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Sequences

Sequence FANCL.dAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGACTTGTGTATGCGGATACCTGCTTCAGTA CCATCAAGTTAAAAGCAGAAGATGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGA TTTTCCTGTTCCATTTTGTGCCTCCTGGACACCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGG GATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTT CCATAAATATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTAAAACCCCTGGGAATTAAGCTGAG CAGGAACATACATTTGTGGGATCCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCT GATTTTACTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCTGATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATC AAATATGCTTATATGAGTGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCATATTGTAGTAAGCCAATTACCTT AAAAATGTCTGGAAGGAAACACTGAAATAAGAATACAACATTTCGGTGAAGAGCTGGAAACTTAAAAAATTATCAAAAGGAATTTTGGTATCATCTTCAG AGAAAAAATAAAGCAAGAAATACTAACATCAAAAGGACAGGTATGATGATGCGATAATAATAAACATCTGCGTTTGTCTCTTCACTAAGAGTAAACTGGG AAATTGTAGGCCAAAGTCCAGTTGAACTTTCTAAGTCTGTGATCCCCGTGCTGACTGTGGAAGTGTATTTATACCAAGATGGAGATCTTGACTTCTTGAA TATATCTGGACTGGTAAAATCTTGATGAGGCTCATAAAATGAGTTTGGGAATTGTGTATAGCTGATTTTTTGTGGGAAACTGTTTACTTCATTCAAAGGT TCTTGAGACTCTTGATATTTCTGTCTTCTCCTTGTGCTTTCCTATGGAAAAAATACATATATAGTTTAGTTTGTTAGACGTGAGTTATCCAAGTATTTAT TTTGTGTAGTGTGTAAGAATGCTAAATAAAATGTTATACAAGATCAA

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Multiple exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQTCVCGYLLQY HQVKSRRCFW*RAFNHSQVEGKVSCRITRLFCG FSCSILCLLDTSELLNKHL*SVFGSNRITKGIL GCYG*NR*EDLGT*ARKTSTECNSTQNCIR**CF HKYRGRPQASYYAS*VLLSWS*PCGKTPGN*AE QEHTFVGSRK*CVTKFERCFRN*FSSSCYPGKI *FYYGLWNLLCLST*RYHS*SSV**FSVWTTFPS NMLI*VAERTTN**TEF*HHIW*MSIL**ANYL KNVWKETLK*EYNISVKSWKLKKLSKGILVSSS EKK*SKKY*HQKDRYDDAIIINICVCLFTKSKLG NCRPKSS*TF*VCDPRADCGSVFIPRWRS*LLE YIWTGKILMRLIK*VWELCIADFLWETVYFIQR FLRLLIFLSSPCAFLWKKYIYSLVC*T*VIQVFI LCSV*EC*IKCYTRS

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLRLVYADTCFS TIKLKAEDASGREHLITLKLKAKYPAESPDYFVD FPVPFCASWTPQSSLISIYSQFLAAIESLKAFW DVMDEIDEKTWVLEPEKPPRSATARRIALGNNV SINIEVDPRHPTMLPECFFLGADHVVKPLGIKLS RNIHLWDPENSVLQNLKDVLEIDFPARAILEKS DFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFH QICLYEWLRGLLTSRQSFNIIFGECPYCSKPITL KMSGRKH*NKNTTFR*RAGNLKNYQKEFWYHLQ RKNKARNTNIKRTGMMMR***TSAFVSSLRVNW EIVGQSPVELSKSVIPVLTVEVYLYQDGDLDFLN ISGLVKS**GS*NEFGNCV*LIFCGKLFTSFKG S*DS*YFCLLLVLSYGKNTYIV*FVRRELSKYL FCVVCKNAK*NVIQDQ

