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Sequences

Sequence APP.dAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG
GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG
ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACC
AACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGT
AAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAG
ACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGG
CTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGA
CAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAA
GAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTC
CTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCT
TGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTT
ATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGC
TCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGT
CCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATG
ACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGC
TGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGAC
CGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCC
AACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGG
AGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAA
CAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATT
CATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCT
TTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATG
TGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATC
AGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATG
AATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTT
AAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACAT
TTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGA
GGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTG
ATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATT
TTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTT
TCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTAT
GATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAA
ATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT
  • APP.F7 (forward primer)
  • APP.R2 (reverse primer)
  • Single exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR
GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR
CCPVWHCSCWPPGRLGRWRSTLNCRSPMW*KPT
NQ*PSRTGASGAASSARPIPTL*FPTAA*LVSL
*VMPFSFLTSANSYTRRGWMFAKLIFTGTPSPKR
HAVRRVPTCMTTACCCPAELTSSEG*SLCVAHW
LKKVTMWILLMRRRMTRMSGGAEQTQTMQMGVK
TK**K*QRRKKWLRWKKKKPMMTRTMRMVMR*RK
RLRNPTKKPQREPPALPPPPPPPQSLWKRWFEF
LQQQPVPLMPLTSISRHLGMRMNMPISRKPKRG
LRPSTERECPRS*ENGKRQNVKQRTCLKLIRRQL
SSISRRKWNLWNRKQPTRDSSWWRHTWPEWKPC
SMTAAAWPWRTTSPLCRLFLLGLVTCSIC*RSM
SAQNRRTDSTP*SISSMCAWWIPRKPLRSGPRL*
HTSV*FMSA*ISLSPCSTTCLQWPRRFRMKLMS
CFRKSKTIQMTSWPT*LVNQGSVTETMLSCHL*
PKRKPPWSSFP*MESSAWTISSRGILLGLTLCQP
TQKTKLSLLMPALLPTED*PLDQVLG*QISRRR
RSLK*RWMQNSDMTQDMKFIIKNWCSLQKMWVQ
TKVQSLDSWWAVLS*RQ*SSSPW*C*RRNSTHPF
IMVWWRLTPLSPQRSATCPRCSRTATKIQPTSS
