V*YSNGQTASFVSFHWPQLFD ALKENKKKKKEKRKKKKKVVGESFVQSCWPLQR KYQFWAISVTVHQLPLRVSESLFLGLHAL*TSP CNCCLYV*FKAPK*EKM*IYFIILYRPNCCINLF TASLKNCFLSFVCFNIFLLSQFLVE*TRLHSVG LRWLCSEGFLFLFHFVFG*YLLNSF*ESGGICL VPIPAACAEGSSV*ATSVHVSDPGPTGHVLQSAR LPLRPVVFCVSDHCL*YSLLE*YYKHNNKVKIF *NYKMTSYPRGGRALLESGSSS*FQRKELKETT *Q

Sequence GATA3.aAug05

GAACACTGAGCTGCCTGGCGCCGTCTTGATACTTTCAGAAAGAATGCATTCCCTGTAAAAAAAAAAAAAAAATACTGAGAGAGGGAGAGAGAGAGAGAAG AAGAGAGAGAGACGGAGGGAGAGCGAGACAGAGCGAGCAACGCAATCTGACCGAGCAGGTCGTACGCCGCCGCCTCCTCCTCCTCTCTGCTCTTCGCTAC CCAGGTGACCCGAGGAGGGACTCCGCCTCCGAGCGGCTGAGGACCCCGGTGCAGAGGAGCCTGGCTCGCAGAATTGCAGAGTCGTCGCCCCTTTTTACAA CCTGGTCCCGTTTTATTCTGCCGTACCCAGTTTTTGGATTTTTGTCTTCCCCTTCTTCTCTTTGCTAAACGACCCCTCCAAGATAATTTTTAAAAAACCT TCTCCTTTGCTCACCTTTGCTTCCCAGCCTTCCCATCCCCCCACCGAAAGCAAATCATTCAACGACCCCCGACCCTCCGACGGCAGGAGCCCCCCGACCT CCCAGGCGGACCGCCCTCCCTCCCCGCGCGCGGGTTCCGGGCCCGGCGAGAGGGCGCGAGCACAGCCGAGGCCATGGAGGTGACGGCGGACCAGCCGCGC TGGGTGAGCCACCACCACCCCGCCGTGCTCAACGGGCAGCACCCGGACACGCACCACCCGGGCCTCAGCCACTCCTACATGGACGCGGCGCAGTACCCGC TGCCGGAGGAGGTGGATGTGCTTTTTAACATCGACGGTCAAGGCAACCACGTCCCGCCCTACTACGGAAACTCGGTCAGGGCCACGGTGCAGAGGTACCC TCCGACCCACCACGGGAGCCAGGTGTGCCGCCCGCCTCTGCTTCATGGATCCCTACCCTGGCTGGACGGCGGCAAAGCCCTGGGCAGCCACCACACCGCC TCCCCCTGGAATCTCAGCCCCTTCTCCAAGACGTCCATCCACCACGGCTCCCCGGGGCCCCTCTCCGTCTACCCCCCGGCCTCGTCCTCCTCCTTGTCGG GGGGCCACGCCAGCCCGCACCTCTTCACCTTCCCGCCCACCCCGCCGAAGGACGTCTCCCCGGACCCATCGCTGTCCACCCCAGGCTCGGCCGGCTCGGC CCGGCAGGACGAGAAAGAGTGCCTCAAGTACCAGGTGCCCCTGCCCGACAGCATGAAGCTGGAGTCGTCCCACTCCCGTGGCAGCATGACCGCCCTGGGT GGAGCCTCCTCGTCGACCCACCACCCCATCACCACCTACCCGCCCTACGTGCCCGAGTACAGCTCCGGACTCTTCCCCCCCAGCAGCCTGCTGGGCGGCT CCCCCACCGGCTTCGGATGCAAGTCCAGGCCCAAGGCCCGGTCCAGCACAGAAGGCAGGGAGTGTGTGAACTGTGGGGCAACCTCGACCCCACTGTGGCG GCGAGATGGCACGGGACACTACCTGTGCAACGCCTGCGGGCTCTATCACAAAATGAACGGACAGAACCGGCCCCTCATTAAGCCCAAGCGAAGGCTGTCT GCAGCCAGGAGAGCAGGGACGTCCTGTGCGAACTGTCAGACCACCACAACCACACTCTGGAGGAGGAATGCCAATGGGGACCCTGTCTGCAATGCCTGTG GGCTCTACTACAAGCTTCACAATATTAACAGACCCCTGACTATGAAGAAGGAAGGCATCCAGACCAGAAACCGAAAAATGTCTAGCAAATCCAAAAAGTG CAAAAAAGTGCATGACTCACTGGAGGACTTCCCCAAGAACAGCTCGTTTAACCCGGCCGCCCTCTCCAGACACATGTCCTCCCTGAGCCACATCTCGCCC TTCAGCCACTCCAGCCACATGCTGACCACGCCCACGCCGATGCACCCGCCATCCAGCCTGTCCTTTGGACCACACCACCCCTCCAGCATGGTCACCGCCA TGGGTTAGAGCCCTGCTCGATGCTCACAGGGCCCCCAGCGAGAGTCCCTGCAGTCCCTTTCGACTTGCATTTTTGCAGGAGCAGTATCATGAAGCCTAAA CGCGATGGATATATGTTTTTGAAGGCAGAAAGCAAAATTATGTTTGCCACTTTGCAAAGGAGCTCACTGTGGTGTCTGTGTTCCAACCACTGAATCTGGA CCCCATCTGTGAATAAGCCATTCTGACTCATATCCCCTATTTAACAGGGTCTCTAGTGCTGTGAAAAAAAAAATGCTGAACATTGCATATAACTTATATT GTAAGAAATACTGTACAATGACTTTATTGCATCTGGGTAGCTGTAAGGCATGAAGGATGCCAAGAAGTTTAAGGAATATGGGAGAAATAGTGTGGAAATT AAGAAGAAACTAGGTCTGATATTCAAATGGACAAACTGCCAGTTTTGTTTCCTTTCACTGGCCACAGTTGTTTGATGCATTAAAAGAAAATAAAAAAAAG AAAAAAGAGAAAAGAAAAAAAAAGAAAAAAGTTGTAGGCGAATCATTTGTTCAAAGCTGTTGGCCTCTGCAAAGGAAATACCAGTTCTGGGCAATCAGTG TTACCGTTCACCAGTTGCCGTTGAGGGTTTCAGAGAGCCTTTTTCTAGGCCTACATGCTTTGTGAACAAGTCCCTGTAATTGTTGTTTGTATGTATAATT CAAAGCACCAAAATAAGAAAAGATGTAGATTTATTTCATCATATTATACAGACCGAACTGTTGTATAAATTTATTTACTGCTAGTCTTAAGAACTGCTTT CTTTCGTTTGTTTGTTTCAATATTTTCCTTCTCTCTCAATTTTTGGTTGAATAAACTAGATTACATTCAGTTGGCCTAAGGTGGTTGTGCTCGGAGGGTT TCTTGTTTCTTTTCCATTTTGTTTTTGGATGATATTTATTAAATAGCTTCTAAGAGTCCGGCGGCATCTGTCTTGTCCCTATTCCTGCAGCCTGTGCTGA GGGTAGCAGTGTATGAGCTACCAGCGTGCATGTCAGCGACCCTGGCCCGACAGGCCACGTCCTGCAATCGGCCCGGCTGCCTCTTCGCCCTGTCGTGTTC TGTGTTAGTGATCACTGCCTTTAATACAGTCTGTTGGAATAATATTATAAGCATAATAATAAAGTGAAAATATTTTAAAACTACAAAATGACATCGTATC CACGTGGTGGCCGAGCTCTTCTAGAATCTGGTAGCTCTAGCTAATTTCAGAGAAAGGAGTTAAAAGAAACAACTTAACAACC

