Sequences - Rnomics 📊 Palace

        ☰
    
        Rnomics 📊 Palace
    
                       Back to Rnomics Platform
            
                       Open Session

1 warning:

Access restricted to public data.
Please sign in at Rnomics Platform to access your data.

Navigation

Home

Sequences

Sequence PTPN13.cAug05

GAGTAGCTCCAGCGGCCACGCTGAGGCGAGGGTGACACACCATGCTCACGGCCCCTGGAGACCGTCGTGCTGGCGAGCCGTGCTCCGTAGCTCCCCGGTC CGCCTCGGCAGCGGTCAGAGTCGCCTACAGGAGTTGAGCCGCCCGCGCCAGAAGGTTTTGGCGAAGCTCTTGGAGAGGCGTCGAGCACAGTAGGGCGGCG GGGGTGCGTTGAGCGCTCGGGGGTCAGGCAGTCGGCCGGGATCGCCGCTGGGGAGCGTTTCCGAGGCGAGGAGGAGGAGGAGGAGATGCTGCTCCTCTTC TCCCCCTCCCCAGGCTCCTTCTACAGCTCCTTCAGCCCACGCCCGCAGCCGCTTGTGGGAGAAGTGGTGGTGGCTCTCGGCGCCCGCGGCGGCTGCCGGC GGCCCGCCCCGACGCCGCGTCCCTGCAGCCCTCGCCCGGCGCTCCAGTAGCAGGACCCGGTCTCGGGACCAGCCGGTAATATGCACGTGTCACTAGCTGA GGCCCTGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTGTATTAAATCAAAGTGCTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGC CTAGCTGATCCTGCTGCCCTTGGCTTCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTTACAGATGAAAATATTTCCAATC AGGATCTTCGAGCATTCACTGCACCAGAGGTTCTTCAAAATCAGTCACTAACTTCTCTCTCAGATGTTGAAAAGATCCACATTTATTCTCTTGGAATGAC ACTGTATTGGGGGGCTGATTATGAAGTGCCTCAGAGCCAACCTATTAAGCTTGGAGATCATCTCAACAGCATACTGCTTGGAATGTGTGAGGATGTTATT TACGCTCGAGTTTCTGTTCGGACTGTGCTGGATGCTTGCAGTGCCCACATTAGGAATAGCAATTGTGCACCCTCATTTTCCTACGTGAAACACTTGGTAA AACTGGTTCTGGGAAATCTTTCTGGGACAGATCAGCTTTCCTGTAACAGTGAACAAAAGCCTGATCGAAGCCAGGCTATTCGAGATCGATTGCGAGGAAA AGGATTACCAACAGGAAGAAGCTCTACTTCTGATGTACTAGACATACAAAAGCCTCCACTCTCTCATCAGACCTTTCTTAACAAAGGGCTTAGTAAATCT ATGGGATTTCTGTCCATCAAAGATACACAAGATGAGAATTATTTCAAGGACATTTTATCAGATAATTCTGGACGTGAAGATTCTGAAAATACATTCTCCC CTTACCAGTTCAAAACTAGTGGCCCAGAAAAAAAACCCATCCCTGGCATTGATGTGCTTTCTAAGAAGAAGATCTGGGCTTCATCCATGGACTTGCTTTG TACAGCTGACAGAGACTTCTCTTCAGGAGAGACTGCCACATATCGTCGTTGTCACCCTGAGGCAGTAACAGTGCGGACTTCAACTACTCCTAGAAAAAAG GAGGCAAGATACTCAGATGGAAGTATAGCCTTGGATATCTTTGGCCCTCAGAAAATGGATCCAATATATCACACTCGAGAATTGCCCACCTCCTCAGCAA TATCAAGTGCTTTGGACCGAATCCGAGAGAGACAAAAGAAACTTCAGGTTCTGAGGGAAGCCATGAATGTAGAAGAACCAGTTCGAAGATACAAAACTTA TCATGGTGATGTCTTTAGTACCTCCAGTGAAAGTCCATCTATTATTTCCTCTGAATCAGATTTCAGACAAGTGAGAAGAAGTGAAGCCTCAAAGAGGTTT GAATCCAGCAGTGGTCTCCCAGGGGTAGATGAAACCTTAAGTCAAGGCCAGTCACAGAGACCGAGCAGACAATATGAAACACCCTTTGAAGGCAACTTAA TTAATCAAGAGATCATGCTAAAACGGCAAGAGGAAGAACTGATGCAGCTACAAGCCAAAATGGCCCTTAGACAGTCTCGGTTGAGCCTATATCCAGGAGA CACAATCAAAGCGTCCATGCTTGACATCACCAGGGATCCGTTAAGAGAAATTGCCCTAGAAACAGCCATGACTCAAAGAAAACTGAGGAATTTCTTTGGC CCTGAGTTTGTGAAAATGACAATTGAACCATTTATATCTTTGGATTTGCCACGGTCTATTCTTACTAAGAAAGGGAAGAATGAGGATAACCGAAGGAAAG TAAACATAATGCTTCTGAACGGGCAAAGACTGGAACTGACCTGTGATACCAAAACTATATGTAAAGATGTGTTTGATATGGTTGTGGCACATATTGGCTT AGTAGAGCATCATTTGTTTGCTTTAGCTACCCTCAAAGATAATGAATATTTCTTTGTTGATCCTGACTTAAAATTAACCAAAGTGGCCCCAGAGGGATGG AAAGAAGAACCAAAGAAAAAGACCAAAGCCACTGTTAATTTTACTTTGTTTTTCAGAATTAAATTTTTTATGGATGATGTTAGTCTAATACAACATACTC TGACGTGTCATCAGTATTACCTTCAGCTTCGAAAAGATATTTTGGAGGAAAGGATGCACTGTGATGATGAGACTTCCTTATTGCTGGCATCCTTGGCTCT CCAGGCTGAGTATGGAGATTATCAACCAGAGGTTCATGGTGTGTCTTACTTTAGAATGGAGCACTATTTGCCCGCCAGAGTGATGGAGAAACTTGATTTA TCCTATATCAAAGAAGAGTTACCCAAATTGCATAATACCTATGTGGGAGCTTCTGAAAAAGAGACAGAGTTAGAATTTTTAAAGGTCTGCCAAAGACTGA CAGAATATGGAGTTCATTTTCACCGAGTGCACCCTGAGAAGAAGTCACAAACAGGAATATTGCTTGGAGTCTGTTCTAAAGGTGTCCTTGTGTTTGAAGT TCACAATGGAGTGCGCACATTGGTCCTTCGCTTTCCATGGAGGGAAACCAAGAAAATATCTTTTTCTAAAAAGAAAATCACATTGCAAAATACATCAGAT GGAATAAAACATGGCTTCCAGACAGACAACAGTAAGATATGCCAGTACCTGCTGCACCTCTGCTCTTACCAGCATAAGTTCCAGCTACAGATGAGAGCAA GACAGAGCAACCAAGATGCCCAAGATATTGAGAGAGCTTCGTTTAGGAGCCTGAATCTCCAAGCAGAGTCTGTTAGAGGATTTAATATGGGACGAGCAAT CAGCACTGGCAGTCTGGCCAGCAGCACCCTCAACAAACTTGCTGTTCGACCTTTATCAGTTCAAGCTGAGATTCTGAAGAGGCTATCCTGCTCAGAGCTG TCGCTTTACCAGCCATTGCAAAACAGTTCAAAAGAGAAGAATGACAAAGCTTCATGGGAGGAAAAGCCTAGAGAGATGAGTAAATCATACCATGATCTCA GTCAGGCCTCTCTCTATCCACATCGGAAAAATGTCATTGTTAACATGGAACCCCCACCACAAACCGTTGCAGAGTTGGTGGGAAAACCTTCTCACCAGAT GTCAAGATCTGATGCAGAATCTTTGGCAGGAGTGACAAAACTTAATAATTCAAAGTCTGTTGCGAGTTTAAATAGAAGTCCTGAAAGGAGGAAACATGAA TCAGACTCCTCATCCATTGAAGACCCTGGGCAAGCATATGTTCTAGATGTGCTACACAAAAGATGGAGCATAGTATCTTCACCAGAAAGGGAGATCACCT TAGTGAACCTGAAAAAAGATGCAAAGTATGGCTTGGGATTTCAAATTATTGGTGGGGAGAAGATGGGAAGACTGGACCTAGGCATATTTATCAGTTCAGT TGCCCCTGGAGGACCAGCTGACTTGGATGGATGCTTGAAGCCAGGAGACCGTTTGATATCTGTGAATAGTGTGAGTCTGGAGGGAGTCAGCCACCATGCT GCAATTGAAATTTTGCAAAATGCACCTGAAGATGTGACACTTGTTATCTCTCAGCCAAAAGAAAAGATATCCAAAGTGCCTTCTACTCCTGTGCATCTCA CCAATGAGATGAAAAACTACATGAAGAAATCTTCCTACATGCAAGACAGTGCTATAGATTCTTCTTCCAAGGATCACCACTGGTCACGTGGTACCCTGAG GCACATCTCGGAGAACTCCTTTGGGCCATCTGGGGGCCTGCGGGAAGGAAGCCTGAGTTCTCAAGATTCCAGGACTGAGAGTGCCAGCTTGTCTCAAAGC CAGGTCAATGGTTTCTTTGCCAGCCATTTAGGTGACCAAACCTGGCAGGAATCACAGCATGGCAGCCCTTCCCCATCTGTAATATCCAAAGCCACCGAGA AAGAGACTTTCACTGATAGTAACCAAAGCAAAACTAAAAAGCCAGGCATTTCTGATGTAACTGATTACTCAGACCGTGGAGATTCAGACATGGATGAAGC CACTTACTCCAGCAGTCAGGATCATCAAACACCAAAACAGGAATCTTCCTCTTCAGTGAATACATCCAACAAGATGAATTTTAAAACTTTTTCTTCATCA CCTCCTAAGCCTGGAGATATCTTTGAGGTTGAACTGGCTAAAAATGATAACAGCTTGGGGATAAGTGTCACGGGAGGTGTGAATACGAGTGTCAGACATG GTGGCATTTATGTGAAAGCTGTTATTCCCCAGGGAGCAGCAGAGTCTGATGGTAGAATTCACAAAGGTGATCGCGTCCTAGCTGTCAATGGAGTTAGTCT AGAAGGAGCCACCCATAAGCAAGCTGTGGAAACACTGAGAAATACAGGACAGGTGGTTCATCTGTTATTAGAAAAGGGACAATCTCCAACATCTAAAGAA CATGTCCCGGTAACCCCACAGTGTACCCTTTCAGATCAGAATGCCCAAGGTCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAGGTCAAAGACTACAGCT TTGTCACTGAAGAAAATACATTTGAGGTAAAATTATTTAAAAATAGCTCAGGTCTAGGATTCAGTTTTTCTCGAGAAGATAATCTTATACCGGAGCAAAT TAATGCCAGCATAGTAAGGGTTAAAAAGCTCTTTCCTGGACAGCCAGCAGCAGAAAGTGGAAAAATTGATGTAGGAGATGTTATCTTGAAAGTGAATGGA GCCTCTTTGAAAGGACTATCTCAGCAGGAAGTCATATCTGCTCTCAGGGGAACTGCTCCAGAAGTATTCTTGCTTCTCTGCAGACCTCCACCTGGTGTGC TACCGGAAATTGATACTGCGCTTTTGACCCCACTTCAGTCTCCAGCACAAGTACTTCCAAACAGCAGTAAAGACTCTTCTCAGCCATCATGTGTGGAGCA AAGCACCAGCTCAGATGAAAATGAAATGTCAGACAAAAGCAAAAAACAGTGCAAGTCCCCATCCAGAAGAGACAGTTACAGTGACAGCAGTGGGAGTGGA GAAGATGACTTAGTGACAGCTCCAGCAAACATATCAAATTCGACCTGGAGTTCAGCTTTGCATCAGACTCTAAGCAACATGGTATCACAGGCACAGAGTC ATCATGAAGCACCCAAGAGTCAAGAAGATACCATTTGTACCATGTTTTACTATCCTCAGAAAATTCCCAATAAACCAGAGTTTGAGGACAGTAATCCTTC CCCTCTACCACCGGATATGGCTCCTGGGCAGAGTTATCAACCCCAATCAGAATCTGCTTCCTCTAGTTCGATGGATAAGTATCATATACATCACATTTCT GAACCAACTAGACAAGAAAACTGGACACCTTTGAAAAATGACTTGGAAAATCACCTTGAAGACTTTGAACTGGAAGTAGAACTCCTCATTACCCTAATTA AATCAGAAAAAGGAAGCCTGGGTTTTACAGTAACCAAAGGCAATCAGAGAATTGGTTGTTATGTTCATGATGTCATACAGGATCCAGCCAAAAGTGATGG AAGGCTAAAACCTGGGGACCGGCTCATAAAGGTTAATGATACAGATGTTACTAATATGACTCATACAGATGCAGTTAATCTGCTCCGGGCTGCATCCAAA ACAGTCAGATTAGTTATTGGACGAGTTCTAGAATTACCCAGAATACCAATGTTGCCTCATTTGCTACCGGACATAACACTAACGTGCAACAAAGAGGAGT TGGGTTTTTCCTTATGTGGAGGTCATGACAGCCTTTATCAAGTGGTATATATTAGTGATATTAATCCAAGGTCCGTCGCAGCCATTGAGGGTAATCTCCA GCTATTAGATGTCATCCATTATGTGAACGGAGTCAGCACACAAGGAATGACCTTGGAGGAAGTTAACAGAGCATTAGACATGTCACTTCCTTCATTGGTA TTGAAAGCAACAAGAAATGATCTTCCAGTGGTCCCCAGCTCAAAGAGGTCTGCTGTTTCAGCTCCAAAGTCAACCAAAGGCAATGGTTCCTACAGTGTGG GGTCTTGCAGCCAGCCTGCCCTCACTCCTAATGATTCATTCTCCACGGTTGCTGGGGAAGAAATAAATGAAATATCGTACCCCAAAGGAAAATGTTCTAC TTATCAGATAAAGGGATCACCAAACTTGACTCTGCCCAAAGAATCTTATATACAAGAAGATGACATTTATGATGATTCCCAAGAAGCTGAAGTTATCCAG TCTCTGCTGGATGTTGTGGATGAGGAAGCCCAGAATCTTTTAAACGAAAATAATGCAGCAGGATACTCCTGTGGTCCAGGTACATTAAAGATGAATGGGA AGTTATCAGAAGAGAGAACAGAAGATACAGACTGCGATGGTTCACCTTTACCTGAGTATTTTACTGAGGCCACCAAAATGAATGGCTGTGAAGAATATTG TGAAGAAAAAGTAAAAAGTGAAAGCTTAATTCAGAAGCCACAAGAAAAGAAGACTGATGATGATGAAATAACATGGGGAAATGATGAGTTGCCAATAGAG AGAACAAACCATGAAGATTCTGATAAAGATCATTCCTTTCTGACAAACGATGAGCTCGCTGTACTCCCTGTCGTCAAAGTGCTTCCCTCTGGTAAATACA CGGGTGCCAACTTAAAATCAGTCATTCGAGTCCTGCGGGGTTTGCTAGATCAAGGAATTCCTTCTAAGGAGCTGGAGAATCTTCAAGAATTAAAACCTTT GGATCAGTGTCTAATTGGGCAAACTAAGGAAAACAGAAGGAAGAACAGATATAAAAATATACTTCCCTATGATGCTACAAGAGTGCCTCTTGGAGATGAA GGTGGCTATATCAATGCCAGCTTCATTAAGATACCAGTTGGGAAAGAAGAGTTCGTTTACATTGCCTGCCAAGGACCACTGCCTACAACTGTTGGAGACT TCTGGCAGATGATTTGGGAGCAAAAATCCACAGTGATAGCCATGATGACTCAAGAAGTAGAAGGAGAAAAAATCAAATGCCAGCGCTATTGGCCCAACAT CCTAGGCAAAACAACAATGGTCAGCAACAGACTTCGACTGGCTCTTGTGAGAATGCAGCAGCTGAAGGGCTTTGTGGTGAGGGCAATGACCCTTGAAGAT ATTCAGACCAGAGAGGTGCGCCATATTTCTCATCTGAATTTCACTGCCTGGCCAGACCATGATACACCTTCTCAACCAGATGATCTGCTTACTTTTATCT CCTACATGAGACACATCCACAGATCAGGCCCAATCATTACGCACTGCAGTGCTGGCATTGGACGTTCAGGGACCCTGATTTGCATAGATGTGGTTCTGGG ATTAATCAGTCAGGATCTTGATTTTGACATCTCTGATTTGGTGCGCTGCATGAGACTACAAAGACACGGAATGGTTCAGACAGAGGATCAATATATTTTC TGCTATCAAGTCATCCTTTATGTCCTGACACGTCTTCAAGCAGAAGAAGAGCAAAAACAGCAGCCTCAGCTTCTGAAGTGACATGAAAAGAGCCTCTGGA TGCATTTCCATTTCTCTCCTTAACCTCCAGCAGACTCCTGCTCTCTATCCAAAATAAAGATCACAGAGCAGCAAGTTCATACAACATGCATGTTCTCCTC TATCTTAGAGGGGTATTCTTCTTGAAAATAAAAAATATTGAAATGCTGTATTTTTACAGCTACTTTAACCTATGATAATTATTTACAAAATTTTAACACT AACCAAACAATGCAGATCTTAGGGATGATTAAAGGCAGCATTTGATGATAGCAGACATTGTTACAAGGACATGGTGAGTCTATTTTTAATGCACCAATCT TGTTTATAGCAAAAATGTTTTCCAATATTTTAATAAAGTAGTTATTTTATAGGGGATACTTGAAACCAGTATTTAAGCTTTAAATGACAGTAATATTGGC ATAGAAAAAAGTAGCAAATGTTTACTGTATCAATTTCTAATGTTTACTATATAGAATTTCCTGTAATATATTTATATACTTTTTCATGAAAATGGAGTTA TCAGTTATCTGTTTGTTACTGCATCATCTGTTTGTAATCATTATCTCACTTTGTAAATAAAAACACACCTTAAAACATGAACAAGCCAAAACTGTGTGCA GAC