LSRCRTRPPPQQPLKLDSKTIASLPIGVHL*NN
VGRNKPVL*FTHYRLLTAVL*HK*MPELELIHTS
VMYSISLYILVSILHY*WVLCTVKNLAVSN*CM
NRFSPDYLSHSPLASCILFLWFVTQLSPTLHML
*ESMGDASCERGSSAASLA*VFLS*SLCILKLNI
FKYFRCFREIFFP*LHFTVQIAASAIFVI*ELR
GYTRLFLRACFMCTH*ALRLQAFLFLSTYLWVF
DKEKNPCSL*ALLRGGWGGVLCWSSITKNSPKQF
SAG*LYRIIAYDMIAFYTVLHK*IK*NNPGQDF
SLKDDYRH*IIEVILGGEKRQIQFSLTSLKFHL
*YKRR*KWKWQYKGMRKACLDKPFF*DVSSICIK
WCFHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA
GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR
DAARFGTAPAGRLDGSGAGGLP*TADHQCGRSQP
TSDHPELVQAGPQAVQDPSPLCDSLPLLSW*VC
K*CPSRS*QVQILTPGEDGCLRNSSSLAHRRQR
DMQ*EEYQLA*LRHVAALRN*QVPRGRVCVLPTG
*RK*QCGFC*CGGG*LGCLVGRSRHRLCRWE*R
QSSRSSRGGRSG*GGRRRSR**RGR*GW**GRG
RG*GTLRRSHRENHQHCHHHHHHHRVCGRGGSSS
YNSSQYP*CR*QVSRDTWG*E*TCPFPESQREA
*GQAPRENVPGHERMGRGRTSSKELA*S**EGS
YPAFPGESGIFGTGSSQRETAAGGDTHGQSGSHA
Q*PPPPGPGELHHRSAGCSSSASSRVQYAKEVC
PRRTEGQTAHPKAFRACAHGGSQESRSDPVPGY
DTPPCDL*AHESVSLPALQRACSGRGDSG*S**A
ASERAKLFR*RLGQHD**TKDQLRKRCSHAIFD
RNENHRGAPSREWRVQPGRSPAVAFFWG*LCAS
QHRKRS*AC*CPPCCRPRTDHSTRFWVDKYQDGG
DL*SEDGCRIPT*LRI*SSSSKIGVLCRRCGFK
QRCNHWTHGGRCCHSDSDRHHLGDAEEETVHIH
SSWCGGG*RRCHPRGAPPVQDAAERLRKSNLQVL
*ADAELDPRHSSL*SWTAKPLLHYPSVSIYRIM
WEETNPFYDLLIIAF*QLCCNTSRCLNLN*STH
Q*CILSLFTFWSLYYIINGFCVL*RI*LYQTSA*
IDSLLIIYHIAP*PVVYYSCGL*PN*VLLYICF
KNRWGMLHVNVGVQLLLLPKYSFPDHYAF*S*T
FLSISDALERFFFHDCILLYRLLLLLYL*YRN*E
DTHVCFFVPVLCAHIRH*DFKLFFFCPRIFGSL
IKKRIPVHCKHFYGAGGEGCSAGLQLPRILQNN
FLQDDCTESLLMT*SLSTLYYINKLNKITPGKTF
L*RMTTDIK*SK*FWVGRRGRFNFL*PV*SFIY
DTKEDENGSGNIRG*GRHAWTNPSFKMCLQFV*
NGVFM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR
GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA
MLPGLALLLLAAWTARALEVYPELQITNVVEAN
QPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFV
SDALLVPDKCKFLHQERMDVCETHLHWHTVAKE
TCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPL
AEESDNVDSADAEEDDSDVWWGGADTDYADGSED
KVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEE
EAEEPYEEATERTTSIATTTTTTTESVEEVVRV
PTTAASTPDAVDKYLETPGDENEHAHFQKAKERL
EAKHRERMSQVMREWEEAERQAKNLPKADKKAV
IQHFQEKVESLEQEAANERQQLVETHMARVEAM
LNDRRRLALENYITALQAVPPRPRHVFNMLKKYV
RAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM
THLRVIYERMNQSLSLLYNVPAVAEEIQDEVDE
LLQKEQNYSDDVLANMISEPRISYGNDALMPSLT
ETKTTVELLPVNGEFSLDDLQPWHSFGADSVPA
NTENEVEPVDARPAADRGLTTRPGSGLTNIKTE
EISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSN
KGAIIGLMVGGVVIATVIVITLVMLKKKQYTSI
HHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
FEQMQN*TPATAASEVGQQNHCFTTHRCPFIE*C
GKKQTRFMIYSLSPFDSCAVTQVDA*T*INPHI
SNVFYLSLHFGLYTTLLMGFVYCKEFSCIKLVH
E*ILS*LFIT*PLSQLYIILVVCDPIKSYFTYAL
RIDGGCFM*TWEFSCFSCLSIPFLITMHFKVKH
F*VFQML*RDFFSMTAFYCTDCCFCYICDIGIK
RIHTFVSSCLFYVHTLGIETSSFSFFVHVSLGL*
*RKESLFIVSTFTGRVGRGALLVFNYQEFSKTI
FCRMIVQNHCL*HDRFLHCIT*IN*IK*PRARL
FFEG*LQTLNNRSNFGWGEEADSIFFNQSEVSFM
IQKKMKMEVAI*GDEEGMPGQTLLLRCVFNLYK
MVFSCK*IHSWRST

