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Sequences

Sequence MCL1.aAug05

CCGGCCCCGGCCCCGGCCCCGGCCCCGCCCCGGCCCGGCCGGGCAGCTGGTAGGTGCCGTGCGCAACCCTCCGGAAGCTGCCGCCCCTTTCCCCTTTTAT GGGAATACTTTTTTTAAAAAAAAAGAGTTCGCTGGCGCCACCCCGTAGGACTGGCCGCCCTAAAACCGTGATAAAGGAGCTGCTCGCCACTTCTCACTTC CGCTTCCTTCCAGTAAGGAGTCGGGGTCTTCCCCAGTTTTCTCAGCCAGGCGGCGGCGGCGACTGGCAATGTTTGGCCTCAAAAGAAACGCGGTAATCGG ACTCAACCTCTACTGTGGGGGGGCCGGCTTGGGGGCCGGCAGCGGCGGCGCCACCCGCCCGGGAGGGCGACTTTTGGCTACGGAGAAGGAGGCCTCGGCC CGGCGAGAGATAGGGGGAGGGGAGGCCGGCGCGGTGATTGGCGGAAGCGCCGGCGCAAGCCCCCCGTCCACCCTCACGCCAGACTCCCGGAGGGTCGCGC GGCCGCCGCCCATTGGCGCCGAGGTCCCCGACGTCACCGCGACCCCCGCGAGGCTGCTTTTCTTCGCGCCCACCCGCCGCGCGGCGCCGCTTGAGGAGAT GGAAGCCCCGGCCGCTGACGCCATCATGTCGCCCGAAGAGGAGCTGGACGGGTACGAGCCGGAGCCTCTCGGGAAGCGGCCGGCTGTCCTGCCGCTGCTG GAGTTGGTCGGGGAATCTGGTAATAACACCAGTACGGACGGGTCACTACCCTCGACGCCGCCGCCAGCAGAGGAGGAGGAGGACGAGTTGTACCGGCAGT CGCTGGAGATTATCTCTCGGTACCTTCGGGAGCAGGCCACCGGCGCCAAGGACACAAAGCCAATGGGCAGGTCTGGGGCCACCAGCAGGAAGGCGCTGGA GACCTTACGACGGGTTGGGGATGGCGTGCAGCGCAACCACGAGACGGCCTTCCAAGGCATGCTTCGGAAACTGGACATCAAAAACGAAGACGATGTGAAA TCGTTGTCTCGAGTGATGATCCATGTTTTCAGCGACGGCGTAACAAACTGGGGCAGGATTGTGACTCTCATTTCTTTTGGTGCCTTTGTGGCTAAACACT TGAAGACCATAAACCAAGAAAGCTGCATCGAACCATTAGCAGAAAGTATCACAGACGTTCTCGTAAGGACAAAACGGGACTGGCTAGTTAAACAAAGAGG CTGGGATGGGTTTGTGGAGTTCTTCCATGTAGAGGACCTAGAAGGTGGCATCAGGAATGTGCTGCTGGCTTTTGCAGGTGTTGCTGGAGTAGGAGCTGGT TTGGCATATCTAATAAGATAGCCTTACTGTAAGTGCAATAGTTGACTTTTAACCAACCACCACCACCACCAAAACCAGTTTATGCAGTTGGACTCCAAGC TGTAACTTCCTAGAGTTGCACCCTAGCAACCTAGCCAGAAAAGCAAGTGGCAAGAGGATTATGGCTAACAAGAATAAATACATGGGAAGAGTGCTCCCCA TTGATTGAAGAGTCACTGTCTGAAAGAAGCAAAGTTCAGTTTCAGCAACAAACAAACTTTGTTTGGGAAGCTATGGAGGAGGACTTTTAGATTTAGTGAA GATGGTAGGGTGGAAAGACTTAATTTCCTTGTTGAGAACAGGAAAGTGGCCAGTAGCCAGGCAAGTCATAGAATTGATTACCCGCCGAATTCATTAATTT ACTGTAGTGTTAAGAGAAGCACTAAGAATGCCAGTGACCTGTGTAAAAGTTACAAGTAATAGAACTATGACTGTAAGCCTCAGTACTGTACAAGGGAAGC TTTTCCTCTCTCTAATTAGCTTTCCCAGTATACTTCTTAGAAAGTCCAAGTGTTCAGGACTTTTATACCTGTTATACTTTGGCTTGGTTTCCATGATTCT TACTTTATTAGCCTAGTTTATCACCAATAATACTTGACGGAAGGCTCAGTAATTAGTTATGAATATGGATATCCTCAATTCTTAAGACAGCTTGTAAATG