PTPN13.F7 (forward primer)
PTPN13.R7 (reverse primer)
Single exon skipping

Frame 0

E*LQRPR*GEGDTPCSRPLETVVLASRAP*LPG PPRQRSESPTGVEPPAPEGFGEALGEASSTVGRR GCVERSGVRQSAGIAAGERFRGEEEEEEMLLLF SPSPGSFYSSFSPRPQPLVGEVVVALGARGGCR RPAPTPRPCSPRPALQ*QDPVSGPAGNMHVSLAE ALEVRGGPLQEEEIWAVLNQSAESLQELFRKVS LADPAALGFIISPWSLLLLPSGSVSFTDENISN QDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMT LYWGADYEVPQSQPIKLGDHLNSILLGMCEDVI YARVSVRTVLDACSAHIRNSNCAPSFSYVKHLV KLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGK GLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS MGFLSIKDTQDENYFKDILSDNSGREDSENTFS PYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLC TADRDFSSGETATYRRCHPEAVTVRTSTTPRKK EARYSDGSIALDIFGPQKMDPIYHTRELPTSSA ISSALDRIRERQKKLQVLREAMNVEEPVRRYKTY HGDVFSTSSESPSIISSESDFRQVRRSEASKRF ESSSGLPGVDETLSQGQSQRPSRQYETPFEGNL INQEIMLKRQEEELMQLQAKMALRQSRLSLYPGD TIKASMLDITRDPLREIALETAMTQRKLRNFFG PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRK VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGL VEHHLFALATLKDNEYFFVDPDLKLTKVAPEGW KEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHT LTCHQYYLQLRKDILEERMHCDDETSLLLASLAL QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL SYIKEELPKLHNTYVGASEKETELEFLKVCQRL TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEV HNGVRTLVLRFPWRETKKISFSKKKITLQNTSD GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRA RQSNQDAQDIERASFRSLNLQAESVRGFNMGRAI STGSLASSTLNKLAVRPLSVQAEILKRLSCSEL SLYQPLQNSSKEKNDKASWEEKPREMSKSYHDL SQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQM SRSDAESLAGVTKLNNSKSVASLNRSPERRKHE SDSSSIEDPGQAYVLDVLHKRWSIVSSPEREIT LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV APGGPADLDGCLKPGDRLISVNSVSLEGVSHHA AIEILQNAPEDVTLVISQPKEKISKVPSTPVHL TNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLR HISENSFGPSGGLREGSLSSQDSRTESASLSQS QVNGFFASHLGDQTWQESQHGSPSPSVISKATE KETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEA TYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSS PPKPGDIFEVELAKNDNSLGISVTGGVNTSVRH GGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL EGATHKQAVETLRNTGQVVHLLLEKGQSPTSKE HVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS FVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQI NASIVRVKKLFPGQPAAESGKIDVGDVILKVNG ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGV LPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQ STSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG EDDLVTAPANISNSTWSSALHQTLSNMVSQAQS HHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPS PLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS EPTRQENWTPLKNDLENHLEDFELEVELLITLI KSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG RLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK TVRLVIGRVLELPRIPMLPHLLPDITLTCNKEE LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQ LLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV LKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSV GSCSQPALTPNDSFSTVAGEEINEISYPKGKCST YQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQ SLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNG KLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYC EEKVKSESLIQKPQEKKTDDDEITWGNDELPIE RTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKY TGANLKSVIRVLRGLLDQGIPSKELENLQELKPL DQCLIGQTKENRRKNRYKNILPYDATRVPLGDE GGYINASFIKIPVGKEEFVYIACQGPLPTTVGD FWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNI LGKTTMVSNRLRLALVRMQQLKGFVVRAMTLED IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFI SYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLG LISQDLDFDISDLVRCMRLQRHGMVQTEDQYIF CYQVILYVLTRLQAEEEQKQQPQLLK*HEKSLW MHFHFSP*PPADSCSLSKIKITEQQVHTTCMFSS ILEGYSS*K*KILKCCIFTATLTYDNYLQNFNT NQTMQILGMIKGSI***QTLLQGHGESIFNAPI LFIAKMFSNILIK*LFYRGYLKPVFKL*MTVILA *KKVANVYCINF*CLLYRISCNIFIYFFMKMEL SVICLLLHHLFVIIISLCK*KHTLKHEQAKTVC R

Frame 1

SSSSGHAEARVTHHAHGPWRPSCWRAVLRSSPV RLGSGQSRLQELSRPRQKVLAKLLERRRAQ*GG GGALSARGSGSRPGSPLGSVSEARRRRRRCCSSS PPPQAPSTAPSAHARSRLWEKWWWLSAPAAAAG GPPRRRVPAALARRSSSRTRSRDQPVICTCH*L RPWRFGVDHFRRKKYGLY*IKVLKVSKNYSEK*A *LILLPLASSFLHGLCCCCHLVVCHLQMKIFPI RIFEHSLHQRFFKISH*LLSQMLKRSTFILLE* HCIGGLIMKCLRANLLSLEIISTAYCLECVRMLF TLEFLFGLCWMLAVPTLGIAIVHPHFPT*NTW* NWFWEIFLGQISFPVTVNKSLIEARLFEIDCEE KDYQQEEALLLMY*TYKSLHSLIRPFLTKGLVNL WDFCPSKIHKMRIISRTFYQIILDVKILKIHSP LTSSKLVAQKKNPSLALMCFLRRRSGLHPWTCF VQLTETSLQERLPHIVVVTLRQ*QCGLQLLLEKR RQDTQMEV*PWISLALRKWIQYITLENCPPPQQ YQVLWTESERDKRNFRF*GKP*M*KNQFEDTKL IMVMSLVPPVKVHLLFPLNQISDK*EEVKPQRGL NPAVVSQG*MKP*VKASHRDRADNMKHPLKAT* LIKRSC*NGKRKN*CSYKPKWPLDSLG*AYIQE TQSKRPCLTSPGIR*EKLP*KQP*LKEN*GISLA LSL*K*QLNHLYLWICHGLFLLRKGRMRITEGK *T*CF*TGKDWN*PVIPKLYVKMCLIWLWHILA **SIICLL*LPSKIMNISLLILT*N*PKWPQRDG KKNQRKRPKPLLILLCFSELNFLWMMLV*YNIL *RVISITFSFEKIFWRKGCTVMMRLPYCWHPWL SRLSMEIINQRFMVCLTLEWSTICPPE*WRNLIY PISKKSYPNCIIPMWELLKKRQS*NF*RSAKD* QNMEFIFTECTLRRSHKQEYCLESVLKVSLCLK FTMECAHWSFAFHGGKPRKYLFLKRKSHCKIHQM E*NMASRQTTVRYASTCCTSALTSISSSYR*EQ DRATKMPKILRELRLGA*ISKQSLLEDLIWDEQ SALAVWPAAPSTNLLFDLYQFKLRF*RGYPAQSC RFTSHCKTVQKRRMTKLHGRKSLER*VNHTMIS VRPLSIHIGKMSLLTWNPHHKPLQSWWENLLTR CQDLMQNLWQE*QNLIIQSLLRV*IEVLKGGNMN QTPHPLKTLGKHMF*MCYTKDGA*YLHQKGRSP **T*KKMQSMAWDFKLLVGRRWEDWT*AYLSVQ LPLEDQLTWMDA*SQETV*YL*IV*VWRESATML QLKFCKMHLKM*HLLSLSQKKRYPKCLLLLCIS PMR*KTT*RNLPTCKTVL*ILLPRITTGHVVP* GTSRRTPLGHLGACGKEA*VLKIPGLRVPACLKA RSMVSLPAI*VTKPGRNHSMAALPHL*YPKPPR KRLSLIVTKAKLKSQAFLM*LITQTVEIQTWMK PLTPAVRIIKHQNRNLPLQ*IHPTR*ILKLFLHH LLSLEISLRLNWLKMITAWG*VSREV*IRVSDM VAFM*KLLFPREQQSLMVEFTKVIAS*LSMELV *KEPPISKLWKH*EIQDRWFICY*KRDNLQHLKN MSR*PHSVPFQIRMPKVKAQKK*RKQLRSKTTA LSLKKIHLR*NYLKIAQV*DSVFLEKIILYRSK LMPA**GLKSSFLDSQQQKVEKLM*EMLS*K*ME PL*KDYLSRKSYLLSGELLQKYSCFSADLHLVC YRKLILRF*PHFSLQHKYFQTAVKTLLSHHVWS KAPAQMKMKCQTKAKNSASPHPEETVTVTAVGVE KMT**QLQQTYQIRPGVQLCIRL*ATWYHRHRV IMKHPRVKKIPFVPCFTILRKFPINQSLRTVIL PLYHRIWLLGRVINPNQNLLPLVRWISIIYITFL NQLDKKTGHL*KMTWKITLKTLNWK*NSSLP*L NQKKEAWVLQ*PKAIRELVVMFMMSYRIQPKVM EG*NLGTGS*RLMIQMLLI*LIQMQLICSGLHPK QSD*LLDEF*NYPEYQCCLICYRT*H*RATKRS WVFPYVEVMTAFIKWYILVILIQGPSQPLRVIS SY*MSSIM*TESAHKE*PWRKLTEH*TCHFLHWY *KQQEMIFQWSPAQRGLLFQLQSQPKAMVPTVW GLAASLPSLLMIHSPRLLGKK*MKYRTPKENVL LIR*RDHQT*LCPKNLIYKKMTFMMIPKKLKLSS LCWMLWMRKPRIF*TKIMQQDTPVVQVH*R*MG SYQKREQKIQTAMVHLYLSILLRPPK*MAVKNI VKKK*KVKA*FRSHKKRRLMMMK*HGEMMSCQ*R EQTMKILIKIIPF*QTMSSLYSLSSKCFPLVNT RVPT*NQSFESCGVC*IKEFLLRSWRIFKN*NL WISV*LGKLRKTEGRTDIKIYFPMMLQECLLEMK VAISMPASLRYQLGKKSSFTLPAKDHCLQLLET SGR*FGSKNPQ**P**LKK*KEKKSNASAIGPT S*AKQQWSATDFDWLL*ECSS*RALW*GQ*PLKI FRPERCAIFLI*ISLPGQTMIHLLNQMICLLLS PT*DTSTDQAQSLRTAVLALDVQGP*FA*MWFW D*SVRILILTSLIWCAA*DYKDTEWFRQRINIFS AIKSSFMS*HVFKQKKSKNSSLSF*SDMKRASG CISISLLNLQQTPALYPK*RSQSSKFIQHACSP LS*RGILLENKKY*NAVFLQLL*PMIIIYKILTL TKQCRS*G*LKAAFDDSRHCYKDMVSLFLMHQS CL*QKCFPIF**SSYFIGDT*NQYLSFK*Q*YW HRKK*QMFTVSISNVYYIEFPVIYLYTFS*KWSY QLSVCYCIICL*SLSHFVNKNTP*NMNKPKLCA D

