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Sequences

Sequence FGFR1.nAug05

CCTCCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGG AGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGG CCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCA AACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATG CCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGAGCGGTCCCCTC ACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCA CATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGGTAATCATGGCACCAGTCTTC GTGGGCCAGTCTACTGGGAAGGAGACCACTGTCTCGGGGGCTCAAGTTCCTGTGGGCAGGCTCAGTTGCCCCCGAATGGGATCATTCCTCACGCTTCAGG CACACACACTCCATCTCAGTAGGGATCTAGCCACATCCCCCAGGACTAGTAACAGAGGTCACAAAGTGGAGGTGAGCTGGGAACAGAGGGCTGCAGGGAT GGGTGGTGCTGGTCTGTAATAAGCTTTGAGAGCAACGTCACTGGGGCTTTGGGGTCAGCTACACAAGGAAGGCATTTGGACCCCTGCCTTTTCATTGCCC GAAACCAGAGCCTTTCCACCAAGCGTTTCCCAGTCTTAGCCCTGTGTCCTGAGTTACGTACGATCTTTCTGGCAAATGGGGTGCATGATAAGAGCATCTC TTACGAAGAGTTGGAAAAACAAATGCCATATATAAATTCTAAGCCATATGAGGACGAGGAGTAATGGCATTTTCTTCCTTTTTCCTCTCACTCCCAGACA TTCATTGTCCCTGAATGCTCCATTAATCCAGGGAAGGTAATTGCCTAAATCTCCAGTGGATCTCGCAACAGGAAGGAACCAGAAGCTGGGAAAGTTGTTT ACCTCTTTGTCCCAGAGTTAGACCTCATCCTCCCCTAGCTTAGCTGTCTCAGAGATATACTGGCCCTCCCTTCTCTTCTCTTTGCTGCTGGTGCTAAAAC TGCTCTGTAGGTCATTGGCCACTGTCTCCACTCACAACCCCTGCTCCAGTCCTGGAGGGAGTGGGTTAAACACAAATAGAACATTCCATTTGAAGCAGTG ATTCTTTTTTTTTTTTTTTTTTTTTAATCAAATGCTTTGGACTTTTGAAGTCCACTTGTTCTGTACTTGTAAAAGGGAAAGAAGGCCGGGCGCAGTGGCT CACGCCTGTAATCCCAGCACTTTAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAT TAGCTGTGCATAGTGGTTGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAGCTAACTGCTTGAACCCAGAAGGCAGAGGTTGCAGTGAGCTGAG ATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGTGAGACTCTGCGTT

FGFR1.F11 (forward primer)
FGFR1.R11 (reverse primer)
Multiple exon skipping

Frame 0

PPTRARELARRRRLLRSV*KGGSSSLWSIHGDV EPCHQPLTAELGCGAGSASSSGLCWSQPHSAPLG RPRPCLNKMLSPPRRMMMMMMTPLQRRKKQITP NQTVCP*LHIGHPQKRWKRNCMQCRLPRQ*SSN ALPVGPQTPHCAG*KMAKNSNLTTELEATRAVPS PAHPASRVARQQNSGPG*QRGVHV*GVQ*PAAA HPVAKAHRGEWEQDWPRQPALCPDLEGNHGTSL RGPVYWEGDHCLGGSSSCGQAQLPPNGIIPHASG THTPSQ*GSSHIPQD**QRSQSGGELGTEGCRD GWCWSVISFESNVTGALGSATQGRHLDPCLFIA RNQSLSTKRFPVLALCPELRTIFLANGVHDKSIS YEELEKQMPYINSKPYEDEE*WHFLPFSSHSQT FIVPECSINPGKVIA*ISSGSRNRKEPEAGKVV YLFVPELDLILP*LSCLRDILALPSLLFAAGAKT AL*VIGHCLHSQPLLQSWREWVKHK*NIPFEAV ILFFFFFF*SNALDF*SPLVLYL*KGKKAGRSG SRL*SQHFRSLEVRSLRPARPTW*NPISTKNTKI SCA*WLAPVVPATQEAEAS*LLEPRRQRLQ*AE ITPLHSSLGDRVSETLR

