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Sequences

Sequence VDR.bAug05

CTGCTTGTCAAAAGGCGGCAGCGGAGCCGTGTGCGCCGGGAGCGCGGAACAGCTTGTCCACCCGCCGGCCGGACCAGGGCTCCTGAACCTAGCCCAGCTG GACGGAGAAATGGACTCTAGCCTCCTCTGATAGCCTCATGCCAGGCCCCGTGCACATTGCTTTGCTTGCCTCCCTCAATCCTCATAGCTTCTCTTTGGGA AGCCTTTGGGTCTGAAGTGTCTGTGAGACCTCACAGAAGAGCACCCCTGGGCTCCACTTACCTGCCCCCTGCTCCTTCAGGGATGGAGGCAATGGCGGCC AGCACTTCCCTGCCTGACCCTGGAGACTTTGACCGGAACGTGCCCCGGATCTGTGGGGTGTGTGGAGACCGAGCCACTGGCTTTCACTTCAATGCTATGA CCTGTGAAGGCTGCAAAGGCTTCTTCAGGCGAAGCATGAAGCGGAAGGCACTATTCACCTGCCCCTTCAACGGGGACTGCCGCATCACCAAGGACAACCG ACGCCACTGCCAGGCCTGCCGGCTCAAACGCTGTGTGGACATCGGCATGATGAAGGAGTTCATTCTGACAGATGAGGAAGTGCAGAGGAAGCGGGAGATG ATCCTGAAGCGGAAGGAGGAGGAGGCCTTGAAGGACAGTCTGCGGCCCAAGCTGTCTGAGGAGCAGCAGCGCATCATTGCCATACTGCTGGACGCCCACC ATAAGACCTACGACCCCACCTACTCCGACTTCTGCCAGTTCCGGCCTCCAGTTCGTGTGAATGATGGTGGAGGGAGCCATCCTTCCAGGCCCAACTCCAG ACACACTCCCAGCTTCTCTGGGGACTCCTCCTCCTCCTGCTCAGATCACTGTATCACCTCTTCAGACATGATGGACTCGTCCAGCTTCTCCAATCTGGAT CTGAGTGAAGAAGATTCAGATGACCCTTCTGTGACCCTAGAGCTGTCCCAGCTCTCCATGCTGCCCCACCTGGCTGACCTGGTCAGTTACAGCATCCAAA AGGTCATTGGCTTTGCTAAGATGATACCAGGATTCAGAGACCTCACCTCTGAGGACCAGATCGTACTGCTGAAGTCAAGTGCCATTGAGGTCATCATGTT GCGCTCCAATGAGTCCTTCACCATGGACGACATGTCCTGGACCTGTGGCAACCAAGACTACAAGTACCGCGTCAGTGACGTGACCAAAGCCGGACACAGC CTGGAGCTGATTGAGCCCCTCATCAAGTTCCAGGTGGGACTGAAGAAGCTGAACTTGCATGAGGAGGAGCATGTCCTGCTCATGGCCATCTGCATCGTCT CCCCAGATCGTCCTGGGGTGCAGGACGCCGCGCTGATTGAGGCCATCCAGGACCGCCTGTCCAACACACTGCAGACGTACATCCGCTGCCGCCACCCGCC CCCGGGCAGCCACCTGCTCTATGCCAAGATGATCCAGAAGCTAGCCGACCTGCGCAGCCTCAATGAGGAGCACTCCAAGCAGTACCGCTGCCTCTCCTTC CAGCCTGAGTGCAGCATGAAGCTAACGCCCCTTGTGCTCGAAGTGTTTGGCAATGAGATCTCCTGACTAGGACAGCCTGTGGCGGTGCCTGGGTGGGGCT GCTCCTCCAGGGCCACGTGCCAGGCCCGGGGCTGGCGGCTACTCAGCAGCCCTCCTCACCCCGTCTGGGGTTCAGCCCCTCCTCTGCCACCTCCCCTATC CACCCAGCCCATTCTCTCTCCTGTCCAACCTAACCCCTTTCCTGCGGGCTTTTCCCCGGTCCCTTGAGACCTCAGCCATGAGGAGTTGCTGTTTGTTTGA CAAAGAAACCCAAGTGGGGGCAGAGGGCAGAGGCTGGAGGCAGGGCCTTGCCCAGAGATGCCTCCACCGCTGCCTAAGTGGCTGCTGACTGATGTTGAGG GAACAGACAGGAGAAATGCATCCATTCCTCAGGGACAGAGACACCTGCACCTCCCCCCACTGCAGGCCCCGCTTGTCCAGCGCCTAGTGGGGTCTCCCTC TCCTGCCTACTCACGATAAATAATCGGCCCACAGCTCCCACCCCACCCCCTTCAGTGCCCACCAACATCCCATTGCCCTGGTTATATTCTCACGGGCAGT AGCTGTGGTGAGGTGGGTTTTCTTCCCATCACTGGAGCACCAGGCACGAACCCACCTGCTGAGAGACCCAAGGAGGAAAAACAGACAAAAACAGCCTCAC AGAAGAATATGACAGCTGTCCCTGTCACCAAGCTCACAGTTCCTCGCCCTGGGTCTAAGGGGTTGGTTGAGGTGGAAGCCCTCCTTCCACGGATCCATGT