Frame 2

VAPAATLRRG*HTMLTAPGDRRAGEPCSVAPRS ASAAVRVAYRS*AARARRFWRSSWRGVEHSRAA GVR*ALGGQAVGRDRRWGAFPRRGGGGGDAAPL LPLPRLLLQLLQPTPAAACGRSGGGSRRPRRLPA ARPDAASLQPSPGAPVAGPGLGTSR*YARVTS* GPGGSGWTTSGGRNMGCIKSKC*KSPRIIQKSK PS*SCCPWLHHFSMVSAVAAIW*CVIYR*KYFQS GSSSIHCTRGSSKSVTNFSLRC*KDPHLFSWND TVLGG*L*SASEPTY*AWRSSQQHTAWNV*GCY LRSSFCSDCAGCLQCPH*E*QLCTLIFLRETLGK TGSGKSFWDRSAFL*Q*TKA*SKPGYSRSIARK RITNRKKLYF*CTRHTKASTLSSDLS*QRA**I YGISVHQRYTR*ELFQGHFIR*FWT*RF*KYILP LPVQN*WPRKKTHPWH*CAF*EEDLGFIHGLAL YS*QRLLFRRDCHISSLSP*GSNSADFNYS*KK GGKILRWKYSLGYLWPSENGSNISHSRIAHLLSN IKCFGPNPRETKETSGSEGSHECRRTSSKIQNL SW*CL*YLQ*KSIYYFL*IRFQTSEKK*SLKEV *IQQWSPRGR*NLKSRPVTETEQTI*NTL*RQLN *SRDHAKTARGRTDAATSQNGP*TVSVEPISRR HNQSVHA*HHQGSVKRNCPRNSHDSKKTEEFLW P*VCENDN*TIYIFGFATVYSY*EREE*G*PKES KHNASERAKTGTDL*YQNYM*RCV*YGCGTYWL SRASFVCFSYPQR**IFLC*S*LKINQSGPRGM ERRTKEKDQSHC*FYFVFQN*IFYG*C*SNTTYS DVSSVLPSASKRYFGGKDAL***DFLIAGILGS PG*VWRLSTRGSWCVLL*NGALFARQSDGET*F ILYQRRVTQIA*YLCGSF*KRDRVRIFKGLPKTD RIWSSFSPSAP*EEVTNRNIAWSLF*RCPCV*S SQWSAHIGPSLSMEGNQENIFF*KENHIAKYIR WNKTWLPDRQQ*DMPVPAAPLLLPA*VPATDESK TEQPRCPRY*ESFV*EPESPSRVC*RI*YGTSN QHWQSGQQHPQQTCCSTFISSS*DSEEAILLRA VALPAIAKQFKREE*QSFMGGKA*RDE*IIP*SQ SGLSLSTSEKCHC*HGTPTTNRCRVGGKTFSPD VKI*CRIFGRSDKT**FKVCCEFK*KS*KEET* IRLLIH*RPWASICSRCATQKMEHSIFTRKGDHL SEPEKRCKVWLGISNYWWGEDGKTGPRHIYQFS CPWRTS*LGWMLEARRPFDICE*CESGGSQPPC CN*NFAKCT*RCDTCYLSAKRKDIQSAFYSCASH Q*DEKLHEEIFLHARQCYRFFFQGSPLVTWYPE AHLGELLWAIWGPAGRKPEFSRFQD*ECQLVSK PGQWFLCQPFR*PNLAGITAWQPFPICNIQSHRE RDFH***PKQN*KARHF*CN*LLRPWRFRHG*S HLLQQSGSSNTKTGIFLFSEYIQQDEF*NFFFI TS*AWRYL*G*TG*K**QLGDKCHGRCEYECQTW WHLCESCYSPGSSRV*W*NSQR*SRPSCQWS*S RRSHP*ASCGNTEKYRTGGSSVIRKGTISNI*R TCPGNPTVYPFRSECPRSRPRKSEENNSGQRLQL CH*RKYI*GKII*K*LRSRIQFFSRR*SYTGAN *CQHSKG*KALSWTASSRKWKN*CRRCYLESEW SLFERTISAGSHICSQGNCSRSILASLQTSTWCA TGN*YCAFDPTSVSSTSTSKQQ*RLFSAIMCGA KHQLR*K*NVRQKQKTVQVPIQKRQLQ*QQWEW RR*LSDSSSKHIKFDLEFSFASDSKQHGITGTES S*STQESRRYHLYHVLLSSENSQ*TRV*GQ*SF PSTTGYGSWAELSTPIRICFL*FDG*VSYTSHF *TN*TRKLDTFEK*LGKSP*RL*TGSRTPHYPN* IRKRKPGFYSNQRQSENWLLCS*CHTGSSQK*W KAKTWGPAHKG**YRCY*YDSYRCS*SAPGCIQ NSQISYWTSSRITQNTNVASFATGHNTNVQQRGV GFFLMWRS*QPLSSGIY**Y*SKVRRSH*G*SP AIRCHPLCERSQHTRNDLGGS*QSIRHVTSFIG IESNKK*SSSGPQLKEVCCFSSKVNQRQWFLQCG VLQPACPHS**FILHGCWGRNK*NIVPQRKMFY LSDKGITKLDSAQRILYTRR*HL**FPRS*SYP VSAGCCG*GSPESFKRK*CSRILLWSRYIKDEWE VIRRENRRYRLRWFTFT*VFY*GHQNEWL*RIL *RKSKK*KLNSEATRKED****NNMGK**VANR ENKP*RF**RSFLSDKR*ARCTPCRQSASLW*IH GCQLKISHSSPAGFARSRNSF*GAGESSRIKTF GSVSNWAN*GKQKEEQI*KYTSL*CYKSASWR* RWLYQCQLH*DTSWERRVRLHCLPRTTAYNCWRL LADDLGAKIHSDSHDDSRSRRRKNQMPALLAQH PRQNNNGQQQTSTGSCENAAAEGLCGEGNDP*R YSDQRGAPYFSSEFHCLARP*YTFSTR*SAYFYL LHETHPQIRPNHYALQCWHWTFRDPDLHRCGSG INQSGS*F*HL*FGALHETTKTRNGSDRGSIYF LLSSHPLCPDTSSSRRRAKTAASASEVT*KEPLD AFPFLSLTSSRLLLSIQNKDHRAASSYNMHVLL YLRGVFFLKIKNIEMLYFYSYFNL**LFTKF*H *PNNADLRDD*RQHLMIADIVTRTW*VYF*CTNL VYSKNVFQYFNKVVIL*GILETSI*ALNDSNIG IEKSSKCLLYQFLMFTI*NFL*YIYILFHENGV ISYLFVTASSVCNHYLTL*IKTHLKT*TSQNCVQ

