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Sequences

Sequence FGFR1.nAug05

CCTCCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGG
AGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGG
CCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCA
AACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATG
CCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGAGCGGTCCCCTC
ACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCA
CATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGGTAATCATGGCACCAGTCTTC
GTGGGCCAGTCTACTGGGAAGGAGACCACTGTCTCGGGGGCTCAAGTTCCTGTGGGCAGGCTCAGTTGCCCCCGAATGGGATCATTCCTCACGCTTCAGG
CACACACACTCCATCTCAGTAGGGATCTAGCCACATCCCCCAGGACTAGTAACAGAGGTCACAAAGTGGAGGTGAGCTGGGAACAGAGGGCTGCAGGGAT
GGGTGGTGCTGGTCTGTAATAAGCTTTGAGAGCAACGTCACTGGGGCTTTGGGGTCAGCTACACAAGGAAGGCATTTGGACCCCTGCCTTTTCATTGCCC
GAAACCAGAGCCTTTCCACCAAGCGTTTCCCAGTCTTAGCCCTGTGTCCTGAGTTACGTACGATCTTTCTGGCAAATGGGGTGCATGATAAGAGCATCTC
TTACGAAGAGTTGGAAAAACAAATGCCATATATAAATTCTAAGCCATATGAGGACGAGGAGTAATGGCATTTTCTTCCTTTTTCCTCTCACTCCCAGACA
TTCATTGTCCCTGAATGCTCCATTAATCCAGGGAAGGTAATTGCCTAAATCTCCAGTGGATCTCGCAACAGGAAGGAACCAGAAGCTGGGAAAGTTGTTT
ACCTCTTTGTCCCAGAGTTAGACCTCATCCTCCCCTAGCTTAGCTGTCTCAGAGATATACTGGCCCTCCCTTCTCTTCTCTTTGCTGCTGGTGCTAAAAC
TGCTCTGTAGGTCATTGGCCACTGTCTCCACTCACAACCCCTGCTCCAGTCCTGGAGGGAGTGGGTTAAACACAAATAGAACATTCCATTTGAAGCAGTG
ATTCTTTTTTTTTTTTTTTTTTTTTAATCAAATGCTTTGGACTTTTGAAGTCCACTTGTTCTGTACTTGTAAAAGGGAAAGAAGGCCGGGCGCAGTGGCT
CACGCCTGTAATCCCAGCACTTTAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAT
TAGCTGTGCATAGTGGTTGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAGCTAACTGCTTGAACCCAGAAGGCAGAGGTTGCAGTGAGCTGAG
ATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGTGAGACTCTGCGTT
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Multiple exon skipping

Frame 0

PPTRARELARRRRLLRSV*KGGSSSLWSIHGDV
EPCHQPLTAELGCGAGSASSSGLCWSQPHSAPLG
RPRPCLNKMLSPPRRMMMMMMTPLQRRKKQITP
NQTVCP*LHIGHPQKRWKRNCMQCRLPRQ*SSN
ALPVGPQTPHCAG*KMAKNSNLTTELEATRAVPS
PAHPASRVARQQNSGPG*QRGVHV*GVQ*PAAA
HPVAKAHRGEWEQDWPRQPALCPDLEGNHGTSL
RGPVYWEGDHCLGGSSSCGQAQLPPNGIIPHASG
THTPSQ*GSSHIPQD**QRSQSGGELGTEGCRD
GWCWSVISFESNVTGALGSATQGRHLDPCLFIA
RNQSLSTKRFPVLALCPELRTIFLANGVHDKSIS
YEELEKQMPYINSKPYEDEE*WHFLPFSSHSQT
FIVPECSINPGKVIA*ISSGSRNRKEPEAGKVV
YLFVPELDLILP*LSCLRDILALPSLLFAAGAKT
AL*VIGHCLHSQPLLQSWREWVKHK*NIPFEAV
ILFFFFFF*SNALDF*SPLVLYL*KGKKAGRSG
SRL*SQHFRSLEVRSLRPARPTW*NPISTKNTKI
SCA*WLAPVVPATQEAEAS*LLEPRRQRLQ*AE
ITPLHSSLGDRVSETLR

