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Sequences

Sequence FGFR1.lAug05

CAAATTTGGAGGAATGAAATTCTCCAGCTAGAAGGCCCAAGAAAGTCTTATGGAAGAAACAGCTTCTTAAGGTGGGGTTCAGAGAAAAGGGAAGGGCTGG
CCTGTTGCAGAACAAGGAATGGCATGAAGAAAGTCTTGCACAGAGGCATGGATGTTGCTTCGAGCTGTGGCGCCCTATAGAAATAGAACATGAGCAGCTG
GTCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATTGCTTGAGCCCATGAGATGGAGATGAGCCTGGACAACATGGGTC
AGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGT
GCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGCTTGCCCAGATCTCCAGGAGGCTAA
GTGGTGCTCGGCCAGCTTCCACTCCATCACTCCCTTGCCATTTGGACTTGGTACTCGGCTTAGTGATTAGAGGCCCTGAACAGGTGGTGGTATCCCTGCT
CTGCTGGAGAGGAACCCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAACCAA
ACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTC
CAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTCCGTTATGCCACCTGG
AGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCTGGATG
TCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTA
CAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACT
GCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTA
TCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTA
TTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCT
GTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCAT
CACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTT
AGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTG
AAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCATCAACC
TGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGG
GCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTAT
CTGGCCTCCAAGAAGGTGTGGAACCTGAAGGCTCCCCTGGGTAATGCCAGGGTGGGAACAGAGCCCCCCTAGTCTTCCAGCCTGTGACTTATCA
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Single exon skipping

Frame 0

QIWRNEILQLEGPRKSYGRNSFLRWGSEKREGL
ACCRTRNGMKKVLHRGMDVASSCGAL*K*NMSSW
SQWLMPVIPALWEAKAGGLLEPMRWR*AWTTWV
SLKRRIELTVEYPWRCGALSPTSNCRTGMWSWK
CLLFWAVLVTATLCTARPSPTLPEQACPDLQEAK
WCSASFHSITPLPFGLGTRLSD*RP*TGGGIPA
LLERNPDALPSSEDDDDDDDSSSEEKETDNTKP
NRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATW
SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD
VVERSPHRPILQAGLPANKTVALGSNVEFMCKVY
SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKT
AGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS
IGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIY
CTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRP
SRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAV
KMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPG
LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEY
LASKKVWNLKAPLGNARVGTEPP*SSSL*LI

Frame 1

KFGGMKFSS*KAQESLMEETAS*GGVQRKGKGW
PVAEQGMA*RKSCTEAWMLLRAVAPYRNRT*AA
GHSGSCL*SQHFGRPRQADCLSP*DGDEPGQHGS
V*KGGSSSLWSIHGDVEPCHQPLTAELGCGAGS
ASSSGLCWSQPHSAPLGRPRPCLNKLAQISRRL
SGARPASTPSLPCHLDLVLGLVIRGPEQVVVSLL
CWRGTQMLSPPRRMMMMMMTPLQRRKKQITPNQ
TVCP*LHIGHPQKRWKRNCMQCRLPRQ*SSNAL
PVGPQTPHCAG*KMAKNSNLTTELEATRSVMPPG
AS*WTLWCPLTRATTPALWRMSTAASTTHTSWM
SWSGPLTGPSCKQGCPPTKQWPWVATWSSCVRC
TVTRSRTSSG*STSR*MGARLAQTTCLMSRS*RL
LELIPPTKRWRCFT*EMSPLRTQGSIRAWRVTL
SDSPITLHG*PFWKPWKRGRQ**PRPCTWRSSS
IAQGPSSSPAWWGRSSSTR*RVVPRRVTSTARWL
CTSWPRASLCADR*QCLLTPVHP*TLGFFWFGH
HGSPPVGLPC*QGSLSMSFPKTLAGSCLGTDWS
*ANPWERAALGRWCWQRLSGWTRTNPTV*PKWL*
RC*SRTQQRKTCQT*SQKWR**R*SGSIRISST
CWGPARRMVPCMSSWSMPPRATCGSTCRPGGPQ
GWNTATTPATTQRSSSPPRTWCPAPTRWPEAWSI
WPPRRCGT*RLPWVMPGWEQSPPSLPACDLS

