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Sequences

Sequence FGFR1.lAug05

CAAATTTGGAGGAATGAAATTCTCCAGCTAGAAGGCCCAAGAAAGTCTTATGGAAGAAACAGCTTCTTAAGGTGGGGTTCAGAGAAAAGGGAAGGGCTGG
CCTGTTGCAGAACAAGGAATGGCATGAAGAAAGTCTTGCACAGAGGCATGGATGTTGCTTCGAGCTGTGGCGCCCTATAGAAATAGAACATGAGCAGCTG
GTCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATTGCTTGAGCCCATGAGATGGAGATGAGCCTGGACAACATGGGTC
AGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGT
GCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGCTTGCCCAGATCTCCAGGAGGCTAA
GTGGTGCTCGGCCAGCTTCCACTCCATCACTCCCTTGCCATTTGGACTTGGTACTCGGCTTAGTGATTAGAGGCCCTGAACAGGTGGTGGTATCCCTGCT
CTGCTGGAGAGGAACCCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAACCAA
ACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTC
CAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTCCGTTATGCCACCTGG
AGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCTGGATG
TCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTA
CAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACT
GCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTA
TCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTA
TTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCT
GTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCAT
CACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTT
AGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTG
AAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCATCAACC
TGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGG
GCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTAT
CTGGCCTCCAAGAAGGTGTGGAACCTGAAGGCTCCCCTGGGTAATGCCAGGGTGGGAACAGAGCCCCCCTAGTCTTCCAGCCTGTGACTTATCA
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

QIWRNEILQLEGPRKSYGRNSFLRWGSEKREGL
ACCRTRNGMKKVLHRGMDVASSCGAL*K*NMSSW
SQWLMPVIPALWEAKAGGLLEPMRWR*AWTTWV
SLKRRIELTVEYPWRCGALSPTSNCRTGMWSWK
CLLFWAVLVTATLCTARPSPTLPEQACPDLQEAK
WCSASFHSITPLPFGLGTRLSD*RP*TGGGIPA
LLERNPDALPSSEDDDDDDDSSSEEKETDNTKP
NRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATW
SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD
VVERSPHRPILQAGLPANKTVALGSNVEFMCKVY
SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKT
AGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS
IGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIY
CTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRP
SRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAV
KMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPG
LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEY
LASKKVWNLKAPLGNARVGTEPP*SSSL*LI

Frame 1

KFGGMKFSS*KAQESLMEETAS*GGVQRKGKGW
PVAEQGMA*RKSCTEAWMLLRAVAPYRNRT*AA
GHSGSCL*SQHFGRPRQADCLSP*DGDEPGQHGS
V*KGGSSSLWSIHGDVEPCHQPLTAELGCGAGS
ASSSGLCWSQPHSAPLGRPRPCLNKLAQISRRL
SGARPASTPSLPCHLDLVLGLVIRGPEQVVVSLL
CWRGTQMLSPPRRMMMMMMTPLQRRKKQITPNQ
TVCP*LHIGHPQKRWKRNCMQCRLPRQ*SSNAL
PVGPQTPHCAG*KMAKNSNLTTELEATRSVMPPG
AS*WTLWCPLTRATTPALWRMSTAASTTHTSWM
SWSGPLTGPSCKQGCPPTKQWPWVATWSSCVRC
TVTRSRTSSG*STSR*MGARLAQTTCLMSRS*RL
LELIPPTKRWRCFT*EMSPLRTQGSIRAWRVTL
SDSPITLHG*PFWKPWKRGRQ**PRPCTWRSSS
IAQGPSSSPAWWGRSSSTR*RVVPRRVTSTARWL
CTSWPRASLCADR*QCLLTPVHP*TLGFFWFGH
HGSPPVGLPC*QGSLSMSFPKTLAGSCLGTDWS
*ANPWERAALGRWCWQRLSGWTRTNPTV*PKWL*
RC*SRTQQRKTCQT*SQKWR**R*SGSIRISST
CWGPARRMVPCMSSWSMPPRATCGSTCRPGGPQ
GWNTATTPATTQRSSSPPRTWCPAPTRWPEAWSI
WPPRRCGT*RLPWVMPGWEQSPPSLPACDLS