Frame 1

LQLALGSWRGGGGSSGQFEKEDRAHCGVSMEMW
SLVTNL*LQNWDVELEVPPLLGCAGHSHTLHR*
AVPDLA*TRCSPLLGG******LLFRGERNR*HQ
TKPYARSSILDIPRKDGKEIACSAGCQDSEVQM
PFQWDPKPHTALVEKWQRIQT*PQNWRLQERSP
HRPILQAGLPANKTVALGSNVEFMCKVYSDPQPH
IQWLKHIEVNGSKIGPDNLPYVQILKVIMAPVF
VGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQ
AHTLHLSRDLATSPRTSNRGHKVEVSWEQRAAGM
GGAGL**ALRATSLGLWGQLHKEGIWTPAFSLP
ETRAFPPSVSQS*PCVLSYVRSFWQMGCMIRAS
LTKSWKNKCHI*ILSHMRTRSNGIFFLFPLTPRH
SLSLNAPLIQGR*LPKSPVDLATGRNQKLGKLF
TSLSQS*TSSSPSLAVSEIYWPSLLFSLLLVLK
LLCRSLATVSTHNPCSSPGGSGLNTNRTFHLKQ*
FFFFFFFFNQMLWTFEVHLFCTCKRERRPGAVA
HACNPSTLDHLRSGV*DQPGQHGETPSLLKIQK
LAVHSGWHL*SQLLRRLRQANCLNPEGRGCSELR
SRHCTPAWVTE*VRLCV

Frame 2

SNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCG
ALSPTSNCRTGMWSWKCLLFWAVLVTATLCTAR
PSPTLPEQDALPSSEDDDDDDDSSSEEKETDNT
KPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKC
PSSGTPNPTLRWLKNGKEFKPDHRIGGYKSGPL
TGPSCKQGCPPTKQWPWVATWSSCVRCTVTRSR
TSSG*STSR*MGARLAQTTCLMSRS*R*SWHQSS
WASLLGRRPLSRGLKFLWAGSVAPEWDHSSRFR
HTHSISVGI*PHPPGLVTEVTKWR*AGNRGLQG
WVVLVCNKL*EQRHWGFGVSYTRKAFGPLPFHCP
KPEPFHQAFPSLSPVS*VTYDLSGKWGA**EHL
LRRVGKTNAIYKF*AI*GRGVMAFSSFFLSLPD
IHCP*MLH*SREGNCLNLQWISQQEGTRSWESCL
PLCPRVRPHPPLA*LSQRYTGPPFSSLCCWC*N
CSVGHWPLSPLTTPAPVLEGVG*TQIEHSI*SS
DSFFFFFFLIKCFGLLKSTCSVLVKGKEGRAQWL
TPVIPAL*IT*GQEFETSPANMVKPHLY*KYKN
*LCIVVGTCSPSYSGG*GKLTA*TQKAEVAVS*
DHATALQPG*QSE*DSA

Sequence FGFR1.kAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAG
AAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAG
TGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAA
GGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAAC
CACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGG
AGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTA
TGTCCAGATCTTGAAGGTAATCATGGCACCAGTCTTCGTGGGCCAGTCTACTGGGAAGGAGACCACTGTCTCGGGGGCTCAAGTTCCTGTGGGCAGGCTC
AGTTGCCCCCGAATGGGATCATTCCTCACGCTTCAGGCACACACACTCCATCTCAGTAGGGATCTAGCCACATCCCCCAGGACTAGTAACAGAGGTCACA
AAGTGGAGGTGAGCTGGGAACAGAGGGCTGCAGGGATGGGTGGTGCTGGTCTGTAATAAGCTTTGAGAGCAACGTCACTGGGGCTTTGGGGTCAGCTACA
CAAGGAAGGCATTTGGACCCCTGCCTTTTCATTGCCCGAAACCAGAGCCTTTCCACCAAGCGTTTCCCAGTCTTAGCCCTGTGTCCTGAGTTACGTACGA
TCTTTCTGGCAAATGGGGTGCATGATAAGAGCATCTCTTACGAAGAGTTGGAAAAACAAATGCCATATATAAATTCTAAGCCATATGAGGACGAGGAGTA
ATGGCATTTTCTTCCTTTTTCCTCTCACTCCCAGACATTCATTGTCCCTGAATGCTCCATTAATCCAGGGAAGGTAATTGCCTAAATCTCCAGTGGATCT
CGCAACAGGAAGGAACCAGAAGCTGGGAAAGTTGTTTACCTCTTTGTCCCAGAGTTAGACCTCATCCTCCCCTAGCTTAGCTGTCTCAGAGATATACTGG
CCCTCCCTTCTCTTCTCTTTGCTGCTGGTGCTAAAACTGCTCTGTAGGTCATTGGCCACTGTCTCCACTCACAACCCCTGCTCCAGTCCTGGAGGGAGTG
GGTTAAACACAAATAGAACATTCCATTTGAAGCAGTGATTCTTTTTTTTTTTTTTTTTTTTTAATCAAATGCTTTGGACTTTTGAAGTCCACTTGTTCTG
TACTTGTAAAAGGGAAAGAAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAA
CATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGTGCATAGTGGTTGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAGCTAACT
GCTTGAACCCAGAAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGTGAGACTCTGCGTT
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQDALPSSEDDDDDDDSSSEE
KETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKT
VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYK
VRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNV
EFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPY
VQILKVIMAPVFVGQSTGKETTVSGAQVPVGRL
SCPRMGSFLTLQAHTLHLSRDLATSPRTSNRGH
KVEVSWEQRAAGMGGAGL**ALRATSLGLWGQLH
KEGIWTPAFSLPETRAFPPSVSQS*PCVLSYVR
SFWQMGCMIRASLTKSWKNKCHI*ILSHMRTRS
NGIFFLFPLTPRHSLSLNAPLIQGR*LPKSPVDL
ATGRNQKLGKLFTSLSQS*TSSSPSLAVSEIYW
PSLLFSLLLVLKLLCRSLATVSTHNPCSSPGGS
GLNTNRTFHLKQ*FFFFFFFFNQMLWTFEVHLFC
TCKRERRPGAVAHACNPSTLDHLRSGV*DQPGQ
HGETPSLLKIQKLAVHSGWHL*SQLLRRLRQAN
CLNPEGRGCSELRSRHCTPAWVTE*VRLCV

