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Sequences

Sequence NUP98.bAug05

CCCAGCAGCGCCGGCGGACCGGGGCAAGGAAAGGGTCGAATAGTTACCATGCCATTCTGGGGCCGTCCCTCTGATTGGCCCGAGCTCCCTCAGCCCGAGT CGCGGCGCTCCAAGGAAGGGGGCGGAGTCTCTATGTTGCGTCACCACCCTTCCCGACACCCCGCCGGTGCTTCCCAATCTAGCCATTCACAAGCCCACTT CGAGAGGCCCTGTGTGACGTCACGACACGCTCCCGCCAACCGCGGCGGCGAGGGGCGGGACTCCACGGCCCTCTCACCGCTCCTACCCTGTGCCTCCCCG AACTCCTTCTGCCCCTCCTCTTCCCTCTCGCCCCTTCCCCCTTCAGTTCGGTTTCAAAAGACGCGTTGCCCAATGAATAACAGGGTCGACCCAGAGTGGC GGCCGCGTCCACCAATTCGCGGACGGCGAGGGCGGAGCGTCCGCAACGAGCCTCTGACGCCGGGCGGCGTGTGACGCAGTCGGGCCCTCTGCGCGCTGCG CCCGAAGCGGCGGTCGGTGGCAGGGGTGGTAGCGGCGGCGGCGACGGTTTCGTGGGGGCCGCGCGCTGCTCTGTGAGCGGCGGGTGGCAGCAGGGGACTC CTGACACTTCCCCTTCCCCACCGAACCGCGCTTTCTGAAACAAAGACTCATTTTGAAGATGTTTAACAAATCATTTGGAACACCCTTTGGGGGTGGCACA GGTGGCTTTGGCACAACTTCAACATTTGGACAGAATACTGGCTTTGGCACTACTAGTGGAGGGGCATTTGGAACATCTGCATTTGGTTCTAGCAACAATA CTGGAGGCCTCTTTGGAAATTCACAGACTAAACCAGGAGGATTGTTTGGAACCAGTTCATTTAGCCAGCCAGCTACCTCCACAAGCACTGGCTTTGGGTT TGGTACGTCAACAGGAACAGCAAATACCTTGTTTGGAACTGCAAGCACAGGGACCAGTCTCTTCTCATCCCAAAACAATGCCTTTGCACAAAATAAACCA ACTGGCTTTGGCAATTTTGGAACCAGTACTAGCAGTGGAGGACTCTTTGGAACCACAAATACCACCTCTAATCCTTTTGGCAGCACATCTGGCTCCCTCT TTGGGCCAAGTAGTTTTACAGCTGCTCCTACTGGGACTACTATTAAATTTAACCCTCCAACTGGTACAGATACTATGGTCAAAGCTGGAGTTAGCACTAA CATAAGTACCAAGCACCAGTGTATTACTGCTATGAAAGAATATGAAAGCAAGTCACTAGAGGAACTTCGTTTAGAGGATTATCAGGCTAACAGGAAGGGC CCACAGAACCAGGTGGGAGCAGGTACCACAACTGGCTTGTTTGGGTCTTCTCCAGCCACTTCCAGCGCAACAGGACTCTTCAGCTCCTCCACCACTAATT CAGGCTTTGCATATGGTCAGAACAAAACTGCCTTTGGAACTAGTACAACTGGATTTGGAACAAATCCAGGTGGTCTCTTTGGCCAACAGAATCAGCAGAC TACCAGCCTCTTCAGCAAACCATTTGGCCAGGCTACAACCACCCAGAACACTGGCTTTTCCTTTGGTAATACCAGCACCATAGGACAGCCAAGCACCAAC ACCATGGGATTATTTGGAGTAACCCAAGCCTCACAGCCTGGAGGTCTTTTTGGGACAGCTACAAACACCAGCACTGGGACAGCATTTGGAACAGGAACAG GTCTCTTTGGGCAGACCAATACTGGATTTGGTGCTGTTGGTTCGACCCTGTTTGGCAATAACAAGCTTACTACATTTGGAAGCAGCACAACCAGTGCACC TTCATTTGGTACAACCAGTGGCGGGCTCTTTGGTTTTGGCACAAATACCAGTGGGAATAGTATTTTTGGAAGTAAACCAGCACCTGGGACTCTTGGAACT GGGCTTGGTGCAGGATTTGGAACAGCTCTTGGTGCTGGACAGGCATCTTTGTTTGGGAACAACCAACCTAAGATTGGAGGGCCTCTTGGTACAGGAGCCT TTGGGGCCCCTGGATTTAATACTACGACAGCCACTTTGGGCTTTGGAGCCCCCCAGGCCCCAGTAGCTTTGACAGATCCAAATGCTTCTGCTGCCCAGCA GGCTGTTCTCCAGCAGCACATCAATAGTCTAACATACTCACCTTTTGGAGACTCTCCTCTCTTCCGGAATCCGATGTCAGACCCTAAGAAGAAGGAAGAG AGATTGAAACCAACAAATCCAGCAGCCCAGAAGGCTCTTACTACACCTACTCATTATAAACTGACACCCCGCCCTGCCACTAGAGTCCGGCCAAAGGCTT TACAAACAACAGGCACAGCCAAGTCACATCTCTTTGATGGGCTGGATGACGATGAACCATCCCTAGCCAATGGAGCATTCATGCCCAAGAAGAGCATTAA GAAGTTGGTTTTGAAGAACCTTAATAATAGCAATCTCTTTTCTCCTGTTAATCGTGATTCAGAAAATCTAGCTTCACCATCTGAATATCCAGAAAATGGA GAGAGATTTAGTTTCCTAAGCAAACCTGTTGATGAGAATCACCAGCAGGATGGAGATGAAGATTCCCTTGTTTCACATTTTTATACTAACCCTATTGCCA AACCTATTCCTCAAACCCCAGAAAGTGCTGGAAATAAACACAGCAACAGCAACAGTGTGGATGATACCATTGTTGCATTAAACATGCGTGCTGCTTTGCG AAATGGGCTGGAAGGAAGCAGTGAAGAAACGTCTTTTCATGATGAGTCACTTCAGGATGACCGAGAAGAAATAGAAAATAATTCTTACCATATGCACCCA GCAGGTATTATTCTCACTAAGGTTGGTTACTATACTATTCCATCTATGGATGACCTTGCTAAAATTACCAATGAAAAAGGAGAGTGCATTGTCTCTGATT TCACTATTGGTCGGAAAGGTTATGGTTCAATCTATTTTGAAGGAGATGTGAATTTGACAAATCTAAATTTGGATGATATTGTGCATATCCGGAGGAAAGA AGTAGTTGTCTACTTAGATGATAACCAAAAACCACCTGTGGGTGAAGGGCTAAATAGGAAGGCTGAAGTTACATTGGATGGAGTTTGGCCAACAGATAAA ACATCTCGTTGTTTAATAAAGAGCCCAGATCGCCTTGCTGATATCAACTATGAAGGAAGATTGGAAGCAGTTTCAAGGAAACAGGGAGCTCAATTCAAAG AATACCGGCCTGAAACTGGTTCTTGGGTGTTTAAGGTCTCCCATTTTTCTAAGTATGGCCTTCAGGATTCTGATGAAGAGGAGGAGGAGCATCCGTCTAA AACTAGTACAAAGAAGTTGAAGACTGCTCCTTTGCCTCCTGCAAGCCAGACTACGCCCTTGCAGATGGCTCTTAATGGCAAACCTGCACCTCCACCTCAG AGCCAGAGCCCAGAGGTGGAGCAGTTAGGGAGGGTTGTGGAACTGGACAGTGACATGGTAGATATCACCCAGGAGCCAGTTTTGGATACCATGTTAGAAG AGAGCATGCCTGAGGATCAGGAACCTGTGTCTGCCTCAACACATATTGCATCTTCACTGGGAATTAATCCACATGTCTTACAGATCATGAAAGCATCATT GCTTACTGATGAAGAAGATGTAGATATGGCACTGGATCAACGCTTCAGTCGCCTGCCTTCCAAAGCAGATACTTCTCAAGAAATCTGTTCTCCCAGACTC CCCATTTCAGCATCCCACTCGTCGAAAACTCGTTCACTAGTTGGTGGGTTACTACAATCAAAATTTACAAGTGGAGCTTTTCTTTCACCAAGTGTCTCTG TGCAAGAATGTCGTACTCCCAGAGCAGCATCTTTAATGAATATCCCATCCACATCCTCTTGGTCTGTCCCTCCACCCCTGACTTCTGTGTTCACAATGCC CAGCCCAGCCCCTGAGGTTCCGTTGAAAACAGTGGGTACACGTAGGCAACTAGGCCTAGTCCCTCGTGAAAAGTCTGTCACCTATGGCAAGGGAAAACTC TTGATGGACATGGCCCTATTCATGGGACGCTCATTTCGTGTTGGTTGGGGCCCCAACTGGACTCTTGCTAATAGTGGAGAACAGCTGAATGGCTCTCATG AACTAGAAAATCATCAGATTGCCGATTCCATGGAGTTTGGATTCCTGCCCAATCCAGTAGCTGTTAAACCCCTAACTGAGTCCCCATTCAAAGTTCACTT AGAAAAACTCAGTTTGAGACAAAGAAAGCCAGATGAAGACATGAAATTATATCAGACACCTCTGGAGCTCAAATTAAAACACAGCACTGTCCATGTGGAT GAACTGTGTCCTCTCATTGTCCCCAATCTGGGAGTTGCTGTCATTCATGACTATGCAGATTGGGTTAAAGAAGCATCAGGAGACTTACCAGAAGCACAAA TTGTGAAGCACTGGAGCCTGACATGGACACTATGTGAAGCCCTATGGGGCCACCTGAAGGAGCTTGACAGCCAGCTAAATGAACCCCGTGAATACATTCA AATTCTGGAGCGAAGAAGAGCTTTCTCCCGCTGGCTATCCTGTACTGCCACACCTCAGATTGAAGAGGAAGTCTCCTTAACCCAAAAAAACAGCCCTGTG GAGGCTGTATTCAGCTACCTCACAGGCAAAAGGATCAGTGAGGCCTGCTCTCTGGCCCAGCAGTCAGGGGATCATCGTCTTGCTCTTCTTTTATCTCAGT TTGTGGGTAGCCAGTCAGTCCGGGAGCTGCTCACCATGCAGTTGGTGGACTGGCATCAGCTCCAAGCAGACTCCTTCATCCAGGATGAGAGACTGCGCAT CTTTGCTCTGTTGGCTGGAAAACCGGTGTGGCAGCTCTCAGAAAAGAAGCAAATAAACGTGTGCTCCCAGTTGGATTGGAAACGCTCCCTGGCTATCCAT CTTTGGTATTTGCTTCCACCAACAGCCTCCATTTCTAGGGCGCTCAGCATGTATGAAGAAGCATTTCAGAATACCTCTGACAGTGACAGATATGCCTGCT CCCCACTTCCTTCGTATCTGGAGGGTTCTGGCTGTGTGATAGCGGAGGAGCAAAACTCACAGACACCACTTCGAGATGTCTGCTTTCACCTTCTAAAACT CTACAGTGACAGCATACGTGAGAAGGCTGTTCGAGAGCTGCTTACCCGGCACTGCCAGCTGTTGGAGACCCCTGAATCTTGGGCTAAAGAGACTTTCCTT ACCCAGAAGCTCCGTGTACCTGCCAAATGGATCCACGAGGCCAAAGCTGTGCGAGCACACATGGAATCTGACAAGCACTTAGAGGCCCTTTGCTTATTTA AGGCTGAGCACTGGAACCGCTGCCACAAGCTCATCATCCGACACTTAGCTTCTGATGCCATCATTAATGAGAACTATGACTACCTGAAGGGGTTCTTGGA AGACCTGGCACCTCCAGAGCGCAGCAGCCTAATTCAGGATTGGGAAACATCTGGGCTTGTTTACCTGGACTATATTAGAGTCATTGAAATGCTCCGCCAT ATACAGCAGGTGGATTGCTCAGGTAATGACCTGGAGCAGTTACACATCAAAGTGACTTCACTGTGCAGTCGGATAGAGCAGATTCAGTGTTACAGTGCTA AAGATCGCCTGGCTCAGTCAGACATGGCCAAACGTGTAGCCAACCTGCTGCGCGTGGTGCTGAGTCTGCATCATCCTCCTGATAGAACCTCCGACTCAAC ACCAGACCCTCAGCGAGTCCCTTTGCGCCTCTTGGCTCCCCACATTGGCCGGCTTCCCATGCCTGAGGACTATGCCATGGACGAACTGCGCAGCCTTACC CAGTCCTATCTGCGAGAACTGGCTGTTGGGAGCCTGTGAGCCCCAGGCACTTTGCATCACAGTCACATGCCCATTCACACCACACAGAGGTTCCCTGCCT TGTTTGGATTGGCACTGTTTGCCATTCTCTGGGTTGGCTGTGGCATCTACCCTCCCTCCCTGCTGCCAGAAGCAGCATCCTCCACTTGTTCAGGGCTTTT CTTAATACTGAACGTAGCATAAGGGCTTCTGGAACCCAGAAGAGGAGACAGTTTACCATCCTCAAGATCATTCAGTGTTTTTCCTTTAAAAAAATGGTCA ATAAAGCTCCTTTGGCAGAATCCCCCAAAGAACCAGGGTATTCTTTTTCCATCCCTAGCCATTCTGGATCTTGTGACCCTCCATGCCAACCAGCTTCCCT ACTCCTACCCTGGCCCTTTTATACTAGGACTCCTTAGGAGGAGTGAGACAGGTGATAATGGATCCTTAACAGATGAACTATCCACAGAAGGAAGAGGGAT CCGTCTCTTAAGTAATTGGTTAGTTAACACTGAATTTTGGAGGCAAAGGAGGGTTGGCCTGAGTTAGGAAACAAAATGGGATCTTTCTGACACACTTAGG GCAGAAGTGAATGCCTGTCACGGAGGGATTGATCTTCAGGGCTGTTTTTGTTCCTGCCTTTAGAGTTCCATGAACACCATACCTTTGCTACTACTATGTG CAGGAACCCTTGGTCACATGTGACATGTCTGTGGGAAGCTCCCAGAGTTTGGTTTGGTCCCTGGTTTTCAGTCTTGCTGAGACTCTGTCTGGATTTGCCT GCAGAGTTTGGATAAAAAATGGCAGGTTGGGTAACCCTCCCTGTTCATCCCATGTTAGCTCCAAAGCATTTCCCACCCTCCATCTACCCCTTCCAGAAGC AAAAACAAACCATGACTGAGGCAGGCATGGAGTTGGGCGTTAGGGGCAGGCAGAGGGCCTTTGCTACACTGCTGACAGCTATAGGGAGCCCCAGGTAATG GCATGAGATAGCTGGTGTTAGGGCTATCTCAGGCAATATGGCCACACCTGGGTCTTTATGCATGAAGATAATGTAAAGGTTTTTATTAAAAAATATATAT ATGTATAAATAAATGATCTAGATATTTTCCTCTTTTTCTGAAGCTACTTTCTTAAAAAATAAATAAAATGTTTATAGCATTCCTGGTA

