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Sequences

Sequence APP.eAug05

GGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCT GAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAA CCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGC CCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTC CAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTA AAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACAT GGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTC AATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTC AGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGAT TCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGAT GCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTG GGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCG ACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGT GTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCA CCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGC AGCCTCTGAAGTTGGACAGCAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATT AATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCA AACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTT TACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTT AAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATA TAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATC TTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTC TCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCC GGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGA AGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTC AATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F9 (forward primer)
APP.R1 (reverse primer)
Single exon skipping

Frame 0

GG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRSG *GGRRRSR**RGR*GW**GRGRG*GTLRRSHREN HQHCHHHHHHHRVCGRGGSSVPKFTQDYPGTSC PRSC*TSYNSSQYP*CR*QVSRDTWG*E*TCPF PESQREA*GQAPRENVPGHERMGRGRTSSKELA* S**EGSYPAFPGESGIFGTGSSQRETAAGGDTH GQSGSHAQ*PPPPGPGELHHRSAGCSSSASSRV QYAKEVCPRRTEGQTAHPKAFRACAHGGSQESRS DPVPGYDTPPCDL*AHESVSLPALQRACSGRGD SG*S**AASERAKLFR*RLGQHD**TKDQLRKR CSHAIFDRNENHRGAPSREWRVQPGRSPAVAFFW G*LCASQHRKRRFWVDKYQDGGDL*SEDGCRIP T*LRI*SSSSKIGVLCRRCGFKQRCNHWTHGGR CCHSDSDRHHLGDAEEETVHIHSSWCGGG*RRCH PRGAPPVQDAAERLRKSNLQVL*ADAELDPRHS SL*SWTATNPFYDLLIIAF*QLCCNTSRCLNLN *STHQ*CILSLFTFWSLYYIINGFCVL*RI*LYQ TSA*IDSLLIIYHIAP*PVVYYSCGL*PN*VLL YICFKNRWGMLHVNVGVQLLLLPKYSFPDHYAF *S*TFLSISDALERFFFHDCILLYRLLLLLYL*Y RN*EDTHVCFFVPVLCAHIRH*DFKLFFFCPRI FGSLIKKRIPVHCKHFYGAGGEGCSAGLQLPRI LQNNFLQDDCTESLLMT*SLSTLYYINKLNKITP GKTFL*RMTTDIK*SK*FWVGRRGRFNFL*PV* SFIYDTKEDENGSGNIRG*GRHAWTNPSFKMCL QFV*NGVFM*INTFLEEHH

Frame 1

EDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA EVEEEEADDDEDDEDGDEVEEEAEEPYEEATER TTSIATTTTTTTESVEEVVRVSQSLLKTTQEPLA RDPVKLPTTAASTPDAVDKYLETPGDENEHAHF QKAKERLEAKHRERMSQVMREWEEAERQAKNLP KADKKAVIQHFQEKVESLEQEAANERQQLVETHM ARVEAMLNDRRRLALENYITALQAVPPRPRHVF NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEI QDEVDELLQKEQNYSDDVLANMISEPRISYGND ALMPSLTETKTTVELLPVNGEFSLDDLQPWHSF GADSVPANTENEGSGLTNIKTEEISEVKMDAEFR HDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGG VVIATVIVITLVMLKKKQYTSIHHGVVEVDAAV TPEERHLSKMQQNGYENPTYKFFEQMQN*TPATA ASEVGQQQTRFMIYSLSPFDSCAVTQVDA*T*I NPHISNVFYLSLHFGLYTTLLMGFVYCKEFSCI KLVHE*ILS*LFIT*PLSQLYIILVVCDPIKSYF TYALRIDGGCFM*TWEFSCFSCLSIPFLITMHF KVKHF*VFQML*RDFFSMTAFYCTDCCFCYICD IGIKRIHTFVSSCLFYVHTLGIETSSFSFFVHVS LGL**RKESLFIVSTFTGRVGRGALLVFNYQEF SKTIFCRMIVQNHCL*HDRFLHCIT*IN*IK*P RARLFFEG*LQTLNNRSNFGWGEEADSIFFNQSE VSFMIQKKMKMEVAI*GDEEGMPGQTLLLRCVF NLYKMVFSCK*IHSWRST

