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Sequences

Sequence FANCL.cAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGGAAGTTGCC TTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCCAGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGT ATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGATGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGA ATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCCTCCTGGACACCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATA GAATCACTAAAGGCATTCTGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAA TTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTAAA ACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGATTTTACTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCTGATC AAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATGCTTATATGAGTGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCAT ATTTGGTGAATGTCCATATTGTAGTAAGCCAATTACCTTAAAAATGTCTGGAAGGAAACACTGAAATAAGAATACAACATTTCGGTGAAGAGCTGGAAAC TTAAAAAATTATCAAAAGGAATTTTGGTATCATCTTCAGAGAAAAAATAAAGCAAGAAATACTAACATCAAAAGGACAGGTATGATGATGCGATAATAAT AAACATCTGCGTTTGTCTCTTCACTAAGAGTAAACTGGGAAATTGTAGGCCAAAGTCCAGTTGAACTTTCTAAGTCTGTGATCCCCGTGCTGACTGTGGA AGTGTATTTATACCAAGATGGAGATCTTGACTTCTTGAATATATCTGGACTGGTAAAATCTTGATGAGGCTCATAAAATGAGTTTGGGAATTGTGTATAG CTGATTTTTTGTGGGAAACTGTTTACTTCATTCAAAGGTTCTTGAGACTCTTGATATTTCTGTCTTCTCCTTGTGCTTTCCTATGGAAAAAATACATATA TAGTTTAGTTTGTTAGACGTGAGTTATCCAAGTATTTATTTTGTGTAGTGTGTAAGAATGCTAAATAAAATGTTATACAAGATCAA

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Single exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQEVA LKNRQELYALPPPPQFYSSLIEEIGTLGWDKLV YADTCFSTIKLKAEDASGREHLITLKLKAKYPAE SPDYFVDFPVPFCASWTPQSSLISIYSQFLAAI ESLKAFWDVMDEIDEKTWVLEPEKPPRSATARR IALGNNVSINIEVDPRHPTMLPECFFLGADHVVK PLGIKLSRNIHLWILLWIVEFVMLINLTVPFLI KCVIILSVDNLSIKYAYMSG*EDY*LVDRVLTS YLVNVHIVVSQLP*KCLEGNTEIRIQHFGEELET *KIIKRNFGIIFREKIKQEILTSKGQV**CDNN KHLRLSLH*E*TGKL*AKVQLNFLSL*SPC*LW KCIYTKMEILTS*IYLDW*NLDEAHKMSLGIVYS *FFVGNCLLHSKVLETLDISVFSLCFPMEKIHI *FSLLDVSYPSIYFV*CVRMLNKMLYKI

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRKLP *RIDKSCMHYLLLPSSTQALLKR*ELLVGINLC MRIPASVPSS*KQKMLLVESI*SLSS*RQSILQ NHQIILWIFLFHFVPPGHLRAP**AFIVSFWQQ* NH*RHSGMLWMKSMRRPGYLSQKNLHGVQQHAE LH*VIMFP*I*R*TPGILLCFLSASFLELTMW* NPWELS*AGTYICGFYYGLWNLLCLST*RYHS*S SV**FSVWTTFPSNMLI*VAERTTN**TEF*HH IW*MSIL**ANYLKNVWKETLK*EYNISVKSWK LKKLSKGILVSSSEKK*SKKY*HQKDRYDDAIII NICVCLFTKSKLGNCRPKSS*TF*VCDPRADCG SVFIPRWRS*LLEYIWTGKILMRLIK*VWELCI ADFLWETVYFIQRFLRLLIFLSSPCAFLWKKYIY SLVC*T*VIQVFILCSV*EC*IKCYTRS

