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Sequences

Sequence VDR.cAug05

CTGCTTGTCAAAAGGCGGCAGCGGAGCCGTGTGCGCCGGGAGCGCGGAACAGCTTGTCCACCCGCCGGCCGGACCAGAAGCCTTTGGGTCTGAAGTGTCT GTGAGACCTCACAGAAGAGCACCCCTGGGCTCCACTTACCTGCCCCCTGCTCCTTCAGGGATGGAGGCAATGGCGGCCAGCACTTCCCTGCCTGACCCTG GAGACTTTGACCGGAACGTGCCCCGGATCTGTGGGGTGTGTGGAGACCGAGCCACTGGCTTTCACTTCAATGCTATGACCTGTGAAGGCTGCAAAGGCTT CTTCAGGCGAAGCATGAAGCGGAAGGCACTATTCACCTGCCCCTTCAACGGGGACTGCCGCATCACCAAGGACAACCGACGCCACTGCCAGGCCTGCCGG CTCAAACGCTGTGTGGACATCGGCATGATGAAGGAGTTCATTCTGACAGATGAGGAAGTGCAGAGGAAGCGGGAGATGATCCTGAAGCGGAAGGAGGAGG AGGCCTTGAAGGACAGTCTGCGGCCCAAGCTGTCTGAGGAGCAGCAGCGCATCATTGCCATACTGCTGGACGCCCACCATAAGACCTACGACCCCACCTA CTCCGACTTCTGCCAGTTCCGGCCTCCAGTTCGTGTGAATGATGGTGGAGGGAGCCATCCTTCCAGGCCCAACTCCAGACACACTCCCAGCTTCTCTGGG GACTCCTCCTCCTCCTGCTCAGATCACTGTATCACCTCTTCAGACATGATGGACTCGTCCAGCTTCTCCAATCTGGATCTGAGTGAAGAAGATTCAGATG ACCCTTCTGTGACCCTAGAGCTGTCCCAGCTCTCCATGCTGCCCCACCTGGCTGACCTGGTCAGTTACAGCATCCAAAAGGTCATTGGCTTTGCTAAGAT GATACCAGGATTCAGAGACCTCACCTCTGAGGACCAGATCGTACTGCTGAAGTCAAGTGCCATTGAGGTCATCATGTTGCGCTCCAATGAGTCCTTCACC ATGGACGACATGTCCTGGACCTGTGGCAACCAAGACTACAAGTACCGCGTCAGTGACGTGACCAAAGCCGGACACAGCCTGGAGCTGATTGAGCCCCTCA TCAAGTTCCAGGTGGGACTGAAGAAGCTGAACTTGCATGAGGAGGAGCATGTCCTGCTCATGGCCATCTGCATCGTCTCCCCAGATCGTCCTGGGGTGCA GGACGCCGCGCTGATTGAGGCCATCCAGGACCGCCTGTCCAACACACTGCAGACGTACATCCGCTGCCGCCACCCGCCCCCGGGCAGCCACCTGCTCTAT GCCAAGATGATCCAGAAGCTAGCCGACCTGCGCAGCCTCAATGAGGAGCACTCCAAGCAGTACCGCTGCCTCTCCTTCCAGCCTGAGTGCAGCATGAAGC TAACGCCCCTTGTGCTCGAAGTGTTTGGCAATGAGATCTCCTGACTAGGACAGCCTGTGGCGGTGCCTGGGTGGGGCTGCTCCTCCAGGGCCACGTGCCA GGCCCGGGGCTGGCGGCTACTCAGCAGCCCTCCTCACCCCGTCTGGGGTTCAGCCCCTCCTCTGCCACCTCCCCTATCCACCCAGCCCATTCTCTCTCCT GTCCAACCTAACCCCTTTCCTGCGGGCTTTTCCCCGGTCCCTTGAGACCTCAGCCATGAGGAGTTGCTGTTTGTTTGACAAAGAAACCCAAGTGGGGGCA GAGGGCAGAGGCTGGAGGCAGGGCCTTGCCCAGAGATGCCTCCACCGCTGCCTAAGTGGCTGCTGACTGATGTTGAGGGAACAGACAGGAGAAATGCATC CATTCCTCAGGGACAGAGACACCTGCACCTCCCCCCACTGCAGGCCCCGCTTGTCCAGCGCCTAGTGGGGTCTCCCTCTCCTGCCTACTCACGATAAATA ATCGGCCCACAGCTCCCACCCCACCCCCTTCAGTGCCCACCAACATCCCATTGCCCTGGTTATATTCTCACGGGCAGTAGCTGTGGTGAGGTGGGTTTTC TTCCCATCACTGGAGCACCAGGCACGAACCCACCTGCTGAGAGACCCAAGGAGGAAAAACAGACAAAAACAGCCTCACAGAAGAATATGACAGCTGTCCC TGTCACCAAGCTCACAGTTCCTCGCCCTGGGTCTAAGGGGTTGGTTGAGGTGGAAGCCCTCCTTCCACGGATCCATGTAGCAGGACTGAATTGTCCCCAG TTTGCAGAAAAGCACCTGCCGACCTCGTCCTCCCCCTGCCAGTGCCTTACCTCCTGCCCAGGAGAGCCAGCCCTCCCTGTCCTCCTCGGATCACCGAGAG