Frame 1

LQLALGSWRGGGGSSGQFEKEDRAHCGVSMEMW SLVTNL*LQNWDVELEVPPLLGCAGHSHTLHR* AVPDLA*TRCSPLLGG******LLFRGERNR*HQ TKPYARSSILDIPRKDGKEIACSAGCQDSEVQM PFQWDPKPHTALVEKWQRIQT*PQNWRLQERSP HRPILQAGLPANKTVALGSNVEFMCKVYSDPQPH IQWLKHIEVNGSKIGPDNLPYVQILKVIMAPVF VGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQ AHTLHLSRDLATSPRTSNRGHKVEVSWEQRAAGM GGAGL**ALRATSLGLWGQLHKEGIWTPAFSLP ETRAFPPSVSQS*PCVLSYVRSFWQMGCMIRAS LTKSWKNKCHI*ILSHMRTRSNGIFFLFPLTPRH SLSLNAPLIQGR*LPKSPVDLATGRNQKLGKLF TSLSQS*TSSSPSLAVSEIYWPSLLFSLLLVLK LLCRSLATVSTHNPCSSPGGSGLNTNRTFHLKQ* FFFFFFFFNQMLWTFEVHLFCTCKRERRPGAVA HACNPSTLDHLRSGV*DQPGQHGETPSLLKIQK LAVHSGWHL*SQLLRRLRQANCLNPEGRGCSELR SRHCTPAWVTE*VRLCV

Frame 2

SNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCG ALSPTSNCRTGMWSWKCLLFWAVLVTATLCTAR PSPTLPEQDALPSSEDDDDDDDSSSEEKETDNT KPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKC PSSGTPNPTLRWLKNGKEFKPDHRIGGYKSGPL TGPSCKQGCPPTKQWPWVATWSSCVRCTVTRSR TSSG*STSR*MGARLAQTTCLMSRS*R*SWHQSS WASLLGRRPLSRGLKFLWAGSVAPEWDHSSRFR HTHSISVGI*PHPPGLVTEVTKWR*AGNRGLQG WVVLVCNKL*EQRHWGFGVSYTRKAFGPLPFHCP KPEPFHQAFPSLSPVS*VTYDLSGKWGA**EHL LRRVGKTNAIYKF*AI*GRGVMAFSSFFLSLPD IHCP*MLH*SREGNCLNLQWISQQEGTRSWESCL PLCPRVRPHPPLA*LSQRYTGPPFSSLCCWC*N CSVGHWPLSPLTTPAPVLEGVG*TQIEHSI*SS DSFFFFFFLIKCFGLLKSTCSVLVKGKEGRAQWL TPVIPAL*IT*GQEFETSPANMVKPHLY*KYKN *LCIVVGTCSPSYSGG*GKLTA*TQKAEVAVS* DHATALQPG*QSE*DSA

Sequence FGFR1.kAug05

FGFR1.F11 (forward primer)
FGFR1.R11 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence FGFR1.jAug05

FGFR1.F11 (forward primer)
FGFR1.R11 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence FGFR1.eAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAG AAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAG TGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAA GGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAAC CACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGG AGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTA TGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACG TGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGT ACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGA CTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGG GTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGC CTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCG TGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAG CATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGC AGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGT GGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACAGAGGACAATGTGATGAAGATAGCA GACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTG ACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGA GGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTG CCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGG ACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCT GCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACCCTCACC CACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCTGTGTGGCCTGCCTTCA CCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCACTTCATCCCCTCCCAGAT GTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAACAGGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCC TGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCAGTGCTTCG TGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATACTAGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAG GATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACAAAGTGT ATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGC TATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTA AACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTC

FGFR1.F11 (forward primer)
FGFR1.R11 (reverse primer)
Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA GTRPLAQATADSPEAEPPRRARVSLKRRIELTV EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA TLCTARPSPTLPEQDALPSSEDDDDDDDSSSEE KETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKT VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYK VRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN HTYQLDVVERSPHRPILQAGLPANKTVALGSNV EFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPY VQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPL YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSD FHSQMAVHKLAKSIPLRRQVTVSADSSASMNSG VLLVRPSRLSSSGTPMLAGVSEYELPEDPRWEL PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK HKNIINLLGACTQDGPLYVIVEYASKGNLREYL QARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV PSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPL DQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCL PRHPAQLANGGLKRR*LPPTRPPQTPPSAVTLT HSPCWAHHLSVPVPFPAGRSRLPTRGLPVWPAF TPLSSPLPPPPLHLLVRGAKRQIFAASHFIPSQM LDQHPSLPPGTAWRAGSGSQ*TGMQVRAS*AFS CRFGLFCLHP*APRTLVAGALSSGLQQ*GGQCF VPRLKVTSAPDRWCQWLINSDTSLLC*PNAWYQR MVRRRPGWGQCCGPGAQPQTGGSVYSYEENTKC INLSIYLHVFLKGSLPEIYPSGKMLLVAGRHQL LYIKNKKEKKGKCF*KGHIFFATFAVLFF*IMF* TYFQFRSLNKNCCCF

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ PHSAPLGRPRPCLNKMLSPPRRMMMMMMTPLQRR KKQITPNQTP*LHIGHPQKRWKRNCMQCRLPRQ *SSNALPVGPQTPHCAG*KMAKNSNLTTELEAT RSVMPPGAS*WTLWCPLTRATTPALWRMSTAAST THTSWMSWSGPLTGPSCKQGCPPTKQWPWVATW SSCVRCTVTRSRTSSG*STSR*MGARLAQTTCL MSRS*RLLELIPPTKRWRCFT*EMSPLRTQGSIR AWRVTLSDSPITLHG*PFWKPWKRGRQ**PRPC TWRSSSIAQGPSSSPAWWGRSSSTR*RVVPRRV TSTARWLCTSWPRASLCADR*QCLLTPVHP*TLG FFWFGHHGSPPVGLPC*QGSLSMSFPKTLAGSC LGTDWS*ANPWERAALGRWCWQRLSGWTRTNPT V*PKWL*RC*SRTQQRKTCQT*SQKWR**R*SGS IRISSTCWGPARRMVPCMSSWSMPPRATCGSTC RPGGPQGWNTATTPATTQRSSSPPRTWCPAPTR WPEAWSIWPPRSAYTETWQPGMSW*QRTM**R*Q TLASHGTFTTSTTIKRQPTADCL*SGWHPRHYL TGSTPTRVMCGLSGCSCGRSSLWAAPHTPVCLW RNFSSC*RRVTAWTSPVTAPTSCT**CGTAGMQC PHRDPPSSSWWKTWTASWP*PPTRSTWTCPCPW TSTPPAFPTPGALRAPQGRIPSSLMSRCPRSPA CPDTQPSLPMADSNAADCHPHALPRLHRQL*PSP TAPAGPTTCPSLSPFLLAGAGCLPGAFLCGLPS PHSAHLSLHLLSTCW*EVQRGRSLLPATSSPPR CWTNTPPCHQALPGGQGVGANEQACK*ELPELSP VGLVCFAFTHKPLALWWQVPCPQGYSSREVSAS CLD*R*PLPQIGGASGLLIPILVCFADQMPGTR GW*GEGQVGGSVVALGPSPKLGALYIAMKKTQSV *I*VYIYMSF*KGRYQRFTHRVRCSWWLGGISC YILKTKKKKKENVFKKVIYFLLLLLFYFFKLCS KPIFSLGPSIKIAAA