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSDLCMRIPASV PSS*KQKMLLVESI*SLSS*RQSILQNHQIILW IFLFHFVPPGHLRAP**AFIVSFWQQ*NH*RHSG MLWMKSMRRPGYLSQKNLHGVQQHAELH*VIMF P*I*R*TPGILLCFLSASFLELTMW*NPWELS* AGTYICGIQKIVCYKI*KMF*KLIFQLVLSWKNL ILLWIVEFVMLINLTVPFLIKCVIILSVDNLSI KYAYMSG*EDY*LVDRVLTSYLVNVHIVVSQLP *KCLEGNTEIRIQHFGEELET*KIIKRNFGIIFR EKIKQEILTSKGQV**CDNNKHLRLSLH*E*TG KL*AKVQLNFLSL*SPC*LWKCIYTKMEILTS* IYLDW*NLDEAHKMSLGIVYS*FFVGNCLLHSKV LETLDISVFSLCFPMEKIHI*FSLLDVSYPSIY FV*CVRMLNKMLYKI

Sequence FANCL.jAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGACTTGTGTATGCGGATACCTGCTTCAGTA CCATCAAGTTAAAAGCAGAAGATGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGA TTTTCCTGTTCCATTTTGTGCCTCCTGGACACCTCAGGTAAATTCTCCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCA CTAAAGGCATTCTGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCAT TAGGTAATAATGTTTCCATAAATATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGGTATGACATCTGA GATTTAAACGTTTTTTAATAGAGTCATAAAATCCTTGCCTAGCATTGTTAAATTATTAGACAATATTAGTATATTAATGGTAGTTTTTATTTTTTGTCTG AGACGGAGTTTTGCTCTTGTTGCCCAGTATGTAGTGTAATGGCGCGATCTCGGTTCACCGCAATAATGATAGTTATTTTAAATGACAATGTCTCAGCATT CTGAACTGTATAATTTTGTTTTTTAACATAATACATATAATTTTGATTTTCTAATCAAGTAGTTAAGAAACATTCTGTATCAAATGTGGCTTTAGAAACC AAGAGTAGAGCATGCAATTATTAAATTTTTTTTTTTTAATCTGAAGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGTAGGTAC CTTGGCAATATAATTTTTACTTTTTGGTGATTTTACAAAGTTCACAGCATAATTTTTTTCCCCATGCTTTCAGGGATCCAGAAAATAGTGTGTTACAAAA TTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGTAAGTTTTATCAGTGTTTTGATATTCCAGACAGTATTGCATAAT GAAGTTTAAATGCTTCTCTCAGTGAAAAATGAGGCTGAAAAAGGAGGGAATTAGAAAAATATTATAACACAGACTTCTGATCTGCATCAAAAAACTTGTT TACCTTTGATTGGTTGTTAAGTACAACTGTCTCTTGGAACAGGGGGATTGATTTCAGGGCTGCCCATGGATACAAAAATCCACAGACATTAAAGTTCCAC AGTTACCCTGCAGGACCCATATATAGAAGAAGTCGGCCCTCTGTATACAGAGATTTCACATAAACACAGGTTCTGCATCTTGTCAGTACTGTATTTTTGA TCTGCATTTGGTTAAAAAAAAAATCTGTGTATAAGTAGACCTGTGCAGTTCAAACCCATGTTGTTCAAGGGTCAACTATATACTTTTTTCATGGTCTTCA GTAGTGACGTCATTAATGACAGACATTTATTAAAAATAAGGGG

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Multiple exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQTCVCGYLLQY HQVKSRRCFW*RAFNHSQVEGKVSCRITRLFCG FSCSILCLLDTSGKFSSELLNKHL*SVFGSNRI TKGILGCYG*NR*EDLGT*ARKTSTECNSTQNCI R**CFHKYRGRPQASYYAS*VLLSWS*PWYDI* DLNVF**SHKILA*HC*IIRQY*YINGSFYFLS ETEFCSCCPVCSVMARSRFTAIMIVILNDNVSAF *TV*FCFLT*YI*F*FSNQVVKKHSVSNVALET KSRACNY*IFFF*SEVVKPLGIKLSRNIHLW*V PWQYNFYFLVILQSSQHNFFPHAFRDPENSVLQN LKDVLEIDFPARAILEKSVSFISVLIFQTVLHN EV*MLLSVKNEAEKGGN*KNIITQTSDLHQKTC LPLIGC*VQLSLGTGGLISGLPMDTKIHRH*SST VTLQDPYIEEVGPLYTEISHKHRFCILSVLYF* SAFG*KKNLCISRPVQFKPMLFKGQLYTFFMVF SSDVINDRHLLKIR

