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Sequences

Sequence NRG1.aAug05

GTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGAGGAGTTCCCCGAAACTTGTTGGAA
CTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAGGACGGTGATAACCTCTCCCCGATCGGGTTGCGAG
GGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTTCCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCG
TTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCT
CTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGC
GAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCC
CAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCT
CAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATT
AACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAA
ACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTC
TTCATCTACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTG
AAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAAGGCGG
AGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATCATGTGTGTGGTGGCCTACTGCAAAACCAAGAA
ACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAATATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCC
CCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTC
ACTATACTTCCACAGCCCATCACTCCACTACTGTCACCCAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTC
TGTAATCGTGATGTCATCCGTAGAAAACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAAC
AGCTTCCTCAGGCATGCCAGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCAC
CTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCGGTCAG
CCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCTCAGCAGTTCAGCTCCTTCCAC
CACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACGACCCAAGAGTACGAGCCAGCCCAAG
AGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCTAACAGATTGGAAGTGGACAGCAACACAAGCTCCCA
GAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCTTTCCTGGGCATACAGAACCCCCTGGCAGCCAGTCTTGAGGCAACA
CCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGCTTCTCGACACAGGAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAAG
ACCCTATTGCTGTATAAAACCTAAATAAACACATAGATTCACCTGTAAAACTTTATTTTATATAATAAAGTATTCCACCTTAAATTAAACAATTTATTTT
ATTTTAGCAGTTCTGCAAATAGAAAACAGGAAAAAAACTTTTATAAATTAAATATATGTATGTAAAAATGTGTTATGTGCCATATGTAGCAATTTTTTAC
AGTATTTCAAAACGAGAAAGATATCAATGGTGCCTTTATGTTATGTTATGTCGAGAGCAAGTTTTGTACAGTTACAGTGATTGCTTTTCCACAGTATTTC
TGCAAAACCTCTCATAGATTCAGTTTTTGCTGGCTTCTTGTGCATTGCATTATGATGTTGACTGGATGTATGATTTGCAAGACTTGCAACTGTCCCTCTG
TTTGCTTGTAGTAGCACCCGATCAGTATGTCTTGTAATGGCACATCCATCCAGATATGCCTCTCTTGTGTATGAAGTTTTCTTTGCTTTCAGAATATGAA
ATGAGTTGTGTCTACTCTGCCAGCCAAAGGTTTGCCTCATTGGGCTCTGAGATAATAGTAGATCCAACAGCATGCTACTATTAAATACAGCAAGAAACTG
CATTAAGTAATGTTAAATATTAGGAAGAAAGTAATACTGTGATTTAAAAAAAACTATATTATTAATCAGAAGACAGCTTGCTCTTACTAAAAGGAGCTCT
CATTTACTTTATTTGATTTTATTTTTCTTGACAAAAAGCAACAGTTTTAGGGATAGCTTAGAAAATGGGTTCTGGCT
  • NRG1.u.f.21 (forward primer)
  • NRG1.u.r.25 (reverse primer)
  • Single exon skipping