Sequence APP.cAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG
GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG
ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA
TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA
AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG
GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA
AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA
CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT
GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG
TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA
GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTT
GACAAGTATCTCG
AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGG
TCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTT
GGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAAC
TACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCC
TAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAA
TCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGAC
GTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCG
TGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGC
CCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTC
CGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCG
GTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGT
CACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACA
GCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACT
CATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGG
TCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAG
CCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGT
GGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTT
TTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTT
TATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCA
CTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTT
ATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAAT
CGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAA
TATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTG
GAGGAGCACCAT
  • APP.F7 (forward primer)
  • APP.R2 (reverse primer)
  • Single exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR
GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR
CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR
LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR
KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG
AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA
NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM
TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM
RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK
WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ
REPPALPPPPPPPQSLWKRWFEFLQQQPVPLMPL
TSIS
RHLGMRMNMPISRKPKRGLRPSTERECPR
S*ENGKRQNVKQRTCLKLIRRQLSSISRRKWNL
WNRKQPTRDSSWWRHTWPEWKPCSMTAAAWPWRT
TSPLCRLFLLGLVTCSIC*RSMSAQNRRTDSTP
*SISSMCAWWIPRKPLRSGPRL*HTSV*FMSA*
ISLSPCSTTCLQWPRRFRMKLMSCFRKSKTIQMT
SWPT*LVNQGSVTETMLSCHL*PKRKPPWSSFP
*MESSAWTISSRGILLGLTLCQPTQKTKLSLLM
PALLPTED*PLDQVLG*QISRRRRSLK*RWMQNS
DMTQDMKFIIKNWCSLQKMWVQTKVQSLDSWWA
VLS*RQ*SSSPW*C*RRNSTHPFIMVWWRLTPL
SPQRSATCPRCSRTATKIQPTSSLSRCRTRPPPQ
QPLKLDSKTIASLPIGVHL*NNVGRNKPVL*FT
HYRLLTAVL*HK*MPELELIHTSVMYSISLYIL
VSILHY*WVLCTVKNLAVSN*CMNRFSPDYLSHS
PLASCILFLWFVTQLSPTLHML*ESMGDASCER
GSSAASLA*VFLS*SLCILKLNIFKYFRCFREI
FFP*LHFTVQIAASAIFVI*ELRGYTRLFLRACF
MCTH*ALRLQAFLFLSTYLWVFDKEKNPCSL*A
LLRGGWGGVLCWSSITKNSPKQFSAG*LYRIIA
YDMIAFYTVLHK*IK*NNPGQDFSLKDDYRH*II
EVILGGEKRQIQFSLTSLKFHL*YKRR*KWKWQ
YKGMRKACLDKPFF*DVSSICIKWCFHVNKYIL
GGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA
GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR
DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD
CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG
RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA
GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ
ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA*
LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC*
CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS
G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR
ENHQHCHHHHHHHRVCGRGGSSSYNSSQYP*CR
*QVSR
DTWG*E*TCPFPESQREA*GQAPRENVPG
HERMGRGRTSSKELA*S**EGSYPAFPGESGIF
GTGSSQRETAAGGDTHGQSGSHAQ*PPPPGPGE
LHHRSAGCSSSASSRVQYAKEVCPRRTEGQTAHP
KAFRACAHGGSQESRSDPVPGYDTPPCDL*AHE
SVSLPALQRACSGRGDSG*S**AASERAKLFR*
RLGQHD**TKDQLRKRCSHAIFDRNENHRGAPSR
EWRVQPGRSPAVAFFWG*LCASQHRKRS*AC*C
PPCCRPRTDHSTRFWVDKYQDGGDL*SEDGCRI
PT*LRI*SSSSKIGVLCRRCGFKQRCNHWTHGGR
CCHSDSDRHHLGDAEEETVHIHSSWCGGG*RRC
HPRGAPPVQDAAERLRKSNLQVL*ADAELDPRH
SSL*SWTAKPLLHYPSVSIYRIMWEETNPFYDLL
IIAF*QLCCNTSRCLNLN*STHQ*CILSLFTFW
SLYYIINGFCVL*RI*LYQTSA*IDSLLIIYHI
AP*PVVYYSCGL*PN*VLLYICFKNRWGMLHVNV
GVQLLLLPKYSFPDHYAF*S*TFLSISDALERF
FFHDCILLYRLLLLLYL*YRN*EDTHVCFFVPV
LCAHIRH*DFKLFFFCPRIFGSLIKKRIPVHCKH
FYGAGGEGCSAGLQLPRILQNNFLQDDCTESLL
MT*SLSTLYYINKLNKITPGKTFL*RMTTDIK*
SK*FWVGRRGRFNFL*PV*SFIYDTKEDENGSGN
IRG*GRHAWTNPSFKMCLQFV*NGVFM*INTFL
EEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR
GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ
IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE
GILQYCQEVYPELQITNVVEANQPVTIQNWCKR
GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC
KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD
YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD
AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE
VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE
RTTSIATTTTTTTESVEEVVRVPTTAASTPDAV
DKYL
ETPGDENEHAHFQKAKERLEAKHRERMSQ
VMREWEEAERQAKNLPKADKKAVIQHFQEKVESL
EQEAANERQQLVETHMARVEAMLNDRRRLALEN
YITALQAVPPRPRHVFNMLKKYVRAEQKDRQHT
LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMN
QSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDD
VLANMISEPRISYGNDALMPSLTETKTTVELLP
VNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA
RPAADRGLTTRPGSGLTNIKTEEISEVKMDAEF
RHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVG
GVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAV
TPEERHLSKMQQNGYENPTYKFFEQMQN*TPAT
AASEVGQQNHCFTTHRCPFIE*CGKKQTRFMIY
SLSPFDSCAVTQVDA*T*INPHISNVFYLSLHFG
LYTTLLMGFVYCKEFSCIKLVHE*ILS*LFIT*
PLSQLYIILVVCDPIKSYFTYALRIDGGCFM*T
WEFSCFSCLSIPFLITMHFKVKHF*VFQML*RDF
FSMTAFYCTDCCFCYICDIGIKRIHTFVSSCLF
YVHTLGIETSSFSFFVHVSLGL**RKESLFIVS
TFTGRVGRGALLVFNYQEFSKTIFCRMIVQNHCL
*HDRFLHCIT*IN*IK*PRARLFFEG*LQTLNN
RSNFGWGEEADSIFFNQSEVSFMIQKKMKMEVA
I*GDEEGMPGQTLLLRCVFNLYKMVFSCK*IHSW
RST