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKMLSPPRRMMMMMMTPLQRR
KKQITPNQTP*LHIGHPQKRWKRNCMQCRLPRQ
*SSNALPVGPQTPHCAG*KMAKNSNLTTELEAT
RSVMPPGAS*WTLWCPLTRATTPALWRMSTAAST
THTSWMSWSGPLTGPSCKQGCPPTKQWPWVATW
SSCVRCTVTRSRTSSG*STSR*MGARLAQTTCL
MSRS*R*SWHQSSWASLLGRRPLSRGLKFLWAGS
VAPEWDHSSRFRHTHSISVGI*PHPPGLVTEVT
KWR*AGNRGLQGWVVLVCNKL*EQRHWGFGVSY
TRKAFGPLPFHCPKPEPFHQAFPSLSPVS*VTYD
LSGKWGA**EHLLRRVGKTNAIYKF*AI*GRGV
MAFSSFFLSLPDIHCP*MLH*SREGNCLNLQWI
SQQEGTRSWESCLPLCPRVRPHPPLA*LSQRYTG
PPFSSLCCWC*NCSVGHWPLSPLTTPAPVLEGV
G*TQIEHSI*SSDSFFFFFFLIKCFGLLKSTCS
VLVKGKEGRAQWLTPVIPAL*IT*GQEFETSPAN
MVKPHLY*KYKN*LCIVVGTCSPSYSGG*GKLT
A*TQKAEVAVS*DHATALQPG*QSE*DSA

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TRCSPLLGG******LLFRG
ERNR*HQTKPRSSILDIPRKDGKEIACSAGCQDS
EVQMPFQWDPKPHTALVEKWQRIQT*PQNWRLQ
GPLCHLEHHNGLCGAL*QGQLHLHCGE*VRQHQ
PHIPAGCRGAVPSPAHPASRVARQQNSGPG*QRG
VHV*GVQ*PAAAHPVAKAHRGEWEQDWPRQPAL
CPDLEGNHGTSLRGPVYWEGDHCLGGSSSCGQA
QLPPNGIIPHASGTHTPSQ*GSSHIPQD**QRSQ
SGGELGTEGCRDGWCWSVISFESNVTGALGSAT
QGRHLDPCLFIARNQSLSTKRFPVLALCPELRT
IFLANGVHDKSISYEELEKQMPYINSKPYEDEE*
WHFLPFSSHSQTFIVPECSINPGKVIA*ISSGS
RNRKEPEAGKVVYLFVPELDLILP*LSCLRDIL
ALPSLLFAAGAKTAL*VIGHCLHSQPLLQSWREW
VKHK*NIPFEAVILFFFFFF*SNALDF*SPLVL
YL*KGKKAGRSGSRL*SQHFRSLEVRSLRPARP
TW*NPISTKNTKISCA*WLAPVVPATQEAEAS*L
LEPRRQRLQ*AEITPLHSSLGDRVSETLR