NUP98.F1 (forward primer)
NUP98.R1 (reverse primer)
Single exon skipping

Frame 0

PSSAGGPGQGKGRIVTMPFWGRPSDWPELPQPE SRRSKEGGGVSMLRHHPSRHPAGASQSSHSQAHF ERPCVTSRHAPANRGGEGRDSTALSPLLPCASP NSFCPSSSLSPLPPSVRFQKTRCPMNNRVDPEW RPRPPIRGRRGRSVRNEPLTPGGV*RSRALCALR PKRRSVAGVVAAAATVSWGPRAAL*AAGGSRGL LTLPLPHRTALSETKTHFEDV*QIIWNTLWGWH RWLWHNFNIWTEYWLWHY*WRGIWNICIWF*QQY WRPLWKFTD*TRRIVWNQFI*PASYLHKHWLWV WYVNRNSKYLVWNCKHRDQSLLIPKQCLCTK*T NWLWQFWNQY*QWRTLWNHKYHL*SFWQHIWLPL WAK*FYSCSYWDYY*I*PSNWYRYYGQSWS*H* HKYQAPVYYCYERI*KQVTRGTSFRGLSG*QEG PTEPGGSRYHNWLVWVFSSHFQRNRTLQLLHH*F RLCIWSEQNCLWN*YNWIWNKSRWSLWPTESAD YQPLQQTIWPGYNHPEHWLFLW*YQHHRTAKHQ HHGIIWSNPSLTAWRSFWDSYKHQHWDSIWNRNR SLWADQYWIWCCWFDPVWQ*QAYYIWKQHNQCT FIWYNQWRALWFWHKYQWE*YFWK*TSTWDSWN WAWCRIWNSSWCWTGIFVWEQPT*DWRASWYRSL WGPWI*YYDSHFGLWSPPGPSSFDRSKCFCCPA GCSPAAHQ*SNILTFWRLSSLPESDVRP*EEGR EIETNKSSSPEGSYYTYSL*TDTPPCH*SPAKGF TNNRHSQVTSL*WAG*R*TIPSQWSIHAQEEH* EVGFEEP***QSLFSC*S*FRKSSFTI*ISRKW REI*FPKQTC**ESPAGWR*RFPCFTFLY*PYCQ TYSSNPRKCWK*TQQQQQCG*YHCCIKHACCFA KWAGRKQ*RNVFS**VTSG*PRRNRK*FLPYAP SRYYSH*GWLLYYSIYG*PC*NYQ*KRRVHCL*F HYWSERLWFNLF*RRCEFDKSKFG*YCAYPEER SSCLLR**PKTTCG*RAK*EG*SYIGWSLANR* NISLFNKEPRSPC*YQL*RKIGSSFKETGSSIQR IPA*NWFLGV*GLPFF*VWPSGF**RGGGASV* N*YKEVEDCSFASCKPDYALADGS*WQTCTSTS EPEPRGGAVREGCGTGQ*HGRYHPGASFGYHVRR EHA*GSGTCVCLNTYCIFTGN*STCLTDHESII AY**RRCRYGTGSTLQSPAFQSRYFSRNLFSQT PHFSIPLVENSFTSWWVTTIKIYKWSFSFTKCLC ARMSYSQSSIFNEYPIHILLVCPSTPDFCVHNA QPSP*GSVENSGYT*ATRPSPS*KVCHLWQGKT LDGHGPIHGTLISCWLGPQLDSC**WRTAEWLS* TRKSSDCRFHGVWIPAQSSSC*TPN*VPIQSSL RKTQFETKKAR*RHEIISDTSGAQIKTQHCPCG *TVSSHCPQSGSCCHS*LCRLG*RSIRRLTRSTN CEALEPDMDTM*SPMGPPEGA*QPAK*TP*IHS NSGAKKSFLPLAILYCHTSD*RGSLLNPKKQPC GGCIQLPHRQKDQ*GLLSGPAVRGSSSCSSFISV CG*PVSPGAAHHAVGGLASAPSRLLHPG*ETAH LCSVGWKTGVAALRKEANKRVLPVGLETLPGYP SLVFASTNSLHF*GAQHV*RSISEYL*Q*QICLL PTSFVSGGFWLCDSGGAKLTDTTSRCLLSPSKT LQ*QHT*EGCSRAAYPALPAVGDP*ILG*RDFP YPEAPCTCQMDPRGQSCASTHGI*QALRGPLLI* G*ALEPLPQAHHPTLSF*CHH**EL*LPEGVLG RPGTSRAQQPNSGLGNIWACLPGLY*SH*NAPP YTAGGLLR**PGAVTHQSDFTVQSDRADSVLQC* RSPGSVRHGQTCSQPAARGAESASSS**NLRLN TRPSASPFAPLGSPHWPASHA*GLCHGRTAQPY PVLSARTGCWEPVSPRHFASQSHAHSHHTEVPCL VWIGTVCHSLGWLWHLPSLPAARSSILHLFRAF LNTERSIRASGTQKRRQFTILKIIQCFSFKKMV NKAPLAESPKEPGYSFSIPSHSGSCDPPCQPASL LLPWPFYTRTP*EE*DR**WILNR*TIHRRKRD PSLK*LVS*H*ILEAKEGWPELGNKMGSF*HT* GRSECLSRRD*SSGLFLFLPLEFHEHHTFATTMC RNPWSHVTCLWEAPRVWFGPWFSVLLRLCLDLP AEFG*KMAGWVTLPVHPMLAPKHFPPSIYPFQK QKQTMTEAGMELGVRGRQRAFATLLTAIGSPR*W HEIAGVRAISGNMATPGSLCMKIM*RFLLKNIY MYK*MI*IFSSFSEATFLKNK*NVYSIPG

