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Sequences

Sequence FANCA.eAug05

GAGGACCATGTGTGGACGTGTGCTCCCTGCAGTGCTCACCCGGCTCTGCCAGCTGCTCCGTCACCAGGTGAGGCTCTCCTTCATGGGGGCCACCCTTGGG GGCCCACTCTGAGGGCCAGGCTGCTACTTCTCAATTCGTCTTCAGTGCCCTGGAAAATTCCAGCTTGGAAGAGGGCAGTCTGCTCTGCCACCCTCATTCT CGTTGCAGGGCCCGAGCCTGAGTGCCCCACATGTGCTGGGGTTGGCTGCCCTGGCCGTGCACCTGGGTGAGTCCAGGTCTGCGCTCCCAGAGGTGGATGT GGGTCCTCCTGCACCTGGTGCTGGCCTTCCTGTCCCTGCGCTCTTTGACAGCCTCCTGACCTGTAGGACGAGGGATTCCTTGTTCTTCTGCCTGAAATTT TGTACAGCAGCAATTTCTTACTCTCTCTGCAAGTTTTCTTCCCAGTCACGAGATACTTTGTGCAGCTGCTTATCTCCAGGCCTTATTAAAAAGTTTCAGT TCCTCATGTTCAGATTGTTCTCAGAGGCCCGACAGCCTCTTTCTGAGGAGGACGTAGCCAGCCTTTCCTGGAGACCCTTGCACCTTCCTTCTGCAGACTG GCAGAGAGCTGCCCTCTCTCTCTGGACACACAGAACCTTCCGAGAGGTGTTGAAAGAGGAAGATGTTCACTTAACTTACCAAGACTGGTTACACCTGGAG CTGGAAATTCAACCTGAAGCTGATGCTCTTTCAGATACTGAACGGCAGGACTTCCACCAGTGGGCGATCCATGAGCACTTTCTCCCTGAGTCCTCGGCTT CAGGGGGCTGTGACGGAGACCTGCAGGCTGCGTGTACCATTCTTGTCAACGCACTGATGGATTTCCACCAAAGGAGATGGTAGCTGACCTGGAGCTGCAG CAAGACCTCATAGTGCCTCTCGGCCACACCCCTTCCCAGGAGCACTTCCTCTTTGAGATTTTCCGCAGACGGCTCCAGGCTCTGACAAGCGGGTGGAGCG TGGCTGCCAGCCTTCAGAGACAGAGGGAGCTGCTAATGTACAAACGGATCCTCCTCCGCCTGCCTTCGTCTGTCCTCTGCGGCAGCAGCTTCCAGGCAGA ACAGCCCATCACTGCCAGATGCGAGCAGTTCTTCCACTTGGTCAACTCTGAGATGAGAAACTTCTGCTCCCACGGAGGTGCCCTGACACAGGACATCACT GCCCACTTCTTCAGGGGCCTCCTGAACGCCTGTCTGCGGAGCAGAGACCCCTCCCTGATGGTCGACTTCATACTGGCCAAGTGCCAGACGAAATGCCCCT TAATTTTGACCTCTGCTCTGGTGTGGTGGCCGAGCCTGGAGCCTGTGCTGCTCTGCCGGTGGAGGAGACACTGCCAGAGCCCGCTGCCCCGGGAACTGCA GAAGCTACAAGAAGGCCGGCAGTTTGCCAGCGAGTACGTGTGGGTGGTGAGATGGGGTGTGCCCGCCCAGATGCACTTCGGGACCTGCTCAAGGTCATCT CCTAAACACCCTGGCTTGCTTGAGAGAAGCGGTGTGGGCAGCCTCTCGTGTGAGCAGGGAGAAAAGAACCGAGTTCTCGTGGTGGTGGGCGCCTGTAATC CCAACTACTGGGGAGGCCGAGGCAGGAGAATCAGTTGAACCCAGGAGGTGGAGTTTCCAGTGAGCCGAGATCACTCCAACGGCCAATAGAGCAAGACTCT GTCCA

