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Sequences

Sequence MCL1.bAug05

CCGGCCCCGGCCCCGGCCCCGGCCCCGCCCCGGCCCGGCCGGGCAGCTGGTAGGTGCCGTGCGCAACCCTCCGGAAGCTGCCGCCCCTTTCCCCTTTTAT GGGAATACTTTTTTTAAAAAAAAAGAGTTCGCTGGCGCCACCCCGTAGGACTGGCCGCCCTAAAACCGTGATAAAGGAGCTGCTCGCCACTTCTCACTTC CGCTTCCTTCCAGTAAGGAGTCGGGGTCTTCCCCAGTTTTCTCAGCCAGGCGGCGGCGGCGACTGGCAATGTTTGGCCTCAAAAGAAACGCGGTAATCGG ACTCAACCTCTACTGTGGGGGGGCCGGCTTGGGGGCCGGCAGCGGCGGCGCCACCCGCCCGGGAGGGCGACTTTTGGCTACGGAGAAGGAGGCCTCGGCC CGGCGAGAGATAGGGGGAGGGGAGGCCGGCGCGGTGATTGGCGGAAGCGCCGGCGCAAGCCCCCCGTCCACCCTCACGCCAGACTCCCGGAGGGTCGCGC GGCCGCCGCCCATTGGCGCCGAGGTCCCCGACGTCACCGCGACCCCCGCGAGGCTGCTTTTCTTCGCGCCCACCCGCCGCGCGGCGCCGCTTGAGGAGAT GGAAGCCCCGGCCGCTGACGCCATCATGTCGCCCGAAGAGGAGCTGGACGGGTACGAGCCGGAGCCTCTCGGGAAGCGGCCGGCTGTCCTGCCGCTGCTG GAGTTGGTCGGGGAATCTGGTAATAACACCAGTACGGACGGGTCACTACCCTCGACGCCGCCGCCAGCAGAGGAGGAGGAGGACGAGTTGTACCGGCAGT CGCTGGAGATTATCTCTCGGTACCTTCGGGAGCAGGCCACCGGCGCCAAGGACACAAAGCCAATGGGCAGGTCTGGGGCCACCAGCAGGAAGGCGCTGGA GACCTTACGACGGGTTGGGGATGGCGTGCAGCGCAACCACGAGACGGCCTTCCAAGGATGGGTTTGTGGAGTTCTTCCATGTAGAGGACCTAGAAGGTGG CATCAGGAATGTGCTGCTGGCTTTTGCAGGTGTTGCTGGAGTAGGAGCTGGTTTGGCATATCTAATAAGATAGCCTTACTGTAAGTGCAATAGTTGACTT TTAACCAACCACCACCACCACCAAAACCAGTTTATGCAGTTGGACTCCAAGCTGTAACTTCCTAGAGTTGCACCCTAGCAACCTAGCCAGAAAAGCAAGT GGCAAGAGGATTATGGCTAACAAGAATAAATACATGGGAAGAGTGCTCCCCATTGATTGAAGAGTCACTGTCTGAAAGAAGCAAAGTTCAGTTTCAGCAA CAAACAAACTTTGTTTGGGAAGCTATGGAGGAGGACTTTTAGATTTAGTGAAGATGGTAGGGTGGAAAGACTTAATTTCCTTGTTGAGAACAGGAAAGTG GCCAGTAGCCAGGCAAGTCATAGAATTGATTACCCGCCGAATTCATTAATTTACTGTAGTGTTAAGAGAAGCACTAAGAATGCCAGTGACCTGTGTAAAA GTTACAAGTAATAGAACTATGACTGTAAGCCTCAGTACTGTACAAGGGAAGCTTTTCCTCTCTCTAATTAGCTTTCCCAGTATACTTCTTAGAAAGTCCA AGTGTTCAGGACTTTTATACCTGTTATACTTTGGCTTGGTTTCCATGATTCTTACTTTATTAGCCTAGTTTATCACCAATAATACTTGACGGAAGGCTCA GTAATTAGTTATGAATATGGATATCCTCAATTCTTAAGACAGCTTGTAAATGTATTTGTAAAAATTGTATATATTTTTACAGAAAGTCTATTTCTTTGAA ACGAAGGAAGTATCGAATTTACATTAGTTTTTTTCATACCCTTTTGAACTTTGCAACTTCCGTAATTAGGAACCTGTTTCTTACAGCTTTTCTATGCTAA