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Sequences

Sequence ADAM15.nAug05

TTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTAGGACCCAGC CTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGGCAGTGATGT GGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGGGCACAGGAA TGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTCAGCTCAAAG CAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCGCCTGCACCA GCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTGCTGGCACGA GGCACTAAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGTCTCAGGGGCCAGCCAAGC CCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACC CTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGC GGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTG CGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATA AACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Mutually exclusive exon skipping

Frame 0

FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQ PLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDV AQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQE CRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLK ATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ RLCQLKGPTCQYRAAQSGPSERPGPPQRALLAR GTKASALSFPAPPSRPLPPDPVSKRLQSQGPAK PPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVP SRPAPPPPTVSSLYL*PLRRFRCLQAGLRASRG GRALWSPLP*LKAPETGGVLRLRAPPRAVKQHS ADLPA*LQRGLGEGLGVGRD*GRSAQPVSAQLQ* T*HLGSVPQ

Frame 1

LGAVGATPVAVMCPAPLEMPFVGSSSARQVGPS LCWAPSGIYSGRQ*M*MGLS*TAAGCTWTWAVM WPSPS*LCLAQPVALAWCV*TIDASVWISWGHRN VEANAMDMGSVTATGTATVRRAGHPLTAPLSSK QPAP*PQGCSSASWSYWSW*CLVPATGTVPACT SDSASSRDPPASTGQPNLVPLNGQDLRRGPCWHE ALRLVLSASRPPLPGRCRLTLCPRDSSLRGQPS PHPQGSHCLPTPRAGAHRVTCPAQGLESRP*WY PPDQRHRLRQCPRSTSDLSGGSAASKPDLGLQEA GVPSGVPYHD*RRQRLAVS*DSGHRHALSSNTL RTCRRSCSGGLGRGWGLDGIEEGPHSLSLLSCN KRDILGAFPR

Frame 2

WELWAQPQWQLCVLHP*RCHLWAAPVPDR*DPA SAGLHPGSTLGDNRCEWD*AELQLGAPGPGQ*C GPAPPDSAWHSLWPWPGVYRPSMPACGSPGGTG MSKQMPWTWGL*QQQALLL*GGLGTP*LHHSAQS NQLPDHRAAPQPPGLIGPGDAWCQLLVPCPPAP ATLPAQGTHLPVQGSPIWSL*TARTSAEGPAGT RH*G*CSQLPGPPFQAAAA*PCVQETPVSGASQA PTPKEATACRPPGPVPIG*PARPRGWNPAPSGT LQTSATASDSVLALPLTSPEVPLPPSRT*GFKR RACPLESPTMTEGARDWRCLKTPGTATRCQATLC GPAGVVAAGAWGGAGGWTGLRKVRTACLCSVAI NVTSWERSP

Sequence ADAM15.dAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG CTGGCACGAGGCACTAAGGCTGAGCTGGCTGACCGACCCAATCCCCCTACCCGCCCTCTGCCCGCTGACCCGGTGGTGAGAAGCCCGAAGTCTCAGGGGC CAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCT AGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCT TCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGC AACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCA GTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Mutually exclusive exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL LARGTKAELADRPNPPTRPLPADPVVRSPKSQG PAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPL VVPSRPAPPPPTVSSLYL*PLRRFRCLQAGLRA SRGGRALWSPLP*LKAPETGGVLRLRAPPRAVK QHSADLPA*LQRGLGEGLGVGRD*GRSAQPVSAQ LQ*T*HLGSVPQ

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC WHEALRLSWLTDPIPLPALCPLTRW*EARSLRG QPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP *WYPPDQRHRLRQCPRSTSDLSGGSAASKPDLGL QEAGVPSGVPYHD*RRQRLAVS*DSGHRHALSS NTLRTCRRSCSGGLGRGWGLDGIEEGPHSLSLL SCNKRDILGAFPR

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP AGTRH*G*AG*PTQSPYPPSAR*PGGEKPEVSGA SQAPTPKEATACRPPGPVPIG*PARPRGWNPAP SGTLQTSATASDSVLALPLTSPEVPLPPSRT*G FKRRACPLESPTMTEGARDWRCLKTPGTATRCQA TLCGPAGVVAAGAWGGAGGWTGLRKVRTACLCS VAINVTSWERSP