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTGSC LKE*TRAVCTTSSSPVLLKPY*RDRNSWLG*TCV CGYLLQYHQVKSRRCFW*RAFNHSQVEGKVSCR ITRLFCGFSCSILCLLDTSELLNKHL*SVFGSN RITKGILGCYG*NR*EDLGT*ARKTSTECNSTQN CIR**CFHKYRGRPQASYYAS*VLLSWS*PCGK TPGN*AEQEHTFVDFTMDCGICYAYQLDGTIPD QVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNII FGECPYCSKPITLKMSGRKH*NKNTTFR*RAGN LKNYQKEFWYHLQRKNKARNTNIKRTGMMMR** *TSAFVSSLRVNWEIVGQSPVELSKSVIPVLTVE VYLYQDGDLDFLNISGLVKS**GS*NEFGNCV* LIFCGKLFTSFKGS*DS*YFCLLLVLSYGKNTY IV*FVRRELSKYLFCVVCKNAK*NVIQDQ

Sequence FANCL.hAug05

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Single exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQEL*LVYADT CFSTIKLKAEDASGREHLITLKLKAKYPAESPDY FVDFPVPFCASWTPQVNSPQSSLISIYSQFLAA IESLKAFWDVMDEIDEKTWVLEPE

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCNLCMRIP ASVPSS*KQKMLLVESI*SLSS*RQSILQNHQI ILWIFLFHFVPPGHLR*ILLRAP**AFIVSFWQQ *NH*RHSGMLWMKSMRRPGYLSQK

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVTCVCGYL LQYHQVKSRRCFW*RAFNHSQVEGKVSCRITRL FCGFSCSILCLLDTSGKFSSELLNKHL*SVFGS NRITKGILGCYG*NR*EDLGT*ARK

Sequence FANCL.aAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTATGGATGAAATCGATG AGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTAGACCC CAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGGAT CCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGATTTTACTATGGATTGTGGAA TTTGTTATGCTTATCAACTTGACGGTACCATTCCTGATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATGCTTATATGAGTGGCT GAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCATATTGTAGTAAGCCAATTACCTTAAAAATGTCTGGAAGGAAACAC TGAAATAAGAATACAACATTTCGGTGAAGAGCTGGAAACTTAAAAAATTATCAAAAGGAATTTTGGTATCATCTTCAGAGAAAAAATAAAGCAAGAAATA CTAACATCAAAAGGACAGGTATGATGATGCGATAATAATAAACATCTGCGTTTGTCTCTTCACTAAGAGTAAACTGGGAAATTGTAGGCCAAAGTCCAGT TGAACTTTCTAAGTCTGTGATCCCCGTGCTGACTGTGGAAGTGTATTTATACCAAGATGGAGATCTTGACTTCTTGAATATATCTGGACTGGTAAAATCT TGATGAGGCTCATAAAATGAGTTTGGGAATTGTGTATAGCTGATTTTTTGTGGGAAACTGTTTACTTCATTCAAAGGTTCTTGAGACTCTTGATATTTCT GTCTTCTCCTTGTGCTTTCCTATGGAAAAAATACATATATAGTTTAGTTTGTTAGACGTGAGTTATCCAAGTATTTATTTTGTGTAGTGTGTAAGAATGC TAAATAAAATGTTATACAAGATCAA

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Single exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQSSLISIYSQFLAAIESLKAFWDVMDEID EKTWVLEPEKPPRSATARRIALGNNVSINIEVDP RHPTMLPECFFLGADHVVKPLGIKLSRNIHLWD PENSVLQNLKDVLEIDFPARAILEKSDFTMDCG ICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWL RGLLTSRQSFNIIFGECPYCSKPITLKMSGRKH *NKNTTFR*RAGNLKNYQKEFWYHLQRKNKARN TNIKRTGMMMR***TSAFVSSLRVNWEIVGQSPV ELSKSVIPVLTVEVYLYQDGDLDFLNISGLVKS **GS*NEFGNCV*LIFCGKLFTSFKGS*DS*YF CLLLVLSYGKNTYIV*FVRRELSKYLFCVVCKNA K*NVIQDQ