ACTTTGTTCTGTTCAGTTCTAGAGTGTATACAGAACGAATTGATGTGTAACTGTATGCAGACTGGTTGTAGTGGAACAAATCTGATAACTATGCAGGTTT AAATTTTCTTATCTGATTTTGGTAAGTATTCCTTAGGTTTTTCTTTGAAAACCTGGGATTGAGAGGTTGATGAATGGAAATTCTTTCACTTCATTATATG CAAGTTTTCAATAATTAGGTCTAAGTGGAGTTTTAAGGTTACTGATGACTTACAAATAATGGGCTCTGATTGGGCAATACTCATTTGAGTTCCTTCCATT TGACCTAATTTAACTGGTGAAATTTAAAGTGAATTCATGGGCTCATCTTTAAAGCTTTTACTAAAAGATTTTCAGCTGAATGGAACTCATTAGCTGTGTG CATATAAAAAGATCACATCAGGTGGATGGAGAGACATTTGATCCCTTGTTTGCTTAATAAATTATAAAATGATGGCTTGGAAAAGCAGGCTAGTCTAACC ATGGTGCTATTATTAGGCTTGCTTGTTACACACACAGGTCTAAGCCTAGTATGTCAATAAAGCAAATACTTACTGTTTTGTTTCTATTAATGATTCCCAA ACCTTGTTGCAAGTTTTTGCATTGGCATCTTTGGATTTCAGTCTTGATGTTTGTTCTATCAGACTTAACCTTTTATTTCCTGTCCTTCCTTGAAATTGCT GATTGTTCTGCTCCCTCTACAGATATTTATATCAATTCCTACAGCTTTCCCCTGCCATCCCTGAACTCTTTCTAGCCCTTTTAGATTTTGGCACTGTGAA ACCCCTGCTGGAAACCTGAGTGACCCTCCCTCCCCACCAAGAGTCCACAGACCTTTCATCTTTCACGAACTTGATCCTGTTAGCAGGTGGTAATACCATG GGTGCTGTGACACTAACAGTCATTGAGAGGTGGGAGGAAGTCCCTTTTCCTTGGACTGGTATCTTTTCAACTATTGTTTTATCCTGTCTTTGGGGGCAAT GTGTCAAAAGTCCCCTCAGGAATTTTCAGAGGAAAGAACATTTTATGAGGCTTTCTCTAAAGTTTCCTTTGTATAGGAGTATGCTCACTTAAATTTACAG AAAGAGGTGAGCTGTGTTAAACCTCAGAGTTTAAAAGCTACTGATAAACTGAAGAAAGTGTCTATATTGGAACTAGGGTCATTTGAAAGCTTCAGTCTCG GAACATGACCTTTAGTCTGTGGACTCCATTTAAAAATAGGTATGAATAAGATGACTAAGAATGTAATGGGGAAGAACTGCCCTGCCTGCCCATCTCAGAG CCATAAGGTCATCTTTGCTAGAGCTATTTTTACCTATGTATTTATCGTTCTTGATCATAAGCCGCTTATTTATATCATGTATCTCTAAGGACCTAAAAGC ACTTTATGTAGTTTTTAATTAATCTTAAGATCTGGTTACGGTAACTAAAAAAGCCTGTCTGCCAAATCCAGTGGAAACAAGTGCATAGATGTGAATTGGT TTTTAGGGGCCCCACTTCCCAATTCATTAGGTATGACTGTGGAAATACAGACAAGGATCTTAGTTGATATTTTGGGCTTGGGGCAGTGAGGGCTTAGGAC ACCCCAAGTGGTTTGGGAAAGGAGGAGGGGAGTGGTGGGTTTATAGGGGGAGGAGGAGGCAGGTGGTCTAAGTGCTGACTGGCTACGTAGTTCGGGCAAA TCCTCCAAAAGGGAAAGGGAGGATTTGCTTAGAAGGATGGCGCTCCCAGTGACTACTTTTTGACTTCTGTTTGTCTTACGCTTCTCTCAGGGAAAAACAT GCAGTCCTCTAGTGTTTCATGTACATTCTGTGGGGGGTGAACACCTTGGTTCTGGTTAAACAGCTGTACTTTTGATAGCTGTGCCAGGAAGGGTTAGGAC CAACTACAAATTAATGTTGGTTGTCAAATGTAGTGTGTTTCCCTAACTTTCTGTTTTTCCTGAGAAAAAAAAATAAATCTTTTATTCAAATACAGGGTG