TATTTGTAAAAATTGTATATATTTTTACAGAAAGTCTATTTCTTTGAAACGAAGGAAGTATCGAATTTACATTAGTTTTTTTCATACCCTTTTGAACTTT GCAACTTCCGTAATTAGGAACCTGTTTCTTACAGCTTTTCTATGCTAAACTTTGTTCTGTTCAGTTCTAGAGTGTATACAGAACGAATTGATGTGTAACT GTATGCAGACTGGTTGTAGTGGAACAAATCTGATAACTATGCAGGTTTAAATTTTCTTATCTGATTTTGGTAAGTATTCCTTAGGTTTTTCTTTGAAAAC CTGGGATTGAGAGGTTGATGAATGGAAATTCTTTCACTTCATTATATGCAAGTTTTCAATAATTAGGTCTAAGTGGAGTTTTAAGGTTACTGATGACTTA CAAATAATGGGCTCTGATTGGGCAATACTCATTTGAGTTCCTTCCATTTGACCTAATTTAACTGGTGAAATTTAAAGTGAATTCATGGGCTCATCTTTAA AGCTTTTACTAAAAGATTTTCAGCTGAATGGAACTCATTAGCTGTGTGCATATAAAAAGATCACATCAGGTGGATGGAGAGACATTTGATCCCTTGTTTG CTTAATAAATTATAAAATGATGGCTTGGAAAAGCAGGCTAGTCTAACCATGGTGCTATTATTAGGCTTGCTTGTTACACACACAGGTCTAAGCCTAGTAT GTCAATAAAGCAAATACTTACTGTTTTGTTTCTATTAATGATTCCCAAACCTTGTTGCAAGTTTTTGCATTGGCATCTTTGGATTTCAGTCTTGATGTTT GTTCTATCAGACTTAACCTTTTATTTCCTGTCCTTCCTTGAAATTGCTGATTGTTCTGCTCCCTCTACAGATATTTATATCAATTCCTACAGCTTTCCCC TGCCATCCCTGAACTCTTTCTAGCCCTTTTAGATTTTGGCACTGTGAAACCCCTGCTGGAAACCTGAGTGACCCTCCCTCCCCACCAAGAGTCCACAGAC CTTTCATCTTTCACGAACTTGATCCTGTTAGCAGGTGGTAATACCATGGGTGCTGTGACACTAACAGTCATTGAGAGGTGGGAGGAAGTCCCTTTTCCTT GGACTGGTATCTTTTCAACTATTGTTTTATCCTGTCTTTGGGGGCAATGTGTCAAAAGTCCCCTCAGGAATTTTCAGAGGAAAGAACATTTTATGAGGCT TTCTCTAAAGTTTCCTTTGTATAGGAGTATGCTCACTTAAATTTACAGAAAGAGGTGAGCTGTGTTAAACCTCAGAGTTTAAAAGCTACTGATAAACTGA AGAAAGTGTCTATATTGGAACTAGGGTCATTTGAAAGCTTCAGTCTCGGAACATGACCTTTAGTCTGTGGACTCCATTTAAAAATAGGTATGAATAAGAT GACTAAGAATGTAATGGGGAAGAACTGCCCTGCCTGCCCATCTCAGAGCCATAAGGTCATCTTTGCTAGAGCTATTTTTACCTATGTATTTATCGTTCTT GATCATAAGCCGCTTATTTATATCATGTATCTCTAAGGACCTAAAAGCACTTTATGTAGTTTTTAATTAATCTTAAGATCTGGTTACGGTAACTAAAAAA GCCTGTCTGCCAAATCCAGTGGAAACAAGTGCATAGATGTGAATTGGTTTTTAGGGGCCCCACTTCCCAATTCATTAGGTATGACTGTGGAAATACAGAC AAGGATCTTAGTTGATATTTTGGGCTTGGGGCAGTGAGGGCTTAGGACACCCCAAGTGGTTTGGGAAAGGAGGAGGGGAGTGGTGGGTTTATAGGGGGAG GAGGAGGCAGGTGGTCTAAGTGCTGACTGGCTACGTAGTTCGGGCAAATCCTCCAAAAGGGAAAGGGAGGATTTGCTTAGAAGGATGGCGCTCCCAGTGA CTACTTTTTGACTTCTGTTTGTCTTACGCTTCTCTCAGGGAAAAACATGCAGTCCTCTAGTGTTTCATGTACATTCTGTGGGGGGTGAACACCTTGGTTC TGGTTAAACAGCTGTACTTTTGATAGCTGTGCCAGGAAGGGTTAGGACCAACTACAAATTAATGTTGGTTGTCAAATGTAGTGTGTTTCCCTAACTTTCT GTTTTTCCTGAGAAAAAAAAATAAATCTTTTATTCAAATACAGGGTG

