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Sequences

Sequence NUP98.bAug05

CCCAGCAGCGCCGGCGGACCGGGGCAAGGAAAGGGTCGAATAGTTACCATGCCATTCTGGGGCCGTCCCTCTGATTGGCCCGAGCTCCCTCAGCCCGAGT CGCGGCGCTCCAAGGAAGGGGGCGGAGTCTCTATGTTGCGTCACCACCCTTCCCGACACCCCGCCGGTGCTTCCCAATCTAGCCATTCACAAGCCCACTT CGAGAGGCCCTGTGTGACGTCACGACACGCTCCCGCCAACCGCGGCGGCGAGGGGCGGGACTCCACGGCCCTCTCACCGCTCCTACCCTGTGCCTCCCCG AACTCCTTCTGCCCCTCCTCTTCCCTCTCGCCCCTTCCCCCTTCAGTTCGGTTTCAAAAGACGCGTTGCCCAATGAATAACAGGGTCGACCCAGAGTGGC GGCCGCGTCCACCAATTCGCGGACGGCGAGGGCGGAGCGTCCGCAACGAGCCTCTGACGCCGGGCGGCGTGTGACGCAGTCGGGCCCTCTGCGCGCTGCG CCCGAAGCGGCGGTCGGTGGCAGGGGTGGTAGCGGCGGCGGCGACGGTTTCGTGGGGGCCGCGCGCTGCTCTGTGAGCGGCGGGTGGCAGCAGGGGACTC CTGACACTTCCCCTTCCCCACCGAACCGCGCTTTCTGAAACAAAGACTCATTTTGAAGATGTTTAACAAATCATTTGGAACACCCTTTGGGGGTGGCACA GGTGGCTTTGGCACAACTTCAACATTTGGACAGAATACTGGCTTTGGCACTACTAGTGGAGGGGCATTTGGAACATCTGCATTTGGTTCTAGCAACAATA CTGGAGGCCTCTTTGGAAATTCACAGACTAAACCAGGAGGATTGTTTGGAACCAGTTCATTTAGCCAGCCAGCTACCTCCACAAGCACTGGCTTTGGGTT TGGTACGTCAACAGGAACAGCAAATACCTTGTTTGGAACTGCAAGCACAGGGACCAGTCTCTTCTCATCCCAAAACAATGCCTTTGCACAAAATAAACCA ACTGGCTTTGGCAATTTTGGAACCAGTACTAGCAGTGGAGGACTCTTTGGAACCACAAATACCACCTCTAATCCTTTTGGCAGCACATCTGGCTCCCTCT TTGGGCCAAGTAGTTTTACAGCTGCTCCTACTGGGACTACTATTAAATTTAACCCTCCAACTGGTACAGATACTATGGTCAAAGCTGGAGTTAGCACTAA CATAAGTACCAAGCACCAGTGTATTACTGCTATGAAAGAATATGAAAGCAAGTCACTAGAGGAACTTCGTTTAGAGGATTATCAGGCTAACAGGAAGGGC CCACAGAACCAGGTGGGAGCAGGTACCACAACTGGCTTGTTTGGGTCTTCTCCAGCCACTTCCAGCGCAACAGGACTCTTCAGCTCCTCCACCACTAATT CAGGCTTTGCATATGGTCAGAACAAAACTGCCTTTGGAACTAGTACAACTGGATTTGGAACAAATCCAGGTGGTCTCTTTGGCCAACAGAATCAGCAGAC TACCAGCCTCTTCAGCAAACCATTTGGCCAGGCTACAACCACCCAGAACACTGGCTTTTCCTTTGGTAATACCAGCACCATAGGACAGCCAAGCACCAAC ACCATGGGATTATTTGGAGTAACCCAAGCCTCACAGCCTGGAGGTCTTTTTGGGACAGCTACAAACACCAGCACTGGGACAGCATTTGGAACAGGAACAG