TAGCCGAGAGCCTGCTCCCCCACCCCCTCCCCAGGGGAGAGGGTCTGGAGAAGCAGTGAGCCGCATCTTCTCCATCTGGCAGGGTGGGATGGAGGAGAAG AATTTTCAGACCCCAGCGGCTGAGTCATGATCTCCCTGCCGCCTCAATGTGGTTGCAAGGCCGCTGTTCACCCACAGGGCTAAGAGCTAGCGCTGCCGCA CCCCAGAGTGTGGGAAGGGAGAGCGGGGCAGTCTCGGGTGGCTAGTCAGAGAGAGTGTTTGGGGGTTCCGTGATGTAGGGTAAGGTGCCTTCTTATTCTC ACTCCACCACCCAAAAGTCAAAAGGTGCCTGTGAGGCAGGGGCGGAGTGATACAACTTCAAGTGCATGCTCTCTGCAGCCAGCCCAGCCCAGCTGGTGGG AAGCGTCTGTCCGTTTACTCCAAGGTGGGGTCTTTGTGAGAGTGAGCTGTAGGTGTGCGGGACCGGTACAGAAAGGCGTTCTTCGAGGTGGATCACAGAG GCTTCTTCAGATCAGTGCTTGAGTTTGGGGAATGCGGCCGCATTCCCTGAGTCACCAGGAATGTTAAAGTCAGTGGGAACGTGACTGCCCCAACTCCTGG AAGCTGTGTCCTTGCACCTGCATCCGTAGTTCCCTGAAAACCCAGAGAGGAATCAGACTTCACACTGCAAGAGCCTTGGTGTCCACCTGGCCCCATGTCT CTCAGAATTCTTCAGGTGGAAAAACATCTGAAAGCCACGTTCCTTACTGCAGAATAGCATATATATCGCTTAATCTTAAATTTATTAGATATGAGTTGTT TTCAGACTCAGACTCCATTTGTATTATAGTCTAATATACAGGGTAGCAGGTACCACTGATTTGGAGATATTTATGGGGGGAGAACTTACATTGTGAAACT TCTGTACATTAATTATTATTGCTGTTGTTATTTTACAAGGGTCTAGGGAGAGACCCTTGTTTGATTTTAGCTGCAGAACGTATTGGTCCAGCTTGCTCTT CAGTGGGAGAAAACACTTGTAAGTTGCTAAACGAGTCAATCCCCTCATTCAGGAAAACTGACAGAGGAGGGCGTGACTCACCCAAGCATATATAACTAGC TAGAAGTGGGCCAGGACAGGCCCGGCGCGGTGGCTCACGCCTGTAATCCCAGCAGTTTGGGAGGTCGAGGTAGGTGGATCACCTGAGGTCGGGAGTTCGA GACCAACCTGACCAACATGGAGAAACCCTGTCTCTATTAAAAATACAAAAAAAAAAAAAAAAAAAATAGCCGGGCATGGTGGCGCAAGCCTGTAATCCCA GCTACTCAGGAGGCTGAGGCAGAAGAATTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGTGCCGTTACTCTCCAACCTGGACAACAAGAGCGA AACTCCGTCTTAGAAGTGGACCAGGACAGGACCAGATTTTGGAGTCATGGTCCGGTGTCCTTTTCACTACACCATGTTTGAGCTCAGACCCCCACTCTCA TTCCCCAGGTGGCTGACCCAGTCCCTGGGGGAAGCCCTGGATTTCAGAAAGAGCAAGTCTGGATCTGGGACCCTTTCCTTCCTTCCCTGGCTTGTAACTC CACCAACCCATCAGAAGGAGAAGGAAGGAGACTCACCTCTGCCTCAATGTGAATCAGACCCTACCCCACCACGATGTGGCCCTGGCCTGCTGGGCTCTCC ACCTCAGCCTTGGATAATGCTGTTGCCTCATCTATAACATGCATTTGTCTTTGTAATGTCACCACCTTCCCAGCTCTCCCTCTGGCCCTGCCTTCTTCGG GGAACTCCTGGAAATATCAGTTACTCAGCCCTGGGCCCCACCACCTAGGCCACTCCTCCAAAGGAAGTCTAGGAGCTGGGAGGAAAAGAAAAGAGGGGAA AATGAGTTTTTATGGGGCTGAACGGGGAGAAAAGGTCATCATCGATTCTACTTTAGAATGAGAGTGTGAAATAGACATTTGTAAATGTAAAACTTTTAAG GTATATCATTATAACTGAAGGAGAAGGTGCCCCAAAATGCAAGATTTTCCACAAGATTCCCAGAGACAGGAAAATCCTCTGGCTGGCTAACTGGAAGCAT GTAGGAGAATCCAAGCGAGGTCAACAGAGAAGGCAGGAATGTGTGGCAGATTTAGTGAAAGCTAGAGATATGGCAGCGAAAGGATGTAAACAGTGCCTGC TGAATGATTTCCAAAGAGAAAAAAAGTTTGCCAGAAGTTTGTCAAGTCAACCAATGTAGAAAGCTTTGCTTATGGTAATAAAAATGGCTCATACTTATAT AGCACTTACTTTGTTGCAAGTACTGCTGTAAATAAATGCTTTATGCAAACCAA