FANCA.F13 (forward primer)
FANCA.R12 (reverse primer)
Single exon skipping

Frame 0

EDHVWTCAPCSAHPALPAAPSPGEALLHGGHPW GPTLRARLLLLNSSSVPWKIPAWKRAVCSATLIL VAGPEPECPTCAGVGCPGRAPG*VQVCAPRGGC GSSCTWCWPSCPCAL*QPPDL*DEGFLVLLPEI LYSSNFLLSLQVFFPVTRYFVQLLISRPY*KVSV PHVQIVLRGPTASF*GGRSQPFLETLAPSFCRL AESCPLSLDTQNLPRGVERGRCSLNLPRLVTPG AGNST*S*CSFRY*TAGLPPVGDP*ALSP*VLGF RGL*RRPAGCVYHSCQRTDGFPPKEMVADLELQ QDLIVPLGHTPSQEHFLFEIFRRRLQALTSGWS VAASLQRQRELLMYKRILLRLPSSVLCGSSFQAE QPITARCEQFFHLVNSEMRNFCSHGGALTQDIT AHFFRGLLNACLRSRDPSLMVDFILAKCQTKCP LILTSALVWWPSLEPVLLCRWRRHCQSPLPRELQ KLQEGRQFASEYVWVVRWGVPAQMHFGTCSRSS PKHPGLLERSGVGSLSCEQGEKNRVLVVVGACN PNYWGGRGRRIS*TQEVEFPVSRDHSNGQ*SKTL S

Frame 1

RTMCGRVLPAVLTRLCQLLRHQVRLSFMGATLG GPL*GPGCYFSIRLQCPGKFQLGRGQSALPPSF SLQGPSLSAPHVLGLAALAVHLGESRSALPEVDV GPPAPGAGLPVPALFDSLLTCRTRDSLFFCLKF CTAAISYSLCKFSSQSRDTLCSCLSPGLIKKFQ FLMFRLFSEARQPLSEEDVASLSWRPLHLPSADW QRAALSLWTHRTFREVLKEEDVHLTYQDWLHLE LEIQPEADALSDTERQDFHQWAIHEHFLPESSA SGGCDGDLQAACTILVNALMDFHQRRW*LTWSCS KTS*CLSATPLPRSTSSLRFSADGSRL*QAGGA WLPAFRDRGSC*CTNGSSSACLRLSSAAAASRQ NSPSLPDASSSSTWSTLR*ETSAPTEVP*HRTSL PTSSGAS*TPVCGAETPP*WSTSYWPSARRNAP *F*PLLWCGGRAWSLCCSAGGGDTARARCPGNC RSYKKAGSLPASTCGW*DGVCPPRCTSGPAQGHL LNTLACLREAVWAASRVSREKRTEFSWWWAPVI PTTGEAEAGESVEPRRWSFQ*AEITPTANRARL CP

Frame 2

GPCVDVCSLQCSPGSASCSVTR*GSPSWGPPLG AHSEGQAATSQFVFSALENSSLEEGSLLCHPHS RCRARA*VPHMCWGWLPWPCTWVSPGLRSQRWM WVLLHLVLAFLSLRSLTAS*PVGRGIPCSSA*NF VQQQFLTLSASFLPSHEILCAAAYLQALLKSFS SSCSDCSQRPDSLFLRRT*PAFPGDPCTFLLQT GRELPSLSGHTEPSERC*KRKMFT*LTKTGYTWS WKFNLKLMLFQILNGRTSTSGRSMSTFSLSPRL QGAVTETCRLRVPFLSTH*WISTKGDGS*PGAA ARPHSASRPHPFPGALPL*DFPQTAPGSDKRVER GCQPSETEGAANVQTDPPPPAFVCPLRQQLPGR TAHHCQMRAVLPLGQL*DEKLLLPRRCPDTGHH CPLLQGPPERLSAEQRPLPDGRLHTGQVPDEMPL NFDLCSGVVAEPGACAALPVEETLPEPAAPGTA EATRRPAVCQRVRVGGEMGCARPDALRDLLKVI S*TPWLA*EKRCGQPLV*AGRKEPSSRGGGRL*S QLLGRPRQENQLNPGGGVSSEPRSLQRPIEQDS V