GATA3.F2 (forward primer)
GATA3.R5 (reverse primer)
Single exon skipping

Frame 0

EH*AAWRRLDTFRKNAFPVKKKKKY*ERERERE EERETEGERDRASNAI*PSRSYAAASSSSLLFAT QVTRGGTPPPSG*GPRCRGAWLAELQSRRPFLQ PGPVLFCRTQFLDFCLPLLLFAKRPLQDNF*KT FSFAHLCFPAFPSPHRKQIIQRPPTLRRQEPPDL PGGPPSLPARGFRARREGASTAEAMEVTADQPR WVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYP LPEEVDVLFNIDGQGNHVPPYYGNSVRATVQRYP PTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTA SPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLS GGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSA RQDEKECLKYQVPLPDSMKLESSHSRGSMTALG GASSSTHHPITTYPPYVPEYSSGLFPPSSLLGG SPTGFGCKSRPKARSSTEGRECVNCGATSTPLWR RDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLS AARRAGTSCANCQTTTTTLWRRNANGDPVCNAC GLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKC KKVHDSLEDFPKNSSFNPAALSRHMSSLSHISP FSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTA MG*SPARCSQGPQRESLQSLSTCIFAGAVS*SLN AMDICF*RQKAKLCLPLCKGAHCGVCVPTTESG PHL*ISHSDSYPLFNRVSSAVKKKMLNIAYNLY CKKYCTMTLLHLGSCKA*RMPRSLRNMGEIVWKL RRN*V*YSNGQTASFVSFHWPQLFDALKENKKK KKEKRKKKKKVVGESFVQSCWPLQRKYQFWAIS VTVHQLPLRVSESLFLGLHAL*TSPCNCCLYV*F KAPK*EKM*IYFIILYRPNCCINLFTASLKNCF LSFVCFNIFLLSQFLVE*TRLHSVGLRWLCSEG FLFLFHFVFG*YLLNSF*ESGGICLVPIPAACAE GSSV*ATSVHVSDPGPTGHVLQSARLPLRPVVF CVSDHCL*YSLLE*YYKHNNKVKIF*NYKMTSY PRGGRALLESGSSS*FQRKELKETT*Q