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLRLVYADTCFS TIKLKAEDASGREHLITLKLKAKYPAESPDYFVD FPVPFCASWTPQVNSPQSSLISIYSQFLAAIES LKAFWDVMDEIDEKTWVLEPEKPPRSATARRIA LGNNVSINIEVDPRHPTMLPECFFLGADHGMTSE I*TFFNRVIKSLPSIVKLLDNISILMVVFIFCL RRSFALVAQYVV*WRDLGSPQ***LF*MTMSQH SELYNFVF*HNTYNFDFLIK*LRNILYQMWL*KP RVEHAIIKFFFFNLKW*NPWELS*AGTYICGRY LGNIIFTFW*FYKVHSIIFFPMLSGIQKIVCYK I*KMF*KLIFQLVLSWKNL*VLSVF*YSRQYCIM KFKCFSQ*KMRLKKEGIRKIL*HRLLICIKKLV YL*LVVKYNCLLEQGD*FQGCPWIQKSTDIKVP QLPCRTHI*KKSALCIQRFHINTGSASCQYCIFD LHLVKKKICV*VDLCSSNPCCSRVNYILFSWSS VVTSLMTDIY*K*G

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSDLCMRIPASV PSS*KQKMLLVESI*SLSS*RQSILQNHQIILW IFLFHFVPPGHLR*ILLRAP**AFIVSFWQQ*NH *RHSGMLWMKSMRRPGYLSQKNLHGVQQHAELH *VIMFP*I*R*TPGILLCFLSASFLELTMV*HL RFKRFLIES*NPCLALLNY*TILVY*W*FLFFV* DGVLLLLPSM*CNGAISVHRNNDSYFK*QCLSI LNCIILFFNIIHIILIF*SSS*ETFCIKCGFRN QE*SMQLLNFFFLI*SGKTPGN*AEQEHTFVVGT LAI*FLLFGDFTKFTA*FFSPCFQGSRK*CVTK FERCFRN*FSSSCYPGKICKFYQCFDIPDSIA* *SLNASLSEK*G*KRRELEKYYNTDF*SASKNLF TFDWLLSTTVSWNRGIDFRAAHGYKNPQTLKFH SYPAGPIYRRSRPSVYRDFT*TQVLHLVSTVFL ICIWLKKKSVYK*TCAVQTHVVQGSTIYFFHGLQ **RH**QTFIKNKG

Sequence FANCL.aAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTATGGATGAAATCGATG AGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTAGACCC CAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGGAT CCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGATTTTACTATGGATTGTGGAA TTTGTTATGCTTATCAACTTGACGGTACCATTCCTGATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATGCTTATATGAGTGGCT GAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCATATTGTAGTAAGCCAATTACCTTAAAAATGTCTGGAAGGAAACAC TGAAATAAGAATACAACATTTCGGTGAAGAGCTGGAAACTTAAAAAATTATCAAAAGGAATTTTGGTATCATCTTCAGAGAAAAAATAAAGCAAGAAATA CTAACATCAAAAGGACAGGTATGATGATGCGATAATAATAAACATCTGCGTTTGTCTCTTCACTAAGAGTAAACTGGGAAATTGTAGGCCAAAGTCCAGT TGAACTTTCTAAGTCTGTGATCCCCGTGCTGACTGTGGAAGTGTATTTATACCAAGATGGAGATCTTGACTTCTTGAATATATCTGGACTGGTAAAATCT TGATGAGGCTCATAAAATGAGTTTGGGAATTGTGTATAGCTGATTTTTTGTGGGAAACTGTTTACTTCATTCAAAGGTTCTTGAGACTCTTGATATTTCT GTCTTCTCCTTGTGCTTTCCTATGGAAAAAATACATATATAGTTTAGTTTGTTAGACGTGAGTTATCCAAGTATTTATTTTGTGTAGTGTGTAAGAATGC TAAATAAAATGTTATACAAGATCAA