Frame 1

PAAPADRGKERVE*LPCHSGAVPLIGPSSLSPS RGAPRKGAESLCCVTTLPDTPPVLPNLAIHKPT SRGPV*RHDTLPPTAAARGGTPRPSHRSYPVPPR TPSAPPLPSRPFPLQFGFKRRVAQ*ITGSTQSG GRVHQFADGEGGASATSL*RRAACDAVGPSARC ARSGGRWQGW*RRRRRFRGGRALLCERRVAAGDS *HFPFPTEPRFLKQRLILKMFNKSFGTPFGGGT GGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNN TGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGF GTSTGTANTLFGTASTGTSLFSSQNNAFAQNKP TGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSL FGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTN ISTKHQCITAMKEYESKSLEELRLEDYQANRKG PQNQVGAGTTTGLFGSSPATSSATGLFSSSTTN SGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQT TSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTN TMGLFGVTQASQPGGLFGTATNTSTGTAFGTGT GLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAP SFGTTSGGLFGFGTNTSGNSIFGSKPAPGTLGT GLGAGFGTALGAGQASLFGNNQPKIGGPLGTGA FGAPGFNTTTATLGFGAPQAPVALTDPNASAAQQ AVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEE RLKPTNPAAQKALTTPTHYKLTPRPATRVRPKA LQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIK KLVLKNLNNSNLFSPVNRDSENLASPSEYPENG ERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIA KPIPQTPESAGNKHSNSNSVDDTIVALNMRAALR NGLEGSSEETSFHDESLQDDREEIENNSYHMHP AGIILTKVGYYTIPSMDDLAKITNEKGECIVSD FTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKE VVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDK TSRCLIKSPDRLADINYEGRLEAVSRKQGAQFK EYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSK TSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLE ESMPEDQEPVSASTHIASSLGINPHVLQIMKASL LTDEEDVDMALDQRFSRLPSKADTSQEICSPRL PISASHSSKTRSLVGGLLQSKFTSGAFLSPSVS VQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMP SPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKL LMDMALFMGRSFRVGWGPNWTLANSGEQLNGSH ELENHQIADSMEFGFLPNPVAVKPLTESPFKVHL EKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVD ELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQ IVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQ ILERRRAFSRWLSCTATPQIEEEVSLTQKNSPV EAVFSYLTGKRISEACSLAQQSGDHRLALLLSQ FVGSQSVRELLTMQLVDWHQLQADSFIQDERLRI FALLAGKPVWQLSEKKQINVCSQLDWKRSLAIH LWYLLPPTASISRALSMYEEAFQNTSDSDRYAC SPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKL YSDSIREKAVRELLTRHCQLLETPESWAKETFL TQKLRVPAKWIHEAKAVRAHMESDKHLEALCLF KAEHWNRCHKLIIRHLASDAIINENYDYLKGFLE DLAPPERSSLIQDWETSGLVYLDYIRVIEMLRH IQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSA KDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDST PDPQRVPLRLLAPHIGRLPMPEDYAMDELRSLT QSYLRELAVGSL*APGTLHHSHMPIHTTQRFPA LFGLALFAILWVGCGIYPPSLLPEAASSTCSGLF LILNVA*GLLEPRRGDSLPSSRSFSVFPLKKWS IKLLWQNPPKNQGILFPSLAILDLVTLHANQLP YSYPGPFILGLLRRSETGDNGSLTDELSTEGRGI RLLSNWLVNTEFWRQRRVGLS*ETKWDLSDTLR AEVNACHGGIDLQGCFCSCL*SSMNTIPLLLLC AGTLGHM*HVCGKLPEFGLVPGFQSC*DSVWICL QSLDKKWQVG*PSLFIPC*LQSISHPPSTPSRS KNKP*LRQAWSWALGAGRGPLLHC*QL*GAPGN GMR*LVLGLSQAIWPHLGLYA*R*CKGFY*KIYI CINK*SRYFPLFLKLLS*KINKMFIAFLV

Frame 2

QQRRRTGARKGSNSYHAILGPSL*LARAPSARV AALQGRGRSLYVASPPFPTPRRCFPI*PFTSPL REALCDVTTRSRQPRRRGAGLHGPLTAPTLCLP ELLLPLLFPLAPSPFSSVSKDALPNE*QGRPRVA AASTNSRTARAERPQRASDAGRRVTQSGPLRAA PEAAVGGRGGSGGGDGFVGAARCSVSGGWQQGT PDTSPSPPNRAF*NKDSF*RCLTNHLEHPLGVAQ VALAQLQHLDRILALALLVEGHLEHLHLVLATI LEASLEIHRLNQEDCLEPVHLASQLPPQALALG LVRQQEQQIPCLELQAQGPVSSHPKTMPLHKINQ LALAILEPVLAVEDSLEPQIPPLILLAAHLAPS LGQVVLQLLLLGLLLNLTLQLVQILWSKLELAL T*VPSTSVLLL*KNMKASH*RNFV*RIIRLTGRA HRTRWEQVPQLACLGLLQPLPAQQDSSAPPPLI QALHMVRTKLPLELVQLDLEQIQVVSLANRISR LPASSANHLARLQPPRTLAFPLVIPAP*DSQAPT PWDYLE*PKPHSLEVFLGQLQTPALGQHLEQEQ VSLGRPILDLVLLVRPCLAITSLLHLEAAQPVH LHLVQPVAGSLVLAQIPVGIVFLEVNQHLGLLEL GLVQDLEQLLVLDRHLCLGTTNLRLEGLLVQEP LGPLDLILRQPLWALEPPRPQ*L*QIQMLLLPS RLFSSSTSIV*HTHLLETLLSSGIRCQTLRRRKR D*NQQIQQPRRLLLHLLIIN*HPALPLESGQRL YKQQAQPSHISLMGWMTMNHP*PMEHSCPRRAL RSWF*RTLIIAISFLLLIVIQKI*LHHLNIQKME RDLVS*ANLLMRITSRMEMKIPLFHIFILTLLP NLFLKPQKVLEINTATATVWMIPLLH*TCVLLC EMGWKEAVKKRLFMMSHFRMTEKK*KIILTICTQ QVLFSLRLVTILFHLWMTLLKLPMKKESALSLI SLLVGKVMVQSILKEM*I*QI*IWMILCISGGK K*LST*MITKNHLWVKG*IGRLKLHWMEFGQQIK HLVV**RAQIALLISTMKEDWKQFQGNRELNSK NTGLKLVLGCLRSPIFLSMAFRILMKRRRSIRL KLVQRS*RLLLCLLQARLRPCRWLLMANLHLHLR ARAQRWSS*GGLWNWTVTW*ISPRSQFWIPC*K RACLRIRNLCLPQHILHLHWELIHMSYRS*KHH CLLMKKM*IWHWINASVACLPKQILLKKSVLPDS PFQHPTRRKLVH*LVGYYNQNLQVELFFHQVSL CKNVVLPEQHL**ISHPHPLGLSLHP*LLCSQC PAQPLRFR*KQWVHVGN*A*SLVKSLSPMARENS *WTWPYSWDAHFVLVGAPTGLLLIVENS*MALM N*KIIRLPIPWSLDSCPIQ*LLNP*LSPHSKFT *KNSV*DKESQMKT*NYIRHLWSSN*NTALSMWM NCVLSLSPIWELLSFMTMQIGLKKHQETYQKHK L*STGA*HGHYVKPYGAT*RSLTAS*MNPVNTF KFWSEEELSPAGYPVLPHLRLKRKSP*PKKTALW RLYSATSQAKGSVRPALWPSSQGIIVLLFFYLS LWVASQSGSCSPCSWWTGISSKQTPSSRMRDCA SLLCWLENRCGSSQKRSK*TCAPSWIGNAPWLSI FGICFHQQPPFLGRSACMKKHFRIPLTVTDMPA PHFLRIWRVLAV**RRSKTHRHHFEMSAFTF*N STVTAYVRRLFESCLPGTASCWRPLNLGLKRLSL PRSSVYLPNGSTRPKLCEHTWNLTST*RPFAYL RLSTGTAATSSSSDT*LLMPSLMRTMTT*RGSW KTWHLQSAAA*FRIGKHLGLFTWTILESLKCSAI YSRWIAQVMTWSSYTSK*LHCAVG*SRFSVTVL KIAWLSQTWPNV*PTCCAWC*VCIILLIEPPTQ HQTLSESLCASWLPTLAGFPCLRTMPWTNCAALP SPICENWLLGACEPQALCITVTCPFTPHRGSLP CLDWHCLPFSGLAVASTLPPCCQKQHPPLVQGF S*Y*T*HKGFWNPEEETVYHPQDHSVFFL*KNGQ *SSFGRIPQRTRVFFFHP*PFWIL*PSMPTSFP TPTLALLY*DSLGGVRQVIMDP*QMNYPQKEEG SVS*VIG*LTLNFGGKGGLA*VRKQNGIFLTHLG QK*MPVTEGLIFRAVFVPAFRVP*TPYLCYYYV QEPLVTCDMSVGSSQSLVWSLVFSLAETLSGFA CRVWIKNGRLGNPPCSSHVSSKAFPTLHLPLPEA KTNHD*GRHGVGR*GQAEGLCYTADSYREPQVM A*DSWC*GYLRQYGHTWVFMHEDNVKVFIKKYI YV*INDLDIFLFF*SYFLKK*IKCL*HSW

