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Sequences

Sequence PTPRB.bAug05

GAAGCATGAACAGTTGCTAAGTGGAAAATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGAAGGGTTTCAGATTGTCC ATGTCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTGGGCTCATGCAACAGGACCATCCAGAACCAGCAGTGGATGTGGACTGAGGATGA AAAGCTCCTTCATGTTAAATCTGCACTGTGCTTGGCCATCTCCAACTCTTCCCGCGGCCCCTCCCGCTCAGCCATCTTGGACCGCTGTTCCCAGGCACCC CGATGGACCTGCTATGATCAGGAAGGCTTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGCTCCAGAGTAGTGGTCAAGAAGGCCAGGA AATACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAGGGAAAACTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTC GGTGAGGAGCACTAGAAACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGCCTGGTATTCCTTATTAGGAATACCACAGAGGCC TTCATCAGAAATGCTGCAGAAAACTACAGCCAAAACAGCAGCGAGAGGCAGCATCCCAATCTGCACATGACTGGAATTACAGACACATCATGGGTTTTGT CGACTACTCAGCCCTTCTCCAGCACCACTGAAGAGACTGGACTGGCGGAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTC TGTGTCTATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACCTTTCGGATA GACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGC AAACAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCAC CTCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTTCATGGAATGAATACACTTTTTTCAATCTC ACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGA AAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGG GATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAG GCTGCAGGGCTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGACCTCTCTAA AAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGAT TACTGAAACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGC AGAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGAGACTGGGAGC AGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACC GGGAAGACAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTT CGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCT TACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGG AGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTGCATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACT AACTGGACCCAGGCACAAGGAGACGTAGAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCA GATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAG AACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCAGCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCAC TATGAAGTCACCATTAAAAACAAAAACAACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGGT TGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTTAAGGATCTAACATTGCG CAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCAGGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTT CCTCCTTTTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCTTGTCTTGACGATTAGCGGGGATG TACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTG GACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCAC ACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGCGGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTC CAGCATCTGTCCAAGGAGTAATTGCAGACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTGGCAGAAAGATATGATAT CCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCAGAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATAC AAGATACAGATCCTAACTGTCAGTGGAGGCCTCTTTAGCAAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAG AGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCAGATGGGAATCTCCAGGA GAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTG TCTAATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGACAGACAGCCTTTGGTTCAACTGGA GTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCG GTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCTCCA AGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACGTGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGC TGCAGTGGTTGCCCAGAGATGCACTTACTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATCCTA TCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCAATTTTTGGATCTGTGAGGACAAAGCCTGACAAGATACAAAACCTG CATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGTTCTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATGGACACCC AAGAAGTTGAGTTTTCCAGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTGGTGTCCATCAAAGTGCA GTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATCACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGAT GTGCTAATTAGCAAGTCTTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTGGTGGTGAGAGAGG CTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCTCCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGGGTGTATCAGACTAATTA TTTTGCCAGCAAATGTGCCGAAAATCCTAACAGCAACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGATCCC ACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGAGCTTTTACACAGCTCTTTGATGAGGACCTGAAGGAAT TCACAAAGCCACTCTATTCAGACACATTTTTTTCTTTACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTGGTCTGTT TTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGG GATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGC TACAGGCTGACTCCAACTACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAG AGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGC TACATCCCTGGCAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACG TTCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTATGGGGACCT CATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGC CACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGTCAGGGACTACATCAACAGAAGCC CGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGA CTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGA GATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATT CAAGGCATTGAGAATGTACCTGAAGAGCTCCTGGATAAAAATTATTCACTGTGTGATTTGTTTTTAAAAACTTGCTTCATGCCCTACAGAGGTGCCAGCT ATTTCTGTTGATACTATGTATAATTTATTAATCTGGAGAATGTTTAAAATTTTATATAATTTAAAGGTAACAGATATTATTGTACATAGTTGTATTTTGT AGTTTCTTCTGTAAATATGTATTTTTCATAATGTTTAATATTAAGCTTTATATAATACTATTTTTCCACACTAAAGTGTTCATGACTTGTTCTACATAAA ACTAATTCAACCTGTATGACAGGACTACTGGTAAAATGCATATGGAGGTGGTGGCAGAGACAATCCTTCAGGCCATGTTTTCTACCTGTTTTGATATTCA CTGGACAGGAAAAAGGGCAGGGCTAGAGAGAGCAAATACTATGGCTAGATTTGCTGCATTGCTGTCCCATGAATCTCGAGAGCCAACAGACATGTCCTAA CTTGCTATTAGGACAAATGTGACAGTCAAAAAAAGGATTAGAGGGAGGGAGAAAAAAGAATTAAGCAGTACCAAAGCTGAACTAGATGCTTGTGTCTGAA CTAGTTGCTCTCTCTCTCCTTTCTCCTTCCAGGGATTCAAGCCAAAGTGGTCAGCTCAGGGATCATGTAACTTGCAGTGCAAGCCCAGGATGGTAGGATG CAGGGTTGAGGGTTCTGATAGAGAATGATTCCAAACAGAAGTGATGAATTCCTTTTGTTAATAAGATGCCAGCTATACCCAGACTGGAAACATAACATGC AAAGCACTATCTACAGTGATTAGAGATCCTTTCATTGCATTCATGGTGTGGAGTGTGAACATCCACACCCATACTGTAATGTATTTATACACACTAGTTT CTGTCTCATTTTCAGTGGTCTCCATTCCTAGAAAAGTCACAATTATCCATTCCTACTTGATTTCCCATTAAAAGAATATTATGGTAGCAGATTGTGCCCC TCATTAAAAGGCTTAATGCCAACATTTTCATAGAAATGACTACAAACATCATATATAGTAAATTTAAAAACAATAGCAAAAACAAAAACAGTGGTCTTCA GTAAAATTTTCAAAACTTCTTTTAGTAAATCAATGAAGTCAAAATGTCAAGTAATCACCCAAAGTTGCATTTAATAACAAAAGGCACTACATACTGTACC AAGTTTATCTTCAATATTTGTGCCTTACTTACTTTGACTATAACAAATTCCAATGAGTCAGAAAGTATTTCCTTCATCAAGGTCCAGTTCCGACAGCATT CCTGGGAAAAATTTGAAAGGAGTTTGTACGGAATCTTCATAGATACCTGAGAAGATGAGCTGGAGATGTTTGCCTTTTTCACACTACAAATTTTTCTGTA ATAAACTTGGGAATTAGAGGTCAAGTTTGTTGATGGCATAGCTTCCTTTGCATAAAGAGTATATTTCTTTTCAAAGTATATATTTTTGTAACCTACCATA AAGTCCGTAAGTGAATACAACGAATGTAATTGACATAATAATTGAAAATCATTGACTATACCTAAAATAGTTCTTTATAATTAAATAACTCTACACCCAA TCTGGAAATTTTTCCAAGGTTATTTGAAGTTTACAAAAATGTGAAGCATAATCATAAGCTTCAAAGATTCACAGTTTCATTGTGCTCAATGCTCTTGTGA AATGACAGTCTTAAGCTCTGATTCTGTATCAAGGAACTAAGTGAATCTTCTGGAAATGAAAAGGAACAACATATGTGTAAGTGCAGTAGATGTACCACCA GCGAGAAAATAGAGGTCAGAGATCTACAACGTGTGGCATCCATTAGAAATCACCTTTCCTACATTGAAAAGAAAAAAGAGAAAAAGCAGAATTTTACACT AATGTTGCTTGATGCAAAGCACATTAATGCTTGGAAGGATACATTCATTTTCGACTTTTCATTCACTCAGAAAACTTCTAGTAAGTATCTGCAACCTGCT AGGCACTGTTCCAGAATCTACACATTTCTACTCACATAAAGAGAATCCTCATAAAGTTAGGATTGTTGTTACTACCTTCAATTGAGCTTAAAAGACAGCC TCATCAAGGGAATGGGATAACTGAGCCAGTCTAGGACAGTGGTCACCTTCCACAGGCCACACACTGGAAAGTGCTAATGCTACTTTAATAGCAAACCTCT GGATCTAGGAGAGAGAGCAATTAATTGCACAAACCAGGAGTTAAAACCATAAAAAAAACCTATGCATCTGTAATAGTAAATAACACTCACGTACTCTGGC AACATCTAGGGTAGTATCAGAATTATGTAAATGGACATGACAGGGAAAAATCGTAGGTTTTTTTAGTCTAATCCAACCCAGGAAATGTTTATTCCTACCC TACACCTAATTTTAAACCTTCTTAGCAACAAATATTTCACTATTCGCTCCTACTCCTGGGAAGACTAAATATATAATTGACTTATTTATTAAATTTAGGA GAAAAAAAAAGTTTTCCTTGACATTCAGCTCTATTGGATTTATTTCCATTTAATTGCATCATGTGTTATGTCTTGGTAAACACTCCATTTCCTGTCTTGG TGGGCATCCTGTCTGTGTACCTGTGCAGTACACTTTAATCATCAAGACTTCAAAGTGCTTTTGAGCTATCAAATCTTGGGAGAGTCCCATCTAGCATCTT AATAATTATTTTTCCAAGTTCGTTATAATTAACTCCTTTAACCTCATCTCATTAAATCAATTTTGTATTGTCATTCTGTTGTTCTCTGGAAAGCAGCCAA TTGTTCAGCTCTTGAATCAGAATTTTCAAAGACTCACCTCTCTTACCTGGGCTTGCACATATTTGTCCTAAGTAATTCTCTATCCCTTAAACCTCTGAGT CCCTCTGTTTTATTACTTGCCCCACTCCTCCTACTTGAATATGTTTGTTTTCCCAGTTGAATGTGATTTTTATCTACTGTTCATATTATCTTTTATACCC ATGAGTATAATTTCATAGTCCTTTCAGGTTCCACATCATCAAAGAGATGACCATAATTTCACTTTTTTTTGAAATGAAGTCTTGCTCTGTTGCCCAGGCT GGAGTGCAGTGGCACAATCTCAGCTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCTGCCTTAGCCTCCCAAGTAGCTGGAATTACAGGTGCCTGC CACCATGTCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCGTGACCTTAGGTGATCCACCCACCT CAACCTCCCAAAGTGCTAGGATTACAAGAGTGAGCCACCGCACCTGGCCAATTCACTTTTAAATACTAAAAGGCACACAGCACACAGACATTTTCGGGGC AGTTTTCTTTGGGAGGGTCTTTGATAAATTTTGTAATCACCTCTCGGAAGAAAGCCCAAAATGACATGTGAAAATAATATTAAACCATTTACCAGATGTC CAGCAATATAAAAATAGACCTCACATGCTACCCTTCACATGCTGATTCTCTTGCCTTGCTGTTTAAGGATCCAGTTTCTTATGTTAAACATTTTCCTTAC CTTTTGCAATAATATTATTGGCCATATACTAAATTCTCATTCACTTAGCTTTCTAAGAATTCTTTGAGGTTGGAATCCTGAAATCATAAAGCTACCAGAT CTGCACAACAGCAGTGGTAGTATCTGAGCCCAAACTCTGAGACGCTCTAGAGTTTTAGTTTACAAACATGAGCCAGACCAAACCTGACCTGGTGAAAATC AATAGGTAATAAACTGCTTGTATATGATAGCAGTTCAAGGGCTTTCTGGGTTCCATTTCACTGAGGAAATGAAAATATAACTGATTAGCCAAGACAGAGT GGCAATAAGGAATAACTGATCCTCCTCCAAGTTGCAGTGAGCAAGCCCTCAAGCCTACCTCATTCCTGAAGAGTTGAAGGAGAAAATGCCGTGCTAATTT TCTGCCCTGCTATTTTTAACCTGAAATTTAGAATTACATCAGGTATTCAAAGAATGTTCCCTATCAAAGGAAAATCTGTAAACGATGACTGCAAAAAGCA AGTGAAATGATGCAAAGAGAAAATATTTGCAAAACAGAATCTAACCAGACATCATCATGAAGATAAAATGGCATCTCTTCTGTGTGGCCTGGGTGTGCTT GGACAATCCTGTCACACGTTTCTATTAGGACATGTTGCCCTTTTGAGGATTCACTCTATGTTGGCCAGATGGTTTAACTGATTAAACAATTGAATCAATT TATTTTGCTTTTTGAATTGACCAGATATTTAACTAAATGTACTGGGTTTGGCATTTTAGACACACTGCCTTAGATTCTTGTAGTGCATGATGACTTTGAA AATGTTTGGCCATTTTAGTTAAAATGCAGGGTAACATTTGATGCAGCCATGATAACAGGAAAAATCTGTTCTGTTCTAAAAATGTTTCTAGCAATAGAAG TATTTCTGGCTAAGAGAATACTCTTGACTTGTAGGGAGGCTCCCTCGGAATAAATGTATGCAACACAAATAAGGCATTTTATTTTTTAAAAGATTGTCTA TATAAGATACACTTATTAAATAAAGAAATTGTTGGTGAATGCTCTGAAAA

PTPRB.F6 (forward primer)
PTPRB.R6 (reverse primer)
Single exon skipping

Frame 0

EA*TVAKWKMEAEFYMVILTCLIFRNSEGFQIV HVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDE KLLHVKSALCLAISNSSRGPSRSAILDRCSQAP RWTCYDQEGFLEVENASLFLQKQGSRVVVKKAR KYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVS VRSTRNTAPPQILTTFNAVPDGLVFLIRNTTEA FIRNAAENYSQNSSERQHPNLHMTGITDTSWVL STTQPFSSTTEETGLAEPERCNFTLAESKASSHS VSIQWRILGSPCNFSLIYSSDTLGAALCPTFRI DNTTYGCNLQDLQAGTIYNFRIISLDEERTVVL QTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVT SYEVQLFDENNQKIQGVQIQESTSWNEYTFFNL TAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPV KDIGISTKANSLLISWSHGSGNVERYRLMLMDKG ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTE AAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSL KVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWI TETHFKELVPGRLYQVTVSCVSGELSAQKMAVG RTFPDKVANLEANNNGRMRSLVVSWSPPAGDWE QYRILLFNDSVVLLNITVGKEETQYVMDDTGLVP GRQYEVEVIVESGNLKNSERCQGRTVPLAVLQL RVKHANETSLSIMWQTPVAEWEKYIISLADRDL LLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFT NWTQAQGDVEFYQVLLIHENVVIKNESISSETS RYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGR TVPDKVQGVSVSNSARSDYLRVSWVHATGDFDH YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGR LYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLR NRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVF PPFHLVNTATEYRFTSLTPGRQYKILVLTISGD VQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNW TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEH TFHRLEAGEQYQIMIASVSGSLKNQINVVGRTV PASVQGVIADNAYSSYSLIVSWQKAAGVAERYDI LLLTENGILLRNTSEPATTKQHKFEDLTPGKKY KIQILTVSGGLFSKEAQTEGRTVPAAVTDLRIT ENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQE RAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGEL SNESFIFGRTVPASVSHLRGSNRNTTDSLWFNW SPASGDFDFYELILYNPNGTKKENWKDKDLTEWR FQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP SPPSLMSFADIANTSLAITWKGPPDWTDYNDFE LQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSY QFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNL HCRPQNSTAIACSWIPPDSDFDGYSIECRKMDT QEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQ SAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKD VLISKSSINFTVNCSWFSDTNGAVKYFTVVVRE ADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY FASKCAENPNSNSKSFNIKLGAEMESLGGKCDP TQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKE FTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLF LIGMLVAVVALLICRQKVSHGRERPSARLSIRR DRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMK LQADSNYLLSKEYEELKDVGRNQSCDIALLPENR GKNRYNNILPYDATRVKLSNVDDDPCSDYINAS YIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQN VHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDL ILQMLSESVLPEWTIREFKICGEEQLDAHRLIR HFHYTVWPDHGVPETTQSLIQFVRTVRDYINRS PGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKD SVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR DVLRARKLRSEQENPLFPIYENVNPEYHRDPVY SRH*ECT*RAPG*KLFTV*FVFKNLLHALQRCQL FLLILCIIY*SGECLKFYII*R*QILLYIVVFC SFFCKYVFFIMFNIKLYIILFFHTKVFMTCST* N*FNLYDRTTGKMHMEVVAETILQAMFSTCFDIH WTGKRAGLERANTMARFAALLSHESREPTDMS* LAIRTNVTVKKRIRGREKKELSSTKAELDACV* TSCSLSPFSFQGFKPKWSAQGSCNLQCKPRMVGC RVEGSDRE*FQTEVMNSFC**DASYTQTGNITC KALSTVIRDPFIAFMVWSVNIHTHTVMYLYTLV SVSFSVVSIPRKVTIIHSYLISH*KNIMVADCAP H*KA*CQHFHRNDYKHHI**I*KQ*QKQKQWSS VKFSKLLLVNQ*SQNVK*SPKVAFNNKRHYILY QVYLQYLCLTYFDYNKFQ*VRKYFLHQGPVPTAF LGKI*KEFVRNLHRYLRR*AGDVCLFHTTNFSV INLGIRGQVC*WHSFLCIKSIFLFKVYIFVTYH KVRK*IQRM*LT**LKIIDYT*NSSL*LNNSTPN LEIFPRLFEVYKNVKHNHKLQRFTVSLCSMLL* NDSLKL*FCIKELSESSGNEKEQHMCKCSRCTT SEKIEVRDLQRVASIRNHLSYIEKKKEKKQNFTL MLLDAKHINAWKDTFIFDFSFTQKTSSKYLQPA RHCSRIYTFLLT*RESS*S*DCCYYLQLSLKDS LIKGMG*LSQSRTVVTFHRPHTGKC*CYFNSKPL DLGERAINCTNQELKP*KKPMHL***ITLTYSG NI*GSIRIM*MDMTGKNRRFF*SNPTQEMFIPT LHLILNLLSNKYFTIRSYSWED*IYN*LIY*I*E KKKVFLDIQLYWIYFHLIASCVMSW*TLHFLSW WASCLCTCAVHFNHQDFKVLLSYQILGESHLAS **LFFQVRYN*LL*PHLIKSILYCHSVVLWKAAN CSALESEFSKTHLSYLGLHIFVLSNSLSLKPLS PSVLLLAPLLLLEYVCFPS*M*FLSTVHIIFYT HEYNFIVLSGSTSSKR*P*FHFFLK*SLALLPRL ECSGTISAHYNLRLPGSSDSALASQVAGITGAC HHVWLIFVFLVEMGFHHVGQAGLELVTLGDPPT STSQSARITRVSHRTWPIHF*ILKGTQHTDIFGA VFFGRVFDKFCNHLSEESPK*HVKIILNHLPDV QQYKNRPHMLPFTC*FSCLAV*GSSFLC*TFSL PFAIILLAIY*ILIHLAF*EFFEVGILKS*SYQI CTTAVVVSEPKL*DALEF*FTNMSQTKPDLVKI NR**TACI**QFKGFLGSISLRK*KYN*LAKTE WQ*GITDPPPSCSEQALKPTSFLKS*RRKCRANF LPCYF*PEI*NYIRYSKNVPYQRKICKR*LQKA SEMMQRENICKTESNQTSS*R*NGISSVWPGCA WTILSHVSIRTCCPFEDSLYVGQMV*LIKQLNQF ILLFELTRYLTKCTGFGILDTLP*ILVVHDDFE NVWPF*LKCRVTFDAAMITGKICSVLKMFLAIE VFLAKRILLTCREAPSE*MYATQIRHFIF*KIVY IRYTY*IKKLLVNALK