VDR.F2 (forward primer)
VDR.R2 (reverse primer)
Single exon skipping

Frame 0

LLVKRRQRSRVRRERGTACPPAGRTRSLWV*SV CETSQKSTPGLHLPAPCSFRDGGNGGQHFPA*PW RL*PERAPDLWGVWRPSHWLSLQCYDL*RLQRL LQAKHEAEGTIHLPLQRGLPHHQGQPTPLPGLP AQTLCGHRHDEGVHSDR*GSAEEAGDDPEAEGGG GLEGQSAAQAV*GAAAHHCHTAGRPP*DLRPHL LRLLPVPASSSCE*WWREPSFQAQLQTHSQLLW GLLLLLLRSLYHLFRHDGLVQLLQSGSE*RRFR* PFCDPRAVPALHAAPPG*PGQLQHPKGHWLC*D DTRIQRPHL*GPDRTAEVKCH*GHHVALQ*VLH HGRHVLDLWQPRLQVPRQ*RDQSRTQPGAD*APH QVPGGTEEAELA*GGACPAHGHLHRLPRSSWGA GRRAD*GHPGPPVQHTADVHPLPPPAPGQPPAL CQDDPEASRPAQPQ*GALQAVPLPLLPA*VQHEA NAPCARSVWQ*DLLTRTACGGAWVGLLLQGHVP GPGLAATQQPSSPRLGFSPSSATSPIHPAHSLS CPT*PLSCGLFPGPLRPQP*GVAVCLTKKPKWGQ RAEAGGRALPRDASTAA*VAAD*C*GNRQEKCI HSSGTETPAPPPTAGPACPAPSGVSLSCLLTIN NRPTAPTPPPSVPTNIPLPWLYSHGQ*LW*GGFS SHHWSTRHEPTC*ETQGGKTDKNSLTEEYDSCP CHQAHSSSPWV*GVG*GGSPPSTDPCSRTELSP VCRKAPADLVLPLPVPYLLPRRASPPCPPRITES SREPAPPPPPQGRGSGEAVSRIFSIWQGGMEEK NFQTPAAES*SPCRLNVVARPLFTHRAKS*RCR TPECGKGERGSLGWLVRESVWGFRDVG*GAFLFS LHHPKVKRCL*GRGGVIQLQVHALCSQPSPAGG KRLSVYSKVGSL*E*AVGVRDRYRKAFFEVDHR GFFRSVLEFGECGRIP*VTRNVKVSGNVTAPTPG SCVLAPASVVP*KPREESDFTLQEPWCPPGPMS LRILQVEKHLKATFLTAE*HIYRLILNLLDMSC FQTQTPFVL*SNIQGSRYH*FGDIYGGRTYIVKL LYINYYCCCYFTRV*GETLV*F*LQNVLVQLAL QWEKTLVSC*TSQSPHSGKLTEEGVTHPSIYN* LEVGQDRPGAVAHACNPSSLGGRGRWIT*GREFE TNLTNMEKPCLY*KYKKKKKKNSRAWWRKPVIP ATQEAEAEELNPGGGGCSELRSCRYSPTWTTRA KLRLRSGPGQDQILESWSGVLFTTPCLSSDPHSH SPGG*PSPWGKPWISERASLDLGPFPSFPGL*L HQPIRRRRKETHLCLNVNQTLPHHDVALACWAL HLSLG*CCCLIYNMHLSL*CHHLPSSPSGPAFFG ELLEISVTQPWAPPPRPLLQRKSRSWEEKKRGE NEFLWG*TGRKGHHRFYFRMRV*NRHL*M*NF* GISL*LKEKVPQNARFSTRFPETGKSSGWLTGSM *ENPSEVNREGRNVWQI**KLEIWQRKDVNSAC *MISKEKKSLPEVCQVNQCRKLCLW**KWLILI *HLLCCKYCCK*MLYANQ

Frame 1

CLSKGGSGAVCAGSAEQLVHPPAGPEAFGSEVS VRPHRRAPLGSTYLPPAPSGMEAMAASTSLPDP GDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGF FRRSMKRKALFTCPFNGDCRITKDNRRHCQACR LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE EALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTY SDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSD DPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKM IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPL IKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQ DAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLY AKMIQKLADLRSLNEEHSKQYRCLSFQPECSMK LTPLVLEVFGNEIS*LGQPVAVPGWGCSSRATCQ ARGWRLLSSPPHPVWGSAPPLPPPLSTQPILSP VQPNPFPAGFSPVP*DLSHEELLFV*QRNPSGG RGQRLEAGPCPEMPPPLPKWLLTDVEGTDRRNAS IPQGQRHLHLPPLQAPLVQRLVGSPSPAYSR*I IGPQLPPHPLQCPPTSHCPGYILTGSSCGEVGF LPITGAPGTNPPAERPKEEKQTKTASQKNMTAVP VTKLTVPRPGSKGLVEVEALLPRIHVAGLNCPQ FAEKHLPTSSSPCQCLTSCPGEPALPVLLGSPR VAESLLPHPLPRGEGLEKQ*AASSPSGRVGWRRR IFRPQRLSHDLPAASMWLQGRCSPTGLRASAAA PQSVGRESGAVSGG*SERVFGGSVM*GKVPSYS HSTTQKSKGACEAGAE*YNFKCMLSAASPAQLVG SVCPFTPRWGLCESEL*VCGTGTERRSSRWITE ASSDQCLSLGNAAAFPESPGMLKSVGT*LPQLL EAVSLHLHP*FPENPERNQTSHCKSLGVHLAPCL SEFFRWKNI*KPRSLLQNSIYIA*S*IY*I*VV FRLRLHLYYSLIYRVAGTTDLEIFMGGELTL*N FCTLIIIAVVILQGSRERPLFDFSCRTYWSSLLF SGRKHL*VAKRVNPLIQEN*QRRA*LTQAYITS *KWARTGPARWLTPVIPAVWEVEVGGSPEVGSS RPT*PTWRNPVSIKNTKKKKKKIAGHGGASL*SQ LLRRLRQKN*TQEVEVAVS*DRAVTLQPGQQER NSVLEVDQDRTRFWSHGPVSFSLHHV*AQTPTL IPQVADPVPGGSPGFQKEQVWIWDPFLPSLACNS TNPSEGEGRRLTSASM*IRPYPTTMWPWPAGLS TSALDNAVASSITCICLCNVTTFPALPLALPSS GNSWKYQLLSPGPHHLGHSSKGSLGAGRKRKEGK MSFYGAERGEKVIIDSTLE*ECEIDICKCKTFK VYHYN*RRRCPKMQDFPQDSQRQENPLAG*LEA CRRIQARSTEKAGMCGRFSES*RYGSERM*TVPA E*FPKRKKVCQKFVKSTNVESFAYGNKNGSYLY STYFVASTAVNKCFMQT