Sequence FANCA.aAug05

CGGGCGCAGGGAGCCGCCGCCGGGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGGGGCCGCCGGA GGGCCTGGGCCGAGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCAGCTGTGCGCCTCCTGCGAAG CCATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAAGTGATTGACTGTGACAGTTCTGAGGCCTAT GCTAATCATTCTAGTTCATTTATAGGCTCTGCTTTGCAGGATCAAGCCTCAAGGCTGGGGGTTCCCGTGGGTATTCTCTCAGCCGGGATGGTTGCCTCTA GCGTGGGACAGATCTGCACGGCTCCAGCGGAGACCAGTCACCCTGTGCTGCTGACTGTGGAGCAGAGAAAGAAGCTGTCTTCCCTGTTAGAGTTTGCTCA GTATTTATTGGCACACAGTATGTTCTCCCGTCTTTCCTTCTGTCAAGAATTATGGAAAATACAGAGTTCTTTGTTGCTTGAAGCGGTGTGGCATCTTCAC GTACAAGGCATTGTGAGCCTGCAAGAGCTGCTGGAAAGCCATCCCGACATGCATGCTGTGGGATCGTGGCTCTTCAGGAATCTGTGCTGCCTTTGTGAAC AGATGGAAGCATCCTGCCAGCATGCTGACGTCGCCAGGGCCATGCTTTCTGATTTTGTTCAAATGTTTGTTTTGAGGGGATTTCAGAAAAACTCAGATCT GAGAAGAACTGTGGAGCCTGAAAAAATGCCGCAGGTCACGGTTGATGTACTGCAGAGAATGCTGATTTTTGCACTTGACGCTTTGGCTGCTGGAGTACAG GAGGAGTCCTCCACTCACAAGATCGTGAGGTGCTGGTTCGGAGTGTTCAGTGGACACACGCTTGGCAGTGTAATTTCCACAGATCCTCTGAAGAGGTTCT TCAGTCATACCCTGACTCAGATACTCACTCACAGCCCTGTGCTGAAAGCATCTGATGCTGTTCAGATGCAGAGAGAGTGGAGCTTTGCGCGGACACACCC TCTGCTCACCTCACTGTACCGCAGGCTCTTTGTGATGCTGAGTGCAGAGGAGTTGGTTGGCCATTTGCAAGAAGTTCTGGAAACGCAGGAGGTTCACTGG CAGAGAGTGCTCTCCTTTGTGTCTGCCCTGGTTGTCTGCTTTCCAGAAGCGCAGCAGCTGCTTGAAGACTGGGTGGCGCGTTTGATGGCCCAGGCATTCG AGAGCTGCCAGCTGGACAGCATGGTCACTGCGTTCCTGGTTGTGCGCCAGGCAGCACTGGAGGGCCCCTCTGCGTTCCTGTCATATGCAGACTGGTTCAA GGCCTCCTTTGGGAGCACACGAGGCTACCATGGCTGCAGCAAGAAGGCCCTGGTCTTCCTGTTTACGTTCTTGTCAGAACTCGTGCCTTTTGAGTCTCCC CGGTACCTGCAGGTGCACATTCTCCACCCACCCCTGGTTCCCGGCAAGTACCGCTCCCTCCTCACAGACTACATCTCATTGGCCAAGACACGGCTGGCCG ACCTCAAGGTTTCTATAGAAAACATGGGACTCTACGAGGATTTGTCATCAGCTGGGGACATTACTGAGCCCCACAGCCAAGCTCTTCAGGATGTTGAAAA GGCCATCATGGTGTTTGAGCATACGGGGAACATCCCAGTCACCGTCATGGAGGCCAGCATATTCAGGAGGCCTTACTACGTGTCCCACTTCCTCCCCGCC