Sequence FGFR1.jAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAG
AAAGAAACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCA
AGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGG
CTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGC
ATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCA
ACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCT
GCCTTATGTCCAGATCTTGAAGGTAATCATGGCACCAGTCTTCGTGGGCCAGTCTACTGGGAAGGAGACCACTGTCTCGGGGGCTCAAGTTCCTGTGGGC
AGGCTCAGTTGCCCCCGAATGGGATCATTCCTCACGCTTCAGGCACACACACTCCATCTCAGTAGGGATCTAGCCACATCCCCCAGGACTAGTAACAGAG
GTCACAAAGTGGAGGTGAGCTGGGAACAGAGGGCTGCAGGGATGGGTGGTGCTGGTCTGTAATAAGCTTTGAGAGCAACGTCACTGGGGCTTTGGGGTCA
GCTACACAAGGAAGGCATTTGGACCCCTGCCTTTTCATTGCCCGAAACCAGAGCCTTTCCACCAAGCGTTTCCCAGTCTTAGCCCTGTGTCCTGAGTTAC
GTACGATCTTTCTGGCAAATGGGGTGCATGATAAGAGCATCTCTTACGAAGAGTTGGAAAAACAAATGCCATATATAAATTCTAAGCCATATGAGGACGA
GGAGTAATGGCATTTTCTTCCTTTTTCCTCTCACTCCCAGACATTCATTGTCCCTGAATGCTCCATTAATCCAGGGAAGGTAATTGCCTAAATCTCCAGT
GGATCTCGCAACAGGAAGGAACCAGAAGCTGGGAAAGTTGTTTACCTCTTTGTCCCAGAGTTAGACCTCATCCTCCCCTAGCTTAGCTGTCTCAGAGATA
TACTGGCCCTCCCTTCTCTTCTCTTTGCTGCTGGTGCTAAAACTGCTCTGTAGGTCATTGGCCACTGTCTCCACTCACAACCCCTGCTCCAGTCCTGGAG
GGAGTGGGTTAAACACAAATAGAACATTCCATTTGAAGCAGTGATTCTTTTTTTTTTTTTTTTTTTTTAATCAAATGCTTTGGACTTTTGAAGTCCACTT
GTTCTGTACTTGTAAAAGGGAAAGAAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCC
GGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGTGCATAGTGGTTGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAG
CTAACTGCTTGAACCCAGAAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGTGAGACTCTGCGTT
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQDALPSSEDDDDDDDSSSEE
KETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG
YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS
INHTYQLDVVERSPHRPILQAGLPANKTVALGS
NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNL
PYVQILKVIMAPVFVGQSTGKETTVSGAQVPVG
RLSCPRMGSFLTLQAHTLHLSRDLATSPRTSNR
GHKVEVSWEQRAAGMGGAGL**ALRATSLGLWGQ
LHKEGIWTPAFSLPETRAFPPSVSQS*PCVLSY
VRSFWQMGCMIRASLTKSWKNKCHI*ILSHMRT
RSNGIFFLFPLTPRHSLSLNAPLIQGR*LPKSPV
DLATGRNQKLGKLFTSLSQS*TSSSPSLAVSEI
YWPSLLFSLLLVLKLLCRSLATVSTHNPCSSPG
GSGLNTNRTFHLKQ*FFFFFFFFNQMLWTFEVHL
FCTCKRERRPGAVAHACNPSTLDHLRSGV*DQP
GQHGETPSLLKIQKLAVHSGWHL*SQLLRRLRQ
ANCLNPEGRGCSELRSRHCTPAWVTE*VRLCV

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKMLSPPRRMMMMMMTPLQRR
KKQITPNQTVCP*LHIGHPQKRWKRNCMQCRLP
RQ*SSNALPVGPQTPHCAG*KMAKNSNLTTELE
ATRSVMPPGAS*WTLWCPLTRATTPALWRMSTAA
STTHTSWMSWSGPLTGPSCKQGCPPTKQWPWVA
TWSSCVRCTVTRSRTSSG*STSR*MGARLAQTT
CLMSRS*R*SWHQSSWASLLGRRPLSRGLKFLWA
GSVAPEWDHSSRFRHTHSISVGI*PHPPGLVTE
VTKWR*AGNRGLQGWVVLVCNKL*EQRHWGFGV
SYTRKAFGPLPFHCPKPEPFHQAFPSLSPVS*VT
YDLSGKWGA**EHLLRRVGKTNAIYKF*AI*GR
GVMAFSSFFLSLPDIHCP*MLH*SREGNCLNLQ
WISQQEGTRSWESCLPLCPRVRPHPPLA*LSQRY
TGPPFSSLCCWC*NCSVGHWPLSPLTTPAPVLE
GVG*TQIEHSI*SSDSFFFFFFLIKCFGLLKST
CSVLVKGKEGRAQWLTPVIPAL*IT*GQEFETSP
ANMVKPHLY*KYKN*LCIVVGTCSPSYSGG*GK
LTA*TQKAEVAVS*DHATALQPG*QSE*DSA