Frame 0

VRRRRLPPTCGREVGGCGAIEKEPARSSPKLVG
TPGSRGGQELSGGGCRTMGA*AGR**PLPDRVAR
APGRGQDASRQRWDPSTTSRGDRSSPESQGERP
FQVAGPPAASAPRSLQATGDAPAQRERLSAAAR
SPPRGTNFSQTRSEPLDQTRLRREPSA*SAPSPA
RCPSAKKAEAKGRARRRSEAPARSRSPRRAARA
QPCLPD*KR*KARNRLQVPN*SFGVKPVLNTPL
SDSSGSRMGMN*IEKTNHKISRYKKSQGSQNFAL
TKHHWLILESICAK*SAN*EMTVPLPISPSWNQ
TRSSLVCQPQLKEHMCLQSLPLEYQYPQKEQIL
LHLHLHPPLGQAIL*NVRRRRKLSV*MEGSASW*
KTFQTPRDTCASAQMSLLVIAAKTT*WPASTRR
RSCTRREC*P*PASASPSLWSASCVWWPTAKPR
NSGKSCMTVFGRAFGLNETI**TLPMGLTILTHP
PRMSSW*INTYLKTSSPVSILLREKQRHPFPPV
TILPQPITPLLSPRLLATAGATDTLKASFPKAT
L*S*CHP*KTVGTAAQLGAQEDVLMAQEALVNVT
ASSGMPEKPLIPTETLLIVKGMCQP*PPRLVCH
L*ISTRQAPPNRPLRKCLHPCPA*RCPCLPWRS
APSWKKRDLYFS*HHQGCGRRSLTITLSSSAPST
TTPRMTVTASLLAP*G*WRMRSMKRPKSTSQPK
SLLRNSPIAGGPKEPSPMATLLTDWKWTATQAP
RAVTQRVKQKMKE*VKIRLSWAYRTPWQPVLRQH
LPSAWLTAGLTQQAASRHRKKSRPGCLV*LLTK
TLLLYKT*INT*IHL*NFILYNKVFHLKLNNLF
YFSSSANRKQEKNFYKLNICM*KCVMCHM*QFFT
VFQNEKDINGAFMLCYVESKFCTVTVIAFPQYF
CKTSHRFSFCWLLVHCIMMLTGCMICKTCNCPS
VCL**HPISMSCNGTSIQICLSCV*SFLCFQNMK
*VVSTLPAKGLPHWALR***IQQHATIKYSKKL
H*VMLNIRKKVIL*FKKNYIINQKTACSY*KEL
SFTLFDFIFLDKKQQF*G*LRKWVLA

Frame 1

CEGGACLQPAGGRWVAAGQLKKSRRGVPRNLLE
LRARAEARS*AAAAAGRWEREQDGDNLSPIGLR
GRRAEARTRAASGGTHRRLPGATGAAPRARASAR
SRWPDRPPRPRRAPCRQRETPPRSASASARPLA
LPLEGQTFPKPDPSPWTKLACAESRPRRALRLR
RDVRAQRRQRQREGQEEGARLRQEAGVRGGQPEP
SLASPIERDEKPGIGCRFQTSPSV*NQF*ILLS
QIQVVQEWE*IESKKQTTKYQDTKKAREVRTSH
*QSITG*FWRVYVQSDQQIRK*QCLCQYHHRGIK
RDHHWYASLN*RSICVFRVSH*NISIHRRSKYF
FIYIYIHHWDKPSCKMCGEGENFLCEWRGVLHG
ERPFKPLEILVQVPK*VYW*SLPKLRNGQLLQGG
GAVPEESADHNRHLHRPPCGRHHVCGGLLQNQE
TAEKAA*PSSAEPSV*TKQYDEHCQWASPS*PT
PRECPAGESIRI*KRHLQ*AYC*ERSRDILFHQS
LYFHSPSLHYCHPDS*PQLEQRTH*KHPFRKPL
CNRDVIRRKQ*AQQPNWGPKRTS*WHRRPS*M*
QLPQACQRNP*FLPRLSS**KVCVSHDHPGSYVT
CRFPHAKLPQIAPFGNVSTRVQHDGVHAFHGGQ
PLHGRRETSTSRDTTKAAGEEV*PSPSAVQLLP
PQPRA*Q*QPPC*PLEDSGG*GV*NDPRVRASPR
AC*ETRQ*PAGQKNQAQWPHC*QIGSGQQHKLP
EQ*LRE*NRR*KSR*RYAFPGHTEPPGSQS*GN
TCLPPG*QQD*PSRPLLDTGRNPGQAV*CNC*PR
PYCCIKPK*THRFTCKTLFYIIKYSTLN*TIYF
ILAVLQIENRKKTFIN*IYVCKNVLCAICSNFL
QYFKTRKISMVPLCYVMSRASFVQLQ*LLFHSIS
AKPLIDSVFAGFLCIAL*C*LDV*FARLATVPL
FACSSTRSVCLVMAHPSRYASLVYEVFFAFRI*
NELCLLCQPKVCLIGL*DNSRSNSMLLLNTARNC
IK*C*ILGRK*YCDLKKTILLIRRQLALTKRSS
HLLYLILFFLTKSNSFRDSLENGFW