CTGCTCACACCTCGAGTGCTCCCCAAAGTCCCTGACTCCCGTGTGGCGTTTATAGAGTCTCTGAAGAGAGCAGATAAAATCCCCCCATCTCTGTACTCCA CCTACTGCCAGGCCTGCTCTGCTGCTGAAGAGAAGCCAGAAGATGCAGCCCTGGGAGTGAGGGCAGAACCCAACTCTGCTGAGGAGCCCCTGGGACAGCT CACAGCTGCACTGGGAGAGCTGAGAGCCTCCATGACAGACCCCAGCCAGCGTGATGTTATATCGGCACAGGTGGCAGTGATTTCTGAAAGACTGAGGGCT GTCCTGGGCCACAATGAGGATGACAGCAGCGTTGAGATATCAAAGATTCAGCTCAGCATCAACACGCCGAGACTGGAGCCACGGGAACACATGGCTGTGG ACCTCCTGCTGACGTCTTTCTGTCAGAACCTGATGGCTGCCTCCAGTGTCGCTCCCCCGGAGAGGCAGGGTCCCTGGGCTGCCCTCTTCGTGAGGACCAT GTGTGGACGTGTGCTCCCTGCAGTGCTCACCCGGCTCTGCCAGCTGCTCCGTCACCAGGGCCCGAGCCTGAGTGCCCCACATGTGCTGGGGTTGGCTGCC CTGGCCGTGCACCTGGGTGAGTCCAGGTCTGCGCTCCCAGAGGTGGATGTGGGTCCTCCTGCACCTGGTGCTGGCCTTCCTGTCCCTGCGCTCTTTGACA GCCTCCTGACCTGTAGGACGAGGGATTCCTTGTTCTTCTGCCTGAAATTTTGTACAGCAGCAATTTCTTACTCTCTCTGCAAGTTTTCTTCCCAGTCACG AGATACTTTGTGCAGCTGCTTATCTCCAGGCCTTATTAAAAAGTTTCAGTTCCTCATGTTCAGATTGTTCTCAGAGGCCCGACAGCCTCTTTCTGAGGAG GACGTAGCCAGCCTTTCCTGGAGACCCTTGCACCTTCCTTCTGCAGACTGGCAGAGAGCTGCCCTCTCTCTCTGGACACACAGAACCTTCCGAGAGGTGT TGAAAGAGGAAGATGTTCACTTAACTTACCAAGACTGGTTACACCTGGAGCTGGAAATTCAACCTGAAGCTGATGCTCTTTCAGATACTGAACGGCAGGA CTTCCACCAGTGGGCGATCCATGAGCACTTTCTCCCTGAGTCCTCGGCTTCAGGGGGCTGTGACGGAGACCTGCAGGCTGCGTGTACCATTCTTGTCAAC GCACTGATGGATTTCCACCAAAGCTCAAGGAGTTATGACCACTCAGAAAATTCTGATTTGGTCTTTGGTGGCCGCACAGGAAATGAGGATATTATTTCCA GATTGCAGGAGATGGTAGCTGACCTGGAGCTGCAGCAAGACCTCATAGTGCCTCTCGGCCACACCCCTTCCCAGGAGCACTTCCTCTTTGAGATTTTCCG CAGACGGCTCCAGGCTCTGACAAGCGGGTGGAGCGTGGCTGCCAGCCTTCAGAGACAGAGGGAGCTGCTAATGTACAAACGGATCCTCCTCCGCCTGCCT TCGTCTGTCCTCTGCGGCAGCAGCTTCCAGGCAGAACAGCCCATCACTGCCAGATGCGAGCAGTTCTTCCACTTGGTCAACTCTGAGATGAGAAACTTCT GCTCCCACGGAGGTGCCCTGACACAGGACATCACTGCCCACTTCTTCAGGGGCCTCCTGAACGCCTGTCTGCGGAGCAGAGACCCCTCCCTGATGGTCGA CTTCATACTGGCCAAGTGCCAGACGAAATGCCCCTTAATTTTGACCTCTGCTCTGGTGTGGTGGCCGAGCCTGGAGCCTGTGCTGCTCTGCCGGTGGAGG