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Sequences

Sequence ADAM15.kAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC
TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG
TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG
CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT
TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC
CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC
CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA
ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA
GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG
GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG
TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT
GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG
AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT
GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA
CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC
CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG
GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT
GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC
CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT
GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT
GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG
GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA
GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG
CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG
GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC
AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG
CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACC
CCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTC
CTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTG
AAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTG
GGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA
  • ADAM15.F12 (forward primer)
  • ADAM15.R1 (reverse primer)
  • Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK
LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG
SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG
PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL
FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS
WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL
PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ
NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL
EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES
VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV
ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL
NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH
WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN
SICSPDFSGGVNMDHSTSILGVASSIAHELGHS
LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP
GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC
QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD
CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM
HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR
GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG
RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG
SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG
AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT
QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
LHQRLCQLKGPTCQYSLRGQPSPHPQGSHCLPT
PRAGAHRVTCPAQGLESRP*WYPPDQRHRLRQC
PRSTSDLSGGSAASKPDLGLQEAGVPSGVPYHD*
RRQRLAVS*DSGHRHALSSNTLRTCRRSCSGGL
GRGWGLDGIEEGPHSLSLLSCNKRDILGAFPR

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS
Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA
VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG
RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC
SALAALARPGAPLPCGWRCSGPWGSWARAALCL
PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS
QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR
IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT
REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW
SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL
YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L
WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP*
MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST
GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR
TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA
WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ
A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL
WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA
S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI
VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA
CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG
EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV
GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW
AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG
HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL
SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP
ACTSDSASSRDPPASTVSGASQAPTPKEATACRP
PGPVPIG*PARPRGWNPAPSGTLQTSATASDSV
LALPLTSPEVPLPPSRT*GFKRRACPLESPTMT
EGARDWRCLKTPGTATRCQATLCGPAGVVAAGAW
GGAGGWTGLRKVRTACLCSVAINVTSWERSP

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA
TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR
*R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG
AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV
PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF
LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS
PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE
*GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP
GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP
GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC
THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC
G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP
ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL
AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE
LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ
PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR
PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY
GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL
PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL
*LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH
ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS
GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR*
DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG
Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG
GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS
AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP
PAPATLPAQGTHLPVQSQGPAKPPPPRKPLPAD
PQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVS
SLYL*PLRRFRCLQAGLRASRGGRALWSPLP*L
KAPETGGVLRLRAPPRAVKQHSADLPA*LQRGL
GEGLGVGRD*GRSAQPVSAQLQ*T*HLGSVPQ

Sequence ADAM15.hAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC
TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG
TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG
CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT
TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC
CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC
CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA
ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA
GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG
GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG
TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT
GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG
AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT
GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA
CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC
CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG
GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT
GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC
CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT
GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT
GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG
GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA
GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG
CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG
GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC
AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG
CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG
CTGGCACGAGGCACTAAG
TCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGC
CCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTT
CCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGA
CTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAG
GAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA
  • ADAM15.F12 (forward primer)
  • ADAM15.R1 (reverse primer)
  • Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK
LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG
SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG
PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL
FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS
WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL
PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ
NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL
EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES
VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV
ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL
NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH
WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN
SICSPDFSGGVNMDHSTSILGVASSIAHELGHS
LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP
GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC
QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD
CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM
HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR
GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG
RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG
SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG
AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT
QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL
LARGTK
SQGPAKPPPPRKPLPADPQGRCPSGDL
PGPGAGIPPLVVPSRPAPPPPTVSSLYL*PLRRF
RCLQAGLRASRGGRALWSPLP*LKAPETGGVLR
LRAPPRAVKQHSADLPA*LQRGLGEGLGVGRD*
GRSAQPVSAQLQ*T*HLGSVPQ

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS
Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA
VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG
RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC
SALAALARPGAPLPCGWRCSGPWGSWARAALCL
PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS
QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR
IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT
REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW
SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL
YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L
WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP*
MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST
GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR
TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA
WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ
A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL
WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA
S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI
VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA
CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG
EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV
GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW
AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG
HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL
SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP
ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC
WHEALS
LRGQPSPHPQGSHCLPTPRAGAHRVTC
PAQGLESRP*WYPPDQRHRLRQCPRSTSDLSGG
SAASKPDLGLQEAGVPSGVPYHD*RRQRLAVS*D
SGHRHALSSNTLRTCRRSCSGGLGRGWGLDGIE
EGPHSLSLLSCNKRDILGAFPR

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA
TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR
*R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG
AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV
PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF
LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS
PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE
*GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP
GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP
GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC
THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC
G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP
ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL
AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE
LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ
PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR
PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY
GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL
PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL
*LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH
ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS
GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR*
DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG
Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG
GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS
AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP
PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP
AGTRH*
VSGASQAPTPKEATACRPPGPVPIG*PA
RPRGWNPAPSGTLQTSATASDSVLALPLTSPEV
PLPPSRT*GFKRRACPLESPTMTEGARDWRCLK
TPGTATRCQATLCGPAGVVAAGAWGGAGGWTGLR
KVRTACLCSVAINVTSWERSP

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