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Sequences

Sequence APP.dAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACC AACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGT AAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAG ACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGG CTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGA CAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAA GAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTC CTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCT TGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTT ATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGC TCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGT CCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATG ACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGC TGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGAC CGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCC AACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGG AGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAA CAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATT CATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCT TTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATG TGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATC AGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATG AATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTT AAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACAT TTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGA GGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTG ATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATT TTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTT TCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTAT GATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAA ATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F7 (forward primer)
APP.R2 (reverse primer)
Multiple exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRSTLNCRSPMW*KPT NQ*PSRTGASGAASSARPIPTL*FPTAA*LVSL *VMPFSFLTSANSYTRRGWMFAKLIFTGTPSPKR HAVRRVPTCMTTACCCPAELTSSEG*SLCVAHW LKKVTMWILLMRRRMTRMSGGAEQTQTMQMGVK TK**K*QRRKKWLRWKKKKPMMTRTMRMVMR*RK RLRNPTKKPQREPPALPPPPPPPQSLWKRWFEF LQQQPVPLMPLTSISRHLGMRMNMPISRKPKRG LRPSTERECPRS*ENGKRQNVKQRTCLKLIRRQL SSISRRKWNLWNRKQPTRDSSWWRHTWPEWKPC SMTAAAWPWRTTSPLCRLFLLGLVTCSIC*RSM SAQNRRTDSTP*SISSMCAWWIPRKPLRSGPRL* HTSV*FMSA*ISLSPCSTTCLQWPRRFRMKLMS CFRKSKTIQMTSWPT*LVNQGSVTETMLSCHL* PKRKPPWSSFP*MESSAWTISSRGILLGLTLCQP TQKTKLSLLMPALLPTED*PLDQVLG*QISRRR RSLK*RWMQNSDMTQDMKFIIKNWCSLQKMWVQ TKVQSLDSWWAVLS*RQ*SSSPW*C*RRNSTHPF IMVWWRLTPLSPQRSATCPRCSRTATKIQPTSS LSRCRTRPPPQQPLKLDSKTIASLPIGVHL*NN VGRNKPVL*FTHYRLLTAVL*HK*MPELELIHTS VMYSISLYILVSILHY*WVLCTVKNLAVSN*CM NRFSPDYLSHSPLASCILFLWFVTQLSPTLHML *ESMGDASCERGSSAASLA*VFLS*SLCILKLNI FKYFRCFREIFFP*LHFTVQIAASAIFVI*ELR GYTRLFLRACFMCTH*ALRLQAFLFLSTYLWVF DKEKNPCSL*ALLRGGWGGVLCWSSITKNSPKQF SAG*LYRIIAYDMIAFYTVLHK*IK*NNPGQDF SLKDDYRH*IIEVILGGEKRQIQFSLTSLKFHL *YKRR*KWKWQYKGMRKACLDKPFF*DVSSICIK WCFHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGLP*TADHQCGRSQP TSDHPELVQAGPQAVQDPSPLCDSLPLLSW*VC K*CPSRS*QVQILTPGEDGCLRNSSSLAHRRQR DMQ*EEYQLA*LRHVAALRN*QVPRGRVCVLPTG *RK*QCGFC*CGGG*LGCLVGRSRHRLCRWE*R QSSRSSRGGRSG*GGRRRSR**RGR*GW**GRG RG*GTLRRSHRENHQHCHHHHHHHRVCGRGGSSS YNSSQYP*CR*QVSRDTWG*E*TCPFPESQREA *GQAPRENVPGHERMGRGRTSSKELA*S**EGS YPAFPGESGIFGTGSSQRETAAGGDTHGQSGSHA Q*PPPPGPGELHHRSAGCSSSASSRVQYAKEVC PRRTEGQTAHPKAFRACAHGGSQESRSDPVPGY DTPPCDL*AHESVSLPALQRACSGRGDSG*S**A ASERAKLFR*RLGQHD**TKDQLRKRCSHAIFD RNENHRGAPSREWRVQPGRSPAVAFFWG*LCAS