Frame 2

AKEAPASNLRAGGGWLRGN*KRAGEEFPETCWN
SGLARRPGAERRRLPDDGSVSRTVITSPRSGCE
GAGQRPGREPPAVGPIDDFPGRQEQPREPGRAP
VPGGRTARRVRAALPAGNGRRPRAARAPQRGRSL
SPSRDKLFPNPIRALGPNSPAPRAVRVERSVSG
EMSERKEGRGKGKGKKKERGSGKKPESAAGSQS
PALPPRLKEMKSQESAAGSKLVLRCETSSEYSSL
RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI
NKASLADSGEYMCKVISKLGNDSASANITIVES
NEIITGMPASTEGAYVSSESPIRISVSTEGANTS
SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKA
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKK
QRKKLHDRLRQSLRSERNNMMNIANGPHHPNPP
PENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHS
VIVMSSVENSRHSSPTGGPRGRLNGTGGPRECN
SFLRHARETPDSYRDSPHSERYVSAMTTPARMS
PVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVS
PFMEEERPLLLVTPPRLREKKFDHHPQQFSSFH
HNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ
EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQ
SSNSESETEDERVGEDTPFLGIQNPLAASLEAT
PAFRLADSRTNPAGRFSTQEEIQARLSSVIANQ
DPIAV*NLNKHIDSPVKLYFI**SIPP*IKQFIL
F*QFCK*KTGKKLL*IKYMYVKMCYVPYVAIFY
SISKRERYQWCLYVMLCREQVLYSYSDCFSTVF
LQNLS*IQFLLASCALHYDVDWMYDLQDLQLSLC
LLVVAPDQYVL*WHIHPDMPLLCMKFSLLSEYE
MSCVYSASQRFASLGSEIIVDPTACYY*IQQET
ALSNVKY*EESNTVI*KKLYY*SEDSLLLLKGAL
IYFI*FYFS*QKATVLGIA*KMGSG

Sequence NRG1.cAug05

GTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGAGGAGTTCCCCGAAACTTGTTGGAA
CTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAGGACGGTGATAACCTCTCCCCGATCGGGTTGCGAG
GGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTTCCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCG
TTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCT
CTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGC
GAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCC
CAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCT
CAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATT
AACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAA
ACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTC
TTCATCTACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTG
AAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAAGCATC
TTGGGATTGAATTTATGGAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATCATGTGTGT
GGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAATATGATGAACATTGCCAAT
GGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATCTCCAGTGAGCATATTGTTGAGAGAGAAG
CAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTCACCCAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGA
AAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAAAACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGC
ACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCCAGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCA
TGACCACCCCGGCTCGTATGTCACCTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGT
GTCCATGCCTTCCATGGCGGTCAGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCAC
CCTCAGCAGTTCAGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACGA
CCCAAGAGTACGAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCTAACAGATTGGA
AGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCTTTCCTGGGCATACAGAACCCC
CTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGCTTCTCGACACAGGAAGAAATCCAGGCCAGGC
TGTCTAGTGTAATTGCTAACCAAGACCCTATTGCTGTATAAAACCTAAATAAACACATAGATTCACCTGTAAAACTTTATTTTATATAATAAAGTATTCC
ACCTTAAATTAAACAATTTATTTTATTTTAGCAGTTCTGCAAATAGAAAACAGGAAAAAAACTTTTATAAATTAAATATATGTATGTAAAAATGTGTTAT
GTGCCATATGTAGCAATTTTTTACAGTATTTCAAAACGAGAAAGATATCAATGGTGCCTTTATGTTATGTTATGTCGAGAGCAAGTTTTGTACAGTTACA
GTGATTGCTTTTCCACAGTATTTCTGCAAAACCTCTCATAGATTCAGTTTTTGCTGGCTTCTTGTGCATTGCATTATGATGTTGACTGGATGTATGATTT
GCAAGACTTGCAACTGTCCCTCTGTTTGCTTGTAGTAGCACCCGATCAGTATGTCTTGTAATGGCACATCCATCCAGATATGCCTCTCTTGTGTATGAAG
TTTTCTTTGCTTTCAGAATATGAAATGAGTTGTGTCTACTCTGCCAGCCAAAGGTTTGCCTCATTGGGCTCTGAGATAATAGTAGATCCAACAGCATGCT
ACTATTAAATACAGCAAGAAACTGCATTAAGTAATGTTAAATATTAGGAAGAAAGTAATACTGTGATTTAAAAAAAACTATATTATTAATCAGAAGACAG
CTTGCTCTTACTAAAAGGAGCTCTCATTTACTTTATTTGATTTTATTTTTCTTGACAAAAAGCAACAGTTTTAGGGATAGCTTAGAAAATGGGTTCTGGC
T
  • NRG1.u.f.21 (forward primer)
  • NRG1.u.r.25 (reverse primer)
  • Single exon skipping