Frame 1

KHEQLLSGKWRLNFTW*FLPA*SSGTQKGFRLS MSRNNSVFSKMRKWSWAHATGPSRTSSGCGLRM KSSFMLNLHCAWPSPTLPAAPPAQPSWTAVPRHP DGPAMIRKASLRWKMPLSFSRNKAPE*WSRRPG NTSIAG*K*MSTRRENWSMKASVYKKLAWEQKF R*GALETRLHPRFSLPLMQFQMAWYSLLGIPQRP SSEMLQKTTAKTAARGSIPICT*LELQTHHGFC RLLSPSPAPLKRLDWRSQRDVTSPWRSPRPPAI LCLSSGEFWAHPVTLASSIAVTPWGPRCALPFG* TTPHTDVTFKIYKQEPSITSGLFLWMKREQWSC KQILYLLLGLESVKRRRLQPACMFGGLLLPEKS PHMRCNYLMKITKRYRGFKFKKVLHGMNTLFSIS LLVVNTILPSQLFLEENVLFQFIPMDQQCHLQ* KILVFPQKPILS*FPGPMVLGMWNDTG*C*WIK GS*FMAVLWTNMLLPMLFTG*PLATSTTSLL*LR LQGCKTTGGN*SGQPPWKSQI*R*QMMAV*PL* KSNGKDLLEMWILTISPCLTKGPSRNPEY*HLG LLKLTLKS*SPVDFIKLLSAVSLVNCLLRRWQWA EHFQTKLQTWRQTIMAG*GLL**AGRPLLETGS SIGSYSSMILWCCSTSLWERKKHSMSWMTRGSY REDSMRWKSLLRVEI*RILSVAKAGQSPWLSSSF VSNMPMKPH*VSCGRPL*QNGRNTSFP*LTETS Y*STSHSPKMPKNSLLLTWCLDENTWLQSPVLV ET*KIPLQ*KEEQCLPK*LTCMWPTKE*PVVCLL TGPRHKET*NFTKSY*SMKMWSLKMKASPVRPA DTASTLSSPAACTPWW*QQ*VEGSLPDKWLWRE EQCLTKSRESVLATQPGVTI*GYPGCMPLETLIT MKSPLKTKTTSFKLKAFPSQKTNVYLFS*SLDG CTVSLLLQKVDNMKPMNKGMGEQFQSLLRI*HC ATGALRTCM*LGQELMGMSTNMRSSCSSMT*KYF LLFTL*IPQPSIDLLP*HQAANTKFLS*RLAGM YSSQPSLRASQFLVLSKIFTFLPMEQQIA*R*T GLLVGETLIPTRCRHSGTVKRLTLRLFPSTSLST RSTDWRPGSSTRS*LPQSAGP*RIR*MWLGGQF QHLSKE*LQTMHTAVIP***VGKKLLVWQKDMI SCF*LKMESFCATHQSQPPLSNTNLKI*HQARNT RYRS*LSVEASLARKPRLKAEQSQQLSPT*GSQ RTPPGTCPSAGPPQRGSSAGTTSFCTTQMGISR RELKLTH*SRASLSRTCYKAECTRW*L*LTVGSC LMSLSYLVEQSQPL*VISGGPIGTRQTAFGSTG VQPLGTLTFMS*FSIIPMAQRRKTGKTRT*RSG GFKALFLEGSTCCGW*LTVEISAIKSQRRAEQLQ VLPVLCHLLTLQTHPWPSRGKGPQTGQTTTTLS CSGCPEMHLLSSTPTTTENQKDALCMVFVQGDP INSTSRLSVVIPGKLTANQFLDL*GQSLTRYKTC IAGLRTPRPLPVLGSLLILTLMVIVLNAGKWTP KKLSFPESWRKKNLCSTS*C*CPIRGTWCPSKC SRPA*PARWLKTALSQ**TAPLLHPHTFV*MKRM C*LASLPSTLLSTAAGSATPMEL*NTSQWW*ER LMAVMS*SQNSSTLSLPTWSTGTMPPFGCIRLI ILPANVPKILTATPRVLTLSLEQRWRA*VENAIP LSKNSVMDH*SHTLPTESAFELLHSSLMRT*RN SQSHSIQTHFFLYPSLLNQSPCLELLKV*VLVC F*LAC*WLLLPY*SADRK*AMVEKDPLPV*AFVG IDHYLST*TWARKVTGKLLVQ*K*ISLKGIS*S YRLTPTTFYPRNTRS*KTWAETSHVTLHSCRRI EGKIDTTIYCPMMPRE*SSPM*MMILALTTSMPA TSLATTSEENTLSLRDRFLAPRMTSGKWCGNKT FTTSSW*PSVLRRAE*SVIITGQRTRIPSTMGT SSCRCSQSPSCLSGPSGSLRYAVRNSLMHTDSSA TFTIRCGQTMESQKPPSL*SSL*ELSGTTSTEA RVLGPLWCTAVLVWVGLEPLLHWTESSSS*TPK TLWTFMEQCTT*DFTGFTWSRLSVSMSTYISV*E MSSEQESYGVNKKTPCFQSMKM*IQSITEIQSI QGIENVPEELLDKNYSLCDLFLKTCFMPYRGAS YFC*YYV*FINLENV*NFI*FKGNRYYCT*LYFV VSSVNMYFS*CLILSFI*YYFSTLKCS*LVLHK TNSTCMTGLLVKCIWRWWQRQSFRPCFLPVLIF TGQEKGQG*REQILWLDLLHCCPMNLESQQTCPN LLLGQM*QSKKGLEGGRKKN*AVPKLN*MLVSE LVALSLLSPSRDSSQSGQLRDHVTCSASPGW*D AGLRVLIENDSKQK**IPFVNKMPAIPRLET*HA KHYLQ*LEILSLHSWCGV*TSTPIL*CIYTH*F LSHFQWSPFLEKSQLSIPT*FPIKRILW*QIVP LIKRLNANIFIEMTTNIIYSKFKNNSKNKNSGLQ *NFQNFF**INEVKMSSNHPKLHLITKGTTYCT KFIFNICALLTLTITNSNESESISFIKVQFRQH SWEKFERSLYGIFIDT*EDELEMFAFFTLQIFL* *TWELEVKFVDGIASFA*RVYFFSKYIFL*PTI KSVSEYNECN*HNN*KSLTIPKIVLYN*ITLHP IWKFFQGYLKFTKM*SIIISFKDSQFHCAQCSCE MTVLSSDSVSRN*VNLLEMKRNNICVSAVDVPP ARK*RSEIYNVWHPLEITFPTLKRKKRKSRILH *CCLMQSTLMLGRIHSFSTFHSLRKLLVSICNLL GTVPESTHFYSHKENPHKVRIVVTTFN*A*KTA SSREWDN*ASLGQWSPSTGHTLESANATLIANL WI*EREQLIAQTRS*NHKKNLCICNSK*HSRTLA TSRVVSELCKWT*QGKIVGFFSLIQPRKCLFLP YT*F*TFLATNISLFAPTPGKTKYIIDLFIKFR RKKKFSLTFSSIGFISI*LHHVLCLGKHSISCLG GHPVCVPVQYTLIIKTSKCF*AIKSWESPI*HL NNYFSKFVIINSFNLISLNQFCIVILLFSGKQP IVQLLNQNFQRLTSLTWACTYLS*VILYPLNL*V PLFYYLPHSSYLNMFVFPVECDFYLLFILSFIP MSIIS*SFQVPHHQRDDHNFTFF*NEVLLCCPG WSAVAQSQLTTTSASQVQAILP*PPK*LELQVPA TMSG*FLCF**RWGFTMLARLVLNS*P*VIHPP QPPKVLGLQE*ATAPGQFTFKY*KAHSTQTFSG QFSLGGSLINFVITSRKKAQNDM*K*Y*TIYQMS SNIKIDLTCYPSHADSLALLFKDPVSYVKHFPY LLQ*YYWPYTKFSFT*LSKNSLRLES*NHKATR SAQQQW*YLSPNSETL*SFSLQT*ARPNLTW*KS IGNKLLVYDSSSRAFWVPFH*GNENITD*PRQS GNKE*LILLQVAVSKPSSLPHS*RVEGENAVLI FCPAIFNLKFRITSGIQRMFPIKGKSVNDDCKKQ VK*CKEKIFAKQNLTRHHHEDKMASLLCGLGVL GQSCHTFLLGHVALLRIHSMLARWFN*LNN*IN LFCFLN*PDI*LNVLGLAF*THCLRFL*CMMTLK MFGHFS*NAG*HLMQP**QEKSVLF*KCF*Q*K YFWLREYS*LVGRLPRNKCMQHK*GILFFKRLS I*DTLIK*RNCW*ML*K

Frame 2

SMNSC*VENGG*ILHGDSYLLDLQELRRVSDCP CPETTVSFQK*ESGRGLMQQDHPEPAVDVD*G* KAPSC*ICTVLGHLQLFPRPLPLSHLGPLFPGT PMDLL*SGRLP*GGKCLSLSPETRLQSSGQEGQE IPP*LDENRCQQGGKTGQ*KPLFTKSWPGSRSF GEEH*KHGSTPDSHYL*CSSRWPGIPY*EYHRG LHQKCCRKLQPKQQREAASQSAHDWNYRHIMGFV DYSALLQHH*RDWTGGAREM*LHPGGVQGLQPF CVYPVENFGLTL*L*PHL*Q*HPGGRVVPYLSD RQHHIRM*PSRFTSRNHL*LQDYFSG*RENSGLA NRSFTSC*VWSQ*REDDFNQLACLVDSFFRKSH LI*GAII**K*PKDTGGSNSRKYFME*IHFFQS HCW**IQYCHHSCFWRKTFFFSLYQWINSAISSE RYWYFHKSQFSPDFLVPWFWECGTIPADANG*R DPSSWRCCGQTCYFLCFSRADPWLPLQPHCYD* GCRAAKLQVETSQDSPHGSLKSEGDK*WQFDLSK SQMAKTSWKCGFLQYHPVSQRDHQGIQSISTLD Y*NSL*RVSPRSTLSSYCQLCLW*TVCSEDGSG QNISRQSCKPGGKQ*WQDEVSCSELVAPCWRLGA VSDPTLQ*FCGAAQHHCGKGRNTVCHG*HGART GKTV*GGSHC*EWKFEEF*ALPRQDSPPGCPPA SCQTCQ*NLTEYHVADPCSRMGEIHHFPS*QRPL TDPQVTLQRCQRIHFY*PGAWTKIHGYSHQY*W RLKKFLFSKRKNSACPSD*LACGQPRNDQ*SVY *LDPGTRRRRILPSLTDP*KCGH*K*KHLQ*DQQ IQLPLSQVRQPVLRGGNNSEWRDLFPTSGCGGK NSA*QSPGSQC*QLSQE*LFKGILGACHWRL*S L*SHH*KQKQLHSN*KHSQVRKRMCICSASPWTV VQCHCYYKKWTI*SQ*TREWENNSRAC*GSNIA QQEH*GLACDLVRS*WGCRPI*DPAALQ*HESI SSFSPCKYRNRVSIYFPNTRPPIQNSCLDD*RGC TAVSLH*GLHSS*CCQKYSHFSQWSNR*PDGEL DSWWGRR*FLHGVGIQAQSKG*LSDYSQARL*A HVPQTGGRGAVPDHDCLSQRVPEESDKCGWADSS SICPRSNCRQCIQQLFLNSKLAKSCWCGRKI*Y PASN*KWNPSAQHIRASHH*ATQI*RSNTRQEI QDTDPNCQWRPL*QGSPD*RPNSPSSCHRPEDHR ELHQAPVLPLDRLRGGAQLVQHLFVQPRWESPG ESSS*PTSPELLFPELATRQNVQDGDCNSQWGA V**VFHIW*NSPSLCESSQGVQSEHDRQPLVQLE SSLWGL*LL*ADSL*SQWHKEGKLERQGPDGVA VSRPCSWKEVRAVGGNSQWRSQQ*SHSGEQNSS KSSQSYVIC*HCKHILGHHVERAPRLDRLQRL*A AVVAQRCTYCLQPLQQQKIRRTHCVWSSSREIL SIQRQDCQW*FLENLQQTNFWICEDKA*QDTKP ALPASELHGHCLFLDPS*F*L*WL*Y*MPENGHP RS*VFQKAGERKISAQHHDASAP*EVPGVHQSA VGRHDQRGG*RQHYHNDRPPPSSTPTHSCE*KG CAN*QVFHQLYCQLQLVQRHQWSCEILHSGGERG *WQ**AEARTAAPSPFLPGVQAQCLHSGVSD*L FCQQMCRKS*QQLQEF*H*AWSRDGEPRWKMRS HSAKIL*WTTEATHCLQNQHSSFYTAL**GPEGI HKATLFRHIFFFTHHY*IRALVWSY*RCECWSV FNWHASGCCCLIDLQTESEPWSRKTLCPSEHS* GSTIICPLKPGPER*PENFLSNKNKSV*RAFHEA TG*LQLPSIQGIRGVKRRGPKPVM*HCTLAGE* REKSIQQYIAL*CHASEALQCR**SLL*LHQCQ LHPWQQLQKRIHCHSGTASWHQG*LLENGVGTKR SQHRHGDPVC*EGPSKV*SLLASGPGFPLLWGP HPADALRVRPA*VDHPGV*DMR*GTA*CTQTHP PLSLYGVARPWSPRNHPVSDPVCENCQGLHQQKP GCWAHCGALQCWCG*DWNLYCIGPNPPAVRLQR LCGHLWSSARPKTSQGSHGPD*VSVCLPTSVCK RCPQSKKATE*TRKPLVSNL*KCESRVSQRSSLF KALRMYLKSSWIKIIHCVICF*KLASCPTEVPA ISVDTMYNLLIWRMFKILYNLKVTDIIVHSCIL *FLL*ICIFHNV*Y*ALYNTIFPH*SVHDLFYIK LIQPV*QDYW*NAYGGGGRDNPSGHVFYLF*YS LDRKKGRARESKYYG*ICCIAVP*ISRANRHVL TCY*DKCDSQKKD*REGEKRIKQYQS*TRCLCLN *LLSLSFLLPGIQAKVVSSGIM*LAVQAQDGRM QG*GF**RMIPNRSDEFLLLIRCQLYPDWKHNM QSTIYSD*RSFHCIHGVECEHPHPYCNVFIHTSF CLIFSGLHS*KSHNYPFLLDFPLKEYYGSRLCP SLKGLMPTFS*K*LQTSYIVNLKTIAKTKTVVF SKIFKTSFSKSMKSKCQVITQSCI**QKALHTVP SLSSIFVPYLL*L*QIPMSQKVFPSSRSSSDSI PGKNLKGVCTESS*IPEKMSWRCLPFSHYKFFC NKLGN*RSSLLMA*LPLHKEYISFQSIYFCNLP* SP*VNTTNVIDIIIENH*LYLK*FFIIK*LYTQ SGNFSKVI*SLQKCEA*S*ASKIHSFIVLNALV K*QS*ALILYQGTK*IFWK*KGTTYV*VQ*MYHQ RENRGQRSTTCGIH*KSPFLH*KEKREKAEFYT NVA*CKAH*CLEGYIHFRLFIHSENF**VSATC *ALFQNLHISTHIKRILIKLGLLLLPSIELKRQP HQGNGITEPV*DSGHLPQATHWKVLMLL**QTS GSRRESN*LHKPGVKTIKKTYASVIVNNTHVLW QHLG*YQNYVNGHDREKS*VFLV*SNPGNVYSYP TPNFKPS*QQIFHYSLLLLGRLNI*LTYLLNLG EKKSFP*HSALLDLFPFNCIMCYVLVNTPFPVL VGILSVYLCSTL*SSRLQSAFELSNLGRVPSSIL IIIFPSSL*LTPLTSSH*INFVLSFCCSLESSQ LFSS*IRIFKDSPLLPGLAHICPK*FSIP*TSE SLCFITCPTPPT*ICLFSQLNVIFIYCSYYLLYP *V*FHSPFRFHIIKEMTIISLFFEMKSCSVAQA GVQWHNLSSLQPPPPRFKRFCLSLPSSWNYRCL PPCLANFCVFSRDGVSPCWPGWS*TRDLR*STHL NLPKC*DYKSEPPHLANSLLNTKRHTAHRHFRG SFLWEGL**IL*SPLGRKPKMTCENNIKPFTRC PAI*K*TSHATLHMLILLPCCLRIQFLMLNIFLT FCNNIIGHILNSHSLSFLRIL*GWNPEIIKLPD LHNSSGSI*AQTLRRSRVLVYKHEPDQT*PGEN Q*VINCLYMIAVQGLSGFHFTEEMKI*LISQDRV AIRNN*SSSKLQ*ASPQAYLIPEELKEKMPC*F SALLFLT*NLELHQVFKECSLSKENL*TMTAKS K*NDAKRKYLQNRI*PDIIMKIKWHLFCVAWVCL DNPVTRFY*DMLPF*GFTLCWPDGLTD*TIESI YFAF*IDQIFN*MYWVWHFRHTALDSCSA**L* KCLAILVKMQGNI*CSHDNRKNLFCSKNVSSNRS ISG*ENTLDL*GGSLGINVCNTNKAFYFLKDCL YKIHLLNKEIVGECSE