Sequence APP.fAug05

CTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA
TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAAC
TCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTC
CGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAG
CAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGA
GGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACC
ACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTG
AAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCA
TTCC
TACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTT
GAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTA
TCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT
CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTC
CGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGA
CACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGGTGCAGT
GGCTCATGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGTGGGCAGATGACTTGAGCCCAGAAGTTCAAGACCAGAATGGGAAACATGGCAAGACCACAT
TTCTACAAAAAAATTATCCAGGCATGATAACATCTATTTGTAGTCCCAGCTACTCAGGAGGCTGTGGTGGGAGGATCTCCTGAGCCTGGGGTGGCTGAGG
CTGCAGTGAGCCTTGATCACGCCACCTGGGCAATAGAGCAAGACCCTGTCTCAAAAAAAGGAAGAAAAAGACTATTATTTCCCCCATTGAATGGTCTTGG
CACTATTACACAAAATCAATTGTCCATAGATAATATGGGTTTATTTCTTAATTCTTAGTTCTTTTCTTTGATCTGTGTGCCTGTGCTTACTGTAGTACCA
CACTGTTTTGATTATTGTAGCTTTGTAGTAAATTTTGAAATCAGCAAGTGTGAGTCCGTTATCTTTGTTCTTCTTTTTCAATATTACTTTGAGTATCCGG
AGTCTCTTGCATTACAACATGAATTTTAAGATCTTCC
  • APP.F7 (forward primer)
  • APP.R2 (reverse primer)
  • Single exon skipping

Frame 0

LQITNVVEANQPVTIQNWCKRGRKQCKTHPHFV
IPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF
RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGG
ADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDE
DDEDGDEVEEEAEEPYEEATERTTSIATTTTTT
TESVEEVVREVCSEQAETGPCRAMISRWYFDVT
EGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
IP
TTAASTPDAVDKYLETPGDENEHAHFQKAKERL
EAKHRERMSQVMREWEEAERQAKNLPKADKKAV
IQHFQEKVESLEQEAANERQQLVETHMARVEAML
NDRRRLALENYITALQAVPPRPRHVFNMLKKYV
RAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM
THLRVIYERMNQSLSLLYNVPAVAEEIQDEVGAV
AHACNSSILGGQGGQMT*AQKFKTRMGNMARPH
FYKKIIQA**HLFVVPATQEAVVGGSPEPGVAE
AAVSLDHATWAIEQDPVSKKGRKRLLFPPLNGLG
TITQNQLSIDNMGLFLNS*FFSLICVPVLTVVP
HCFDYCSFVVNFEISKCESVIFVLLFQYYFEYP
ESLALQHEF*DL

Frame 1

CRSPMW*KPTNQ*PSRTGASGAASSARPIPTL*
FPTAA*LVSL*VMPFSFLTSANSYTRRGWMFAK
LIFTGTPSPKRHAVRRVPTCMTTACCCPAELTSS
EG*SLCVAHWLKKVTMWILLMRRRMTRMSGGAE
QTQTMQMGVKTK**K*QRRKKWLRWKKKKPMMT
RTMRMVMR*RKRLRNPTKKPQREPPALPPPPPPP
QSLWKRWFERCALNKPRRGRAEQ*SPAGTLM*L
KGSVPHSFTADVAATGTTLTQKSTAWPCVAAP
F
LQQQPVPLMPLTSISRHLGMRMNMPISRKPKRGL
RPSTERECPRS*ENGKRQNVKQRTCLKLIRRQL
SSISRRKWNLWNRKQPTRDSSWWRHTWPEWKPC
SMTAAAWPWRTTSPLCRLFLLGLVTCSIC*RSMS
AQNRRTDSTP*SISSMCAWWIPRKPLRSGPRL*
HTSV*FMSA*ISLSPCSTTCLQWPRRFRMKLVQ
WLMPVIPAFWEAKVGR*LEPRSSRPEWETWQDHI
STKKLSRHDNIYL*SQLLRRLWWEDLLSLGWLR
LQ*ALITPPGQ*SKTLSQKKEEKDYYFPH*MVL
ALLHKINCP*IIWVYFLILSSFL*SVCLCLL*YH
TVLIIVAL**ILKSASVSPLSLFFFFNITLSIR
SLLHYNMNFKIF