Frame 2

RMTRMSGGAEQTQTMQMGVKTK**K*QRRKKWL RWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQRE PPALPPPPPPPQSLWKRWFECPKVYSRLPRNLL PEILLNFLQQQPVPLMPLTSISRHLGMRMNMPIS RKPKRGLRPSTERECPRS*ENGKRQNVKQRTCL KLIRRQLSSISRRKWNLWNRKQPTRDSSWWRHT WPEWKPCSMTAAAWPWRTTSPLCRLFLLGLVTCS IC*RSMSAQNRRTDSTP*SISSMCAWWIPRKPL RSGPRL*HTSV*FMSA*ISLSPCSTTCLQWPRR FRMKLMSCFRKSKTIQMTSWPT*LVNQGSVTETM LSCHL*PKRKPPWSSFP*MESSAWTISSRGILL GLTLCQPTQKTKVLG*QISRRRRSLK*RWMQNS DMTQDMKFIIKNWCSLQKMWVQTKVQSLDSWWAV LS*RQ*SSSPW*C*RRNSTHPFIMVWWRLTPLS PQRSATCPRCSRTATKIQPTSSLSRCRTRPPPQ QPLKLDSNKPVL*FTHYRLLTAVL*HK*MPELEL IHTSVMYSISLYILVSILHY*WVLCTVKNLAVS N*CMNRFSPDYLSHSPLASCILFLWFVTQLSPT LHML*ESMGDASCERGSSAASLA*VFLS*SLCIL KLNIFKYFRCFREIFFP*LHFTVQIAASAIFVI *ELRGYTRLFLRACFMCTH*ALRLQAFLFLSTY LWVFDKEKNPCSL*ALLRGGWGGVLCWSSITKNS PKQFSAG*LYRIIAYDMIAFYTVLHK*IK*NNP GQDFSLKDDYRH*IIEVILGGEKRQIQFSLTSL KFHL*YKRR*KWKWQYKGMRKACLDKPFF*DVSS ICIKWCFHVNKYILGGAP