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Multiple exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQSSLISIYSQFLAAIESLKAFWDVMDEID EKTWVLEPEKPPRSATARRIALGNNVSINIEVDP RHPTMLPECFFLGADHVVKPLGIKLSRNIHLWD PENSVLQNLKDVLEIDFPARAILEKSDFTMDCG ICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWL RGLLTSRQSFNIIFGECPYCSKPITLKMSGRKH *NKNTTFR*RAGNLKNYQKEFWYHLQRKNKARN TNIKRTGMMMR***TSAFVSSLRVNWEIVGQSPV ELSKSVIPVLTVEVYLYQDGDLDFLNISGLVKS **GS*NEFGNCV*LIFCGKLFTSFKGS*DS*YF CLLLVLSYGKNTYIV*FVRRELSKYLFCVVCKNA K*NVIQDQ

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLRAP**AFIVSFWQQ*NH*RHSGMLWMKSM RRPGYLSQKNLHGVQQHAELH*VIMFP*I*R*T PGILLCFLSASFLELTMW*NPWELS*AGTYICGI QKIVCYKI*KMF*KLIFQLVLSWKNLILLWIVE FVMLINLTVPFLIKCVIILSVDNLSIKYAYMSG *EDY*LVDRVLTSYLVNVHIVVSQLP*KCLEGNT EIRIQHFGEELET*KIIKRNFGIIFREKIKQEI LTSKGQV**CDNNKHLRLSLH*E*TGKL*AKVQ LNFLSL*SPC*LWKCIYTKMEILTS*IYLDW*NL DEAHKMSLGIVYS*FFVGNCLLHSKVLETLDIS VFSLCFPMEKIHI*FSLLDVSYPSIYFV*CVRM LNKMLYKI

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSELLNKHL*SVFGSNRITKGILGCYG*NR* EDLGT*ARKTSTECNSTQNCIR**CFHKYRGRP QASYYAS*VLLSWS*PCGKTPGN*AEQEHTFVG SRK*CVTKFERCFRN*FSSSCYPGKI*FYYGLWN LLCLST*RYHS*SSV**FSVWTTFPSNMLI*VA ERTTN**TEF*HHIW*MSIL**ANYLKNVWKET LK*EYNISVKSWKLKKLSKGILVSSSEKK*SKKY *HQKDRYDDAIIINICVCLFTKSKLGNCRPKSS *TF*VCDPRADCGSVFIPRWRS*LLEYIWTGKI LMRLIK*VWELCIADFLWETVYFIQRFLRLLIFL SSPCAFLWKKYIYSLVC*T*VIQVFILCSV*EC *IKCYTRS

Sequence FANCL.bAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGGTAAATTCTCCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTA TGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAA TATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAAC ATACATTTGTGGGATCCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGATTTTA CTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCTGATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATG CTTATATGAGTGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCATATTGTAGTAAGCCAATTACCTTAAAAATG TCTGGAAGGAAACACTGAAATAAGAATACAACATTTCGGTGAAGAGCTGGAAACTTAAAAAATTATCAAAAGGAATTTTGGTATCATCTTCAGAGAAAAA ATAAAGCAAGAAATACTAACATCAAAAGGACAGGTATGATGATGCGATAATAATAAACATCTGCGTTTGTCTCTTCACTAAGAGTAAACTGGGAAATTGT AGGCCAAAGTCCAGTTGAACTTTCTAAGTCTGTGATCCCCGTGCTGACTGTGGAAGTGTATTTATACCAAGATGGAGATCTTGACTTCTTGAATATATCT GGACTGGTAAAATCTTGATGAGGCTCATAAAATGAGTTTGGGAATTGTGTATAGCTGATTTTTTGTGGGAAACTGTTTACTTCATTCAAAGGTTCTTGAG ACTCTTGATATTTCTGTCTTCTCCTTGTGCTTTCCTATGGAAAAAATACATATATAGTTTAGTTTGTTAGACGTGAGTTATCCAAGTATTTATTTTGTGT AGTGTGTAAGAATGCTAAATAAAATGTTATACAAGATCAA