AGACACTGCCAGAGCCCGCTGCCCCGGGAACTGCAGAAGCTACAAGAAGGCCGGCAGTTTGCCAGCGATTTCCTCTCCCCTGAGGCTGCCTCCCCAGCAC CCAACCCGGACTGGCTCTCAGCTGCTGCACTGCACTTTGCGATTCAACAAGTCAGGGAAGAAAACATCAGGAAGCAGCTAAAGAAGCTGGACTGCGAGAG AGAGGAGCTATTGGTTTTCCTTTTCTTCTTCTCCTTGATGGGCCTGCTGTCGTCACATCTGACCTCAAATAGCACCACAGACCTGCCAAAGGCTTTCCAC GTTTGTGCAGCAATCCTCGAGTGTTTAGAGAAGAGGAAGATATCCTGGCTGGCACTCTTTCAGTTGACAGAGAGTGACCTCAGGCTGGGGCGGCTCCTCC TCCGTGTGGCCCCGGATCAGCACACCAGGCTGCTGCCTTTCGCTTTTTACAGTCTTCTCTCCTACTTCCATGAAGACGCGGCCATCAGGGAAGAGGCCTT CCTGCATGTTGCTGTGGACATGTACTTGAAGCTGGTCCAGCTCTTCGTGGCTGGGGATACAAGCACAGTTTCACCTCCAGCTGGCAGGAGCCTGGAGCTC AAGGGTCAGGGCAACCCCGTGGAACTGATAACAAAAGCTCGTCTTTTTCTGCTGCAGTTAATACCTCGGTGCCCGAAAAAGAGCTTCTCACACGTGGCAG AGCTGCTGGCTGATCGTGGGGACTGCGACCCAGAGGTGAGCGCCGCCCTCCAGAGCAGACAGCAGGCTGCCCCTGACGCTGACCTGTCCCAGGAGCCTCA TCTCTTCTGACGGGACCTGCCACTGCACACCAGCCCAGCTCCCGTGTAAATAATTTATTACAAGCATAACATGGAGCTCTTGTTGCACTAAAAAGTGGAT TACAAATCTCCTCGACTGCTTTAGTGGGGAAAGGAATCAATTATTTATGAACTGTCCGGCCCCGAGTCACTCAGCGTTTGCGGGAAAATAAACCACTGGT CCCAGAGCAGAGGAAGGCTACTTGAGCCGGACACCAAGCCCGCCTCCAGCACCAAGGGCGGGCAGCACCCTCCGACCCTCCCATGCGGGTGCACACGAAG GGTGAGGCTGACACAGCCACTGCGGAGTCCAGGCTGCTAGAGGTGCTCATCCTCACTGCCGTCCTCAGGTGGGTTCGGGCTTCACCGCCTGGCCCTCTGT GGTCACAGAGGGGCTCGGTGGCCCAGGTGGTGGTTCCGCCTCCAGGGGCAGGGCCTTGTCCTGGGTCTGTGTCAGCGGGTGCACCATGGACATGTGTACA TTGAGGTTGTGGGCCTTCTCAAACCGCCGGCCACACTGGTCACAGGCAAAGTCCAGCTCAGTCTCAGCCTTGTGTTTGGTCATGTGGTACTTGAGGGATG CCCGCTGCCTGCACTGGAACCCACAGACCTCACACCTGGGGGACAGAGGCAGATAAGAAGGTGCGAGGGCCACAGCCCTGGGAGGGGGTCCTGACTCACA CTTACTGCAAAGGCTTGGCTCCCGAATGTCGCATTTGGTGGACGAGAAGGTGCTTCCGCTGCTTGAAGGTTTGTCCACATTCGTCACAGATATAGTTCCG CACCTCTGAGAGGGGAGAGTCCAGTGAGTCCAGGCCCCTGATGCTCCAACCTCCCGGGGGGACGACGATGACAATGTGAAACCATCACAGCTGGGAAGAC ATTTCTGCACATGGTTCACCATGCAGTGGGCCCAAGCAAGGGGCCTATGAGGGCCTCGTTTATTAAGATCTTTAAACTGCTTTATACACTGTCACGTGGC TTCATCAGCTGTGTGCATTTCAGGATGGTTTTTAAAGAAACCTCAGAAAGCTATTTCCTT