Frame 2

ADHQCGRSQPTSDHPELVQAGPQAVQDPSPLCD
SLPLLSW*VCK*CPSRS*QVQILTPGEDGCLRN
SSSLAHRRQRDMQ*EEYQLA*LRHVAALRN*QV
PRGRVCVLPTG*RK*QCGFC*CGGG*LGCLVGRS
RHRLCRWE*RQSSRSSRGGRSG*GGRRRSR**R
GR*GW**GRGRG*GTLRRSHRENHQHCHHHHHH
HRVCGRGGSRGVL*TSRDGAVPSNDLPLVL*CD*
REVCPILLRRMWRQPEQL*HRRVLHGRVWQRH
S
YNSSQYP*CR*QVSRDTWG*E*TCPFPESQREA
*GQAPRENVPGHERMGRGRTSSKELA*S**EGSY
PAFPGESGIFGTGSSQRETAAGGDTHGQSGSHA
Q*PPPPGPGELHHRSAGCSSSASSRVQYAKEVC
PRRTEGQTAHPKAFRACAHGGSQESRSDPVPGYD
TPPCDL*AHESVSLPALQRACSGRGDSG*SWCS
GSCL*FQHFGRPRWADDLSPEVQDQNGKHGKTT
FLQKNYPGMITSICSPSYSGGCGGRIS*AWGG*G
CSEP*SRHLGNRARPCLKKRKKKTIISPIEWSW
HYYTKSIVHR*YGFIS*FLVLFFDLCACAYCST
TLF*LL*LCSKF*NQQV*VRYLCSSFSILL*VSG
VSCITT*ILRSS