GTCTCTTTGGGCAGACCAATACTGGATTTGGTGCTGTTGGTTCGACCCTGTTTGGCAATAACAAGCTTACTACATTTGGAAGCAGCACAACCAGTGCACC TTCATTTGGTACAACCAGTGGCGGGCTCTTTGGTTTTGGCACAAATACCAGTGGGAATAGTATTTTTGGAAGTAAACCAGCACCTGGGACTCTTGGAACT GGGCTTGGTGCAGGATTTGGAACAGCTCTTGGTGCTGGACAGGCATCTTTGTTTGGGAACAACCAACCTAAGATTGGAGGGCCTCTTGGTACAGGAGCCT TTGGGGCCCCTGGATTTAATACTACGACAGCCACTTTGGGCTTTGGAGCCCCCCAGGCCCCAGTAGCTTTGACAGATCCAAATGCTTCTGCTGCCCAGCA GGCTGTTCTCCAGCAGCACATCAATAGTCTAACATACTCACCTTTTGGAGACTCTCCTCTCTTCCGGAATCCGATGTCAGACCCTAAGAAGAAGGAAGAG AGATTGAAACCAACAAATCCAGCAGCCCAGAAGGCTCTTACTACACCTACTCATTATAAACTGACACCCCGCCCTGCCACTAGAGTCCGGCCAAAGGCTT TACAAACAACAGGCACAGCCAAGTCACATCTCTTTGATGGGCTGGATGACGATGAACCATCCCTAGCCAATGGAGCATTCATGCCCAAGAAGAGCATTAA GAAGTTGGTTTTGAAGAACCTTAATAATAGCAATCTCTTTTCTCCTGTTAATCGTGATTCAGAAAATCTAGCTTCACCATCTGAATATCCAGAAAATGGA GAGAGATTTAGTTTCCTAAGCAAACCTGTTGATGAGAATCACCAGCAGGATGGAGATGAAGATTCCCTTGTTTCACATTTTTATACTAACCCTATTGCCA AACCTATTCCTCAAACCCCAGAAAGTGCTGGAAATAAACACAGCAACAGCAACAGTGTGGATGATACCATTGTTGCATTAAACATGCGTGCTGCTTTGCG AAATGGGCTGGAAGGAAGCAGTGAAGAAACGTCTTTTCATGATGAGTCACTTCAGGATGACCGAGAAGAAATAGAAAATAATTCTTACCATATGCACCCA GCAGGTATTATTCTCACTAAGGTTGGTTACTATACTATTCCATCTATGGATGACCTTGCTAAAATTACCAATGAAAAAGGAGAGTGCATTGTCTCTGATT TCACTATTGGTCGGAAAGGTTATGGTTCAATCTATTTTGAAGGAGATGTGAATTTGACAAATCTAAATTTGGATGATATTGTGCATATCCGGAGGAAAGA AGTAGTTGTCTACTTAGATGATAACCAAAAACCACCTGTGGGTGAAGGGCTAAATAGGAAGGCTGAAGTTACATTGGATGGAGTTTGGCCAACAGATAAA ACATCTCGTTGTTTAATAAAGAGCCCAGATCGCCTTGCTGATATCAACTATGAAGGAAGATTGGAAGCAGTTTCAAGGAAACAGGGAGCTCAATTCAAAG AATACCGGCCTGAAACTGGTTCTTGGGTGTTTAAGGTCTCCCATTTTTCTAAGTATGGCCTTCAGGATTCTGATGAAGAGGAGGAGGAGCATCCGTCTAA AACTAGTACAAAGAAGTTGAAGACTGCTCCTTTGCCTCCTGCAAGCCAGACTACGCCCTTGCAGATGGCTCTTAATGGCAAACCTGCACCTCCACCTCAG AGCCAGAGCCCAGAGGTGGAGCAGTTAGGGAGGGTTGTGGAACTGGACAGTGACATGGTAGATATCACCCAGGAGCCAGTTTTGGATACCATGTTAGAAG