Sequence NUP98.eAug05

GGGGTAATTGATTTTAAATCACTCTAGCAAATCTGCTACCTTACCTCACCATAGAATGGGCTGAATCTAATAATTGTTGTATCATATTCTGAATAAAGTA AATCTGATTTAGAATCTATTTCTGTTTGGTATAATTTAATGCTGCTTTCCTGATCTTTCTGCTGTCTACAGAGCCAGAGCCCAGAGGTGGAGCAGTTAGG GAGGGTTGTGGAACTGGACAGTGACATGGTAGATATCACCCAGGAGCCAGTTTTGGATACCATGTTAGAAGAGAGCATGCCTGAGGATCAGGAACCTGTG TCTGCCTCAACACATATTGCATCTTCACTGGGAATTAATCCACATGTCTTACAGATCATGAAAGCATCATTGCTTACTGATGAAGAAGATGTAGATATGG CACTGGATCAACGCTTCAGTCGCCTGCCTTCCAAAGCAGATACTTCTCAAGAAATCTGTTCTCCCAGACTCCCCATTTCAGCATCCCACTCGTCGAAAAC TCGTTCACTAGTTGGTGGGTTACTACAATCAAAATTTACAAGTGGAGCTTTTCTTTCACCAAGTGTCTCTGTGCAAGAATGTCGTACTCCCAGAGCAGCA TCTTTAATGAATATCCCATCCACATCCTCTTGCCTAACTGAGTCCCCATTCAAAGTTCACTTAGAAAAACTCAGTTTGAGACAAAGAAAGCCAGATGAAG ACATGAAATTATATCAGACACCTCTGGAGCTCAAATTAAAACACAGCACTGTCCATGTGGATGAACTGTGTCCTCTCATTGTCCCCAATCTGGGAGTTGC TGTCATTCATGACTATGCAGATTGGGTTAAAGAAGCATCAGGAGACTTACCAGAAGCACAAATTGTGAAGCACTGGAGCCTGACATGGACACTATGTGAA GCCCTATGGGGCCACCTGAAGGAGCTTGACAGCCAGCTAAATGAACCCCGTGAATACATTCAAATTCTGGAGCGAAGAAGAGCTTTCTCCCGCTGGCTAT CCTGTACTGCCACACCTCAGATTGAAGAGGAAGTCTCCTTAACCCAAAAAAACAGCCCTGTGGAGGCTGTATTCAGCTACCTCACAGGCAAAAGGATCAG TGAGGCCTGCTCTCTGGCCCAGCAGTCAGGGGATCATCGTCTTGCTCTTCTTTTATCTCAGTTTGTGGGTAGCCAGTCAGTCCGGGAGCTGCTCACCATG CAGTTGGTGGACTGGCATCAGCTCCAAGCAGACTCCTTCATCCAGGATGAGAGACTGCGCATCTTTGCTCTGTTGGCTGGAAAACCGGTGTGGCAGCTCT CAGAAAAGAAGCAAATAAACGTGTGCTCCCAGTTGGATTGGAAACGCTCCCTGGCTATCCATCTTTGGTATTTGCTTCCACCAACAGCCTCCATTTCTAG GGCGCTCAGCATGTATGAAGAAGCATTTCAGAATACCTCTGACAGTGACAGATATGCCTGCTCCCCACTTCCTTCGTATCTGGAGGGTTCTGGCTGTGTG ATAGCGGAGGAGCAAAACTCACAGACACCACTTCGAGATGTCTGCTTTCACCTTCTAAAACTCTACAGTGACAGACATTATGATCTCAACCAGCTGCTGG AGCCTCGAAGCATAACAGCAGATCCTTTGGACTACCGCCTAAGCTGGCACTTGTGGGAAGTGCTGAGGGCTCTTAACTACACCCATCTCTCAGCGCAGTG TGAAGGTGTGCTACAGGCCAGTTACGCTGGCCAGCTTGAAAGTGAGGGGCTCTGGGAGTGGGCCATCTTTGTCCTCCTGCACATTGACAACTCAGGCATA CGTGAGAAGGCTGTTCGAGAGCTGCTTACCCGGCACTGCCAGCTGTTGGAGACCCCTGAATCTTGGGCTAAAGAGACTTTCCTTACCCAGAAGCTCCGTG TACCTGCCAAATGGATCCACGAGGCCAAAGCTGTGCGAGCACACATGGAATCTGACAAGCACTTAGAGGCCCTTTGCTTATTTAAGGCTGAGCACTGGAA CCGCTGCCACAAGCTCATCATCCGACACTTAGCTTCTGATGCCATCATTAATGAGAACTATGACTACCTGAAGGGGTTCTTGGAAGACCTGGCACCTCCA GAGCGCAGCAGCCTAATTCAGGATTGGGAAACATCTGGGCTTGTTTACCTGGACTATATTAGAGTCATTGAAATGCTCCGCCATATACAGCAGGTGGATT GCTCAGGTAATGACCTGGAGCAGTTACACATCAAAGTGACTTCACTGTGCAGTCGGATAGAGCAGATTCAGTGTTACAGTGCTAAAGATCGCCTGGCTCA GTCAGACATGGCCAAACGTGTAGCCAACCTGCTGCGCGTGGTGCTGAGTCTGCATCATCCTCCTGATAGAACCTCCGACTCAACACCAGACCCTCAGCGA GTCCCTTTGCGCCTCTTGGCTCCCCACATTGGCCGGCTTCCCATGCCTGAGGACTATGCCATGGACGAACTGCGCAGCCTTACCCAGTCCTATCTGCGAG AACTGGCTGTTGGGAGCCTGTGAGCCCCAGGCACTTTGCATCACAGTCACATGCCCATTCACACCACACAGAGGTTCCCTGCCTTGTTTGGATTGGCACT GTTTGCCATTCTCTGGGTTGGCTGTGGCATCTACCCTCCCTCCCTGCTGCCAGAAGCAGCATCCTCCACTTGTTCAGGGCTTTTCTTAATACTGAACGTA GCATAAGGGCTTCTGGAACCCAGAAGAGGAGACAGTTTACCATCCTCAAGATCATTCAGTGTTTTTCCTTTAAAAAAATGGTCAATAAAGCTCCTTTGGC AGAATCCCCCAAAGAACCAGGGTATTCTTTTTCCATCCCTAGCCATTCTGGATCTTGTGACCCTCCATGCCAACCAGCTTCCCTACTCCTACCCTGGCCC TTTTATACTAGGACTCCTTAGGAGGAGTGAGACAGGTGATAATGGATCCTTAACAGATGAACTATCCACAGAAGGAAGAGGGATCCGTCTCTTAAGTAAT TGGTTAGTTAACACTGAATTTTGGAGGCAAAGGAGGGTTGGCCTGAGTTAGGAAACAAAATGGGATCTTTCTGACACACTTAGGGCAGAAGTGAATGCCT GTCACGGAGGGATTGATCTTCAGGGCTGTTTTTGTTCCTGCCTTTAGAGTTCCATGAACACCATACCTTTGCTACTACTATGTGCAGGAACCCTTGGTCA CATGTGACATGTCTGTGGGAAGCTCCCAGAGTTTGGTTTGGTCCCTGGTTTTCAGTCTTGCTGAGACTCTGTCTGGATTTGCCTGCAGAGTTTGGATAAA AAATGGCAGGTTGGGTAACCCTCCCTGTTCATCCCATGTTAGCTCCAAAGCATTTCCCACCCTCCATCTACCCCTTCCAGAAGCAAAAACAAACCATGAC TGAGGCAGGCATGGAGTTGGGCGTTAGGGGCAGGCAGAGGGCCTTTGCTACACTGCTGACAGCTATAGGGAGCCCCAGGTAATGGCATGAGATAGCTGGT GTTAGGGCTATCTCAGGCAATATGGCCACACCTGGGTCTTTATGCATGAAGATAATGTAAAGGTTTTTATTAAAAAATATATATATGTATAAATAAATGA TCTAGATATTTTCCTCTTTTTCTGAAGCTACTTTCTTAAAAAATAAATAAAATGTTTATAGCATTCCTGGTA