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Multiple exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQVNSPQSSLISIYSQFLAAIESLKAFWDV MDEIDEKTWVLEPEKPPRSATARRIALGNNVSIN IEVDPRHPTMLPECFFLGADHVVKPLGIKLSRN IHLWDPENSVLQNLKDVLEIDFPARAILEKSDF TMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQIC LYEWLRGLLTSRQSFNIIFGECPYCSKPITLKM SGRKH*NKNTTFR*RAGNLKNYQKEFWYHLQRK NKARNTNIKRTGMMMR***TSAFVSSLRVNWEIV GQSPVELSKSVIPVLTVEVYLYQDGDLDFLNIS GLVKS**GS*NEFGNCV*LIFCGKLFTSFKGS* DS*YFCLLLVLSYGKNTYIV*FVRRELSKYLFCV VCKNAK*NVIQDQ

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLR*ILLRAP**AFIVSFWQQ*NH*RHSGML WMKSMRRPGYLSQKNLHGVQQHAELH*VIMFP* I*R*TPGILLCFLSASFLELTMW*NPWELS*AGT YICGIQKIVCYKI*KMF*KLIFQLVLSWKNLIL LWIVEFVMLINLTVPFLIKCVIILSVDNLSIKY AYMSG*EDY*LVDRVLTSYLVNVHIVVSQLP*KC LEGNTEIRIQHFGEELET*KIIKRNFGIIFREK IKQEILTSKGQV**CDNNKHLRLSLH*E*TGKL *AKVQLNFLSL*SPC*LWKCIYTKMEILTS*IYL DW*NLDEAHKMSLGIVYS*FFVGNCLLHSKVLE TLDISVFSLCFPMEKIHI*FSLLDVSYPSIYFV *CVRMLNKMLYKI

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSGKFSSELLNKHL*SVFGSNRITKGILGCY G*NR*EDLGT*ARKTSTECNSTQNCIR**CFHK YRGRPQASYYAS*VLLSWS*PCGKTPGN*AEQE HTFVGSRK*CVTKFERCFRN*FSSSCYPGKI*FY YGLWNLLCLST*RYHS*SSV**FSVWTTFPSNM LI*VAERTTN**TEF*HHIW*MSIL**ANYLKN VWKETLK*EYNISVKSWKLKKLSKGILVSSSEKK *SKKY*HQKDRYDDAIIINICVCLFTKSKLGNC RPKSS*TF*VCDPRADCGSVFIPRWRS*LLEYI WTGKILMRLIK*VWELCIADFLWETVYFIQRFLR LLIFLSSPCAFLWKKYIYSLVC*T*VIQVFILC SV*EC*IKCYTRS