AGCAGGACTGAATTGTCCCCAGTTTGCAGAAAAGCACCTGCCGACCTCGTCCTCCCCCTGCCAGTGCCTTACCTCCTGCCCAGGAGAGCCAGCCCTCCCT GTCCTCCTCGGATCACCGAGAGTAGCCGAGAGCCTGCTCCCCCACCCCCTCCCCAGGGGAGAGGGTCTGGAGAAGCAGTGAGCCGCATCTTCTCCATCTG GCAGGGTGGGATGGAGGAGAAGAATTTTCAGACCCCAGCGGCTGAGTCATGATCTCCCTGCCGCCTCAATGTGGTTGCAAGGCCGCTGTTCACCCACAGG GCTAAGAGCTAGCGCTGCCGCACCCCAGAGTGTGGGAAGGGAGAGCGGGGCAGTCTCGGGTGGCTAGTCAGAGAGAGTGTTTGGGGGTTCCGTGATGTAG GGTAAGGTGCCTTCTTATTCTCACTCCACCACCCAAAAGTCAAAAGGTGCCTGTGAGGCAGGGGCGGAGTGATACAACTTCAAGTGCATGCTCTCTGCAG CCAGCCCAGCCCAGCTGGTGGGAAGCGTCTGTCCGTTTACTCCAAGGTGGGGTCTTTGTGAGAGTGAGCTGTAGGTGTGCGGGACCGGTACAGAAAGGCG TTCTTCGAGGTGGATCACAGAGGCTTCTTCAGATCAGTGCTTGAGTTTGGGGAATGCGGCCGCATTCCCTGAGTCACCAGGAATGTTAAAGTCAGTGGGA ACGTGACTGCCCCAACTCCTGGAAGCTGTGTCCTTGCACCTGCATCCGTAGTTCCCTGAAAACCCAGAGAGGAATCAGACTTCACACTGCAAGAGCCTTG GTGTCCACCTGGCCCCATGTCTCTCAGAATTCTTCAGGTGGAAAAACATCTGAAAGCCACGTTCCTTACTGCAGAATAGCATATATATCGCTTAATCTTA AATTTATTAGATATGAGTTGTTTTCAGACTCAGACTCCATTTGTATTATAGTCTAATATACAGGGTAGCAGGTACCACTGATTTGGAGATATTTATGGGG GGAGAACTTACATTGTGAAACTTCTGTACATTAATTATTATTGCTGTTGTTATTTTACAAGGGTCTAGGGAGAGACCCTTGTTTGATTTTAGCTGCAGAA CGTATTGGTCCAGCTTGCTCTTCAGTGGGAGAAAACACTTGTAAGTTGCTAAACGAGTCAATCCCCTCATTCAGGAAAACTGACAGAGGAGGGCGTGACT CACCCAAGCATATATAACTAGCTAGAAGTGGGCCAGGACAGGCCCGGCGCGGTGGCTCACGCCTGTAATCCCAGCAGTTTGGGAGGTCGAGGTAGGTGGA TCACCTGAGGTCGGGAGTTCGAGACCAACCTGACCAACATGGAGAAACCCTGTCTCTATTAAAAATACAAAAAAAAAAAAAAAAAAAATAGCCGGGCATG GTGGCGCAAGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGTGCCGTTACTCT CCAACCTGGACAACAAGAGCGAAACTCCGTCTTAGAAGTGGACCAGGACAGGACCAGATTTTGGAGTCATGGTCCGGTGTCCTTTTCACTACACCATGTT TGAGCTCAGACCCCCACTCTCATTCCCCAGGTGGCTGACCCAGTCCCTGGGGGAAGCCCTGGATTTCAGAAAGAGCAAGTCTGGATCTGGGACCCTTTCC TTCCTTCCCTGGCTTGTAACTCCACCAACCCATCAGAAGGAGAAGGAAGGAGACTCACCTCTGCCTCAATGTGAATCAGACCCTACCCCACCACGATGTG GCCCTGGCCTGCTGGGCTCTCCACCTCAGCCTTGGATAATGCTGTTGCCTCATCTATAACATGCATTTGTCTTTGTAATGTCACCACCTTCCCAGCTCTC CCTCTGGCCCTGCCTTCTTCGGGGAACTCCTGGAAATATCAGTTACTCAGCCCTGGGCCCCACCACCTAGGCCACTCCTCCAAAGGAAGTCTAGGAGCTG GGAGGAAAAGAAAAGAGGGGAAAATGAGTTTTTATGGGGCTGAACGGGGAGAAAAGGTCATCATCGATTCTACTTTAGAATGAGAGTGTGAAATAGACAT TTGTAAATGTAAAACTTTTAAGGTATATCATTATAACTGAAGGAGAAGGTGCCCCAAAATGCAAGATTTTCCACAAGATTCCCAGAGACAGGAAAATCCT CTGGCTGGCTAACTGGAAGCATGTAGGAGAATCCAAGCGAGGTCAACAGAGAAGGCAGGAATGTGTGGCAGATTTAGTGAAAGCTAGAGATATGGCAGCG AAAGGATGTAAACAGTGCCTGCTGAATGATTTCCAAAGAGAAAAAAAGTTTGCCAGAAGTTTGTCAAGTCAACCAATGTAGAAAGCTTTGCTTATGGTAA TAAAAATGGCTCATACTTATATAGCACTTACTTTGTTGCAAGTACTGCTGTAAATAAATGCTTTATGCAAACCAA