NUP98.F1 (forward primer)
NUP98.R1 (reverse primer)
Single exon skipping

Frame 0

GVIDFKSL*QICYLTSP*NGLNLIIVVSYSE*S KSDLESISVWYNLMLLS*SFCCLQSQSPEVEQLG RVVELDSDMVDITQEPVLDTMLEESMPEDQEPV SASTHIASSLGINPHVLQIMKASLLTDEEDVDM ALDQRFSRLPSKADTSQEICSPRLPISASHSSKT RSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAA SLMNIPSTSSCLTESPFKVHLEKLSLRQRKPDE DMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVA VIHDYADWVKEASGDLPEAQIVKHWSLTWTLCE ALWGHLKELDSQLNEPREYIQILERRRAFSRWL SCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRIS EACSLAQQSGDHRLALLLSQFVGSQSVRELLTM QLVDWHQLQADSFIQDERLRIFALLAGKPVWQL SEKKQINVCSQLDWKRSLAIHLWYLLPPTASISR ALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCV IAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLL EPRSITADPLDYRLSWHLWEVLRALNYTHLSAQC EGVLQASYAGQLESEGLWEWAIFVLLHIDNSGI REKAVRELLTRHCQLLETPESWAKETFLTQKLR VPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWN RCHKLIIRHLASDAIINENYDYLKGFLEDLAPP ERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVD CSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQ SDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQR VPLRLLAPHIGRLPMPEDYAMDELRSLTQSYLR ELAVGSL*APGTLHHSHMPIHTTQRFPALFGLAL FAILWVGCGIYPPSLLPEAASSTCSGLFLILNV A*GLLEPRRGDSLPSSRSFSVFPLKKWSIKLLW QNPPKNQGILFPSLAILDLVTLHANQLPYSYPGP FILGLLRRSETGDNGSLTDELSTEGRGIRLLSN WLVNTEFWRQRRVGLS*ETKWDLSDTLRAEVNA CHGGIDLQGCFCSCL*SSMNTIPLLLLCAGTLGH M*HVCGKLPEFGLVPGFQSC*DSVWICLQSLDK KWQVG*PSLFIPC*LQSISHPPSTPSRSKNKP* LRQAWSWALGAGRGPLLHC*QL*GAPGNGMR*LV LGLSQAIWPHLGLYA*R*CKGFY*KIYICINK* SRYFPLFLKLLS*KINKMFIAFLV

Frame 1

G*LILNHSSKSATLPHHRMG*I**LLYHILNKV NLI*NLFLFGII*CCFPDLSAVYRARAQRWSS* GGLWNWTVTW*ISPRSQFWIPC*KRACLRIRNLC LPQHILHLHWELIHMSYRS*KHHCLLMKKM*IW HWINASVACLPKQILLKKSVLPDSPFQHPTRRK LVH*LVGYYNQNLQVELFFHQVSLCKNVVLPEQH L**ISHPHPLA*LSPHSKFT*KNSV*DKESQMK T*NYIRHLWSSN*NTALSMWMNCVLSLSPIWEL LSFMTMQIGLKKHQETYQKHKL*STGA*HGHYVK PYGAT*RSLTAS*MNPVNTFKFWSEEELSPAGY PVLPHLRLKRKSP*PKKTALWRLYSATSQAKGS VRPALWPSSQGIIVLLFFYLSLWVASQSGSCSPC SWWTGISSKQTPSSRMRDCASLLCWLENRCGSS QKRSK*TCAPSWIGNAPWLSIFGICFHQQPPFL GRSACMKKHFRIPLTVTDMPAPHFLRIWRVLAV* *RRSKTHRHHFEMSAFTF*NSTVTDIMISTSCW SLEA*QQILWTTA*AGTCGKC*GLLTTPISQRS VKVCYRPVTLASLKVRGSGSGPSLSSCTLTTQAY VRRLFESCLPGTASCWRPLNLGLKRLSLPRSSV YLPNGSTRPKLCEHTWNLTST*RPFAYLRLSTG TAATSSSSDT*LLMPSLMRTMTT*RGSWKTWHLQ SAAA*FRIGKHLGLFTWTILESLKCSAIYSRWI AQVMTWSSYTSK*LHCAVG*SRFSVTVLKIAWL SQTWPNV*PTCCAWC*VCIILLIEPPTQHQTLSE SLCASWLPTLAGFPCLRTMPWTNCAALPSPICE NWLLGACEPQALCITVTCPFTPHRGSLPCLDWH CLPFSGLAVASTLPPCCQKQHPPLVQGFS*Y*T* HKGFWNPEEETVYHPQDHSVFFL*KNGQ*SSFG RIPQRTRVFFFHP*PFWIL*PSMPTSFPTPTLA LLY*DSLGGVRQVIMDP*QMNYPQKEEGSVS*VI G*LTLNFGGKGGLA*VRKQNGIFLTHLGQK*MP VTEGLIFRAVFVPAFRVP*TPYLCYYYVQEPLV TCDMSVGSSQSLVWSLVFSLAETLSGFACRVWIK NGRLGNPPCSSHVSSKAFPTLHLPLPEAKTNHD *GRHGVGR*GQAEGLCYTADSYREPQVMA*DSW C*GYLRQYGHTWVFMHEDNVKVFIKKYIYV*IND LDIFLFF*SYFLKK*IKCL*HSW

Frame 2

GN*F*ITLANLLPYLTIEWAESNNCCIIF*IK* I*FRIYFCLV*FNAAFLIFLLSTEPEPRGGAVR EGCGTGQ*HGRYHPGASFGYHVRREHA*GSGTC VCLNTYCIFTGN*STCLTDHESIIAY**RRCRYG TGSTLQSPAFQSRYFSRNLFSQTPHFSIPLVEN SFTSWWVTTIKIYKWSFSFTKCLCARMSYSQSS IFNEYPIHILLPN*VPIQSSLRKTQFETKKAR*R HEIISDTSGAQIKTQHCPCG*TVSSHCPQSGSC CHS*LCRLG*RSIRRLTRSTNCEALEPDMDTM* SPMGPPEGA*QPAK*TP*IHSNSGAKKSFLPLAI LYCHTSD*RGSLLNPKKQPCGGCIQLPHRQKDQ *GLLSGPAVRGSSSCSSFISVCG*PVSPGAAHH AVGGLASAPSRLLHPG*ETAHLCSVGWKTGVAAL RKEANKRVLPVGLETLPGYPSLVFASTNSLHF* GAQHV*RSISEYL*Q*QICLLPTSFVSGGFWLC DSGGAKLTDTTSRCLLSPSKTLQ*QTL*SQPAAG ASKHNSRSFGLPPKLALVGSAEGS*LHPSLSAV *RCATGQLRWPA*K*GALGVGHLCPPAH*QLRH T*EGCSRAAYPALPAVGDP*ILG*RDFPYPEAPC TCQMDPRGQSCASTHGI*QALRGPLLI*G*ALE PLPQAHHPTLSF*CHH**EL*LPEGVLGRPGTS RAQQPNSGLGNIWACLPGLY*SH*NAPPYTAGGL LR**PGAVTHQSDFTVQSDRADSVLQC*RSPGS VRHGQTCSQPAARGAESASSS**NLRLNTRPSA SPFAPLGSPHWPASHA*GLCHGRTAQPYPVLSAR TGCWEPVSPRHFASQSHAHSHHTEVPCLVWIGT VCHSLGWLWHLPSLPAARSSILHLFRAFLNTER SIRASGTQKRRQFTILKIIQCFSFKKMVNKAPLA ESPKEPGYSFSIPSHSGSCDPPCQPASLLLPWP FYTRTP*EE*DR**WILNR*TIHRRKRDPSLK* LVS*H*ILEAKEGWPELGNKMGSF*HT*GRSECL SRRD*SSGLFLFLPLEFHEHHTFATTMCRNPWS HVTCLWEAPRVWFGPWFSVLLRLCLDLPAEFG* KMAGWVTLPVHPMLAPKHFPPSIYPFQKQKQTMT EAGMELGVRGRQRAFATLLTAIGSPR*WHEIAG VRAISGNMATPGSLCMKIM*RFLLKNIYMYK*M I*IFSSFSEATFLKNK*NVYSIPG