Frame 0

VRRRRLPPTCGREVGGCGAIEKEPARSSPKLVG
TPGSRGGQELSGGGCRTMGA*AGR**PLPDRVAR
APGRGQDASRQRWDPSTTSRGDRSSPESQGERP
FQVAGPPAASAPRSLQATGDAPAQRERLSAAAR
SPPRGTNFSQTRSEPLDQTRLRREPSA*SAPSPA
RCPSAKKAEAKGRARRRSEAPARSRSPRRAARA
QPCLPD*KR*KARNRLQVPN*SFGVKPVLNTPL
SDSSGSRMGMN*IEKTNHKISRYKKSQGSQNFAL
TKHHWLILESICAK*SAN*EMTVPLPISPSWNQ
TRSSLVCQPQLKEHMCLQSLPLEYQYPQKEQIL
LHLHLHPPLGQAIL*NVRRRRKLSV*MEGSASW*
KTFQTPRDTCASAQMSLLVIAAKTT*WPASTSI
LGLNLWRRRSCTRREC*P*PASASPSLWSASCV
WWPTAKPRNSGKSCMTVFGRAFGLNETI**TLPM
GLTILTHPPRMSSW*INTYLKTSSPVSILLREK
QRHPFPPVTILPQPITPLLSPRLLATAGATDTL
KASFPKATL*S*CHP*KTVGTAAQLGAQEDVLMA
QEALVNVTASSGMPEKPLIPTETLLIVKGMCQP
*PPRLVCHL*ISTRQAPPNRPLRKCLHPCPA*R
CPCLPWRSAPSWKKRDLYFS*HHQGCGRRSLTIT
LSSSAPSTTTPRMTVTASLLAP*G*WRMRSMKR
PKSTSQPKSLLRNSPIAGGPKEPSPMATLLTDW
KWTATQAPRAVTQRVKQKMKE*VKIRLSWAYRTP
WQPVLRQHLPSAWLTAGLTQQAASRHRKKSRPG
CLV*LLTKTLLLYKT*INT*IHL*NFILYNKVF
HLKLNNLFYFSSSANRKQEKNFYKLNICM*KCVM
CHM*QFFTVFQNEKDINGAFMLCYVESKFCTVT
VIAFPQYFCKTSHRFSFCWLLVHCIMMLTGCMI
CKTCNCPSVCL**HPISMSCNGTSIQICLSCV*S
FLCFQNMK*VVSTLPAKGLPHWALR***IQQHA
TIKYSKKLH*VMLNIRKKVIL*FKKNYIINQKT
ACSY*KELSFTLFDFIFLDKKQQF*G*LRKWVLA