AGAGCATGCCTGAGGATCAGGAACCTGTGTCTGCCTCAACACATATTGCATCTTCACTGGGAATTAATCCACATGTCTTACAGATCATGAAAGCATCATT GCTTACTGATGAAGAAGATGTAGATATGGCACTGGATCAACGCTTCAGTCGCCTGCCTTCCAAAGCAGATACTTCTCAAGAAATCTGTTCTCCCAGACTC CCCATTTCAGCATCCCACTCGTCGAAAACTCGTTCACTAGTTGGTGGGTTACTACAATCAAAATTTACAAGTGGAGCTTTTCTTTCACCAAGTGTCTCTG TGCAAGAATGTCGTACTCCCAGAGCAGCATCTTTAATGAATATCCCATCCACATCCTCTTGGTCTGTCCCTCCACCCCTGACTTCTGTGTTCACAATGCC CAGCCCAGCCCCTGAGGTTCCGTTGAAAACAGTGGGTACACGTAGGCAACTAGGCCTAGTCCCTCGTGAAAAGTCTGTCACCTATGGCAAGGGAAAACTC TTGATGGACATGGCCCTATTCATGGGACGCTCATTTCGTGTTGGTTGGGGCCCCAACTGGACTCTTGCTAATAGTGGAGAACAGCTGAATGGCTCTCATG AACTAGAAAATCATCAGATTGCCGATTCCATGGAGTTTGGATTCCTGCCCAATCCAGTAGCTGTTAAACCCCTAACTGAGTCCCCATTCAAAGTTCACTT AGAAAAACTCAGTTTGAGACAAAGAAAGCCAGATGAAGACATGAAATTATATCAGACACCTCTGGAGCTCAAATTAAAACACAGCACTGTCCATGTGGAT GAACTGTGTCCTCTCATTGTCCCCAATCTGGGAGTTGCTGTCATTCATGACTATGCAGATTGGGTTAAAGAAGCATCAGGAGACTTACCAGAAGCACAAA TTGTGAAGCACTGGAGCCTGACATGGACACTATGTGAAGCCCTATGGGGCCACCTGAAGGAGCTTGACAGCCAGCTAAATGAACCCCGTGAATACATTCA AATTCTGGAGCGAAGAAGAGCTTTCTCCCGCTGGCTATCCTGTACTGCCACACCTCAGATTGAAGAGGAAGTCTCCTTAACCCAAAAAAACAGCCCTGTG GAGGCTGTATTCAGCTACCTCACAGGCAAAAGGATCAGTGAGGCCTGCTCTCTGGCCCAGCAGTCAGGGGATCATCGTCTTGCTCTTCTTTTATCTCAGT TTGTGGGTAGCCAGTCAGTCCGGGAGCTGCTCACCATGCAGTTGGTGGACTGGCATCAGCTCCAAGCAGACTCCTTCATCCAGGATGAGAGACTGCGCAT CTTTGCTCTGTTGGCTGGAAAACCGGTGTGGCAGCTCTCAGAAAAGAAGCAAATAAACGTGTGCTCCCAGTTGGATTGGAAACGCTCCCTGGCTATCCAT CTTTGGTATTTGCTTCCACCAACAGCCTCCATTTCTAGGGCGCTCAGCATGTATGAAGAAGCATTTCAGAATACCTCTGACAGTGACAGATATGCCTGCT CCCCACTTCCTTCGTATCTGGAGGGTTCTGGCTGTGTGATAGCGGAGGAGCAAAACTCACAGACACCACTTCGAGATGTCTGCTTTCACCTTCTAAAACT CTACAGTGACAGCATACGTGAGAAGGCTGTTCGAGAGCTGCTTACCCGGCACTGCCAGCTGTTGGAGACCCCTGAATCTTGGGCTAAAGAGACTTTCCTT