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Sequences

Sequence TOPBP1.dAug05

GAGAGACTGTATCTGAAACAATTACTTTGTTTTAGAGACATGTTATTGAACTAGGTGAACAATTAGTGTAATTCTGTTTTGGTGGTTCTCCTTTGTAAAA AAAAGATTATAAATCCTAAAAAATGAGGGAAGCAATAGTGATATTTGTGTTGTTTTTCATTATTCTTCTGGTAAATTTAATATGTTCTTTTTTAACCATT TGATTCCCACAGAAAAATAACTAGATATACTGATATAAACATGGAAGATTTCAAGTGTCCTATTTTTCTTGGTTGCATAATCTGTGTGACTGGCTTATGT GGCTTAGACAGGAAAGAAGTTCAGCAACTCACAGTTAAGCATGGAGGTCAATACATGGGACAATTGAAAATGAATGAATGTACACACCTCATTGTGCAAG AACCAAAAGGTCAGAAGTATGAGTGTGCCAAGAGATGGAATGTACACTGTGTGACCACACAGTGGTTTTTTGACAGTATTGAGAAAGGTTTTTGTCAGGA TGAATCCATATACAAGACAGAACCTAGACCAGAAGCAAAGACTATGCCCAATTCTTCAACTCCTACCAGCCAGATCAACACAATTGATAATGTCAGCAAT ATTTCCAACATAAATGCAAGTTGCGTAAGTGAATCAATATGTAATTCACTTAACAGCAAACTGGAGCCTACACTTGAAAATCTAGAAAATCTGGATGTCA GTGCATTTCAAGCACCTGAAGATTTATTAGATGGTTGTCGGATATATCTTTGCGGTTTTAGTGGCAGAAAGCTAGATAAACTGAGAAGACTTATTAACAG TGGAGGTGGAGTTCGTTTTAACCAGCTAAATGAAGATGTAACTCATGTTATTGTGGGAGATTATGATGATGAATTGAAGCAGTTTTGGAATAAATCAGCC CACAGGCCTCATGTAGTGGGAGCAAAGTGGTTGCTAGAGTGTTTCAGTAAAGGTTATATGCTTTCTGAAGAACCATATATCCATGCTAATTACCAGCCAG TGGAAATTCCAGTTTCACATAAGCCTGAAAGTAAAGCAGCTCTTTTAAAAAAGAAGAACAGCAGCTTCTCTAAGAAAGACTTTGCTCCTAGTGAAAAGCA TGAGCAAGCTGATGAA

TOPBP1.u.f.8 (forward primer)
TOPBP1.u.r.8 (reverse primer)
Alternative acceptor

Frame 0

ERLYLKQLLCFRDMLLN*VNN*CNSVLVVLLCK KKIINPKK*GKQ**YLCCFSLFFW*I*YVLF*PF DSHRKITRYTDINMEDFKCPIFLGCIICVTGLC GLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQ EPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQD ESIYKTEPRPEAKTMPNSSTPTSQINTIDNVSN ISNINASCVSESICNSLNSKLEPTLENLENLDV SAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINS GGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSA HRPHVVGAKWLLECFSKGYMLSEEPYIHANYQP VEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKH EQADE

Frame 1

RDCI*NNYFVLETCY*TR*TISVILFWWFSFVK KRL*ILKNEGSNSDICVVFHYSSGKFNMFFFNH LIPTEK*LDILI*TWKISSVLFFLVA*SV*LAYV A*TGKKFSNSQLSMEVNTWDN*K*MNVHTSLCK NQKVRSMSVPRDGMYTV*PHSGFLTVLRKVFVR MNPYTRQNLDQKQRLCPILQLLPARSTQLIMSAI FPT*MQVA*VNQYVIHLTANWSLHLKI*KIWMS VHFKHLKIY*MVVGYIFAVLVAES*IN*EDLLT VEVEFVLTS*MKM*LMLLWEIMMMN*SSFGINQP TGLM*WEQSGC*SVSVKVICFLKNHISMLITSQ WKFQFHISLKVKQLF*KRRTAASLRKTLLLVKS MSKLM