Frame 1

NTELPGAVLILSERMHSL*KKKKNTERGREREK KRERRRESETERATQSDRAGRTPPPPPPLCSSL PR*PEEGLRLRAAEDPGAEEPGSQNCRVVAPFYN LVPFYSAVPSFWIFVFPFFSLLNDPSKIIFKKP SPLLTFASQPSHPPTESKSFNDPRPSDGRSPPT SQADRPPSPRAGSGPGERARAQPRPWR*RRTSRA G*ATTTPPCSTGSTRTRTTRASATPTWTRRSTR CRRRWMCFLTSTVKATTSRPTTETRSGPRCRGT LRPTTGARCAARLCFMDPYPGWTAAKPWAATTPP PPGISAPSPRRPSTTAPRGPSPSTPRPRPPPCR GATPARTSSPSRPPRRRTSPRTHRCPPQARPAR PGRTRKSASSTRCPCPTA*SWSRPTPVAA*PPWV EPPRRPTTPSPPTRPTCPSTAPDSSPPAACWAA PPPASDASPGPRPGPAQKAGSV*TVGQPRPHCG GEMARDTTCATPAGSITK*TDRTGPSLSPSEGCL QPGEQGRPVRTVRPPQPHSGGGMPMGTLSAMPV GSTTSFTILTDP*L*RRKASRPETEKCLANPKS AKKCMTHWRTSPRTARLTRPPSPDTCPP*ATSRP SATPATC*PRPRRCTRHPACPLDHTTPPAWSPP WVRALLDAHRAPSESPCSPFRLAFLQEQYHEA* TRWIYVFEGRKQNYVCHFAKELTVVSVFQPLNLD PICE*AILTHIPYLTGSLVL*KKKC*TLHITYI VRNTVQ*LYCIWVAVRHEGCQEV*GIWEK*CGN *EETRSDIQMDKLPVLFPFTGHSCLMH*KKIKKR KKRKEKKRKKL*ANHLFKAVGLCKGNTSSGQSV LPFTSCR*GFQRAFF*AYMLCEQVPVIVVCMYN SKHQNKKRCRFISSYYTDRTVV*IYLLLVLRTAF FRLFVSIFSFSLNFWLNKLDYIQLA*GGCARRV SCFFSILFLDDIY*IASKSPAASVLSLFLQPVL RVAVYELPACMSATLARQATSCNRPGCLFALSCS VLVITAFNTVCWNNIISIIIK*KYFKTTK*HRI HVVAELF*NLVALANFRERS*KKQLNN

Frame 2

TLSCLAPS*YFQKECIPCKKKKKILREGERERR RERDGGRARQSEQRNLTEQVVRRRLLLLSALRY PGDPRRDSASERLRTPVQRSLARRIAESSPLFT TWSRFILPYPVFGFLSSPSSLC*TTPPR*FLKNL LLCSPLLPSLPIPPPKANHSTTPDPPTAGAPRP PRRTALPPRARVPGPARGREHSRGHGGDGGPAA LGEPPPPRRAQRAAPGHAPPGPQPLLHGRGAVPA AGGGGCAF*HRRSRQPRPALLRKLGQGHGAEVP SDPPREPGVPPASASWIPTLAGRRQSPGQPPHR LPLESQPLLQDVHPPRLPGAPLRLPPGLVLLLVG GPRQPAPLHLPAHPAEGRLPGPIAVHPRLGRLG PAGRERVPQVPGAPARQHEAGVVPLPWQHDRPG WSLLVDPPPHHHLPALRARVQLRTLPPQQPAGRL PHRLRMQVQAQGPVQHRRQGVCELWGNLDPTVA ARWHGTLPVQRLRALSQNERTEPAPH*AQAKAV CSQESRDVLCELSDHHNHTLEEECQWGPCLQCLW ALLQASQY*QTPDYEEGRHPDQKPKNV*QIQKV QKSA*LTGGLPQEQLV*PGRPLQTHVLPEPHLA LQPLQPHADHAHADAPAIQPVLWTTPPLQHGHRH GLEPCSMLTGPPARVPAVPFDLHFCRSSIMKPK RDGYMFLKAESKIMFATLQRSSLWCLCSNH*IW TPSVNKPF*LISPI*QGL*CCEKKNAEHCI*LIL *EILYNDFIASG*L*GMKDAKKFKEYGRNSVEI KKKLGLIFKWTNCQFCFLSLATVV*CIKRK*KK EKREKKKKEKSCRRIICSKLLASAKEIPVLGNQC YRSPVAVEGFREPFSRPTCFVNKSL*LLFVCII QSTKIRKDVDLFHHIIQTELLYKFIYC*S*ELL SFVCLFQYFPSLSIFG*IN*ITFSWPKVVVLGGF LVSFPFCFWMIFIK*LLRVRRHLSCPYSCSLC* G*QCMSYQRACQRPWPDRPRPAIGPAASSPCRV LC**SLPLIQSVGIIL*A***SENILKLQNDIVS TWWPSSSRIW*L*LISEKGVKRNNLTT