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TRCSPLLGG******LLFRG
ERNR*HQTKPYARSSILDIPRKDGKEIACSAGCQ
DSEVQMPFQWDPKPHTALVEKWQRIQT*PQNWR
LQGPLCHLEHHNGLCGAL*QGQLHLHCGE*VRQ
HQPHIPAGCRGAVPSPAHPASRVARQQNSGPG*Q
RGVHV*GVQ*PAAAHPVAKAHRGEWEQDWPRQP
ALCPDLEGNHGTSLRGPVYWEGDHCLGGSSSCG
QAQLPPNGIIPHASGTHTPSQ*GSSHIPQD**QR
SQSGGELGTEGCRDGWCWSVISFESNVTGALGS
ATQGRHLDPCLFIARNQSLSTKRFPVLALCPEL
RTIFLANGVHDKSISYEELEKQMPYINSKPYEDE
E*WHFLPFSSHSQTFIVPECSINPGKVIA*ISS
GSRNRKEPEAGKVVYLFVPELDLILP*LSCLRD
ILALPSLLFAAGAKTAL*VIGHCLHSQPLLQSWR
EWVKHK*NIPFEAVILFFFFFF*SNALDF*SPL
VLYL*KGKKAGRSGSRL*SQHFRSLEVRSLRPA
RPTW*NPISTKNTKISCA*WLAPVVPATQEAEAS
*LLEPRRQRLQ*AEITPLHSSLGDRVSETLR

Sequence FGFR1.eAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAG
AAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAG
TGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAA
GGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAAC
CACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGG
AGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTA
TGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACG
TGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGT
ACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGA
CTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGG
GTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGC
CTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCG
TGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAG
CATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGC
AGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGT
GGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACAGAGGACAATGTGATGAAGATAGCA
GACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTG
ACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGA
GGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTG
CCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGG
ACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCT
GCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACCCTCACC
CACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCTGTGTGGCCTGCCTTCA
CCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCACTTCATCCCCTCCCAGAT
GTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAACAGGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCC
TGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCAGTGCTTCG
TGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATACTAGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAG
GATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACAAAGTGT
ATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGC
TATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTA
AACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTC
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQDALPSSEDDDDDDDSSSEE
KETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKT
VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYK
VRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNV
EFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPY
VQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT
CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPL
YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSD
FHSQMAVHKLAKSIPLRRQVTVSADSSASMNSG
VLLVRPSRLSSSGTPMLAGVSEYELPEDPRWEL
PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR
VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYL
QARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV
ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA
DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF
DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE
ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV
PSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPL
DQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCL
PRHPAQLANGGLKRR*LPPTRPPQTPPSAVTLT
HSPCWAHHLSVPVPFPAGRSRLPTRGLPVWPAF
TPLSSPLPPPPLHLLVRGAKRQIFAASHFIPSQM
LDQHPSLPPGTAWRAGSGSQ*TGMQVRAS*AFS
CRFGLFCLHP*APRTLVAGALSSGLQQ*GGQCF
VPRLKVTSAPDRWCQWLINSDTSLLC*PNAWYQR
MVRRRPGWGQCCGPGAQPQTGGSVYSYEENTKC
INLSIYLHVFLKGSLPEIYPSGKMLLVAGRHQL
LYIKNKKEKKGKCF*KGHIFFATFAVLFF*IMF*
TYFQFRSLNKNCCCF