MCL1.F1 (forward primer)
MCL1.R1 (reverse primer)
Intron retention

Frame 0

PAPAPAPAPPRPGRAAGRCRAQPSGSCRPFPLL WEYFF*KKRVRWRHPVGLAALKP**RSCSPLLTS ASFQ*GVGVFPSFLSQAAAATGNVWPQKKRGNR TQPLLWGGRLGGRQRRRHPPGRATFGYGEGGLG PARDRGRGGRRGDWRKRRRKPPVHPHARLPEGRA AAAHWRRGPRRHRDPREAAFLRAHPPRGAA*GD GSPGR*RHHVARRGAGRVRAGASREAAGCPAAA GVGRGIW**HQYGRVTTLDAAASRGGGGRVVPAV AGDYLSVPSGAGHRRQGHKANGQVWGHQQEGAG DLTTGWGWRAAQPRDGLPRHASETGHQKRRRCE IVVSSDDPCFQRRRNKLGQDCDSHFFWCLCG*TL EDHKPRKLHRTISRKYHRRSRKDKTGLAS*TKR LGWVCGVLPCRGPRRWHQECAAGFCRCCWSRSW FGISNKIALL*VQ*LTFNQPPPPPKPVYAVGLQA VTS*SCTLAT*PEKQVARGLWLTRINTWEECSP LIEESLSERSKVQFQQQTNFVWEAMEEDF*I** RW*GGKT*FPC*EQESGQ*PGKS*N*LPAEFINL L*C*EKH*ECQ*PV*KLQVIEL*L*ASVLYKGS FSSL*LAFPVYFLESPSVQDFYTCYTLAWFP*F LLY*PSLSPIILDGRLSN*L*IWISSILKTACKC ICKNCIYFYRKSISLKRRKYRIYISFFHTLLNF ATSVIRNLFLTAFLC*TLFCSVLECIQNELMCN CMQTGCSGTNLITMQV*IFLSDFGKYSLGFSLKT WD*EVDEWKFFHFIICKFSIIRSKWSFKVTDDL QIMGSDWAILI*VPSI*PNLTGEI*SEFMGSSL KLLLKDFQLNGTH*LCAYKKITSGGWRDI*SLVC LINYKMMAWKSRLV*PWCYY*ACLLHTQV*A*Y VNKANTYCFVSINDSQTLLQVFALASLDFSLDV CSIRLNLLFPVLP*NC*LFCSLYRYLYQFLQLSP AIPELFLALLDFGTVKPLLET*VTLPPHQESTD LSSFTNLILLAGGNTMGAVTLTVIERWEEVPFP WTGIFSTIVLSCLWGQCVKSPLRNFQRKEHFMRL SLKFPLYRSMLT*IYRKR*AVLNLRV*KLLIN* RKCLYWN*GHLKASVSEHDL*SVDSI*K*V*IR *LRM*WGRTALPAHLRAIRSSLLELFLPMYLSFL IISRLFISCISKDLKALYVVFN*S*DLVTVTKK ACLPNPVETSA*M*IGF*GPHFPIH*V*LWKYR QGS*LIFWAWGSEGLGHPKWFGKGGGEWWVYRGR RRQVV*VLTGYVVRANPPKGKGRICLEGWRSQ* LLFDFCLSYASLREKHAVL*CFMYILWGVNTLV LVKQLYF**LCQEGLGPTTN*CWLSNVVCFPNFL FFLRKKNKSFIQIQG