MCL1.F1 (forward primer)
MCL1.R1 (reverse primer)
Alternative donor

Frame 0

PAPAPAPAPPRPGRAAGRCRAQPSGSCRPFPLL WEYFF*KKRVRWRHPVGLAALKP**RSCSPLLTS ASFQ*GVGVFPSFLSQAAAATGNVWPQKKRGNR TQPLLWGGRLGGRQRRRHPPGRATFGYGEGGLG PARDRGRGGRRGDWRKRRRKPPVHPHARLPEGRA AAAHWRRGPRRHRDPREAAFLRAHPPRGAA*GD GSPGR*RHHVARRGAGRVRAGASREAAGCPAAA GVGRGIW**HQYGRVTTLDAAASRGGGGRVVPAV AGDYLSVPSGAGHRRQGHKANGQVWGHQQEGAG DLTTGWGWRAAQPRDGLPRMGLWSSSM*RT*KV ASGMCCWLLQVLLE*ELVWHI**DSLTVSAIVDF *PTTTTTKTSLCSWTPSCNFLELHPSNLARKAS GKRIMANKNKYMGRVLPID*RVTV*KKQSSVSA TNKLCLGSYGGGLLDLVKMVGWKDLISLLRTGKW PVARQVIELITRRIH*FTVVLREALRMPVTCVK VTSNRTMTVSLSTVQGKLFLSLISFPSILLRKS KCSGLLYLLYFGLVSMILTLLA*FITNNT*RKAQ *LVMNMDILNS*DSL*MYL*KLYIFLQKVYFFE TKEVSNLH*FFSYPFELCNFRN*EPVSYSFSML NFVLFSSRVYTERIDV*LYADWL*WNKSDNYAGL NFLI*FW*VFLRFFFENLGLRG**MEILSLHYM QVFNN*V*VEF*GY**LTNNGL*LGNTHLSSFH LT*FNW*NLK*IHGLIFKAFTKRFSAEWNSLAVC I*KDHIRWMERHLIPCLLNKL*NDGLEKQASLT MVLLLGLLVTHTGLSLVCQ*SKYLLFCFY**FP NLVASFCIGIFGFQS*CLFYQT*PFISCPSLKLL IVLLPLQIFISIPTAFPCHP*TLSSPFRFWHCE TPAGNLSDPPSPPRVHRPFIFHELDPVSRW*YH GCCDTNSH*EVGGSPFSLDWYLFNYCFILSLGAM CQKSPQEFSEERTFYEAFSKVSFV*EYAHLNLQ KEVSCVKPQSLKATDKLKKVSILELGSFESFSL GT*PLVCGLHLKIGMNKMTKNVMGKNCPACPSQS HKVIFARAIFTYVFIVLDHKPLIYIMYL*GPKS TLCSF*LILRSGYGN*KSLSAKSSGNKCIDVNW FLGAPLPNSLGMTVEIQTRILVDILGLGQ*GLRT PQVVWERRRGVVGL*GEEEAGGLSADWLRSSGK SSKREREDLLRRMALPVTTF*LLFVLRFSQGKT CSPLVFHVHSVGGEHLGSG*TAVLLIAVPGRVRT NYKLMLVVKCSVFP*LSVFPEKKK*IFYSNTG

Frame 1

RPRPRPRPRPGPAGQLVGAVRNPPEAAAPFPFY GNTFFKKKEFAGATP*DWPP*NRDKGAARHFSL PLPSSKESGSSPVFSARRRRRLAMFGLKRNAVIG LNLYCGGAGLGAGSGGATRPGGRLLATEKEASA RREIGGGEAGAVIGGSAGASPPSTLTPDSRRVA RPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEM EAPAADAIMSPEEELDGYEPEPLGKRPAVLPLL ELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQ SLEIISRYLREQATGAKDTKPMGRSGATSRKALE TLRRVGDGVQRNHETAFQGWVCGVLPCRGPRRW HQECAAGFCRCCWSRSWFGISNKIALL*VQ*LT FNQPPPPPKPVYAVGLQAVTS*SCTLAT*PEKQV ARGLWLTRINTWEECSPLIEESLSERSKVQFQQ QTNFVWEAMEEDF*I**RW*GGKT*FPC*EQES GQ*PGKS*N*LPAEFINLL*C*EKH*ECQ*PV*K LQVIEL*L*ASVLYKGSFSSL*LAFPVYFLESP SVQDFYTCYTLAWFP*FLLY*PSLSPIILDGRL SN*L*IWISSILKTACKCICKNCIYFYRKSISLK RRKYRIYISFFHTLLNFATSVIRNLFLTAFLC* TLFCSVLECIQNELMCNCMQTGCSGTNLITMQV *IFLSDFGKYSLGFSLKTWD*EVDEWKFFHFIIC KFSIIRSKWSFKVTDDLQIMGSDWAILI*VPSI *PNLTGEI*SEFMGSSLKLLLKDFQLNGTH*LC AYKKITSGGWRDI*SLVCLINYKMMAWKSRLV*P WCYY*ACLLHTQV*A*YVNKANTYCFVSINDSQ TLLQVFALASLDFSLDVCSIRLNLLFPVLP*NC *LFCSLYRYLYQFLQLSPAIPELFLALLDFGTVK PLLET*VTLPPHQESTDLSSFTNLILLAGGNTM GAVTLTVIERWEEVPFPWTGIFSTIVLSCLWGQ CVKSPLRNFQRKEHFMRLSLKFPLYRSMLT*IYR KR*AVLNLRV*KLLIN*RKCLYWN*GHLKASVS EHDL*SVDSI*K*V*IR*LRM*WGRTALPAHLR AIRSSLLELFLPMYLSFLIISRLFISCISKDLKA LYVVFN*S*DLVTVTKKACLPNPVETSA*M*IG F*GPHFPIH*V*LWKYRQGS*LIFWAWGSEGLG HPKWFGKGGGEWWVYRGRRRQVV*VLTGYVVRAN PPKGKGRICLEGWRSQ*LLFDFCLSYASLREKH AVL*CFMYILWGVNTLVLVKQLYF**LCQEGLG PTTN*CWLSNVVCFPNFLFFLRKKNKSFIQIQG