FANCA.F13 (forward primer)
FANCA.R12 (reverse primer)
Single exon skipping

Frame 0

RAQGAAAGAVGAKAMSDSWVPNSASGQDPGGRR RAWAELLAGRVKREKYNPERAQKLKESAVRLLRS HQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAY ANHSSSFIGSALQDQASRLGVPVGILSAGMVAS SVGQICTAPAETSHPVLLTVEQRKKLSSLLEFAQ YLLAHSMFSRLSFCQELWKIQSSLLLEAVWHLH VQGIVSLQELLESHPDMHAVGSWLFRNLCCLCE QMEASCQHADVARAMLSDFVQMFVLRGFQKNSDL RRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQ EESSTHKIVRCWFGVFSGHTLGSVISTDPLKRF FSHTLTQILTHSPVLKASDAVQMQREWSFARTHP LLTSLYRRLFVMLSAEELVGHLQEVLETQEVHW QRVLSFVSALVVCFPEAQQLLEDWVARLMAQAF ESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFK ASFGSTRGYHGCSKKALVFLFTFLSELVPFESP RYLQVHILHPPLVPGKYRSLLTDYISLAKTRLA DLKVSIENMGLYEDLSSAGDITEPHSQALQDVEK AIMVFEHTGNIPVTVMEASIFRRPYYVSHFLPA LLTPRVLPKVPDSRVAFIESLKRADKIPPSLYS TYCQACSAAEEKPEDAALGVRAEPNSAEEPLGQL TAALGELRASMTDPSQRDVISAQVAVISERLRA VLGHNEDDSSVEISKIQLSINTPRLEPREHMAV DLLLTSFCQNLMAASSVAPPERQGPWAALFVRTM CGRVLPAVLTRLCQLLRHQGPSLSAPHVLGLAA LAVHLGESRSALPEVDVGPPAPGAGLPVPALFD SLLTCRTRDSLFFCLKFCTAAISYSLCKFSSQSR DTLCSCLSPGLIKKFQFLMFRLFSEARQPLSEE DVASLSWRPLHLPSADWQRAALSLWTHRTFREV LKEEDVHLTYQDWLHLELEIQPEADALSDTERQD FHQWAIHEHFLPESSASGGCDGDLQAACTILVN ALMDFHQSSRSYDHSENSDLVFGGRTGNEDIIS RLQEMVADLELQQDLIVPLGHTPSQEHFLFEIFR RRLQALTSGWSVAASLQRQRELLMYKRILLRLP SSVLCGSSFQAEQPITARCEQFFHLVNSEMRNF CSHGGALTQDITAHFFRGLLNACLRSRDPSLMVD FILAKCQTKCPLILTSALVWWPSLEPVLLCRWR RHCQSPLPRELQKLQEGRQFASDFLSPEAASPA PNPDWLSAAALHFAIQQVREENIRKQLKKLDCER EELLVFLFFFSLMGLLSSHLTSNSTTDLPKAFH VCAAILECLEKRKISWLALFQLTESDLRLGRLL LRVAPDQHTRLLPFAFYSLLSYFHEDAAIREEAF LHVAVDMYLKLVQLFVAGDTSTVSPPAGRSLEL KGQGNPVELITKARLFLLQLIPRCPKKSFSHVA ELLADRGDCDPEVSAALQSRQQAAPDADLSQEPH LF*RDLPLHTSPAPV*IIYYKHNMELLLH*KVD YKSPRLL*WGKESIIYELSGPESLSVCGKINHW SQSRGRLLEPDTKPASSTKGGQHPPTLPCGCTRR VRLTQPLRSPGC*RCSSSLPSSGGFGLHRLALC GHRGARWPRWWFRLQGQGLVLGLCQRVHHGHVY IEVVGLLKPPATLVTGKVQLSLSLVFGHVVLEGC PLPALEPTDLTPGGQRQIRRCEGHSPGRGS*LT LTAKAWLPNVAFGGREGASAA*RFVHIRHRYSS APLRGESPVSPGP*CSNLPGGRR*QCETITAGKT FLHMVHHAVGPSKGPMRASFIKIFKLLYTLSRG FISCVHFRMVFKETSESYFL