Sequence APP.bAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG
GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG
ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA
TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA
AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG
GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA
AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA
CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT
GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG
TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA
GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC
CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAG
AAGAGTACTGCATGGCCGTGTGTGGCAGCGCCA
TTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAA
TGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAA
GCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGC
TGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCG
GCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGAT
CCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTG
CAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGAT
CAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAG
CCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC
GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCA
AAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACC
TTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGC
AGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTG
CTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACA
CAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGT
ACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGT
TTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATT
CCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT
GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAG
CTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTG
CTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACAT
AAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGA
TTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAA
ACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT
  • APP.F7 (forward primer)
  • APP.R2 (reverse primer)
  • Single exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR
GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR
CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR
LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR
KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG
AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA
NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM
TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM
RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK
WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ
REPPALPPPPPPPQSLWKRWFERCALNKPRRGRA
EQ*SPAGTLM*LKGSVPHSFTADVAATGTTLTQ
KSTAWPCVAAP
FLQQQPVPLMPLTSISRHLGMR
MNMPISRKPKRGLRPSTERECPRS*ENGKRQNVK
QRTCLKLIRRQLSSISRRKWNLWNRKQPTRDSS
WWRHTWPEWKPCSMTAAAWPWRTTSPLCRLFLL
GLVTCSIC*RSMSAQNRRTDSTP*SISSMCAWWI
PRKPLRSGPRL*HTSV*FMSA*ISLSPCSTTCL
QWPRRFRMKLMSCFRKSKTIQMTSWPT*LVNQG
SVTETMLSCHL*PKRKPPWSSFP*MESSAWTISS
RGILLGLTLCQPTQKTKLSLLMPALLPTED*PL
DQVLG*QISRRRRSLK*RWMQNSDMTQDMKFII
KNWCSLQKMWVQTKVQSLDSWWAVLS*RQ*SSSP
W*C*RRNSTHPFIMVWWRLTPLSPQRSATCPRC
SRTATKIQPTSSLSRCRTRPPPQQPLKLDSKTI
ASLPIGVHL*NNVGRNKPVL*FTHYRLLTAVL*H
K*MPELELIHTSVMYSISLYILVSILHY*WVLC
TVKNLAVSN*CMNRFSPDYLSHSPLASCILFLW
FVTQLSPTLHML*ESMGDASCERGSSAASLA*VF
LS*SLCILKLNIFKYFRCFREIFFP*LHFTVQI
AASAIFVI*ELRGYTRLFLRACFMCTH*ALRLQ
AFLFLSTYLWVFDKEKNPCSL*ALLRGGWGGVLC
WSSITKNSPKQFSAG*LYRIIAYDMIAFYTVLH
K*IK*NNPGQDFSLKDDYRH*IIEVILGGEKRQ
IQFSLTSLKFHL*YKRR*KWKWQYKGMRKACLDK
PFF*DVSSICIKWCFHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA
GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR
DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD
CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG
RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA
GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ
ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA*
LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC*
CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS
G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR
ENHQHCHHHHHHHRVCGRGGSRGVL*TSRDGAV
PSNDLPLVL*CD*REVCPILLRRMWRQPEQL*HR
RVLHGRVWQRH
SYNSSQYP*CR*QVSRDTWG*E
*TCPFPESQREA*GQAPRENVPGHERMGRGRTS
SKELA*S**EGSYPAFPGESGIFGTGSSQRETAA
GGDTHGQSGSHAQ*PPPPGPGELHHRSAGCSSS
ASSRVQYAKEVCPRRTEGQTAHPKAFRACAHGG
SQESRSDPVPGYDTPPCDL*AHESVSLPALQRAC
SGRGDSG*S**AASERAKLFR*RLGQHD**TKD
QLRKRCSHAIFDRNENHRGAPSREWRVQPGRSP
AVAFFWG*LCASQHRKRS*AC*CPPCCRPRTDHS
TRFWVDKYQDGGDL*SEDGCRIPT*LRI*SSSS
KIGVLCRRCGFKQRCNHWTHGGRCCHSDSDRHH
LGDAEEETVHIHSSWCGGG*RRCHPRGAPPVQDA
AERLRKSNLQVL*ADAELDPRHSSL*SWTAKPL
LHYPSVSIYRIMWEETNPFYDLLIIAF*QLCCN
TSRCLNLN*STHQ*CILSLFTFWSLYYIINGFCV
L*RI*LYQTSA*IDSLLIIYHIAP*PVVYYSCG
L*PN*VLLYICFKNRWGMLHVNVGVQLLLLPKY
SFPDHYAF*S*TFLSISDALERFFFHDCILLYRL
LLLLYL*YRN*EDTHVCFFVPVLCAHIRH*DFK
LFFFCPRIFGSLIKKRIPVHCKHFYGAGGEGCS
AGLQLPRILQNNFLQDDCTESLLMT*SLSTLYYI
NKLNKITPGKTFL*RMTTDIK*SK*FWVGRRGR
FNFL*PV*SFIYDTKEDENGSGNIRG*GRHAWT
NPSFKMCLQFV*NGVFM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR
GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ
IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE
GILQYCQEVYPELQITNVVEANQPVTIQNWCKR
GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC
KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD
YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD
AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE
VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE
RTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT
EEYCMAVCGSA
IPTTAASTPDAVDKYLETPGDEN
EHAHFQKAKERLEAKHRERMSQVMREWEEAERQ
AKNLPKADKKAVIQHFQEKVESLEQEAANERQQ
LVETHMARVEAMLNDRRRLALENYITALQAVPPR
PRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVD
PKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP
AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRI
SYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ
PWHSFGADSVPANTENEVEPVDARPAADRGLTT
RPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQ
KLVFFAEDVGSNKGAIIGLMVGGVVIATVIVIT
LVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKM
QQNGYENPTYKFFEQMQN*TPATAASEVGQQNHC
FTTHRCPFIE*CGKKQTRFMIYSLSPFDSCAVT
QVDA*T*INPHISNVFYLSLHFGLYTTLLMGFV
YCKEFSCIKLVHE*ILS*LFIT*PLSQLYIILVV
CDPIKSYFTYALRIDGGCFM*TWEFSCFSCLSI
PFLITMHFKVKHF*VFQML*RDFFSMTAFYCTD
CCFCYICDIGIKRIHTFVSSCLFYVHTLGIETSS
FSFFVHVSLGL**RKESLFIVSTFTGRVGRGAL
LVFNYQEFSKTIFCRMIVQNHCL*HDRFLHCIT
*IN*IK*PRARLFFEG*LQTLNNRSNFGWGEEAD
SIFFNQSEVSFMIQKKMKMEVAI*GDEEGMPGQ
TLLLRCVFNLYKMVFSCK*IHSWRST

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