Sequence FANCL.eAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGGTCACTGATCAAGCAAAAATGGATGTGAAAATTGCGGTTTTGCCTAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAA TAGAATCACTAAAGGCATTCTGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAG AATTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGGTATG ACATCTGAGATTTAAACGTTTTTTAATAGAGTCATAAAATCCTTGCCTAGCATTGTTAAATTATTAGACAATATTAGTATATTAATGGTAGTTTTTATTT TTTGTCTGAGACGGAGTTTTGCTCTTGTTGCCCAGTATGTAGTGTAATGGCGCGATCTCGGTTCACCGCAATAATGATAGTTATTTTAAATGACAATGTC TCAGCATTCTGAACTGTATAATTTTGTTTTTTAACATAATACATATAATTTTGATTTTCTAATCAAGTAGTTAAGAAACATTCTGTATCAAATGTGGCTT TAGAAACCAAGAGTAGAGCATGCAATTATTAAATTTTTTTTTTTTAATCTGAAGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTG GTAGGTACCTTGGCAATATAATTTTTACTTTTTGGTGATTTTACAAAGTTCACAGCATAATTTTTTTCCCCATGCTTTCAGGGATCCAGAAAATAGTGTG TTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGTAAGTTTTATCAGTGTTTTGATATTCCAGACAGTAT TGCATAATGAAGTTTAAATGCTTCTCTCAGTGAAAAATGAGGCTGAAAAAGGAGGGAATTAGAAAAATATTATAACACAGACTTCTGATCTGCATCAAAA AACTTGTTTACCTTTGATTGGTTGTTAAGTACAACTGTCTCTTGGAACAGGGGGATTGATTTCAGGGCTGCCCATGGATACAAAAATCCACAGACATTAA AGTTCCACAGTTACCCTGCAGGACCCATATATAGAAGAAGTCGGCCCTCTGTATACAGAGATTTCACATAAACACAGGTTCTGCATCTTGTCAGTACTGT ATTTTTGATCTGCATTTGGTTAAAAAAAAAATCTGTGTATAAGTAGACCTGTGCAGTTCAAACCCATGTTGTTCAAGGGTCAACTATATACTTTTTTCAT GGTCTTCAGTAGTGACGTCATTAATGACAGACATTTATTAAAAATAAGGGG

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Multiple exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQVTDQAKMDVKIAVLPSSLISIYSQFLAA IESLKAFWDVMDEIDEKTWVLEPEKPPRSATARR IALGNNVSINIEVDPRHPTMLPECFFLGADHGM TSEI*TFFNRVIKSLPSIVKLLDNISILMVVFI FCLRRSFALVAQYVV*WRDLGSPQ***LF*MTMS QHSELYNFVF*HNTYNFDFLIK*LRNILYQMWL *KPRVEHAIIKFFFFNLKW*NPWELS*AGTYIC GRYLGNIIFTFW*FYKVHSIIFFPMLSGIQKIVC YKI*KMF*KLIFQLVLSWKNL*VLSVF*YSRQY CIMKFKCFSQ*KMRLKKEGIRKIL*HRLLICIK KLVYL*LVVKYNCLLEQGD*FQGCPWIQKSTDIK VPQLPCRTHI*KKSALCIQRFHINTGSASCQYC IFDLHLVKKKICV*VDLCSSNPCCSRVNYILFS WSSVVTSLMTDIY*K*G

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLRSLIKQKWM*KLRFCLAP**AFIVSFWQQ *NH*RHSGMLWMKSMRRPGYLSQKNLHGVQQHA ELH*VIMFP*I*R*TPGILLCFLSASFLELTMV* HLRFKRFLIES*NPCLALLNY*TILVY*W*FLF FV*DGVLLLLPSM*CNGAISVHRNNDSYFK*QC LSILNCIILFFNIIHIILIF*SSS*ETFCIKCGF RNQE*SMQLLNFFFLI*SGKTPGN*AEQEHTFV VGTLAI*FLLFGDFTKFTA*FFSPCFQGSRK*C VTKFERCFRN*FSSSCYPGKICKFYQCFDIPDSI A**SLNASLSEK*G*KRRELEKYYNTDF*SASK NLFTFDWLLSTTVSWNRGIDFRAAHGYKNPQTL KFHSYPAGPIYRRSRPSVYRDFT*TQVLHLVSTV FLICIWLKKKSVYK*TCAVQTHVVQGSTIYFFH GLQ**RH**QTFIKNKG