Frame 2

ETVSETITLF*RHVIELGEQLV*FCFGGSPL*K KDYKS*KMREAIVIFVLFFIILLVNLICSFLTI *FPQKNN*IY*YKHGRFQVSYFSWLHNLCDWLM WLRQERSSATHS*AWRSIHGTIENE*MYTPHCAR TKRSEV*VCQEMECTLCDHTVVF*QY*ERFLSG *IHIQDRT*TRSKDYAQFFNSYQPDQHN**CQQ YFQHKCKLRK*INM*FT*QQTGAYT*KSRKSGCQ CISST*RFIRWLSDISLRF*WQKAR*TEKTY*Q WRWSSF*PAK*RCNSCYCGRL***IEAVLE*IS PQASCSGSKVVARVFQ*RLYAF*RTIYPC*LPAS GNSSFT*A*K*SSSFKKEEQQLL*ERLCS**KA *AS**

Sequence TOPBP1.aAug05

TGGGGTAGGGGCGGCGCCGAGTCGGGGGAGGGGGCTGTGCGCCGGGCTGGCGCCCGACCCCAGCCACCGCCCTGCGGCCAGCGCGTCCCCCGACTCGCCG CCCGGAGACCCCGAGGCTCCAACGAGTTCAGAAATGTCCAGAAATGACAAAGAACCGTTTTTTGTGAAGTTTTTAAAGTCTTCAGACAATTCCAAATGTT TTTTTAAAGCTCTCGAGTCCATAAAAGAATTCCAATCAGAAGAATATCTTCAGATTATTACAGAAGAAGAGGCATTGAAGATAAAGGAGAATGATAGATC ACTTTATATCTGTGACCCTTTTAGTGGCGTTGTCTTTGATCACCTCAAAAAGCTTGGCTGCAGAATTGTTGGTCCTCAAGTAGTCATATTTTGTATGCAC CACCAGCGATGTGTCCCAAGAGCCGAACATCCAGTTTATAATATGGTTATGTCTGATGTAACCATATCTTGTACAAGTCTGGAAAAAGAAAAAAGGGAAG AAGTTCATAAATATGTACAAATGATGGGCGGACGAGTATACAGAGACCTTAATGTATCAGTAACTCACCTTATTGCAGGAGAAGTTGGTAGCAAAAAATA TTTAGTTGCTGCAAACCTGAAGAAACCTATTTTGCTTCCCTCTTGGATAAAAACACTTTGGGAGAAGTCACAAGAGAAAAAAATAACTAGATATACTGAT ATAAACATGGAAGATTTCAAGTGTCCTATTTTTCTTGGTTGCATAATCTGTGTGACTGGCTTATGTGGCTTAGACAGGAAAGAAGTTCAGCAACTCACAG TTAAGCATGGAGGTCAATACATGGGACAATTGAAAATGAATGAATGTACACACCTCATTGTGCAAGAACCAAAAGGTCAGAAGTATGAGTGTGCCAAGAG ATGGAATGTACACTGTGTGACCACACAGTGGTTTTTTGACAGTATTGAGAAAGGTTTTTGTCAGGATGAATCCATATACAAGACAGAACCTAGACCAGAA GCAAAGACTATGCCCAATTCTTCAACTCCTACCAGCCAGATCAACACAATTGATAGTCGTACTCTTTCAGATGTCAGCAATATTTCCAACATAAATGCAA GTTGCGTAAGTGAATCAATATGTAATTCACTTAACAGCAAACTGGAGCCTACACTTGAAAATCTAGAAAATCTGGATGTCAGTGCATTTCAAGCACCTGA