Frame 2

GPGPGPGPAPARPGSW*VPCATLRKLPPLSPFM GILFLKKKSSLAPPRRTGRPKTVIKELLATSHF RFLPVRSRGLPQFSQPGGGGDWQCLASKETR*S DSTSTVGGPAWGPAAAAPPAREGDFWLRRRRPRP GER*GEGRPAR*LAEAPAQAPRPPSRQTPGGSR GRRPLAPRSPTSPRPPRGCFSSRPPAARRRLRR WKPRPLTPSCRPKRSWTGTSRSLSGSGRLSCRCW SWSGNLVITPVRTGHYPRRRRQQRRRRTSCTGS RWRLSLGTFGSRPPAPRTQSQWAGLGPPAGRRW RPYDGLGMACSATTRRPSKDGFVEFFHVEDLEGG IRNVLLAFAGVAGVGAGLAYLIR*PYCKCNS*L LTNHHHHQNQFMQLDSKL*LPRVAP*QPSQKSK WQEDYG*QE*IHGKSAPH*LKSHCLKEAKFSFSN KQTLFGKLWRRTFRFSEDGRVERLNFLVENRKV ASSQASHRIDYPPNSLIYCSVKRSTKNASDLCK SYK**NYDCKPQYCTREAFPLSN*LSQYTS*KVQ VFRTFIPVILWLGFHDSYFISLVYHQ*YLTEGS VISYEYGYPQFLRQLVNVFVKIVYIFTESLFL* NEGSIEFTLVFFIPF*TLQLP*LGTCFLQLFYAK LCSVQF*SVYRTN*CVTVCRLVVVEQI**LCRF KFSYLILVSIP*VFL*KPGIERLMNGNSFTSLY ASFQ*LGLSGVLRLLMTYK*WALIGQYSFEFLPF DLI*LVKFKVNSWAHL*SFY*KIFS*MELISCV HIKRSHQVDGETFDPLFA**IIK*WLGKAG*SN HGAIIRLACYTHRSKPSMSIKQILTVLFLLMIPK PCCKFLHWHLWISVLMFVLSDLTFYFLSFLEIA DCSAPSTDIYINSYSFPLPSLNSF*PF*ILAL* NPCWKPE*PSLPTKSPQTFHLSRT*SC*QVVIPW VL*H*QSLRGGRKSLFLGLVSFQLLFYPVFGGN VSKVPSGIFRGKNIL*GFL*SFLCIGVCSLKFT ERGELC*TSEFKSY**TEESVYIGTRVI*KLQSR NMTFSLWTPFKNRYE*DD*ECNGEELPCLPISE P*GHLC*SYFYLCIYRS*S*AAYLYHVSLRT*K HFM*FLINLKIWLR*LKKPVCQIQWKQVHRCELV FRGPTSQFIRYDCGNTDKDLS*YFGLGAVRA*D TPSGLGKEEGSGGFIGGGGGRWSKC*LAT*FGQ ILQKGKGGFA*KDGAPSDYFLTSVCLTLLSGKNM QSSSVSCTFCGG*TPWFWLNSCTFDSCARKG*D QLQINVGCQM*CVSLTFCFS*EKKINLLFKYRV