VDR.F2 (forward primer)
VDR.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

LLVKRRQRSRVRRERGTACPPAGRTRAPEPSPA GRRNGL*PPLIASCQAPCTLLCLPPSILIASLWE AFGSEVSVRPHRRAPLGSTYLPPAPSGMEAMAA STSLPDPGDFDRNVPRICGVCGDRATGFHFNAM TCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNR RHCQACRLKRCVDIGMMKEFILTDEEVQRKREM ILKRKEEEALKDSLRPKLSEEQQRIIAILLDAH HKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSR HTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLD LSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQ KVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIML RSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHS LELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV SPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPP PGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSF QPECSMKLTPLVLEVFGNEIS*LGQPVAVPGWG CSSRATCQARGWRLLSSPPHPVWGSAPPLPPPLS TQPILSPVQPNPFPAGFSPVP*DLSHEELLFV* QRNPSGGRGQRLEAGPCPEMPPPLPKWLLTDVE GTDRRNASIPQGQRHLHLPPLQAPLVQRLVGSPS PAYSR*IIGPQLPPHPLQCPPTSHCPGYILTGS SCGEVGFLPITGAPGTNPPAERPKEEKQTKTAS QKNMTAVPVTKLTVPRPGSKGLVEVEALLPRIHV AGLNCPQFAEKHLPTSSSPCQCLTSCPGEPALP VLLGSPRVAESLLPHPLPRGEGLEKQ*AASSPS GRVGWRRRIFRPQRLSHDLPAASMWLQGRCSPTG LRASAAAPQSVGRESGAVSGG*SERVFGGSVM* GKVPSYSHSTTQKSKGACEAGAE*YNFKCMLSA ASPAQLVGSVCPFTPRWGLCESEL*VCGTGTERR SSRWITEASSDQCLSLGNAAAFPESPGMLKSVG T*LPQLLEAVSLHLHP*FPENPERNQTSHCKSL GVHLAPCLSEFFRWKNI*KPRSLLQNSIYIA*S* IY*I*VVFRLRLHLYYSLIYRVAGTTDLEIFMG GELTL*NFCTLIIIAVVILQGSRERPLFDFSCR TYWSSLLFSGRKHL*VAKRVNPLIQEN*QRRA*L TQAYITS*KWARTGPARWLTPVIPAVWEVEVGG SPEVGSSRPT*PTWRNPVSIKNTKKKKKKIAGH GGASL*SQLLRRLRQKN*TQEVEVAVS*DRAVTL QPGQQERNSVLEVDQDRTRFWSHGPVSFSLHHV *AQTPTLIPQVADPVPGGSPGFQKEQVWIWDPF LPSLACNSTNPSEGEGRRLTSASM*IRPYPTTMW PWPAGLSTSALDNAVASSITCICLCNVTTFPAL PLALPSSGNSWKYQLLSPGPHHLGHSSKGSLGA GRKRKEGKMSFYGAERGEKVIIDSTLE*ECEIDI CKCKTFKVYHYN*RRRCPKMQDFPQDSQRQENP LAG*LEACRRIQARSTEKAGMCGRFSES*RYGS ERM*TVPAE*FPKRKKVCQKFVKSTNVESFAYGN KNGSYLYSTYFVASTAVNKCFMQT

Frame 1

CLSKGGSGAVCAGSAEQLVHPPAGPGLLNLAQL DGEMDSSLL**PHARPRAHCFACLPQSS*LLFG KPLGLKCL*DLTEEHPWAPLTCPLLLQGWRQWRP ALPCLTLETLTGTCPGSVGCVETEPLAFTSML* PVKAAKASSGEA*SGRHYSPAPSTGTAASPRTT DATARPAGSNAVWTSA**RSSF*QMRKCRGSGR* S*SGRRRRP*RTVCGPSCLRSSSASLPYCWTPT IRPTTPPTPTSASSGLQFV*MMVEGAILPGPTP DTLPASLGTPPPPAQITVSPLQT*WTRPASPIWI *VKKIQMTLL*P*SCPSSPCCPTWLTWSVTASK RSLALLR*YQDSETSPLRTRSYC*SQVPLRSSC CAPMSPSPWTTCPGPVATKTTSTASVT*PKPDTA WS*LSPSSSSRWD*RS*TCMRRSMSCSWPSASS PQIVLGCRTPR*LRPSRTACPTHCRRTSAAATR PRAATCSMPR*SRS*PTCAASMRSTPSSTAASPS SLSAA*S*RPLCSKCLAMRSPD*DSLWRCLGGA APPGPRARPGAGGYSAALLTPSGVQPLLCHLPY PPSPFSLLSNLTPFLRAFPRSLETSAMRSCCLFD KETQVGAEGRGWRQGLAQRCLHRCLSGC*LMLR EQTGEMHPFLRDRDTCTSPHCRPRLSSA*WGLP LLPTHDK*SAHSSHPTPFSAHQHPIALVIFSRAV AVVRWVFFPSLEHQARTHLLRDPRRKNRQKQPH RRI*QLSLSPSSQFLALGLRGWLRWKPSFHGSM *QD*IVPSLQKSTCRPRPPPASALPPAQESQPSL SSSDHRE*PRACSPTPSPGERVWRSSEPHLLHL AGWDGGEEFSDPSG*VMISLPPQCGCKAAVHPQ G*ELALPHPRVWEGRAGQSRVASQRECLGVP*CR VRCLLILTPPPKSQKVPVRQGRSDTTSSACSLQ PAQPSWWEASVRLLQGGVFVRVSCRCAGPVQKG VLRGGSQRLLQISA*VWGMRPHSLSHQEC*SQWE RDCPNSWKLCPCTCIRSSLKTQRGIRLHTARAL VSTWPHVSQNSSGGKTSESHVPYCRIAYISLNL KFIRYELFSDSDSICIIV*YTG*QVPLIWRYLWG ENLHCETSVH*LLLLLLFYKGLGRDPCLILAAE RIGPACSSVGENTCKLLNESIPSFRKTDRGGRD SPKHI*LARSGPGQARRGGSRL*SQQFGRSR*VD HLRSGVRDQPDQHGETLSLLKIQKKKKKK*PGM VAQACNPSYSGG*GRRIEPRRWRLQ*AEIVPLL SNLDNKSETPS*KWTRTGPDFGVMVRCPFHYTMF ELRPPLSFPRWLTQSLGEALDFRKSKSGSGTLS FLPWLVTPPTHQKEKEGDSPLPQCESDPTPPRC GPGLLGSPPQPWIMLLPHL*HAFVFVMSPPSQLS LWPCLLRGTPGNISYSALGPTT*ATPPKEV*EL GGKEKRGK*VFMGLNGEKRSSSILL*NESVK*T FVNVKLLRYIIITEGEGAPKCKIFHKIPRDRKIL WLANWKHVGESKRGQQRRQECVADLVKARDMAA KGCKQCLLNDFQREKKFARSLSSQPM*KALLMV IKMAHTYIALTLLQVLL*INALCKP