AGATTTATTAGATGGTTGTCGGATATATCTTTGCGGTTTTAGTGGCAGAAAGCTAGATAAACTGAGAAGACTTATTAACAGTGGAGGTGGAGTTCGTTTT AACCAGCTAAATGAAGATGTAACTCATGTTATTGTGGGAGATTATGATGATGAATTGAAGCAGTTTTGGAATAAATCAGCCCACAGGCCTCATGTAGTGG GAGCAAAGTGGTTGCTAGAGTGTTTCAGTAAAGGTTATATGCTTTCTGAAGAACCATATATCCATGCTAATTACCAGCCAGTGGAAATTCCAGTTTCACA TAAGCCTGAAAGTAAAGCAGCTCTTTTAAAAAAGAAGAACAGCAGCTTCTCTAAGAAAGACTTTGCTCCTAGTGAAAAGCATGAGCAAGCTGATGAAGAT CTGCTCTCTCAATATGAAAATGGTAGCTCCACAGTAGTTGAGGCTAAGACGTCTGAAGCCAGGCCCTTTAATGATTCTACTCATGCTGAGCCCTTGAATG ATTCTACTCACATTTCTTTGCAAGAAGAAAACCAGTCTTCTGTCAGTCATTGTGTCCCTGATGTTTCTACAATTACTGAAGAAGGCTTATTTAGCCAAAA GAGTTTCCTTGTTTTGGGTTTTAGTAATGAAAATGAATCTAACATCGCAAACATCATAAAAGAAAATGCTGGGAAAATCATGTCCCTTCTGAGCAGAACT GTTGCGGATTATGCTGTGGTTCCTCTGCTGGGGTGTGAAGTGGAAGCCACTGTGGGAGAAGTTGTTACAAATACATGGCTGGTTACTTGCATAGACTATC AGACTTTGTTTGATCCAAAGTCGAATCCTCTCTTCACACCAGTTCCAGTAATGACAGGAATGACTCCTTTAGAGGATTGTGTTATTTCATTTAGCCAGTG TGCTGGAGCAGAAAAAGAGTCTTTAACATTCCTAGCAAACCTCCTTGGAGCAAGTGTTCAAGAATACTTTGTTCGCAAATCCAATGCAAAGAAAGGCATG TTTGCCAGTACTCATCTTATACTGAAAGAACGTGGTGGCTCTAAATATGAAGCTGCAAAGAAGTGGAATTTACCTGCCGTTACTATAGCTTGGCTGTTGG AGACTGCTAGAACGGGAAAGAGAGCAGACGAAAGCCATTTTCTGATTGAAAATTCAACTAAAGAAGAACGAAGTTTGGAAACAGAAATAACAAATGGAAT CAATCTAAATTCAGATACTGCAGAGCATCCTGGCACACGCCTGCAAACTCACAGAAAAACCGTCGTTACACCTTTAGATATGAACCGCTTTCAGAGTAAA GCTTTCCGTGCTGTGGTCTCACAACATGCCAGACAGGTCGCAGCCTCCCCAGCAGTAGGACAACCACTTCAGAAGGAGCCCTCGTTACACCTGGATACAC CATCAAAATTCCTGTCCAAGGACAAACTCTTCAAGCCTTCCTTTGATGTGAAGGATGCACTTGCAGCCTTGGAAACTCCAGGACGTCCCAGCCAACAGAA AAGGAAACCGAGTACGCCACTCTCAGAAGTTATTGTCAAAAACTTGCAACTTGCTTTGGCAAATAGCTCTCGAAATGCTGTCGCTCTTTCTGCCAGCCCT