Sequence PTPN13.aAug05

GAGTAGCTCCAGCGGCCACGCTGAGGCGAGGGTGACACACCATGCTCACGGCCCCTGGAGACCGTCGTGCTGGCGAGCCGTGCTCCGTAGCTCCCCGGTC CGCCTCGGCAGCGGTCAGAGTCGCCTACAGGAGTTGAGCCGCCCGCGCCAGAAGGTTTTGGCGAAGCTCTTGGAGAGGCGTCGAGCACAGTAGGGCGGCG GGGGTGCGTTGAGCGCTCGGGGGTCAGGCAGTCGGCCGGGATCGCCGCTGGGGAGCGTTTCCGAGGCGAGGAGGAGGAGGAGGAGATGCTGCTCCTCTTC TCCCCCTCCCCAGGCTCCTTCTACAGCTCCTTCAGCCCACGCCCGCAGCCGCTTGTGGGAGAAGTGGTGGTGGCTCTCGGCGCCCGCGGCGGCTGCCGGC GGCCCGCCCCGACGCCGCGTCCCTGCAGCCCTCGCCCGGCGCTCCAGTAGCAGGACCCGGTCTCGGGACCAGCCGGTAATATGCACGTGTCACTAGCTGA GGCCCTGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTGTATTAAATCAAAGTGCTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGC CTAGCTGATCCTGCTGCCCTTGGCTTCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTTACAGATGAAAATATTTCCAATC AGGATCTTCGAGCATTCACTGCACCAGAGGTTCTTCAAAATCAGTCACTAACTTCTCTCTCAGATGTTGAAAAGATCCACATTTATTCTCTTGGAATGAC ACTGTATTGGGGGGCTGATTATGAAGTGCCTCAGAGCCAACCTATTAAGCTTGGAGATCATCTCAACAGCATACTGCTTGGAATGTGTGAGGATGTTATT TACGCTCGAGTTTCTGTTCGGACTGTGCTGGATGCTTGCAGTGCCCACATTAGGAATAGCAATTGTGCACCCTCATTTTCCTACGTGAAACACTTGGTAA AACTGGTTCTGGGAAATCTTTCTGGGACAGATCAGCTTTCCTGTAACAGTGAACAAAAGCCTGATCGAAGCCAGGCTATTCGAGATCGATTGCGAGGAAA AGGATTACCAACAGGAAGAAGCTCTACTTCTGATGTACTAGACATACAAAAGCCTCCACTCTCTCATCAGACCTTTCTTAACAAAGGGCTTAGTAAATCT ATGGGATTTCTGTCCATCAAAGATACACAAGATGAGAATTATTTCAAGGACATTTTATCAGATAATTCTGGACGTGAAGATTCTGAAAATACATTCTCCC CTTACCAGTTCAAAACTAGTGGCCCAGAAAAAAAACCCATCCCTGGCATTGATGTGCTTTCTAAGAAGAAGATCTGGGCTTCATCCATGGACTTGCTTTG TACAGCTGACAGAGACTTCTCTTCAGGAGAGACTGCCACATATCGTCGTTGTCACCCTGAGGCAGTAACAGTGCGGACTTCAACTACTCCTAGAAAAAAG GAGGCAAGATACTCAGATGGAAGTATAGCCTTGGATATCTTTGGCCCTCAGAAAATGGATCCAATATATCACACTCGAGAATTGCCCACCTCCTCAGCAA TATCAAGTGCTTTGGACCGAATCCGAGAGAGACAAAAGAAACTTCAGGTTCTGAGGGAAGCCATGAATGTAGAAGAACCAGTTCGAAGATACAAAACTTA TCATGGTGATGTCTTTAGTACCTCCAGTGAAAGTCCATCTATTATTTCCTCTGAATCAGATTTCAGACAAGTGAGAAGAAGTGAAGCCTCAAAGAGGTTT GAATCCAGCAGTGGTCTCCCAGGGGTAGATGAAACCTTAAGTCAAGGCCAGTCACAGAGACCGAGCAGACAATATGAAACACCCTTTGAAGGCAACTTAA TTAATCAAGAGATCATGCTAAAACGGCAAGAGGAAGAACTGATGCAGCTACAAGCCAAAATGGCCCTTAGACAGTCTCGGTTGAGCCTATATCCAGGAGA CACAATCAAAGCGTCCATGCTTGACATCACCAGGGATCCGTTAAGAGAAATTGCCCTAGAAACAGCCATGACTCAAAGAAAACTGAGGAATTTCTTTGGC CCTGAGTTTGTGAAAATGACAATTGAACCATTTATATCTTTGGATTTGCCACGGTCTATTCTTACTAAGAAAGGGAAGAATGAGGATAACCGAAGGAAAG TAAACATAATGCTTCTGAACGGGCAAAGACTGGAACTGACCTGTGATACCAAAACTATATGTAAAGATGTGTTTGATATGGTTGTGGCACATATTGGCTT AGTAGAGCATCATTTGTTTGCTTTAGCTACCCTCAAAGATAATGAATATTTCTTTGTTGATCCTGACTTAAAATTAACCAAAGTGGCCCCAGAGGGATGG AAAGAAGAACCAAAGAAAAAGACCAAAGCCACTGTTAATTTTACTTTGTTTTTCAGAATTAAATTTTTTATGGATGATGTTAGTCTAATACAACATACTC TGACGTGTCATCAGTATTACCTTCAGCTTCGAAAAGATATTTTGGAGGAAAGGATGCACTGTGATGATGAGACTTCCTTATTGCTGGCATCCTTGGCTCT CCAGGCTGAGTATGGAGATTATCAACCAGAGGTTCATGGTGTGTCTTACTTTAGAATGGAGCACTATTTGCCCGCCAGAGTGATGGAGAAACTTGATTTA TCCTATATCAAAGAAGAGTTACCCAAATTGCATAATACCTATGTGGGAGCTTCTGAAAAAGAGACAGAGTTAGAATTTTTAAAGGTCTGCCAAAGACTGA CAGAATATGGAGTTCATTTTCACCGAGTGCACCCTGAGAAGAAGTCACAAACAGGAATATTGCTTGGAGTCTGTTCTAAAGGTGTCCTTGTGTTTGAAGT TCACAATGGAGTGCGCACATTGGTCCTTCGCTTTCCATGGAGGGAAACCAAGAAAATATCTTTTTCTAAAAAGAAAATCACATTGCAAAATACATCAGAT GGAATAAAACATGGCTTCCAGACAGACAACAGTAAGATATGCCAGTACCTGCTGCACCTCTGCTCTTACCAGCATAAGTTCCAGCTACAGATGAGAGCAA GACAGAGCAACCAAGATGCCCAAGATATTGAGAGAGCTTCGTTTAGGAGCCTGAATCTCCAAGCAGAGTCTGTTAGAGGATTTAATATGGGACGAGCAAT CAGCACTGGCAGTCTGGCCAGCAGCACCCTCAACAAACTTGCTGTTCGACCTTTATCAGTTCAAGCTGAGATTCTGAAGAGGCTATCCTGCTCAGAGCTG TCGCTTTACCAGCCATTGCAAAACAGTTCAAAAGAGAAGAATGACAAAGCTTCATGGGAGGAAAAGCCTAGAGAGATGAGTAAATCATACCATGATCTCA GTCAGGCCTCTCTCTATCCACATCGGAAAAATGTCATTGTTAACATGGAACCCCCACCACAAACCGTTGCAGAGTTGGTGGGAAAACCTTCTCACCAGAT GTCAAGATCTGATGCAGAATCTTTGGCAGGAGTGACAAAACTTAATAATTCAAAGTCTGTTGCGAGTTTAAATAGAAGTCCTGAAAGGAGGAAACATGAA TCAGACTCCTCATCCATTGAAGACCCTGGGCAAGCATATGTTCTAGGAATGACTATGCATAGTTCTGGAAACTCTTCATCCCAAGTACCCTTAAAAGAAA ATGATGTGCTACACAAAAGATGGAGCATAGTATCTTCACCAGAAAGGGAGATCACCTTAGTGAACCTGAAAAAAGATGCAAAGTATGGCTTGGGATTTCA AATTATTGGTGGGGAGAAGATGGGAAGACTGGACCTAGGCATATTTATCAGTTCAGTTGCCCCTGGAGGACCAGCTGACTTGGATGGATGCTTGAAGCCA GGAGACCGTTTGATATCTGTGAATAGTGTGAGTCTGGAGGGAGTCAGCCACCATGCTGCAATTGAAATTTTGCAAAATGCACCTGAAGATGTGACACTTG TTATCTCTCAGCCAAAAGAAAAGATATCCAAAGTGCCTTCTACTCCTGTGCATCTCACCAATGAGATGAAAAACTACATGAAGAAATCTTCCTACATGCA AGACAGTGCTATAGATTCTTCTTCCAAGGATCACCACTGGTCACGTGGTACCCTGAGGCACATCTCGGAGAACTCCTTTGGGCCATCTGGGGGCCTGCGG GAAGGAAGCCTGAGTTCTCAAGATTCCAGGACTGAGAGTGCCAGCTTGTCTCAAAGCCAGGTCAATGGTTTCTTTGCCAGCCATTTAGGTGACCAAACCT GGCAGGAATCACAGCATGGCAGCCCTTCCCCATCTGTAATATCCAAAGCCACCGAGAAAGAGACTTTCACTGATAGTAACCAAAGCAAAACTAAAAAGCC AGGCATTTCTGATGTAACTGATTACTCAGACCGTGGAGATTCAGACATGGATGAAGCCACTTACTCCAGCAGTCAGGATCATCAAACACCAAAACAGGAA TCTTCCTCTTCAGTGAATACATCCAACAAGATGAATTTTAAAACTTTTTCTTCATCACCTCCTAAGCCTGGAGATATCTTTGAGGTTGAACTGGCTAAAA ATGATAACAGCTTGGGGATAAGTGTCACGGTACTGTTTGACAAGGGAGGTGTGAATACGAGTGTCAGACATGGTGGCATTTATGTGAAAGCTGTTATTCC CCAGGGAGCAGCAGAGTCTGATGGTAGAATTCACAAAGGTGATCGCGTCCTAGCTGTCAATGGAGTTAGTCTAGAAGGAGCCACCCATAAGCAAGCTGTG GAAACACTGAGAAATACAGGACAGGTGGTTCATCTGTTATTAGAAAAGGGACAATCTCCAACATCTAAAGAACATGTCCCGGTAACCCCACAGTGTACCC TTTCAGATCAGAATGCCCAAGGTCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAGGTCAAAGACTACAGCTTTGTCACTGAAGAAAATACATTTGAGGT AAAATTATTTAAAAATAGCTCAGGTCTAGGATTCAGTTTTTCTCGAGAAGATAATCTTATACCGGAGCAAATTAATGCCAGCATAGTAAGGGTTAAAAAG CTCTTTCCTGGACAGCCAGCAGCAGAAAGTGGAAAAATTGATGTAGGAGATGTTATCTTGAAAGTGAATGGAGCCTCTTTGAAAGGACTATCTCAGCAGG AAGTCATATCTGCTCTCAGGGGAACTGCTCCAGAAGTATTCTTGCTTCTCTGCAGACCTCCACCTGGTGTGCTACCGGAAATTGATACTGCGCTTTTGAC CCCACTTCAGTCTCCAGCACAAGTACTTCCAAACAGCAGTAAAGACTCTTCTCAGCCATCATGTGTGGAGCAAAGCACCAGCTCAGATGAAAATGAAATG TCAGACAAAAGCAAAAAACAGTGCAAGTCCCCATCCAGAAGAGACAGTTACAGTGACAGCAGTGGGAGTGGAGAAGATGACTTAGTGACAGCTCCAGCAA ACATATCAAATTCGACCTGGAGTTCAGCTTTGCATCAGACTCTAAGCAACATGGTATCACAGGCACAGAGTCATCATGAAGCACCCAAGAGTCAAGAAGA TACCATTTGTACCATGTTTTACTATCCTCAGAAAATTCCCAATAAACCAGAGTTTGAGGACAGTAATCCTTCCCCTCTACCACCGGATATGGCTCCTGGG CAGAGTTATCAACCCCAATCAGAATCTGCTTCCTCTAGTTCGATGGATAAGTATCATATACATCACATTTCTGAACCAACTAGACAAGAAAACTGGACAC CTTTGAAAAATGACTTGGAAAATCACCTTGAAGACTTTGAACTGGAAGTAGAACTCCTCATTACCCTAATTAAATCAGAAAAAGGAAGCCTGGGTTTTAC AGTAACCAAAGGCAATCAGAGAATTGGTTGTTATGTTCATGATGTCATACAGGATCCAGCCAAAAGTGATGGAAGGCTAAAACCTGGGGACCGGCTCATA AAGGTTAATGATACAGATGTTACTAATATGACTCATACAGATGCAGTTAATCTGCTCCGGGCTGCATCCAAAACAGTCAGATTAGTTATTGGACGAGTTC TAGAATTACCCAGAATACCAATGTTGCCTCATTTGCTACCGGACATAACACTAACGTGCAACAAAGAGGAGTTGGGTTTTTCCTTATGTGGAGGTCATGA CAGCCTTTATCAAGTGGTATATATTAGTGATATTAATCCAAGGTCCGTCGCAGCCATTGAGGGTAATCTCCAGCTATTAGATGTCATCCATTATGTGAAC GGAGTCAGCACACAAGGAATGACCTTGGAGGAAGTTAACAGAGCATTAGACATGTCACTTCCTTCATTGGTATTGAAAGCAACAAGAAATGATCTTCCAG TGGTCCCCAGCTCAAAGAGGTCTGCTGTTTCAGCTCCAAAGTCAACCAAAGGCAATGGTTCCTACAGTGTGGGGTCTTGCAGCCAGCCTGCCCTCACTCC TAATGATTCATTCTCCACGGTTGCTGGGGAAGAAATAAATGAAATATCGTACCCCAAAGGAAAATGTTCTACTTATCAGATAAAGGGATCACCAAACTTG ACTCTGCCCAAAGAATCTTATATACAAGAAGATGACATTTATGATGATTCCCAAGAAGCTGAAGTTATCCAGTCTCTGCTGGATGTTGTGGATGAGGAAG CCCAGAATCTTTTAAACGAAAATAATGCAGCAGGATACTCCTGTGGTCCAGGTACATTAAAGATGAATGGGAAGTTATCAGAAGAGAGAACAGAAGATAC AGACTGCGATGGTTCACCTTTACCTGAGTATTTTACTGAGGCCACCAAAATGAATGGCTGTGAAGAATATTGTGAAGAAAAAGTAAAAAGTGAAAGCTTA ATTCAGAAGCCACAAGAAAAGAAGACTGATGATGATGAAATAACATGGGGAAATGATGAGTTGCCAATAGAGAGAACAAACCATGAAGATTCTGATAAAG ATCATTCCTTTCTGACAAACGATGAGCTCGCTGTACTCCCTGTCGTCAAAGTGCTTCCCTCTGGTAAATACACGGGTGCCAACTTAAAATCAGTCATTCG AGTCCTGCGGGGTTTGCTAGATCAAGGAATTCCTTCTAAGGAGCTGGAGAATCTTCAAGAATTAAAACCTTTGGATCAGTGTCTAATTGGGCAAACTAAG GAAAACAGAAGGAAGAACAGATATAAAAATATACTTCCCTATGATGCTACAAGAGTGCCTCTTGGAGATGAAGGTGGCTATATCAATGCCAGCTTCATTA AGATACCAGTTGGGAAAGAAGAGTTCGTTTACATTGCCTGCCAAGGACCACTGCCTACAACTGTTGGAGACTTCTGGCAGATGATTTGGGAGCAAAAATC CACAGTGATAGCCATGATGACTCAAGAAGTAGAAGGAGAAAAAATCAAATGCCAGCGCTATTGGCCCAACATCCTAGGCAAAACAACAATGGTCAGCAAC AGACTTCGACTGGCTCTTGTGAGAATGCAGCAGCTGAAGGGCTTTGTGGTGAGGGCAATGACCCTTGAAGATATTCAGACCAGAGAGGTGCGCCATATTT CTCATCTGAATTTCACTGCCTGGCCAGACCATGATACACCTTCTCAACCAGATGATCTGCTTACTTTTATCTCCTACATGAGACACATCCACAGATCAGG CCCAATCATTACGCACTGCAGTGCTGGCATTGGACGTTCAGGGACCCTGATTTGCATAGATGTGGTTCTGGGATTAATCAGTCAGGATCTTGATTTTGAC ATCTCTGATTTGGTGCGCTGCATGAGACTACAAAGACACGGAATGGTTCAGACAGAGGATCAATATATTTTCTGCTATCAAGTCATCCTTTATGTCCTGA CACGTCTTCAAGCAGAAGAAGAGCAAAAACAGCAGCCTCAGCTTCTGAAGTGACATGAAAAGAGCCTCTGGATGCATTTCCATTTCTCTCCTTAACCTCC AGCAGACTCCTGCTCTCTATCCAAAATAAAGATCACAGAGCAGCAAGTTCATACAACATGCATGTTCTCCTCTATCTTAGAGGGGTATTCTTCTTGAAAA TAAAAAATATTGAAATGCTGTATTTTTACAGCTACTTTAACCTATGATAATTATTTACAAAATTTTAACACTAACCAAACAATGCAGATCTTAGGGATGA TTAAAGGCAGCATTTGATGATAGCAGACATTGTTACAAGGACATGGTGAGTCTATTTTTAATGCACCAATCTTGTTTATAGCAAAAATGTTTTCCAATAT TTTAATAAAGTAGTTATTTTATAGGGGATACTTGAAACCAGTATTTAAGCTTTAAATGACAGTAATATTGGCATAGAAAAAAGTAGCAAATGTTTACTGT ATCAATTTCTAATGTTTACTATATAGAATTTCCTGTAATATATTTATATACTTTTTCATGAAAATGGAGTTATCAGTTATCTGTTTGTTACTGCATCATC TGTTTGTAATCATTATCTCACTTTGTAAATAAAAACACACCTTAAAACATGAACAAGCCAAAACTGTGTGCAGAC