Frame 2

ACQKAAAEPCAPGARNSLSTRRPDQGS*T*PSW TEKWTLASSDSLMPGPVHIALLASLNPHSFSLG SLWV*SVCETSQKSTPGLHLPAPCSFRDGGNGG QHFPA*PWRL*PERAPDLWGVWRPSHWLSLQCYD L*RLQRLLQAKHEAEGTIHLPLQRGLPHHQGQP TPLPGLPAQTLCGHRHDEGVHSDR*GSAEEAGD DPEAEGGGGLEGQSAAQAV*GAAAHHCHTAGRPP *DLRPHLLRLLPVPASSSCE*WWREPSFQAQLQ THSQLLWGLLLLLLRSLYHLFRHDGLVQLLQSG SE*RRFR*PFCDPRAVPALHAAPPG*PGQLQHPK GHWLC*DDTRIQRPHL*GPDRTAEVKCH*GHHV ALQ*VLHHGRHVLDLWQPRLQVPRQ*RDQSRTQ PGAD*APHQVPGGTEEAELA*GGACPAHGHLHRL PRSSWGAGRRAD*GHPGPPVQHTADVHPLPPPA PGQPPALCQDDPEASRPAQPQ*GALQAVPLPLL PA*VQHEANAPCARSVWQ*DLLTRTACGGAWVGL LLQGHVPGPGLAATQQPSSPRLGFSPSSATSPI HPAHSLSCPT*PLSCGLFPGPLRPQP*GVAVCL TKKPKWGQRAEAGGRALPRDASTAA*VAAD*C*G NRQEKCIHSSGTETPAPPPTAGPACPAPSGVSL SCLLTINNRPTAPTPPPSVPTNIPLPWLYSHGQ *LW*GGFSSHHWSTRHEPTC*ETQGGKTDKNSLT EEYDSCPCHQAHSSSPWV*GVG*GGSPPSTDPC SRTELSPVCRKAPADLVLPLPVPYLLPRRASPP CPPRITESSREPAPPPPPQGRGSGEAVSRIFSIW QGGMEEKNFQTPAAES*SPCRLNVVARPLFTHR AKS*RCRTPECGKGERGSLGWLVRESVWGFRDV G*GAFLFSLHHPKVKRCL*GRGGVIQLQVHALCS QPSPAGGKRLSVYSKVGSL*E*AVGVRDRYRKA FFEVDHRGFFRSVLEFGECGRIP*VTRNVKVSG NVTAPTPGSCVLAPASVVP*KPREESDFTLQEPW CPPGPMSLRILQVEKHLKATFLTAE*HIYRLIL NLLDMSCFQTQTPFVL*SNIQGSRYH*FGDIYG GRTYIVKLLYINYYCCCYFTRV*GETLV*F*LQN VLVQLALQWEKTLVSC*TSQSPHSGKLTEEGVT HPSIYN*LEVGQDRPGAVAHACNPSSLGGRGRW IT*GREFETNLTNMEKPCLY*KYKKKKKKNSRAW WRKPVIPATQEAEAEELNPGGGGCSELRSCRYS PTWTTRAKLRLRSGPGQDQILESWSGVLFTTPC LSSDPHSHSPGG*PSPWGKPWISERASLDLGPFP SFPGL*LHQPIRRRRKETHLCLNVNQTLPHHDV ALACWALHLSLG*CCCLIYNMHLSL*CHHLPSS PSGPAFFGELLEISVTQPWAPPPRPLLQRKSRSW EEKKRGENEFLWG*TGRKGHHRFYFRMRV*NRH L*M*NF*GISL*LKEKVPQNARFSTRFPETGKS SGWLTGSM*ENPSEVNREGRNVWQI**KLEIWQR KDVNSAC*MISKEKKSLPEVCQVNQCRKLCLW* *KWLILI*HLLCCKYCCK*MLYANQ