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS TERRRESSAGRGALATPPGPEQSPGAAGRSRGR GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS HTLHR*AVPDLA*TRCSPLLGG******LLFRG ERNR*HQTKPRSSILDIPRKDGKEIACSAGCQDS EVQMPFQWDPKPHTALVEKWQRIQT*PQNWRLQ GPLCHLEHHNGLCGAL*QGQLHLHCGE*VRQHQ PHIPAGCRGAVPSPAHPASRVARQQNSGPG*QRG VHV*GVQ*PAAAHPVAKAHRGEWEQDWPRQPAL CPDLEDCWS*YHRQRDGGASLKKCLL*GRRGVY VLGG*LYRTLPSLCMVDRSGSPGREAGSDDLAPV PGDHHLLHRGLPHLLHGGVGHRLQDEEWYQEE* LPQPDGCAQAGQEHPSAQTGNSVC*LQCIHELW GSSGSAITALLQWDSHASRGL*V*ASRRPSLGAA SGQTGLRQTPGRGLLWAGGVGRGYRAGQGQTQP CDQSGCEDVEVGRNRERLVRPDLRNGDDEDDRE A*EYHQPAGGLHAGWSLVCHRGVCLQGQPAGVPA GPEAPRAGILLQPQPQPRGAALLQGPGVLRLPG GPRHGVSGLQEVHTPRPGSQECPGDRGQCDEDS RLWPRTGHSPHRLL*KDNQRPTACEVDGTRGII* PDLHPPE*CVVFRGAPVGDLHSGRLPIPRCACG GTFQAAEGGSPHGQAQ*LHQRAVHDDAGLLACS ALTETHLQAAGGRPGPHRGLDLQPGVPGPVHAPG PVLPQLSRHPELYVLLRGGFRLLS*AAARGALP APTPSPACQWRTQTPLTATHTPSPDSTVSCNPH PQPLLGPPPVRPCPLSCWQEPAAYQGPSCVACLH PTQLTSPSTSSPPAGERCKEADLCCQPLHPLPD VGPTPLPATRHCLEGREWEPMNRHASESFLSFL LSVWSVLPSPISPSHSGGRCLVLRATAVGRSVLR ASIEGDLCPR*VVPVAY*FRY*FALLTKCLVPE DGEAKARLGAVLWPWGPAPNWGLCI*L*RKHKV YKSEYIFTCLFKRVVTRDLPIG*DAPGGWEASVA IY*KQKRKKRKMFLKRSYIFCYFCCFIFLNYVL NLFSV*VPQ*KLLLL

Sequence FGFR1.dAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAG AAAGAAACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCA AGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGG CTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGC ATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCA ACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCT GCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAG TATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGC CCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAA GAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAAC TCTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGG AGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACC CAACCGTGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATC GGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGT ACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTA CCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACAGAGGACAATGTGATGAAG ATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCAT TATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCC TGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCAT GCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGC CCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCC CTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACC CTCACCCACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCTGTGTGGCCTG CCTTCACCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCACTTCATCCCCTC CCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAACAGGCATGCAAGTGAGAGCTTCCTGAGCT TTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCAGT GCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATACTAGTTTGCTTTGCTGACCAAATGCCTGGTA CCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACA AAGTGTATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATC AGTTGCTATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTAT GTTCTAAACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTC

FGFR1.F11 (forward primer)
FGFR1.R11 (reverse primer)
Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA GTRPLAQATADSPEAEPPRRARVSLKRRIELTV EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA TLCTARPSPTLPEQDALPSSEDDDDDDDSSSEE KETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS INHTYQLDVVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNL PYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTS PLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKK SDFHSQMAVHKLAKSIPLRRQVTVSADSSASMN SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRW ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMI GKHKNIINLLGACTQDGPLYVIVEYASKGNLRE YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAY QVARGMEYLASKKCIHRDLAARNVLVTEDNVMK IADFGLARDIHHIDYYKKTTNGRLPVKWMAPEA LFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM PLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP CLPRHPAQLANGGLKRR*LPPTRPPQTPPSAVT LTHSPCWAHHLSVPVPFPAGRSRLPTRGLPVWP AFTPLSSPLPPPPLHLLVRGAKRQIFAASHFIPS QMLDQHPSLPPGTAWRAGSGSQ*TGMQVRAS*A FSCRFGLFCLHP*APRTLVAGALSSGLQQ*GGQ CFVPRLKVTSAPDRWCQWLINSDTSLLC*PNAWY QRMVRRRPGWGQCCGPGAQPQTGGSVYSYEENT KCINLSIYLHVFLKGSLPEIYPSGKMLLVAGRH QLLYIKNKKEKKGKCF*KGHIFFATFAVLFF*IM F*TYFQFRSLNKNCCCF