Sequence MCL1.cAug05

CGCGCCCACCCGCCGCGCGGCGCCGCTTGAGGAGATGGAAGCCCCGGCCGCTGACGCCATCATGTCGCCCGAAGAGGAGCTGGACGGGTACGAGCCGGAG CCTCTCGGGAAGCGGCCGGCTGTCCTGCCGCTGCTGGAGTTGGTCGGGGAATCTGGTAATAACACCAGTACGGACGGGTCACTACCCTCGACGCCGCCGC CAGCAGAGGAGGAGGAGGACGAGTTGTACCGGCAGTCGCTGGAGATTATCTCTCGGTACCTTCGGGAGCAGGCCACCGGCGCCAAGGACACAAAGCCAAT GGGCAGGTCTGGGGCCACCAGCAGGAAGGCGCTGGAGACCTTACGACGGGTTGGGGATGGCGTGCAGCGCAACCACGAGACGGCCTTCCAAGGTAAGGGG GTTCATTAATCGCCAAGGCCTCACTCCCTTTTTTCCATCTCTCCCCGGACTCACCCGCCAAGGGTGGGTTGGAAACCGAAACGAGTCAGTGTTGAAACGT GTCTCATCCTATTCCTGAAGCCAGAATATTCTGGCCATGAGTCATTGTTTCCGCCCATCTTGATTCTTTTGGAAATGGCAGCTCTTGTTCAAAGACCGGA AAGGGTGGGATGTCAATTTCAAGTGGGGTCAACCTGAGTTCTGTAAATCCCAGTAGCGATTTTCCCGCCGCGGGTGGGCAGGCGAATCTTGCGCCGGTTT AGACAAAGGAGGCCGTGAGGACCTGCATGCTTTTCTTTCTCAGGCATGCTTCGGAAACTGGACATCAAAAACGAAGACGATGTGAAATCGTTGTCTCGAG TGATGATCCATGTTTTCAGCGACGGCGTAACAAACTGGGGCAGGATTGTGACTCTCATTTCTTTTGGTGCCTTTGTGGCTAAACACTTGAAGACCATAAA CCAAGAAAGCTGCATCGAACCATTAGCAGAAAGTATCACAGACGTTCTCGTAAGGACAAAACGGGACTGGCTAGTTAAACAAAGAGGCTGGGATGGGTTT GTGGAGTTCTTCCATGTAGAGGACCTAGAAGGTGGCATCAGGAATGTGCTGCTGGCTTTTGCAGGTGTTGCTGGAGTAGGAGCTGGTTTGGCATATCTAA TAAGATAGCCTTACTGTAAGTGCAATAGTTGACTTTTAACCAACCACCACCACCACCAAAACCAGTTTATGCAGTTGGACTCCAAGCTGTAACTTCCTAG AGTTGCACCCTAGCAACCTAGCCAGAAAAGCAAGTGGCAAGAGGATTATGGCTAACAAGAATAAATACATGGGAAGAGTGCTCCCCATTGATTGAAGAGT CACTGTCTGAAAGAAGCAAAGTTCAGTTTCAGCAACAAACAAACTTTGTTTGGGAAGCTATGGAGGAGGACTTTTAGATTTAGTGAAGATGGTAGGGTGG AAAGACTTAATTTCCTTGTTGAGAACAGGAAAGTGGCCAGTAGCCAGGCAAGTCATAGAATTGATTACCCGCCGAATTCATTAATTTACTGTAGTGTTAA GAGAAGCACTAAGAATGCCAGTGACCTGTGTAAAAGTTACAAGTAATAGAACTATGACTGTAAGCCTCAGTACTGTACAAGGGAAGCTTTTCCTCTCTCT AATTAGCTTTCCCAGTATACTTCTTAGAAAGTCCAAGTGTTCAGGACTTTTATACCTGTTATACTTTGGCTTGGTTTCCATGATTCTTACTTTATTAGCC TAGTTTATCACCAATAATACTTGACGGAAGGCTCAGTAATTAGTTATGAATATGGATATCCTCAATTCTTAAGACAGCTTGTAAATGTATTTGTAAAAAT TGTATATATTTTTACAGAAAGTCTATTTCTTTGAAACGAAGGAAGTATCGAATTTACATTAGTTTTTTTCATACCCTTTTGAACTTTGCAACTTCCGTAA TTAGGAACCTGTTTCTTACAGCTTTTCTATGCTAAACTTTGTTCTGTTCAGTTCTAGAGTGTATACAGAACGAATTGATGTGTAACTGTATGCAGACTGG