Sequence VDR.aAug05

GTGTGCGCCGGGAGCGCGGAACAGCTTGTCCACCCGCCGGCCGGACCAGGTGCGAACCCGGGAGCAGCGGGAAAGGGGGTCTCAGGATAGGGACTCGGGG TCGGGGCGTCTGGGATACCGGGGCCTGAGCGCCCGGCTGCGAGCATTAGAGTCTAAGTCTCAGCGGTAAACTTGGCTACTGAGGTCCGGGCTGTCGTGCC ATGAGGCTGGGACACTAAGGGGCACTGAGGTTTGAGAAAGCTGAAGTTCGTGCCAGGCTGGCGAGGGGAGCAGCGACATCCTCGGCGCTTAGGAGAAATG CTCCGCTAACACAGTGCTTAGCACTTGGGCAACAAGAAGTATTTGTTTCCTTCTTCTGTCGGGGCGCCTTGGCATGGAGTGGAGGAATAAGAAAAGGAGC GATTGGCTGTCGATGGTGCTCAGAACTGCTGGAGTGGAGGAAGCCTTTGGGTCTGAAGTGTCTGTGAGACCTCACAGAAGAGCACCCCTGGGCTCCACTT ACCTGCCCCCTGCTCCTTCAGGGATGGAGGCAATGGCGGCCAGCACTTCCCTGCCTGACCCTGGAGACTTTGACCGGAACGTGCCCCGGATCTGTGGGGT GTGTGGAGACCGAGCCACTGGCTTTCACTTCAATGCTATGACCTGTGAAGGCTGCAAAGGCTTCTTCAGGCGAAGCATGAAGCGGAAGGCACTATTCACC TGCCCCTTCAACGGGGACTGCCGCATCACCAAGGACAACCGACGCCACTGCCAGGCCTGCCGGCTCAAACGCTGTGTGGACATCGGCATGATGAAGGAGT TCATTCTGACAGATGAGGAAGTGCAGAGGAAGCGGGAGATGATCCTGAAGCGGAAGGAGGAGGAGGCCTTGAAGGACAGTCTGCGGCCCAAGCTGTCTGA GGAGCAGCAGCGCATCATTGCCATACTGCTGGACGCCCACCATAAGACCTACGACCCCACCTACTCCGACTTCTGCCAGTTCCGGCCTCCAGTTCGTGTG AATGATGGTGGAGGGAGCCATCCTTCCAGGCCCAACTCCAGACACACTCCCAGCTTCTCTGGGGACTCCTCCTCCTCCTGCTCAGATCACTGTATCACCT CTTCAGACATGATGGACTCGTCCAGCTTCTCCAATCTGGATCTGAGTGAAGAAGATTCAGATGACCCTTCTGTGACCCTAGAGCTGTCCCAGCTCTCCAT GCTGCCCCACCTGGCTGACCTGGTCAGTTACAGCATCCAAAAGGTCATTGGCTTTGCTAAGATGATACCAGGATTCAGAGACCTCACCTCTGAGGACCAG ATCGTACTGCTGAAGTCAAGTGCCATTGAGGTCATCATGTTGCGCTCCAATGAGTCCTTCACCATGGACGACATGTCCTGGACCTGTGGCAACCAAGACT ACAAGTACCGCGTCAGTGACGTGACCAAAGCCGGACACAGCCTGGAGCTGATTGAGCCCCTCATCAAGTTCCAGGTGGGACTGAAGAAGCTGAACTTGCA TGAGGAGGAGCATGTCCTGCTCATGGCCATCTGCATCGTCTCCCCAGATCGTCCTGGGGTGCAGGACGCCGCGCTGATTGAGGCCATCCAGGACCGCCTG TCCAACACACTGCAGACGTACATCCGCTGCCGCCACCCGCCCCCGGGCAGCCACCTGCTCTATGCCAAGATGATCCAGAAGCTAGCCGACCTGCGCAGCC TCAATGAGGAGCACTCCAAGCAGTACCGCTGCCTCTCCTTCCAGCCTGAGTGCAGCATGAAGCTAACGCCCCTTGTGCTCGAAGTGTTTGGCAATGAGAT CTCCTGACTAGGACAGCCTGTGGCGGTGCCTGGGTGGGGCTGCTCCTCCAGGGCCACGTGCCAGGCCCGGGGCTGGCGGCTACTCAGCAGCCCTCCTCAC CCCGTCTGGGGTTCAGCCCCTCCTCTGCCACCTCCCCTATCCACCCAGCCCATTCTCTCTCCTGTCCAACCTAACCCCTTTCCTGCGGGCTTTTCCCCGG TCCCTTGAGACCTCAGCCATGAGGAGTTGCTGTTTGTTTGACAAAGAAACCCAAGTGGGGGCAGAGGGCAGAGGCTGGAGGCAGGGCCTTGCCCAGAGAT GCCTCCACCGCTGCCTAAGTGGCTGCTGACTGATGTTGAGGGAACAGACAGGAGAAATGCATCCATTCCTCAGGGACAGAGACACCTGCACCTCCCCCCA CTGCAGGCCCCGCTTGTCCAGCGCCTAGTGGGGTCTCCCTCTCCTGCCTACTCACGATAAATAATCGGCCCACAGCTCCCACCCCACCCCCTTCAGTGCC CACCAACATCCCATTGCCCTGGTTATATTCTCACGGGCAGTAGCTGTGGTGAGGTGGGTTTTCTTCCCATCACTGGAGCACCAGGCACGAACCCACCTGC TGAGAGACCCAAGGAGGAAAAACAGACAAAAACAGCCTCACAGAAGAATATGACAGCTGTCCCTGTCACCAAGCTCACAGTTCCTCGCCCTGGGTCTAAG