Frame 1

GRREPPPGL*APRPCPTRGSRTPPRARTQGAAG GPGPSCWREGSRGKNIILKGHRN*RNQLCASCE AIRT*MPFCLR*KVHCVKNCLSAK*LTVTVLRPM LIILVHL*ALLCRIKPQGWGFPWVFSQPGWLPL AWDRSARLQRRPVTLCC*LWSRERSCLPC*SLL SIYWHTVCSPVFPSVKNYGKYRVLCCLKRCGIFT YKAL*ACKSCWKAIPTCMLWDRGSSGICAAFVN RWKHPASMLTSPGPCFLILFKCLF*GDFRKTQI *EELWSLKKCRRSRLMYCREC*FLHLTLWLLEYR RSPPLTRS*GAGSECSVDTRLAV*FPQIL*RGS SVIP*LRYSLTALC*KHLMLFRCRESGALRGHT LCSPHCTAGSL*C*VQRSWLAICKKFWKRRRFTG RECSPLCLPWLSAFQKRSSCLKTGWRV*WPRHS RAASWTAWSLRSWLCARQHWRAPLRSCHMQTGS RPPLGAHEATMAAARRPWSSCLRSCQNSCLLSLP GTCRCTFSTHPWFPASTAPSSQTTSHWPRHGWP TSRFL*KTWDSTRICHQLGTLLSPTAKLFRMLK RPSWCLSIRGTSQSPSWRPAYSGGLTTCPTSSPP CSHLECSPKSLTPVWRL*SL*REQIKSPHLCTP PTARPALLLKRSQKMQPWE*GQNPTLLRSPWDS SQLHWES*EPP*QTPASVMLYRHRWQ*FLKD*GL SWATMRMTAALRYQRFSSASTRRDWSHGNTWLW TSC*RLSVRT*WLPPVSLPRRGRVPGLPSS*GP CVDVCSLQCSPGSASCSVTRARA*VPHMCWGWLP WPCTWVSPGLRSQRWMWVLLHLVLAFLSLRSLT AS*PVGRGIPCSSA*NFVQQQFLTLSASFLPSH EILCAAAYLQALLKSFSSSCSDCSQRPDSLFLRR T*PAFPGDPCTFLLQTGRELPSLSGHTEPSERC *KRKMFT*LTKTGYTWSWKFNLKLMLFQILNGR TSTSGRSMSTFSLSPRLQGAVTETCRLRVPFLST H*WISTKAQGVMTTQKILIWSLVAAQEMRILFP DCRRW*LTWSCSKTS*CLSATPLPRSTSSLRFS ADGSRL*QAGGAWLPAFRDRGSC*CTNGSSSACL RLSSAAAASRQNSPSLPDASSSSTWSTLR*ETS APTEVP*HRTSLPTSSGAS*TPVCGAETPP*WS TSYWPSARRNAP*F*PLLWCGGRAWSLCCSAGGG DTARARCPGNCRSYKKAGSLPAISSPLRLPPQH PTRTGSQLLHCTLRFNKSGKKTSGSS*RSWTAR ERSYWFSFSSSP*WACCRHI*PQIAPQTCQRLST FVQQSSSV*RRGRYPGWHSFS*QRVTSGWGGSS SVWPRISTPGCCLSLFTVFSPTSMKTRPSGKRP SCMLLWTCT*SWSSSSWLGIQAQFHLQLAGAWSS RVRATPWN**QKLVFFCCS*YLGARKRASHTWQ SCWLIVGTATQR*APPSRADSRLPLTLTCPRSL ISSDGTCHCTPAQLPCK*FITSITWSSCCTKKWI TNLLDCFSGERNQLFMNCPAPSHSAFAGK*TTG PRAEEGYLSRTPSPPPAPRAGSTLRPSHAGAHE G*G*HSHCGVQAARGAHPHCRPQVGSGFTAWPSV VTEGLGGPGGGSASRGRALSWVCVSGCTMDMCT LRLWAFSNRRPHWSQAKSSSVSALCLVMWYLRD ARCLHWNPQTSHLGDRGR*EGARATALGGGPDSH LLQRLGSRMSHLVDEKVLPLLEGLSTFVTDIVP HL*EGRVQ*VQAPDAPTSRGDDDDNVKPSQLGR HFCTWFTMQWAQARGL*GPRLLRSLNCFIHCHVA SSAVCISGWFLKKPQKAIS