Frame 1

RPRPRPRPRPGPAGQLVGAVRNPPEAAAPFPFY GNTFFKKKEFAGATP*DWPP*NRDKGAARHFSL PLPSSKESGSSPVFSARRRRRLAMFGLKRNAVIG LNLYCGGAGLGAGSGGATRPGGRLLATEKEASA RREIGGGEAGAVIGGSAGASPPSTLTPDSRRVA RPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEM EAPAADAIMSPEEELDGYEPEPLGKRPAVLPLL ELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQ SLEIISRYLREQATGAKDTKPMGRSGATSRKALE TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVK SLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKH LKTINQESCIEPLAESITDVLVRTKRDWLVKQRG WDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAG LAYLIR*PYCKCNS*LLTNHHHHQNQFMQLDSK L*LPRVAP*QPSQKSKWQEDYG*QE*IHGKSAPH *LKSHCLKEAKFSFSNKQTLFGKLWRRTFRFSE DGRVERLNFLVENRKVASSQASHRIDYPPNSLI YCSVKRSTKNASDLCKSYK**NYDCKPQYCTREA FPLSN*LSQYTS*KVQVFRTFIPVILWLGFHDS YFISLVYHQ*YLTEGSVISYEYGYPQFLRQLVN VFVKIVYIFTESLFL*NEGSIEFTLVFFIPF*TL QLP*LGTCFLQLFYAKLCSVQF*SVYRTN*CVT VCRLVVVEQI**LCRFKFSYLILVSIP*VFL*K PGIERLMNGNSFTSLYASFQ*LGLSGVLRLLMTY K*WALIGQYSFEFLPFDLI*LVKFKVNSWAHL* SFY*KIFS*MELISCVHIKRSHQVDGETFDPLF A**IIK*WLGKAG*SNHGAIIRLACYTHRSKPSM SIKQILTVLFLLMIPKPCCKFLHWHLWISVLMF VLSDLTFYFLSFLEIADCSAPSTDIYINSYSFP LPSLNSF*PF*ILAL*NPCWKPE*PSLPTKSPQT FHLSRT*SC*QVVIPWVL*H*QSLRGGRKSLFL GLVSFQLLFYPVFGGNVSKVPSGIFRGKNIL*G FL*SFLCIGVCSLKFTERGELC*TSEFKSY**TE ESVYIGTRVI*KLQSRNMTFSLWTPFKNRYE*D D*ECNGEELPCLPISEP*GHLC*SYFYLCIYRS *S*AAYLYHVSLRT*KHFM*FLINLKIWLR*LKK PVCQIQWKQVHRCELVFRGPTSQFIRYDCGNTD KDLS*YFGLGAVRA*DTPSGLGKEEGSGGFIGG GGGRWSKC*LAT*FGQILQKGKGGFA*KDGAPSD YFLTSVCLTLLSGKNMQSSSVSCTFCGG*TPWF WLNSCTFDSCARKG*DQLQINVGCQM*CVSLTF CFS*EKKINLLFKYRV

Frame 2

GPGPGPGPAPARPGSW*VPCATLRKLPPLSPFM GILFLKKKSSLAPPRRTGRPKTVIKELLATSHF RFLPVRSRGLPQFSQPGGGGDWQCLASKETR*S DSTSTVGGPAWGPAAAAPPAREGDFWLRRRRPRP GER*GEGRPAR*LAEAPAQAPRPPSRQTPGGSR GRRPLAPRSPTSPRPPRGCFSSRPPAARRRLRR WKPRPLTPSCRPKRSWTGTSRSLSGSGRLSCRCW SWSGNLVITPVRTGHYPRRRRQQRRRRTSCTGS RWRLSLGTFGSRPPAPRTQSQWAGLGPPAGRRW RPYDGLGMACSATTRRPSKACFGNWTSKTKTM*N RCLE**SMFSATA*QTGAGL*LSFLLVPLWLNT *RP*TKKAASNH*QKVSQTFS*GQNGTG*LNKE AGMGLWSSSM*RT*KVASGMCCWLLQVLLE*ELV WHI**DSLTVSAIVDF*PTTTTTKTSLCSWTPS CNFLELHPSNLARKASGKRIMANKNKYMGRVLP ID*RVTV*KKQSSVSATNKLCLGSYGGGLLDLVK MVGWKDLISLLRTGKWPVARQVIELITRRIH*F TVVLREALRMPVTCVKVTSNRTMTVSLSTVQGK LFLSLISFPSILLRKSKCSGLLYLLYFGLVSMIL TLLA*FITNNT*RKAQ*LVMNMDILNS*DSL*M YL*KLYIFLQKVYFFETKEVSNLH*FFSYPFEL CNFRN*EPVSYSFSMLNFVLFSSRVYTERIDV*L YADWL*WNKSDNYAGLNFLI*FW*VFLRFFFEN LGLRG**MEILSLHYMQVFNN*V*VEF*GY**L TNNGL*LGNTHLSSFHLT*FNW*NLK*IHGLIFK AFTKRFSAEWNSLAVCI*KDHIRWMERHLIPCL LNKL*NDGLEKQASLTMVLLLGLLVTHTGLSLV CQ*SKYLLFCFY**FPNLVASFCIGIFGFQS*CL FYQT*PFISCPSLKLLIVLLPLQIFISIPTAFP CHP*TLSSPFRFWHCETPAGNLSDPPSPPRVHR PFIFHELDPVSRW*YHGCCDTNSH*EVGGSPFSL DWYLFNYCFILSLGAMCQKSPQEFSEERTFYEA FSKVSFV*EYAHLNLQKEVSCVKPQSLKATDKL KKVSILELGSFESFSLGT*PLVCGLHLKIGMNKM TKNVMGKNCPACPSQSHKVIFARAIFTYVFIVL DHKPLIYIMYL*GPKSTLCSF*LILRSGYGN*K SLSAKSSGNKCIDVNWFLGAPLPNSLGMTVEIQT RILVDILGLGQ*GLRTPQVVWERRRGVVGL*GE EEAGGLSADWLRSSGKSSKREREDLLRRMALPV TTF*LLFVLRFSQGKTCSPLVFHVHSVGGEHLGS G*TAVLLIAVPGRVRTNYKLMLVVKCSVFP*LS VFPEKKK*IFYSNTG