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLRAP**AFIVSFWQQ*NH*RHSGMLWMKSM RRPGYLSQKNLHGVQQHAELH*VIMFP*I*R*T PGILLCFLSASFLELTMW*NPWELS*AGTYICGI QKIVCYKI*KMF*KLIFQLVLSWKNLILLWIVE FVMLINLTVPFLIKCVIILSVDNLSIKYAYMSG *EDY*LVDRVLTSYLVNVHIVVSQLP*KCLEGNT EIRIQHFGEELET*KIIKRNFGIIFREKIKQEI LTSKGQV**CDNNKHLRLSLH*E*TGKL*AKVQ LNFLSL*SPC*LWKCIYTKMEILTS*IYLDW*NL DEAHKMSLGIVYS*FFVGNCLLHSKVLETLDIS VFSLCFPMEKIHI*FSLLDVSYPSIYFV*CVRM LNKMLYKI

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSELLNKHL*SVFGSNRITKGILGCYG*NR* EDLGT*ARKTSTECNSTQNCIR**CFHKYRGRP QASYYAS*VLLSWS*PCGKTPGN*AEQEHTFVG SRK*CVTKFERCFRN*FSSSCYPGKI*FYYGLWN LLCLST*RYHS*SSV**FSVWTTFPSNMLI*VA ERTTN**TEF*HHIW*MSIL**ANYLKNVWKET LK*EYNISVKSWKLKKLSKGILVSSSEKK*SKKY *HQKDRYDDAIIINICVCLFTKSKLGNCRPKSS *TF*VCDPRADCGSVFIPRWRS*LLEYIWTGKI LMRLIK*VWELCIADFLWETVYFIQRFLRLLIFL SSPCAFLWKKYIYSLVC*T*VIQVFILCSV*EC *IKCYTRS

Sequence FANCL.bAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGGTAAATTCTCCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTA TGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAA TATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAAC ATACATTTGTGGGATCCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGATTTTA CTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCTGATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATG CTTATATGAGTGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCATATTGTAGTAAGCCAATTACCTTAAAAATG TCTGGAAGGAAACACTGAAATAAGAATACAACATTTCGGTGAAGAGCTGGAAACTTAAAAAATTATCAAAAGGAATTTTGGTATCATCTTCAGAGAAAAA ATAAAGCAAGAAATACTAACATCAAAAGGACAGGTATGATGATGCGATAATAATAAACATCTGCGTTTGTCTCTTCACTAAGAGTAAACTGGGAAATTGT AGGCCAAAGTCCAGTTGAACTTTCTAAGTCTGTGATCCCCGTGCTGACTGTGGAAGTGTATTTATACCAAGATGGAGATCTTGACTTCTTGAATATATCT GGACTGGTAAAATCTTGATGAGGCTCATAAAATGAGTTTGGGAATTGTGTATAGCTGATTTTTTGTGGGAAACTGTTTACTTCATTCAAAGGTTCTTGAG ACTCTTGATATTTCTGTCTTCTCCTTGTGCTTTCCTATGGAAAAAATACATATATAGTTTAGTTTGTTAGACGTGAGTTATCCAAGTATTTATTTTGTGT AGTGTGTAAGAATGCTAAATAAAATGTTATACAAGATCAA

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Single exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQVNSPQSSLISIYSQFLAAIESLKAFWDV MDEIDEKTWVLEPEKPPRSATARRIALGNNVSIN IEVDPRHPTMLPECFFLGADHVVKPLGIKLSRN IHLWDPENSVLQNLKDVLEIDFPARAILEKSDF TMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQIC LYEWLRGLLTSRQSFNIIFGECPYCSKPITLKM SGRKH*NKNTTFR*RAGNLKNYQKEFWYHLQRK NKARNTNIKRTGMMMR***TSAFVSSLRVNWEIV GQSPVELSKSVIPVLTVEVYLYQDGDLDFLNIS GLVKS**GS*NEFGNCV*LIFCGKLFTSFKGS* DS*YFCLLLVLSYGKNTYIV*FVRRELSKYLFCV VCKNAK*NVIQDQ