Sequence PTPRB.aAug05

GAAGCATGAACAGTTGCTAAGTGGAAAATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGAAGGGTTTCAGATTGTCC ATGTCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTGGGCTCATGCAACAGGACCATCCAGAACCAGCAGTGGATGTGGACTGAGGATGA AAAGCTCCTTCATGTTAAATCTGCACTGTGCTTGGCCATCTCCAACTCTTCCCGCGGCCCCTCCCGCTCAGCCATCTTGGACCGCTGTTCCCAGGCACCC CGATGGACCTGCTATGATCAGGAAGGCTTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGCTCCAGAGTAGTGGTCAAGAAGGCCAGGA AATACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAGGGAAAACTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTC GGTGAGGAGCACTAGAAACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGCCTGGTATTCCTTATTAGGAATACCACAGAGGCC TTCATCAGAAATGCTGCAGAAAACTACAGCCAAAACAGCAGCGAGAGGCAGCATCCCAATCTGCACATGACTGGAATTACAGACACATCATGGGTTTTGT CGACTACTCAGCCCTTCTCCAGCACCACTGAAGAGACTGGACTGGCGGAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTC TGTGTCTATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACCTTTCGGATA GACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGC AAACAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCAC CTCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTTCATGGAATGAATACACTTTTTTCAATCTC ACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGA AAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGG GATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAG GCTGCAGGGCTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGACCTCTCTAA AAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGAT TACTGAAACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGC AGAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGAGACTGGGAGC AGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACC GGGAAGACAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTT CGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCT TACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGG AGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTGCATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACT AACTGGACCCAGGCACAAGGAGACGTAGAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCA GATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAG AACAGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAAC TATGAGGTAACATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTCACCCCAGGCCGCC TCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCTTCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAG CAACTCAGCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAACAACTTCATT CAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAAT ATGAAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTC AGGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCTTTTCACCTTGTAAATACCGCAACCGAGTAT CGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCTTGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTC CTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGT GTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAG ATCATGATTGCCTCAGTCAGCGGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAGCATCTGTCCAAGGAGTAATTGCAGACAATGCAT ACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTGGCAGAAAGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAA CACATCAGAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATACAAGATACAGATCCTAACTGTCAGTGGAGGCCTCTTT AGCAAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCG CCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTC TTTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCTAATGAGTCTTTCATATTTGGTAGAACAGTCCCA GCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGACAGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGA TTCTCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCT GTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCA AACACATCCTTGGCCATCACGTGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTACTGTCTTCA ACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTG GAAAACTTACAGCAAACCAATTTTTGGATCTGTGAGGACAAAGCCTGACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGT TCTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGTTGAGTTTTCCAGAAAGCTGGAGAAAGAAA AATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTGGTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAG CACTATCACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTGCTAATTAGCAAGTCTTCCATCAACTTTACTGTC AACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTGGTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGC ACCCTCTCCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCCTAACAGCAA CTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGATCCCACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCA CACACTGCCTACAGAATCAGCATTCGAGCTTTTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGACACATTTTTTTCTT TACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTGGTCTGTTTTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATT GATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAG AAAGGTAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAAGGAAT ACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGA TGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGGCAACAACTTCAGAAGAGAATACATT GTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAGA AGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGA GTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTC CCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTG GTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAG ACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAA GAAAACCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCCTGGAT AAAAATTATTCACTGTGTGATTTGTTTTTAAAAACTTGCTTCATGCCCTACAGAGGTGCCAGCTATTTCTGTTGATACTATGTATAATTTATTAATCTGG AGAATGTTTAAAATTTTATATAATTTAAAGGTAACAGATATTATTGTACATAGTTGTATTTTGTAGTTTCTTCTGTAAATATGTATTTTTCATAATGTTT AATATTAAGCTTTATATAATACTATTTTTCCACACTAAAGTGTTCATGACTTGTTCTACATAAAACTAATTCAACCTGTATGACAGGACTACTGGTAAAA TGCATATGGAGGTGGTGGCAGAGACAATCCTTCAGGCCATGTTTTCTACCTGTTTTGATATTCACTGGACAGGAAAAAGGGCAGGGCTAGAGAGAGCAAA TACTATGGCTAGATTTGCTGCATTGCTGTCCCATGAATCTCGAGAGCCAACAGACATGTCCTAACTTGCTATTAGGACAAATGTGACAGTCAAAAAAAGG ATTAGAGGGAGGGAGAAAAAAGAATTAAGCAGTACCAAAGCTGAACTAGATGCTTGTGTCTGAACTAGTTGCTCTCTCTCTCCTTTCTCCTTCCAGGGAT TCAAGCCAAAGTGGTCAGCTCAGGGATCATGTAACTTGCAGTGCAAGCCCAGGATGGTAGGATGCAGGGTTGAGGGTTCTGATAGAGAATGATTCCAAAC AGAAGTGATGAATTCCTTTTGTTAATAAGATGCCAGCTATACCCAGACTGGAAACATAACATGCAAAGCACTATCTACAGTGATTAGAGATCCTTTCATT GCATTCATGGTGTGGAGTGTGAACATCCACACCCATACTGTAATGTATTTATACACACTAGTTTCTGTCTCATTTTCAGTGGTCTCCATTCCTAGAAAAG TCACAATTATCCATTCCTACTTGATTTCCCATTAAAAGAATATTATGGTAGCAGATTGTGCCCCTCATTAAAAGGCTTAATGCCAACATTTTCATAGAAA TGACTACAAACATCATATATAGTAAATTTAAAAACAATAGCAAAAACAAAAACAGTGGTCTTCAGTAAAATTTTCAAAACTTCTTTTAGTAAATCAATGA AGTCAAAATGTCAAGTAATCACCCAAAGTTGCATTTAATAACAAAAGGCACTACATACTGTACCAAGTTTATCTTCAATATTTGTGCCTTACTTACTTTG ACTATAACAAATTCCAATGAGTCAGAAAGTATTTCCTTCATCAAGGTCCAGTTCCGACAGCATTCCTGGGAAAAATTTGAAAGGAGTTTGTACGGAATCT TCATAGATACCTGAGAAGATGAGCTGGAGATGTTTGCCTTTTTCACACTACAAATTTTTCTGTAATAAACTTGGGAATTAGAGGTCAAGTTTGTTGATGG CATAGCTTCCTTTGCATAAAGAGTATATTTCTTTTCAAAGTATATATTTTTGTAACCTACCATAAAGTCCGTAAGTGAATACAACGAATGTAATTGACAT AATAATTGAAAATCATTGACTATACCTAAAATAGTTCTTTATAATTAAATAACTCTACACCCAATCTGGAAATTTTTCCAAGGTTATTTGAAGTTTACAA AAATGTGAAGCATAATCATAAGCTTCAAAGATTCACAGTTTCATTGTGCTCAATGCTCTTGTGAAATGACAGTCTTAAGCTCTGATTCTGTATCAAGGAA CTAAGTGAATCTTCTGGAAATGAAAAGGAACAACATATGTGTAAGTGCAGTAGATGTACCACCAGCGAGAAAATAGAGGTCAGAGATCTACAACGTGTGG CATCCATTAGAAATCACCTTTCCTACATTGAAAAGAAAAAAGAGAAAAAGCAGAATTTTACACTAATGTTGCTTGATGCAAAGCACATTAATGCTTGGAA GGATACATTCATTTTCGACTTTTCATTCACTCAGAAAACTTCTAGTAAGTATCTGCAACCTGCTAGGCACTGTTCCAGAATCTACACATTTCTACTCACA TAAAGAGAATCCTCATAAAGTTAGGATTGTTGTTACTACCTTCAATTGAGCTTAAAAGACAGCCTCATCAAGGGAATGGGATAACTGAGCCAGTCTAGGA CAGTGGTCACCTTCCACAGGCCACACACTGGAAAGTGCTAATGCTACTTTAATAGCAAACCTCTGGATCTAGGAGAGAGAGCAATTAATTGCACAAACCA GGAGTTAAAACCATAAAAAAAACCTATGCATCTGTAATAGTAAATAACACTCACGTACTCTGGCAACATCTAGGGTAGTATCAGAATTATGTAAATGGAC ATGACAGGGAAAAATCGTAGGTTTTTTTAGTCTAATCCAACCCAGGAAATGTTTATTCCTACCCTACACCTAATTTTAAACCTTCTTAGCAACAAATATT TCACTATTCGCTCCTACTCCTGGGAAGACTAAATATATAATTGACTTATTTATTAAATTTAGGAGAAAAAAAAAGTTTTCCTTGACATTCAGCTCTATTG GATTTATTTCCATTTAATTGCATCATGTGTTATGTCTTGGTAAACACTCCATTTCCTGTCTTGGTGGGCATCCTGTCTGTGTACCTGTGCAGTACACTTT AATCATCAAGACTTCAAAGTGCTTTTGAGCTATCAAATCTTGGGAGAGTCCCATCTAGCATCTTAATAATTATTTTTCCAAGTTCGTTATAATTAACTCC TTTAACCTCATCTCATTAAATCAATTTTGTATTGTCATTCTGTTGTTCTCTGGAAAGCAGCCAATTGTTCAGCTCTTGAATCAGAATTTTCAAAGACTCA CCTCTCTTACCTGGGCTTGCACATATTTGTCCTAAGTAATTCTCTATCCCTTAAACCTCTGAGTCCCTCTGTTTTATTACTTGCCCCACTCCTCCTACTT GAATATGTTTGTTTTCCCAGTTGAATGTGATTTTTATCTACTGTTCATATTATCTTTTATACCCATGAGTATAATTTCATAGTCCTTTCAGGTTCCACAT CATCAAAGAGATGACCATAATTTCACTTTTTTTTGAAATGAAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTACAACCT CCGCCTCCCAGGTTCAAGCGATTCTGCCTTAGCCTCCCAAGTAGCTGGAATTACAGGTGCCTGCCACCATGTCTGGCTAATTTTTGTGTTTTTAGTAGAG ATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCGTGACCTTAGGTGATCCACCCACCTCAACCTCCCAAAGTGCTAGGATTACAAGAGTGAGCC ACCGCACCTGGCCAATTCACTTTTAAATACTAAAAGGCACACAGCACACAGACATTTTCGGGGCAGTTTTCTTTGGGAGGGTCTTTGATAAATTTTGTAA TCACCTCTCGGAAGAAAGCCCAAAATGACATGTGAAAATAATATTAAACCATTTACCAGATGTCCAGCAATATAAAAATAGACCTCACATGCTACCCTTC ACATGCTGATTCTCTTGCCTTGCTGTTTAAGGATCCAGTTTCTTATGTTAAACATTTTCCTTACCTTTTGCAATAATATTATTGGCCATATACTAAATTC TCATTCACTTAGCTTTCTAAGAATTCTTTGAGGTTGGAATCCTGAAATCATAAAGCTACCAGATCTGCACAACAGCAGTGGTAGTATCTGAGCCCAAACT CTGAGACGCTCTAGAGTTTTAGTTTACAAACATGAGCCAGACCAAACCTGACCTGGTGAAAATCAATAGGTAATAAACTGCTTGTATATGATAGCAGTTC AAGGGCTTTCTGGGTTCCATTTCACTGAGGAAATGAAAATATAACTGATTAGCCAAGACAGAGTGGCAATAAGGAATAACTGATCCTCCTCCAAGTTGCA GTGAGCAAGCCCTCAAGCCTACCTCATTCCTGAAGAGTTGAAGGAGAAAATGCCGTGCTAATTTTCTGCCCTGCTATTTTTAACCTGAAATTTAGAATTA CATCAGGTATTCAAAGAATGTTCCCTATCAAAGGAAAATCTGTAAACGATGACTGCAAAAAGCAAGTGAAATGATGCAAAGAGAAAATATTTGCAAAACA GAATCTAACCAGACATCATCATGAAGATAAAATGGCATCTCTTCTGTGTGGCCTGGGTGTGCTTGGACAATCCTGTCACACGTTTCTATTAGGACATGTT GCCCTTTTGAGGATTCACTCTATGTTGGCCAGATGGTTTAACTGATTAAACAATTGAATCAATTTATTTTGCTTTTTGAATTGACCAGATATTTAACTAA ATGTACTGGGTTTGGCATTTTAGACACACTGCCTTAGATTCTTGTAGTGCATGATGACTTTGAAAATGTTTGGCCATTTTAGTTAAAATGCAGGGTAACA TTTGATGCAGCCATGATAACAGGAAAAATCTGTTCTGTTCTAAAAATGTTTCTAGCAATAGAAGTATTTCTGGCTAAGAGAATACTCTTGACTTGTAGGG AGGCTCCCTCGGAATAAATGTATGCAACACAAATAAGGCATTTTATTTTTTAAAAGATTGTCTATATAAGATACACTTATTAAATAAAGAAATTGTTGGT GAATGCTCTGAAAA