Sequence MCL1.cAug05

CGCGCCCACCCGCCGCGCGGCGCCGCTTGAGGAGATGGAAGCCCCGGCCGCTGACGCCATCATGTCGCCCGAAGAGGAGCTGGACGGGTACGAGCCGGAG CCTCTCGGGAAGCGGCCGGCTGTCCTGCCGCTGCTGGAGTTGGTCGGGGAATCTGGTAATAACACCAGTACGGACGGGTCACTACCCTCGACGCCGCCGC CAGCAGAGGAGGAGGAGGACGAGTTGTACCGGCAGTCGCTGGAGATTATCTCTCGGTACCTTCGGGAGCAGGCCACCGGCGCCAAGGACACAAAGCCAAT GGGCAGGTCTGGGGCCACCAGCAGGAAGGCGCTGGAGACCTTACGACGGGTTGGGGATGGCGTGCAGCGCAACCACGAGACGGCCTTCCAAGGTAAGGGG GTTCATTAATCGCCAAGGCCTCACTCCCTTTTTTCCATCTCTCCCCGGACTCACCCGCCAAGGGTGGGTTGGAAACCGAAACGAGTCAGTGTTGAAACGT GTCTCATCCTATTCCTGAAGCCAGAATATTCTGGCCATGAGTCATTGTTTCCGCCCATCTTGATTCTTTTGGAAATGGCAGCTCTTGTTCAAAGACCGGA AAGGGTGGGATGTCAATTTCAAGTGGGGTCAACCTGAGTTCTGTAAATCCCAGTAGCGATTTTCCCGCCGCGGGTGGGCAGGCGAATCTTGCGCCGGTTT AGACAAAGGAGGCCGTGAGGACCTGCATGCTTTTCTTTCTCAGGCATGCTTCGGAAACTGGACATCAAAAACGAAGACGATGTGAAATCGTTGTCTCGAG TGATGATCCATGTTTTCAGCGACGGCGTAACAAACTGGGGCAGGATTGTGACTCTCATTTCTTTTGGTGCCTTTGTGGCTAAACACTTGAAGACCATAAA CCAAGAAAGCTGCATCGAACCATTAGCAGAAAGTATCACAGACGTTCTCGTAAGGACAAAACGGGACTGGCTAGTTAAACAAAGAGGCTGGGATGGGTTT GTGGAGTTCTTCCATGTAGAGGACCTAGAAGGTGGCATCAGGAATGTGCTGCTGGCTTTTGCAGGTGTTGCTGGAGTAGGAGCTGGTTTGGCATATCTAA TAAGATAGCCTTACTGTAAGTGCAATAGTTGACTTTTAACCAACCACCACCACCACCAAAACCAGTTTATGCAGTTGGACTCCAAGCTGTAACTTCCTAG AGTTGCACCCTAGCAACCTAGCCAGAAAAGCAAGTGGCAAGAGGATTATGGCTAACAAGAATAAATACATGGGAAGAGTGCTCCCCATTGATTGAAGAGT CACTGTCTGAAAGAAGCAAAGTTCAGTTTCAGCAACAAACAAACTTTGTTTGGGAAGCTATGGAGGAGGACTTTTAGATTTAGTGAAGATGGTAGGGTGG AAAGACTTAATTTCCTTGTTGAGAACAGGAAAGTGGCCAGTAGCCAGGCAAGTCATAGAATTGATTACCCGCCGAATTCATTAATTTACTGTAGTGTTAA GAGAAGCACTAAGAATGCCAGTGACCTGTGTAAAAGTTACAAGTAATAGAACTATGACTGTAAGCCTCAGTACTGTACAAGGGAAGCTTTTCCTCTCTCT AATTAGCTTTCCCAGTATACTTCTTAGAAAGTCCAAGTGTTCAGGACTTTTATACCTGTTATACTTTGGCTTGGTTTCCATGATTCTTACTTTATTAGCC TAGTTTATCACCAATAATACTTGACGGAAGGCTCAGTAATTAGTTATGAATATGGATATCCTCAATTCTTAAGACAGCTTGTAAATGTATTTGTAAAAAT TGTATATATTTTTACAGAAAGTCTATTTCTTTGAAACGAAGGAAGTATCGAATTTACATTAGTTTTTTTCATACCCTTTTGAACTTTGCAACTTCCGTAA TTAGGAACCTGTTTCTTACAGCTTTTCTATGCTAAACTTTGTTCTGTTCAGTTCTAGAGTGTATACAGAACGAATTGATGTGTAACTGTATGCAGACTGG