Frame 2

ACQKAAAEPCAPGARNSLSTRRPDQKPLGLKCL *DLTEEHPWAPLTCPLLLQGWRQWRPALPCLTL ETLTGTCPGSVGCVETEPLAFTSML*PVKAAKA SSGEA*SGRHYSPAPSTGTAASPRTTDATARPAG SNAVWTSA**RSSF*QMRKCRGSGR*S*SGRRR RP*RTVCGPSCLRSSSASLPYCWTPTIRPTTPP TPTSASSGLQFV*MMVEGAILPGPTPDTLPASLG TPPPPAQITVSPLQT*WTRPASPIWI*VKKIQM TLL*P*SCPSSPCCPTWLTWSVTASKRSLALLR *YQDSETSPLRTRSYC*SQVPLRSSCCAPMSPSP WTTCPGPVATKTTSTASVT*PKPDTAWS*LSPS SSSRWD*RS*TCMRRSMSCSWPSASSPQIVLGC RTPR*LRPSRTACPTHCRRTSAAATRPRAATCSM PR*SRS*PTCAASMRSTPSSTAASPSSLSAA*S *RPLCSKCLAMRSPD*DSLWRCLGGAAPPGPRA RPGAGGYSAALLTPSGVQPLLCHLPYPPSPFSLL SNLTPFLRAFPRSLETSAMRSCCLFDKETQVGA EGRGWRQGLAQRCLHRCLSGC*LMLREQTGEMH PFLRDRDTCTSPHCRPRLSSA*WGLPLLPTHDK* SAHSSHPTPFSAHQHPIALVIFSRAVAVVRWVF FPSLEHQARTHLLRDPRRKNRQKQPHRRI*QLS LSPSSQFLALGLRGWLRWKPSFHGSM*QD*IVPS LQKSTCRPRPPPASALPPAQESQPSLSSSDHRE *PRACSPTPSPGERVWRSSEPHLLHLAGWDGGE EFSDPSG*VMISLPPQCGCKAAVHPQG*ELALPH PRVWEGRAGQSRVASQRECLGVP*CRVRCLLIL TPPPKSQKVPVRQGRSDTTSSACSLQPAQPSWW EASVRLLQGGVFVRVSCRCAGPVQKGVLRGGSQR LLQISA*VWGMRPHSLSHQEC*SQWERDCPNSW KLCPCTCIRSSLKTQRGIRLHTARALVSTWPHV SQNSSGGKTSESHVPYCRIAYISLNLKFIRYELF SDSDSICIIV*YTG*QVPLIWRYLWGENLHCET SVH*LLLLLLFYKGLGRDPCLILAAERIGPACS SVGENTCKLLNESIPSFRKTDRGGRDSPKHI*LA RSGPGQARRGGSRL*SQQFGRSR*VDHLRSGVR DQPDQHGETLSLLKIQKKKKKK*PGMVAQACNP SYSGG*GRRIEPRRWRLQ*AEIVPLLSNLDNKSE TPS*KWTRTGPDFGVMVRCPFHYTMFELRPPLS FPRWLTQSLGEALDFRKSKSGSGTLSFLPWLVT PPTHQKEKEGDSPLPQCESDPTPPRCGPGLLGSP PQPWIMLLPHL*HAFVFVMSPPSQLSLWPCLLR GTPGNISYSALGPTT*ATPPKEV*ELGGKEKRG K*VFMGLNGEKRSSSILL*NESVK*TFVNVKLLR YIIITEGEGAPKCKIFHKIPRDRKILWLANWKH VGESKRGQQRRQECVADLVKARDMAAKGCKQCL LNDFQREKKFARSLSSQPM*KALLMVIKMAHTYI ALTLLQVLL*INALCKP