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKMLSPPRRMMMMMMTPLQRR
KKQITPNQTP*LHIGHPQKRWKRNCMQCRLPRQ
*SSNALPVGPQTPHCAG*KMAKNSNLTTELEAT
RSVMPPGAS*WTLWCPLTRATTPALWRMSTAAST
THTSWMSWSGPLTGPSCKQGCPPTKQWPWVATW
SSCVRCTVTRSRTSSG*STSR*MGARLAQTTCL
MSRS*RLLELIPPTKRWRCFT*EMSPLRTQGSIR
AWRVTLSDSPITLHG*PFWKPWKRGRQ**PRPC
TWRSSSIAQGPSSSPAWWGRSSSTR*RVVPRRV
TSTARWLCTSWPRASLCADR*QCLLTPVHP*TLG
FFWFGHHGSPPVGLPC*QGSLSMSFPKTLAGSC
LGTDWS*ANPWERAALGRWCWQRLSGWTRTNPT
V*PKWL*RC*SRTQQRKTCQT*SQKWR**R*SGS
IRISSTCWGPARRMVPCMSSWSMPPRATCGSTC
RPGGPQGWNTATTPATTQRSSSPPRTWCPAPTR
WPEAWSIWPPRSAYTETWQPGMSW*QRTM**R*Q
TLASHGTFTTSTTIKRQPTADCL*SGWHPRHYL
TGSTPTRVMCGLSGCSCGRSSLWAAPHTPVCLW
RNFSSC*RRVTAWTSPVTAPTSCT**CGTAGMQC
PHRDPPSSSWWKTWTASWP*PPTRSTWTCPCPW
TSTPPAFPTPGALRAPQGRIPSSLMSRCPRSPA
CPDTQPSLPMADSNAADCHPHALPRLHRQL*PSP
TAPAGPTTCPSLSPFLLAGAGCLPGAFLCGLPS
PHSAHLSLHLLSTCW*EVQRGRSLLPATSSPPR
CWTNTPPCHQALPGGQGVGANEQACK*ELPELSP
VGLVCFAFTHKPLALWWQVPCPQGYSSREVSAS
CLD*R*PLPQIGGASGLLIPILVCFADQMPGTR
GW*GEGQVGGSVVALGPSPKLGALYIAMKKTQSV
*I*VYIYMSF*KGRYQRFTHRVRCSWWLGGISC
YILKTKKKKKENVFKKVIYFLLLLLFYFFKLCS
KPIFSLGPSIKIAAA

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TRCSPLLGG******LLFRG
ERNR*HQTKPRSSILDIPRKDGKEIACSAGCQDS
EVQMPFQWDPKPHTALVEKWQRIQT*PQNWRLQ
GPLCHLEHHNGLCGAL*QGQLHLHCGE*VRQHQ
PHIPAGCRGAVPSPAHPASRVARQQNSGPG*QRG
VHV*GVQ*PAAAHPVAKAHRGEWEQDWPRQPAL
CPDLEDCWS*YHRQRDGGASLKKCLL*GRRGVY
VLGG*LYRTLPSLCMVDRSGSPGREAGSDDLAPV
PGDHHLLHRGLPHLLHGGVGHRLQDEEWYQEE*
LPQPDGCAQAGQEHPSAQTGNSVC*LQCIHELW
GSSGSAITALLQWDSHASRGL*V*ASRRPSLGAA
SGQTGLRQTPGRGLLWAGGVGRGYRAGQGQTQP
CDQSGCEDVEVGRNRERLVRPDLRNGDDEDDRE
A*EYHQPAGGLHAGWSLVCHRGVCLQGQPAGVPA
GPEAPRAGILLQPQPQPRGAALLQGPGVLRLPG
GPRHGVSGLQEVHTPRPGSQECPGDRGQCDEDS
RLWPRTGHSPHRLL*KDNQRPTACEVDGTRGII*
PDLHPPE*CVVFRGAPVGDLHSGRLPIPRCACG
GTFQAAEGGSPHGQAQ*LHQRAVHDDAGLLACS
ALTETHLQAAGGRPGPHRGLDLQPGVPGPVHAPG
PVLPQLSRHPELYVLLRGGFRLLS*AAARGALP
APTPSPACQWRTQTPLTATHTPSPDSTVSCNPH
PQPLLGPPPVRPCPLSCWQEPAAYQGPSCVACLH
PTQLTSPSTSSPPAGERCKEADLCCQPLHPLPD
VGPTPLPATRHCLEGREWEPMNRHASESFLSFL
LSVWSVLPSPISPSHSGGRCLVLRATAVGRSVLR
ASIEGDLCPR*VVPVAY*FRY*FALLTKCLVPE
DGEAKARLGAVLWPWGPAPNWGLCI*L*RKHKV
YKSEYIFTCLFKRVVTRDLPIG*DAPGGWEASVA
IY*KQKRKKRKMFLKRSYIFCYFCCFIFLNYVL
NLFSV*VPQ*KLLLL