TTGTAGTGGAACAAATCTGATAACTATGCAGGTTTAAATTTTCTTATCTGATTTTGGTAAGTATTCCTTAGGTTTTTCTTTGAAAACCTGGGATTGAGAG GTTGATGAATGGAAATTCTTTCACTTCATTATATGCAAGTTTTCAATAATTAGGTCTAAGTGGAGTTTTAAGGTTACTGATGACTTACAAATAATGGGCT CTGATTGGGCAATACTCATTTGAGTTCCTTCCATTTGACCTAATTTAACTGGTGAAATTTAAAGTGAATTCATGGGCTCATCTTTAAAGCTTTTACTAAA AGATTTTCAGCTGAATGGAACTCATTAGCTGTGTGCATATAAAAAGATCACATCAGGTGGATGGAGAGACATTTGATCCCTTGTTTGCTTAATAAATTAT AAAATGATGGCTTGGAAAAGCAGGCTAGTCTAACCATGGTGCTATTATTAGGCTTGCTTGTTACACACACAGGTCTAAGCCTAGTATGTCAATAAAGCAA ATACTTACTGTTTTGTTTCTATTAATGATTCCCAAACCTTGTTGCAAGTTTTTGCATTGGCATCTTTGGATTTCAGTCTTGATGTTTGTTCTATCAGACT TAACCTTTTATTTCCTGTCCTTCCTTGAAATTGCTGATTGTTCTGCTCCCTCTACAGATATTTATATCAATTCCTACAGCTTTCCCCTGCCATCCCTGAA CTCTTTCTAGCCCTTTTAGATTTTGGCACTGTGAAACCCCTGCTGGAAACCTGAGTGACCCTCCCTCCCCACCAAGAGTCCACAGACCTTTCATCTTTCA CGAACTTGATCCTGTTAGCAGGTGGTAATACCATGGGTGCTGTGACACTAACAGTCATTGAGAGGTGGGAGGAAGTCCCTTTTCCTTGGACTGGTATCTT TTCAACTATTGTTTTATCCTGTCTTTGGGGGCAATGTGTCAAAAGTCCCCTCAGGAATTTTCAGAGGAAAGAACATTTTATGAGGCTTTCTCTAAAGTTT CCTTTGTATAGGAGTATGCTCACTTAAATTTACAGAAAGAGGTGAGCTGTGTTAAACCTCAGAGTTTAAAAGCTACTGATAAACTGAAGAAAGTGTCTAT ATTGGAACTAGGGTCATTTGAAAGCTTCAGTCTCGGAACATGACCTTTAGTCTGTGGACTCCATTTAAAAATAGGTATGAATAAGATGACTAAGAATGTA ATGGGGAAGAACTGCCCTGCCTGCCCATCTCAGAGCCATAAGGTCATCTTTGCTAGAGCTATTTTTACCTATGTATTTATCGTTCTTGATCATAAGCCGC TTATTTATATCATGTATCTCTAAGGACCTAAAAGCACTTTATGTAGTTTTTAATTAATCTTAAGATCTGGTTACGGTAACTAAAAAAGCCTGTCTGCCAA ATCCAGTGGAAACAAGTGCATAGATGTGAATTGGTTTTTAGGGGCCCCACTTCCCAATTCATTAGGTATGACTGTGGAAATACAGACAAGGATCTTAGTT GATATTTTGGGCTTGGGGCAGTGAGGGCTTAGGACACCCCAAGTGGTTTGGGAAAGGAGGAGGGGAGTGGTGGGTTTATAGGGGGAGGAGGAGGCAGGTG GTCTAAGTGCTGACTGGCTACGTAGTTCGGGCAAATCCTCCAAAAGGGAAAGGGAGGATTTGCTTAGAAGGATGGCGCTCCCAGTGACTACTTTTTGACT TCTGTTTGTCTTACGCTTCTCTCAGGGAAAAACATGCAGTCCTCTAGTGTTTCATGTACATTCTGTGGGGGGTGAACACCTTGGTTCTGGTTAAACAGCT GTACTTTTGATAGCTGTGCCAGGAAGGGTTAGGACCAACTACAAATTAATGTTGGTTGTCAAATGTAGTGTGTTTCCCTAACTTTCTGTTTTTCCTGAGA AAAAAAAATAAATCTTTTATTCAAATACAGGGTG