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLR*ILLRAP**AFIVSFWQQ*NH*RHSGML WMKSMRRPGYLSQKNLHGVQQHAELH*VIMFP* I*R*TPGILLCFLSASFLELTMW*NPWELS*AGT YICGIQKIVCYKI*KMF*KLIFQLVLSWKNLIL LWIVEFVMLINLTVPFLIKCVIILSVDNLSIKY AYMSG*EDY*LVDRVLTSYLVNVHIVVSQLP*KC LEGNTEIRIQHFGEELET*KIIKRNFGIIFREK IKQEILTSKGQV**CDNNKHLRLSLH*E*TGKL *AKVQLNFLSL*SPC*LWKCIYTKMEILTS*IYL DW*NLDEAHKMSLGIVYS*FFVGNCLLHSKVLE TLDISVFSLCFPMEKIHI*FSLLDVSYPSIYFV *CVRMLNKMLYKI

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSGKFSSELLNKHL*SVFGSNRITKGILGCY G*NR*EDLGT*ARKTSTECNSTQNCIR**CFHK YRGRPQASYYAS*VLLSWS*PCGKTPGN*AEQE HTFVGSRK*CVTKFERCFRN*FSSSCYPGKI*FY YGLWNLLCLST*RYHS*SSV**FSVWTTFPSNM LI*VAERTTN**TEF*HHIW*MSIL**ANYLKN VWKETLK*EYNISVKSWKLKKLSKGILVSSSEKK *SKKY*HQKDRYDDAIIINICVCLFTKSKLGNC RPKSS*TF*VCDPRADCGSVFIPRWRS*LLEYI WTGKILMRLIK*VWELCIADFLWETVYFIQRFLR LLIFLSSPCAFLWKKYIYSLVC*T*VIQVFILC SV*EC*IKCYTRS

Sequence FANCL.eAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGGTCACTGATCAAGCAAAAATGGATGTGAAAATTGCGGTTTTGCCTAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAA TAGAATCACTAAAGGCATTCTGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAG AATTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGGTATG ACATCTGAGATTTAAACGTTTTTTAATAGAGTCATAAAATCCTTGCCTAGCATTGTTAAATTATTAGACAATATTAGTATATTAATGGTAGTTTTTATTT TTTGTCTGAGACGGAGTTTTGCTCTTGTTGCCCAGTATGTAGTGTAATGGCGCGATCTCGGTTCACCGCAATAATGATAGTTATTTTAAATGACAATGTC TCAGCATTCTGAACTGTATAATTTTGTTTTTTAACATAATACATATAATTTTGATTTTCTAATCAAGTAGTTAAGAAACATTCTGTATCAAATGTGGCTT TAGAAACCAAGAGTAGAGCATGCAATTATTAAATTTTTTTTTTTTAATCTGAAGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTG GTAGGTACCTTGGCAATATAATTTTTACTTTTTGGTGATTTTACAAAGTTCACAGCATAATTTTTTTCCCCATGCTTTCAGGGATCCAGAAAATAGTGTG TTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGTAAGTTTTATCAGTGTTTTGATATTCCAGACAGTAT TGCATAATGAAGTTTAAATGCTTCTCTCAGTGAAAAATGAGGCTGAAAAAGGAGGGAATTAGAAAAATATTATAACACAGACTTCTGATCTGCATCAAAA AACTTGTTTACCTTTGATTGGTTGTTAAGTACAACTGTCTCTTGGAACAGGGGGATTGATTTCAGGGCTGCCCATGGATACAAAAATCCACAGACATTAA AGTTCCACAGTTACCCTGCAGGACCCATATATAGAAGAAGTCGGCCCTCTGTATACAGAGATTTCACATAAACACAGGTTCTGCATCTTGTCAGTACTGT ATTTTTGATCTGCATTTGGTTAAAAAAAAAATCTGTGTATAAGTAGACCTGTGCAGTTCAAACCCATGTTGTTCAAGGGTCAACTATATACTTTTTTCAT GGTCTTCAGTAGTGACGTCATTAATGACAGACATTTATTAAAAATAAGGGG