PTPRB.F6 (forward primer)
PTPRB.R6 (reverse primer)
Single exon skipping

Frame 0

EA*TVAKWKMEAEFYMVILTCLIFRNSEGFQIV HVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDE KLLHVKSALCLAISNSSRGPSRSAILDRCSQAP RWTCYDQEGFLEVENASLFLQKQGSRVVVKKAR KYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVS VRSTRNTAPPQILTTFNAVPDGLVFLIRNTTEA FIRNAAENYSQNSSERQHPNLHMTGITDTSWVL STTQPFSSTTEETGLAEPERCNFTLAESKASSHS VSIQWRILGSPCNFSLIYSSDTLGAALCPTFRI DNTTYGCNLQDLQAGTIYNFRIISLDEERTVVL QTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVT SYEVQLFDENNQKIQGVQIQESTSWNEYTFFNL TAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPV KDIGISTKANSLLISWSHGSGNVERYRLMLMDKG ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTE AAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSL KVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWI TETHFKELVPGRLYQVTVSCVSGELSAQKMAVG RTFPDKVANLEANNNGRMRSLVVSWSPPAGDWE QYRILLFNDSVVLLNITVGKEETQYVMDDTGLVP GRQYEVEVIVESGNLKNSERCQGRTVPLAVLQL RVKHANETSLSIMWQTPVAEWEKYIISLADRDL LLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFT NWTQAQGDVEFYQVLLIHENVVIKNESISSETS RYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGR TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDN YEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGR LYTVTITTRSGKYENHSFSQERTVPDKVQGVSVS NSARSDYLRVSWVHATGDFDHYEVTIKNKNNFI QTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQ YEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEY RFTSLTPGRQYKILVLTISGDVQQSAFIEGFTV PSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTV SAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ IMIASVSGSLKNQINVVGRTVPASVQGVIADNA YSSYSLIVSWQKAAGVAERYDILLLTENGILLRN TSEPATTKQHKFEDLTPGKKYKIQILTVSGGLF SKEAQTEGRTVPAAVTDLRITENSTRHLSFRWT ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVP ASVSHLRGSNRNTTDSLWFNWSPASGDFDFYEL ILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVL WVVTHSGDLSNKVTAESRTAPSPPSLMSFADIA NTSLAITWKGPPDWTDYNDFELQWLPRDALTVF NPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSW KTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE KSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS TITMIDRPPPPPPHIRVNEKDVLISKSSINFTV NCSWFSDTNGAVKYFTVVVREADGSDELKPEQQ HPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKP HTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFS LPITTESEPLFGAIEGVSAGLFLIGMLVAVVALL ICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQ KGNRKTSCPIKINQFEGHFMKLQADSNYLLSKE YEELKDVGRNQSCDIALLPENRGKNRYNNILPYD ATRVKLSNVDDDPCSDYINASYIPGNNFRREYI VTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVE KGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGV PETTQSLIQFVRTVRDYINRSPGAGPTVVHCSA GVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLR LHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQ ENPLFPIYENVNPEYHRDPVYSRH*ECT*RAPG *KLFTV*FVFKNLLHALQRCQLFLLILCIIY*SG ECLKFYII*R*QILLYIVVFCSFFCKYVFFIMF NIKLYIILFFHTKVFMTCST*N*FNLYDRTTGK MHMEVVAETILQAMFSTCFDIHWTGKRAGLERAN TMARFAALLSHESREPTDMS*LAIRTNVTVKKR IRGREKKELSSTKAELDACV*TSCSLSPFSFQG FKPKWSAQGSCNLQCKPRMVGCRVEGSDRE*FQT EVMNSFC**DASYTQTGNITCKALSTVIRDPFI AFMVWSVNIHTHTVMYLYTLVSVSFSVVSIPRK VTIIHSYLISH*KNIMVADCAPH*KA*CQHFHRN DYKHHI**I*KQ*QKQKQWSSVKFSKLLLVNQ* SQNVK*SPKVAFNNKRHYILYQVYLQYLCLTYF DYNKFQ*VRKYFLHQGPVPTAFLGKI*KEFVRNL HRYLRR*AGDVCLFHTTNFSVINLGIRGQVC*W HSFLCIKSIFLFKVYIFVTYHKVRK*IQRM*LT **LKIIDYT*NSSL*LNNSTPNLEIFPRLFEVYK NVKHNHKLQRFTVSLCSMLL*NDSLKL*FCIKE LSESSGNEKEQHMCKCSRCTTSEKIEVRDLQRV ASIRNHLSYIEKKKEKKQNFTLMLLDAKHINAWK DTFIFDFSFTQKTSSKYLQPARHCSRIYTFLLT *RESS*S*DCCYYLQLSLKDSLIKGMG*LSQSR TVVTFHRPHTGKC*CYFNSKPLDLGERAINCTNQ ELKP*KKPMHL***ITLTYSGNI*GSIRIM*MD MTGKNRRFF*SNPTQEMFIPTLHLILNLLSNKY FTIRSYSWED*IYN*LIY*I*EKKKVFLDIQLYW IYFHLIASCVMSW*TLHFLSWWASCLCTCAVHF NHQDFKVLLSYQILGESHLAS**LFFQVRYN*L L*PHLIKSILYCHSVVLWKAANCSALESEFSKTH LSYLGLHIFVLSNSLSLKPLSPSVLLLAPLLLL EYVCFPS*M*FLSTVHIIFYTHEYNFIVLSGST SSKR*P*FHFFLK*SLALLPRLECSGTISAHYNL RLPGSSDSALASQVAGITGACHHVWLIFVFLVE MGFHHVGQAGLELVTLGDPPTSTSQSARITRVS HRTWPIHF*ILKGTQHTDIFGAVFFGRVFDKFCN HLSEESPK*HVKIILNHLPDVQQYKNRPHMLPF TC*FSCLAV*GSSFLC*TFSLPFAIILLAIY*I LIHLAF*EFFEVGILKS*SYQICTTAVVVSEPKL *DALEF*FTNMSQTKPDLVKINR**TACI**QF KGFLGSISLRK*KYN*LAKTEWQ*GITDPPPSC SEQALKPTSFLKS*RRKCRANFLPCYF*PEI*NY IRYSKNVPYQRKICKR*LQKASEMMQRENICKT ESNQTSS*R*NGISSVWPGCAWTILSHVSIRTC CPFEDSLYVGQMV*LIKQLNQFILLFELTRYLTK CTGFGILDTLP*ILVVHDDFENVWPF*LKCRVT FDAAMITGKICSVLKMFLAIEVFLAKRILLTCR EAPSE*MYATQIRHFIF*KIVYIRYTY*IKKLLV NALK

Frame 1

KHEQLLSGKWRLNFTW*FLPA*SSGTQKGFRLS MSRNNSVFSKMRKWSWAHATGPSRTSSGCGLRM KSSFMLNLHCAWPSPTLPAAPPAQPSWTAVPRHP DGPAMIRKASLRWKMPLSFSRNKAPE*WSRRPG NTSIAG*K*MSTRRENWSMKASVYKKLAWEQKF R*GALETRLHPRFSLPLMQFQMAWYSLLGIPQRP SSEMLQKTTAKTAARGSIPICT*LELQTHHGFC RLLSPSPAPLKRLDWRSQRDVTSPWRSPRPPAI LCLSSGEFWAHPVTLASSIAVTPWGPRCALPFG* TTPHTDVTFKIYKQEPSITSGLFLWMKREQWSC KQILYLLLGLESVKRRRLQPACMFGGLLLPEKS PHMRCNYLMKITKRYRGFKFKKVLHGMNTLFSIS LLVVNTILPSQLFLEENVLFQFIPMDQQCHLQ* KILVFPQKPILS*FPGPMVLGMWNDTG*C*WIK GS*FMAVLWTNMLLPMLFTG*PLATSTTSLL*LR LQGCKTTGGN*SGQPPWKSQI*R*QMMAV*PL* KSNGKDLLEMWILTISPCLTKGPSRNPEY*HLG LLKLTLKS*SPVDFIKLLSAVSLVNCLLRRWQWA EHFQTKLQTWRQTIMAG*GLL**AGRPLLETGS SIGSYSSMILWCCSTSLWERKKHSMSWMTRGSY REDSMRWKSLLRVEI*RILSVAKAGQSPWLSSSF VSNMPMKPH*VSCGRPL*QNGRNTSFP*LTETS Y*STSHSPKMPKNSLLLTWCLDENTWLQSPVLV ET*KIPLQ*KEEQCLPK*LTCMWPTKE*PVVCLL TGPRHKET*NFTKSY*SMKMWSLKMKASPVRPA DTASTLSSPAACTPWW*QQ*VEGSLPDKWLWRE EQSLPV*VE*R*TIPVVMTTSAFPGCWRPEMWIT MR*HCLMTARWFSPLSLPSLSENVPSAPSPQAA STP*P*LQGVASMKITPSAKSGQCLTKSRESVL ATQPGVTI*GYPGCMPLETLITMKSPLKTKTTSF KLKAFPSQKTNVYLFS*SLDGCTVSLLLQKVDN MKPMNKGMGEQFQSLLRI*HCATGALRTCM*LG QELMGMSTNMRSSCSSMT*KYFLLFTL*IPQPSI DLLP*HQAANTKFLS*RLAGMYSSQPSLRASQF LVLSKIFTFLPMEQQIA*R*TGLLVGETLIPTR CRHSGTVKRLTLRLFPSTSLSTRSTDWRPGSSTR S*LPQSAGP*RIR*MWLGGQFQHLSKE*LQTMH TAVIP***VGKKLLVWQKDMISCF*LKMESFCA THQSQPPLSNTNLKI*HQARNTRYRS*LSVEASL ARKPRLKAEQSQQLSPT*GSQRTPPGTCPSAGP PQRGSSAGTTSFCTTQMGISRRELKLTH*SRAS LSRTCYKAECTRW*L*LTVGSCLMSLSYLVEQSQ PL*VISGGPIGTRQTAFGSTGVQPLGTLTFMS* FSIIPMAQRRKTGKTRT*RSGGFKALFLEGSTC CGW*LTVEISAIKSQRRAEQLQVLPVLCHLLTLQ THPWPSRGKGPQTGQTTTTLSCSGCPEMHLLSS TPTTTENQKDALCMVFVQGDPINSTSRLSVVIP GKLTANQFLDL*GQSLTRYKTCIAGLRTPRPLPV LGSLLILTLMVIVLNAGKWTPKKLSFPESWRKK NLCSTS*C*CPIRGTWCPSKCSRPA*PARWLKT ALSQ**TAPLLHPHTFV*MKRMC*LASLPSTLLS TAAGSATPMEL*NTSQWW*ERLMAVMS*SQNSS TLSLPTWSTGTMPPFGCIRLIILPANVPKILTA TPRVLTLSLEQRWRA*VENAIPLSKNSVMDH*SH TLPTESAFELLHSSLMRT*RNSQSHSIQTHFFL YPSLLNQSPCLELLKV*VLVCF*LAC*WLLLPY *SADRK*AMVEKDPLPV*AFVGIDHYLST*TWAR KVTGKLLVQ*K*ISLKGIS*SYRLTPTTFYPRN TRS*KTWAETSHVTLHSCRRIEGKIDTTIYCPM MPRE*SSPM*MMILALTTSMPATSLATTSEENTL SLRDRFLAPRMTSGKWCGNKTFTTSSW*PSVLR RAE*SVIITGQRTRIPSTMGTSSCRCSQSPSCL SGPSGSLRYAVRNSLMHTDSSATFTIRCGQTMES QKPPSL*SSL*ELSGTTSTEARVLGPLWCTAVL VWVGLEPLLHWTESSSS*TPKTLWTFMEQCTT* DFTGFTWSRLSVSMSTYISV*EMSSEQESYGVNK KTPCFQSMKM*IQSITEIQSIQGIENVPEELLD KNYSLCDLFLKTCFMPYRGASYFC*YYV*FINL ENV*NFI*FKGNRYYCT*LYFVVSSVNMYFS*CL ILSFI*YYFSTLKCS*LVLHKTNSTCMTGLLVK CIWRWWQRQSFRPCFLPVLIFTGQEKGQG*REQ ILWLDLLHCCPMNLESQQTCPNLLLGQM*QSKKG LEGGRKKN*AVPKLN*MLVSELVALSLLSPSRD SSQSGQLRDHVTCSASPGW*DAGLRVLIENDSK QK**IPFVNKMPAIPRLET*HAKHYLQ*LEILSL HSWCGV*TSTPIL*CIYTH*FLSHFQWSPFLEK SQLSIPT*FPIKRILW*QIVPLIKRLNANIFIE MTTNIIYSKFKNNSKNKNSGLQ*NFQNFF**INE VKMSSNHPKLHLITKGTTYCTKFIFNICALLTL TITNSNESESISFIKVQFRQHSWEKFERSLYGI FIDT*EDELEMFAFFTLQIFL**TWELEVKFVDG IASFA*RVYFFSKYIFL*PTIKSVSEYNECN*H NN*KSLTIPKIVLYN*ITLHPIWKFFQGYLKFT KM*SIIISFKDSQFHCAQCSCEMTVLSSDSVSRN *VNLLEMKRNNICVSAVDVPPARK*RSEIYNVW HPLEITFPTLKRKKRKSRILH*CCLMQSTLMLG RIHSFSTFHSLRKLLVSICNLLGTVPESTHFYSH KENPHKVRIVVTTFN*A*KTASSREWDN*ASLG QWSPSTGHTLESANATLIANLWI*EREQLIAQT RS*NHKKNLCICNSK*HSRTLATSRVVSELCKWT *QGKIVGFFSLIQPRKCLFLPYT*F*TFLATNI SLFAPTPGKTKYIIDLFIKFRRKKKFSLTFSSI GFISI*LHHVLCLGKHSISCLGGHPVCVPVQYTL IIKTSKCF*AIKSWESPI*HLNNYFSKFVIINS FNLISLNQFCIVILLFSGKQPIVQLLNQNFQRL TSLTWACTYLS*VILYPLNL*VPLFYYLPHSSYL NMFVFPVECDFYLLFILSFIPMSIIS*SFQVPH HQRDDHNFTFF*NEVLLCCPGWSAVAQSQLTTT SASQVQAILP*PPK*LELQVPATMSG*FLCF**R WGFTMLARLVLNS*P*VIHPPQPPKVLGLQE*A TAPGQFTFKY*KAHSTQTFSGQFSLGGSLINFV ITSRKKAQNDM*K*Y*TIYQMSSNIKIDLTCYPS HADSLALLFKDPVSYVKHFPYLLQ*YYWPYTKF SFT*LSKNSLRLES*NHKATRSAQQQW*YLSPN SETL*SFSLQT*ARPNLTW*KSIGNKLLVYDSSS RAFWVPFH*GNENITD*PRQSGNKE*LILLQVA VSKPSSLPHS*RVEGENAVLIFCPAIFNLKFRI TSGIQRMFPIKGKSVNDDCKKQVK*CKEKIFAKQ NLTRHHHEDKMASLLCGLGVLGQSCHTFLLGHV ALLRIHSMLARWFN*LNN*INLFCFLN*PDI*L NVLGLAF*THCLRFL*CMMTLKMFGHFS*NAG*H LMQP**QEKSVLF*KCF*Q*KYFWLREYS*LVG RLPRNKCMQHK*GILFFKRLSI*DTLIK*RNCW *ML*K