Frame 1

CEGGACLQPAGGRWVAAGQLKKSRRGVPRNLLE
LRARAEARS*AAAAAGRWEREQDGDNLSPIGLR
GRRAEARTRAASGGTHRRLPGATGAAPRARASAR
SRWPDRPPRPRRAPCRQRETPPRSASASARPLA
LPLEGQTFPKPDPSPWTKLACAESRPRRALRLR
RDVRAQRRQRQREGQEEGARLRQEAGVRGGQPEP
SLASPIERDEKPGIGCRFQTSPSV*NQF*ILLS
QIQVVQEWE*IESKKQTTKYQDTKKAREVRTSH
*QSITG*FWRVYVQSDQQIRK*QCLCQYHHRGIK
RDHHWYASLN*RSICVFRVSH*NISIHRRSKYF
FIYIYIHHWDKPSCKMCGEGENFLCEWRGVLHG
ERPFKPLEILVQVPK*VYW*SLPKLRNGQLLQAS
WD*IYGGGGAVPEESADHNRHLHRPPCGRHHVC
GGLLQNQETAEKAA*PSSAEPSV*TKQYDEHCQ
WASPS*PTPRECPAGESIRI*KRHLQ*AYC*ERS
RDILFHQSLYFHSPSLHYCHPDS*PQLEQRTH*
KHPFRKPLCNRDVIRRKQ*AQQPNWGPKRTS*W
HRRPS*M*QLPQACQRNP*FLPRLSS**KVCVSH
DHPGSYVTCRFPHAKLPQIAPFGNVSTRVQHDG
VHAFHGGQPLHGRRETSTSRDTTKAAGEEV*PS
PSAVQLLPPQPRA*Q*QPPC*PLEDSGG*GV*ND
PRVRASPRAC*ETRQ*PAGQKNQAQWPHC*QIG
SGQQHKLPEQ*LRE*NRR*KSR*RYAFPGHTEP
PGSQS*GNTCLPPG*QQD*PSRPLLDTGRNPGQA
V*CNC*PRPYCCIKPK*THRFTCKTLFYIIKYS
TLN*TIYFILAVLQIENRKKTFIN*IYVCKNVL
CAICSNFLQYFKTRKISMVPLCYVMSRASFVQLQ
*LLFHSISAKPLIDSVFAGFLCIAL*C*LDV*F
ARLATVPLFACSSTRSVCLVMAHPSRYASLVYE
VFFAFRI*NELCLLCQPKVCLIGL*DNSRSNSML
LLNTARNCIK*C*ILGRK*YCDLKKTILLIRRQ
LALTKRSSHLLYLILFFLTKSNSFRDSLENGFW

Frame 2

AKEAPASNLRAGGGWLRGN*KRAGEEFPETCWN
SGLARRPGAERRRLPDDGSVSRTVITSPRSGCE
GAGQRPGREPPAVGPIDDFPGRQEQPREPGRAP
VPGGRTARRVRAALPAGNGRRPRAARAPQRGRSL
SPSRDKLFPNPIRALGPNSPAPRAVRVERSVSG
EMSERKEGRGKGKGKKKERGSGKKPESAAGSQS
PALPPRLKEMKSQESAAGSKLVLRCETSSEYSSL
RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI
NKASLADSGEYMCKVISKLGNDSASANITIVES
NEIITGMPASTEGAYVSSESPIRISVSTEGANTS
SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKH
LGIEFMEAEELYQKRVLTITGICIALLVVGIMCV
VAYCKTKKQRKKLHDRLRQSLRSERNNMMNIAN
GPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTE
SILSESHSVIVMSSVENSRHSSPTGGPRGRLNG
TGGPRECNSFLRHARETPDSYRDSPHSERYVSA
MTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTV
SMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYET
TQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLE
VDSNTSSQSSNSESETEDERVGEDTPFLGIQNP
LAASLEATPAFRLADSRTNPAGRFSTQEEIQAR
LSSVIANQDPIAV*NLNKHIDSPVKLYFI**SIP
P*IKQFILF*QFCK*KTGKKLL*IKYMYVKMCY
VPYVAIFYSISKRERYQWCLYVMLCREQVLYSY
SDCFSTVFLQNLS*IQFLLASCALHYDVDWMYDL
QDLQLSLCLLVVAPDQYVL*WHIHPDMPLLCMK
FSLLSEYEMSCVYSASQRFASLGSEIIVDPTAC
YY*IQQETALSNVKY*EESNTVI*KKLYY*SEDS
LLLLKGALIYFI*FYFS*QKATVLGIA*KMGSG

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