QHRKRS*AC*CPPCCRPRTDHSTRFWVDKYQDGG DL*SEDGCRIPT*LRI*SSSSKIGVLCRRCGFK QRCNHWTHGGRCCHSDSDRHHLGDAEEETVHIH SSWCGGG*RRCHPRGAPPVQDAAERLRKSNLQVL *ADAELDPRHSSL*SWTAKPLLHYPSVSIYRIM WEETNPFYDLLIIAF*QLCCNTSRCLNLN*STH Q*CILSLFTFWSLYYIINGFCVL*RI*LYQTSA* IDSLLIIYHIAP*PVVYYSCGL*PN*VLLYICF KNRWGMLHVNVGVQLLLLPKYSFPDHYAF*S*T FLSISDALERFFFHDCILLYRLLLLLYL*YRN*E DTHVCFFVPVLCAHIRH*DFKLFFFCPRIFGSL IKKRIPVHCKHFYGAGGEGCSAGLQLPRILQNN FLQDDCTESLLMT*SLSTLYYINKLNKITPGKTF L*RMTTDIK*SK*FWVGRRGRFNFL*PV*SFIY DTKEDENGSGNIRG*GRHAWTNPSFKMCLQFV* NGVFM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVYPELQITNVVEAN QPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFV SDALLVPDKCKFLHQERMDVCETHLHWHTVAKE TCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPL AEESDNVDSADAEEDDSDVWWGGADTDYADGSED KVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEE EAEEPYEEATERTTSIATTTTTTTESVEEVVRV PTTAASTPDAVDKYLETPGDENEHAHFQKAKERL EAKHRERMSQVMREWEEAERQAKNLPKADKKAV IQHFQEKVESLEQEAANERQQLVETHMARVEAM LNDRRRLALENYITALQAVPPRPRHVFNMLKKYV RAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM THLRVIYERMNQSLSLLYNVPAVAEEIQDEVDE LLQKEQNYSDDVLANMISEPRISYGNDALMPSLT ETKTTVELLPVNGEFSLDDLQPWHSFGADSVPA NTENEVEPVDARPAADRGLTTRPGSGLTNIKTE EISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSN KGAIIGLMVGGVVIATVIVITLVMLKKKQYTSI HHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF FEQMQN*TPATAASEVGQQNHCFTTHRCPFIE*C GKKQTRFMIYSLSPFDSCAVTQVDA*T*INPHI SNVFYLSLHFGLYTTLLMGFVYCKEFSCIKLVH E*ILS*LFIT*PLSQLYIILVVCDPIKSYFTYAL RIDGGCFM*TWEFSCFSCLSIPFLITMHFKVKH F*VFQML*RDFFSMTAFYCTDCCFCYICDIGIK RIHTFVSSCLFYVHTLGIETSSFSFFVHVSLGL* *RKESLFIVSTFTGRVGRGALLVFNYQEFSKTI FCRMIVQNHCL*HDRFLHCIT*IN*IK*PRARL FFEG*LQTLNNRSNFGWGEEADSIFFNQSEVSFM IQKKMKMEVAI*GDEEGMPGQTLLLRCVFNLYK MVFSCK*IHSWRST

Sequence APP.cAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTT GACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGG TCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTT GGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAAC TACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCC TAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAA TCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGAC GTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCG TGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGC CCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTC CGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCG GTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGT CACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACA GCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACT CATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGG TCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAG CCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGT GGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTT TTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTT TATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCA CTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTT ATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAAT CGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAA TATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTG GAGGAGCACCAT

APP.F7 (forward primer)
APP.R2 (reverse primer)