Frame 2

SMNSC*VENGG*ILHGDSYLLDLQELRRVSDCP CPETTVSFQK*ESGRGLMQQDHPEPAVDVD*G* KAPSC*ICTVLGHLQLFPRPLPLSHLGPLFPGT PMDLL*SGRLP*GGKCLSLSPETRLQSSGQEGQE IPP*LDENRCQQGGKTGQ*KPLFTKSWPGSRSF GEEH*KHGSTPDSHYL*CSSRWPGIPY*EYHRG LHQKCCRKLQPKQQREAASQSAHDWNYRHIMGFV DYSALLQHH*RDWTGGAREM*LHPGGVQGLQPF CVYPVENFGLTL*L*PHL*Q*HPGGRVVPYLSD RQHHIRM*PSRFTSRNHL*LQDYFSG*RENSGLA NRSFTSC*VWSQ*REDDFNQLACLVDSFFRKSH LI*GAII**K*PKDTGGSNSRKYFME*IHFFQS HCW**IQYCHHSCFWRKTFFFSLYQWINSAISSE RYWYFHKSQFSPDFLVPWFWECGTIPADANG*R DPSSWRCCGQTCYFLCFSRADPWLPLQPHCYD* GCRAAKLQVETSQDSPHGSLKSEGDK*WQFDLSK SQMAKTSWKCGFLQYHPVSQRDHQGIQSISTLD Y*NSL*RVSPRSTLSSYCQLCLW*TVCSEDGSG QNISRQSCKPGGKQ*WQDEVSCSELVAPCWRLGA VSDPTLQ*FCGAAQHHCGKGRNTVCHG*HGART GKTV*GGSHC*EWKFEEF*ALPRQDSPPGCPPA SCQTCQ*NLTEYHVADPCSRMGEIHHFPS*QRPL TDPQVTLQRCQRIHFY*PGAWTKIHGYSHQY*W RLKKFLFSKRKNSACPSD*LACGQPRNDQ*SVY *LDPGTRRRRILPSLTDP*KCGH*K*KHLQ*DQQ IQLPLSQVRQPVLRGGNNSEWRDLFPTSGCGGK NSPFQCEWSNGEQFRS**LPQRFLAAGARRCG* L*GNIVS*RQGGSVPCHCQVCQRMFLQLPHPRPP LHRDHNYKEWQV*KSLLQPRADSA*QSPGSQC* QLSQE*LFKGILGACHWRL*SL*SHH*KQKQLH SN*KHSQVRKRMCICSASPWTVVQCHCYYKKWTI *SQ*TREWENNSRAC*GSNIAQQEH*GLACDLV RS*WGCRPI*DPAALQ*HESISSFSPCKYRNRV SIYFPNTRPPIQNSCLDD*RGCTAVSLH*GLHSS *CCQKYSHFSQWSNR*PDGELDSWWGRR*FLHG VGIQAQSKG*LSDYSQARL*AHVPQTGGRGAVP DHDCLSQRVPEESDKCGWADSSSICPRSNCRQCI QQLFLNSKLAKSCWCGRKI*YPASN*KWNPSAQ HIRASHH*ATQI*RSNTRQEIQDTDPNCQWRPL *QGSPD*RPNSPSSCHRPEDHRELHQAPVLPLDR LRGGAQLVQHLFVQPRWESPGESSS*PTSPELL FPELATRQNVQDGDCNSQWGAV**VFHIW*NSP SLCESSQGVQSEHDRQPLVQLESSLWGL*LL*AD SL*SQWHKEGKLERQGPDGVAVSRPCSWKEVRA VGGNSQWRSQQ*SHSGEQNSSKSSQSYVIC*HC KHILGHHVERAPRLDRLQRL*AAVVAQRCTYCLQ PLQQQKIRRTHCVWSSSREILSIQRQDCQW*FL ENLQQTNFWICEDKA*QDTKPALPASELHGHCL FLDPS*F*L*WL*Y*MPENGHPRS*VFQKAGERK ISAQHHDASAP*EVPGVHQSAVGRHDQRGG*RQ HYHNDRPPPSSTPTHSCE*KGCAN*QVFHQLYC QLQLVQRHQWSCEILHSGGERG*WQ**AEARTAA PSPFLPGVQAQCLHSGVSD*LFCQQMCRKS*QQ LQEF*H*AWSRDGEPRWKMRSHSAKIL*WTTEA THCLQNQHSSFYTAL**GPEGIHKATLFRHIFFF THHY*IRALVWSY*RCECWSVFNWHASGCCCLI DLQTESEPWSRKTLCPSEHS*GSTIICPLKPGP ER*PENFLSNKNKSV*RAFHEATG*LQLPSIQGI RGVKRRGPKPVM*HCTLAGE*REKSIQQYIAL* CHASEALQCR**SLL*LHQCQLHPWQQLQKRIH CHSGTASWHQG*LLENGVGTKRSQHRHGDPVC*E GPSKV*SLLASGPGFPLLWGPHPADALRVRPA* VDHPGV*DMR*GTA*CTQTHPPLSLYGVARPWS PRNHPVSDPVCENCQGLHQQKPGCWAHCGALQCW CG*DWNLYCIGPNPPAVRLQRLCGHLWSSARPK TSQGSHGPD*VSVCLPTSVCKRCPQSKKATE*T RKPLVSNL*KCESRVSQRSSLFKALRMYLKSSWI KIIHCVICF*KLASCPTEVPAISVDTMYNLLIW RMFKILYNLKVTDIIVHSCIL*FLL*ICIFHNV *Y*ALYNTIFPH*SVHDLFYIKLIQPV*QDYW*N AYGGGGRDNPSGHVFYLF*YSLDRKKGRARESK YYG*ICCIAVP*ISRANRHVLTCY*DKCDSQKK D*REGEKRIKQYQS*TRCLCLN*LLSLSFLLPGI QAKVVSSGIM*LAVQAQDGRMQG*GF**RMIPN RSDEFLLLIRCQLYPDWKHNMQSTIYSD*RSFH CIHGVECEHPHPYCNVFIHTSFCLIFSGLHS*KS HNYPFLLDFPLKEYYGSRLCPSLKGLMPTFS*K *LQTSYIVNLKTIAKTKTVVFSKIFKTSFSKSM KSKCQVITQSCI**QKALHTVPSLSSIFVPYLL* L*QIPMSQKVFPSSRSSSDSIPGKNLKGVCTES S*IPEKMSWRCLPFSHYKFFCNKLGN*RSSLLM A*LPLHKEYISFQSIYFCNLP*SP*VNTTNVIDI IIENH*LYLK*FFIIK*LYTQSGNFSKVI*SLQ KCEA*S*ASKIHSFIVLNALVK*QS*ALILYQG TK*IFWK*KGTTYV*VQ*MYHQRENRGQRSTTCG IH*KSPFLH*KEKREKAEFYTNVA*CKAH*CLE GYIHFRLFIHSENF**VSATC*ALFQNLHISTH IKRILIKLGLLLLPSIELKRQPHQGNGITEPV*D SGHLPQATHWKVLMLL**QTSGSRRESN*LHKP GVKTIKKTYASVIVNNTHVLWQHLG*YQNYVNG HDREKS*VFLV*SNPGNVYSYPTPNFKPS*QQIF HYSLLLLGRLNI*LTYLLNLGEKKSFP*HSALL DLFPFNCIMCYVLVNTPFPVLVGILSVYLCSTL *SSRLQSAFELSNLGRVPSSILIIIFPSSL*LTP LTSSH*INFVLSFCCSLESSQLFSS*IRIFKDS PLLPGLAHICPK*FSIP*TSESLCFITCPTPPT *ICLFSQLNVIFIYCSYYLLYP*V*FHSPFRFHI IKEMTIISLFFEMKSCSVAQAGVQWHNLSSLQP PPPRFKRFCLSLPSSWNYRCLPPCLANFCVFSR DGVSPCWPGWS*TRDLR*STHLNLPKC*DYKSEP PHLANSLLNTKRHTAHRHFRGSFLWEGL**IL* SPLGRKPKMTCENNIKPFTRCPAI*K*TSHATL HMLILLPCCLRIQFLMLNIFLTFCNNIIGHILNS HSLSFLRIL*GWNPEIIKLPDLHNSSGSI*AQT LRRSRVLVYKHEPDQT*PGENQ*VINCLYMIAV QGLSGFHFTEEMKI*LISQDRVAIRNN*SSSKLQ *ASPQAYLIPEELKEKMPC*FSALLFLT*NLEL HQVFKECSLSKENL*TMTAKSK*NDAKRKYLQN RI*PDIIMKIKWHLFCVAWVCLDNPVTRFY*DML PF*GFTLCWPDGLTD*TIESIYFAF*IDQIFN* MYWVWHFRHTALDSCSA**L*KCLAILVKMQGN I*CSHDNRKNLFCSKNVSSNRSISG*ENTLDL*G GSLGINVCNTNKAFYFLKDCLYKIHLLNKEIVG ECSE

Sequence PTPRB.cAug05

GTCTCCTCTGGATCTTAACTACTGAGCGCAATGCTGAGCCATGGAGCCGGGTTGGCCTTGTGGATCACACTGAGCCTGCTGCAGACTGGACTGGCGGAGC CAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCTATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCAT CTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACCTTTCGGATAGACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATC TATAACTTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAGACGA CTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACCTCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGT TCAAATTCAAGAAAGTACTTCATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTCTGGAGGAAAA CGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGAAAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCC ATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGGGATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTT TCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCCCCCATG GAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGACCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCC TGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAAACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTAC TGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCAGAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGG ATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGAGACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATCACTG TGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGACAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAA TTCTGAGCGTTGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCT GTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCTTACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTTACTG ACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGGAGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGT GACTGACTTGCATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTAGAATTTTACCAAGTCTTACTGATC CATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCAGATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAA CAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGTAA TGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAACATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATT GCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTCACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCT TCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCAGCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGG AGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAACAACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTA GTCCCTGGACGGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTTAAGG ATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCAGGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGA CATGAAAGTATTTCCTCCTTTTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCTTGTCTTGACG ATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCC TGACGGTGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCA CGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGCGGGTCCCTGAAGAATCAGATAAATGTGGTT GGGCGGACAGTTCCAGCATCTGTCCAAGGAGTAATTGCAGACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTGGCAG AAAGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCAGAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACC AGGCAAGAAATACAAGATACAGATCCTAACTGTCAGTGGAGGCCTCTTTAGCAAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCACCGAC CTGAGGATCACAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCAGATG GGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCA CAGTGGGGAGCTGTCTAATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGACAGACAGCCTT TGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACC TGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAG CAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACGTGGAAAGGGCCCCCAGACTGGACAGACTAC AACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTACTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTC CAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCAATTTTTGGATCTGTGAGGACAAAGCCTGACAA GATACAAAACCTGCATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGTTCTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGG AAAATGGACACCCAAGAAGTTGAGTTTTCCAGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTGGTGT CCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATCACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGT GAATGAAAAGGATGTGCTAATTAGCAAGTCTTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTG GTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCTCCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGGGTGT ATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCCTAACAGCAACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGG AAAATGCGATCCCACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGAGCTTTTACACAGCTCTTTGATGAG GACCTGAAGGAATTCACAAAGCCACTCTATTCAGACACATTTTTTTCTTTACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGA GTGCTGGTCTGTTTTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCT GAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGG CATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCT TGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTA CATCAATGCCAGCTACATCCCTGGCAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTG TGGGAACAAAACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCT ACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACA CAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGTCAGGGACTAC ATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGT TAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACA TCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGA GATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCCTGGATAAAAATTATTCACTGTGTGATTTGTTTTTAAAAACTTGCTTCATGCCCTAC AGAGGTGCCAGCTATTTCTGTTGATACTATGTATAATTTATTAATCTGGAGAATGTTTAAAATTTTATATAATTTAAAGGTAACAGATATTATTGTACAT AGTTGTATTTTGTAGTTTCTTCTGTAAATATGTATTTTTCATAATGTTTAATATTAAGCTTTATATAATACTATTTTTCCACACTAAAGTGTTCATGACT TGTTCTACATAAAACTAATTCAACCTGTATGACAGGACTACTGGTAAAATGCATATGGAGGTGGTGGCAGAGACAATCCTTCAGGCCATGTTTTCTACCT GTTTTGATATTCACTGGACAGGAAAAAGGGCAGGGCTAGAGAGAGCAAATACTATGGCTAGATTTGCTGCATTGCTGTCCCATGAATCTCGAGAGCCAAC AGACATGTCCTAACTTGCTATTAGGACAAATGTGACAGTCAAAAAAAGGATTAGAGGGAGGGAGAAAAAAGAATTAAGCAGTACCAAAGCTGAACTAGAT GCTTGTGTCTGAACTAGTTGCTCTCTCTCTCCTTTCTCCTTCCAGGGATTCAAGCCAAAGTGGTCAGCTCAGGGATCATGTAACTTGCAGTGCAAGCCCA GGATGGTAGGATGCAGGGTTGAGGGTTCTGATAGAGAATGATTCCAAACAGAAGTGATGAATTCCTTTTGTTAATAAGATGCCAGCTATACCCAGACTGG AAACATAACATGCAAAGCACTATCTACAGTGATTAGAGATCCTTTCATTGCATTCATGGTGTGGAGTGTGAACATCCACACCCATACTGTAATGTATTTA TACACACTAGTTTCTGTCTCATTTTCAGTGGTCTCCATTCCTAGAAAAGTCACAATTATCCATTCCTACTTGATTTCCCATTAAAAGAATATTATGGTAG CAGATTGTGCCCCTCATTAAAAGGCTTAATGCCAACATTTTCATAGAAATGACTACAAACATCATATATAGTAAATTTAAAAACAATAGCAAAAACAAAA ACAGTGGTCTTCAGTAAAATTTTCAAAACTTCTTTTAGTAAATCAATGAAGTCAAAATGTCAAGTAATCACCCAAAGTTGCATTTAATAACAAAAGGCAC TACATACTGTACCAAGTTTATCTTCAATATTTGTGCCTTACTTACTTTGACTATAACAAATTCCAATGAGTCAGAAAGTATTTCCTTCATCAAGGTCCAG TTCCGACAGCATTCCTGGGAAAAATTTGAAAGGAGTTTGTACGGAATCTTCATAGATACCTGAGAAGATGAGCTGGAGATGTTTGCCTTTTTCACACTAC AAATTTTTCTGTAATAAACTTGGGAATTAGAGGTCAAGTTTGTTGATGGCATAGCTTCCTTTGCATAAAGAGTATATTTCTTTTCAAAGTATATATTTTT GTAACCTACCATAAAGTCCGTAAGTGAATACAACGAATGTAATTGACATAATAATTGAAAATCATTGACTATACCTAAAATAGTTCTTTATAATTAAATA ACTCTACACCCAATCTGGAAATTTTTCCAAGGTTATTTGAAGTTTACAAAAATGTGAAGCATAATCATAAGCTTCAAAGATTCACAGTTTCATTGTGCTC AATGCTCTTGTGAAATGACAGTCTTAAGCTCTGATTCTGTATCAAGGAACTAAGTGAATCTTCTGGAAATGAAAAGGAACAACATATGTGTAAGTGCAGT AGATGTACCACCAGCGAGAAAATAGAGGTCAGAGATCTACAACGTGTGGCATCCATTAGAAATCACCTTTCCTACATTGAAAAGAAAAAAGAGAAAAAGC AGAATTTTACACTAATGTTGCTTGATGCAAAGCACATTAATGCTTGGAAGGATACATTCATTTTCGACTTTTCATTCACTCAGAAAACTTCTAGTAAGTA TCTGCAACCTGCTAGGCACTGTTCCAGAATCTACACATTTCTACTCACATAAAGAGAATCCTCATAAAGTTAGGATTGTTGTTACTACCTTCAATTGAGC TTAAAAGACAGCCTCATCAAGGGAATGGGATAACTGAGCCAGTCTAGGACAGTGGTCACCTTCCACAGGCCACACACTGGAAAGTGCTAATGCTACTTTA ATAGCAAACCTCTGGATCTAGGAGAGAGAGCAATTAATTGCACAAACCAGGAGTTAAAACCATAAAAAAAACCTATGCATCTGTAATAGTAAATAACACT CACGTACTCTGGCAACATCTAGGGTAGTATCAGAATTATGTAAATGGACATGACAGGGAAAAATCGTAGGTTTTTTTAGTCTAATCCAACCCAGGAAATG TTTATTCCTACCCTACACCTAATTTTAAACCTTCTTAGCAACAAATATTTCACTATTCGCTCCTACTCCTGGGAAGACTAAATATATAATTGACTTATTT ATTAAATTTAGGAGAAAAAAAAAGTTTTCCTTGACATTCAGCTCTATTGGATTTATTTCCATTTAATTGCATCATGTGTTATGTCTTGGTAAACACTCCA TTTCCTGTCTTGGTGGGCATCCTGTCTGTGTACCTGTGCAGTACACTTTAATCATCAAGACTTCAAAGTGCTTTTGAGCTATCAAATCTTGGGAGAGTCC CATCTAGCATCTTAATAATTATTTTTCCAAGTTCGTTATAATTAACTCCTTTAACCTCATCTCATTAAATCAATTTTGTATTGTCATTCTGTTGTTCTCT GGAAAGCAGCCAATTGTTCAGCTCTTGAATCAGAATTTTCAAAGACTCACCTCTCTTACCTGGGCTTGCACATATTTGTCCTAAGTAATTCTCTATCCCT TAAACCTCTGAGTCCCTCTGTTTTATTACTTGCCCCACTCCTCCTACTTGAATATGTTTGTTTTCCCAGTTGAATGTGATTTTTATCTACTGTTCATATT ATCTTTTATACCCATGAGTATAATTTCATAGTCCTTTCAGGTTCCACATCATCAAAGAGATGACCATAATTTCACTTTTTTTTGAAATGAAGTCTTGCTC TGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCTGCCTTAGCCTCCCAAGTAGCTGGAAT TACAGGTGCCTGCCACCATGTCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCGTGACCTTAGGT GATCCACCCACCTCAACCTCCCAAAGTGCTAGGATTACAAGAGTGAGCCACCGCACCTGGCCAATTCACTTTTAAATACTAAAAGGCACACAGCACACAG ACATTTTCGGGGCAGTTTTCTTTGGGAGGGTCTTTGATAAATTTTGTAATCACCTCTCGGAAGAAAGCCCAAAATGACATGTGAAAATAATATTAAACCA TTTACCAGATGTCCAGCAATATAAAAATAGACCTCACATGCTACCCTTCACATGCTGATTCTCTTGCCTTGCTGTTTAAGGATCCAGTTTCTTATGTTAA ACATTTTCCTTACCTTTTGCAATAATATTATTGGCCATATACTAAATTCTCATTCACTTAGCTTTCTAAGAATTCTTTGAGGTTGGAATCCTGAAATCAT AAAGCTACCAGATCTGCACAACAGCAGTGGTAGTATCTGAGCCCAAACTCTGAGACGCTCTAGAGTTTTAGTTTACAAACATGAGCCAGACCAAACCTGA CCTGGTGAAAATCAATAGGTAATAAACTGCTTGTATATGATAGCAGTTCAAGGGCTTTCTGGGTTCCATTTCACTGAGGAAATGAAAATATAACTGATTA GCCAAGACAGAGTGGCAATAAGGAATAACTGATCCTCCTCCAAGTTGCAGTGAGCAAGCCCTCAAGCCTACCTCATTCCTGAAGAGTTGAAGGAGAAAAT GCCGTGCTAATTTTCTGCCCTGCTATTTTTAACCTGAAATTTAGAATTACATCAGGTATTCAAAGAATGTTCCCTATCAAAGGAAAATCTGTAAACGATG ACTGCAAAAAGCAAGTGAAATGATGCAAAGAGAAAATATTTGCAAAACAGAATCTAACCAGACATCATCATGAAGATAAAATGGCATCTCTTCTGTGTGG CCTGGGTGTGCTTGGACAATCCTGTCACACGTTTCTATTAGGACATGTTGCCCTTTTGAGGATTCACTCTATGTTGGCCAGATGGTTTAACTGATTAAAC AATTGAATCAATTTATTTTGCTTTTTGAATTGACCAGATATTTAACTAAATGTACTGGGTTTGGCATTTTAGACACACTGCCTTAGATTCTTGTAGTGCA TGATGACTTTGAAAATGTTTGGCCATTTTAGTTAAAATGCAGGGTAACATTTGATGCAGCCATGATAACAGGAAAAATCTGTTCTGTTCTAAAAATGTTT CTAGCAATAGAAGTATTTCTGGCTAAGAGAATACTCTTGACTTGTAGGGAGGCTCCCTCGGAATAAATGTATGCAACACAAATAAGGCATTTTATTTTTT AAAAGATTGTCTATATAAGATACACTTATTAAATAAAGAAATTGTTGGTGAATGCTCTGAAAA