Frame 2

NLEE*NSPARRPKKVLWKKQLLKVGFREKGRAG
LLQNKEWHEESLAQRHGCCFELWRPIEIEHEQL
VTVAHACNPSTLGGQGRRIA*AHEMEMSLDNMG
QFEKEDRAHCGVSMEMWSLVTNL*LQNWDVELEV
PPLLGCAGHSHTLHR*AVPDLA*TSLPRSPGG*
VVLGQLPLHHSLAIWTWYSA**LEALNRWWYPC
SAGEEPRCSPLLGG******LLFRGERNR*HQTK
PYARSSILDIPRKDGKEIACSAGCQDSEVQMPF
QWDPKPHTALVEKWQRIQT*PQNWRLQGPLCHL
EHHNGLCGAL*QGQLHLHCGE*VRQHQPHIPAGC
RGAVPSPAHPASRVARQQNSGPG*QRGVHV*GV
Q*PAAAHPVAKAHRGEWEQDWPRQPALCPDLED
CWS*YHRQRDGGASLKKCLL*GRRGVYVLGG*LY
RTLPSLCMVDRSGSPGREAGSDDLAPVPGDHHL
LHRGLPHLLHGGVGHRLQDEEWYQEE*LPQPDG
CAQAGQEHPSAQTGNSVC*LQCIHELWGSSGSAI
TALLQWDSHASRGL*V*ASRRPSLGAASGQTGL
RQTPGRGLLWAGGVGRGYRAGQGQTQPCDQSGC
EDVEVGRNRERLVRPDLRNGDDEDDREA*EYHQP
AGGLHAGWSLVCHRGVCLQGQPAGVPAGPEAPR
AGILLQPQPQPRGAALLQGPGVLRLPGGPRHGV
SGLQEGVEPEGSPG*CQGGNRAPLVFQPVTY

Sequence FGFR1.mAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG
CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG
CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT
CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG
TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC
ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG
GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG
AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC
CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGAC
CTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAG
GGGAGGAGGTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGT
CAATGTTTCAGCTTGCCCAGATCTCCAGGAGGCTAAGTGGTGCTCGGCCAGCTTCCACTCCATCACTCCCTTGCCATTTGGACTTGGTACTCGGCTTAGT
GATTAGAGGCCCTGAACAGGTGGTGGTATCCCTGCTCTGCTGGAGAGGAACCCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCT
CTTCAGAGGAGAAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGC
TGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATT
GGAGGCTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCT
  • FGFR1.F11 (forward primer)
  • FGFR1.R11 (reverse primer)
  • Single exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA
AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG
RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS
RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK
VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA
PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA
GTRPLAQATADSPEAEPPRRARVSLKRRIELTV
EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA
TLCTARPSPTLPEQAQPWGAPVEVESFLVHPGD
LLQLRCRLRDDVQSINWLRDGVQLAESNRTRIT
GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSV
NVSACPDLQEAKWCSASFHSITPLPFGLGTRLS
D*RP*TGGGIPALLERNPDALPSSEDDDDDDDS
SSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPA
AKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI
GGYKVRYATWSIIMDSVVPSDKGNYT

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP
QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP
AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV
GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR
SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE
HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR
AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW
SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ
PHSAPLGRPRPCLNKPSPGEPLWKWSPSWSTPVT
CCSFAVGCGTMCRASTGCGTGCSWRKATAPASQ
GRRWRCRTPCPQTPASMLA*PAAPRAVTPPTSP
SMFQLAQISRRLSGARPASTPSLPCHLDLVLGLV
IRGPEQVVVSLLCWRGTQMLSPPRRMMMMMMTP
LQRRKKQITPNQTP*LHIGHPQKRWKRNCMQCR
LPRQ*SSNALPVGPQTPHCAG*KMAKNSNLTTEL
EATRSVMPPGAS*WTLWCPLTRATTP

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR
SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR
PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ
SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG
LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS
TERRRESSAGRGALATPPGPEQSPGAAGRSRGR
GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG
VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS
HTLHR*AVPDLA*TSPALGSPCGSGVLPGPPR*
PAAASLSAAGRCAEHQLAAGRGAAGGKQPHPHHR
GGGGGAGLRARRLRPLCLRNQQPLGQ*HHLLLR
QCFSLPRSPGG*VVLGQLPLHHSLAIWTWYSA*
*LEALNRWWYPCSAGEEPRCSPLLGG******LL
FRGERNR*HQTKPRSSILDIPRKDGKEIACSAG
CQDSEVQMPFQWDPKPHTALVEKWQRIQT*PQN
WRLQGPLCHLEHHNGLCGAL*QGQLH

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