Multiple exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ REPPALPPPPPPPQSLWKRWFEFLQQQPVPLMPL TSISRHLGMRMNMPISRKPKRGLRPSTERECPR S*ENGKRQNVKQRTCLKLIRRQLSSISRRKWNL WNRKQPTRDSSWWRHTWPEWKPCSMTAAAWPWRT TSPLCRLFLLGLVTCSIC*RSMSAQNRRTDSTP *SISSMCAWWIPRKPLRSGPRL*HTSV*FMSA* ISLSPCSTTCLQWPRRFRMKLMSCFRKSKTIQMT SWPT*LVNQGSVTETMLSCHL*PKRKPPWSSFP *MESSAWTISSRGILLGLTLCQPTQKTKLSLLM PALLPTED*PLDQVLG*QISRRRRSLK*RWMQNS DMTQDMKFIIKNWCSLQKMWVQTKVQSLDSWWA VLS*RQ*SSSPW*C*RRNSTHPFIMVWWRLTPL SPQRSATCPRCSRTATKIQPTSSLSRCRTRPPPQ QPLKLDSKTIASLPIGVHL*NNVGRNKPVL*FT HYRLLTAVL*HK*MPELELIHTSVMYSISLYIL VSILHY*WVLCTVKNLAVSN*CMNRFSPDYLSHS PLASCILFLWFVTQLSPTLHML*ESMGDASCER GSSAASLA*VFLS*SLCILKLNIFKYFRCFREI FFP*LHFTVQIAASAIFVI*ELRGYTRLFLRACF MCTH*ALRLQAFLFLSTYLWVFDKEKNPCSL*A LLRGGWGGVLCWSSITKNSPKQFSAG*LYRIIA YDMIAFYTVLHK*IK*NNPGQDFSLKDDYRH*II EVILGGEKRQIQFSLTSLKFHL*YKRR*KWKWQ YKGMRKACLDKPFF*DVSSICIKWCFHVNKYIL GGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA* LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC* CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR ENHQHCHHHHHHHRVCGRGGSSSYNSSQYP*CR *QVSRDTWG*E*TCPFPESQREA*GQAPRENVPG HERMGRGRTSSKELA*S**EGSYPAFPGESGIF GTGSSQRETAAGGDTHGQSGSHAQ*PPPPGPGE LHHRSAGCSSSASSRVQYAKEVCPRRTEGQTAHP KAFRACAHGGSQESRSDPVPGYDTPPCDL*AHE SVSLPALQRACSGRGDSG*S**AASERAKLFR* RLGQHD**TKDQLRKRCSHAIFDRNENHRGAPSR EWRVQPGRSPAVAFFWG*LCASQHRKRS*AC*C PPCCRPRTDHSTRFWVDKYQDGGDL*SEDGCRI PT*LRI*SSSSKIGVLCRRCGFKQRCNHWTHGGR CCHSDSDRHHLGDAEEETVHIHSSWCGGG*RRC HPRGAPPVQDAAERLRKSNLQVL*ADAELDPRH SSL*SWTAKPLLHYPSVSIYRIMWEETNPFYDLL IIAF*QLCCNTSRCLNLN*STHQ*CILSLFTFW SLYYIINGFCVL*RI*LYQTSA*IDSLLIIYHI AP*PVVYYSCGL*PN*VLLYICFKNRWGMLHVNV GVQLLLLPKYSFPDHYAF*S*TFLSISDALERF FFHDCILLYRLLLLLYL*YRN*EDTHVCFFVPV LCAHIRH*DFKLFFFCPRIFGSLIKKRIPVHCKH FYGAGGEGCSAGLQLPRILQNNFLQDDCTESLL MT*SLSTLYYINKLNKITPGKTFL*RMTTDIK* SK*FWVGRRGRFNFL*PV*SFIYDTKEDENGSGN IRG*GRHAWTNPSFKMCLQFV*NGVFM*INTFL EEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE RTTSIATTTTTTTESVEEVVRVPTTAASTPDAV DKYLETPGDENEHAHFQKAKERLEAKHRERMSQ VMREWEEAERQAKNLPKADKKAVIQHFQEKVESL EQEAANERQQLVETHMARVEAMLNDRRRLALEN YITALQAVPPRPRHVFNMLKKYVRAEQKDRQHT LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMN QSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDD VLANMISEPRISYGNDALMPSLTETKTTVELLP VNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA RPAADRGLTTRPGSGLTNIKTEEISEVKMDAEF RHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVG GVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAV TPEERHLSKMQQNGYENPTYKFFEQMQN*TPAT AASEVGQQNHCFTTHRCPFIE*CGKKQTRFMIY SLSPFDSCAVTQVDA*T*INPHISNVFYLSLHFG LYTTLLMGFVYCKEFSCIKLVHE*ILS*LFIT* PLSQLYIILVVCDPIKSYFTYALRIDGGCFM*T WEFSCFSCLSIPFLITMHFKVKHF*VFQML*RDF FSMTAFYCTDCCFCYICDIGIKRIHTFVSSCLF YVHTLGIETSSFSFFVHVSLGL**RKESLFIVS TFTGRVGRGALLVFNYQEFSKTIFCRMIVQNHCL *HDRFLHCIT*IN*IK*PRARLFFEG*LQTLNN RSNFGWGEEADSIFFNQSEVSFMIQKKMKMEVA I*GDEEGMPGQTLLLRCVFNLYKMVFSCK*IHSW RST

Sequence APP.aAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAG AAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAAC AGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCC AAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGC ATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGA CCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCA GAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCA GAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACG AAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAG AAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTC TGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGT GCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATG GTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCA GATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAG AAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATG TATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGAT TCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATC GATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAG TATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACA CACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGA AAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCA GGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGA AGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAA AAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGT TTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F7 (forward primer)