PTPRB.F6 (forward primer)
PTPRB.R6 (reverse primer)
Single exon skipping

Frame 0

VSSGS*LLSAMLSHGAGLALWITLSLLQTGLAE PERCNFTLAESKASSHSVSIQWRILGSPCNFSLI YSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI YNFRIISLDEERTVVLQTDPLPPARFGVSKEKT TSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGV QIQESTSWNEYTFFNLTAGSKYNIAITAVSGGK RSFSVYTNGSTVPSPVKDIGISTKANSLLISWS HGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPM EVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNIT LSHKGTIKESRVLAPWITETHFKELVPGRLYQVT VSCVSGELSAQKMAVGRTFPDKVANLEANNNGR MRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT VGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKN SERCQGRTVPLAVLQLRVKHANETSLSIMWQTP VAEWEKYIISLADRDLLLIHKSLSKDAKEFTFT DLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLI HENVVIKNESISSETSRYSFHSLKSGSLYSVVV TTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRN DYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVI AKSVRECSFSSLTPGRLYTVTITTRSGKYENHS FSQERTVPDKVQGVSVSNSARSDYLRVSWVHATG DFDHYEVTIKNKNNFIQTKSIPKSENECVFVQL VPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVK DLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLT ISGDVQQSAFIEGFTVPSAVKNIHISPNGATDS LTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKH VFEHTFHRLEAGEQYQIMIASVSGSLKNQINVV GRTVPASVQGVIADNAYSSYSLIVSWQKAAGVA ERYDILLLTENGILLRNTSEPATTKQHKFEDLTP GKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTD LRITENSTRHLSFRWTASEGELSWYNIFLYNPD GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH SGELSNESFIFGRTVPASVSHLRGSNRNTTDSL WFNWSPASGDFDFYELILYNPNGTKKENWKDKD LTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAES RTAPSPPSLMSFADIANTSLAITWKGPPDWTDY NDFELQWLPRDALTVFNPYNNRKSEGRIVYGLR PGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDK IQNLHCRPQNSTAIACSWIPPDSDFDGYSIECR KMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLV SIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTV VVREADGSDELKPEQQHPLPSYLEYRHNASIRV YQTNYFASKCAENPNSNSKSFNIKLGAEMESLGG KCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDE DLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV SAGLFLIGMLVAVVALLICRQKVSHGRERPSARL SIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEG HFMKLQADSNYLLSKEYEELKDVGRNQSCDIAL LPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY INASYIPGNNFRREYIVTQGPLPGTKDDFWKMV WEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSL YYGDLILQMLSESVLPEWTIREFKICGEEQLDAH RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDY INRSPGAGPTVVHCSAGVGRTGTFIALDRILQQ LDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLH QCVRDVLRARKLRSEQENPLFPIYENVNPEYHR DPVYSRH*ECT*RAPG*KLFTV*FVFKNLLHAL QRCQLFLLILCIIY*SGECLKFYII*R*QILLYI VVFCSFFCKYVFFIMFNIKLYIILFFHTKVFMT CST*N*FNLYDRTTGKMHMEVVAETILQAMFST CFDIHWTGKRAGLERANTMARFAALLSHESREPT DMS*LAIRTNVTVKKRIRGREKKELSSTKAELD ACV*TSCSLSPFSFQGFKPKWSAQGSCNLQCKP RMVGCRVEGSDRE*FQTEVMNSFC**DASYTQTG NITCKALSTVIRDPFIAFMVWSVNIHTHTVMYL YTLVSVSFSVVSIPRKVTIIHSYLISH*KNIMV ADCAPH*KA*CQHFHRNDYKHHI**I*KQ*QKQK QWSSVKFSKLLLVNQ*SQNVK*SPKVAFNNKRH YILYQVYLQYLCLTYFDYNKFQ*VRKYFLHQGP VPTAFLGKI*KEFVRNLHRYLRR*AGDVCLFHTT NFSVINLGIRGQVC*WHSFLCIKSIFLFKVYIF VTYHKVRK*IQRM*LT**LKIIDYT*NSSL*LN NSTPNLEIFPRLFEVYKNVKHNHKLQRFTVSLCS MLL*NDSLKL*FCIKELSESSGNEKEQHMCKCS RCTTSEKIEVRDLQRVASIRNHLSYIEKKKEKK QNFTLMLLDAKHINAWKDTFIFDFSFTQKTSSKY LQPARHCSRIYTFLLT*RESS*S*DCCYYLQLS LKDSLIKGMG*LSQSRTVVTFHRPHTGKC*CYF NSKPLDLGERAINCTNQELKP*KKPMHL***ITL TYSGNI*GSIRIM*MDMTGKNRRFF*SNPTQEM FIPTLHLILNLLSNKYFTIRSYSWED*IYN*LI Y*I*EKKKVFLDIQLYWIYFHLIASCVMSW*TLH FLSWWASCLCTCAVHFNHQDFKVLLSYQILGES HLAS**LFFQVRYN*LL*PHLIKSILYCHSVVL WKAANCSALESEFSKTHLSYLGLHIFVLSNSLSL KPLSPSVLLLAPLLLLEYVCFPS*M*FLSTVHI IFYTHEYNFIVLSGSTSSKR*P*FHFFLK*SLA LLPRLECSGTISAHYNLRLPGSSDSALASQVAGI TGACHHVWLIFVFLVEMGFHHVGQAGLELVTLG DPPTSTSQSARITRVSHRTWPIHF*ILKGTQHT DIFGAVFFGRVFDKFCNHLSEESPK*HVKIILNH LPDVQQYKNRPHMLPFTC*FSCLAV*GSSFLC* TFSLPFAIILLAIY*ILIHLAF*EFFEVGILKS *SYQICTTAVVVSEPKL*DALEF*FTNMSQTKPD LVKINR**TACI**QFKGFLGSISLRK*KYN*L AKTEWQ*GITDPPPSCSEQALKPTSFLKS*RRK CRANFLPCYF*PEI*NYIRYSKNVPYQRKICKR* LQKASEMMQRENICKTESNQTSS*R*NGISSVW PGCAWTILSHVSIRTCCPFEDSLYVGQMV*LIK QLNQFILLFELTRYLTKCTGFGILDTLP*ILVVH DDFENVWPF*LKCRVTFDAAMITGKICSVLKMF LAIEVFLAKRILLTCREAPSE*MYATQIRHFIF *KIVYIRYTY*IKKLLVNALK

Frame 1

SPLDLNY*AQC*AMEPGWPCGSH*ACCRLDWRS QRDVTSPWRSPRPPAILCLSSGEFWAHPVTLAS SIAVTPWGPRCALPFG*TTPHTDVTFKIYKQEPS ITSGLFLWMKREQWSCKQILYLLLGLESVKRRR LQPACMFGGLLLPEKSPHMRCNYLMKITKRYRG FKFKKVLHGMNTLFSISLLVVNTILPSQLFLEEN VLFQFIPMDQQCHLQ*KILVFPQKPILS*FPGP MVLGMWNDTG*C*WIKGS*FMAVLWTNMLLPML FTG*PLATSTTSLL*LRLQGCKTTGGN*SGQPPW KSQI*R*QMMAV*PL*KSNGKDLLEMWILTISP CLTKGPSRNPEY*HLGLLKLTLKS*SPVDFIKL LSAVSLVNCLLRRWQWAEHFQTKLQTWRQTIMAG *GLL**AGRPLLETGSSIGSYSSMILWCCSTSL WERKKHSMSWMTRGSYREDSMRWKSLLRVEI*R ILSVAKAGQSPWLSSSFVSNMPMKPH*VSCGRPL *QNGRNTSFP*LTETSY*STSHSPKMPKNSLLL TWCLDENTWLQSPVLVET*KIPLQ*KEEQCLPK *LTCMWPTKE*PVVCLLTGPRHKET*NFTKSY*S MKMWSLKMKASPVRPADTASTLSSPAACTPWW* QQ*VEGSLPDKWLWREEQSLPV*VE*R*TIPVV MTTSAFPGCWRPEMWITMR*HCLMTARWFSPLSL PSLSENVPSAPSPQAASTP*P*LQGVASMKITP SAKSGQCLTKSRESVLATQPGVTI*GYPGCMPL ETLITMKSPLKTKTTSFKLKAFPSQKTNVYLFS* SLDGCTVSLLLQKVDNMKPMNKGMGEQFQSLLR I*HCATGALRTCM*LGQELMGMSTNMRSSCSSM T*KYFLLFTL*IPQPSIDLLP*HQAANTKFLS*R LAGMYSSQPSLRASQFLVLSKIFTFLPMEQQIA *R*TGLLVGETLIPTRCRHSGTVKRLTLRLFPS TSLSTRSTDWRPGSSTRS*LPQSAGP*RIR*MWL GGQFQHLSKE*LQTMHTAVIP***VGKKLLVWQ KDMISCF*LKMESFCATHQSQPPLSNTNLKI*H QARNTRYRS*LSVEASLARKPRLKAEQSQQLSPT *GSQRTPPGTCPSAGPPQRGSSAGTTSFCTTQM GISRRELKLTH*SRASLSRTCYKAECTRW*L*L TVGSCLMSLSYLVEQSQPL*VISGGPIGTRQTAF GSTGVQPLGTLTFMS*FSIIPMAQRRKTGKTRT *RSGGFKALFLEGSTCCGW*LTVEISAIKSQRR AEQLQVLPVLCHLLTLQTHPWPSRGKGPQTGQTT TTLSCSGCPEMHLLSSTPTTTENQKDALCMVFV QGDPINSTSRLSVVIPGKLTANQFLDL*GQSLT RYKTCIAGLRTPRPLPVLGSLLILTLMVIVLNAG KWTPKKLSFPESWRKKNLCSTS*C*CPIRGTWC PSKCSRPA*PARWLKTALSQ**TAPLLHPHTFV *MKRMC*LASLPSTLLSTAAGSATPMEL*NTSQW W*ERLMAVMS*SQNSSTLSLPTWSTGTMPPFGC IRLIILPANVPKILTATPRVLTLSLEQRWRA*V ENAIPLSKNSVMDH*SHTLPTESAFELLHSSLMR T*RNSQSHSIQTHFFLYPSLLNQSPCLELLKV* VLVCF*LAC*WLLLPY*SADRK*AMVEKDPLPV *AFVGIDHYLST*TWARKVTGKLLVQ*K*ISLKG IS*SYRLTPTTFYPRNTRS*KTWAETSHVTLHS CRRIEGKIDTTIYCPMMPRE*SSPM*MMILALT TSMPATSLATTSEENTLSLRDRFLAPRMTSGKWC GNKTFTTSSW*PSVLRRAE*SVIITGQRTRIPS TMGTSSCRCSQSPSCLSGPSGSLRYAVRNSLMH TDSSATFTIRCGQTMESQKPPSL*SSL*ELSGTT STEARVLGPLWCTAVLVWVGLEPLLHWTESSSS *TPKTLWTFMEQCTT*DFTGFTWSRLSVSMSTY ISV*EMSSEQESYGVNKKTPCFQSMKM*IQSITE IQSIQGIENVPEELLDKNYSLCDLFLKTCFMPY RGASYFC*YYV*FINLENV*NFI*FKGNRYYCT *LYFVVSSVNMYFS*CLILSFI*YYFSTLKCS*L VLHKTNSTCMTGLLVKCIWRWWQRQSFRPCFLP VLIFTGQEKGQG*REQILWLDLLHCCPMNLESQ QTCPNLLLGQM*QSKKGLEGGRKKN*AVPKLN*M LVSELVALSLLSPSRDSSQSGQLRDHVTCSASP GW*DAGLRVLIENDSKQK**IPFVNKMPAIPRL ET*HAKHYLQ*LEILSLHSWCGV*TSTPIL*CIY TH*FLSHFQWSPFLEKSQLSIPT*FPIKRILW* QIVPLIKRLNANIFIEMTTNIIYSKFKNNSKNK NSGLQ*NFQNFF**INEVKMSSNHPKLHLITKGT TYCTKFIFNICALLTLTITNSNESESISFIKVQ FRQHSWEKFERSLYGIFIDT*EDELEMFAFFTL QIFL**TWELEVKFVDGIASFA*RVYFFSKYIFL *PTIKSVSEYNECN*HNN*KSLTIPKIVLYN*I TLHPIWKFFQGYLKFTKM*SIIISFKDSQFHCA QCSCEMTVLSSDSVSRN*VNLLEMKRNNICVSAV DVPPARK*RSEIYNVWHPLEITFPTLKRKKRKS RILH*CCLMQSTLMLGRIHSFSTFHSLRKLLVS ICNLLGTVPESTHFYSHKENPHKVRIVVTTFN*A *KTASSREWDN*ASLGQWSPSTGHTLESANATL IANLWI*EREQLIAQTRS*NHKKNLCICNSK*H SRTLATSRVVSELCKWT*QGKIVGFFSLIQPRKC LFLPYT*F*TFLATNISLFAPTPGKTKYIIDLF IKFRRKKKFSLTFSSIGFISI*LHHVLCLGKHS ISCLGGHPVCVPVQYTLIIKTSKCF*AIKSWESP I*HLNNYFSKFVIINSFNLISLNQFCIVILLFS GKQPIVQLLNQNFQRLTSLTWACTYLS*VILYP LNL*VPLFYYLPHSSYLNMFVFPVECDFYLLFIL SFIPMSIIS*SFQVPHHQRDDHNFTFF*NEVLL CCPGWSAVAQSQLTTTSASQVQAILP*PPK*LE LQVPATMSG*FLCF**RWGFTMLARLVLNS*P*V IHPPQPPKVLGLQE*ATAPGQFTFKY*KAHSTQ TFSGQFSLGGSLINFVITSRKKAQNDM*K*Y*T IYQMSSNIKIDLTCYPSHADSLALLFKDPVSYVK HFPYLLQ*YYWPYTKFSFT*LSKNSLRLES*NH KATRSAQQQW*YLSPNSETL*SFSLQT*ARPNL TW*KSIGNKLLVYDSSSRAFWVPFH*GNENITD* PRQSGNKE*LILLQVAVSKPSSLPHS*RVEGEN AVLIFCPAIFNLKFRITSGIQRMFPIKGKSVND DCKKQVK*CKEKIFAKQNLTRHHHEDKMASLLCG LGVLGQSCHTFLLGHVALLRIHSMLARWFN*LN N*INLFCFLN*PDI*LNVLGLAF*THCLRFL*C MMTLKMFGHFS*NAG*HLMQP**QEKSVLF*KCF *Q*KYFWLREYS*LVGRLPRNKCMQHK*GILFF KRLSI*DTLIK*RNCW*ML*K