PTPN13.F7 (forward primer)
PTPN13.R7 (reverse primer)
Single exon skipping

Frame 0

E*LQRPR*GEGDTPCSRPLETVVLASRAP*LPG PPRQRSESPTGVEPPAPEGFGEALGEASSTVGRR GCVERSGVRQSAGIAAGERFRGEEEEEEMLLLF SPSPGSFYSSFSPRPQPLVGEVVVALGARGGCR RPAPTPRPCSPRPALQ*QDPVSGPAGNMHVSLAE ALEVRGGPLQEEEIWAVLNQSAESLQELFRKVS LADPAALGFIISPWSLLLLPSGSVSFTDENISN QDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMT LYWGADYEVPQSQPIKLGDHLNSILLGMCEDVI YARVSVRTVLDACSAHIRNSNCAPSFSYVKHLV KLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGK GLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS MGFLSIKDTQDENYFKDILSDNSGREDSENTFS PYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLC TADRDFSSGETATYRRCHPEAVTVRTSTTPRKK EARYSDGSIALDIFGPQKMDPIYHTRELPTSSA ISSALDRIRERQKKLQVLREAMNVEEPVRRYKTY HGDVFSTSSESPSIISSESDFRQVRRSEASKRF ESSSGLPGVDETLSQGQSQRPSRQYETPFEGNL INQEIMLKRQEEELMQLQAKMALRQSRLSLYPGD TIKASMLDITRDPLREIALETAMTQRKLRNFFG PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRK VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGL VEHHLFALATLKDNEYFFVDPDLKLTKVAPEGW KEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHT LTCHQYYLQLRKDILEERMHCDDETSLLLASLAL QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL SYIKEELPKLHNTYVGASEKETELEFLKVCQRL TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEV HNGVRTLVLRFPWRETKKISFSKKKITLQNTSD GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRA RQSNQDAQDIERASFRSLNLQAESVRGFNMGRAI STGSLASSTLNKLAVRPLSVQAEILKRLSCSEL SLYQPLQNSSKEKNDKASWEEKPREMSKSYHDL SQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQM SRSDAESLAGVTKLNNSKSVASLNRSPERRKHE SDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKE NDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQ IIGGEKMGRLDLGIFISSVAPGGPADLDGCLKP GDRLISVNSVSLEGVSHHAAIEILQNAPEDVTL VISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLR EGSLSSQDSRTESASLSQSQVNGFFASHLGDQT WQESQHGSPSPSVISKATEKETFTDSNQSKTKKP GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQE SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK NDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIP QGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV ETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT LSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEV KLFKNSSGLGFSFSREDNLIPEQINASIVRVKK LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQ EVISALRGTAPEVFLLLCRPPPGVLPEIDTALLT PLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEM SDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPA NISNSTWSSALHQTLSNMVSQAQSHHEAPKSQED TICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPG QSYQPQSESASSSSMDKYHIHHISEPTRQENWT PLKNDLENHLEDFELEVELLITLIKSEKGSLGFT VTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLI KVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV LELPRIPMLPHLLPDITLTCNKEELGFSLCGGHD SLYQVVYISDINPRSVAAIEGNLQLLDVIHYVN GVSTQGMTLEEVNRALDMSLPSLVLKATRNDLP VVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP NDSFSTVAGEEINEISYPKGKCSTYQIKGSPNL TLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEE AQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDT DCDGSPLPEYFTEATKMNGCEEYCEEKVKSESL IQKPQEKKTDDDEITWGNDELPIERTNHEDSDK DHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIR VLRGLLDQGIPSKELENLQELKPLDQCLIGQTK ENRRKNRYKNILPYDATRVPLGDEGGYINASFI KIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKS TVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSN RLRLALVRMQQLKGFVVRAMTLEDIQTREVRHI SHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG PIITHCSAGIGRSGTLICIDVVLGLISQDLDFD ISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL TRLQAEEEQKQQPQLLK*HEKSLWMHFHFSP*PP ADSCSLSKIKITEQQVHTTCMFSSILEGYSS*K *KILKCCIFTATLTYDNYLQNFNTNQTMQILGM IKGSI***QTLLQGHGESIFNAPILFIAKMFSNI LIK*LFYRGYLKPVFKL*MTVILA*KKVANVYC INF*CLLYRISCNIFIYFFMKMELSVICLLLHH LFVIIISLCK*KHTLKHEQAKTVCR

Frame 1

SSSSGHAEARVTHHAHGPWRPSCWRAVLRSSPV RLGSGQSRLQELSRPRQKVLAKLLERRRAQ*GG GGALSARGSGSRPGSPLGSVSEARRRRRRCCSSS PPPQAPSTAPSAHARSRLWEKWWWLSAPAAAAG GPPRRRVPAALARRSSSRTRSRDQPVICTCH*L RPWRFGVDHFRRKKYGLY*IKVLKVSKNYSEK*A *LILLPLASSFLHGLCCCCHLVVCHLQMKIFPI RIFEHSLHQRFFKISH*LLSQMLKRSTFILLE* HCIGGLIMKCLRANLLSLEIISTAYCLECVRMLF TLEFLFGLCWMLAVPTLGIAIVHPHFPT*NTW* NWFWEIFLGQISFPVTVNKSLIEARLFEIDCEE KDYQQEEALLLMY*TYKSLHSLIRPFLTKGLVNL WDFCPSKIHKMRIISRTFYQIILDVKILKIHSP LTSSKLVAQKKNPSLALMCFLRRRSGLHPWTCF VQLTETSLQERLPHIVVVTLRQ*QCGLQLLLEKR RQDTQMEV*PWISLALRKWIQYITLENCPPPQQ YQVLWTESERDKRNFRF*GKP*M*KNQFEDTKL IMVMSLVPPVKVHLLFPLNQISDK*EEVKPQRGL NPAVVSQG*MKP*VKASHRDRADNMKHPLKAT* LIKRSC*NGKRKN*CSYKPKWPLDSLG*AYIQE TQSKRPCLTSPGIR*EKLP*KQP*LKEN*GISLA LSL*K*QLNHLYLWICHGLFLLRKGRMRITEGK *T*CF*TGKDWN*PVIPKLYVKMCLIWLWHILA **SIICLL*LPSKIMNISLLILT*N*PKWPQRDG KKNQRKRPKPLLILLCFSELNFLWMMLV*YNIL *RVISITFSFEKIFWRKGCTVMMRLPYCWHPWL SRLSMEIINQRFMVCLTLEWSTICPPE*WRNLIY PISKKSYPNCIIPMWELLKKRQS*NF*RSAKD* QNMEFIFTECTLRRSHKQEYCLESVLKVSLCLK FTMECAHWSFAFHGGKPRKYLFLKRKSHCKIHQM E*NMASRQTTVRYASTCCTSALTSISSSYR*EQ DRATKMPKILRELRLGA*ISKQSLLEDLIWDEQ SALAVWPAAPSTNLLFDLYQFKLRF*RGYPAQSC RFTSHCKTVQKRRMTKLHGRKSLER*VNHTMIS VRPLSIHIGKMSLLTWNPHHKPLQSWWENLLTR CQDLMQNLWQE*QNLIIQSLLRV*IEVLKGGNMN QTPHPLKTLGKHMF*E*LCIVLETLHPKYP*KK MMCYTKDGA*YLHQKGRSP**T*KKMQSMAWDF KLLVGRRWEDWT*AYLSVQLPLEDQLTWMDA*SQ ETV*YL*IV*VWRESATMLQLKFCKMHLKM*HL LSLSQKKRYPKCLLLLCISPMR*KTT*RNLPTC KTVL*ILLPRITTGHVVP*GTSRRTPLGHLGACG KEA*VLKIPGLRVPACLKARSMVSLPAI*VTKP GRNHSMAALPHL*YPKPPRKRLSLIVTKAKLKS QAFLM*LITQTVEIQTWMKPLTPAVRIIKHQNRN LPLQ*IHPTR*ILKLFLHHLLSLEISLRLNWLK MITAWG*VSRYCLTREV*IRVSDMVAFM*KLLF PREQQSLMVEFTKVIAS*LSMELV*KEPPISKLW KH*EIQDRWFICY*KRDNLQHLKNMSR*PHSVP FQIRMPKVKAQKK*RKQLRSKTTALSLKKIHLR *NYLKIAQV*DSVFLEKIILYRSKLMPA**GLKS SFLDSQQQKVEKLM*EMLS*K*MEPL*KDYLSR KSYLLSGELLQKYSCFSADLHLVCYRKLILRF* PHFSLQHKYFQTAVKTLLSHHVWSKAPAQMKMKC QTKAKNSASPHPEETVTVTAVGVEKMT**QLQQ TYQIRPGVQLCIRL*ATWYHRHRVIMKHPRVKK IPFVPCFTILRKFPINQSLRTVILPLYHRIWLLG RVINPNQNLLPLVRWISIIYITFLNQLDKKTGH L*KMTWKITLKTLNWK*NSSLP*LNQKKEAWVL Q*PKAIRELVVMFMMSYRIQPKVMEG*NLGTGS* RLMIQMLLI*LIQMQLICSGLHPKQSD*LLDEF *NYPEYQCCLICYRT*H*RATKRSWVFPYVEVM TAFIKWYILVILIQGPSQPLRVISSY*MSSIM*T ESAHKE*PWRKLTEH*TCHFLHWY*KQQEMIFQ WSPAQRGLLFQLQSQPKAMVPTVWGLAASLPSL LMIHSPRLLGKK*MKYRTPKENVLLIR*RDHQT* LCPKNLIYKKMTFMMIPKKLKLSSLCWMLWMRK PRIF*TKIMQQDTPVVQVH*R*MGSYQKREQKI QTAMVHLYLSILLRPPK*MAVKNIVKKK*KVKA* FRSHKKRRLMMMK*HGEMMSCQ*REQTMKILIK IIPF*QTMSSLYSLSSKCFPLVNTRVPT*NQSF ESCGVC*IKEFLLRSWRIFKN*NLWISV*LGKLR KTEGRTDIKIYFPMMLQECLLEMKVAISMPASL RYQLGKKSSFTLPAKDHCLQLLETSGR*FGSKN PQ**P**LKK*KEKKSNASAIGPTS*AKQQWSAT DFDWLL*ECSS*RALW*GQ*PLKIFRPERCAIF LI*ISLPGQTMIHLLNQMICLLLSPT*DTSTDQ AQSLRTAVLALDVQGP*FA*MWFWD*SVRILILT SLIWCAA*DYKDTEWFRQRINIFSAIKSSFMS* HVFKQKKSKNSSLSF*SDMKRASGCISISLLNL QQTPALYPK*RSQSSKFIQHACSPLS*RGILLEN KKY*NAVFLQLL*PMIIIYKILTLTKQCRS*G* LKAAFDDSRHCYKDMVSLFLMHQSCL*QKCFPI F**SSYFIGDT*NQYLSFK*Q*YWHRKK*QMFTV SISNVYYIEFPVIYLYTFS*KWSYQLSVCYCII CL*SLSHFVNKNTP*NMNKPKLCAD