ACCCAGAAGCTCCGTGTACCTGCCAAATGGATCCACGAGGCCAAAGCTGTGCGAGCACACATGGAATCTGACAAGCACTTAGAGGCCCTTTGCTTATTTA AGGCTGAGCACTGGAACCGCTGCCACAAGCTCATCATCCGACACTTAGCTTCTGATGCCATCATTAATGAGAACTATGACTACCTGAAGGGGTTCTTGGA AGACCTGGCACCTCCAGAGCGCAGCAGCCTAATTCAGGATTGGGAAACATCTGGGCTTGTTTACCTGGACTATATTAGAGTCATTGAAATGCTCCGCCAT ATACAGCAGGTGGATTGCTCAGGTAATGACCTGGAGCAGTTACACATCAAAGTGACTTCACTGTGCAGTCGGATAGAGCAGATTCAGTGTTACAGTGCTA AAGATCGCCTGGCTCAGTCAGACATGGCCAAACGTGTAGCCAACCTGCTGCGCGTGGTGCTGAGTCTGCATCATCCTCCTGATAGAACCTCCGACTCAAC ACCAGACCCTCAGCGAGTCCCTTTGCGCCTCTTGGCTCCCCACATTGGCCGGCTTCCCATGCCTGAGGACTATGCCATGGACGAACTGCGCAGCCTTACC CAGTCCTATCTGCGAGAACTGGCTGTTGGGAGCCTGTGAGCCCCAGGCACTTTGCATCACAGTCACATGCCCATTCACACCACACAGAGGTTCCCTGCCT TGTTTGGATTGGCACTGTTTGCCATTCTCTGGGTTGGCTGTGGCATCTACCCTCCCTCCCTGCTGCCAGAAGCAGCATCCTCCACTTGTTCAGGGCTTTT CTTAATACTGAACGTAGCATAAGGGCTTCTGGAACCCAGAAGAGGAGACAGTTTACCATCCTCAAGATCATTCAGTGTTTTTCCTTTAAAAAAATGGTCA ATAAAGCTCCTTTGGCAGAATCCCCCAAAGAACCAGGGTATTCTTTTTCCATCCCTAGCCATTCTGGATCTTGTGACCCTCCATGCCAACCAGCTTCCCT ACTCCTACCCTGGCCCTTTTATACTAGGACTCCTTAGGAGGAGTGAGACAGGTGATAATGGATCCTTAACAGATGAACTATCCACAGAAGGAAGAGGGAT CCGTCTCTTAAGTAATTGGTTAGTTAACACTGAATTTTGGAGGCAAAGGAGGGTTGGCCTGAGTTAGGAAACAAAATGGGATCTTTCTGACACACTTAGG GCAGAAGTGAATGCCTGTCACGGAGGGATTGATCTTCAGGGCTGTTTTTGTTCCTGCCTTTAGAGTTCCATGAACACCATACCTTTGCTACTACTATGTG CAGGAACCCTTGGTCACATGTGACATGTCTGTGGGAAGCTCCCAGAGTTTGGTTTGGTCCCTGGTTTTCAGTCTTGCTGAGACTCTGTCTGGATTTGCCT GCAGAGTTTGGATAAAAAATGGCAGGTTGGGTAACCCTCCCTGTTCATCCCATGTTAGCTCCAAAGCATTTCCCACCCTCCATCTACCCCTTCCAGAAGC AAAAACAAACCATGACTGAGGCAGGCATGGAGTTGGGCGTTAGGGGCAGGCAGAGGGCCTTTGCTACACTGCTGACAGCTATAGGGAGCCCCAGGTAATG GCATGAGATAGCTGGTGTTAGGGCTATCTCAGGCAATATGGCCACACCTGGGTCTTTATGCATGAAGATAATGTAAAGGTTTTTATTAAAAAATATATAT ATGTATAAATAAATGATCTAGATATTTTCCTCTTTTTCTGAAGCTACTTTCTTAAAAAATAAATAAAATGTTTATAGCATTCCTGGTA