TTGTAGTGGAACAAATCTGATAACTATGCAGGTTTAAATTTTCTTATCTGATTTTGGTAAGTATTCCTTAGGTTTTTCTTTGAAAACCTGGGATTGAGAG GTTGATGAATGGAAATTCTTTCACTTCATTATATGCAAGTTTTCAATAATTAGGTCTAAGTGGAGTTTTAAGGTTACTGATGACTTACAAATAATGGGCT CTGATTGGGCAATACTCATTTGAGTTCCTTCCATTTGACCTAATTTAACTGGTGAAATTTAAAGTGAATTCATGGGCTCATCTTTAAAGCTTTTACTAAA AGATTTTCAGCTGAATGGAACTCATTAGCTGTGTGCATATAAAAAGATCACATCAGGTGGATGGAGAGACATTTGATCCCTTGTTTGCTTAATAAATTAT AAAATGATGGCTTGGAAAAGCAGGCTAGTCTAACCATGGTGCTATTATTAGGCTTGCTTGTTACACACACAGGTCTAAGCCTAGTATGTCAATAAAGCAA ATACTTACTGTTTTGTTTCTATTAATGATTCCCAAACCTTGTTGCAAGTTTTTGCATTGGCATCTTTGGATTTCAGTCTTGATGTTTGTTCTATCAGACT TAACCTTTTATTTCCTGTCCTTCCTTGAAATTGCTGATTGTTCTGCTCCCTCTACAGATATTTATATCAATTCCTACAGCTTTCCCCTGCCATCCCTGAA CTCTTTCTAGCCCTTTTAGATTTTGGCACTGTGAAACCCCTGCTGGAAACCTGAGTGACCCTCCCTCCCCACCAAGAGTCCACAGACCTTTCATCTTTCA CGAACTTGATCCTGTTAGCAGGTGGTAATACCATGGGTGCTGTGACACTAACAGTCATTGAGAGGTGGGAGGAAGTCCCTTTTCCTTGGACTGGTATCTT TTCAACTATTGTTTTATCCTGTCTTTGGGGGCAATGTGTCAAAAGTCCCCTCAGGAATTTTCAGAGGAAAGAACATTTTATGAGGCTTTCTCTAAAGTTT CCTTTGTATAGGAGTATGCTCACTTAAATTTACAGAAAGAGGTGAGCTGTGTTAAACCTCAGAGTTTAAAAGCTACTGATAAACTGAAGAAAGTGTCTAT ATTGGAACTAGGGTCATTTGAAAGCTTCAGTCTCGGAACATGACCTTTAGTCTGTGGACTCCATTTAAAAATAGGTATGAATAAGATGACTAAGAATGTA ATGGGGAAGAACTGCCCTGCCTGCCCATCTCAGAGCCATAAGGTCATCTTTGCTAGAGCTATTTTTACCTATGTATTTATCGTTCTTGATCATAAGCCGC TTATTTATATCATGTATCTCTAAGGACCTAAAAGCACTTTATGTAGTTTTTAATTAATCTTAAGATCTGGTTACGGTAACTAAAAAAGCCTGTCTGCCAA ATCCAGTGGAAACAAGTGCATAGATGTGAATTGGTTTTTAGGGGCCCCACTTCCCAATTCATTAGGTATGACTGTGGAAATACAGACAAGGATCTTAGTT GATATTTTGGGCTTGGGGCAGTGAGGGCTTAGGACACCCCAAGTGGTTTGGGAAAGGAGGAGGGGAGTGGTGGGTTTATAGGGGGAGGAGGAGGCAGGTG GTCTAAGTGCTGACTGGCTACGTAGTTCGGGCAAATCCTCCAAAAGGGAAAGGGAGGATTTGCTTAGAAGGATGGCGCTCCCAGTGACTACTTTTTGACT TCTGTTTGTCTTACGCTTCTCTCAGGGAAAAACATGCAGTCCTCTAGTGTTTCATGTACATTCTGTGGGGGGTGAACACCTTGGTTCTGGTTAAACAGCT GTACTTTTGATAGCTGTGCCAGGAAGGGTTAGGACCAACTACAAATTAATGTTGGTTGTCAAATGTAGTGTGTTTCCCTAACTTTCTGTTTTTCCTGAGA AAAAAAAATAAATCTTTTATTCAAATACAGGGTG