Frame 2

NLEE*NSPARRPKKVLWKKQLLKVGFREKGRAG
LLQNKEWHEESLAQRHGCCFELWRPIEIEHEQL
VTVAHACNPSTLGGQGRRIA*AHEMEMSLDNMG
QFEKEDRAHCGVSMEMWSLVTNL*LQNWDVELEV
PPLLGCAGHSHTLHR*AVPDLA*TSLPRSPGG*
VVLGQLPLHHSLAIWTWYSA**LEALNRWWYPC
SAGEEPRCSPLLGG******LLFRGERNR*HQTK
PYARSSILDIPRKDGKEIACSAGCQDSEVQMPF
QWDPKPHTALVEKWQRIQT*PQNWRLQGPLCHL
EHHNGLCGAL*QGQLHLHCGE*VRQHQPHIPAGC
RGAVPSPAHPASRVARQQNSGPG*QRGVHV*GV
Q*PAAAHPVAKAHRGEWEQDWPRQPALCPDLED
CWS*YHRQRDGGASLKKCLL*GRRGVYVLGG*LY
RTLPSLCMVDRSGSPGREAGSDDLAPVPGDHHL
LHRGLPHLLHGGVGHRLQDEEWYQEE*LPQPDG
CAQAGQEHPSAQTGNSVC*LQCIHELWGSSGSAI
TALLQWDSHASRGL*V*ASRRPSLGAASGQTGL
RQTPGRGLLWAGGVGRGYRAGQGQTQPCDQSGC
EDVEVGRNRERLVRPDLRNGDDEDDREA*EYHQP
AGGLHAGWSLVCHRGVCLQGQPAGVPAGPEAPR
AGILLQPQPQPRGAALLQGPGVLRLPGGPRHGV
SGLQEGVEPEGSPG*CQGGNRAPLVFQPVTY

Sequence FGFR1.gAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGATGGCAGCTGTGACCCGGGATTTCGGTGAGATGCTTCTGCACTCTGGCCGGGTCC
TGCCAGCCGAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGA
TGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCCC
GCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAATGTTTCAGATGCTCTCCCCTCCTCGGAGG
ATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAA
GATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAAT
GGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCA
ACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGG
GTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATC
GAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTC
ACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGA
AGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCG
GTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGG
TGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGA
GTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCA
GAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGA
TCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGA
GTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTC
TCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATG
TCCTGGTGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACT
GCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACT
CTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGC
TGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTC
CAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTC
TTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCC
CTCCCCAGACTCCACCGTCAGCTGTAACCCTCACCCACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCT
GCCTACCAGGGGCCTTCCTGTGTGGCCTGCCTTCACCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAG
ATCTTTGCTGCCAGCCACTTCATCCCCTCCCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAA
CAGGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTC
CTCAGGGCTACAGCAGTAGGGAGGTCAGTGCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATACT
AGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGG
GCTCTGTATATAGCTATGAAGAAAACACAAAGTGTATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGG
TAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGCTATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCT
ACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTAAACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTC
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQGWQL*PGISVRCFCTLAGS
CQPKPSPGEPLWKWSPSWSTPVTCCSFAVGCGT
MCRASTGCGTGCSWRKATAPASQGRRWRCRTPCP
QTPASMLA*PAAPRAVTPPTSPSMFQMLSPPRR
MMMMMMTPLQRRKKQITPNQTVCP*LHIGHPQK
RWKRNCMQCRLPRQ*SSNALPVGPQTPHCAG*KM
AKNSNLTTELEATRSVMPPGAS*WTLWCPLTRA
TTPALWRMSTAASTTHTSWMSWSGPLTGPSCKQ
GCPPTKQWPWVATWSSCVRCTVTRSRTSSG*STS
R*MGARLAQTTCLMSRS*RLLELIPPTKRWRCF
T*EMSPLRTQGSIRAWRVTLSDSPITLHG*PFW
KPWKRGRQ**PRPCTWRSSSIAQGPSSSPAWWGR
SSSTR*RVVPRRVTSTARWLCTSWPRASLCADR
CLLTPVHP*TLGFFWFGHHGSPPVGLPC*QGSL
SMSFPKTLAGSCLGTDWS*ANPWERAALGRWCWQ
RLSGWTRTNPTV*PKWL*RC*SRTQQRKTCQT*
SQKWR**R*SGSIRISSTCWGPARRMVPCMSSW
SMPPRATCGSTCRPGGPQGWNTATTPATTQRSSS
PPRTWCPAPTRWPEAWSIWPPRSAYTETWQPGM
SW*QRTM**R*QTLASHGTFTTSTTIKRQPTAD
CL*SGWHPRHYLTGSTPTRVMCGLSGCSCGRSSL
WAAPHTPVCLWRNFSSC*RRVTAWTSPVTAPTS
CT**CGTAGMQCPHRDPPSSSWWKTWTASWP*P
PTRSTWTCPCPWTSTPPAFPTPGALRAPQGRIPS
SLMSRCPRSPACPDTQPSLPMADSNAADCHPHA
LPRLHRQL*PSPTAPAGPTTCPSLSPFLLAGAG
CLPGAFLCGLPSPHSAHLSLHLLSTCW*EVQRGR
SLLPATSSPPRCWTNTPPCHQALPGGQGVGANE
QACK*ELPELSPVGLVCFAFTHKPLALWWQVPC
PQGYSSREVSASCLD*R*PLPQIGGASGLLIPIL
VCFADQMPGTRGW*GEGQVGGSVVALGPSPKLG
ALYIAMKKTQSV*I*VYIYMSF*KGRYQRFTHR
VRCSWWLGGISCYILKTKKKKKENVFKKVIYFLL
LLLFYFFKLCSKPIFSLGPSIKIAAA