NUP98.F1 (forward primer)
NUP98.R1 (reverse primer)
Single exon skipping

Frame 0

PSSAGGPGQGKGRIVTMPFWGRPSDWPELPQPE SRRSKEGGGVSMLRHHPSRHPAGASQSSHSQAHF ERPCVTSRHAPANRGGEGRDSTALSPLLPCASP NSFCPSSSLSPLPPSVRFQKTRCPMNNRVDPEW RPRPPIRGRRGRSVRNEPLTPGGV*RSRALCALR PKRRSVAGVVAAAATVSWGPRAAL*AAGGSRGL LTLPLPHRTALSETKTHFEDV*QIIWNTLWGWH RWLWHNFNIWTEYWLWHY*WRGIWNICIWF*QQY WRPLWKFTD*TRRIVWNQFI*PASYLHKHWLWV WYVNRNSKYLVWNCKHRDQSLLIPKQCLCTK*T NWLWQFWNQY*QWRTLWNHKYHL*SFWQHIWLPL WAK*FYSCSYWDYY*I*PSNWYRYYGQSWS*H* HKYQAPVYYCYERI*KQVTRGTSFRGLSG*QEG PTEPGGSRYHNWLVWVFSSHFQRNRTLQLLHH*F RLCIWSEQNCLWN*YNWIWNKSRWSLWPTESAD YQPLQQTIWPGYNHPEHWLFLW*YQHHRTAKHQ HHGIIWSNPSLTAWRSFWDSYKHQHWDSIWNRNR SLWADQYWIWCCWFDPVWQ*QAYYIWKQHNQCT FIWYNQWRALWFWHKYQWE*YFWK*TSTWDSWN WAWCRIWNSSWCWTGIFVWEQPT*DWRASWYRSL WGPWI*YYDSHFGLWSPPGPSSFDRSKCFCCPA GCSPAAHQ*SNILTFWRLSSLPESDVRP*EEGR EIETNKSSSPEGSYYTYSL*TDTPPCH*SPAKGF TNNRHSQVTSL*WAG*R*TIPSQWSIHAQEEH* EVGFEEP***QSLFSC*S*FRKSSFTI*ISRKW REI*FPKQTC**ESPAGWR*RFPCFTFLY*PYCQ TYSSNPRKCWK*TQQQQQCG*YHCCIKHACCFA KWAGRKQ*RNVFS**VTSG*PRRNRK*FLPYAP SRYYSH*GWLLYYSIYG*PC*NYQ*KRRVHCL*F HYWSERLWFNLF*RRCEFDKSKFG*YCAYPEER SSCLLR**PKTTCG*RAK*EG*SYIGWSLANR* NISLFNKEPRSPC*YQL*RKIGSSFKETGSSIQR IPA*NWFLGV*GLPFF*VWPSGF**RGGGASV* N*YKEVEDCSFASCKPDYALADGS*WQTCTSTS EPEPRGGAVREGCGTGQ*HGRYHPGASFGYHVRR EHA*GSGTCVCLNTYCIFTGN*STCLTDHESII AY**RRCRYGTGSTLQSPAFQSRYFSRNLFSQT PHFSIPLVENSFTSWWVTTIKIYKWSFSFTKCLC ARMSYSQSSIFNEYPIHILLVCPSTPDFCVHNA QPSP*GSVENSGYT*ATRPSPS*KVCHLWQGKT LDGHGPIHGTLISCWLGPQLDSC**WRTAEWLS* TRKSSDCRFHGVWIPAQSSSC*TPN*VPIQSSL RKTQFETKKAR*RHEIISDTSGAQIKTQHCPCG *TVSSHCPQSGSCCHS*LCRLG*RSIRRLTRSTN CEALEPDMDTM*SPMGPPEGA*QPAK*TP*IHS NSGAKKSFLPLAILYCHTSD*RGSLLNPKKQPC GGCIQLPHRQKDQ*GLLSGPAVRGSSSCSSFISV CG*PVSPGAAHHAVGGLASAPSRLLHPG*ETAH LCSVGWKTGVAALRKEANKRVLPVGLETLPGYP SLVFASTNSLHF*GAQHV*RSISEYL*Q*QICLL PTSFVSGGFWLCDSGGAKLTDTTSRCLLSPSKT LQ*QHT*EGCSRAAYPALPAVGDP*ILG*RDFP YPEAPCTCQMDPRGQSCASTHGI*QALRGPLLI* G*ALEPLPQAHHPTLSF*CHH**EL*LPEGVLG RPGTSRAQQPNSGLGNIWACLPGLY*SH*NAPP YTAGGLLR**PGAVTHQSDFTVQSDRADSVLQC* RSPGSVRHGQTCSQPAARGAESASSS**NLRLN TRPSASPFAPLGSPHWPASHA*GLCHGRTAQPY PVLSARTGCWEPVSPRHFASQSHAHSHHTEVPCL VWIGTVCHSLGWLWHLPSLPAARSSILHLFRAF LNTERSIRASGTQKRRQFTILKIIQCFSFKKMV NKAPLAESPKEPGYSFSIPSHSGSCDPPCQPASL LLPWPFYTRTP*EE*DR**WILNR*TIHRRKRD PSLK*LVS*H*ILEAKEGWPELGNKMGSF*HT* GRSECLSRRD*SSGLFLFLPLEFHEHHTFATTMC RNPWSHVTCLWEAPRVWFGPWFSVLLRLCLDLP AEFG*KMAGWVTLPVHPMLAPKHFPPSIYPFQK QKQTMTEAGMELGVRGRQRAFATLLTAIGSPR*W HEIAGVRAISGNMATPGSLCMKIM*RFLLKNIY MYK*MI*IFSSFSEATFLKNK*NVYSIPG