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Single exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQVTDQAKMDVKIAVLPSSLISIYSQFLAA IESLKAFWDVMDEIDEKTWVLEPEKPPRSATARR IALGNNVSINIEVDPRHPTMLPECFFLGADHGM TSEI*TFFNRVIKSLPSIVKLLDNISILMVVFI FCLRRSFALVAQYVV*WRDLGSPQ***LF*MTMS QHSELYNFVF*HNTYNFDFLIK*LRNILYQMWL *KPRVEHAIIKFFFFNLKW*NPWELS*AGTYIC GRYLGNIIFTFW*FYKVHSIIFFPMLSGIQKIVC YKI*KMF*KLIFQLVLSWKNL*VLSVF*YSRQY CIMKFKCFSQ*KMRLKKEGIRKIL*HRLLICIK KLVYL*LVVKYNCLLEQGD*FQGCPWIQKSTDIK VPQLPCRTHI*KKSALCIQRFHINTGSASCQYC IFDLHLVKKKICV*VDLCSSNPCCSRVNYILFS WSSVVTSLMTDIY*K*G

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLRSLIKQKWM*KLRFCLAP**AFIVSFWQQ *NH*RHSGMLWMKSMRRPGYLSQKNLHGVQQHA ELH*VIMFP*I*R*TPGILLCFLSASFLELTMV* HLRFKRFLIES*NPCLALLNY*TILVY*W*FLF FV*DGVLLLLPSM*CNGAISVHRNNDSYFK*QC LSILNCIILFFNIIHIILIF*SSS*ETFCIKCGF RNQE*SMQLLNFFFLI*SGKTPGN*AEQEHTFV VGTLAI*FLLFGDFTKFTA*FFSPCFQGSRK*C VTKFERCFRN*FSSSCYPGKICKFYQCFDIPDSI A**SLNASLSEK*G*KRRELEKYYNTDF*SASK NLFTFDWLLSTTVSWNRGIDFRAAHGYKNPQTL KFHSYPAGPIYRRSRPSVYRDFT*TQVLHLVSTV FLICIWLKKKSVYK*TCAVQTHVVQGSTIYFFH GLQ**RH**QTFIKNKG

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSGH*SSKNGCENCGFA*LLNKHL*SVFGSN RITKGILGCYG*NR*EDLGT*ARKTSTECNSTQ NCIR**CFHKYRGRPQASYYAS*VLLSWS*PWY DI*DLNVF**SHKILA*HC*IIRQY*YINGSFYF LSETEFCSCCPVCSVMARSRFTAIMIVILNDNV SAF*TV*FCFLT*YI*F*FSNQVVKKHSVSNVA LETKSRACNY*IFFF*SEVVKPLGIKLSRNIHLW *VPWQYNFYFLVILQSSQHNFFPHAFRDPENSV LQNLKDVLEIDFPARAILEKSVSFISVLIFQTV LHNEV*MLLSVKNEAEKGGN*KNIITQTSDLHQK TCLPLIGC*VQLSLGTGGLISGLPMDTKIHRH* SSTVTLQDPYIEEVGPLYTEISHKHRFCILSVL YF*SAFG*KKNLCISRPVQFKPMLFKGQLYTFFM VFSSDVINDRHLLKIR

Sequence FANCL.fAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGGTAAATTCTCCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTA TGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAA TATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGGTATGACATCTGAGATTTAAACGTTTTTTAATAGA GTCATAAAATCCTTGCCTAGCATTGTTAAATTATTAGACAATATTAGTATATTAATGGTAGTTTTTATTTTTTGTCTGAGACGGAGTTTTGCTCTTGTTG CCCAGTATGTAGTGTAATGGCGCGATCTCGGTTCACCGCAATAATGATAGTTATTTTAAATGACAATGTCTCAGCATTCTGAACTGTATAATTTTGTTTT TTAACATAATACATATAATTTTGATTTTCTAATCAAGTAGTTAAGAAACATTCTGTATCAAATGTGGCTTTAGAAACCAAGAGTAGAGCATGCAATTATT AAATTTTTTTTTTTTAATCTGAAGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGTAGGTACCTTGGCAATATAATTTTTACTT TTTGGTGATTTTACAAAGTTCACAGCATAATTTTTTTCCCCATGCTTTCAGGGATCCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATT GATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGTAAGTTTTATCAGTGTTTTGATATTCCAGACAGTATTGCATAATGAAGTTTAAATGCTTCTCTCAG TGAAAAATGAGGCTGAAAAAGGAGGGAATTAGAAAAATATTATAACACAGACTTCTGATCTGCATCAAAAAACTTGTTTACCTTTGATTGGTTGTTAAGT ACAACTGTCTCTTGGAACAGGGGGATTGATTTCAGGGCTGCCCATGGATACAAAAATCCACAGACATTAAAGTTCCACAGTTACCCTGCAGGACCCATAT ATAGAAGAAGTCGGCCCTCTGTATACAGAGATTTCACATAAACACAGGTTCTGCATCTTGTCAGTACTGTATTTTTGATCTGCATTTGGTTAAAAAAAAA ATCTGTGTATAAGTAGACCTGTGCAGTTCAAACCCATGTTGTTCAAGGGTCAACTATATACTTTTTTCATGGTCTTCAGTAGTGACGTCATTAATGACAG ACATTTATTAAAAATAAGGGG