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKDGSCDPGFR*DASALWPGP
ASRSPALGSPCGSGVLPGPPR*PAAASLSAAGR
CAEHQLAAGRGAAGGKQPHPHHRGGGGGAGLRA
RRLRPLCLRNQQPLGQ*HHLLLRQCFRCSPLLGG
******LLFRGERNR*HQTKPYARSSILDIPRK
DGKEIACSAGCQDSEVQMPFQWDPKPHTALVEK
WQRIQT*PQNWRLQGPLCHLEHHNGLCGAL*QGQ
LHLHCGE*VRQHQPHIPAGCRGAVPSPAHPASR
VARQQNSGPG*QRGVHV*GVQ*PAAAHPVAKAH
RGEWEQDWPRQPALCPDLEDCWS*YHRQRDGGAS
LKKCLL*GRRGVYVLGG*LYRTLPSLCMVDRSG
SPGREAGSDDLAPVPGDHHLLHRGLPHLLHGGV
GHRLQDEEWYQEE*LPQPDGCAQAGQEHPSAQTG
VC*LQCIHELWGSSGSAITALLQWDSHASRGL*
V*ASRRPSLGAASGQTGLRQTPGRGLLWAGGVG
RGYRAGQGQTQPCDQSGCEDVEVGRNRERLVRPD
LRNGDDEDDREA*EYHQPAGGLHAGWSLVCHRG
VCLQGQPAGVPAGPEAPRAGILLQPQPQPRGAA
LLQGPGVLRLPGGPRHGVSGLQEVHTPRPGSQEC
PGDRGQCDEDSRLWPRTGHSPHRLL*KDNQRPT
ACEVDGTRGII*PDLHPPE*CVVFRGAPVGDLH
SGRLPIPRCACGGTFQAAEGGSPHGQAQ*LHQRA
VHDDAGLLACSALTETHLQAAGGRPGPHRGLDL
QPGVPGPVHAPGPVLPQLSRHPELYVLLRGGFR
LLS*AAARGALPAPTPSPACQWRTQTPLTATHTP
SPDSTVSCNPHPQPLLGPPPVRPCPLSCWQEPA
AYQGPSCVACLHPTQLTSPSTSSPPAGERCKEA
DLCCQPLHPLPDVGPTPLPATRHCLEGREWEPMN
RHASESFLSFLLSVWSVLPSPISPSHSGGRCLV
LRATAVGRSVLRASIEGDLCPR*VVPVAY*FRY
*FALLTKCLVPEDGEAKARLGAVLWPWGPAPNWG
LCI*L*RKHKVYKSEYIFTCLFKRVVTRDLPIG
*DAPGGWEASVAIY*KQKRKKRKMFLKRSYIFC
YFCCFIFLNYVLNLFSV*VPQ*KLLLL

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TRMAAVTRDFGEMLLHSGRV
LPAEAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVP
ADSGLYACVTSSPSGSDTTYFSVNVSDALPSSE
DDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK
MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKN
GKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG
NYTCIVENEYGSINHTYQLDVVERSPHRPILQAG
LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI
EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVL
HLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS
VIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ
VSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLA
EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL
ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE
YASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARN
VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL
PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT
LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNE
LYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS
NQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSV
FSHEPLPEEPCLPRHPAQLANGGLKRR*LPPTR
PPQTPPSAVTLTHSPCWAHHLSVPVPFPAGRSRL
PTRGLPVWPAFTPLSSPLPPPPLHLLVRGAKRQ
IFAASHFIPSQMLDQHPSLPPGTAWRAGSGSQ*
TGMQVRAS*AFSCRFGLFCLHP*APRTLVAGALS
SGLQQ*GGQCFVPRLKVTSAPDRWCQWLINSDT
SLLC*PNAWYQRMVRRRPGWGQCCGPGAQPQTG
GSVYSYEENTKCINLSIYLHVFLKGSLPEIYPSG
KMLLVAGRHQLLYIKNKKEKKGKCF*KGHIFFA
TFAVLFF*IMF*TYFQFRSLNKNCCCF

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