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSGH*SSKNGCENCGFA*LLNKHL*SVFGSN RITKGILGCYG*NR*EDLGT*ARKTSTECNSTQ NCIR**CFHKYRGRPQASYYAS*VLLSWS*PWY DI*DLNVF**SHKILA*HC*IIRQY*YINGSFYF LSETEFCSCCPVCSVMARSRFTAIMIVILNDNV SAF*TV*FCFLT*YI*F*FSNQVVKKHSVSNVA LETKSRACNY*IFFF*SEVVKPLGIKLSRNIHLW *VPWQYNFYFLVILQSSQHNFFPHAFRDPENSV LQNLKDVLEIDFPARAILEKSVSFISVLIFQTV LHNEV*MLLSVKNEAEKGGN*KNIITQTSDLHQK TCLPLIGC*VQLSLGTGGLISGLPMDTKIHRH* SSTVTLQDPYIEEVGPLYTEISHKHRFCILSVL YF*SAFG*KKNLCISRPVQFKPMLFKGQLYTFFM VFSSDVINDRHLLKIR

Sequence FANCL.fAug05

CGAGCGCCAGCGGACTGCGCATGTGCAGGACCCAGCAGGTCTAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGT TGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTT GCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAG CACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCC AGTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGA TGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCC TCCTGGACACCTCAGGTAAATTCTCCTCAGAGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTA TGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCACGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAA TATAGAGGTAGACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATGGTATGACATCTGAGATTTAAACGTTTTTTAATAGA GTCATAAAATCCTTGCCTAGCATTGTTAAATTATTAGACAATATTAGTATATTAATGGTAGTTTTTATTTTTTGTCTGAGACGGAGTTTTGCTCTTGTTG CCCAGTATGTAGTGTAATGGCGCGATCTCGGTTCACCGCAATAATGATAGTTATTTTAAATGACAATGTCTCAGCATTCTGAACTGTATAATTTTGTTTT TTAACATAATACATATAATTTTGATTTTCTAATCAAGTAGTTAAGAAACATTCTGTATCAAATGTGGCTTTAGAAACCAAGAGTAGAGCATGCAATTATT AAATTTTTTTTTTTTAATCTGAAGTGGTAAAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGTAGGTACCTTGGCAATATAATTTTTACTT TTTGGTGATTTTACAAAGTTCACAGCATAATTTTTTTCCCCATGCTTTCAGGGATCCAGAAAATAGTGTGTTACAAAATTTGAAAGATGTTTTAGAAATT GATTTTCCAGCTCGTGCTATCCTGGAAAAATCTGTAAGTTTTATCAGTGTTTTGATATTCCAGACAGTATTGCATAATGAAGTTTAAATGCTTCTCTCAG TGAAAAATGAGGCTGAAAAAGGAGGGAATTAGAAAAATATTATAACACAGACTTCTGATCTGCATCAAAAAACTTGTTTACCTTTGATTGGTTGTTAAGT ACAACTGTCTCTTGGAACAGGGGGATTGATTTCAGGGCTGCCCATGGATACAAAAATCCACAGACATTAAAGTTCCACAGTTACCCTGCAGGACCCATAT ATAGAAGAAGTCGGCCCTCTGTATACAGAGATTTCACATAAACACAGGTTCTGCATCTTGTCAGTACTGTATTTTTGATCTGCATTTGGTTAAAAAAAAA ATCTGTGTATAAGTAGACCTGTGCAGTTCAAACCCATGTTGTTCAAGGGTCAACTATATACTTTTTTCATGGTCTTCAGTAGTGACGTCATTAATGACAG ACATTTATTAAAAATAAGGGG