MCL1.F1 (forward primer)
MCL1.R1 (reverse primer)
Alternative donor

Frame 0

RAHPPRGAA*GDGSPGR*RHHVARRGAGRVRAG ASREAAGCPAAAGVGRGIW**HQYGRVTTLDAAA SRGGGGRVVPAVAGDYLSVPSGAGHRRQGHKAN GQVWGHQQEGAGDLTTGWGWRAAQPRDGLPR*G GSLIAKASLPFFHLSPDSPAKGGLETETSQC*NV SHPIPEARIFWP*VIVSAHLDSFGNGSSCSKTG KGGMSISSGVNLSSVNPSSDFPAAGGQANLAPV *TKEAVRTCMLFFLRHASETGHQKRRRCEIVVSS DDPCFQRRRNKLGQDCDSHFFWCLCG*TLEDHK PRKLHRTISRKYHRRSRKDKTGLAS*TKRLGWV CGVLPCRGPRRWHQECAAGFCRCCWSRSWFGISN KIALL*VQ*LTFNQPPPPPKPVYAVGLQAVTS* SCTLAT*PEKQVARGLWLTRINTWEECSPLIEE SLSERSKVQFQQQTNFVWEAMEEDF*I**RW*GG KT*FPC*EQESGQ*PGKS*N*LPAEFINLL*C* EKH*ECQ*PV*KLQVIEL*L*ASVLYKGSFSSL *LAFPVYFLESPSVQDFYTCYTLAWFP*FLLY*P SLSPIILDGRLSN*L*IWISSILKTACKCICKN CIYFYRKSISLKRRKYRIYISFFHTLLNFATSV IRNLFLTAFLC*TLFCSVLECIQNELMCNCMQTG CSGTNLITMQV*IFLSDFGKYSLGFSLKTWD*E VDEWKFFHFIICKFSIIRSKWSFKVTDDLQIMG SDWAILI*VPSI*PNLTGEI*SEFMGSSLKLLLK DFQLNGTH*LCAYKKITSGGWRDI*SLVCLINY KMMAWKSRLV*PWCYY*ACLLHTQV*A*YVNKA NTYCFVSINDSQTLLQVFALASLDFSLDVCSIRL NLLFPVLP*NC*LFCSLYRYLYQFLQLSPAIPE LFLALLDFGTVKPLLET*VTLPPHQESTDLSSF TNLILLAGGNTMGAVTLTVIERWEEVPFPWTGIF STIVLSCLWGQCVKSPLRNFQRKEHFMRLSLKF PLYRSMLT*IYRKR*AVLNLRV*KLLIN*RKCL YWN*GHLKASVSEHDL*SVDSI*K*V*IR*LRM* WGRTALPAHLRAIRSSLLELFLPMYLSFLIISR LFISCISKDLKALYVVFN*S*DLVTVTKKACLP NPVETSA*M*IGF*GPHFPIH*V*LWKYRQGS*L IFWAWGSEGLGHPKWFGKGGGEWWVYRGRRRQV V*VLTGYVVRANPPKGKGRICLEGWRSQ*LLFD FCLSYASLREKHAVL*CFMYILWGVNTLVLVKQL YF**LCQEGLGPTTN*CWLSNVVCFPNFLFFLR KKNKSFIQIQG

Frame 1

APTRRAAPLEEMEAPAADAIMSPEEELDGYEPE PLGKRPAVLPLLELVGESGNNTSTDGSLPSTPP PAEEEEDELYRQSLEIISRYLREQATGAKDTKPM GRSGATSRKALETLRRVGDGVQRNHETAFQGKG VH*SPRPHSLFSISPRTHPPRVGWKPKRVSVET CLILFLKPEYSGHESLFPPILILLEMAALVQRPE RVGCQFQVGST*VL*IPVAIFPPRVGRRILRRF RQRRP*GPACFSFSGMLRKLDIKNEDDVKSLSR VMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTIN QESCIEPLAESITDVLVRTKRDWLVKQRGWDGF VEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYL IR*PYCKCNS*LLTNHHHHQNQFMQLDSKL*LPR VAP*QPSQKSKWQEDYG*QE*IHGKSAPH*LKS HCLKEAKFSFSNKQTLFGKLWRRTFRFSEDGRV ERLNFLVENRKVASSQASHRIDYPPNSLIYCSVK RSTKNASDLCKSYK**NYDCKPQYCTREAFPLS N*LSQYTS*KVQVFRTFIPVILWLGFHDSYFIS LVYHQ*YLTEGSVISYEYGYPQFLRQLVNVFVKI VYIFTESLFL*NEGSIEFTLVFFIPF*TLQLP* LGTCFLQLFYAKLCSVQF*SVYRTN*CVTVCRL VVVEQI**LCRFKFSYLILVSIP*VFL*KPGIER LMNGNSFTSLYASFQ*LGLSGVLRLLMTYK*WA LIGQYSFEFLPFDLI*LVKFKVNSWAHL*SFY* KIFS*MELISCVHIKRSHQVDGETFDPLFA**II K*WLGKAG*SNHGAIIRLACYTHRSKPSMSIKQ ILTVLFLLMIPKPCCKFLHWHLWISVLMFVLSD LTFYFLSFLEIADCSAPSTDIYINSYSFPLPSLN SF*PF*ILAL*NPCWKPE*PSLPTKSPQTFHLS RT*SC*QVVIPWVL*H*QSLRGGRKSLFLGLVS FQLLFYPVFGGNVSKVPSGIFRGKNIL*GFL*SF LCIGVCSLKFTERGELC*TSEFKSY**TEESVY IGTRVI*KLQSRNMTFSLWTPFKNRYE*DD*EC NGEELPCLPISEP*GHLC*SYFYLCIYRS*S*AA YLYHVSLRT*KHFM*FLINLKIWLR*LKKPVCQ IQWKQVHRCELVFRGPTSQFIRYDCGNTDKDLS *YFGLGAVRA*DTPSGLGKEEGSGGFIGGGGGRW SKC*LAT*FGQILQKGKGGFA*KDGAPSDYFLT SVCLTLLSGKNMQSSSVSCTFCGG*TPWFWLNS CTFDSCARKG*DQLQINVGCQM*CVSLTFCFS*E KKINLLFKYRV