GGGTTGGTTGAGGTGGAAGCCCTCCTTCCACGGATCCATGTAGCAGGACTGAATTGTCCCCAGTTTGCAGAAAAGCACCTGCCGACCTCGTCCTCCCCCT GCCAGTGCCTTACCTCCTGCCCAGGAGAGCCAGCCCTCCCTGTCCTCCTCGGATCACCGAGAGTAGCCGAGAGCCTGCTCCCCCACCCCCTCCCCAGGGG AGAGGGTCTGGAGAAGCAGTGAGCCGCATCTTCTCCATCTGGCAGGGTGGGATGGAGGAGAAGAATTTTCAGACCCCAGCGGCTGAGTCATGATCTCCCT GCCGCCTCAATGTGGTTGCAAGGCCGCTGTTCACCCACAGGGCTAAGAGCTAGCGCTGCCGCACCCCAGAGTGTGGGAAGGGAGAGCGGGGCAGTCTCGG GTGGCTAGTCAGAGAGAGTGTTTGGGGGTTCCGTGATGTAGGGTAAGGTGCCTTCTTATTCTCACTCCACCACCCAAAAGTCAAAAGGTGCCTGTGAGGC AGGGGCGGAGTGATACAACTTCAAGTGCATGCTCTCTGCAGCCAGCCCAGCCCAGCTGGTGGGAAGCGTCTGTCCGTTTACTCCAAGGTGGGGTCTTTGT GAGAGTGAGCTGTAGGTGTGCGGGACCGGTACAGAAAGGCGTTCTTCGAGGTGGATCACAGAGGCTTCTTCAGATCAGTGCTTGAGTTTGGGGAATGCGG CCGCATTCCCTGAGTCACCAGGAATGTTAAAGTCAGTGGGAACGTGACTGCCCCAACTCCTGGAAGCTGTGTCCTTGCACCTGCATCCGTAGTTCCCTGA AAACCCAGAGAGGAATCAGACTTCACACTGCAAGAGCCTTGGTGTCCACCTGGCCCCATGTCTCTCAGAATTCTTCAGGTGGAAAAACATCTGAAAGCCA CGTTCCTTACTGCAGAATAGCATATATATCGCTTAATCTTAAATTTATTAGATATGAGTTGTTTTCAGACTCAGACTCCATTTGTATTATAGTCTAATAT ACAGGGTAGCAGGTACCACTGATTTGGAGATATTTATGGGGGGAGAACTTACATTGTGAAACTTCTGTACATTAATTATTATTGCTGTTGTTATTTTACA AGGGTCTAGGGAGAGACCCTTGTTTGATTTTAGCTGCAGAACGTATTGGTCCAGCTTGCTCTTCAGTGGGAGAAAACACTTGTAAGTTGCTAAACGAGTC AATCCCCTCATTCAGGAAAACTGACAGAGGAGGGCGTGACTCACCCAAGCATATATAACTAGCTAGAAGTGGGCCAGGACAGGCCCGGCGCGGTGGCTCA CGCCTGTAATCCCAGCAGTTTGGGAGGTCGAGGTAGGTGGATCACCTGAGGTCGGGAGTTCGAGACCAACCTGACCAACATGGAGAAACCCTGTCTCTAT TAAAAATACAAAAAAAAAAAAAAAAAAAATAGCCGGGCATGGTGGCGCAAGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGAACCCAG GAGGTGGAGGTTGCAGTGAGCTGAGATCGTGCCGTTACTCTCCAACCTGGACAACAAGAGCGAAACTCCGTCTTAGAAGTGGACCAGGACAGGACCAGAT TTTGGAGTCATGGTCCGGTGTCCTTTTCACTACACCATGTTTGAGCTCAGACCCCCACTCTCATTCCCCAGGTGGCTGACCCAGTCCCTGGGGGAAGCCC TGGATTTCAGAAAGAGCAAGTCTGGATCTGGGACCCTTTCCTTCCTTCCCTGGCTTGTAACTCCACCAACCCATCAGAAGGAGAAGGAAGGAGACTCACC TCTGCCTCAATGTGAATCAGACCCTACCCCACCACGATGTGGCCCTGGCCTGCTGGGCTCTCCACCTCAGCCTTGGATAATGCTGTTGCCTCATCTATAA CATGCATTTGTCTTTGTAATGTCACCACCTTCCCAGCTCTCCCTCTGGCCCTGCCTTCTTCGGGGAACTCCTGGAAATATCAGTTACTCAGCCCTGGGCC CCACCACCTAGGCCACTCCTCCAAAGGAAGTCTAGGAGCTGGGAGGAAAAGAAAAGAGGGGAAAATGAGTTTTTATGGGGCTGAACGGGGAGAAAAGGTC ATCATCGATTCTACTTTAGAATGAGAGTGTGAAATAGACATTTGTAAATGTAAAACTTTTAAGGTATATCATTATAACTGAAGGAGAAGGTGCCCCAAAA TGCAAGATTTTCCACAAGATTCCCAGAGACAGGAAAATCCTCTGGCTGGCTAACTGGAAGCATGTAGGAGAATCCAAGCGAGGTCAACAGAGAAGGCAGG AATGTGTGGCAGATTTAGTGAAAGCTAGAGATATGGCAGCGAAAGGATGTAAACAGTGCCTGCTGAATGATTTCCAAAGAGAAAAAAAGTTTGCCAGAAG TTTGTCAAGTCAACCAATGTAGAAAGCTTTGCTTATGGTAATAAAAATGGCTCATACTTATATAGCACTTACTTTGTTGCAAGTACTGCTGTAAATAAAT GCTTTATGCAAACCAA