Sequence VDR.bAug05

CTGCTTGTCAAAAGGCGGCAGCGGAGCCGTGTGCGCCGGGAGCGCGGAACAGCTTGTCCACCCGCCGGCCGGACCAGGGCTCCTGAACCTAGCCCAGCTG GACGGAGAAATGGACTCTAGCCTCCTCTGATAGCCTCATGCCAGGCCCCGTGCACATTGCTTTGCTTGCCTCCCTCAATCCTCATAGCTTCTCTTTGGGA AGCCTTTGGGTCTGAAGTGTCTGTGAGACCTCACAGAAGAGCACCCCTGGGCTCCACTTACCTGCCCCCTGCTCCTTCAGGGATGGAGGCAATGGCGGCC AGCACTTCCCTGCCTGACCCTGGAGACTTTGACCGGAACGTGCCCCGGATCTGTGGGGTGTGTGGAGACCGAGCCACTGGCTTTCACTTCAATGCTATGA CCTGTGAAGGCTGCAAAGGCTTCTTCAGGCGAAGCATGAAGCGGAAGGCACTATTCACCTGCCCCTTCAACGGGGACTGCCGCATCACCAAGGACAACCG ACGCCACTGCCAGGCCTGCCGGCTCAAACGCTGTGTGGACATCGGCATGATGAAGGAGTTCATTCTGACAGATGAGGAAGTGCAGAGGAAGCGGGAGATG ATCCTGAAGCGGAAGGAGGAGGAGGCCTTGAAGGACAGTCTGCGGCCCAAGCTGTCTGAGGAGCAGCAGCGCATCATTGCCATACTGCTGGACGCCCACC ATAAGACCTACGACCCCACCTACTCCGACTTCTGCCAGTTCCGGCCTCCAGTTCGTGTGAATGATGGTGGAGGGAGCCATCCTTCCAGGCCCAACTCCAG ACACACTCCCAGCTTCTCTGGGGACTCCTCCTCCTCCTGCTCAGATCACTGTATCACCTCTTCAGACATGATGGACTCGTCCAGCTTCTCCAATCTGGAT CTGAGTGAAGAAGATTCAGATGACCCTTCTGTGACCCTAGAGCTGTCCCAGCTCTCCATGCTGCCCCACCTGGCTGACCTGGTCAGTTACAGCATCCAAA AGGTCATTGGCTTTGCTAAGATGATACCAGGATTCAGAGACCTCACCTCTGAGGACCAGATCGTACTGCTGAAGTCAAGTGCCATTGAGGTCATCATGTT GCGCTCCAATGAGTCCTTCACCATGGACGACATGTCCTGGACCTGTGGCAACCAAGACTACAAGTACCGCGTCAGTGACGTGACCAAAGCCGGACACAGC CTGGAGCTGATTGAGCCCCTCATCAAGTTCCAGGTGGGACTGAAGAAGCTGAACTTGCATGAGGAGGAGCATGTCCTGCTCATGGCCATCTGCATCGTCT CCCCAGATCGTCCTGGGGTGCAGGACGCCGCGCTGATTGAGGCCATCCAGGACCGCCTGTCCAACACACTGCAGACGTACATCCGCTGCCGCCACCCGCC CCCGGGCAGCCACCTGCTCTATGCCAAGATGATCCAGAAGCTAGCCGACCTGCGCAGCCTCAATGAGGAGCACTCCAAGCAGTACCGCTGCCTCTCCTTC CAGCCTGAGTGCAGCATGAAGCTAACGCCCCTTGTGCTCGAAGTGTTTGGCAATGAGATCTCCTGACTAGGACAGCCTGTGGCGGTGCCTGGGTGGGGCT GCTCCTCCAGGGCCACGTGCCAGGCCCGGGGCTGGCGGCTACTCAGCAGCCCTCCTCACCCCGTCTGGGGTTCAGCCCCTCCTCTGCCACCTCCCCTATC CACCCAGCCCATTCTCTCTCCTGTCCAACCTAACCCCTTTCCTGCGGGCTTTTCCCCGGTCCCTTGAGACCTCAGCCATGAGGAGTTGCTGTTTGTTTGA CAAAGAAACCCAAGTGGGGGCAGAGGGCAGAGGCTGGAGGCAGGGCCTTGCCCAGAGATGCCTCCACCGCTGCCTAAGTGGCTGCTGACTGATGTTGAGG GAACAGACAGGAGAAATGCATCCATTCCTCAGGGACAGAGACACCTGCACCTCCCCCCACTGCAGGCCCCGCTTGTCCAGCGCCTAGTGGGGTCTCCCTC TCCTGCCTACTCACGATAAATAATCGGCCCACAGCTCCCACCCCACCCCCTTCAGTGCCCACCAACATCCCATTGCCCTGGTTATATTCTCACGGGCAGT AGCTGTGGTGAGGTGGGTTTTCTTCCCATCACTGGAGCACCAGGCACGAACCCACCTGCTGAGAGACCCAAGGAGGAAAAACAGACAAAAACAGCCTCAC AGAAGAATATGACAGCTGTCCCTGTCACCAAGCTCACAGTTCCTCGCCCTGGGTCTAAGGGGTTGGTTGAGGTGGAAGCCCTCCTTCCACGGATCCATGT AGCAGGACTGAATTGTCCCCAGTTTGCAGAAAAGCACCTGCCGACCTCGTCCTCCCCCTGCCAGTGCCTTACCTCCTGCCCAGGAGAGCCAGCCCTCCCT