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ PHSAPLGRPRPCLNKMLSPPRRMMMMMMTPLQRR KKQITPNQTVCP*LHIGHPQKRWKRNCMQCRLP RQ*SSNALPVGPQTPHCAG*KMAKNSNLTTELE ATRSVMPPGAS*WTLWCPLTRATTPALWRMSTAA STTHTSWMSWSGPLTGPSCKQGCPPTKQWPWVA TWSSCVRCTVTRSRTSSG*STSR*MGARLAQTT CLMSRS*RLLELIPPTKRWRCFT*EMSPLRTQGS IRAWRVTLSDSPITLHG*PFWKPWKRGRQ**PR PCTWRSSSIAQGPSSSPAWWGRSSSTR*RVVPR RVTSTARWLCTSWPRASLCADR*QCLLTPVHP*T LGFFWFGHHGSPPVGLPC*QGSLSMSFPKTLAG SCLGTDWS*ANPWERAALGRWCWQRLSGWTRTN PTV*PKWL*RC*SRTQQRKTCQT*SQKWR**R*S GSIRISSTCWGPARRMVPCMSSWSMPPRATCGS TCRPGGPQGWNTATTPATTQRSSSPPRTWCPAP TRWPEAWSIWPPRSAYTETWQPGMSW*QRTM**R *QTLASHGTFTTSTTIKRQPTADCL*SGWHPRH YLTGSTPTRVMCGLSGCSCGRSSLWAAPHTPVC LWRNFSSC*RRVTAWTSPVTAPTSCT**CGTAGM QCPHRDPPSSSWWKTWTASWP*PPTRSTWTCPC PWTSTPPAFPTPGALRAPQGRIPSSLMSRCPRS PACPDTQPSLPMADSNAADCHPHALPRLHRQL*P SPTAPAGPTTCPSLSPFLLAGAGCLPGAFLCGL PSPHSAHLSLHLLSTCW*EVQRGRSLLPATSSP PRCWTNTPPCHQALPGGQGVGANEQACK*ELPEL SPVGLVCFAFTHKPLALWWQVPCPQGYSSREVS ASCLD*R*PLPQIGGASGLLIPILVCFADQMPG TRGW*GEGQVGGSVVALGPSPKLGALYIAMKKTQ SV*I*VYIYMSF*KGRYQRFTHRVRCSWWLGGI SCYILKTKKKKKENVFKKVIYFLLLLLFYFFKL CSKPIFSLGPSIKIAAA