CAACTGAAAGAGGCCCAGTCAGAGAAGGAAGAAGCCCCAAAGCCACTTCACAAAGTAGTGGTATGTGTTAGTAAAAAACTCAGTAAGAAGCAGAGTGAAC TAAATGGGATCGCAGCCTCTCTAGGAGCAGATTACAGGTGGAGTTTTGATGAAACAGTGACTCATTTCATCTATCAAGGGCGGCCAAATGACACTAATCG GGAGTATAAATCTGTAAAAGAAAGAGGAGTACACATTGTTTCCGAGCACTGGCTTTTAGATTGTGCCCAAGAGTGTAAACATCTTCCTGAATCTCTTTAT CCACATACTTATAATCCCAAAATGAGCTTGGATATCAGCGCAGTGCAAGATGGCCGGCTCTGTAATAGTCGACTACTCTCAGCTGTGTCTTCAACAAAGG ATGATGAGCCAGATCCTTTGATTTTAGAAGAAAATGATGTAGACAATATGGCCACCAATAATAAAGAGTCAGCACCATCAAATGGAAGTGGAAAGAATGA CTCTAAAGGAGTTCTGACACAGACCTTAGAGATGAGAGAGAACTTTCAGAAGCAGTTACAGGAGATAATGTCTGCAACATCAATAGTGAAACCCCAAGGG CAGAGGACTTCCCTTTCAAGAAGTGGTTGTAACAGCGCATCTTCAACCCCTGACAGCACTCGCTCTGCTCGCAGTGGACGAAGTAGAGTCCTAGAGGCAC TGAGGCAGTCTCGTCAGACAGTACCTGATGTCAACACAGAGCCTTCCCAAAATGAACAGATCATTTGGGATGACCCTACAGCAAGGGAGGAGAGAGCAAG GCTTGCCAGCAATTTGCAGTGGCCTAGTTGTCCCACACAATACTCTGAGCTTCAGGTTGACATTCAAAACTTGGAGGATTCTCCTTTTCAAAAGCCTTTA CATGATTCAGAAATTGCTAAACAGGCTGTCTGTGATCCTGGAAACATACGTGTGACTGAAGCTCCCAAACACCCAATCTCTGAAGAACTGGAAACTCCCA TAAAAGACAGCCACCTGATCCCTACGCCTCAAGCCCCCAGTATTGCCTTTCCACTCGCCAACCCCCCTGTGGCTCCGCACCCTAGAGAAAAGATTATAAC GATAGAGGAGACTCATGAAGAATTAAAAAAACAGTACATATTTCAGTTATCATCTCTGAATCCTCAAGAACGTATTGACTATTGTCATCTGATTGAGAAA CTAGGTGGATTGGTGATAGAAAAGCAGTGCTTTGATCCCACCTGTACACACATTGTTGTGGGACATCCACTTCGAAACGAGAAGTATTTAGCCTCAGTGG CAGCTGGGAAGTGGGTGCTTCATCGCTCCTACCTTGAAGCCTGCAGGACTGCTGGACACTTCGTGCAGGAAGAAGACTATGAATGGGGAAGTAGTTCCAT ACTTGATGTTCTGACTGGAATCAATGTACAGCAACGAAGACTAGCACTTGCAGCAATGAGATGGAGAAAAAAAATCCAGCAAAGACAAGAATCTGGCATT GTTGAGGGAGCATTTAGTGGGTGGAAGGTTATTTTACATGTGGATCAGTCTCGAGAAGCAGGCTTCAAACGCCTTCTTCAGTCAGGAGGAGCAAAGGTGC TACCTGGTCATTCTGTACCTTTATTTAAAGAGGCCACACATCTTTTTTCTGACTTGAATAAACTGAAACCAGATGACTCAGGAGTTAATATAGCAGAAGC