Sequence NUP98.aAug05

CCCAGCAGCGCCGGCGGACCGGGGCAAGGAAAGGGTCGAATAGTTACCATGCCATTCTGGGGCCGTCCCTCTGATTGGCCCGAGCTCCCTCAGCCCGAGT CGCGGCGCTCCAAGGAAGGGGGCGGAGTCTCTATGTTGCGTCACCACCCTTCCCGACACCCCGCCGGTGCTTCCCAATCTAGCCATTCACAAGCCCACTT CGAGAGGCCCTGTGTGACGTCACGACACGCTCCCGCCAACCGCGGCGGCGAGGGGCGGGACTCCACGGCCCTCTCACCGCTCCTACCCTGTGCCTCCCCG AACTCCTTCTGCCCCTCCTCTTCCCTCTCGCCCCTTCCCCCTTCAGTTCGGTTTCAAAAGACGCGTTGCCCAATGAATAACAGGGTCGACCCAGAGTGGC GGCCGCGTCCACCAATTCGCGGACGGCGAGGGCGGAGCGTCCGCAACGAGCCTCTGACGCCGGGCGGCGTGTGACGCAGTCGGGCCCTCTGCGCGCTGCG CCCGAAGCGGCGGTCGGTGGCAGGGGTGGTAGCGGCGGCGGCGACGGTTTCGTGGGGGCCGCGCGCTGCTCTGTGAGCGGCGGGTGGCAGCAGGGGACTC CTGACACTTCCCCTTCCCCACCGAACCGCGCTTTCTGAAACAAAGACTCATTTTGAAGATGTTTAACAAATCATTTGGAACACCCTTTGGGGGTGGCACA GGTGGCTTTGGCACAACTTCAACATTTGGACAGAATACTGGCTTTGGCACTACTAGTGGAGGGGCATTTGGAACATCTGCATTTGGTTCTAGCAACAATA CTGGAGGCCTCTTTGGAAATTCACAGACTAAACCAGGAGGATTGTTTGGAACCAGTTCATTTAGCCAGCCAGCTACCTCCACAAGCACTGGCTTTGGGTT TGGTACGTCAACAGGAACAGCAAATACCTTGTTTGGAACTGCAAGCACAGGGACCAGTCTCTTCTCATCCCAAAACAATGCCTTTGCACAAAATAAACCA ACTGGCTTTGGCAATTTTGGAACCAGTACTAGCAGTGGAGGACTCTTTGGAACCACAAATACCACCTCTAATCCTTTTGGCAGCACATCTGGCTCCCTCT TTGGGCCAAGTAGTTTTACAGCTGCTCCTACTGGGACTACTATTAAATTTAACCCTCCAACTGGTACAGATACTATGGTCAAAGCTGGAGTTAGCACTAA CATAAGTACCAAGCACCAGTGTATTACTGCTATGAAAGAATATGAAAGCAAGTCACTAGAGGAACTTCGTTTAGAGGATTATCAGGCTAACAGGAAGGGC CCACAGAACCAGGTGGGAGCAGGTACCACAACTGGCTTGTTTGGGTCTTCTCCAGCCACTTCCAGCGCAACAGGACTCTTCAGCTCCTCCACCACTAATT CAGGCTTTGCATATGGTCAGAACAAAACTGCCTTTGGAACTAGTACAACTGGATTTGGAACAAATCCAGGTGGTCTCTTTGGCCAACAGAATCAGCAGAC TACCAGCCTCTTCAGCAAACCATTTGGCCAGGCTACAACCACCCAGAACACTGGCTTTTCCTTTGGTAATACCAGCACCATAGGACAGCCAAGCACCAAC ACCATGGGATTATTTGGAGTAACCCAAGCCTCACAGCCTGGAGGTCTTTTTGGGACAGCTACAAACACCAGCACTGGGACAGCATTTGGAACAGGAACAG GTCTCTTTGGGCAGACCAATACTGGATTTGGTGCTGTTGGTTCGACCCTGTTTGGCAATAACAAGCTTACTACATTTGGAAGCAGCACAACCAGTGCACC TTCATTTGGTACAACCAGTGGCGGGCTCTTTGGTTTTGGCACAAATACCAGTGGGAATAGTATTTTTGGAAGTAAACCAGCACCTGGGACTCTTGGAACT GGGCTTGGTGCAGGATTTGGAACAGCTCTTGGTGCTGGACAGGCATCTTTGTTTGGGAACAACCAACCTAAGATTGGAGGGCCTCTTGGTACAGGAGCCT TTGGGGCCCCTGGATTTAATACTACGACAGCCACTTTGGGCTTTGGAGCCCCCCAGGCCCCAGTAGCTTTGACAGATCCAAATGCTTCTGCTGCCCAGCA GGCTGTTCTCCAGCAGCACATCAATAGTCTAACATACTCACCTTTTGGAGACTCTCCTCTCTTCCGGAATCCGATGTCAGACCCTAAGAAGAAGGAAGAG AGATTGAAACCAACAAATCCAGCAGCCCAGAAGGCTCTTACTACACCTACTCATTATAAACTGACACCCCGCCCTGCCACTAGAGTCCGGCCAAAGGCTT TACAAACAACAGGCACAGCCAAGTCACATCTCTTTGATGGGCTGGATGACGATGAACCATCCCTAGCCAATGGAGCATTCATGCCCAAGAAGAGCATTAA GAAGTTGGTTTTGAAGAACCTTAATAATAGCAATCTCTTTTCTCCTGTTAATCGTGATTCAGAAAATCTAGCTTCACCATCTGAATATCCAGAAAATGGA GAGAGATTTAGTTTCCTAAGCAAACCTGTTGATGAGAATCACCAGCAGGATGGAGATGAAGATTCCCTTGTTTCACATTTTTATACTAACCCTATTGCCA AACCTATTCCTCAAACCCCAGAAAGTGCTGGAAATAAACACAGCAACAGCAACAGTGTGGATGATACCATTGTTGCATTAAACATGCGTGCTGCTTTGCG AAATGGGCTGGAAGGAAGCAGTGAAGAAACGTCTTTTCATGATGAGTCACTTCAGGATGACCGAGAAGAAATAGAAAATAATTCTTACCATATGCACCCA GCAGGTATTATTCTCACTAAGGTTGGTTACTATACTATTCCATCTATGGATGACCTTGCTAAAATTACCAATGAAAAAGGAGAGTGCATTGTCTCTGATT TCACTATTGGTCGGAAAGGTTATGGTTCAATCTATTTTGAAGGAGATGTGAATTTGACAAATCTAAATTTGGATGATATTGTGCATATCCGGAGGAAAGA AGTAGTTGTCTACTTAGATGATAACCAAAAACCACCTGTGGGTGAAGGGCTAAATAGGAAGGCTGAAGTTACATTGGATGGAGTTTGGCCAACAGATAAA ACATCTCGTTGTTTAATAAAGAGCCCAGATCGCCTTGCTGATATCAACTATGAAGGAAGATTGGAAGCAGTTTCAAGGAAACAGGGAGCTCAATTCAAAG AATACCGGCCTGAAACTGGTTCTTGGGTGTTTAAGGTCTCCCATTTTTCTAAGTATGGCCTTCAGGATTCTGATGAAGAGGAGGAGGAGCATCCGTCTAA AACTAGTACAAAGAAGTTGAAGACTGCTCCTTTGCCTCCTGCAAGCCAGACTACGCCCTTGCAGATGGCTCTTAATGGCAAACCTGCACCTCCACCTCAG AGCCAGAGCCCAGAGGTGGAGCAGTTAGGGAGGGTTGTGGAACTGGACAGTGACATGGTAGATATCACCCAGGAGCCAGTTTTGGATACCATGTTAGAAG AGAGCATGCCTGAGGATCAGGAACCTGTGTCTGCCTCAACACATATTGCATCTTCACTGGGAATTAATCCACATGTCTTACAGATCATGAAAGCATCATT GCTTACTGATGAAGAAGATGTAGATATGGCACTGGATCAACGCTTCAGTCGCCTGCCTTCCAAAGCAGATACTTCTCAAGAAATCTGTTCTCCCAGACTC CCCATTTCAGCATCCCACTCGTCGAAAACTCGTTCACTAGTTGGTGGGTTACTACAATCAAAATTTACAAGTGGAGCTTTTCTTTCACCAAGTGTCTCTG TGCAAGAATGTCGTACTCCCAGAGCAGCATCTTTAATGAATATCCCATCCACATCCTCTTGGTCTGTCCCTCCACCCCTGACTTCTGTGTTCACAATGCC CAGCCCAGCCCCTGAGGTTCCGTTGAAAACAGTGGGTACACGTAGGCAACTAGGCCTAGTCCCTCGTGAAAAGTCTGTCACCTATGGCAAGGGAAAACTC TTGATGGACATGGCCCTATTCATGGGACGCTCATTTCGTGTTGGTTGGGGCCCCAACTGGACTCTTGCTAATAGTGGAGAACAGCTGAATGGCTCTCATG AACTAGAAAATCATCAGATTGCCGATTCCATGGAGTTTGGATTCCTGCCCAATCCAGTAGCTGTTAAACCCCTAACTGAGTCCCCATTCAAAGTTCACTT AGAAAAACTCAGTTTGAGACAAAGAAAGCCAGATGAAGACATGAAATTATATCAGACACCTCTGGAGCTCAAATTAAAACACAGCACTGTCCATGTGGAT GAACTGTGTCCTCTCATTGTCCCCAATCTGGGAGTTGCTGTCATTCATGACTATGCAGATTGGGTTAAAGAAGCATCAGGAGACTTACCAGAAGCACAAA TTGTGAAGCACTGGAGCCTGACATGGACACTATGTGAAGCCCTATGGGGCCACCTGAAGGAGCTTGACAGCCAGCTAAATGAACCCCGTGAATACATTCA AATTCTGGAGCGAAGAAGAGCTTTCTCCCGCTGGCTATCCTGTACTGCCACACCTCAGATTGAAGAGGAAGTCTCCTTAACCCAAAAAAACAGCCCTGTG GAGGCTGTATTCAGCTACCTCACAGGCAAAAGGATCAGTGAGGCCTGCTCTCTGGCCCAGCAGTCAGGGGATCATCGTCTTGCTCTTCTTTTATCTCAGT TTGTGGGTAGCCAGTCAGTCCGGGAGCTGCTCACCATGCAGTTGGTGGACTGGCATCAGCTCCAAGCAGACTCCTTCATCCAGGATGAGAGACTGCGCAT CTTTGCTCTGTTGGCTGGAAAACCGGTGTGGCAGCTCTCAGAAAAGAAGCAAATAAACGTGTGCTCCCAGTTGGATTGGAAACGCTCCCTGGCTATCCAT CTTTGGTATTTGCTTCCACCAACAGCCTCCATTTCTAGGGCGCTCAGCATGTATGAAGAAGCATTTCAGAATACCTCTGACAGTGACAGATATGCCTGCT CCCCACTTCCTTCGTATCTGGAGGGTTCTGGCTGTGTGATAGCGGAGGAGCAAAACTCACAGACACCACTTCGAGATGTCTGCTTTCACCTTCTAAAACT CTACAGTGACAGACATTATGATCTCAACCAGCTGCTGGAGCCTCGAAGCATAACAGCAGATCCTTTGGACTACCGCCTAAGCTGGCACTTGTGGGAAGTG CTGAGGGCTCTTAACTACACCCATCTCTCAGCGCAGTGTGAAGGTGTGCTACAGGCCAGTTACGCTGGCCAGCTTGAAAGTGAGGGGCTCTGGGAGTGGG CCATCTTTGTCCTCCTGCACATTGACAACTCAGGCATACGTGAGAAGGCTGTTCGAGAGCTGCTTACCCGGCACTGCCAGCTGTTGGAGACCCCTGAATC TTGGGCTAAAGAGACTTTCCTTACCCAGAAGCTCCGTGTACCTGCCAAATGGATCCACGAGGCCAAAGCTGTGCGAGCACACATGGAATCTGACAAGCAC TTAGAGGCCCTTTGCTTATTTAAGGCTGAGCACTGGAACCGCTGCCACAAGCTCATCATCCGACACTTAGCTTCTGATGCCATCATTAATGAGAACTATG ACTACCTGAAGGGGTTCTTGGAAGACCTGGCACCTCCAGAGCGCAGCAGCCTAATTCAGGATTGGGAAACATCTGGGCTTGTTTACCTGGACTATATTAG AGTCATTGAAATGCTCCGCCATATACAGCAGGTGGATTGCTCAGGTAATGACCTGGAGCAGTTACACATCAAAGTGACTTCACTGTGCAGTCGGATAGAG CAGATTCAGTGTTACAGTGCTAAAGATCGCCTGGCTCAGTCAGACATGGCCAAACGTGTAGCCAACCTGCTGCGCGTGGTGCTGAGTCTGCATCATCCTC CTGATAGAACCTCCGACTCAACACCAGACCCTCAGCGAGTCCCTTTGCGCCTCTTGGCTCCCCACATTGGCCGGCTTCCCATGCCTGAGGACTATGCCAT GGACGAACTGCGCAGCCTTACCCAGTCCTATCTGCGAGAACTGGCTGTTGGGAGCCTGTGAGCCCCAGGCACTTTGCATCACAGTCACATGCCCATTCAC ACCACACAGAGGTTCCCTGCCTTGTTTGGATTGGCACTGTTTGCCATTCTCTGGGTTGGCTGTGGCATCTACCCTCCCTCCCTGCTGCCAGAAGCAGCAT CCTCCACTTGTTCAGGGCTTTTCTTAATACTGAACGTAGCATAAGGGCTTCTGGAACCCAGAAGAGGAGACAGTTTACCATCCTCAAGATCATTCAGTGT TTTTCCTTTAAAAAAATGGTCAATAAAGCTCCTTTGGCAGAATCCCCCAAAGAACCAGGGTATTCTTTTTCCATCCCTAGCCATTCTGGATCTTGTGACC CTCCATGCCAACCAGCTTCCCTACTCCTACCCTGGCCCTTTTATACTAGGACTCCTTAGGAGGAGTGAGACAGGTGATAATGGATCCTTAACAGATGAAC TATCCACAGAAGGAAGAGGGATCCGTCTCTTAAGTAATTGGTTAGTTAACACTGAATTTTGGAGGCAAAGGAGGGTTGGCCTGAGTTAGGAAACAAAATG GGATCTTTCTGACACACTTAGGGCAGAAGTGAATGCCTGTCACGGAGGGATTGATCTTCAGGGCTGTTTTTGTTCCTGCCTTTAGAGTTCCATGAACACC ATACCTTTGCTACTACTATGTGCAGGAACCCTTGGTCACATGTGACATGTCTGTGGGAAGCTCCCAGAGTTTGGTTTGGTCCCTGGTTTTCAGTCTTGCT GAGACTCTGTCTGGATTTGCCTGCAGAGTTTGGATAAAAAATGGCAGGTTGGGTAACCCTCCCTGTTCATCCCATGTTAGCTCCAAAGCATTTCCCACCC TCCATCTACCCCTTCCAGAAGCAAAAACAAACCATGACTGAGGCAGGCATGGAGTTGGGCGTTAGGGGCAGGCAGAGGGCCTTTGCTACACTGCTGACAG CTATAGGGAGCCCCAGGTAATGGCATGAGATAGCTGGTGTTAGGGCTATCTCAGGCAATATGGCCACACCTGGGTCTTTATGCATGAAGATAATGTAAAG GTTTTTATTAAAAAATATATATATGTATAAATAAATGATCTAGATATTTTCCTCTTTTTCTGAAGCTACTTTCTTAAAAAATAAATAAAATGTTTATAGC ATTCCTGGTA