GTCCTCCTCGGATCACCGAGAGTAGCCGAGAGCCTGCTCCCCCACCCCCTCCCCAGGGGAGAGGGTCTGGAGAAGCAGTGAGCCGCATCTTCTCCATCTG GCAGGGTGGGATGGAGGAGAAGAATTTTCAGACCCCAGCGGCTGAGTCATGATCTCCCTGCCGCCTCAATGTGGTTGCAAGGCCGCTGTTCACCCACAGG GCTAAGAGCTAGCGCTGCCGCACCCCAGAGTGTGGGAAGGGAGAGCGGGGCAGTCTCGGGTGGCTAGTCAGAGAGAGTGTTTGGGGGTTCCGTGATGTAG GGTAAGGTGCCTTCTTATTCTCACTCCACCACCCAAAAGTCAAAAGGTGCCTGTGAGGCAGGGGCGGAGTGATACAACTTCAAGTGCATGCTCTCTGCAG CCAGCCCAGCCCAGCTGGTGGGAAGCGTCTGTCCGTTTACTCCAAGGTGGGGTCTTTGTGAGAGTGAGCTGTAGGTGTGCGGGACCGGTACAGAAAGGCG TTCTTCGAGGTGGATCACAGAGGCTTCTTCAGATCAGTGCTTGAGTTTGGGGAATGCGGCCGCATTCCCTGAGTCACCAGGAATGTTAAAGTCAGTGGGA ACGTGACTGCCCCAACTCCTGGAAGCTGTGTCCTTGCACCTGCATCCGTAGTTCCCTGAAAACCCAGAGAGGAATCAGACTTCACACTGCAAGAGCCTTG GTGTCCACCTGGCCCCATGTCTCTCAGAATTCTTCAGGTGGAAAAACATCTGAAAGCCACGTTCCTTACTGCAGAATAGCATATATATCGCTTAATCTTA AATTTATTAGATATGAGTTGTTTTCAGACTCAGACTCCATTTGTATTATAGTCTAATATACAGGGTAGCAGGTACCACTGATTTGGAGATATTTATGGGG GGAGAACTTACATTGTGAAACTTCTGTACATTAATTATTATTGCTGTTGTTATTTTACAAGGGTCTAGGGAGAGACCCTTGTTTGATTTTAGCTGCAGAA CGTATTGGTCCAGCTTGCTCTTCAGTGGGAGAAAACACTTGTAAGTTGCTAAACGAGTCAATCCCCTCATTCAGGAAAACTGACAGAGGAGGGCGTGACT CACCCAAGCATATATAACTAGCTAGAAGTGGGCCAGGACAGGCCCGGCGCGGTGGCTCACGCCTGTAATCCCAGCAGTTTGGGAGGTCGAGGTAGGTGGA TCACCTGAGGTCGGGAGTTCGAGACCAACCTGACCAACATGGAGAAACCCTGTCTCTATTAAAAATACAAAAAAAAAAAAAAAAAAAATAGCCGGGCATG GTGGCGCAAGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGTGCCGTTACTCT CCAACCTGGACAACAAGAGCGAAACTCCGTCTTAGAAGTGGACCAGGACAGGACCAGATTTTGGAGTCATGGTCCGGTGTCCTTTTCACTACACCATGTT TGAGCTCAGACCCCCACTCTCATTCCCCAGGTGGCTGACCCAGTCCCTGGGGGAAGCCCTGGATTTCAGAAAGAGCAAGTCTGGATCTGGGACCCTTTCC TTCCTTCCCTGGCTTGTAACTCCACCAACCCATCAGAAGGAGAAGGAAGGAGACTCACCTCTGCCTCAATGTGAATCAGACCCTACCCCACCACGATGTG GCCCTGGCCTGCTGGGCTCTCCACCTCAGCCTTGGATAATGCTGTTGCCTCATCTATAACATGCATTTGTCTTTGTAATGTCACCACCTTCCCAGCTCTC CCTCTGGCCCTGCCTTCTTCGGGGAACTCCTGGAAATATCAGTTACTCAGCCCTGGGCCCCACCACCTAGGCCACTCCTCCAAAGGAAGTCTAGGAGCTG GGAGGAAAAGAAAAGAGGGGAAAATGAGTTTTTATGGGGCTGAACGGGGAGAAAAGGTCATCATCGATTCTACTTTAGAATGAGAGTGTGAAATAGACAT TTGTAAATGTAAAACTTTTAAGGTATATCATTATAACTGAAGGAGAAGGTGCCCCAAAATGCAAGATTTTCCACAAGATTCCCAGAGACAGGAAAATCCT CTGGCTGGCTAACTGGAAGCATGTAGGAGAATCCAAGCGAGGTCAACAGAGAAGGCAGGAATGTGTGGCAGATTTAGTGAAAGCTAGAGATATGGCAGCG AAAGGATGTAAACAGTGCCTGCTGAATGATTTCCAAAGAGAAAAAAAGTTTGCCAGAAGTTTGTCAAGTCAACCAATGTAGAAAGCTTTGCTTATGGTAA TAAAAATGGCTCATACTTATATAGCACTTACTTTGTTGCAAGTACTGCTGTAAATAAATGCTTTATGCAAACCAA