TGCTGCCCAGAACGTGTACTGCTTGAGAACAGAATACATTGCTGATTATCTCATGCAGGAATCACCTCCTCATGTAGAAAATTACTGTCTACCAGAAGCT ATTTCATTTATTCAGAATAATAAGGAACTTGGGACTGGATTATCACAAAAGAGGAAAGCTCCTACAGAAAAAAATAAAATCAAACGACCTAGAGTACACT AATCGCATCTACCCTTTAGTTACCAAACATTAAATGTTTTTAAAAATTGAAAGCCTGAATGTGACTGTGATAGATTTGGGTAGTAATTTAAAGATGAGTA CCTGAAGAATTCTGCTTCAGAGTATAATGATGACCCTTCTTGAGTTTTGAACACCTGAAATTGTAATCACTGAAATATTAACTGTTTCTTAATAAAAAGT TACCTGAAATAACAACAAAATACAACTCCTCAGCTAGCTTGCTGTTAAACCACATTGAAGTCTGTTAAAAGATATTTATTTTTCTTGTAAATATCTGAAG CTGTAGCTTAGTGGAAATTTTAGCAAGGTAATGGATTTTGCTTTAAAATGTCTGCCTTACAAATTCATAACAACAAGATTTGTCAGTCAGCATTTATTCA TGTTTTCCCTGATTTTTATCTTCTCACCATTTTACCTCTTTTAACAGGAGCCTGAGCACAAGGTTTAATGAGGAAGCTGGGGCTATAAATATGTGTGTAT ATATGTATATGTATGTTTGTACAAATCTCCATGATGTTTGCCAAGTTTGAATGCGCAAAACTTGGAAAATGTGACAATAAAGAATAAAAGTAGTAACTCA AATTAGTATTAAGATGTGTTTACATAGATAAATTTTTTAAAAGAGCACCCTGGCATCTGTTCTTCTGTTGAAGCAACAAAACATTTATGTAACGTAAAAA ATGAATTGCAGGGGCCTGGGTGCGGTGGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCGTCTGAGGTCGGGAGTTTGAGACCA GCCTGACCAACATGGAGAAACCTCATCTGTACTAAAAATACAAAAAATTAGCCCAGTGTGGTGGCACATGCCTGTAATCCCAGCTACTCAGGAGGCTGAG GCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCGGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAA AAAAAAAAAAAAAAGAATTGCAGGCCAGGCACGGTGGCTCATGCTTGTAATCCCACCACTTTGGGAGGCCAAGGTGGGTGGACTGCTTGAACCCAGAAGT TCAAGACCAGCCTGGACAACATGGCGAAACCCCATCTCTGCAAAAAATAGCAAAAAATTAGCCGGGCATGCTGTTTGATGCTTGTAGTCCCAGCTACTTG GGAGGCTGAGGCATGAGAATTACTTGAACTCAGGAGGCAGAGGTTGCAGTGAGCTGAAATCATGCCACTGCAACTCCAGCCTGGGTGACAGAATGAGACC CTGTCTCAAAAAAAATAAATGAATTGCTTAACATTTCTGATATTTGTTATTTAGAATATTGCCCTATTAGATTAAAACATACTGTTATTGG