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Single exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQVNSPQSSLISIYSQFLAAIESLKAFWDV MDEIDEKTWVLEPEKPPRSATARRIALGNNVSIN IEVDPRHPTMLPECFFLGADHGMTSEI*TFFNR VIKSLPSIVKLLDNISILMVVFIFCLRRSFALV AQYVV*WRDLGSPQ***LF*MTMSQHSELYNFVF *HNTYNFDFLIK*LRNILYQMWL*KPRVEHAII KFFFFNLKW*NPWELS*AGTYICGRYLGNIIFT FW*FYKVHSIIFFPMLSGIQKIVCYKI*KMF*KL IFQLVLSWKNL*VLSVF*YSRQYCIMKFKCFSQ *KMRLKKEGIRKIL*HRLLICIKKLVYL*LVVK YNCLLEQGD*FQGCPWIQKSTDIKVPQLPCRTHI *KKSALCIQRFHINTGSASCQYCIFDLHLVKKK ICV*VDLCSSNPCCSRVNYILFSWSSVVTSLMT DIY*K*G

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLR*ILLRAP**AFIVSFWQQ*NH*RHSGML WMKSMRRPGYLSQKNLHGVQQHAELH*VIMFP* I*R*TPGILLCFLSASFLELTMV*HLRFKRFLIE S*NPCLALLNY*TILVY*W*FLFFV*DGVLLLL PSM*CNGAISVHRNNDSYFK*QCLSILNCIILF FNIIHIILIF*SSS*ETFCIKCGFRNQE*SMQLL NFFFLI*SGKTPGN*AEQEHTFVVGTLAI*FLL FGDFTKFTA*FFSPCFQGSRK*CVTKFERCFRN *FSSSCYPGKICKFYQCFDIPDSIA**SLNASLS EK*G*KRRELEKYYNTDF*SASKNLFTFDWLLS TTVSWNRGIDFRAAHGYKNPQTLKFHSYPAGPI YRRSRPSVYRDFT*TQVLHLVSTVFLICIWLKKK SVYK*TCAVQTHVVQGSTIYFFHGLQ**RH**Q TFIKNKG

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSGKFSSELLNKHL*SVFGSNRITKGILGCY G*NR*EDLGT*ARKTSTECNSTQNCIR**CFHK YRGRPQASYYAS*VLLSWS*PWYDI*DLNVF** SHKILA*HC*IIRQY*YINGSFYFLSETEFCSCC PVCSVMARSRFTAIMIVILNDNVSAF*TV*FCF LT*YI*F*FSNQVVKKHSVSNVALETKSRACNY *IFFF*SEVVKPLGIKLSRNIHLW*VPWQYNFYF LVILQSSQHNFFPHAFRDPENSVLQNLKDVLEI DFPARAILEKSVSFISVLIFQTVLHNEV*MLLS VKNEAEKGGN*KNIITQTSDLHQKTCLPLIGC*V QLSLGTGGLISGLPMDTKIHRH*SSTVTLQDPY IEEVGPLYTEISHKHRFCILSVLYF*SAFG*KK NLCISRPVQFKPMLFKGQLYTFFMVFSSDVINDR HLLKIR