Frame 2

RPPAARRRLRRWKPRPLTPSCRPKRSWTGTSRS LSGSGRLSCRCWSWSGNLVITPVRTGHYPRRRR QQRRRRTSCTGSRWRLSLGTFGSRPPAPRTQSQ WAGLGPPAGRRWRPYDGLGMACSATTRRPSKVRG FINRQGLTPFFPSLPGLTRQGWVGNRNESVLKR VSSYS*SQNILAMSHCFRPS*FFWKWQLLFKDR KGWDVNFKWGQPEFCKSQ*RFSRRGWAGESCAGL DKGGREDLHAFLSQACFGNWTSKTKTM*NRCLE **SMFSATA*QTGAGL*LSFLLVPLWLNT*RP* TKKAASNH*QKVSQTFS*GQNGTG*LNKEAGMGL WSSSM*RT*KVASGMCCWLLQVLLE*ELVWHI* *DSLTVSAIVDF*PTTTTTKTSLCSWTPSCNFL ELHPSNLARKASGKRIMANKNKYMGRVLPID*RV TV*KKQSSVSATNKLCLGSYGGGLLDLVKMVGW KDLISLLRTGKWPVARQVIELITRRIH*FTVVL REALRMPVTCVKVTSNRTMTVSLSTVQGKLFLSL ISFPSILLRKSKCSGLLYLLYFGLVSMILTLLA *FITNNT*RKAQ*LVMNMDILNS*DSL*MYL*K LYIFLQKVYFFETKEVSNLH*FFSYPFELCNFRN *EPVSYSFSMLNFVLFSSRVYTERIDV*LYADW L*WNKSDNYAGLNFLI*FW*VFLRFFFENLGLR G**MEILSLHYMQVFNN*V*VEF*GY**LTNNGL *LGNTHLSSFHLT*FNW*NLK*IHGLIFKAFTK RFSAEWNSLAVCI*KDHIRWMERHLIPCLLNKL *NDGLEKQASLTMVLLLGLLVTHTGLSLVCQ*SK YLLFCFY**FPNLVASFCIGIFGFQS*CLFYQT *PFISCPSLKLLIVLLPLQIFISIPTAFPCHP* TLSSPFRFWHCETPAGNLSDPPSPPRVHRPFIFH ELDPVSRW*YHGCCDTNSH*EVGGSPFSLDWYL FNYCFILSLGAMCQKSPQEFSEERTFYEAFSKV SFV*EYAHLNLQKEVSCVKPQSLKATDKLKKVSI LELGSFESFSLGT*PLVCGLHLKIGMNKMTKNV MGKNCPACPSQSHKVIFARAIFTYVFIVLDHKP LIYIMYL*GPKSTLCSF*LILRSGYGN*KSLSAK SSGNKCIDVNWFLGAPLPNSLGMTVEIQTRILV DILGLGQ*GLRTPQVVWERRRGVVGL*GEEEAG GLSADWLRSSGKSSKREREDLLRRMALPVTTF*L LFVLRFSQGKTCSPLVFHVHSVGGEHLGSG*TA VLLIAVPGRVRTNYKLMLVVKCSVFP*LSVFPE KKK*IFYSNTG