TOPBP1.u.f.8 (forward primer)
TOPBP1.u.r.8 (reverse primer)
Alternative acceptor

Frame 0

WGRGGAESGEGAVRRAGARPQPPPCGQRVPRLA ARRPRGSNEFRNVQK*QRTVFCEVFKVFRQFQMF F*SSRVHKRIPIRRISSDYYRRRGIEDKGE**I TLYL*PF*WRCL*SPQKAWLQNCWSSSSHILYA PPAMCPKSRTSSL*YGYV*CNHILYKSGKRKKGR SS*ICTNDGRTSIQRP*CISNSPYCRRSW*QKI FSCCKPEETYFASLLDKNTLGEVTREKNN*IY* YKHGRFQVSYFSWLHNLCDWLMWLRQERSSATHS *AWRSIHGTIENE*MYTPHCARTKRSEV*VCQE MECTLCDHTVVF*QY*ERFLSG*IHIQDRT*TR SKDYAQFFNSYQPDQHN**SYSFRCQQYFQHKCK LRK*INM*FT*QQTGAYT*KSRKSGCQCISST* RFIRWLSDISLRF*WQKAR*TEKTY*QWRWSSF *PAK*RCNSCYCGRL***IEAVLE*ISPQASCSG SKVVARVFQ*RLYAF*RTIYPC*LPASGNSSFT *A*K*SSSFKKEEQQLL*ERLCS**KA*AS**R SALSI*KW*LHSS*G*DV*SQAL**FYSC*ALE* FYSHFFARRKPVFCQSLCP*CFYNY*RRLI*PK EFPCFGF***K*I*HRKHHKRKCWENHVPSEQN CCGLCCGSSAGV*SGSHCGRSCYKYMAGYLHRLS DFV*SKVESSLHTSSSNDRNDSFRGLCYFI*PV CWSRKRVFNIPSKPPWSKCSRILCSQIQCKERH VCQYSSYTERTWWL*I*SCKEVEFTCRYYSLAVG DC*NGKESRRKPFSD*KFN*RRTKFGNRNNKWN QSKFRYCRASWHTPANSQKNRRYTFRYEPLSE* SFPCCGLTTCQTGRSLPSSRTTTSEGALVTPGYT IKIPVQGQTLQAFL*CEGCTCSLGNSRTSQPTE KETEYATLRSYCQKLATCFGK*LSKCCRSFCQP STERGPVREGRSPKATSQSSGMC**KTQ*EAE*T KWDRSLSRSRLQVEF**NSDSFHLSRAAK*H*S GV*ICKRKRSTHCFRALAFRLCPRV*TSS*ISL STYL*SQNELGYQRSARWPAL**STTLSCVFNKG **ARSFDFRRK*CRQYGHQ**RVSTIKWKWKE* L*RSSDTDLRDERELSEAVTGDNVCNINSETPR AEDFPFKKWL*QRIFNP*QHSLCSQWTK*SPRGT EAVSSDST*CQHRAFPK*TDHLG*PYSKGGESK ACQQFAVA*LSHTIL*ASG*HSKLGGFSFSKAF T*FRNC*TGCL*SWKHTCD*SSQTPNL*RTGNSH KRQPPDPYASSPQYCLSTRQPPCGSAP*RKDYN DRGDS*RIKKTVHISVIISESSRTY*LLSSD*E TRWIGDRKAVL*SHLYTHCCGTSTSKREVFSLSG SWEVGASSLLP*SLQDCWTLRAGRRL*MGK*FH T*CSDWNQCTATKTSTCSNEMEKKNPAKTRIWH C*GSI*WVEGYFTCGSVSRSRLQTPSSVRRSKGA TWSFCTFI*RGHTSFF*LE*TETR*LRS*YSRS CCPERVLLENRIHC*LSHAGITSSCRKLLSTRS YFIYSE**GTWDWIITKEESSYRKK*NQTT*STL IASTL*LPNIKCF*KLKA*M*L**IWVVI*R*V PEEFCFRV***PFLSFEHLKL*SLKY*LFLNKK LPEITTKYNSSASLLLNHIEVC*KIFIFLVNI*S CSLVEILAR*WILL*NVCLTNS*QQDLSVSIYS CFP*FLSSHHFTSFNRSLSTRFNEEAGAINMCV YMYMYVCTNLHDVCQV*MRKTWKM*Q*RIKVVTQ ISIKMCLHR*IF*KSTLASVLLLKQQNIYVT*K MNCRGLGAVARACNPSTLGG*GRRIV*GREFET SLTNMEKPHLY*KYKKLAQCGGTCL*SQLLRRLR QENRLNPGGGGCGELRSRHCTPAWATRAKLHLK KKKKKNCRPGTVAHACNPTTLGGQGGWTA*TQK FKTSLDNMAKPHLCKK*QKISRACCLMLVVPATW EAEA*ELLELRRQRLQ*AEIMPLQLQPG*QNET LSQKK*MNCLTFLIFVI*NIALLD*NILLL