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS TERRRESSAGRGALATPPGPEQSPGAAGRSRGR GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS HTLHR*AVPDLA*TRCSPLLGG******LLFRG ERNR*HQTKPYARSSILDIPRKDGKEIACSAGCQ DSEVQMPFQWDPKPHTALVEKWQRIQT*PQNWR LQGPLCHLEHHNGLCGAL*QGQLHLHCGE*VRQ HQPHIPAGCRGAVPSPAHPASRVARQQNSGPG*Q RGVHV*GVQ*PAAAHPVAKAHRGEWEQDWPRQP ALCPDLEDCWS*YHRQRDGGASLKKCLL*GRRG VYVLGG*LYRTLPSLCMVDRSGSPGREAGSDDLA PVPGDHHLLHRGLPHLLHGGVGHRLQDEEWYQE E*LPQPDGCAQAGQEHPSAQTGNSVC*LQCIHE LWGSSGSAITALLQWDSHASRGL*V*ASRRPSLG AASGQTGLRQTPGRGLLWAGGVGRGYRAGQGQT QPCDQSGCEDVEVGRNRERLVRPDLRNGDDEDD REA*EYHQPAGGLHAGWSLVCHRGVCLQGQPAGV PAGPEAPRAGILLQPQPQPRGAALLQGPGVLRL PGGPRHGVSGLQEVHTPRPGSQECPGDRGQCDE DSRLWPRTGHSPHRLL*KDNQRPTACEVDGTRGI I*PDLHPPE*CVVFRGAPVGDLHSGRLPIPRCA CGGTFQAAEGGSPHGQAQ*LHQRAVHDDAGLLA CSALTETHLQAAGGRPGPHRGLDLQPGVPGPVHA PGPVLPQLSRHPELYVLLRGGFRLLS*AAARGA LPAPTPSPACQWRTQTPLTATHTPSPDSTVSCN PHPQPLLGPPPVRPCPLSCWQEPAAYQGPSCVAC LHPTQLTSPSTSSPPAGERCKEADLCCQPLHPL PDVGPTPLPATRHCLEGREWEPMNRHASESFLS FLLSVWSVLPSPISPSHSGGRCLVLRATAVGRSV LRASIEGDLCPR*VVPVAY*FRY*FALLTKCLV PEDGEAKARLGAVLWPWGPAPNWGLCI*L*RKH KVYKSEYIFTCLFKRVVTRDLPIG*DAPGGWEAS VAIY*KQKRKKRKMFLKRSYIFCYFCCFIFLNY VLNLFSV*VPQ*KLLLL

Sequence FGFR1.gAug05

CCCCGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCG CAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGG CCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGT CGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCACAAGG TCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGC ACCGAGCGCCGCCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCGGGCCGGAGCCGGGGACGCG GGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGG AGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGC CACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGATGGCAGCTGTGACCCGGGATTTCGGTGAGATGCTTCTGCACTCTGGCCGGGTCC TGCCAGCCGAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGA TGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCCC GCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAATGTTTCAGATGCTCTCCCCTCCTCGGAGG ATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAA GATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAAT GGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCA ACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGG GTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATC GAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTC ACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGA AGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCG GTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAGACAGG TGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGA GTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCA GAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGA TCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGA GTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTC TCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATG TCCTGGTGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACT GCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACT CTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGC TGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTC CAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTC TTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCC CTCCCCAGACTCCACCGTCAGCTGTAACCCTCACCCACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCT GCCTACCAGGGGCCTTCCTGTGTGGCCTGCCTTCACCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAG ATCTTTGCTGCCAGCCACTTCATCCCCTCCCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAA CAGGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTC CTCAGGGCTACAGCAGTAGGGAGGTCAGTGCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATACT AGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGG GCTCTGTATATAGCTATGAAGAAAACACAAAGTGTATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGG TAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGCTATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCT ACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTAAACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTC

FGFR1.F11 (forward primer)
FGFR1.R11 (reverse primer)
Multiple exon skipping

Frame 0

PRRRIALGALLRPQARRPRRRAAASGSRDAGAA AARGGTRVCRELGGHVRTGPRPLVAHCGDLAFPG RERAAA*KAAEPKDFSPVRARGAPQGARYPCCS RARRGAGASAGRWSPVCKESEAPPLRSGGGGHK VWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRA PSAAGSRAPAAELLRPRQDPNRARGRRAGAGDA GTRPLAQATADSPEAEPPRRARVSLKRRIELTV EYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTA TLCTARPSPTLPEQGWQL*PGISVRCFCTLAGS CQPKPSPGEPLWKWSPSWSTPVTCCSFAVGCGT MCRASTGCGTGCSWRKATAPASQGRRWRCRTPCP QTPASMLA*PAAPRAVTPPTSPSMFQMLSPPRR MMMMMMTPLQRRKKQITPNQTVCP*LHIGHPQK RWKRNCMQCRLPRQ*SSNALPVGPQTPHCAG*KM AKNSNLTTELEATRSVMPPGAS*WTLWCPLTRA TTPALWRMSTAASTTHTSWMSWSGPLTGPSCKQ GCPPTKQWPWVATWSSCVRCTVTRSRTSSG*STS R*MGARLAQTTCLMSRS*RLLELIPPTKRWRCF T*EMSPLRTQGSIRAWRVTLSDSPITLHG*PFW KPWKRGRQ**PRPCTWRSSSIAQGPSSSPAWWGR SSSTR*RVVPRRVTSTARWLCTSWPRASLCADR CLLTPVHP*TLGFFWFGHHGSPPVGLPC*QGSL SMSFPKTLAGSCLGTDWS*ANPWERAALGRWCWQ RLSGWTRTNPTV*PKWL*RC*SRTQQRKTCQT* SQKWR**R*SGSIRISSTCWGPARRMVPCMSSW SMPPRATCGSTCRPGGPQGWNTATTPATTQRSSS PPRTWCPAPTRWPEAWSIWPPRSAYTETWQPGM SW*QRTM**R*QTLASHGTFTTSTTIKRQPTAD CL*SGWHPRHYLTGSTPTRVMCGLSGCSCGRSSL WAAPHTPVCLWRNFSSC*RRVTAWTSPVTAPTS CT**CGTAGMQCPHRDPPSSSWWKTWTASWP*P PTRSTWTCPCPWTSTPPAFPTPGALRAPQGRIPS SLMSRCPRSPACPDTQPSLPMADSNAADCHPHA LPRLHRQL*PSPTAPAGPTTCPSLSPFLLAGAG CLPGAFLCGLPSPHSAHLSLHLLSTCW*EVQRGR SLLPATSSPPRCWTNTPPCHQALPGGQGVGANE QACK*ELPELSPVGLVCFAFTHKPLALWWQVPC PQGYSSREVSASCLD*R*PLPQIGGASGLLIPIL VCFADQMPGTRGW*GEGQVGGSVVALGPSPKLG ALYIAMKKTQSV*I*VYIYMSF*KGRYQRFTHR VRCSWWLGGISCYILKTKKKKKENVFKKVIYFLL LLLFYFFKLCSKPIFSLGPSIKIAAA