Frame 2

LLWILTTERNAEPWSRVGLVDHTEPAADWTGGA REM*LHPGGVQGLQPFCVYPVENFGLTL*L*PH L*Q*HPGGRVVPYLSDRQHHIRM*PSRFTSRNH L*LQDYFSG*RENSGLANRSFTSC*VWSQ*REDD FNQLACLVDSFFRKSHLI*GAII**K*PKDTGG SNSRKYFME*IHFFQSHCW**IQYCHHSCFWRK TFFFSLYQWINSAISSERYWYFHKSQFSPDFLVP WFWECGTIPADANG*RDPSSWRCCGQTCYFLCF SRADPWLPLQPHCYD*GCRAAKLQVETSQDSPH GSLKSEGDK*WQFDLSKSQMAKTSWKCGFLQYHP VSQRDHQGIQSISTLDY*NSL*RVSPRSTLSSY CQLCLW*TVCSEDGSGQNISRQSCKPGGKQ*WQ DEVSCSELVAPCWRLGAVSDPTLQ*FCGAAQHHC GKGRNTVCHG*HGARTGKTV*GGSHC*EWKFEE F*ALPRQDSPPGCPPASCQTCQ*NLTEYHVADP CSRMGEIHHFPS*QRPLTDPQVTLQRCQRIHFY* PGAWTKIHGYSHQY*WRLKKFLFSKRKNSACPS D*LACGQPRNDQ*SVY*LDPGTRRRRILPSLTD P*KCGH*K*KHLQ*DQQIQLPLSQVRQPVLRGGN NSEWRDLFPTSGCGGKNSPFQCEWSNGEQFRS* *LPQRFLAAGARRCG*L*GNIVS*RQGGSVPCH CQVCQRMFLQLPHPRPPLHRDHNYKEWQV*KSLL QPRADSA*QSPGSQC*QLSQE*LFKGILGACHW RL*SL*SHH*KQKQLHSN*KHSQVRKRMCICSA SPWTVVQCHCYYKKWTI*SQ*TREWENNSRAC*G SNIAQQEH*GLACDLVRS*WGCRPI*DPAALQ* HESISSFSPCKYRNRVSIYFPNTRPPIQNSCLD D*RGCTAVSLH*GLHSS*CCQKYSHFSQWSNR*P DGELDSWWGRR*FLHGVGIQAQSKG*LSDYSQA RL*AHVPQTGGRGAVPDHDCLSQRVPEESDKCG WADSSSICPRSNCRQCIQQLFLNSKLAKSCWCGR KI*YPASN*KWNPSAQHIRASHH*ATQI*RSNT RQEIQDTDPNCQWRPL*QGSPD*RPNSPSSCHR PEDHRELHQAPVLPLDRLRGGAQLVQHLFVQPRW ESPGESSS*PTSPELLFPELATRQNVQDGDCNS QWGAV**VFHIW*NSPSLCESSQGVQSEHDRQP LVQLESSLWGL*LL*ADSL*SQWHKEGKLERQGP DGVAVSRPCSWKEVRAVGGNSQWRSQQ*SHSGE QNSSKSSQSYVIC*HCKHILGHHVERAPRLDRL QRL*AAVVAQRCTYCLQPLQQQKIRRTHCVWSSS REILSIQRQDCQW*FLENLQQTNFWICEDKA*Q DTKPALPASELHGHCLFLDPS*F*L*WL*Y*MP ENGHPRS*VFQKAGERKISAQHHDASAP*EVPGV HQSAVGRHDQRGG*RQHYHNDRPPPSSTPTHSC E*KGCAN*QVFHQLYCQLQLVQRHQWSCEILHS GGERG*WQ**AEARTAAPSPFLPGVQAQCLHSGV SD*LFCQQMCRKS*QQLQEF*H*AWSRDGEPRW KMRSHSAKIL*WTTEATHCLQNQHSSFYTAL** GPEGIHKATLFRHIFFFTHHY*IRALVWSY*RCE CWSVFNWHASGCCCLIDLQTESEPWSRKTLCPS EHS*GSTIICPLKPGPER*PENFLSNKNKSV*R AFHEATG*LQLPSIQGIRGVKRRGPKPVM*HCTL AGE*REKSIQQYIAL*CHASEALQCR**SLL*L HQCQLHPWQQLQKRIHCHSGTASWHQG*LLENG VGTKRSQHRHGDPVC*EGPSKV*SLLASGPGFPL LWGPHPADALRVRPA*VDHPGV*DMR*GTA*CT QTHPPLSLYGVARPWSPRNHPVSDPVCENCQGL HQQKPGCWAHCGALQCWCG*DWNLYCIGPNPPAV RLQRLCGHLWSSARPKTSQGSHGPD*VSVCLPT SVCKRCPQSKKATE*TRKPLVSNL*KCESRVSQ RSSLFKALRMYLKSSWIKIIHCVICF*KLASCPT EVPAISVDTMYNLLIWRMFKILYNLKVTDIIVH SCIL*FLL*ICIFHNV*Y*ALYNTIFPH*SVHD LFYIKLIQPV*QDYW*NAYGGGGRDNPSGHVFYL F*YSLDRKKGRARESKYYG*ICCIAVP*ISRAN RHVLTCY*DKCDSQKKD*REGEKRIKQYQS*TR CLCLN*LLSLSFLLPGIQAKVVSSGIM*LAVQAQ DGRMQG*GF**RMIPNRSDEFLLLIRCQLYPDW KHNMQSTIYSD*RSFHCIHGVECEHPHPYCNVF IHTSFCLIFSGLHS*KSHNYPFLLDFPLKEYYGS RLCPSLKGLMPTFS*K*LQTSYIVNLKTIAKTK TVVFSKIFKTSFSKSMKSKCQVITQSCI**QKA LHTVPSLSSIFVPYLL*L*QIPMSQKVFPSSRSS SDSIPGKNLKGVCTESS*IPEKMSWRCLPFSHY KFFCNKLGN*RSSLLMA*LPLHKEYISFQSIYF CNLP*SP*VNTTNVIDIIIENH*LYLK*FFIIK* LYTQSGNFSKVI*SLQKCEA*S*ASKIHSFIVL NALVK*QS*ALILYQGTK*IFWK*KGTTYV*VQ *MYHQRENRGQRSTTCGIH*KSPFLH*KEKREKA EFYTNVA*CKAH*CLEGYIHFRLFIHSENF**V SATC*ALFQNLHISTHIKRILIKLGLLLLPSIE LKRQPHQGNGITEPV*DSGHLPQATHWKVLMLL* *QTSGSRRESN*LHKPGVKTIKKTYASVIVNNT HVLWQHLG*YQNYVNGHDREKS*VFLV*SNPGN VYSYPTPNFKPS*QQIFHYSLLLLGRLNI*LTYL LNLGEKKSFP*HSALLDLFPFNCIMCYVLVNTP FPVLVGILSVYLCSTL*SSRLQSAFELSNLGRV PSSILIIIFPSSL*LTPLTSSH*INFVLSFCCSL ESSQLFSS*IRIFKDSPLLPGLAHICPK*FSIP *TSESLCFITCPTPPT*ICLFSQLNVIFIYCSY YLLYP*V*FHSPFRFHIIKEMTIISLFFEMKSCS VAQAGVQWHNLSSLQPPPPRFKRFCLSLPSSWN YRCLPPCLANFCVFSRDGVSPCWPGWS*TRDLR *STHLNLPKC*DYKSEPPHLANSLLNTKRHTAHR HFRGSFLWEGL**IL*SPLGRKPKMTCENNIKP FTRCPAI*K*TSHATLHMLILLPCCLRIQFLML NIFLTFCNNIIGHILNSHSLSFLRIL*GWNPEII KLPDLHNSSGSI*AQTLRRSRVLVYKHEPDQT* PGENQ*VINCLYMIAVQGLSGFHFTEEMKI*LI SQDRVAIRNN*SSSKLQ*ASPQAYLIPEELKEKM PC*FSALLFLT*NLELHQVFKECSLSKENL*TM TAKSK*NDAKRKYLQNRI*PDIIMKIKWHLFCV AWVCLDNPVTRFY*DMLPF*GFTLCWPDGLTD*T IESIYFAF*IDQIFN*MYWVWHFRHTALDSCSA **L*KCLAILVKMQGNI*CSHDNRKNLFCSKNV SSNRSISG*ENTLDL*GGSLGINVCNTNKAFYFL KDCLYKIHLLNKEIVGECSE

Sequence PTPRB.dAug05

GAAGCATGAACAGTTGCTAAGTGGAAAATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGGGTTTCAGATTGTCCATG TCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTGGGCTCATGCAACAGGACCATCCAGAACCAGCAGTGGATGTGGACTGAGGATGAAAA GCTCCTTCATGTTAAATCTGCACTGTGCTTGGCCATCTCCAACTCTTCCCGCGGCCCCTCCCGCTCAGCCATCTTGGACCGCTGTTCCCAGGCACCCCGA TGGACCTGCTATGATCAGGAAGGCTTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGCTCCAGAGTAGTGGTCAAGAAGGCCAGGAAAT ACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAGGGAAAACTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTCGGT GAGGAGCACTAGAAACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGCCTGGTATTCCTTATTAGGAATACCACAGAGGCCTTC ATCAGAAATGCTGCAGAAAACTACAGCCAAAACAGCAGCGAGAGGCAGCATCCCAATCTGCACATGACTGGAATTACAGACACATCATGGGTTTTGTCGA CTACTCAGCCCTTCTCCAGCACCACTGAAGAGACTGGACTGGCGGAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGT GTCTATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACCTTTCGGATAGAC AACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAA CAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACCTC ATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTTCATGGAATGAATACACTTTTTTCAATCTCACT GCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGAAAG ATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGGGAT CCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAGGCT GCAGGGCTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGACCTCTCTAAAAG TCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTAC TGAAACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCAGA ACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGAGACTGGGAGCAGT ATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGG AAGACAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTTCGT GTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCTTAC TGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGGAGA CTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTGCATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAAC TGGACCCAGGCACAAGGAGACGTAGAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCAGAT ACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAGAAC AGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTAT GAGGTAACATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTCACCCCAGGCCGCCTCT ACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCTTCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAA CTCAGCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAACAACTTCATTCAA ACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATG AAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCAGG AGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCTTTTCACCTTGTAAATACCGCAACCGAGTATCGA TTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCTTGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTA GTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTC GGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATC ATGATTGCCTCAGTCAGCGGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAGCATCTGTCCAAGGAGTAATTGCAGACAATGCATACA GCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTGGCAGAAAGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACAC ATCAGAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATACAAGATACAGATCCTAACTGTCAGTGGAGGCCTCTTTAGC AAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCT CAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTT CCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCTAATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCC TCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGACAGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTC TCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTGTG GGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAAC ACATCCTTGGCCATCACGTGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTACTGTCTTCAACC CCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAA AACTTACAGCAAACCAATTTTTGGATCTGTGAGGACAAGTATGACATGTTTTGCTACTCTTATTTCTCAAATGGAGTAGAGGAAGTATATGTTCAACATC TTACTCAAATAGGGCTTGGATTAAATCCATATTTTTACATGGGATTGGTCTGGATTTGAATTCAGGCAGAAGTCTCTGTAGATTTGTTCGTTCATTCAAC ATTAACAACAAGGGACAATAAATCTCTCTCTGCCCTCATGGGGCTTACAATTAGGTAGGACGTACTATTTGTAAATAGACATTATATTTTGGGTGTGATG AGGGAAGTAAATGGTACTATGGAGACACTTGTTAGGTAATCTGACCCAATACAAGAGAACTTCTTGGAAAAGGAAACATCCAAATAGAAACCTAAAGCAA GAGATTTACCAGGTAGAGGTAGGGGAAGAAGTGGAGAATATTCCAGGTAGAGAGAATAAAATATTCCAAGATGAGAGAGGAGGGAGAGTACAAGATCTAC CAATAGGGGAACAGAAAGAAGTTTATTTGGCCATAGCATAAAAGGTGAGGATTAAGGGAATCAGATAATAAAATATTTTGTATTCCATGGT

PTPRB.F6 (forward primer)
PTPRB.R6 (reverse primer)
Single exon skipping

Frame 0

EA*TVAKWKMEAEFYMVILTCLIFRNSGFQIVH VQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEK LLHVKSALCLAISNSSRGPSRSAILDRCSQAPR WTCYDQEGFLEVENASLFLQKQGSRVVVKKARK YLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSV RSTRNTAPPQILTTFNAVPDGLVFLIRNTTEAF IRNAAENYSQNSSERQHPNLHMTGITDTSWVLS TTQPFSSTTEETGLAEPERCNFTLAESKASSHSV SIQWRILGSPCNFSLIYSSDTLGAALCPTFRID NTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQ TDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTS YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLT AGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVK DIGISTKANSLLISWSHGSGNVERYRLMLMDKGI LVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEA AGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLK VKWQRPPGNVDSYNITLSHKGTIKESRVLAPWIT ETHFKELVPGRLYQVTVSCVSGELSAQKMAVGR TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQ YRILLFNDSVVLLNITVGKEETQYVMDDTGLVPG RQYEVEVIVESGNLKNSERCQGRTVPLAVLQLR VKHANETSLSIMWQTPVAEWEKYIISLADRDLL LIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGD LKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTN WTQAQGDVEFYQVLLIHENVVIKNESISSETSR YSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRT VPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNY EVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRL YTVTITTRSGKYENHSFSQERTVPDKVQGVSVSN SARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQ TKSIPKSENECVFVQLVPGRLYSVTVTTKSGQY EANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSG ANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYR FTSLTPGRQYKILVLTISGDVQQSAFIEGFTVP SAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVS AFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQI MIASVSGSLKNQINVVGRTVPASVQGVIADNAY SSYSLIVSWQKAAGVAERYDILLLTENGILLRNT SEPATTKQHKFEDLTPGKKYKIQILTVSGGLFS KEAQTEGRTVPAAVTDLRITENSTRHLSFRWTA SEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSF QNLLQGRMYKMVIVTHSGELSNESFIFGRTVPA SVSHLRGSNRNTTDSLWFNWSPASGDFDFYELI LYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW VVTHSGDLSNKVTAESRTAPSPPSLMSFADIAN TSLAITWKGPPDWTDYNDFELQWLPRDALTVFN PYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWK TYSKPIFGSVRTSMTCFATLISQME*RKYMFNI LLK*GLD*IHIFTWDWSGFEFRQKSL*ICSFIQ H*QQGTINLSLPSWGLQLGRTYYL*IDIIFWV** GK*MVLWRHLLGNLTQYKRTSWKRKHPNRNLKQ EIYQVEVGEEVENIPGRENKIFQDERGGRVQDL PIGEQKEVYLAIA*KVRIKGIR**NILYSM