Frame 2

GAGSRRRGCRRQGHVRLVGPELRLGPGPRGPPE GLGRAAGGKGQEGKI*S*KGTEIKGISCAPPAK PSGPECPFA*GRRSTV*KIVSQQSD*L*QF*GL C*SF*FIYRLCFAGSSLKAGGSRGYSLSRDGCL* RGTDLHGSSGDQSPCAADCGAEKEAVFPVRVCS VFIGTQYVLPSFLLSRIMENTEFFVA*SGVASS RTRHCEPARAAGKPSRHACCGIVALQESVLPL*T DGSILPAC*RRQGHAF*FCSNVCFEGISEKLRS EKNCGA*KNAAGHG*CTAENADFCT*RFGCWST GGVLHSQDREVLVRSVQWTHAWQCNFHRSSEEVL QSYPDSDTHSQPCAESI*CCSDAERVELCADTP SAHLTVPQALCDAECRGVGWPFARSSGNAGGSL AESALLCVCPGCLLSRSAAAA*RLGGAFDGPGIR ELPAGQHGHCVPGCAPGSTGGPLCVPVICRLVQ GLLWEHTRLPWLQQEGPGLPVYVLVRTRAF*VS PVPAGAHSPPTPGSRQVPLPPHRLHLIGQDTAGR PQGFYRKHGTLRGFVISWGHY*APQPSSSGC*K GHHGV*AYGEHPSHRHGGQHIQEALLRVPLPPR PAHTSSAPQSP*LPCGVYRVSEESR*NPPISVLH LLPGLLCC*REARRCSPGSEGRTQLC*GAPGTA HSCTGRAESLHDRPQPA*CYIGTGGSDF*KTEG CPGPQ*G*QQR*DIKDSAQHQHAETGATGTHGCG PPADVFLSEPDGCLQCRSPGEAGSLGCPLREDH VWTCAPCSAHPALPAAPSPGPEPECPTCAGVGC PGRAPG*VQVCAPRGGCGSSCTWCWPSCPCAL*Q PPDL*DEGFLVLLPEILYSSNFLLSLQVFFPVT RYFVQLLISRPY*KVSVPHVQIVLRGPTASF*G GRSQPFLETLAPSFCRLAESCPLSLDTQNLPRGV ERGRCSLNLPRLVTPGAGNST*S*CSFRY*TAG LPPVGDP*ALSP*VLGFRGL*RRPAGCVYHSCQ RTDGFPPKLKEL*PLRKF*FGLWWPHRK*GYYFQ IAGDGS*PGAAARPHSASRPHPFPGALPL*DFP QTAPGSDKRVERGCQPSETEGAANVQTDPPPPA FVCPLRQQLPGRTAHHCQMRAVLPLGQL*DEKLL LPRRCPDTGHHCPLLQGPPERLSAEQRPLPDGR LHTGQVPDEMPLNFDLCSGVVAEPGACAALPVE ETLPEPAAPGTAEATRRPAVCQRFPLP*GCLPST QPGLALSCCTALCDSTSQGRKHQEAAKEAGLRE RGAIGFPFLLLLDGPAVVTSDLK*HHRPAKGFP RLCSNPRVFREEEDILAGTLSVDRE*PQAGAAPP PCGPGSAHQAAAFRFLQSSLLLP*RRGHQGRGL PACCCGHVLEAGPALRGWGYKHSFTSSWQEPGA QGSGQPRGTDNKSSSFSAAVNTSVPEKELLTRGR AAG*SWGLRPRGERRPPEQTAGCP*R*PVPGAS SLLTGPATAHQPSSRVNNLLQA*HGALVALKSG LQISSTALVGKGINYL*TVRPRVTQRLRENKPLV PEQRKAT*AGHQARLQHQGRAAPSDPPMRVHTK GEADTATAESRLLEVLILTAVLRWVRASPPGPL WSQRGSVAQVVVPPPGAGPCPGSVSAGAPWTCVH *GCGPSQTAGHTGHRQSPAQSQPCVWSCGT*GM PAACTGTHRPHTWGTEADKKVRGPQPWEGVLTH TYCKGLAPECRIWWTRRCFRCLKVCPHSSQI*FR TSERGESSESRPLMLQPPGGTTMTM*NHHSWED ISAHGSPCSGPKQGAYEGLVY*DL*TALYTVTW LHQLCAFQDGF*RNLRKLFP