VDR.F2 (forward primer)
VDR.R2 (reverse primer)
Single exon skipping

Frame 0

LLVKRRQRSRVRRERGTACPPAGRTRAPEPSPA GRRNGL*PPLIASCQAPCTLLCLPPSILIASLWE AFGSEVSVRPHRRAPLGSTYLPPAPSGMEAMAA STSLPDPGDFDRNVPRICGVCGDRATGFHFNAM TCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNR RHCQACRLKRCVDIGMMKEFILTDEEVQRKREM ILKRKEEEALKDSLRPKLSEEQQRIIAILLDAH HKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSR HTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLD LSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQ KVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIML RSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHS LELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV SPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPP PGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSF QPECSMKLTPLVLEVFGNEIS*LGQPVAVPGWG CSSRATCQARGWRLLSSPPHPVWGSAPPLPPPLS TQPILSPVQPNPFPAGFSPVP*DLSHEELLFV* QRNPSGGRGQRLEAGPCPEMPPPLPKWLLTDVE GTDRRNASIPQGQRHLHLPPLQAPLVQRLVGSPS PAYSR*IIGPQLPPHPLQCPPTSHCPGYILTGS SCGEVGFLPITGAPGTNPPAERPKEEKQTKTAS QKNMTAVPVTKLTVPRPGSKGLVEVEALLPRIHV AGLNCPQFAEKHLPTSSSPCQCLTSCPGEPALP VLLGSPRVAESLLPHPLPRGEGLEKQ*AASSPS GRVGWRRRIFRPQRLSHDLPAASMWLQGRCSPTG LRASAAAPQSVGRESGAVSGG*SERVFGGSVM* GKVPSYSHSTTQKSKGACEAGAE*YNFKCMLSA ASPAQLVGSVCPFTPRWGLCESEL*VCGTGTERR SSRWITEASSDQCLSLGNAAAFPESPGMLKSVG T*LPQLLEAVSLHLHP*FPENPERNQTSHCKSL GVHLAPCLSEFFRWKNI*KPRSLLQNSIYIA*S* IY*I*VVFRLRLHLYYSLIYRVAGTTDLEIFMG GELTL*NFCTLIIIAVVILQGSRERPLFDFSCR TYWSSLLFSGRKHL*VAKRVNPLIQEN*QRRA*L TQAYITS*KWARTGPARWLTPVIPAVWEVEVGG SPEVGSSRPT*PTWRNPVSIKNTKKKKKKIAGH GGASL*SQLLRRLRQKN*TQEVEVAVS*DRAVTL QPGQQERNSVLEVDQDRTRFWSHGPVSFSLHHV *AQTPTLIPQVADPVPGGSPGFQKEQVWIWDPF LPSLACNSTNPSEGEGRRLTSASM*IRPYPTTMW PWPAGLSTSALDNAVASSITCICLCNVTTFPAL PLALPSSGNSWKYQLLSPGPHHLGHSSKGSLGA GRKRKEGKMSFYGAERGEKVIIDSTLE*ECEIDI CKCKTFKVYHYN*RRRCPKMQDFPQDSQRQENP LAG*LEACRRIQARSTEKAGMCGRFSES*RYGS ERM*TVPAE*FPKRKKVCQKFVKSTNVESFAYGN KNGSYLYSTYFVASTAVNKCFMQT

Frame 1

CLSKGGSGAVCAGSAEQLVHPPAGPGLLNLAQL DGEMDSSLL**PHARPRAHCFACLPQSS*LLFG KPLGLKCL*DLTEEHPWAPLTCPLLLQGWRQWRP ALPCLTLETLTGTCPGSVGCVETEPLAFTSML* PVKAAKASSGEA*SGRHYSPAPSTGTAASPRTT DATARPAGSNAVWTSA**RSSF*QMRKCRGSGR* S*SGRRRRP*RTVCGPSCLRSSSASLPYCWTPT IRPTTPPTPTSASSGLQFV*MMVEGAILPGPTP DTLPASLGTPPPPAQITVSPLQT*WTRPASPIWI *VKKIQMTLL*P*SCPSSPCCPTWLTWSVTASK RSLALLR*YQDSETSPLRTRSYC*SQVPLRSSC CAPMSPSPWTTCPGPVATKTTSTASVT*PKPDTA WS*LSPSSSSRWD*RS*TCMRRSMSCSWPSASS PQIVLGCRTPR*LRPSRTACPTHCRRTSAAATR PRAATCSMPR*SRS*PTCAASMRSTPSSTAASPS SLSAA*S*RPLCSKCLAMRSPD*DSLWRCLGGA APPGPRARPGAGGYSAALLTPSGVQPLLCHLPY PPSPFSLLSNLTPFLRAFPRSLETSAMRSCCLFD KETQVGAEGRGWRQGLAQRCLHRCLSGC*LMLR EQTGEMHPFLRDRDTCTSPHCRPRLSSA*WGLP LLPTHDK*SAHSSHPTPFSAHQHPIALVIFSRAV AVVRWVFFPSLEHQARTHLLRDPRRKNRQKQPH RRI*QLSLSPSSQFLALGLRGWLRWKPSFHGSM *QD*IVPSLQKSTCRPRPPPASALPPAQESQPSL SSSDHRE*PRACSPTPSPGERVWRSSEPHLLHL AGWDGGEEFSDPSG*VMISLPPQCGCKAAVHPQ G*ELALPHPRVWEGRAGQSRVASQRECLGVP*CR VRCLLILTPPPKSQKVPVRQGRSDTTSSACSLQ PAQPSWWEASVRLLQGGVFVRVSCRCAGPVQKG VLRGGSQRLLQISA*VWGMRPHSLSHQEC*SQWE RDCPNSWKLCPCTCIRSSLKTQRGIRLHTARAL VSTWPHVSQNSSGGKTSESHVPYCRIAYISLNL KFIRYELFSDSDSICIIV*YTG*QVPLIWRYLWG ENLHCETSVH*LLLLLLFYKGLGRDPCLILAAE RIGPACSSVGENTCKLLNESIPSFRKTDRGGRD SPKHI*LARSGPGQARRGGSRL*SQQFGRSR*VD HLRSGVRDQPDQHGETLSLLKIQKKKKKK*PGM VAQACNPSYSGG*GRRIEPRRWRLQ*AEIVPLL SNLDNKSETPS*KWTRTGPDFGVMVRCPFHYTMF ELRPPLSFPRWLTQSLGEALDFRKSKSGSGTLS FLPWLVTPPTHQKEKEGDSPLPQCESDPTPPRC GPGLLGSPPQPWIMLLPHL*HAFVFVMSPPSQLS LWPCLLRGTPGNISYSALGPTT*ATPPKEV*EL GGKEKRGK*VFMGLNGEKRSSSILL*NESVK*T FVNVKLLRYIIITEGEGAPKCKIFHKIPRDRKIL WLANWKHVGESKRGQQRRQECVADLVKARDMAA KGCKQCLLNDFQREKKFARSLSSQPM*KALLMV IKMAHTYIALTLLQVLL*INALCKP

