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Sequences

Sequence ADAM15.oAug05

TTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTAGGACCCAGC
CTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGGCAGTGATGT
GGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGGGCACAGGAA
TGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTCAGCTCAAAG
CAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCGCCTGCACCA
GCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTGCTGGCACGA
GGCACTAAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGTGGTGCTCTTCATTAGGTG
ATCGGGGTGCCCCTCAGCCTTCAGACACTCTGAGCCCCAGAAGCAGCAAAGGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCC
GACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAG
TGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATG
ACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGG
CTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA
  • ADAM15.F1 (forward primer)
  • ADAM15.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQ
PLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDV
AQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQE
CRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLK
ATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ
RLCQLKGPTCQYRAAQSGPSERPGPPQRALLAR
GTKASALSFPAPPSRPLPPDPVSKRLQWCSSLG
DRGAPQPSDTLSPRSSKGLRGQPSPHPQGSHCLP
TPRAGAHRVTCPAQGLESRP*WYPPDQRHRLRQ
CPRSTSDLSGGSAASKPDLGLQEAGVPSGVPYH
D*RRQRLAVS*DSGHRHALSSNTLRTCRRSCSGG
LGRGWGLDGIEEGPHSLSLLSCNKRDILGAFPR

Frame 1

LGAVGATPVAVMCPAPLEMPFVGSSSARQVGPS
LCWAPSGIYSGRQ*M*MGLS*TAAGCTWTWAVM
WPSPS*LCLAQPVALAWCV*TIDASVWISWGHRN
VEANAMDMGSVTATGTATVRRAGHPLTAPLSSK
QPAP*PQGCSSASWSYWSW*CLVPATGTVPACT
SDSASSRDPPASTGQPNLVPLNGQDLRRGPCWHE
ALRLVLSASRPPLPGRCRLTLCPRDSSGALH*V
IGVPLSLQTL*APEAAKVSGASQAPTPKEATAC
RPPGPVPIG*PARPRGWNPAPSGTLQTSATASDS
VLALPLTSPEVPLPPSRT*GFKRRACPLESPTM
TEGARDWRCLKTPGTATRCQATLCGPAGVVAAG
AWGGAGGWTGLRKVRTACLCSVAINVTSWERSP

Frame 2

WELWAQPQWQLCVLHP*RCHLWAAPVPDR*DPA
SAGLHPGSTLGDNRCEWD*AELQLGAPGPGQ*C
GPAPPDSAWHSLWPWPGVYRPSMPACGSPGGTG
MSKQMPWTWGL*QQQALLL*GGLGTP*LHHSAQS
NQLPDHRAAPQPPGLIGPGDAWCQLLVPCPPAP
ATLPAQGTHLPVQGSPIWSL*TARTSAEGPAGT
RH*G*CSQLPGPPFQAAAA*PCVQETPVVLFIR*
SGCPSAFRHSEPQKQQRSQGPAKPPPPRKPLPA
DPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPT
VSSLYL*PLRRFRCLQAGLRASRGGRALWSPLP*
LKAPETGGVLRLRAPPRAVKQHSADLPA*LQRG
LGEGLGVGRD*GRSAQPVSAQLQ*T*HLGSVPQ

Sequence ADAM15.iAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC
TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG
TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG
CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT
TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC
CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC
CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA
ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA
GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG
GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG
TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT
GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG
AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT
GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA
CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC
CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG
GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT
GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC
CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT
GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT
GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG
GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA
GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG
CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG
GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC
AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG
CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG
CTGGCACGAGGCACTAAGGCTGAGCTGGCTGACCGACCCAATCCCCCTACCCGCCCTCTGCCCGCTGACCCGGTGGTGAGAAGCCCGAAGGTAACGGTGG
GGGGAGAGAAGGGCACGGCCTCTCCCCCCACCTAGGGCTGTGGTGCTGGTAGCCATGACGGTGGTGGCCGTGGCGAGATGCCCCCTCAGTGCATGAGGGC
ACATATCCCGGTGGTGCCTTTAATGGTGACAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCC
ATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGA
CCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTG
GCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGT
TGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA
  • ADAM15.F1 (forward primer)
  • ADAM15.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK
LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG
SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG
PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL
FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS
WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL
PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ
NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL
EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES
VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV
ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL
NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH
WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN
SICSPDFSGGVNMDHSTSILGVASSIAHELGHS
LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP
GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC
QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD
CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM
HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR
GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG
RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG
SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG
AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT
QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL
LARGTKAELADRPNPPTRPLPADPVVRSPKVTV
GGEKGTASPPT*GCGAGSHDGGGRGEMPPQCMRA
HIPVVPLMVTVSGASQAPTPKEATACRPPGPVP
IG*PARPRGWNPAPSGTLQTSATASDSVLALPL
TSPEVPLPPSRT*GFKRRACPLESPTMTEGARDW
RCLKTPGTATRCQATLCGPAGVVAAGAWGGAGG
WTGLRKVRTACLCSVAINVTSWERSP

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS
Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA
VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG
RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC
SALAALARPGAPLPCGWRCSGPWGSWARAALCL
PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS
QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR
IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT
REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW
SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL
YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L
WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP*
MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST
GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR
TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA
WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ
A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL
WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA
S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI
VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA
CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG
EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV
GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW
AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG
HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL
SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP
ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC
WHEALRLSWLTDPIPLPALCPLTRW*EARR*RW
GERRARPLPPPRAVVLVAMTVVAVARCPLSA*G
HISRWCL*W*QSQGPAKPPPPRKPLPADPQGRCP
SGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL*
PLRRFRCLQAGLRASRGGRALWSPLP*LKAPET
GGVLRLRAPPRAVKQHSADLPA*LQRGLGEGLGV
GRD*GRSAQPVSAQLQ*T*HLGSVPQ

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA
TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR
*R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG
AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV
PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF
LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS
PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE
*GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP
GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP
GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC
THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC
G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP
ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL
AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE
LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ
PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR
PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY
GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL
PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL
*LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH
ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS
GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR*
DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG
Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG
GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS
AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP
PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP
AGTRH*G*AG*PTQSPYPPSAR*PGGEKPEGNGG
GREGHGLSPHLGLWCW*P*RWWPWRDAPSVHEG
TYPGGAFNGDSLRGQPSPHPQGSHCLPTPRAGA
HRVTCPAQGLESRP*WYPPDQRHRLRQCPRSTSD
LSGGSAASKPDLGLQEAGVPSGVPYHD*RRQRL
AVS*DSGHRHALSSNTLRTCRRSCSGGLGRGWG
LDGIEEGPHSLSLLSCNKRDILGAFPR

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