NUP98.F1 (forward primer)
NUP98.R1 (reverse primer)
Single exon skipping

Frame 0

PSSAGGPGQGKGRIVTMPFWGRPSDWPELPQPE SRRSKEGGGVSMLRHHPSRHPAGASQSSHSQAHF ERPCVTSRHAPANRGGEGRDSTALSPLLPCASP NSFCPSSSLSPLPPSVRFQKTRCPMNNRVDPEW RPRPPIRGRRGRSVRNEPLTPGGV*RSRALCALR PKRRSVAGVVAAAATVSWGPRAAL*AAGGSRGL LTLPLPHRTALSETKTHFEDV*QIIWNTLWGWH RWLWHNFNIWTEYWLWHY*WRGIWNICIWF*QQY WRPLWKFTD*TRRIVWNQFI*PASYLHKHWLWV WYVNRNSKYLVWNCKHRDQSLLIPKQCLCTK*T NWLWQFWNQY*QWRTLWNHKYHL*SFWQHIWLPL WAK*FYSCSYWDYY*I*PSNWYRYYGQSWS*H* HKYQAPVYYCYERI*KQVTRGTSFRGLSG*QEG PTEPGGSRYHNWLVWVFSSHFQRNRTLQLLHH*F RLCIWSEQNCLWN*YNWIWNKSRWSLWPTESAD YQPLQQTIWPGYNHPEHWLFLW*YQHHRTAKHQ HHGIIWSNPSLTAWRSFWDSYKHQHWDSIWNRNR SLWADQYWIWCCWFDPVWQ*QAYYIWKQHNQCT FIWYNQWRALWFWHKYQWE*YFWK*TSTWDSWN WAWCRIWNSSWCWTGIFVWEQPT*DWRASWYRSL WGPWI*YYDSHFGLWSPPGPSSFDRSKCFCCPA GCSPAAHQ*SNILTFWRLSSLPESDVRP*EEGR EIETNKSSSPEGSYYTYSL*TDTPPCH*SPAKGF TNNRHSQVTSL*WAG*R*TIPSQWSIHAQEEH* EVGFEEP***QSLFSC*S*FRKSSFTI*ISRKW REI*FPKQTC**ESPAGWR*RFPCFTFLY*PYCQ TYSSNPRKCWK*TQQQQQCG*YHCCIKHACCFA KWAGRKQ*RNVFS**VTSG*PRRNRK*FLPYAP SRYYSH*GWLLYYSIYG*PC*NYQ*KRRVHCL*F HYWSERLWFNLF*RRCEFDKSKFG*YCAYPEER SSCLLR**PKTTCG*RAK*EG*SYIGWSLANR* NISLFNKEPRSPC*YQL*RKIGSSFKETGSSIQR IPA*NWFLGV*GLPFF*VWPSGF**RGGGASV* N*YKEVEDCSFASCKPDYALADGS*WQTCTSTS EPEPRGGAVREGCGTGQ*HGRYHPGASFGYHVRR EHA*GSGTCVCLNTYCIFTGN*STCLTDHESII AY**RRCRYGTGSTLQSPAFQSRYFSRNLFSQT PHFSIPLVENSFTSWWVTTIKIYKWSFSFTKCLC ARMSYSQSSIFNEYPIHILLVCPSTPDFCVHNA QPSP*GSVENSGYT*ATRPSPS*KVCHLWQGKT LDGHGPIHGTLISCWLGPQLDSC**WRTAEWLS* TRKSSDCRFHGVWIPAQSSSC*TPN*VPIQSSL RKTQFETKKAR*RHEIISDTSGAQIKTQHCPCG *TVSSHCPQSGSCCHS*LCRLG*RSIRRLTRSTN CEALEPDMDTM*SPMGPPEGA*QPAK*TP*IHS NSGAKKSFLPLAILYCHTSD*RGSLLNPKKQPC GGCIQLPHRQKDQ*GLLSGPAVRGSSSCSSFISV CG*PVSPGAAHHAVGGLASAPSRLLHPG*ETAH LCSVGWKTGVAALRKEANKRVLPVGLETLPGYP SLVFASTNSLHF*GAQHV*RSISEYL*Q*QICLL PTSFVSGGFWLCDSGGAKLTDTTSRCLLSPSKT LQ*QTL*SQPAAGASKHNSRSFGLPPKLALVGS AEGS*LHPSLSAV*RCATGQLRWPA*K*GALGVG HLCPPAH*QLRHT*EGCSRAAYPALPAVGDP*I LG*RDFPYPEAPCTCQMDPRGQSCASTHGI*QA LRGPLLI*G*ALEPLPQAHHPTLSF*CHH**EL* LPEGVLGRPGTSRAQQPNSGLGNIWACLPGLY* SH*NAPPYTAGGLLR**PGAVTHQSDFTVQSDR ADSVLQC*RSPGSVRHGQTCSQPAARGAESASSS **NLRLNTRPSASPFAPLGSPHWPASHA*GLCH GRTAQPYPVLSARTGCWEPVSPRHFASQSHAHS HHTEVPCLVWIGTVCHSLGWLWHLPSLPAARSSI LHLFRAFLNTERSIRASGTQKRRQFTILKIIQC FSFKKMVNKAPLAESPKEPGYSFSIPSHSGSCD PPCQPASLLLPWPFYTRTP*EE*DR**WILNR*T IHRRKRDPSLK*LVS*H*ILEAKEGWPELGNKM GSF*HT*GRSECLSRRD*SSGLFLFLPLEFHEH HTFATTMCRNPWSHVTCLWEAPRVWFGPWFSVLL RLCLDLPAEFG*KMAGWVTLPVHPMLAPKHFPP SIYPFQKQKQTMTEAGMELGVRGRQRAFATLLT AIGSPR*WHEIAGVRAISGNMATPGSLCMKIM*R FLLKNIYMYK*MI*IFSSFSEATFLKNK*NVYS IPG