Frame 1

PAGA*RSERSCGHRRGVLGGGRQLAGAGTPVQP QRAEEPGCAGSWAATSGRDRDPS*RIAATSPSP AASAPLLEKPRNPRTFLRSELGAPRRAHGTRAAV GHAAAPGPPQGDGARSARKVRRRRCVLEEGGTR SGDPGWRTGALPPPRLRGTSSGSIVPARAGGAE HRAPPGVERRPRSSCDPARTRTEPGGGGPEPGTR AHARSHKPRRTLPRRNLHAERGSV*KGGSSSLW SIHGDVEPCHQPLTAELGCGAGSASSSGLCWSQ PHSAPLGRPRPCLNKDGSCDPGFR*DASALWPGP ASRSPALGSPCGSGVLPGPPR*PAAASLSAAGR CAEHQLAAGRGAAGGKQPHPHHRGGGGGAGLRA RRLRPLCLRNQQPLGQ*HHLLLRQCFRCSPLLGG ******LLFRGERNR*HQTKPYARSSILDIPRK DGKEIACSAGCQDSEVQMPFQWDPKPHTALVEK WQRIQT*PQNWRLQGPLCHLEHHNGLCGAL*QGQ LHLHCGE*VRQHQPHIPAGCRGAVPSPAHPASR VARQQNSGPG*QRGVHV*GVQ*PAAAHPVAKAH RGEWEQDWPRQPALCPDLEDCWS*YHRQRDGGAS LKKCLL*GRRGVYVLGG*LYRTLPSLCMVDRSG SPGREAGSDDLAPVPGDHHLLHRGLPHLLHGGV GHRLQDEEWYQEE*LPQPDGCAQAGQEHPSAQTG VC*LQCIHELWGSSGSAITALLQWDSHASRGL* V*ASRRPSLGAASGQTGLRQTPGRGLLWAGGVG RGYRAGQGQTQPCDQSGCEDVEVGRNRERLVRPD LRNGDDEDDREA*EYHQPAGGLHAGWSLVCHRG VCLQGQPAGVPAGPEAPRAGILLQPQPQPRGAA LLQGPGVLRLPGGPRHGVSGLQEVHTPRPGSQEC PGDRGQCDEDSRLWPRTGHSPHRLL*KDNQRPT ACEVDGTRGII*PDLHPPE*CVVFRGAPVGDLH SGRLPIPRCACGGTFQAAEGGSPHGQAQ*LHQRA VHDDAGLLACSALTETHLQAAGGRPGPHRGLDL QPGVPGPVHAPGPVLPQLSRHPELYVLLRGGFR LLS*AAARGALPAPTPSPACQWRTQTPLTATHTP SPDSTVSCNPHPQPLLGPPPVRPCPLSCWQEPA AYQGPSCVACLHPTQLTSPSTSSPPAGERCKEA DLCCQPLHPLPDVGPTPLPATRHCLEGREWEPMN RHASESFLSFLLSVWSVLPSPISPSHSGGRCLV LRATAVGRSVLRASIEGDLCPR*VVPVAY*FRY *FALLTKCLVPEDGEAKARLGAVLWPWGPAPNWG LCI*L*RKHKVYKSEYIFTCLFKRVVTRDLPIG *DAPGGWEASVAIY*KQKRKKRKMFLKRSYIFC YFCCFIFLNYVLNLFSV*VPQ*KLLLL

Frame 2

PPAHSARSALAATGAASSAAGGS*REPGRRCSR SARRNPGVPGAGRPRPDGTETPRSALRRPRLPR PRARRCLKSRGTQGLFSGPSSGRPAGRTVPVLQ SGTPRRRGLRRAMEPGLQGK*GAAAAFWRRGAQG LETPGGGREPSPRPASGAPAPAPLFPPGLEAPS TERRRESSAGRGALATPPGPEQSPGAAGRSRGR GHTPARTSHGGLSRGGTSTPSEGQFEKEDRAHCG VSMEMWSLVTNL*LQNWDVELEVPPLLGCAGHS HTLHR*AVPDLA*TRMAAVTRDFGEMLLHSGRV LPAEAQPWGAPVEVESFLVHPGDLLQLRCRLRDD VQSINWLRDGVQLAESNRTRITGEEVEVQDSVP ADSGLYACVTSSPSGSDTTYFSVNVSDALPSSE DDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKN GKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG NYTCIVENEYGSINHTYQLDVVERSPHRPILQAG LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVL HLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS VIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ VSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLA EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE YASKGNLREYLQARRPPGLEYCYNPSHNPEEQL SSKDLVSCAYQVARGMEYLASKKCIHRDLAARN VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNE LYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS NQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSV FSHEPLPEEPCLPRHPAQLANGGLKRR*LPPTR PPQTPPSAVTLTHSPCWAHHLSVPVPFPAGRSRL PTRGLPVWPAFTPLSSPLPPPPLHLLVRGAKRQ IFAASHFIPSQMLDQHPSLPPGTAWRAGSGSQ* TGMQVRAS*AFSCRFGLFCLHP*APRTLVAGALS SGLQQ*GGQCFVPRLKVTSAPDRWCQWLINSDT SLLC*PNAWYQRMVRRRPGWGQCCGPGAQPQTG GSVYSYEENTKCINLSIYLHVFLKGSLPEIYPSG KMLLVAGRHQLLYIKNKKEKKGKCF*KGHIFFA TFAVLFF*IMF*TYFQFRSLNKNCCCF