Frame 2

VAPAATLRRG*HTMLTAPGDRRAGEPCSVAPRS ASAAVRVAYRS*AARARRFWRSSWRGVEHSRAA GVR*ALGGQAVGRDRRWGAFPRRGGGGGDAAPL LPLPRLLLQLLQPTPAAACGRSGGGSRRPRRLPA ARPDAASLQPSPGAPVAGPGLGTSR*YARVTS* GPGGSGWTTSGGRNMGCIKSKC*KSPRIIQKSK PS*SCCPWLHHFSMVSAVAAIW*CVIYR*KYFQS GSSSIHCTRGSSKSVTNFSLRC*KDPHLFSWND TVLGG*L*SASEPTY*AWRSSQQHTAWNV*GCY LRSSFCSDCAGCLQCPH*E*QLCTLIFLRETLGK TGSGKSFWDRSAFL*Q*TKA*SKPGYSRSIARK RITNRKKLYF*CTRHTKASTLSSDLS*QRA**I YGISVHQRYTR*ELFQGHFIR*FWT*RF*KYILP LPVQN*WPRKKTHPWH*CAF*EEDLGFIHGLAL YS*QRLLFRRDCHISSLSP*GSNSADFNYS*KK GGKILRWKYSLGYLWPSENGSNISHSRIAHLLSN IKCFGPNPRETKETSGSEGSHECRRTSSKIQNL SW*CL*YLQ*KSIYYFL*IRFQTSEKK*SLKEV *IQQWSPRGR*NLKSRPVTETEQTI*NTL*RQLN *SRDHAKTARGRTDAATSQNGP*TVSVEPISRR HNQSVHA*HHQGSVKRNCPRNSHDSKKTEEFLW P*VCENDN*TIYIFGFATVYSY*EREE*G*PKES KHNASERAKTGTDL*YQNYM*RCV*YGCGTYWL SRASFVCFSYPQR**IFLC*S*LKINQSGPRGM ERRTKEKDQSHC*FYFVFQN*IFYG*C*SNTTYS DVSSVLPSASKRYFGGKDAL***DFLIAGILGS PG*VWRLSTRGSWCVLL*NGALFARQSDGET*F ILYQRRVTQIA*YLCGSF*KRDRVRIFKGLPKTD RIWSSFSPSAP*EEVTNRNIAWSLF*RCPCV*S SQWSAHIGPSLSMEGNQENIFF*KENHIAKYIR WNKTWLPDRQQ*DMPVPAAPLLLPA*VPATDESK TEQPRCPRY*ESFV*EPESPSRVC*RI*YGTSN QHWQSGQQHPQQTCCSTFISSS*DSEEAILLRA VALPAIAKQFKREE*QSFMGGKA*RDE*IIP*SQ SGLSLSTSEKCHC*HGTPTTNRCRVGGKTFSPD VKI*CRIFGRSDKT**FKVCCEFK*KS*KEET* IRLLIH*RPWASICSRNDYA*FWKLFIPSTLKRK *CATQKMEHSIFTRKGDHLSEPEKRCKVWLGIS NYWWGEDGKTGPRHIYQFSCPWRTS*LGWMLEA RRPFDICE*CESGGSQPPCCN*NFAKCT*RCDTC YLSAKRKDIQSAFYSCASHQ*DEKLHEEIFLHA RQCYRFFFQGSPLVTWYPEAHLGELLWAIWGPA GRKPEFSRFQD*ECQLVSKPGQWFLCQPFR*PNL AGITAWQPFPICNIQSHRERDFH***PKQN*KA RHF*CN*LLRPWRFRHG*SHLLQQSGSSNTKTG IFLFSEYIQQDEF*NFFFITS*AWRYL*G*TG*K **QLGDKCHGTV*QGRCEYECQTWWHLCESCYS PGSSRV*W*NSQR*SRPSCQWS*SRRSHP*ASC GNTEKYRTGGSSVIRKGTISNI*RTCPGNPTVYP FRSECPRSRPRKSEENNSGQRLQLCH*RKYI*G KII*K*LRSRIQFFSRR*SYTGAN*CQHSKG*K ALSWTASSRKWKN*CRRCYLESEWSLFERTISAG SHICSQGNCSRSILASLQTSTWCATGN*YCAFD PTSVSSTSTSKQQ*RLFSAIMCGAKHQLR*K*N VRQKQKTVQVPIQKRQLQ*QQWEWRR*LSDSSSK HIKFDLEFSFASDSKQHGITGTESS*STQESRR YHLYHVLLSSENSQ*TRV*GQ*SFPSTTGYGSW AELSTPIRICFL*FDG*VSYTSHF*TN*TRKLDT FEK*LGKSP*RL*TGSRTPHYPN*IRKRKPGFY SNQRQSENWLLCS*CHTGSSQK*WKAKTWGPAH KG**YRCY*YDSYRCS*SAPGCIQNSQISYWTSS RITQNTNVASFATGHNTNVQQRGVGFFLMWRS* QPLSSGIY**Y*SKVRRSH*G*SPAIRCHPLCE RSQHTRNDLGGS*QSIRHVTSFIGIESNKK*SSS GPQLKEVCCFSSKVNQRQWFLQCGVLQPACPHS **FILHGCWGRNK*NIVPQRKMFYLSDKGITKL DSAQRILYTRR*HL**FPRS*SYPVSAGCCG*GS PESFKRK*CSRILLWSRYIKDEWEVIRRENRRY RLRWFTFT*VFY*GHQNEWL*RIL*RKSKK*KL NSEATRKED****NNMGK**VANRENKP*RF**R SFLSDKR*ARCTPCRQSASLW*IHGCQLKISHS SPAGFARSRNSF*GAGESSRIKTFGSVSNWAN* GKQKEEQI*KYTSL*CYKSASWR*RWLYQCQLH* DTSWERRVRLHCLPRTTAYNCWRLLADDLGAKI HSDSHDDSRSRRRKNQMPALLAQHPRQNNNGQQ QTSTGSCENAAAEGLCGEGNDP*RYSDQRGAPYF SSEFHCLARP*YTFSTR*SAYFYLLHETHPQIR PNHYALQCWHWTFRDPDLHRCGSGINQSGS*F* HL*FGALHETTKTRNGSDRGSIYFLLSSHPLCPD TSSSRRRAKTAASASEVT*KEPLDAFPFLSLTS SRLLLSIQNKDHRAASSYNMHVLLYLRGVFFLK IKNIEMLYFYSYFNL**LFTKF*H*PNNADLRDD *RQHLMIADIVTRTW*VYF*CTNLVYSKNVFQY FNKVVIL*GILETSI*ALNDSNIGIEKSSKCLL YQFLMFTI*NFL*YIYILFHENGVISYLFVTASS VCNHYLTL*IKTHLKT*TSQNCVQ