Frame 1

PAAPADRGKERVE*LPCHSGAVPLIGPSSLSPS RGAPRKGAESLCCVTTLPDTPPVLPNLAIHKPT SRGPV*RHDTLPPTAAARGGTPRPSHRSYPVPPR TPSAPPLPSRPFPLQFGFKRRVAQ*ITGSTQSG GRVHQFADGEGGASATSL*RRAACDAVGPSARC ARSGGRWQGW*RRRRRFRGGRALLCERRVAAGDS *HFPFPTEPRFLKQRLILKMFNKSFGTPFGGGT GGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNN TGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGF GTSTGTANTLFGTASTGTSLFSSQNNAFAQNKP TGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSL FGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTN ISTKHQCITAMKEYESKSLEELRLEDYQANRKG PQNQVGAGTTTGLFGSSPATSSATGLFSSSTTN SGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQT TSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTN TMGLFGVTQASQPGGLFGTATNTSTGTAFGTGT GLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAP SFGTTSGGLFGFGTNTSGNSIFGSKPAPGTLGT GLGAGFGTALGAGQASLFGNNQPKIGGPLGTGA FGAPGFNTTTATLGFGAPQAPVALTDPNASAAQQ AVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEE RLKPTNPAAQKALTTPTHYKLTPRPATRVRPKA LQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIK KLVLKNLNNSNLFSPVNRDSENLASPSEYPENG ERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIA KPIPQTPESAGNKHSNSNSVDDTIVALNMRAALR NGLEGSSEETSFHDESLQDDREEIENNSYHMHP AGIILTKVGYYTIPSMDDLAKITNEKGECIVSD FTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKE VVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDK TSRCLIKSPDRLADINYEGRLEAVSRKQGAQFK EYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSK TSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLE ESMPEDQEPVSASTHIASSLGINPHVLQIMKASL LTDEEDVDMALDQRFSRLPSKADTSQEICSPRL PISASHSSKTRSLVGGLLQSKFTSGAFLSPSVS VQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMP SPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKL LMDMALFMGRSFRVGWGPNWTLANSGEQLNGSH ELENHQIADSMEFGFLPNPVAVKPLTESPFKVHL EKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVD ELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQ IVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQ ILERRRAFSRWLSCTATPQIEEEVSLTQKNSPV EAVFSYLTGKRISEACSLAQQSGDHRLALLLSQ FVGSQSVRELLTMQLVDWHQLQADSFIQDERLRI FALLAGKPVWQLSEKKQINVCSQLDWKRSLAIH LWYLLPPTASISRALSMYEEAFQNTSDSDRYAC SPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKL YSDSIREKAVRELLTRHCQLLETPESWAKETFL TQKLRVPAKWIHEAKAVRAHMESDKHLEALCLF KAEHWNRCHKLIIRHLASDAIINENYDYLKGFLE DLAPPERSSLIQDWETSGLVYLDYIRVIEMLRH IQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSA KDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDST PDPQRVPLRLLAPHIGRLPMPEDYAMDELRSLT QSYLRELAVGSL*APGTLHHSHMPIHTTQRFPA LFGLALFAILWVGCGIYPPSLLPEAASSTCSGLF LILNVA*GLLEPRRGDSLPSSRSFSVFPLKKWS IKLLWQNPPKNQGILFPSLAILDLVTLHANQLP YSYPGPFILGLLRRSETGDNGSLTDELSTEGRGI RLLSNWLVNTEFWRQRRVGLS*ETKWDLSDTLR AEVNACHGGIDLQGCFCSCL*SSMNTIPLLLLC AGTLGHM*HVCGKLPEFGLVPGFQSC*DSVWICL QSLDKKWQVG*PSLFIPC*LQSISHPPSTPSRS KNKP*LRQAWSWALGAGRGPLLHC*QL*GAPGN GMR*LVLGLSQAIWPHLGLYA*R*CKGFY*KIYI CINK*SRYFPLFLKLLS*KINKMFIAFLV