VDR.F2 (forward primer)
VDR.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

VCAGSAEQLVHPPAGPGANPGAAGKGVSG*GLG VGASGIPGPERPAASIRV*VSAVNLATEVRAVVP *GWDTKGH*GLRKLKFVPGWRGEQRHPRRLGEM LR*HSA*HLGNKKYLFPSSVGAPWHGVEE*EKE RLAVDGAQNCWSGGSLWV*SVCETSQKSTPGLHL PAPCSFRDGGNGGQHFPA*PWRL*PERAPDLWG VWRPSHWLSLQCYDL*RLQRLLQAKHEAEGTIH LPLQRGLPHHQGQPTPLPGLPAQTLCGHRHDEGV HSDR*GSAEEAGDDPEAEGGGGLEGQSAAQAV* GAAAHHCHTAGRPP*DLRPHLLRLLPVPASSSC E*WWREPSFQAQLQTHSQLLWGLLLLLLRSLYHL FRHDGLVQLLQSGSE*RRFR*PFCDPRAVPALH AAPPG*PGQLQHPKGHWLC*DDTRIQRPHL*GP DRTAEVKCH*GHHVALQ*VLHHGRHVLDLWQPRL QVPRQ*RDQSRTQPGAD*APHQVPGGTEEAELA *GGACPAHGHLHRLPRSSWGAGRRAD*GHPGPP VQHTADVHPLPPPAPGQPPALCQDDPEASRPAQP Q*GALQAVPLPLLPA*VQHEANAPCARSVWQ*D LLTRTACGGAWVGLLLQGHVPGPGLAATQQPSS PRLGFSPSSATSPIHPAHSLSCPT*PLSCGLFPG PLRPQP*GVAVCLTKKPKWGQRAEAGGRALPRD ASTAA*VAAD*C*GNRQEKCIHSSGTETPAPPP TAGPACPAPSGVSLSCLLTINNRPTAPTPPPSVP TNIPLPWLYSHGQ*LW*GGFSSHHWSTRHEPTC *ETQGGKTDKNSLTEEYDSCPCHQAHSSSPWV* GVG*GGSPPSTDPCSRTELSPVCRKAPADLVLPL PVPYLLPRRASPPCPPRITESSREPAPPPPPQG RGSGEAVSRIFSIWQGGMEEKNFQTPAAES*SP CRLNVVARPLFTHRAKS*RCRTPECGKGERGSLG WLVRESVWGFRDVG*GAFLFSLHHPKVKRCL*G RGGVIQLQVHALCSQPSPAGGKRLSVYSKVGSL *E*AVGVRDRYRKAFFEVDHRGFFRSVLEFGECG RIP*VTRNVKVSGNVTAPTPGSCVLAPASVVP* KPREESDFTLQEPWCPPGPMSLRILQVEKHLKA TFLTAE*HIYRLILNLLDMSCFQTQTPFVL*SNI QGSRYH*FGDIYGGRTYIVKLLYINYYCCCYFT RV*GETLV*F*LQNVLVQLALQWEKTLVSC*TS QSPHSGKLTEEGVTHPSIYN*LEVGQDRPGAVAH ACNPSSLGGRGRWIT*GREFETNLTNMEKPCLY *KYKKKKKKNSRAWWRKPVIPATQEAEAEELNP GGGGCSELRSCRYSPTWTTRAKLRLRSGPGQDQI LESWSGVLFTTPCLSSDPHSHSPGG*PSPWGKP WISERASLDLGPFPSFPGL*LHQPIRRRRKETH LCLNVNQTLPHHDVALACWALHLSLG*CCCLIYN MHLSL*CHHLPSSPSGPAFFGELLEISVTQPWA PPPRPLLQRKSRSWEEKKRGENEFLWG*TGRKG HHRFYFRMRV*NRHL*M*NF*GISL*LKEKVPQN ARFSTRFPETGKSSGWLTGSM*ENPSEVNREGR NVWQI**KLEIWQRKDVNSAC*MISKEKKSLPE VCQVNQCRKLCLW**KWLILI*HLLCCKYCCK*M LYANQ

Frame 1

CAPGARNSLSTRRPDQVRTREQRERGSQDRDSG SGRLGYRGLSARLRALESKSQR*TWLLRSGLSC HEAGTLRGTEV*ES*SSCQAGEGSSDILGA*EKC SANTVLSTWATRSICFLLLSGRLGMEWRNKKRS DWLSMVLRTAGVEEAFGSEVSVRPHRRAPLGST YLPPAPSGMEAMAASTSLPDPGDFDRNVPRICGV CGDRATGFHFNAMTCEGCKGFFRRSMKRKALFT CPFNGDCRITKDNRRHCQACRLKRCVDIGMMKE FILTDEEVQRKREMILKRKEEEALKDSLRPKLSE EQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRV NDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCIT SSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSM LPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQ IVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQD YKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLH EEEHVLLMAICIVSPDRPGVQDAALIEAIQDRL SNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRS LNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEI S*LGQPVAVPGWGCSSRATCQARGWRLLSSPPH PVWGSAPPLPPPLSTQPILSPVQPNPFPAGFSP VP*DLSHEELLFV*QRNPSGGRGQRLEAGPCPEM PPPLPKWLLTDVEGTDRRNASIPQGQRHLHLPP LQAPLVQRLVGSPSPAYSR*IIGPQLPPHPLQC PPTSHCPGYILTGSSCGEVGFLPITGAPGTNPPA ERPKEEKQTKTASQKNMTAVPVTKLTVPRPGSK GLVEVEALLPRIHVAGLNCPQFAEKHLPTSSSP CQCLTSCPGEPALPVLLGSPRVAESLLPHPLPRG EGLEKQ*AASSPSGRVGWRRRIFRPQRLSHDLP AASMWLQGRCSPTGLRASAAAPQSVGRESGAVS GG*SERVFGGSVM*GKVPSYSHSTTQKSKGACEA GAE*YNFKCMLSAASPAQLVGSVCPFTPRWGLC ESEL*VCGTGTERRSSRWITEASSDQCLSLGNA AAFPESPGMLKSVGT*LPQLLEAVSLHLHP*FPE NPERNQTSHCKSLGVHLAPCLSEFFRWKNI*KP RSLLQNSIYIA*S*IY*I*VVFRLRLHLYYSLI YRVAGTTDLEIFMGGELTL*NFCTLIIIAVVILQ GSRERPLFDFSCRTYWSSLLFSGRKHL*VAKRV NPLIQEN*QRRA*LTQAYITS*KWARTGPARWL TPVIPAVWEVEVGGSPEVGSSRPT*PTWRNPVSI KNTKKKKKKIAGHGGASL*SQLLRRLRQKN*TQ EVEVAVS*DRAVTLQPGQQERNSVLEVDQDRTR FWSHGPVSFSLHHV*AQTPTLIPQVADPVPGGSP GFQKEQVWIWDPFLPSLACNSTNPSEGEGRRLT SASM*IRPYPTTMWPWPAGLSTSALDNAVASSI TCICLCNVTTFPALPLALPSSGNSWKYQLLSPGP HHLGHSSKGSLGAGRKRKEGKMSFYGAERGEKV IIDSTLE*ECEIDICKCKTFKVYHYN*RRRCPK MQDFPQDSQRQENPLAG*LEACRRIQARSTEKAG MCGRFSES*RYGSERM*TVPAE*FPKRKKVCQK FVKSTNVESFAYGNKNGSYLYSTYFVASTAVNK CFMQT