Sequence PTPN13.bAug05

GAGTAGCTCCAGCGGCCACGCTGAGGCGAGGGTGACACACCATGCTCACGGCCCCTGGAGACCGTCGTGCTGGCGAGCCGTGCTCCGTAGCTCCCCGGTC CGCCTCGGCAGCGGTCAGAGTCGCCTACAGGAGTTGAGCCGCCCGCGCCAGAAGGTTTTGGCGAAGCTCTTGGAGAGGCGTCGAGCACAGTAGGGCGGCG GGGGTGCGTTGAGCGCTCGGGGGTCAGGCAGTCGGCCGGGATCGCCGCTGGGGAGCGTTTCCGAGGCGAGGAGGAGGAGGAGGAGATGCTGCTCCTCTTC TCCCCCTCCCCAGGCTCCTTCTACAGCTCCTTCAGCCCACGCCCGCAGCCGCTTGTGGGAGAAGTGGTGGTGGCTCTCGGCGCCCGCGGCGGCTGCCGGC GGCCCGCCCCGACGCCGCGTCCCTGCAGCCCTCGCCCGGCGCTCCAGTAGCAGGACCCGGTCTCGGGACCAGCCGGTAATATGCACGTGTCACTAGCTGA GGCCCTGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTGTATTAAATCAAAGTGCTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGC CTAGCTGATCCTGCTGCCCTTGGCTTCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTTACAGATGAAAATATTTCCAATC AGGATCTTCGAGCATTCACTGCACCAGAGGTTCTTCAAAATCAGTCACTAACTTCTCTCTCAGATGTTGAAAAGATCCACATTTATTCTCTTGGAATGAC ACTGTATTGGGGGGCTGATTATGAAGTGCCTCAGAGCCAACCTATTAAGCTTGGAGATCATCTCAACAGCATACTGCTTGGAATGTGTGAGGATGTTATT TACGCTCGAGTTTCTGTTCGGACTGTGCTGGATGCTTGCAGTGCCCACATTAGGAATAGCAATTGTGCACCCTCATTTTCCTACGTGAAACACTTGGTAA AACTGGTTCTGGGAAATCTTTCTGGGACAGATCAGCTTTCCTGTAACAGTGAACAAAAGCCTGATCGAAGCCAGGCTATTCGAGATCGATTGCGAGGAAA AGGATTACCAACAGGAAGAAGCTCTACTTCTGATGTACTAGACATACAAAAGCCTCCACTCTCTCATCAGACCTTTCTTAACAAAGGGCTTAGTAAATCT ATGGGATTTCTGTCCATCAAAGATACACAAGATGAGAATTATTTCAAGGACATTTTATCAGATAATTCTGGACGTGAAGATTCTGAAAATACATTCTCCC CTTACCAGTTCAAAACTAGTGGCCCAGAAAAAAAACCCATCCCTGGCATTGATGTGCTTTCTAAGAAGAAGATCTGGGCTTCATCCATGGACTTGCTTTG TACAGCTGACAGAGACTTCTCTTCAGGAGAGACTGCCACATATCGTCGTTGTCACCCTGAGGCAGTAACAGTGCGGACTTCAACTACTCCTAGAAAAAAG GAGGCAAGATACTCAGATGGAAGTATAGCCTTGGATATCTTTGGCCCTCAGAAAATGGATCCAATATATCACACTCGAGAATTGCCCACCTCCTCAGCAA TATCAAGTGCTTTGGACCGAATCCGAGAGAGACAAAAGAAACTTCAGGTTCTGAGGGAAGCCATGAATGTAGAAGAACCAGTTCGAAGATACAAAACTTA TCATGGTGATGTCTTTAGTACCTCCAGTGAAAGTCCATCTATTATTTCCTCTGAATCAGATTTCAGACAAGTGAGAAGAAGTGAAGCCTCAAAGAGGTTT GAATCCAGCAGTGGTCTCCCAGGGGTAGATGAAACCTTAAGTCAAGGCCAGTCACAGAGACCGAGCAGACAATATGAAACACCCTTTGAAGGCAACTTAA TTAATCAAGAGATCATGCTAAAACGGCAAGAGGAAGAACTGATGCAGCTACAAGCCAAAATGGCCCTTAGACAGTCTCGGTTGAGCCTATATCCAGGAGA CACAATCAAAGCGTCCATGCTTGACATCACCAGGGATCCGTTAAGAGAAATTGCCCTAGAAACAGCCATGACTCAAAGAAAACTGAGGAATTTCTTTGGC CCTGAGTTTGTGAAAATGACAATTGAACCATTTATATCTTTGGATTTGCCACGGTCTATTCTTACTAAGAAAGGGAAGAATGAGGATAACCGAAGGAAAG TAAACATAATGCTTCTGAACGGGCAAAGACTGGAACTGACCTGTGATACCAAAACTATATGTAAAGATGTGTTTGATATGGTTGTGGCACATATTGGCTT AGTAGAGCATCATTTGTTTGCTTTAGCTACCCTCAAAGATAATGAATATTTCTTTGTTGATCCTGACTTAAAATTAACCAAAGTGGCCCCAGAGGGATGG AAAGAAGAACCAAAGAAAAAGACCAAAGCCACTGTTAATTTTACTTTGTTTTTCAGAATTAAATTTTTTATGGATGATGTTAGTCTAATACAACATACTC TGACGTGTCATCAGTATTACCTTCAGCTTCGAAAAGATATTTTGGAGGAAAGGATGCACTGTGATGATGAGACTTCCTTATTGCTGGCATCCTTGGCTCT CCAGGCTGAGTATGGAGATTATCAACCAGAGGTTCATGGTGTGTCTTACTTTAGAATGGAGCACTATTTGCCCGCCAGAGTGATGGAGAAACTTGATTTA TCCTATATCAAAGAAGAGTTACCCAAATTGCATAATACCTATGTGGGAGCTTCTGAAAAAGAGACAGAGTTAGAATTTTTAAAGGTCTGCCAAAGACTGA CAGAATATGGAGTTCATTTTCACCGAGTGCACCCTGAGAAGAAGTCACAAACAGGAATATTGCTTGGAGTCTGTTCTAAAGGTGTCCTTGTGTTTGAAGT TCACAATGGAGTGCGCACATTGGTCCTTCGCTTTCCATGGAGGGAAACCAAGAAAATATCTTTTTCTAAAAAGAAAATCACATTGCAAAATACATCAGAT GGAATAAAACATGGCTTCCAGACAGACAACAGTAAGATATGCCAGTACCTGCTGCACCTCTGCTCTTACCAGCATAAGTTCCAGCTACAGATGAGAGCAA GACAGAGCAACCAAGATGCCCAAGATATTGAGAGAGCTTCGTTTAGGAGCCTGAATCTCCAAGCAGAGTCTGTTAGAGGATTTAATATGGGACGAGCAAT CAGCACTGGCAGTCTGGCCAGCAGCACCCTCAACAAACTTGCTGTTCGACCTTTATCAGTTCAAGCTGAGATTCTGAAGAGGCTATCCTGCTCAGAGCTG TCGCTTTACCAGCCATTGCAAAACAGTTCAAAAGAGAAGAATGACAAAGCTTCATGGGAGGAAAAGCCTAGAGAGATGAGTAAATCATACCATGATCTCA GTCAGGCCTCTCTCTATCCACATCGGAAAAATGTCATTGTTAACATGGAACCCCCACCACAAACCGTTGCAGAGTTGGTGGGAAAACCTTCTCACCAGAT GTCAAGATCTGATGCAGAATCTTTGGCAGGAGTGACAAAACTTAATAATTCAAAGTCTGTTGCGAGTTTAAATAGAAGTCCTGAAAGGAGGAAACATGAA TCAGACTCCTCATCCATTGAAGACCCTGGGCAAGCATATGTTCTAGGAATGACTATGCATAGTTCTGGAAACTCTTCATCCCAAGTACCCTTAAAAGAAA ATGATGTGCTACACAAAAGATGGAGCATAGTATCTTCACCAGAAAGGGAGATCACCTTAGTGAACCTGAAAAAAGATGCAAAGTATGGCTTGGGATTTCA AATTATTGGTGGGGAGAAGATGGGAAGACTGGACCTAGGCATATTTATCAGTTCAGTTGCCCCTGGAGGACCAGCTGACTTGGATGGATGCTTGAAGCCA GGAGACCGTTTGATATCTGTGAATAGTGTGAGTCTGGAGGGAGTCAGCCACCATGCTGCAATTGAAATTTTGCAAAATGCACCTGAAGATGTGACACTTG TTATCTCTCAGCCAAAAGAAAAGATATCCAAAGTGCCTTCTACTCCTGTGCATCTCACCAATGAGATGAAAAACTACATGAAGAAATCTTCCTACATGCA AGACAGTGCTATAGATTCTTCTTCCAAGGATCACCACTGGTCACGTGGTACCCTGAGGCACATCTCGGAGAACTCCTTTGGGCCATCTGGGGGCCTGCGG GAAGGAAGCCTGAGTTCTCAAGATTCCAGGACTGAGAGTGCCAGCTTGTCTCAAAGCCAGGTCAATGGTTTCTTTGCCAGCCATTTAGGTGACCAAACCT GGCAGGAATCACAGCATGGCAGCCCTTCCCCATCTGTAATATCCAAAGCCACCGAGAAAGAGACTTTCACTGATAGTAACCAAAGCAAAACTAAAAAGCC AGGCATTTCTGATGTAACTGATTACTCAGACCGTGGAGATTCAGACATGGATGAAGCCACTTACTCCAGCAGTCAGGATCATCAAACACCAAAACAGGAA TCTTCCTCTTCAGTGAATACATCCAACAAGATGAATTTTAAAACTTTTTCTTCATCACCTCCTAAGCCTGGAGATATCTTTGAGGTTGAACTGGCTAAAA ATGATAACAGCTTGGGGATAAGTGTCACGGGAGGTGTGAATACGAGTGTCAGACATGGTGGCATTTATGTGAAAGCTGTTATTCCCCAGGGAGCAGCAGA GTCTGATGGTAGAATTCACAAAGGTGATCGCGTCCTAGCTGTCAATGGAGTTAGTCTAGAAGGAGCCACCCATAAGCAAGCTGTGGAAACACTGAGAAAT ACAGGACAGGTGGTTCATCTGTTATTAGAAAAGGGACAATCTCCAACATCTAAAGAACATGTCCCGGTAACCCCACAGTGTACCCTTTCAGATCAGAATG CCCAAGGTCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAGGTCAAAGACTACAGCTTTGTCACTGAAGAAAATACATTTGAGGTAAAATTATTTAAAAA TAGCTCAGGTCTAGGATTCAGTTTTTCTCGAGAAGATAATCTTATACCGGAGCAAATTAATGCCAGCATAGTAAGGGTTAAAAAGCTCTTTCCTGGACAG CCAGCAGCAGAAAGTGGAAAAATTGATGTAGGAGATGTTATCTTGAAAGTGAATGGAGCCTCTTTGAAAGGACTATCTCAGCAGGAAGTCATATCTGCTC TCAGGGGAACTGCTCCAGAAGTATTCTTGCTTCTCTGCAGACCTCCACCTGGTGTGCTACCGGAAATTGATACTGCGCTTTTGACCCCACTTCAGTCTCC AGCACAAGTACTTCCAAACAGCAGTAAAGACTCTTCTCAGCCATCATGTGTGGAGCAAAGCACCAGCTCAGATGAAAATGAAATGTCAGACAAAAGCAAA AAACAGTGCAAGTCCCCATCCAGAAGAGACAGTTACAGTGACAGCAGTGGGAGTGGAGAAGATGACTTAGTGACAGCTCCAGCAAACATATCAAATTCGA CCTGGAGTTCAGCTTTGCATCAGACTCTAAGCAACATGGTATCACAGGCACAGAGTCATCATGAAGCACCCAAGAGTCAAGAAGATACCATTTGTACCAT GTTTTACTATCCTCAGAAAATTCCCAATAAACCAGAGTTTGAGGACAGTAATCCTTCCCCTCTACCACCGGATATGGCTCCTGGGCAGAGTTATCAACCC CAATCAGAATCTGCTTCCTCTAGTTCGATGGATAAGTATCATATACATCACATTTCTGAACCAACTAGACAAGAAAACTGGACACCTTTGAAAAATGACT TGGAAAATCACCTTGAAGACTTTGAACTGGAAGTAGAACTCCTCATTACCCTAATTAAATCAGAAAAAGGAAGCCTGGGTTTTACAGTAACCAAAGGCAA TCAGAGAATTGGTTGTTATGTTCATGATGTCATACAGGATCCAGCCAAAAGTGATGGAAGGCTAAAACCTGGGGACCGGCTCATAAAGGTTAATGATACA GATGTTACTAATATGACTCATACAGATGCAGTTAATCTGCTCCGGGCTGCATCCAAAACAGTCAGATTAGTTATTGGACGAGTTCTAGAATTACCCAGAA TACCAATGTTGCCTCATTTGCTACCGGACATAACACTAACGTGCAACAAAGAGGAGTTGGGTTTTTCCTTATGTGGAGGTCATGACAGCCTTTATCAAGT GGTATATATTAGTGATATTAATCCAAGGTCCGTCGCAGCCATTGAGGGTAATCTCCAGCTATTAGATGTCATCCATTATGTGAACGGAGTCAGCACACAA GGAATGACCTTGGAGGAAGTTAACAGAGCATTAGACATGTCACTTCCTTCATTGGTATTGAAAGCAACAAGAAATGATCTTCCAGTGGTCCCCAGCTCAA AGAGGTCTGCTGTTTCAGCTCCAAAGTCAACCAAAGGCAATGGTTCCTACAGTGTGGGGTCTTGCAGCCAGCCTGCCCTCACTCCTAATGATTCATTCTC CACGGTTGCTGGGGAAGAAATAAATGAAATATCGTACCCCAAAGGAAAATGTTCTACTTATCAGATAAAGGGATCACCAAACTTGACTCTGCCCAAAGAA TCTTATATACAAGAAGATGACATTTATGATGATTCCCAAGAAGCTGAAGTTATCCAGTCTCTGCTGGATGTTGTGGATGAGGAAGCCCAGAATCTTTTAA ACGAAAATAATGCAGCAGGATACTCCTGTGGTCCAGGTACATTAAAGATGAATGGGAAGTTATCAGAAGAGAGAACAGAAGATACAGACTGCGATGGTTC ACCTTTACCTGAGTATTTTACTGAGGCCACCAAAATGAATGGCTGTGAAGAATATTGTGAAGAAAAAGTAAAAAGTGAAAGCTTAATTCAGAAGCCACAA GAAAAGAAGACTGATGATGATGAAATAACATGGGGAAATGATGAGTTGCCAATAGAGAGAACAAACCATGAAGATTCTGATAAAGATCATTCCTTTCTGA CAAACGATGAGCTCGCTGTACTCCCTGTCGTCAAAGTGCTTCCCTCTGGTAAATACACGGGTGCCAACTTAAAATCAGTCATTCGAGTCCTGCGGGGTTT GCTAGATCAAGGAATTCCTTCTAAGGAGCTGGAGAATCTTCAAGAATTAAAACCTTTGGATCAGTGTCTAATTGGGCAAACTAAGGAAAACAGAAGGAAG AACAGATATAAAAATATACTTCCCTATGATGCTACAAGAGTGCCTCTTGGAGATGAAGGTGGCTATATCAATGCCAGCTTCATTAAGATACCAGTTGGGA AAGAAGAGTTCGTTTACATTGCCTGCCAAGGACCACTGCCTACAACTGTTGGAGACTTCTGGCAGATGATTTGGGAGCAAAAATCCACAGTGATAGCCAT GATGACTCAAGAAGTAGAAGGAGAAAAAATCAAATGCCAGCGCTATTGGCCCAACATCCTAGGCAAAACAACAATGGTCAGCAACAGACTTCGACTGGCT CTTGTGAGAATGCAGCAGCTGAAGGGCTTTGTGGTGAGGGCAATGACCCTTGAAGATATTCAGACCAGAGAGGTGCGCCATATTTCTCATCTGAATTTCA CTGCCTGGCCAGACCATGATACACCTTCTCAACCAGATGATCTGCTTACTTTTATCTCCTACATGAGACACATCCACAGATCAGGCCCAATCATTACGCA CTGCAGTGCTGGCATTGGACGTTCAGGGACCCTGATTTGCATAGATGTGGTTCTGGGATTAATCAGTCAGGATCTTGATTTTGACATCTCTGATTTGGTG CGCTGCATGAGACTACAAAGACACGGAATGGTTCAGACAGAGGATCAATATATTTTCTGCTATCAAGTCATCCTTTATGTCCTGACACGTCTTCAAGCAG AAGAAGAGCAAAAACAGCAGCCTCAGCTTCTGAAGTGACATGAAAAGAGCCTCTGGATGCATTTCCATTTCTCTCCTTAACCTCCAGCAGACTCCTGCTC TCTATCCAAAATAAAGATCACAGAGCAGCAAGTTCATACAACATGCATGTTCTCCTCTATCTTAGAGGGGTATTCTTCTTGAAAATAAAAAATATTGAAA TGCTGTATTTTTACAGCTACTTTAACCTATGATAATTATTTACAAAATTTTAACACTAACCAAACAATGCAGATCTTAGGGATGATTAAAGGCAGCATTT GATGATAGCAGACATTGTTACAAGGACATGGTGAGTCTATTTTTAATGCACCAATCTTGTTTATAGCAAAAATGTTTTCCAATATTTTAATAAAGTAGTT ATTTTATAGGGGATACTTGAAACCAGTATTTAAGCTTTAAATGACAGTAATATTGGCATAGAAAAAAGTAGCAAATGTTTACTGTATCAATTTCTAATGT TTACTATATAGAATTTCCTGTAATATATTTATATACTTTTTCATGAAAATGGAGTTATCAGTTATCTGTTTGTTACTGCATCATCTGTTTGTAATCATTA TCTCACTTTGTAAATAAAAACACACCTTAAAACATGAACAAGCCAAAACTGTGTGCAGAC

PTPN13.F7 (forward primer)
PTPN13.R7 (reverse primer)
Single exon skipping

Frame 0

E*LQRPR*GEGDTPCSRPLETVVLASRAP*LPG PPRQRSESPTGVEPPAPEGFGEALGEASSTVGRR GCVERSGVRQSAGIAAGERFRGEEEEEEMLLLF SPSPGSFYSSFSPRPQPLVGEVVVALGARGGCR RPAPTPRPCSPRPALQ*QDPVSGPAGNMHVSLAE ALEVRGGPLQEEEIWAVLNQSAESLQELFRKVS LADPAALGFIISPWSLLLLPSGSVSFTDENISN QDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMT LYWGADYEVPQSQPIKLGDHLNSILLGMCEDVI YARVSVRTVLDACSAHIRNSNCAPSFSYVKHLV KLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGK GLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS MGFLSIKDTQDENYFKDILSDNSGREDSENTFS PYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLC TADRDFSSGETATYRRCHPEAVTVRTSTTPRKK EARYSDGSIALDIFGPQKMDPIYHTRELPTSSA ISSALDRIRERQKKLQVLREAMNVEEPVRRYKTY HGDVFSTSSESPSIISSESDFRQVRRSEASKRF ESSSGLPGVDETLSQGQSQRPSRQYETPFEGNL INQEIMLKRQEEELMQLQAKMALRQSRLSLYPGD TIKASMLDITRDPLREIALETAMTQRKLRNFFG PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRK VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGL VEHHLFALATLKDNEYFFVDPDLKLTKVAPEGW KEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHT LTCHQYYLQLRKDILEERMHCDDETSLLLASLAL QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL SYIKEELPKLHNTYVGASEKETELEFLKVCQRL TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEV HNGVRTLVLRFPWRETKKISFSKKKITLQNTSD GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRA RQSNQDAQDIERASFRSLNLQAESVRGFNMGRAI STGSLASSTLNKLAVRPLSVQAEILKRLSCSEL SLYQPLQNSSKEKNDKASWEEKPREMSKSYHDL SQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQM SRSDAESLAGVTKLNNSKSVASLNRSPERRKHE SDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKE NDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQ IIGGEKMGRLDLGIFISSVAPGGPADLDGCLKP GDRLISVNSVSLEGVSHHAAIEILQNAPEDVTL VISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLR EGSLSSQDSRTESASLSQSQVNGFFASHLGDQT WQESQHGSPSPSVISKATEKETFTDSNQSKTKKP GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQE SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK NDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAE SDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN TGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKN SSGLGFSFSREDNLIPEQINASIVRVKKLFPGQ PAAESGKIDVGDVILKVNGASLKGLSQQEVISA LRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSP AQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSK KQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM FYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQP QSESASSSSMDKYHIHHISEPTRQENWTPLKND LENHLEDFELEVELLITLIKSEKGSLGFTVTKGN QRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDT DVTNMTHTDAVNLLRAASKTVRLVIGRVLELPR IPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQV VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSS KRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFS TVAGEEINEISYPKGKCSTYQIKGSPNLTLPKE SYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLL NENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGS PLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQ EKKTDDDEITWGNDELPIERTNHEDSDKDHSFL TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGL LDQGIPSKELENLQELKPLDQCLIGQTKENRRK NRYKNILPYDATRVPLGDEGGYINASFIKIPVG KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAM MTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLA LVRMQQLKGFVVRAMTLEDIQTREVRHISHLNF TAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITH CSAGIGRSGTLICIDVVLGLISQDLDFDISDLV RCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQA EEEQKQQPQLLK*HEKSLWMHFHFSP*PPADSCS LSKIKITEQQVHTTCMFSSILEGYSS*K*KILK CCIFTATLTYDNYLQNFNTNQTMQILGMIKGSI ***QTLLQGHGESIFNAPILFIAKMFSNILIK*L FYRGYLKPVFKL*MTVILA*KKVANVYCINF*C LLYRISCNIFIYFFMKMELSVICLLLHHLFVII ISLCK*KHTLKHEQAKTVCR