Frame 2

QQRRRTGARKGSNSYHAILGPSL*LARAPSARV AALQGRGRSLYVASPPFPTPRRCFPI*PFTSPL REALCDVTTRSRQPRRRGAGLHGPLTAPTLCLP ELLLPLLFPLAPSPFSSVSKDALPNE*QGRPRVA AASTNSRTARAERPQRASDAGRRVTQSGPLRAA PEAAVGGRGGSGGGDGFVGAARCSVSGGWQQGT PDTSPSPPNRAF*NKDSF*RCLTNHLEHPLGVAQ VALAQLQHLDRILALALLVEGHLEHLHLVLATI LEASLEIHRLNQEDCLEPVHLASQLPPQALALG LVRQQEQQIPCLELQAQGPVSSHPKTMPLHKINQ LALAILEPVLAVEDSLEPQIPPLILLAAHLAPS LGQVVLQLLLLGLLLNLTLQLVQILWSKLELAL T*VPSTSVLLL*KNMKASH*RNFV*RIIRLTGRA HRTRWEQVPQLACLGLLQPLPAQQDSSAPPPLI QALHMVRTKLPLELVQLDLEQIQVVSLANRISR LPASSANHLARLQPPRTLAFPLVIPAP*DSQAPT PWDYLE*PKPHSLEVFLGQLQTPALGQHLEQEQ VSLGRPILDLVLLVRPCLAITSLLHLEAAQPVH LHLVQPVAGSLVLAQIPVGIVFLEVNQHLGLLEL GLVQDLEQLLVLDRHLCLGTTNLRLEGLLVQEP LGPLDLILRQPLWALEPPRPQ*L*QIQMLLLPS RLFSSSTSIV*HTHLLETLLSSGIRCQTLRRRKR D*NQQIQQPRRLLLHLLIIN*HPALPLESGQRL YKQQAQPSHISLMGWMTMNHP*PMEHSCPRRAL RSWF*RTLIIAISFLLLIVIQKI*LHHLNIQKME RDLVS*ANLLMRITSRMEMKIPLFHIFILTLLP NLFLKPQKVLEINTATATVWMIPLLH*TCVLLC EMGWKEAVKKRLFMMSHFRMTEKK*KIILTICTQ QVLFSLRLVTILFHLWMTLLKLPMKKESALSLI SLLVGKVMVQSILKEM*I*QI*IWMILCISGGK K*LST*MITKNHLWVKG*IGRLKLHWMEFGQQIK HLVV**RAQIALLISTMKEDWKQFQGNRELNSK NTGLKLVLGCLRSPIFLSMAFRILMKRRRSIRL KLVQRS*RLLLCLLQARLRPCRWLLMANLHLHLR ARAQRWSS*GGLWNWTVTW*ISPRSQFWIPC*K RACLRIRNLCLPQHILHLHWELIHMSYRS*KHH CLLMKKM*IWHWINASVACLPKQILLKKSVLPDS PFQHPTRRKLVH*LVGYYNQNLQVELFFHQVSL CKNVVLPEQHL**ISHPHPLGLSLHP*LLCSQC PAQPLRFR*KQWVHVGN*A*SLVKSLSPMARENS *WTWPYSWDAHFVLVGAPTGLLLIVENS*MALM N*KIIRLPIPWSLDSCPIQ*LLNP*LSPHSKFT *KNSV*DKESQMKT*NYIRHLWSSN*NTALSMWM NCVLSLSPIWELLSFMTMQIGLKKHQETYQKHK L*STGA*HGHYVKPYGAT*RSLTAS*MNPVNTF KFWSEEELSPAGYPVLPHLRLKRKSP*PKKTALW RLYSATSQAKGSVRPALWPSSQGIIVLLFFYLS LWVASQSGSCSPCSWWTGISSKQTPSSRMRDCA SLLCWLENRCGSSQKRSK*TCAPSWIGNAPWLSI FGICFHQQPPFLGRSACMKKHFRIPLTVTDMPA PHFLRIWRVLAV**RRSKTHRHHFEMSAFTF*N STVTAYVRRLFESCLPGTASCWRPLNLGLKRLSL PRSSVYLPNGSTRPKLCEHTWNLTST*RPFAYL RLSTGTAATSSSSDT*LLMPSLMRTMTT*RGSW KTWHLQSAAA*FRIGKHLGLFTWTILESLKCSAI YSRWIAQVMTWSSYTSK*LHCAVG*SRFSVTVL KIAWLSQTWPNV*PTCCAWC*VCIILLIEPPTQ HQTLSESLCASWLPTLAGFPCLRTMPWTNCAALP SPICENWLLGACEPQALCITVTCPFTPHRGSLP CLDWHCLPFSGLAVASTLPPCCQKQHPPLVQGF S*Y*T*HKGFWNPEEETVYHPQDHSVFFL*KNGQ *SSFGRIPQRTRVFFFHP*PFWIL*PSMPTSFP TPTLALLY*DSLGGVRQVIMDP*QMNYPQKEEG SVS*VIG*LTLNFGGKGGLA*VRKQNGIFLTHLG QK*MPVTEGLIFRAVFVPAFRVP*TPYLCYYYV QEPLVTCDMSVGSSQSLVWSLVFSLAETLSGFA CRVWIKNGRLGNPPCSSHVSSKAFPTLHLPLPEA KTNHD*GRHGVGR*GQAEGLCYTADSYREPQVM A*DSWC*GYLRQYGHTWVFMHEDNVKVFIKKYI YV*INDLDIFLFF*SYFLKK*IKCL*HSW