Frame 1

GVGAAPSRGRGLCAGLAPDPSHRPAASASPDSP PGDPEAPTSSEMSRNDKEPFFVKFLKSSDNSKC FFKALESIKEFQSEEYLQIITEEEALKIKENDRS LYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMH HQRCVPRAEHPVYNMVMSDVTISCTSLEKEKRE EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKY LVAANLKKPILLPSWIKTLWEKSQEKKITRYTD INMEDFKCPIFLGCIICVTGLCGLDRKEVQQLT VKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKR WNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPE AKTMPNSSTPTSQINTIDSRTLSDVSNISNINA SCVSESICNSLNSKLEPTLENLENLDVSAFQAPE DLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRF NQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVV GAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSH KPESKAALLKKKNSSFSKKDFAPSEKHEQADED LLSQYENGSSTVVEAKTSEARPFNDSTHAEPLN DSTHISLQEENQSSVSHCVPDVSTITEEGLFSQK SFLVLGFSNENESNIANIIKENAGKIMSLLSRT VADYAVVPLLGCEVEATVGEVVTNTWLVTCIDY QTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQC AGAEKESLTFLANLLGASVQEYFVRKSNAKKGM FASTHLILKERGGSKYEAAKKWNLPAVTIAWLL ETARTGKRADESHFLIENSTKEERSLETEITNGI NLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSK AFRAVVSQHARQVAASPAVGQPLQKEPSLHLDT PSKFLSKDKLFKPSFDVKDALAALETPGRPSQQK RKPSTPLSEVIVKNLQLALANSSRNAVALSASP QLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSE LNGIAASLGADYRWSFDETVTHFIYQGRPNDTNR EYKSVKERGVHIVSEHWLLDCAQECKHLPESLY PHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTK DDEPDPLILEENDVDNMATNNKESAPSNGSGKND SKGVLTQTLEMRENFQKQLQEIMSATSIVKPQG QRTSLSRSGCNSASSTPDSTRSARSGRSRVLEA LRQSRQTVPDVNTEPSQNEQIIWDDPTAREERAR LASNLQWPSCPTQYSELQVDIQNLEDSPFQKPL HDSEIAKQAVCDPGNIRVTEAPKHPISEELETP IKDSHLIPTPQAPSIAFPLANPPVAPHPREKIIT IEETHEELKKQYIFQLSSLNPQERIDYCHLIEK LGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASV AAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSI LDVLTGINVQQRRLALAAMRWRKKIQQRQESGI VEGAFSGWKVILHVDQSREAGFKRLLQSGGAKV LPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEA AAQNVYCLRTEYIADYLMQESPPHVENYCLPEA ISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH *SHLPFSYQTLNVFKN*KPECDCDRFG**FKDEY LKNSASEYNDDPS*VLNT*NCNH*NINCFLIKS YLK*QQNTTPQLACC*TTLKSVKRYLFFL*ISE AVA*WKF*QGNGFCFKMSALQIHNNKICQSAFIH VFPDFYLLTILPLLTGA*AQGLMRKLGL*ICVY ICICMFVQISMMFAKFECAKLGKCDNKE*K**L KLVLRCVYIDKFFKRAPWHLFFC*SNKTFM*RKK *IAGAWVRWLVPVIPALWEAEAGGSSEVGSLRP A*PTWRNLICTKNTKN*PSVVAHACNPSYSGG* GRRIA*TREAEVAVS*DRAIALQPGQQERNSISK KKKKRIAGQARWLMLVIPPLWEAKVGGLLEPRS SRPAWTTWRNPISAKNSKKLAGHAV*CL*SQLL GRLRHENYLNSGGRGCSELKSCHCNSSLGDRMRP CLKKNK*IA*HF*YLLFRILPY*IKTYCYW