Frame 2

VRRERGTACPPAGRTRCEPGSSGKGGLRIGTRG RGVWDTGA*APGCEH*SLSLSGKLGY*GPGCRA MRLGH*GALRFEKAEVRARLARGAATSSALRRN APLTQCLALGQQEVFVSFFCRGALAWSGGIRKGA IGCRWCSELLEWRKPLGLKCL*DLTEEHPWAPL TCPLLLQGWRQWRPALPCLTLETLTGTCPGSVG CVETEPLAFTSML*PVKAAKASSGEA*SGRHYSP APSTGTAASPRTTDATARPAGSNAVWTSA**RS SF*QMRKCRGSGR*S*SGRRRRP*RTVCGPSCL RSSSASLPYCWTPTIRPTTPPTPTSASSGLQFV* MMVEGAILPGPTPDTLPASLGTPPPPAQITVSP LQT*WTRPASPIWI*VKKIQMTLL*P*SCPSSP CCPTWLTWSVTASKRSLALLR*YQDSETSPLRTR SYC*SQVPLRSSCCAPMSPSPWTTCPGPVATKT TSTASVT*PKPDTAWS*LSPSSSSRWD*RS*TC MRRSMSCSWPSASSPQIVLGCRTPR*LRPSRTAC PTHCRRTSAAATRPRAATCSMPR*SRS*PTCAA SMRSTPSSTAASPSSLSAA*S*RPLCSKCLAMR SPD*DSLWRCLGGAAPPGPRARPGAGGYSAALLT PSGVQPLLCHLPYPPSPFSLLSNLTPFLRAFPR SLETSAMRSCCLFDKETQVGAEGRGWRQGLAQR CLHRCLSGC*LMLREQTGEMHPFLRDRDTCTSPH CRPRLSSA*WGLPLLPTHDK*SAHSSHPTPFSA HQHPIALVIFSRAVAVVRWVFFPSLEHQARTHL LRDPRRKNRQKQPHRRI*QLSLSPSSQFLALGLR GWLRWKPSFHGSM*QD*IVPSLQKSTCRPRPPP ASALPPAQESQPSLSSSDHRE*PRACSPTPSPG ERVWRSSEPHLLHLAGWDGGEEFSDPSG*VMISL PPQCGCKAAVHPQG*ELALPHPRVWEGRAGQSR VASQRECLGVP*CRVRCLLILTPPPKSQKVPVR QGRSDTTSSACSLQPAQPSWWEASVRLLQGGVFV RVSCRCAGPVQKGVLRGGSQRLLQISA*VWGMR PHSLSHQEC*SQWERDCPNSWKLCPCTCIRSSL KTQRGIRLHTARALVSTWPHVSQNSSGGKTSESH VPYCRIAYISLNLKFIRYELFSDSDSICIIV*Y TG*QVPLIWRYLWGENLHCETSVH*LLLLLLFY KGLGRDPCLILAAERIGPACSSVGENTCKLLNES IPSFRKTDRGGRDSPKHI*LARSGPGQARRGGS RL*SQQFGRSR*VDHLRSGVRDQPDQHGETLSL LKIQKKKKKK*PGMVAQACNPSYSGG*GRRIEPR RWRLQ*AEIVPLLSNLDNKSETPS*KWTRTGPD FGVMVRCPFHYTMFELRPPLSFPRWLTQSLGEA LDFRKSKSGSGTLSFLPWLVTPPTHQKEKEGDSP LPQCESDPTPPRCGPGLLGSPPQPWIMLLPHL* HAFVFVMSPPSQLSLWPCLLRGTPGNISYSALG PTT*ATPPKEV*ELGGKEKRGK*VFMGLNGEKRS SSILL*NESVK*TFVNVKLLRYIIITEGEGAPK CKIFHKIPRDRKILWLANWKHVGESKRGQQRRQ ECVADLVKARDMAAKGCKQCLLNDFQREKKFARS LSSQPM*KALLMVIKMAHTYIALTLLQVLL*IN ALCKP