FANCL.F9 (forward primer)
FANCL.R5 (reverse primer)
Multiple exon skipping

Frame 0

RAPADCACAGPSRSRAFLCFSGLRAMAVTEASL LRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVL PEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQ HSPDLMSFMMELKMLLEVALKNRQELYALPPPP QFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAED ASGREHLITLKLKAKYPAESPDYFVDFPVPFCA SWTPQVNSPQSSLISIYSQFLAAIESLKAFWDV MDEIDEKTWVLEPEKPPRSATARRIALGNNVSIN IEVDPRHPTMLPECFFLGADHGMTSEI*TFFNR VIKSLPSIVKLLDNISILMVVFIFCLRRSFALV AQYVV*WRDLGSPQ***LF*MTMSQHSELYNFVF *HNTYNFDFLIK*LRNILYQMWL*KPRVEHAII KFFFFNLKW*NPWELS*AGTYICGRYLGNIIFT FW*FYKVHSIIFFPMLSGIQKIVCYKI*KMF*KL IFQLVLSWKNL*VLSVF*YSRQYCIMKFKCFSQ *KMRLKKEGIRKIL*HRLLICIKKLVYL*LVVK YNCLLEQGD*FQGCPWIQKSTDIKVPQLPCRTHI *KKSALCIQRFHINTGSASCQYCIFDLHLVKKK ICV*VDLCSSNPCCSRVNYILFSWSSVVTSLMT DIY*K*G

Frame 1

ERQRTAHVQDPAGLELFCVSPDFEPWR*RKRAC CASAPCFCPRTGRKPCMRDSSRLREETSTLG*C CLKIYN*RMQDYYVVGS*EQYLVDTIE*YNRECS TLLI**AL*WS*RCFWKLP*RIDKSCMHYLLLP SSTQALLKR*ELLVGINLCMRIPASVPSS*KQK MLLVESI*SLSS*RQSILQNHQIILWIFLFHFVP PGHLR*ILLRAP**AFIVSFWQQ*NH*RHSGML WMKSMRRPGYLSQKNLHGVQQHAELH*VIMFP* I*R*TPGILLCFLSASFLELTMV*HLRFKRFLIE S*NPCLALLNY*TILVY*W*FLFFV*DGVLLLL PSM*CNGAISVHRNNDSYFK*QCLSILNCIILF FNIIHIILIF*SSS*ETFCIKCGFRNQE*SMQLL NFFFLI*SGKTPGN*AEQEHTFVVGTLAI*FLL FGDFTKFTA*FFSPCFQGSRK*CVTKFERCFRN *FSSSCYPGKICKFYQCFDIPDSIA**SLNASLS EK*G*KRRELEKYYNTDF*SASKNLFTFDWLLS TTVSWNRGIDFRAAHGYKNPQTLKFHSYPAGPI YRRSRPSVYRDFT*TQVLHLVSTVFLICIWLKKK SVYK*TCAVQTHVVQGSTIYFFHGLQ**RH**Q TFIKNKG

Frame 2

SASGLRMCRTQQV*SFSVFLRTSSHGGDGSEPV APVPPASAPEPVENRV*GIHLGSGKRLPP*DSV A*RFTTEECKIIM*LAAENNT*WIPSNSTTENA ALS*SNELYDGVEDAFGSCLKE*TRAVCTTSSSP VLLKPY*RDRNSWLG*TCVCGYLLQYHQVKSRR CFW*RAFNHSQVEGKVSCRITRLFCGFSCSILC LLDTSGKFSSELLNKHL*SVFGSNRITKGILGCY G*NR*EDLGT*ARKTSTECNSTQNCIR**CFHK YRGRPQASYYAS*VLLSWS*PWYDI*DLNVF** SHKILA*HC*IIRQY*YINGSFYFLSETEFCSCC PVCSVMARSRFTAIMIVILNDNVSAF*TV*FCF LT*YI*F*FSNQVVKKHSVSNVALETKSRACNY *IFFF*SEVVKPLGIKLSRNIHLW*VPWQYNFYF LVILQSSQHNFFPHAFRDPENSVLQNLKDVLEI DFPARAILEKSVSFISVLIFQTVLHNEV*MLLS VKNEAEKGGN*KNIITQTSDLHQKTCLPLIGC*V QLSLGTGGLISGLPMDTKIHRH*SSTVTLQDPY IEEVGPLYTEISHKHRFCILSVLYF*SAFG*KK NLCISRPVQFKPMLFKGQLYTFFMVFSSDVINDR HLLKIR