Frame 2

G*GRRRVGGGGCAPGWRPTPATALRPARPPTRR PETPRLQRVQKCPEMTKNRFL*SF*SLQTIPNV FLKLSSP*KNSNQKNIFRLLQKKRH*R*RRMID HFISVTLLVALSLITSKSLAAELLVLK*SYFVCT TSDVSQEPNIQFIIWLCLM*PYLVQVWKKKKGK KFINMYK*WADEYTETLMYQ*LTLLQEKLVAKN I*LLQT*RNLFCFPLG*KHFGRSHKRKK*LDILI *TWKISSVLFFLVA*SV*LAYVA*TGKKFSNSQ LSMEVNTWDN*K*MNVHTSLCKNQKVRSMSVPR DGMYTV*PHSGFLTVLRKVFVRMNPYTRQNLDQK QRLCPILQLLPARSTQLIVVLFQMSAIFPT*MQ VA*VNQYVIHLTANWSLHLKI*KIWMSVHFKHL KIY*MVVGYIFAVLVAES*IN*EDLLTVEVEFVL TS*MKM*LMLLWEIMMMN*SSFGINQPTGLM*W EQSGC*SVSVKVICFLKNHISMLITSQWKFQFH ISLKVKQLF*KRRTAASLRKTLLLVKSMSKLMKI CSLNMKMVAPQ*LRLRRLKPGPLMILLMLSP*M ILLTFLCKKKTSLLSVIVSLMFLQLLKKAYLAK RVSLFWVLVMKMNLTSQTS*KKMLGKSCPF*AEL LRIMLWFLCWGVKWKPLWEKLLQIHGWLLA*TI RLCLIQSRILSSHQFQ**QE*LL*RIVLFHLAS VLEQKKSL*HS*QTSLEQVFKNTLFANPMQRKAC LPVLILY*KNVVALNMKLQRSGIYLPLL*LGCW RLLEREREQTKAIF*LKIQLKKNEVWKQK*QME SI*IQILQSILAHACKLTEKPSLHL*I*TAFRVK LSVLWSHNMPDRSQPPQQ*DNHFRRSPRYTWIH HQNSCPRTNSSSLPLM*RMHLQPWKLQDVPANR KGNRVRHSQKLLSKTCNLLWQIALEMLSLFLPAL N*KRPSQRRKKPQSHFTK*WYVLVKNSVRSRVN *MGSQPL*EQITGGVLMKQ*LISSIKGGQMTLI GSINL*KKEEYTLFPSTGF*IVPKSVNIFLNLFI HILIIPK*AWISAQCKMAGSVIVDYSQLCLQQR MMSQIL*F*KKMM*TIWPPIIKSQHHQMEVERM TLKEF*HRP*R*ERTFRSSYRR*CLQHQ**NPKG RGLPFQEVVVTAHLQPLTALALLAVDEVES*RH *GSLVRQYLMSTQSLPKMNRSFGMTLQQGRREQ GLPAICSGLVVPHNTLSFRLTFKTWRILLFKSLY MIQKLLNRLSVILETYV*LKLPNTQSLKNWKLP *KTAT*SLRLKPPVLPFHSPTPLWLRTLEKRL* R*RRLMKN*KNSTYFSYHL*ILKNVLTIVI*LRN *VDW**KSSALIPPVHTLLWDIHFETRSI*PQW QLGSGCFIAPTLKPAGLLDTSCRKKTMNGEVVP YLMF*LESMYSNED*HLQQ*DGEKKSSKDKNLAL LREHLVGGRLFYMWISLEKQASNAFFSQEEQRC YLVILYLYLKRPHIFFLT*IN*NQMTQELI*QK LLPRTCTA*EQNTLLIISCRNHLLM*KITVYQKL FHLFRIIRNLGLDYHKRGKLLQKKIKSNDLEYT NRIYPLVTKH*MFLKIESLNVTVIDLGSNLKMS T*RILLQSIMMTLLEF*TPEIVITEILTVS**KV T*NNNKIQLLS*LAVKPH*SLLKDIYFSCKYLK L*LSGNFSKVMDFALKCLPYKFITTRFVSQHLF MFSLIFIFSPFYLF*QEPEHKV**GSWGYKYVCI YVYVCLYKSP*CLPSLNAQNLENVTIKNKSSNS N*Y*DVFT*INFLKEHPGICSSVEATKHLCNVK NELQGPGCGGSCL*SQHFGRLRQADRLRSGV*DQ PDQHGETSSVLKIQKISPVWWHMPVIPATQEAE AGESLEPGRRRLR*AEIAPLHSSLGNKSETPSQ KKKKKELQARHGGSCL*SHHFGRPRWVDCLNPEV QDQPGQHGETPSLQKIAKN*PGMLFDACSPSYL GG*GMRIT*TQEAEVAVS*NHATATPAWVTE*D PVSKKINELLNISDICYLEYCPIRLKHTVI