APP.R2 (reverse primer)
Multiple exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ REPPALPPPPPPPQSLWKRWFERCALNKPRRGRA EQ*SPAGTLM*LKGSVPHSFTADVAATGTTLTQ KSTAWPCVAAPCPKVYSRLPRNLLPEILLNFLQ QQPVPLMPLTSISRHLGMRMNMPISRKPKRGLRP STERECPRS*ENGKRQNVKQRTCLKLIRRQLSS ISRRKWNLWNRKQPTRDSSWWRHTWPEWKPCSM TAAAWPWRTTSPLCRLFLLGLVTCSIC*RSMSAQ NRRTDSTP*SISSMCAWWIPRKPLRSGPRL*HT SV*FMSA*ISLSPCSTTCLQWPRRFRMKLMSCF RKSKTIQMTSWPT*LVNQGSVTETMLSCHL*PKR KPPWSSFP*MESSAWTISSRGILLGLTLCQPTQ KTKLSLLMPALLPTED*PLDQVLG*QISRRRRS LK*RWMQNSDMTQDMKFIIKNWCSLQKMWVQTKV QSLDSWWAVLS*RQ*SSSPW*C*RRNSTHPFIM VWWRLTPLSPQRSATCPRCSRTATKIQPTSSLS RCRTRPPPQQPLKLDSKTIASLPIGVHL*NNVGR NKPVL*FTHYRLLTAVL*HK*MPELELIHTSVM YSISLYILVSILHY*WVLCTVKNLAVSN*CMNR FSPDYLSHSPLASCILFLWFVTQLSPTLHML*ES MGDASCERGSSAASLA*VFLS*SLCILKLNIFK YFRCFREIFFP*LHFTVQIAASAIFVI*ELRGY TRLFLRACFMCTH*ALRLQAFLFLSTYLWVFDKE KNPCSL*ALLRGGWGGVLCWSSITKNSPKQFSA G*LYRIIAYDMIAFYTVLHK*IK*NNPGQDFSL KDDYRH*IIEVILGGEKRQIQFSLTSLKFHL*YK RR*KWKWQYKGMRKACLDKPFF*DVSSICIKWC FHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA* LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC* CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR ENHQHCHHHHHHHRVCGRGGSRGVL*TSRDGAV PSNDLPLVL*CD*REVCPILLRRMWRQPEQL*HR RVLHGRVWQRHVPKFTQDYPGTSCPRSC*TSYN SSQYP*CR*QVSRDTWG*E*TCPFPESQREA*G QAPRENVPGHERMGRGRTSSKELA*S**EGSYPA FPGESGIFGTGSSQRETAAGGDTHGQSGSHAQ* PPPPGPGELHHRSAGCSSSASSRVQYAKEVCPR RTEGQTAHPKAFRACAHGGSQESRSDPVPGYDTP PCDL*AHESVSLPALQRACSGRGDSG*S**AAS ERAKLFR*RLGQHD**TKDQLRKRCSHAIFDRN ENHRGAPSREWRVQPGRSPAVAFFWG*LCASQHR KRS*AC*CPPCCRPRTDHSTRFWVDKYQDGGDL *SEDGCRIPT*LRI*SSSSKIGVLCRRCGFKQR CNHWTHGGRCCHSDSDRHHLGDAEEETVHIHSSW CGGG*RRCHPRGAPPVQDAAERLRKSNLQVL*A DAELDPRHSSL*SWTAKPLLHYPSVSIYRIMWE ETNPFYDLLIIAF*QLCCNTSRCLNLN*STHQ*C ILSLFTFWSLYYIINGFCVL*RI*LYQTSA*ID SLLIIYHIAP*PVVYYSCGL*PN*VLLYICFKN RWGMLHVNVGVQLLLLPKYSFPDHYAF*S*TFLS ISDALERFFFHDCILLYRLLLLLYL*YRN*EDT HVCFFVPVLCAHIRH*DFKLFFFCPRIFGSLIK KRIPVHCKHFYGAGGEGCSAGLQLPRILQNNFLQ DDCTESLLMT*SLSTLYYINKLNKITPGKTFL* RMTTDIK*SK*FWVGRRGRFNFL*PV*SFIYDT KEDENGSGNIRG*GRHAWTNPSFKMCLQFV*NGV FM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE RTTSIATTTTTTTESVEEVVREVCSEQAETGPC RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT EEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTT AASTPDAVDKYLETPGDENEHAHFQKAKERLEA KHRERMSQVMREWEEAERQAKNLPKADKKAVIQ HFQEKVESLEQEAANERQQLVETHMARVEAMLND RRRLALENYITALQAVPPRPRHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTH LRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQ KEQNYSDDVLANMISEPRISYGNDALMPSLTET KTTVELLPVNGEFSLDDLQPWHSFGADSVPANT ENEVEPVDARPAADRGLTTRPGSGLTNIKTEEIS EVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKG AIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH GVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ MQN*TPATAASEVGQQNHCFTTHRCPFIE*CGK KQTRFMIYSLSPFDSCAVTQVDA*T*INPHISN VFYLSLHFGLYTTLLMGFVYCKEFSCIKLVHE*I LS*LFIT*PLSQLYIILVVCDPIKSYFTYALRI DGGCFM*TWEFSCFSCLSIPFLITMHFKVKHF* VFQML*RDFFSMTAFYCTDCCFCYICDIGIKRIH TFVSSCLFYVHTLGIETSSFSFFVHVSLGL**R KESLFIVSTFTGRVGRGALLVFNYQEFSKTIFC RMIVQNHCL*HDRFLHCIT*IN*IK*PRARLFFE G*LQTLNNRSNFGWGEEADSIFFNQSEVSFMIQ KKMKMEVAI*GDEEGMPGQTLLLRCVFNLYKMV FSCK*IHSWRST