Frame 2

ACQKAAAEPCAPGARNSLSTRRPDQGS*T*PSW TEKWTLASSDSLMPGPVHIALLASLNPHSFSLG SLWV*SVCETSQKSTPGLHLPAPCSFRDGGNGG QHFPA*PWRL*PERAPDLWGVWRPSHWLSLQCYD L*RLQRLLQAKHEAEGTIHLPLQRGLPHHQGQP TPLPGLPAQTLCGHRHDEGVHSDR*GSAEEAGD DPEAEGGGGLEGQSAAQAV*GAAAHHCHTAGRPP *DLRPHLLRLLPVPASSSCE*WWREPSFQAQLQ THSQLLWGLLLLLLRSLYHLFRHDGLVQLLQSG SE*RRFR*PFCDPRAVPALHAAPPG*PGQLQHPK GHWLC*DDTRIQRPHL*GPDRTAEVKCH*GHHV ALQ*VLHHGRHVLDLWQPRLQVPRQ*RDQSRTQ PGAD*APHQVPGGTEEAELA*GGACPAHGHLHRL PRSSWGAGRRAD*GHPGPPVQHTADVHPLPPPA PGQPPALCQDDPEASRPAQPQ*GALQAVPLPLL PA*VQHEANAPCARSVWQ*DLLTRTACGGAWVGL LLQGHVPGPGLAATQQPSSPRLGFSPSSATSPI HPAHSLSCPT*PLSCGLFPGPLRPQP*GVAVCL TKKPKWGQRAEAGGRALPRDASTAA*VAAD*C*G NRQEKCIHSSGTETPAPPPTAGPACPAPSGVSL SCLLTINNRPTAPTPPPSVPTNIPLPWLYSHGQ *LW*GGFSSHHWSTRHEPTC*ETQGGKTDKNSLT EEYDSCPCHQAHSSSPWV*GVG*GGSPPSTDPC SRTELSPVCRKAPADLVLPLPVPYLLPRRASPP CPPRITESSREPAPPPPPQGRGSGEAVSRIFSIW QGGMEEKNFQTPAAES*SPCRLNVVARPLFTHR AKS*RCRTPECGKGERGSLGWLVRESVWGFRDV G*GAFLFSLHHPKVKRCL*GRGGVIQLQVHALCS QPSPAGGKRLSVYSKVGSL*E*AVGVRDRYRKA FFEVDHRGFFRSVLEFGECGRIP*VTRNVKVSG NVTAPTPGSCVLAPASVVP*KPREESDFTLQEPW CPPGPMSLRILQVEKHLKATFLTAE*HIYRLIL NLLDMSCFQTQTPFVL*SNIQGSRYH*FGDIYG GRTYIVKLLYINYYCCCYFTRV*GETLV*F*LQN VLVQLALQWEKTLVSC*TSQSPHSGKLTEEGVT HPSIYN*LEVGQDRPGAVAHACNPSSLGGRGRW IT*GREFETNLTNMEKPCLY*KYKKKKKKNSRAW WRKPVIPATQEAEAEELNPGGGGCSELRSCRYS PTWTTRAKLRLRSGPGQDQILESWSGVLFTTPC LSSDPHSHSPGG*PSPWGKPWISERASLDLGPFP SFPGL*LHQPIRRRRKETHLCLNVNQTLPHHDV ALACWALHLSLG*CCCLIYNMHLSL*CHHLPSS PSGPAFFGELLEISVTQPWAPPPRPLLQRKSRSW EEKKRGENEFLWG*TGRKGHHRFYFRMRV*NRH L*M*NF*GISL*LKEKVPQNARFSTRFPETGKS SGWLTGSM*ENPSEVNREGRNVWQI**KLEIWQR KDVNSAC*MISKEKKSLPEVCQVNQCRKLCLW* *KWLILI*HLLCCKYCCK*MLYANQ