Frame 1

SSSSGHAEARVTHHAHGPWRPSCWRAVLRSSPV RLGSGQSRLQELSRPRQKVLAKLLERRRAQ*GG GGALSARGSGSRPGSPLGSVSEARRRRRRCCSSS PPPQAPSTAPSAHARSRLWEKWWWLSAPAAAAG GPPRRRVPAALARRSSSRTRSRDQPVICTCH*L RPWRFGVDHFRRKKYGLY*IKVLKVSKNYSEK*A *LILLPLASSFLHGLCCCCHLVVCHLQMKIFPI RIFEHSLHQRFFKISH*LLSQMLKRSTFILLE* HCIGGLIMKCLRANLLSLEIISTAYCLECVRMLF TLEFLFGLCWMLAVPTLGIAIVHPHFPT*NTW* NWFWEIFLGQISFPVTVNKSLIEARLFEIDCEE KDYQQEEALLLMY*TYKSLHSLIRPFLTKGLVNL WDFCPSKIHKMRIISRTFYQIILDVKILKIHSP LTSSKLVAQKKNPSLALMCFLRRRSGLHPWTCF VQLTETSLQERLPHIVVVTLRQ*QCGLQLLLEKR RQDTQMEV*PWISLALRKWIQYITLENCPPPQQ YQVLWTESERDKRNFRF*GKP*M*KNQFEDTKL IMVMSLVPPVKVHLLFPLNQISDK*EEVKPQRGL NPAVVSQG*MKP*VKASHRDRADNMKHPLKAT* LIKRSC*NGKRKN*CSYKPKWPLDSLG*AYIQE TQSKRPCLTSPGIR*EKLP*KQP*LKEN*GISLA LSL*K*QLNHLYLWICHGLFLLRKGRMRITEGK *T*CF*TGKDWN*PVIPKLYVKMCLIWLWHILA **SIICLL*LPSKIMNISLLILT*N*PKWPQRDG KKNQRKRPKPLLILLCFSELNFLWMMLV*YNIL *RVISITFSFEKIFWRKGCTVMMRLPYCWHPWL SRLSMEIINQRFMVCLTLEWSTICPPE*WRNLIY PISKKSYPNCIIPMWELLKKRQS*NF*RSAKD* QNMEFIFTECTLRRSHKQEYCLESVLKVSLCLK FTMECAHWSFAFHGGKPRKYLFLKRKSHCKIHQM E*NMASRQTTVRYASTCCTSALTSISSSYR*EQ DRATKMPKILRELRLGA*ISKQSLLEDLIWDEQ SALAVWPAAPSTNLLFDLYQFKLRF*RGYPAQSC RFTSHCKTVQKRRMTKLHGRKSLER*VNHTMIS VRPLSIHIGKMSLLTWNPHHKPLQSWWENLLTR CQDLMQNLWQE*QNLIIQSLLRV*IEVLKGGNMN QTPHPLKTLGKHMF*E*LCIVLETLHPKYP*KK MMCYTKDGA*YLHQKGRSP**T*KKMQSMAWDF KLLVGRRWEDWT*AYLSVQLPLEDQLTWMDA*SQ ETV*YL*IV*VWRESATMLQLKFCKMHLKM*HL LSLSQKKRYPKCLLLLCISPMR*KTT*RNLPTC KTVL*ILLPRITTGHVVP*GTSRRTPLGHLGACG KEA*VLKIPGLRVPACLKARSMVSLPAI*VTKP GRNHSMAALPHL*YPKPPRKRLSLIVTKAKLKS QAFLM*LITQTVEIQTWMKPLTPAVRIIKHQNRN LPLQ*IHPTR*ILKLFLHHLLSLEISLRLNWLK MITAWG*VSREV*IRVSDMVAFM*KLLFPREQQ SLMVEFTKVIAS*LSMELV*KEPPISKLWKH*EI QDRWFICY*KRDNLQHLKNMSR*PHSVPFQIRM PKVKAQKK*RKQLRSKTTALSLKKIHLR*NYLK IAQV*DSVFLEKIILYRSKLMPA**GLKSSFLDS QQQKVEKLM*EMLS*K*MEPL*KDYLSRKSYLL SGELLQKYSCFSADLHLVCYRKLILRF*PHFSL QHKYFQTAVKTLLSHHVWSKAPAQMKMKCQTKAK NSASPHPEETVTVTAVGVEKMT**QLQQTYQIR PGVQLCIRL*ATWYHRHRVIMKHPRVKKIPFVP CFTILRKFPINQSLRTVILPLYHRIWLLGRVINP NQNLLPLVRWISIIYITFLNQLDKKTGHL*KMT WKITLKTLNWK*NSSLP*LNQKKEAWVLQ*PKA IRELVVMFMMSYRIQPKVMEG*NLGTGS*RLMIQ MLLI*LIQMQLICSGLHPKQSD*LLDEF*NYPE YQCCLICYRT*H*RATKRSWVFPYVEVMTAFIK WYILVILIQGPSQPLRVISSY*MSSIM*TESAHK E*PWRKLTEH*TCHFLHWY*KQQEMIFQWSPAQ RGLLFQLQSQPKAMVPTVWGLAASLPSLLMIHS PRLLGKK*MKYRTPKENVLLIR*RDHQT*LCPKN LIYKKMTFMMIPKKLKLSSLCWMLWMRKPRIF* TKIMQQDTPVVQVH*R*MGSYQKREQKIQTAMV HLYLSILLRPPK*MAVKNIVKKK*KVKA*FRSHK KRRLMMMK*HGEMMSCQ*REQTMKILIKIIPF* QTMSSLYSLSSKCFPLVNTRVPT*NQSFESCGV C*IKEFLLRSWRIFKN*NLWISV*LGKLRKTEGR TDIKIYFPMMLQECLLEMKVAISMPASLRYQLG KKSSFTLPAKDHCLQLLETSGR*FGSKNPQ**P **LKK*KEKKSNASAIGPTS*AKQQWSATDFDWL L*ECSS*RALW*GQ*PLKIFRPERCAIFLI*IS LPGQTMIHLLNQMICLLLSPT*DTSTDQAQSLR TAVLALDVQGP*FA*MWFWD*SVRILILTSLIWC AA*DYKDTEWFRQRINIFSAIKSSFMS*HVFKQ KKSKNSSLSF*SDMKRASGCISISLLNLQQTPA LYPK*RSQSSKFIQHACSPLS*RGILLENKKY*N AVFLQLL*PMIIIYKILTLTKQCRS*G*LKAAF DDSRHCYKDMVSLFLMHQSCL*QKCFPIF**SS YFIGDT*NQYLSFK*Q*YWHRKK*QMFTVSISNV YYIEFPVIYLYTFS*KWSYQLSVCYCIICL*SL SHFVNKNTP*NMNKPKLCAD

Frame 2

VAPAATLRRG*HTMLTAPGDRRAGEPCSVAPRS ASAAVRVAYRS*AARARRFWRSSWRGVEHSRAA GVR*ALGGQAVGRDRRWGAFPRRGGGGGDAAPL LPLPRLLLQLLQPTPAAACGRSGGGSRRPRRLPA ARPDAASLQPSPGAPVAGPGLGTSR*YARVTS* GPGGSGWTTSGGRNMGCIKSKC*KSPRIIQKSK PS*SCCPWLHHFSMVSAVAAIW*CVIYR*KYFQS GSSSIHCTRGSSKSVTNFSLRC*KDPHLFSWND TVLGG*L*SASEPTY*AWRSSQQHTAWNV*GCY LRSSFCSDCAGCLQCPH*E*QLCTLIFLRETLGK TGSGKSFWDRSAFL*Q*TKA*SKPGYSRSIARK RITNRKKLYF*CTRHTKASTLSSDLS*QRA**I YGISVHQRYTR*ELFQGHFIR*FWT*RF*KYILP LPVQN*WPRKKTHPWH*CAF*EEDLGFIHGLAL YS*QRLLFRRDCHISSLSP*GSNSADFNYS*KK GGKILRWKYSLGYLWPSENGSNISHSRIAHLLSN IKCFGPNPRETKETSGSEGSHECRRTSSKIQNL SW*CL*YLQ*KSIYYFL*IRFQTSEKK*SLKEV *IQQWSPRGR*NLKSRPVTETEQTI*NTL*RQLN *SRDHAKTARGRTDAATSQNGP*TVSVEPISRR HNQSVHA*HHQGSVKRNCPRNSHDSKKTEEFLW P*VCENDN*TIYIFGFATVYSY*EREE*G*PKES KHNASERAKTGTDL*YQNYM*RCV*YGCGTYWL SRASFVCFSYPQR**IFLC*S*LKINQSGPRGM ERRTKEKDQSHC*FYFVFQN*IFYG*C*SNTTYS DVSSVLPSASKRYFGGKDAL***DFLIAGILGS PG*VWRLSTRGSWCVLL*NGALFARQSDGET*F ILYQRRVTQIA*YLCGSF*KRDRVRIFKGLPKTD RIWSSFSPSAP*EEVTNRNIAWSLF*RCPCV*S SQWSAHIGPSLSMEGNQENIFF*KENHIAKYIR WNKTWLPDRQQ*DMPVPAAPLLLPA*VPATDESK TEQPRCPRY*ESFV*EPESPSRVC*RI*YGTSN QHWQSGQQHPQQTCCSTFISSS*DSEEAILLRA VALPAIAKQFKREE*QSFMGGKA*RDE*IIP*SQ SGLSLSTSEKCHC*HGTPTTNRCRVGGKTFSPD VKI*CRIFGRSDKT**FKVCCEFK*KS*KEET* IRLLIH*RPWASICSRNDYA*FWKLFIPSTLKRK *CATQKMEHSIFTRKGDHLSEPEKRCKVWLGIS NYWWGEDGKTGPRHIYQFSCPWRTS*LGWMLEA RRPFDICE*CESGGSQPPCCN*NFAKCT*RCDTC YLSAKRKDIQSAFYSCASHQ*DEKLHEEIFLHA RQCYRFFFQGSPLVTWYPEAHLGELLWAIWGPA GRKPEFSRFQD*ECQLVSKPGQWFLCQPFR*PNL AGITAWQPFPICNIQSHRERDFH***PKQN*KA RHF*CN*LLRPWRFRHG*SHLLQQSGSSNTKTG IFLFSEYIQQDEF*NFFFITS*AWRYL*G*TG*K **QLGDKCHGRCEYECQTWWHLCESCYSPGSSR V*W*NSQR*SRPSCQWS*SRRSHP*ASCGNTEK YRTGGSSVIRKGTISNI*RTCPGNPTVYPFRSEC PRSRPRKSEENNSGQRLQLCH*RKYI*GKII*K *LRSRIQFFSRR*SYTGAN*CQHSKG*KALSWT ASSRKWKN*CRRCYLESEWSLFERTISAGSHICS QGNCSRSILASLQTSTWCATGN*YCAFDPTSVS STSTSKQQ*RLFSAIMCGAKHQLR*K*NVRQKQ KTVQVPIQKRQLQ*QQWEWRR*LSDSSSKHIKFD LEFSFASDSKQHGITGTESS*STQESRRYHLYH VLLSSENSQ*TRV*GQ*SFPSTTGYGSWAELST PIRICFL*FDG*VSYTSHF*TN*TRKLDTFEK*L GKSP*RL*TGSRTPHYPN*IRKRKPGFYSNQRQ SENWLLCS*CHTGSSQK*WKAKTWGPAHKG**Y RCY*YDSYRCS*SAPGCIQNSQISYWTSSRITQN TNVASFATGHNTNVQQRGVGFFLMWRS*QPLSS GIY**Y*SKVRRSH*G*SPAIRCHPLCERSQHT RNDLGGS*QSIRHVTSFIGIESNKK*SSSGPQLK EVCCFSSKVNQRQWFLQCGVLQPACPHS**FIL HGCWGRNK*NIVPQRKMFYLSDKGITKLDSAQR ILYTRR*HL**FPRS*SYPVSAGCCG*GSPESFK RK*CSRILLWSRYIKDEWEVIRRENRRYRLRWF TFT*VFY*GHQNEWL*RIL*RKSKK*KLNSEAT RKED****NNMGK**VANRENKP*RF**RSFLSD KR*ARCTPCRQSASLW*IHGCQLKISHSSPAGF ARSRNSF*GAGESSRIKTFGSVSNWAN*GKQKE EQI*KYTSL*CYKSASWR*RWLYQCQLH*DTSWE RRVRLHCLPRTTAYNCWRLLADDLGAKIHSDSH DDSRSRRRKNQMPALLAQHPRQNNNGQQQTSTG SCENAAAEGLCGEGNDP*RYSDQRGAPYFSSEFH CLARP*YTFSTR*SAYFYLLHETHPQIRPNHYA LQCWHWTFRDPDLHRCGSGINQSGS*F*HL*FG ALHETTKTRNGSDRGSIYFLLSSHPLCPDTSSSR RRAKTAASASEVT*KEPLDAFPFLSLTSSRLLL SIQNKDHRAASSYNMHVLLYLRGVFFLKIKNIE MLYFYSYFNL**LFTKF*H*PNNADLRDD*RQHL MIADIVTRTW*VYF*CTNLVYSKNVFQYFNKVV IL*GILETSI*ALNDSNIGIEKSSKCLLYQFLM FTI*NFL*YIYILFHENGVISYLFVTASSVCNHY LTL*IKTHLKT*TSQNCVQ