Sequence FGFR1.dAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAG
AAAGAAACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCA
AGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGG
CTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGC
ATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCA
ACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCT
GCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAG
TATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGC
CCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAA
GAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAAC
TCTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGG
AGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACC
CAACCGTGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATC
GGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGT
ACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTA
CCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACAGAGGACAATGTGATGAAG
ATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCAT
TATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCC
TGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCAT
GCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGC
CCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCC
CTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACC
CTCACCCACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCTGTGTGGCCTG
CCTTCACCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCACTTCATCCCCTC
CCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAACAGGCATGCAAGTGAGAGCTTCCTGAGCT
TTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCAGT
GCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATACTAGTTTGCTTTGCTGACCAAATGCCTGGTA
CCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACA
AAGTGTATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATC
AGTTGCTATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTAT
GTTCTAAACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTC
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQDALPSSEDDDDDDDSSSEE
KETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG
YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS
INHTYQLDVVERSPHRPILQAGLPANKTVALGS
NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNL
PYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE
YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTS
PLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKK
SDFHSQMAVHKLAKSIPLRRQVTVSADSSASMN
SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRW
ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMI
GKHKNIINLLGACTQDGPLYVIVEYASKGNLRE
YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAY
QVARGMEYLASKKCIHRDLAARNVLVTEDNVMK
IADFGLARDIHHIDYYKKTTNGRLPVKWMAPEA
LFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP
VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH
AVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM
PLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP
CLPRHPAQLANGGLKRR*LPPTRPPQTPPSAVT
LTHSPCWAHHLSVPVPFPAGRSRLPTRGLPVWP
AFTPLSSPLPPPPLHLLVRGAKRQIFAASHFIPS
QMLDQHPSLPPGTAWRAGSGSQ*TGMQVRAS*A
FSCRFGLFCLHP*APRTLVAGALSSGLQQ*GGQ
CFVPRLKVTSAPDRWCQWLINSDTSLLC*PNAWY
QRMVRRRPGWGQCCGPGAQPQTGGSVYSYEENT
KCINLSIYLHVFLKGSLPEIYPSGKMLLVAGRH
QLLYIKNKKEKKGKCF*KGHIFFATFAVLFF*IM
F*TYFQFRSLNKNCCCF

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKMLSPPRRMMMMMMTPLQRR
KKQITPNQTVCP*LHIGHPQKRWKRNCMQCRLP
RQ*SSNALPVGPQTPHCAG*KMAKNSNLTTELE
ATRSVMPPGAS*WTLWCPLTRATTPALWRMSTAA
STTHTSWMSWSGPLTGPSCKQGCPPTKQWPWVA
TWSSCVRCTVTRSRTSSG*STSR*MGARLAQTT
CLMSRS*RLLELIPPTKRWRCFT*EMSPLRTQGS
IRAWRVTLSDSPITLHG*PFWKPWKRGRQ**PR
PCTWRSSSIAQGPSSSPAWWGRSSSTR*RVVPR
RVTSTARWLCTSWPRASLCADR*QCLLTPVHP*T
LGFFWFGHHGSPPVGLPC*QGSLSMSFPKTLAG
SCLGTDWS*ANPWERAALGRWCWQRLSGWTRTN
PTV*PKWL*RC*SRTQQRKTCQT*SQKWR**R*S
GSIRISSTCWGPARRMVPCMSSWSMPPRATCGS
TCRPGGPQGWNTATTPATTQRSSSPPRTWCPAP
TRWPEAWSIWPPRSAYTETWQPGMSW*QRTM**R
*QTLASHGTFTTSTTIKRQPTADCL*SGWHPRH
YLTGSTPTRVMCGLSGCSCGRSSLWAAPHTPVC
LWRNFSSC*RRVTAWTSPVTAPTSCT**CGTAGM
QCPHRDPPSSSWWKTWTASWP*PPTRSTWTCPC
PWTSTPPAFPTPGALRAPQGRIPSSLMSRCPRS
PACPDTQPSLPMADSNAADCHPHALPRLHRQL*P
SPTAPAGPTTCPSLSPFLLAGAGCLPGAFLCGL
PSPHSAHLSLHLLSTCW*EVQRGRSLLPATSSP
PRCWTNTPPCHQALPGGQGVGANEQACK*ELPEL
SPVGLVCFAFTHKPLALWWQVPCPQGYSSREVS
ASCLD*R*PLPQIGGASGLLIPILVCFADQMPG
TRGW*GEGQVGGSVVALGPSPKLGALYIAMKKTQ
SV*I*VYIYMSF*KGRYQRFTHRVRCSWWLGGI
SCYILKTKKKKKENVFKKVIYFLLLLLFYFFKL
CSKPIFSLGPSIKIAAA