MCL1.F1 (forward primer)
MCL1.R1 (reverse primer)
Intron retention

Frame 0

RAHPPRGAA*GDGSPGR*RHHVARRGAGRVRAG ASREAAGCPAAAGVGRGIW**HQYGRVTTLDAAA SRGGGGRVVPAVAGDYLSVPSGAGHRRQGHKAN GQVWGHQQEGAGDLTTGWGWRAAQPRDGLPR*G GSLIAKASLPFFHLSPDSPAKGGLETETSQC*NV SHPIPEARIFWP*VIVSAHLDSFGNGSSCSKTG KGGMSISSGVNLSSVNPSSDFPAAGGQANLAPV *TKEAVRTCMLFFLRHASETGHQKRRRCEIVVSS DDPCFQRRRNKLGQDCDSHFFWCLCG*TLEDHK PRKLHRTISRKYHRRSRKDKTGLAS*TKRLGWV CGVLPCRGPRRWHQECAAGFCRCCWSRSWFGISN KIALL*VQ*LTFNQPPPPPKPVYAVGLQAVTS* SCTLAT*PEKQVARGLWLTRINTWEECSPLIEE SLSERSKVQFQQQTNFVWEAMEEDF*I**RW*GG KT*FPC*EQESGQ*PGKS*N*LPAEFINLL*C* EKH*ECQ*PV*KLQVIEL*L*ASVLYKGSFSSL *LAFPVYFLESPSVQDFYTCYTLAWFP*FLLY*P SLSPIILDGRLSN*L*IWISSILKTACKCICKN CIYFYRKSISLKRRKYRIYISFFHTLLNFATSV IRNLFLTAFLC*TLFCSVLECIQNELMCNCMQTG CSGTNLITMQV*IFLSDFGKYSLGFSLKTWD*E VDEWKFFHFIICKFSIIRSKWSFKVTDDLQIMG SDWAILI*VPSI*PNLTGEI*SEFMGSSLKLLLK DFQLNGTH*LCAYKKITSGGWRDI*SLVCLINY KMMAWKSRLV*PWCYY*ACLLHTQV*A*YVNKA NTYCFVSINDSQTLLQVFALASLDFSLDVCSIRL NLLFPVLP*NC*LFCSLYRYLYQFLQLSPAIPE LFLALLDFGTVKPLLET*VTLPPHQESTDLSSF TNLILLAGGNTMGAVTLTVIERWEEVPFPWTGIF STIVLSCLWGQCVKSPLRNFQRKEHFMRLSLKF PLYRSMLT*IYRKR*AVLNLRV*KLLIN*RKCL YWN*GHLKASVSEHDL*SVDSI*K*V*IR*LRM* WGRTALPAHLRAIRSSLLELFLPMYLSFLIISR LFISCISKDLKALYVVFN*S*DLVTVTKKACLP NPVETSA*M*IGF*GPHFPIH*V*LWKYRQGS*L IFWAWGSEGLGHPKWFGKGGGEWWVYRGRRRQV V*VLTGYVVRANPPKGKGRICLEGWRSQ*LLFD FCLSYASLREKHAVL*CFMYILWGVNTLVLVKQL YF**LCQEGLGPTTN*CWLSNVVCFPNFLFFLR KKNKSFIQIQG