Sequence NUP98.fAug05

CCCAATCCAGTAGCTGTTAAACCTTGTGAAGCACTGGAGCCTGACATGGACACTATGTGAAGCCCTATGGGGCCACCTGAAGGAGCTTGACAGCCAGCTA AATGAACCCCGTGAATACATTCAAATTCTGGAGCGAAGAAGAGCTTTCTCCCGCTGGCTATCCTGTACTGCCACACCTCAGATTGAAGAGGAAGTCTCCT TAACCCAAAAAAACAGCCCTGTGGAGGCTGTATTCAGCTACCTCACAGGCAAAAGGATCAGTGAGGCCTGCTCTCTGGCCCAGCAGTCAGGGGATCATCG TCTTGCTCTTCTTTTATCTCAGTTTGTGGGTAGCCAGTCAGTCCGGGAGCTGCTCACCATGCAGTTGGTGGACTGGCATCAGCTCCAAGCAGACTCCTTC ATCCAGGATGAGAGACTGCGCATCTTTGCTCTGTTGGCTGGAAAACCGGTGTGGCAGCTCTCAGAAAAGAAGCAAATAAACGTGTGCTCCCAGTTGGATT GGAAACGCTCCCTGGCTATCCATCTTTGGTATTTGCTTCCACCAACAGCCTCCATTTCTAGGGCGCTCAGCATGTATGAAGAAGCATTTCAGAATACCTC TGACAGTGACAGATATGCCTGCTCCCCACTTCCTTCGTATCTGGAGGGTTCTGGCTGTGTGATAGCGGAGGAGCAAAACTCACAGACACCACTTCGAGAT GTCTGCTTTCACCTTCTAAAACTCTACAGTGACAGACATTATGATCTCAACCAGCTGCTGGAGCCTCGAAGCATAACAGCAGATCCTTTGGACTACCGCC TAAGCTGGCACTTGTGGGAAGTGCTGAGGGCTCTTAACTACACCCATCTCTCAGCGCAGTGTGAAGCATACGTGAGAAGGCTGTTCGAGAGCTGCTTACC CGGCACTGCCAGCTGTTGGAGACCCCTGAATCTTGGGCTAAAGAGACTTTCCTTACCCAGAAGCTCCGTGTACCTGCCAAATGGATCCACGAGGCCAAAG CTGTGCGAGCACACATGGAATCTGACAAGCACTTAGAGGCCCTTTGCTTATTTAAGGCTGAGCACTGGAACCGCTGCCACAAGCTCATCATCCGACACTT AGCTTCTGATGCCATCATTAATGAGAACTATGACTACCTGAAGGGGTTCTTGGAAGACCTGGCACCTCCAGAGCGCAGC

NUP98.F1 (forward primer)
NUP98.R1 (reverse primer)
Single exon skipping

Frame 0

PNPVAVKPCEALEPDMDTM*SPMGPPEGA*QPA K*TP*IHSNSGAKKSFLPLAILYCHTSD*RGSLL NPKKQPCGGCIQLPHRQKDQ*GLLSGPAVRGSS SCSSFISVCG*PVSPGAAHHAVGGLASAPSRLL HPG*ETAHLCSVGWKTGVAALRKEANKRVLPVGL ETLPGYPSLVFASTNSLHF*GAQHV*RSISEYL *Q*QICLLPTSFVSGGFWLCDSGGAKLTDTTSR CLLSPSKTLQ*QTL*SQPAAGASKHNSRSFGLPP KLALVGSAEGS*LHPSLSAV*SIREKAVRELLT RHCQLLETPESWAKETFLTQKLRVPAKWIHEAK AVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHL ASDAIINENYDYLKGFLEDLAPPERS

Frame 1

PIQ*LLNLVKHWSLTWTLCEALWGHLKELDSQL NEPREYIQILERRRAFSRWLSCTATPQIEEEVS LTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHR LALLLSQFVGSQSVRELLTMQLVDWHQLQADSF IQDERLRIFALLAGKPVWQLSEKKQINVCSQLD WKRSLAIHLWYLLPPTASISRALSMYEEAFQNTS DSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRD VCFHLLKLYSDRHYDLNQLLEPRSITADPLDYR LSWHLWEVLRALNYTHLSAQCEAYVRRLFESCLP GTASCWRPLNLGLKRLSLPRSSVYLPNGSTRPK LCEHTWNLTST*RPFAYLRLSTGTAATSSSSDT *LLMPSLMRTMTT*RGSWKTWHLQSA

Frame 2

QSSSC*TL*STGA*HGHYVKPYGAT*RSLTAS* MNPVNTFKFWSEEELSPAGYPVLPHLRLKRKSP *PKKTALWRLYSATSQAKGSVRPALWPSSQGII VLLFFYLSLWVASQSGSCSPCSWWTGISSKQTPS SRMRDCASLLCWLENRCGSSQKRSK*TCAPSWI GNAPWLSIFGICFHQQPPFLGRSACMKKHFRIP LTVTDMPAPHFLRIWRVLAV**RRSKTHRHHFEM SAFTF*NSTVTDIMISTSCWSLEA*QQILWTTA *AGTCGKC*GLLTTPISQRSVKHT*EGCSRAAY PALPAVGDP*ILG*RDFPYPEAPCTCQMDPRGQS CASTHGI*QALRGPLLI*G*ALEPLPQAHHPTL SF*CHH**EL*LPEGVLGRPGTSRAQ