Sequence APP.aAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAG AAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAAC AGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCC AAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGC ATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGA CCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCA GAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCA GAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACG AAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAG AAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTC TGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGT GCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATG GTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCA GATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAG AAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATG TATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGAT TCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATC GATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAG TATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACA CACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGA AAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCA GGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGA AGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAA AAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGT TTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F9 (forward primer)
APP.R1 (reverse primer)
Single exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ REPPALPPPPPPPQSLWKRWFERCALNKPRRGRA EQ*SPAGTLM*LKGSVPHSFTADVAATGTTLTQ KSTAWPCVAAPCPKVYSRLPRNLLPEILLNFLQ QQPVPLMPLTSISRHLGMRMNMPISRKPKRGLRP STERECPRS*ENGKRQNVKQRTCLKLIRRQLSS ISRRKWNLWNRKQPTRDSSWWRHTWPEWKPCSM TAAAWPWRTTSPLCRLFLLGLVTCSIC*RSMSAQ NRRTDSTP*SISSMCAWWIPRKPLRSGPRL*HT SV*FMSA*ISLSPCSTTCLQWPRRFRMKLMSCF RKSKTIQMTSWPT*LVNQGSVTETMLSCHL*PKR KPPWSSFP*MESSAWTISSRGILLGLTLCQPTQ KTKLSLLMPALLPTED*PLDQVLG*QISRRRRS LK*RWMQNSDMTQDMKFIIKNWCSLQKMWVQTKV QSLDSWWAVLS*RQ*SSSPW*C*RRNSTHPFIM VWWRLTPLSPQRSATCPRCSRTATKIQPTSSLS RCRTRPPPQQPLKLDSKTIASLPIGVHL*NNVGR NKPVL*FTHYRLLTAVL*HK*MPELELIHTSVM YSISLYILVSILHY*WVLCTVKNLAVSN*CMNR FSPDYLSHSPLASCILFLWFVTQLSPTLHML*ES MGDASCERGSSAASLA*VFLS*SLCILKLNIFK YFRCFREIFFP*LHFTVQIAASAIFVI*ELRGY TRLFLRACFMCTH*ALRLQAFLFLSTYLWVFDKE KNPCSL*ALLRGGWGGVLCWSSITKNSPKQFSA G*LYRIIAYDMIAFYTVLHK*IK*NNPGQDFSL KDDYRH*IIEVILGGEKRQIQFSLTSLKFHL*YK RR*KWKWQYKGMRKACLDKPFF*DVSSICIKWC FHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA* LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC* CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR ENHQHCHHHHHHHRVCGRGGSRGVL*TSRDGAV PSNDLPLVL*CD*REVCPILLRRMWRQPEQL*HR RVLHGRVWQRHVPKFTQDYPGTSCPRSC*TSYN SSQYP*CR*QVSRDTWG*E*TCPFPESQREA*G QAPRENVPGHERMGRGRTSSKELA*S**EGSYPA FPGESGIFGTGSSQRETAAGGDTHGQSGSHAQ* PPPPGPGELHHRSAGCSSSASSRVQYAKEVCPR RTEGQTAHPKAFRACAHGGSQESRSDPVPGYDTP PCDL*AHESVSLPALQRACSGRGDSG*S**AAS ERAKLFR*RLGQHD**TKDQLRKRCSHAIFDRN ENHRGAPSREWRVQPGRSPAVAFFWG*LCASQHR KRS*AC*CPPCCRPRTDHSTRFWVDKYQDGGDL *SEDGCRIPT*LRI*SSSSKIGVLCRRCGFKQR CNHWTHGGRCCHSDSDRHHLGDAEEETVHIHSSW CGGG*RRCHPRGAPPVQDAAERLRKSNLQVL*A DAELDPRHSSL*SWTAKPLLHYPSVSIYRIMWE ETNPFYDLLIIAF*QLCCNTSRCLNLN*STHQ*C ILSLFTFWSLYYIINGFCVL*RI*LYQTSA*ID SLLIIYHIAP*PVVYYSCGL*PN*VLLYICFKN RWGMLHVNVGVQLLLLPKYSFPDHYAF*S*TFLS ISDALERFFFHDCILLYRLLLLLYL*YRN*EDT HVCFFVPVLCAHIRH*DFKLFFFCPRIFGSLIK KRIPVHCKHFYGAGGEGCSAGLQLPRILQNNFLQ DDCTESLLMT*SLSTLYYINKLNKITPGKTFL* RMTTDIK*SK*FWVGRRGRFNFL*PV*SFIYDT KEDENGSGNIRG*GRHAWTNPSFKMCLQFV*NGV FM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE RTTSIATTTTTTTESVEEVVREVCSEQAETGPC RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT EEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTT AASTPDAVDKYLETPGDENEHAHFQKAKERLEA KHRERMSQVMREWEEAERQAKNLPKADKKAVIQ HFQEKVESLEQEAANERQQLVETHMARVEAMLND RRRLALENYITALQAVPPRPRHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTH LRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQ KEQNYSDDVLANMISEPRISYGNDALMPSLTET KTTVELLPVNGEFSLDDLQPWHSFGADSVPANT ENEVEPVDARPAADRGLTTRPGSGLTNIKTEEIS EVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKG AIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH GVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ MQN*TPATAASEVGQQNHCFTTHRCPFIE*CGK KQTRFMIYSLSPFDSCAVTQVDA*T*INPHISN VFYLSLHFGLYTTLLMGFVYCKEFSCIKLVHE*I LS*LFIT*PLSQLYIILVVCDPIKSYFTYALRI DGGCFM*TWEFSCFSCLSIPFLITMHFKVKHF* VFQML*RDFFSMTAFYCTDCCFCYICDIGIKRIH TFVSSCLFYVHTLGIETSSFSFFVHVSLGL**R KESLFIVSTFTGRVGRGALLVFNYQEFSKTIFC RMIVQNHCL*HDRFLHCIT*IN*IK*PRARLFFE G*LQTLNNRSNFGWGEEADSIFFNQSEVSFMIQ KKMKMEVAI*GDEEGMPGQTLLLRCVFNLYKMV FSCK*IHSWRST