Frame 1

APTRRAAPLEEMEAPAADAIMSPEEELDGYEPE PLGKRPAVLPLLELVGESGNNTSTDGSLPSTPP PAEEEEDELYRQSLEIISRYLREQATGAKDTKPM GRSGATSRKALETLRRVGDGVQRNHETAFQGKG VH*SPRPHSLFSISPRTHPPRVGWKPKRVSVET CLILFLKPEYSGHESLFPPILILLEMAALVQRPE RVGCQFQVGST*VL*IPVAIFPPRVGRRILRRF RQRRP*GPACFSFSGMLRKLDIKNEDDVKSLSR VMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTIN QESCIEPLAESITDVLVRTKRDWLVKQRGWDGF VEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYL IR*PYCKCNS*LLTNHHHHQNQFMQLDSKL*LPR VAP*QPSQKSKWQEDYG*QE*IHGKSAPH*LKS HCLKEAKFSFSNKQTLFGKLWRRTFRFSEDGRV ERLNFLVENRKVASSQASHRIDYPPNSLIYCSVK RSTKNASDLCKSYK**NYDCKPQYCTREAFPLS N*LSQYTS*KVQVFRTFIPVILWLGFHDSYFIS LVYHQ*YLTEGSVISYEYGYPQFLRQLVNVFVKI VYIFTESLFL*NEGSIEFTLVFFIPF*TLQLP* LGTCFLQLFYAKLCSVQF*SVYRTN*CVTVCRL VVVEQI**LCRFKFSYLILVSIP*VFL*KPGIER LMNGNSFTSLYASFQ*LGLSGVLRLLMTYK*WA LIGQYSFEFLPFDLI*LVKFKVNSWAHL*SFY* KIFS*MELISCVHIKRSHQVDGETFDPLFA**II K*WLGKAG*SNHGAIIRLACYTHRSKPSMSIKQ ILTVLFLLMIPKPCCKFLHWHLWISVLMFVLSD LTFYFLSFLEIADCSAPSTDIYINSYSFPLPSLN SF*PF*ILAL*NPCWKPE*PSLPTKSPQTFHLS RT*SC*QVVIPWVL*H*QSLRGGRKSLFLGLVS FQLLFYPVFGGNVSKVPSGIFRGKNIL*GFL*SF LCIGVCSLKFTERGELC*TSEFKSY**TEESVY IGTRVI*KLQSRNMTFSLWTPFKNRYE*DD*EC NGEELPCLPISEP*GHLC*SYFYLCIYRS*S*AA YLYHVSLRT*KHFM*FLINLKIWLR*LKKPVCQ IQWKQVHRCELVFRGPTSQFIRYDCGNTDKDLS *YFGLGAVRA*DTPSGLGKEEGSGGFIGGGGGRW SKC*LAT*FGQILQKGKGGFA*KDGAPSDYFLT SVCLTLLSGKNMQSSSVSCTFCGG*TPWFWLNS CTFDSCARKG*DQLQINVGCQM*CVSLTFCFS*E KKINLLFKYRV

Frame 2

RPPAARRRLRRWKPRPLTPSCRPKRSWTGTSRS LSGSGRLSCRCWSWSGNLVITPVRTGHYPRRRR QQRRRRTSCTGSRWRLSLGTFGSRPPAPRTQSQ WAGLGPPAGRRWRPYDGLGMACSATTRRPSKVRG FINRQGLTPFFPSLPGLTRQGWVGNRNESVLKR VSSYS*SQNILAMSHCFRPS*FFWKWQLLFKDR KGWDVNFKWGQPEFCKSQ*RFSRRGWAGESCAGL DKGGREDLHAFLSQACFGNWTSKTKTM*NRCLE **SMFSATA*QTGAGL*LSFLLVPLWLNT*RP* TKKAASNH*QKVSQTFS*GQNGTG*LNKEAGMGL WSSSM*RT*KVASGMCCWLLQVLLE*ELVWHI* *DSLTVSAIVDF*PTTTTTKTSLCSWTPSCNFL ELHPSNLARKASGKRIMANKNKYMGRVLPID*RV TV*KKQSSVSATNKLCLGSYGGGLLDLVKMVGW KDLISLLRTGKWPVARQVIELITRRIH*FTVVL REALRMPVTCVKVTSNRTMTVSLSTVQGKLFLSL ISFPSILLRKSKCSGLLYLLYFGLVSMILTLLA *FITNNT*RKAQ*LVMNMDILNS*DSL*MYL*K LYIFLQKVYFFETKEVSNLH*FFSYPFELCNFRN *EPVSYSFSMLNFVLFSSRVYTERIDV*LYADW L*WNKSDNYAGLNFLI*FW*VFLRFFFENLGLR G**MEILSLHYMQVFNN*V*VEF*GY**LTNNGL *LGNTHLSSFHLT*FNW*NLK*IHGLIFKAFTK RFSAEWNSLAVCI*KDHIRWMERHLIPCLLNKL *NDGLEKQASLTMVLLLGLLVTHTGLSLVCQ*SK YLLFCFY**FPNLVASFCIGIFGFQS*CLFYQT *PFISCPSLKLLIVLLPLQIFISIPTAFPCHP* TLSSPFRFWHCETPAGNLSDPPSPPRVHRPFIFH ELDPVSRW*YHGCCDTNSH*EVGGSPFSLDWYL FNYCFILSLGAMCQKSPQEFSEERTFYEAFSKV SFV*EYAHLNLQKEVSCVKPQSLKATDKLKKVSI LELGSFESFSLGT*PLVCGLHLKIGMNKMTKNV MGKNCPACPSQSHKVIFARAIFTYVFIVLDHKP LIYIMYL*GPKSTLCSF*LILRSGYGN*KSLSAK SSGNKCIDVNWFLGAPLPNSLGMTVEIQTRILV DILGLGQ*GLRTPQVVWERRRGVVGL*GEEEAG GLSADWLRSSGKSSKREREDLLRRMALPVTTF*L LFVLRFSQGKTCSPLVFHVHSVGGEHLGSG*TA VLLIAVPGRVRTNYKLMLVVKCSVFP*LSVFPE KKK*IFYSNTG