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TRCSPLLGG******LLFRG
ERNR*HQTKPYARSSILDIPRKDGKEIACSAGCQ
DSEVQMPFQWDPKPHTALVEKWQRIQT*PQNWR
LQGPLCHLEHHNGLCGAL*QGQLHLHCGE*VRQ
HQPHIPAGCRGAVPSPAHPASRVARQQNSGPG*Q
RGVHV*GVQ*PAAAHPVAKAHRGEWEQDWPRQP
ALCPDLEDCWS*YHRQRDGGASLKKCLL*GRRG
VYVLGG*LYRTLPSLCMVDRSGSPGREAGSDDLA
PVPGDHHLLHRGLPHLLHGGVGHRLQDEEWYQE
E*LPQPDGCAQAGQEHPSAQTGNSVC*LQCIHE
LWGSSGSAITALLQWDSHASRGL*V*ASRRPSLG
AASGQTGLRQTPGRGLLWAGGVGRGYRAGQGQT
QPCDQSGCEDVEVGRNRERLVRPDLRNGDDEDD
REA*EYHQPAGGLHAGWSLVCHRGVCLQGQPAGV
PAGPEAPRAGILLQPQPQPRGAALLQGPGVLRL
PGGPRHGVSGLQEVHTPRPGSQECPGDRGQCDE
DSRLWPRTGHSPHRLL*KDNQRPTACEVDGTRGI
I*PDLHPPE*CVVFRGAPVGDLHSGRLPIPRCA
CGGTFQAAEGGSPHGQAQ*LHQRAVHDDAGLLA
CSALTETHLQAAGGRPGPHRGLDLQPGVPGPVHA
PGPVLPQLSRHPELYVLLRGGFRLLS*AAARGA
LPAPTPSPACQWRTQTPLTATHTPSPDSTVSCN
PHPQPLLGPPPVRPCPLSCWQEPAAYQGPSCVAC
LHPTQLTSPSTSSPPAGERCKEADLCCQPLHPL
PDVGPTPLPATRHCLEGREWEPMNRHASESFLS
FLLSVWSVLPSPISPSHSGGRCLVLRATAVGRSV
LRASIEGDLCPR*VVPVAY*FRY*FALLTKCLV
PEDGEAKARLGAVLWPWGPAPNWGLCI*L*RKH
KVYKSEYIFTCLFKRVVTRDLPIG*DAPGGWEAS
VAIY*KQKRKKRKMFLKRSYIFCYFCCFIFLNY
VLNLFSV*VPQ*KLLLL

Sequence FGFR1.mAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGAC
CTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAG
GGGAGGAGGTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGT
CAATGTTTCAGCTTGCCCAGATCTCCAGGAGGCTAAGTGGTGCTCGGCCAGCTTCCACTCCATCACTCCCTTGCCATTTGGACTTGGTACTCGGCTTAGT
GATTAGAGGCCCTGAACAGGTGGTGGTATCCCTGCTCTGCTGGAGAGGAACCCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCT
CTTCAGAGGAGAAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGC
TGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATT
GGAGGCTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCT
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQAQPWGAPVEVESFLVHPGD
LLQLRCRLRDDVQSINWLRDGVQLAESNRTRIT
GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSV
NVSACPDLQEAKWCSASFHSITPLPFGLGTRLS
D*RP*TGGGIPALLERNPDALPSSEDDDDDDDS
SSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPA
AKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI
GGYKVRYATWSIIMDSVVPSDKGNYT

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKPSPGEPLWKWSPSWSTPVT
CCSFAVGCGTMCRASTGCGTGCSWRKATAPASQ
GRRWRCRTPCPQTPASMLA*PAAPRAVTPPTSP
SMFQLAQISRRLSGARPASTPSLPCHLDLVLGLV
IRGPEQVVVSLLCWRGTQMLSPPRRMMMMMMTP
LQRRKKQITPNQTP*LHIGHPQKRWKRNCMQCR
LPRQ*SSNALPVGPQTPHCAG*KMAKNSNLTTEL
EATRSVMPPGAS*WTLWCPLTRATTP

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TSPALGSPCGSGVLPGPPR*
PAAASLSAAGRCAEHQLAAGRGAAGGKQPHPHHR
GGGGGAGLRARRLRPLCLRNQQPLGQ*HHLLLR
QCFSLPRSPGG*VVLGQLPLHHSLAIWTWYSA*
*LEALNRWWYPCSAGEEPRCSPLLGG******LL
FRGERNR*HQTKPRSSILDIPRKDGKEIACSAG
CQDSEVQMPFQWDPKPHTALVEKWQRIQT*PQN
WRLQGPLCHLEHHNGLCGAL*QGQLH

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