Frame 1

PAAPADRGKERVE*LPCHSGAVPLIGPSSLSPS RGAPRKGAESLCCVTTLPDTPPVLPNLAIHKPT SRGPV*RHDTLPPTAAARGGTPRPSHRSYPVPPR TPSAPPLPSRPFPLQFGFKRRVAQ*ITGSTQSG GRVHQFADGEGGASATSL*RRAACDAVGPSARC ARSGGRWQGW*RRRRRFRGGRALLCERRVAAGDS *HFPFPTEPRFLKQRLILKMFNKSFGTPFGGGT GGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNN TGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGF GTSTGTANTLFGTASTGTSLFSSQNNAFAQNKP TGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSL FGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTN ISTKHQCITAMKEYESKSLEELRLEDYQANRKG PQNQVGAGTTTGLFGSSPATSSATGLFSSSTTN SGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQT TSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTN TMGLFGVTQASQPGGLFGTATNTSTGTAFGTGT GLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAP SFGTTSGGLFGFGTNTSGNSIFGSKPAPGTLGT GLGAGFGTALGAGQASLFGNNQPKIGGPLGTGA FGAPGFNTTTATLGFGAPQAPVALTDPNASAAQQ AVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEE RLKPTNPAAQKALTTPTHYKLTPRPATRVRPKA LQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIK KLVLKNLNNSNLFSPVNRDSENLASPSEYPENG ERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIA KPIPQTPESAGNKHSNSNSVDDTIVALNMRAALR NGLEGSSEETSFHDESLQDDREEIENNSYHMHP AGIILTKVGYYTIPSMDDLAKITNEKGECIVSD FTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKE VVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDK TSRCLIKSPDRLADINYEGRLEAVSRKQGAQFK EYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSK TSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLE ESMPEDQEPVSASTHIASSLGINPHVLQIMKASL LTDEEDVDMALDQRFSRLPSKADTSQEICSPRL PISASHSSKTRSLVGGLLQSKFTSGAFLSPSVS VQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMP SPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKL LMDMALFMGRSFRVGWGPNWTLANSGEQLNGSH ELENHQIADSMEFGFLPNPVAVKPLTESPFKVHL EKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVD ELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQ IVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQ ILERRRAFSRWLSCTATPQIEEEVSLTQKNSPV EAVFSYLTGKRISEACSLAQQSGDHRLALLLSQ FVGSQSVRELLTMQLVDWHQLQADSFIQDERLRI FALLAGKPVWQLSEKKQINVCSQLDWKRSLAIH LWYLLPPTASISRALSMYEEAFQNTSDSDRYAC SPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKL YSDRHYDLNQLLEPRSITADPLDYRLSWHLWEV LRALNYTHLSAQCEGVLQASYAGQLESEGLWEW AIFVLLHIDNSGIREKAVRELLTRHCQLLETPES WAKETFLTQKLRVPAKWIHEAKAVRAHMESDKH LEALCLFKAEHWNRCHKLIIRHLASDAIINENY DYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIR VIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIE QIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHP PDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAM DELRSLTQSYLRELAVGSL*APGTLHHSHMPIH TTQRFPALFGLALFAILWVGCGIYPPSLLPEAA SSTCSGLFLILNVA*GLLEPRRGDSLPSSRSFSV FPLKKWSIKLLWQNPPKNQGILFPSLAILDLVT LHANQLPYSYPGPFILGLLRRSETGDNGSLTDE LSTEGRGIRLLSNWLVNTEFWRQRRVGLS*ETKW DLSDTLRAEVNACHGGIDLQGCFCSCL*SSMNT IPLLLLCAGTLGHM*HVCGKLPEFGLVPGFQSC *DSVWICLQSLDKKWQVG*PSLFIPC*LQSISHP PSTPSRSKNKP*LRQAWSWALGAGRGPLLHC*Q L*GAPGNGMR*LVLGLSQAIWPHLGLYA*R*CK GFY*KIYICINK*SRYFPLFLKLLS*KINKMFIA FLV

Frame 2

QQRRRTGARKGSNSYHAILGPSL*LARAPSARV AALQGRGRSLYVASPPFPTPRRCFPI*PFTSPL REALCDVTTRSRQPRRRGAGLHGPLTAPTLCLP ELLLPLLFPLAPSPFSSVSKDALPNE*QGRPRVA AASTNSRTARAERPQRASDAGRRVTQSGPLRAA PEAAVGGRGGSGGGDGFVGAARCSVSGGWQQGT PDTSPSPPNRAF*NKDSF*RCLTNHLEHPLGVAQ VALAQLQHLDRILALALLVEGHLEHLHLVLATI LEASLEIHRLNQEDCLEPVHLASQLPPQALALG LVRQQEQQIPCLELQAQGPVSSHPKTMPLHKINQ LALAILEPVLAVEDSLEPQIPPLILLAAHLAPS LGQVVLQLLLLGLLLNLTLQLVQILWSKLELAL T*VPSTSVLLL*KNMKASH*RNFV*RIIRLTGRA HRTRWEQVPQLACLGLLQPLPAQQDSSAPPPLI QALHMVRTKLPLELVQLDLEQIQVVSLANRISR LPASSANHLARLQPPRTLAFPLVIPAP*DSQAPT PWDYLE*PKPHSLEVFLGQLQTPALGQHLEQEQ VSLGRPILDLVLLVRPCLAITSLLHLEAAQPVH LHLVQPVAGSLVLAQIPVGIVFLEVNQHLGLLEL GLVQDLEQLLVLDRHLCLGTTNLRLEGLLVQEP LGPLDLILRQPLWALEPPRPQ*L*QIQMLLLPS RLFSSSTSIV*HTHLLETLLSSGIRCQTLRRRKR D*NQQIQQPRRLLLHLLIIN*HPALPLESGQRL YKQQAQPSHISLMGWMTMNHP*PMEHSCPRRAL RSWF*RTLIIAISFLLLIVIQKI*LHHLNIQKME RDLVS*ANLLMRITSRMEMKIPLFHIFILTLLP NLFLKPQKVLEINTATATVWMIPLLH*TCVLLC EMGWKEAVKKRLFMMSHFRMTEKK*KIILTICTQ QVLFSLRLVTILFHLWMTLLKLPMKKESALSLI SLLVGKVMVQSILKEM*I*QI*IWMILCISGGK K*LST*MITKNHLWVKG*IGRLKLHWMEFGQQIK HLVV**RAQIALLISTMKEDWKQFQGNRELNSK NTGLKLVLGCLRSPIFLSMAFRILMKRRRSIRL KLVQRS*RLLLCLLQARLRPCRWLLMANLHLHLR ARAQRWSS*GGLWNWTVTW*ISPRSQFWIPC*K RACLRIRNLCLPQHILHLHWELIHMSYRS*KHH CLLMKKM*IWHWINASVACLPKQILLKKSVLPDS PFQHPTRRKLVH*LVGYYNQNLQVELFFHQVSL CKNVVLPEQHL**ISHPHPLGLSLHP*LLCSQC PAQPLRFR*KQWVHVGN*A*SLVKSLSPMARENS *WTWPYSWDAHFVLVGAPTGLLLIVENS*MALM N*KIIRLPIPWSLDSCPIQ*LLNP*LSPHSKFT *KNSV*DKESQMKT*NYIRHLWSSN*NTALSMWM NCVLSLSPIWELLSFMTMQIGLKKHQETYQKHK L*STGA*HGHYVKPYGAT*RSLTAS*MNPVNTF KFWSEEELSPAGYPVLPHLRLKRKSP*PKKTALW RLYSATSQAKGSVRPALWPSSQGIIVLLFFYLS LWVASQSGSCSPCSWWTGISSKQTPSSRMRDCA SLLCWLENRCGSSQKRSK*TCAPSWIGNAPWLSI FGICFHQQPPFLGRSACMKKHFRIPLTVTDMPA PHFLRIWRVLAV**RRSKTHRHHFEMSAFTF*N STVTDIMISTSCWSLEA*QQILWTTA*AGTCGKC *GLLTTPISQRSVKVCYRPVTLASLKVRGSGSG PSLSSCTLTTQAYVRRLFESCLPGTASCWRPLN LGLKRLSLPRSSVYLPNGSTRPKLCEHTWNLTST *RPFAYLRLSTGTAATSSSSDT*LLMPSLMRTM TT*RGSWKTWHLQSAAA*FRIGKHLGLFTWTIL ESLKCSAIYSRWIAQVMTWSSYTSK*LHCAVG*S RFSVTVLKIAWLSQTWPNV*PTCCAWC*VCIIL LIEPPTQHQTLSESLCASWLPTLAGFPCLRTMP WTNCAALPSPICENWLLGACEPQALCITVTCPFT PHRGSLPCLDWHCLPFSGLAVASTLPPCCQKQH PPLVQGFS*Y*T*HKGFWNPEEETVYHPQDHSV FFL*KNGQ*SSFGRIPQRTRVFFFHP*PFWIL*P SMPTSFPTPTLALLY*DSLGGVRQVIMDP*QMN YPQKEEGSVS*VIG*LTLNFGGKGGLA*VRKQN GIFLTHLGQK*MPVTEGLIFRAVFVPAFRVP*TP YLCYYYVQEPLVTCDMSVGSSQSLVWSLVFSLA ETLSGFACRVWIKNGRLGNPPCSSHVSSKAFPT LHLPLPEAKTNHD*GRHGVGR*GQAEGLCYTADS YREPQVMA*DSWC*GYLRQYGHTWVFMHEDNVK VFIKKYIYV*INDLDIFLFF*SYFLKK*IKCL* HSW