Frame 1

KHEQLLSGKWRLNFTW*FLPA*SSGTQGFRLSM SRNNSVFSKMRKWSWAHATGPSRTSSGCGLRMK SSFMLNLHCAWPSPTLPAAPPAQPSWTAVPRHPD GPAMIRKASLRWKMPLSFSRNKAPE*WSRRPGN TSIAG*K*MSTRRENWSMKASVYKKLAWEQKFR *GALETRLHPRFSLPLMQFQMAWYSLLGIPQRPS SEMLQKTTAKTAARGSIPICT*LELQTHHGFCR LLSPSPAPLKRLDWRSQRDVTSPWRSPRPPAIL CLSSGEFWAHPVTLASSIAVTPWGPRCALPFG*T TPHTDVTFKIYKQEPSITSGLFLWMKREQWSCK QILYLLLGLESVKRRRLQPACMFGGLLLPEKSP HMRCNYLMKITKRYRGFKFKKVLHGMNTLFSISL LVVNTILPSQLFLEENVLFQFIPMDQQCHLQ*K ILVFPQKPILS*FPGPMVLGMWNDTG*C*WIKG S*FMAVLWTNMLLPMLFTG*PLATSTTSLL*LRL QGCKTTGGN*SGQPPWKSQI*R*QMMAV*PL*K SNGKDLLEMWILTISPCLTKGPSRNPEY*HLGL LKLTLKS*SPVDFIKLLSAVSLVNCLLRRWQWAE HFQTKLQTWRQTIMAG*GLL**AGRPLLETGSS IGSYSSMILWCCSTSLWERKKHSMSWMTRGSYR EDSMRWKSLLRVEI*RILSVAKAGQSPWLSSSFV SNMPMKPH*VSCGRPL*QNGRNTSFP*LTETSY *STSHSPKMPKNSLLLTWCLDENTWLQSPVLVE T*KIPLQ*KEEQCLPK*LTCMWPTKE*PVVCLLT GPRHKET*NFTKSY*SMKMWSLKMKASPVRPAD TASTLSSPAACTPWW*QQ*VEGSLPDKWLWREE QSLPV*VE*R*TIPVVMTTSAFPGCWRPEMWITM R*HCLMTARWFSPLSLPSLSENVPSAPSPQAAS TP*P*LQGVASMKITPSAKSGQCLTKSRESVLA TQPGVTI*GYPGCMPLETLITMKSPLKTKTTSFK LKAFPSQKTNVYLFS*SLDGCTVSLLLQKVDNM KPMNKGMGEQFQSLLRI*HCATGALRTCM*LGQ ELMGMSTNMRSSCSSMT*KYFLLFTL*IPQPSID LLP*HQAANTKFLS*RLAGMYSSQPSLRASQFL VLSKIFTFLPMEQQIA*R*TGLLVGETLIPTRC RHSGTVKRLTLRLFPSTSLSTRSTDWRPGSSTRS *LPQSAGP*RIR*MWLGGQFQHLSKE*LQTMHT AVIP***VGKKLLVWQKDMISCF*LKMESFCAT HQSQPPLSNTNLKI*HQARNTRYRS*LSVEASLA RKPRLKAEQSQQLSPT*GSQRTPPGTCPSAGPP QRGSSAGTTSFCTTQMGISRRELKLTH*SRASL SRTCYKAECTRW*L*LTVGSCLMSLSYLVEQSQP L*VISGGPIGTRQTAFGSTGVQPLGTLTFMS*F SIIPMAQRRKTGKTRT*RSGGFKALFLEGSTCC GW*LTVEISAIKSQRRAEQLQVLPVLCHLLTLQT HPWPSRGKGPQTGQTTTTLSCSGCPEMHLLSST PTTTENQKDALCMVFVQGDPINSTSRLSVVIPG KLTANQFLDL*GQV*HVLLLLFLKWSRGSICSTS YSNRAWIKSIFLHGIGLDLNSGRSLCRFVRSFN INNKGQ*ISLCPHGAYN*VGRTICK*TLYFGCD EGSKWYYGDTC*VI*PNTRELLGKGNIQIET*SK RFTR*R*GKKWRIFQVERIKYSKMREEGEYKIY Q*GNRKKFIWP*HKR*GLRESDNKIFCIPW

Frame 2

SMNSC*VENGG*ILHGDSYLLDLQELRVSDCPC PETTVSFQK*ESGRGLMQQDHPEPAVDVD*G*K APSC*ICTVLGHLQLFPRPLPLSHLGPLFPGTP MDLL*SGRLP*GGKCLSLSPETRLQSSGQEGQEI PP*LDENRCQQGGKTGQ*KPLFTKSWPGSRSFG EEH*KHGSTPDSHYL*CSSRWPGIPY*EYHRGL HQKCCRKLQPKQQREAASQSAHDWNYRHIMGFVD YSALLQHH*RDWTGGAREM*LHPGGVQGLQPFC VYPVENFGLTL*L*PHL*Q*HPGGRVVPYLSDR QHHIRM*PSRFTSRNHL*LQDYFSG*RENSGLAN RSFTSC*VWSQ*REDDFNQLACLVDSFFRKSHL I*GAII**K*PKDTGGSNSRKYFME*IHFFQSH CW**IQYCHHSCFWRKTFFFSLYQWINSAISSER YWYFHKSQFSPDFLVPWFWECGTIPADANG*RD PSSWRCCGQTCYFLCFSRADPWLPLQPHCYD*G CRAAKLQVETSQDSPHGSLKSEGDK*WQFDLSKS QMAKTSWKCGFLQYHPVSQRDHQGIQSISTLDY *NSL*RVSPRSTLSSYCQLCLW*TVCSEDGSGQ NISRQSCKPGGKQ*WQDEVSCSELVAPCWRLGAV SDPTLQ*FCGAAQHHCGKGRNTVCHG*HGARTG KTV*GGSHC*EWKFEEF*ALPRQDSPPGCPPAS CQTCQ*NLTEYHVADPCSRMGEIHHFPS*QRPLT DPQVTLQRCQRIHFY*PGAWTKIHGYSHQY*WR LKKFLFSKRKNSACPSD*LACGQPRNDQ*SVY* LDPGTRRRRILPSLTDP*KCGH*K*KHLQ*DQQI QLPLSQVRQPVLRGGNNSEWRDLFPTSGCGGKN SPFQCEWSNGEQFRS**LPQRFLAAGARRCG*L *GNIVS*RQGGSVPCHCQVCQRMFLQLPHPRPPL HRDHNYKEWQV*KSLLQPRADSA*QSPGSQC*Q LSQE*LFKGILGACHWRL*SL*SHH*KQKQLHS N*KHSQVRKRMCICSASPWTVVQCHCYYKKWTI* SQ*TREWENNSRAC*GSNIAQQEH*GLACDLVR S*WGCRPI*DPAALQ*HESISSFSPCKYRNRVS IYFPNTRPPIQNSCLDD*RGCTAVSLH*GLHSS* CCQKYSHFSQWSNR*PDGELDSWWGRR*FLHGV GIQAQSKG*LSDYSQARL*AHVPQTGGRGAVPD HDCLSQRVPEESDKCGWADSSSICPRSNCRQCIQ QLFLNSKLAKSCWCGRKI*YPASN*KWNPSAQH IRASHH*ATQI*RSNTRQEIQDTDPNCQWRPL* QGSPD*RPNSPSSCHRPEDHRELHQAPVLPLDRL RGGAQLVQHLFVQPRWESPGESSS*PTSPELLF PELATRQNVQDGDCNSQWGAV**VFHIW*NSPS LCESSQGVQSEHDRQPLVQLESSLWGL*LL*ADS L*SQWHKEGKLERQGPDGVAVSRPCSWKEVRAV GGNSQWRSQQ*SHSGEQNSSKSSQSYVIC*HCK HILGHHVERAPRLDRLQRL*AAVVAQRCTYCLQP LQQQKIRRTHCVWSSSREILSIQRQDCQW*FLE NLQQTNFWICEDKYDMFCYSYFSNGVEEVYVQH LTQIGLGLNPYFYMGLVWI*IQAEVSVDLFVHST LTTRDNKSLSALMGLTIR*DVLFVNRHYILGVM REVNGTMETLVR*SDPIQENFLEKETSK*KPKA RDLPGRGRGRSGEYSR*RE*NIPR*ERRESTRST NRGTERSLFGHSIKGED*GNQIIKYFVFHG

Sequence PTPRB.eAug05

PTPRB.F6 (forward primer)
PTPRB.R6 (reverse primer)
Single exon skipping

Frame 0

EA*TVAKWKMEAEFYMVILTCLIFRNSEGFQIV HVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDE KLLHVKSALCLAFIRNAAENYSQNSSERQHPNL HMTGITDTSWVLSTTQPFSSTTEETGLAEPERC NFTLAESKASSHSVSIQWRILGSPCNFSLIYSSD TLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFR IISLDEERTVVLQTDPLPPARFGVSKEKTTSTS LHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQE STSWNEYTFFNLTAGSKYNIAITAVSGGKRSFS VYTNGSTVPSPVKDIGISTKANSLLISWSHGSG NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLT PGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSN LKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHK GTIKESRVLAPWITETHFKELVPGRLYQVTVSCV SGELSAQKMAVGRTFPDKVANLEANNNGRMRSL VVSWSPPAGDWEQYRILLFNDSVVLLNITVGKE ETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERC QGRTVPLAVLQLRVKHANETSLSIMWQTPVAEW EKYIISLADRDLLLIHKSLSKDAKEFTFTDLVP GRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLH VANQGMTSSLFTNWTQAQGDVEFYQVLLIHENV VIKNESISSETSRYSFHSLKSGSLYSVVVTTVS GGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLS VSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSV RECSFSSLTPGRLYTVTITTRSGKYENHSFSQE RTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDH YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGR LYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTL RNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVF PPFHLVNTATEYRFTSLTPGRQYKILVLTISGD VQQSAFIEGFTVPSAVKNIHISPNGATDSLTVN WTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEH TFHRLEAGEQYQIMIASVSGSLKNQINVVGRTV PASVQGVIADNAYSSYSLIVSWQKAAGVAERYD ILLLTENGILLRNTSEPATTKQHKFEDLTPGKKY KIQILTVSGGLFSKEAQTEGRTVPAAVTDLRIT ENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQ ERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGEL SNESFIFGRTVPASVSHLRGSNRNTTDSLWFNW SPASGDFDFYELILYNPNGTKKENWKDKDLTEW RFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP SPPSLMSFADIANTSLAITWKGPPDWTDYNDFE LQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRS YQFNVKTVSGDSWKTYSKPIFGSVRTSMTCFATL ISQME*RKYMFNILLK*GLD*IHIFTWDWSGFE FRQKSL*ICSFIQH*QQGTINLSLPSWGLQLGR TYYL*IDIIFWV**GK*MVLWRHLLGNLTQYKRT SWKRKHPNRNLKQEIYQVEVGEEVENIPGRENK IFQDERGGRVQDLPIGEQKEVYLAIA*KVRIKG IR**NILYSM

Frame 1

KHEQLLSGKWRLNFTW*FLPA*SSGTQKGFRLS MSRNNSVFSKMRKWSWAHATGPSRTSSGCGLRM KSSFMLNLHCAWPSSEMLQKTTAKTAARGSIPIC T*LELQTHHGFCRLLSPSPAPLKRLDWRSQRDV TSPWRSPRPPAILCLSSGEFWAHPVTLASSIAV TPWGPRCALPFG*TTPHTDVTFKIYKQEPSITSG LFLWMKREQWSCKQILYLLLGLESVKRRRLQPA CMFGGLLLPEKSPHMRCNYLMKITKRYRGFKFK KVLHGMNTLFSISLLVVNTILPSQLFLEENVLFQ FIPMDQQCHLQ*KILVFPQKPILS*FPGPMVLG MWNDTG*C*WIKGS*FMAVLWTNMLLPMLFTG* PLATSTTSLL*LRLQGCKTTGGN*SGQPPWKSQI *R*QMMAV*PL*KSNGKDLLEMWILTISPCLTK GPSRNPEY*HLGLLKLTLKS*SPVDFIKLLSAV SLVNCLLRRWQWAEHFQTKLQTWRQTIMAG*GLL **AGRPLLETGSSIGSYSSMILWCCSTSLWERK KHSMSWMTRGSYREDSMRWKSLLRVEI*RILSV AKAGQSPWLSSSFVSNMPMKPH*VSCGRPL*QNG RNTSFP*LTETSY*STSHSPKMPKNSLLLTWCL DENTWLQSPVLVET*KIPLQ*KEEQCLPK*LTC MWPTKE*PVVCLLTGPRHKET*NFTKSY*SMKMW SLKMKASPVRPADTASTLSSPAACTPWW*QQ*V EGSLPDKWLWREEQSLPV*VE*R*TIPVVMTTS AFPGCWRPEMWITMR*HCLMTARWFSPLSLPSLS ENVPSAPSPQAASTP*P*LQGVASMKITPSAKS GQCLTKSRESVLATQPGVTI*GYPGCMPLETLI TMKSPLKTKTTSFKLKAFPSQKTNVYLFS*SLDG CTVSLLLQKVDNMKPMNKGMGEQFQSLLRI*HC ATGALRTCM*LGQELMGMSTNMRSSCSSMT*KY FLLFTL*IPQPSIDLLP*HQAANTKFLS*RLAGM YSSQPSLRASQFLVLSKIFTFLPMEQQIA*R*T GLLVGETLIPTRCRHSGTVKRLTLRLFPSTSLS TRSTDWRPGSSTRS*LPQSAGP*RIR*MWLGGQF QHLSKE*LQTMHTAVIP***VGKKLLVWQKDMI SCF*LKMESFCATHQSQPPLSNTNLKI*HQARN TRYRS*LSVEASLARKPRLKAEQSQQLSPT*GSQ RTPPGTCPSAGPPQRGSSAGTTSFCTTQMGISR RELKLTH*SRASLSRTCYKAECTRW*L*LTVGS CLMSLSYLVEQSQPL*VISGGPIGTRQTAFGSTG VQPLGTLTFMS*FSIIPMAQRRKTGKTRT*RSG GFKALFLEGSTCCGW*LTVEISAIKSQRRAEQL QVLPVLCHLLTLQTHPWPSRGKGPQTGQTTTTLS CSGCPEMHLLSSTPTTTENQKDALCMVFVQGDP INSTSRLSVVIPGKLTANQFLDL*GQV*HVLLL LFLKWSRGSICSTSYSNRAWIKSIFLHGIGLDLN SGRSLCRFVRSFNINNKGQ*ISLCPHGAYN*VG RTICK*TLYFGCDEGSKWYYGDTC*VI*PNTRE LLGKGNIQIET*SKRFTR*R*GKKWRIFQVERIK YSKMREEGEYKIYQ*GNRKKFIWP*HKR*GLRE SDNKIFCIPW

Frame 2

SMNSC*VENGG*ILHGDSYLLDLQELRRVSDCP CPETTVSFQK*ESGRGLMQQDHPEPAVDVD*G* KAPSC*ICTVLGLHQKCCRKLQPKQQREAASQS AHDWNYRHIMGFVDYSALLQHH*RDWTGGAREM* LHPGGVQGLQPFCVYPVENFGLTL*L*PHL*Q* HPGGRVVPYLSDRQHHIRM*PSRFTSRNHL*LQ DYFSG*RENSGLANRSFTSC*VWSQ*REDDFNQL ACLVDSFFRKSHLI*GAII**K*PKDTGGSNSR KYFME*IHFFQSHCW**IQYCHHSCFWRKTFFF SLYQWINSAISSERYWYFHKSQFSPDFLVPWFWE CGTIPADANG*RDPSSWRCCGQTCYFLCFSRAD PWLPLQPHCYD*GCRAAKLQVETSQDSPHGSLK SEGDK*WQFDLSKSQMAKTSWKCGFLQYHPVSQR DHQGIQSISTLDY*NSL*RVSPRSTLSSYCQLC LW*TVCSEDGSGQNISRQSCKPGGKQ*WQDEVS CSELVAPCWRLGAVSDPTLQ*FCGAAQHHCGKGR NTVCHG*HGARTGKTV*GGSHC*EWKFEEF*AL PRQDSPPGCPPASCQTCQ*NLTEYHVADPCSRM GEIHHFPS*QRPLTDPQVTLQRCQRIHFY*PGAW TKIHGYSHQY*WRLKKFLFSKRKNSACPSD*LA CGQPRNDQ*SVY*LDPGTRRRRILPSLTDP*KC GH*K*KHLQ*DQQIQLPLSQVRQPVLRGGNNSEW RDLFPTSGCGGKNSPFQCEWSNGEQFRS**LPQ RFLAAGARRCG*L*GNIVS*RQGGSVPCHCQVC QRMFLQLPHPRPPLHRDHNYKEWQV*KSLLQPRA DSA*QSPGSQC*QLSQE*LFKGILGACHWRL*S L*SHH*KQKQLHSN*KHSQVRKRMCICSASPWT VVQCHCYYKKWTI*SQ*TREWENNSRAC*GSNIA QQEH*GLACDLVRS*WGCRPI*DPAALQ*HESI SSFSPCKYRNRVSIYFPNTRPPIQNSCLDD*RG CTAVSLH*GLHSS*CCQKYSHFSQWSNR*PDGEL DSWWGRR*FLHGVGIQAQSKG*LSDYSQARL*A HVPQTGGRGAVPDHDCLSQRVPEESDKCGWADS SSICPRSNCRQCIQQLFLNSKLAKSCWCGRKI*Y PASN*KWNPSAQHIRASHH*ATQI*RSNTRQEI QDTDPNCQWRPL*QGSPD*RPNSPSSCHRPEDH RELHQAPVLPLDRLRGGAQLVQHLFVQPRWESPG ESSS*PTSPELLFPELATRQNVQDGDCNSQWGA V**VFHIW*NSPSLCESSQGVQSEHDRQPLVQL ESSLWGL*LL*ADSL*SQWHKEGKLERQGPDGVA VSRPCSWKEVRAVGGNSQWRSQQ*SHSGEQNSS KSSQSYVIC*HCKHILGHHVERAPRLDRLQRL* AAVVAQRCTYCLQPLQQQKIRRTHCVWSSSREIL SIQRQDCQW*FLENLQQTNFWICEDKYDMFCYS YFSNGVEEVYVQHLTQIGLGLNPYFYMGLVWI* IQAEVSVDLFVHSTLTTRDNKSLSALMGLTIR*D VLFVNRHYILGVMREVNGTMETLVR*SDPIQEN FLEKETSK*KPKARDLPGRGRGRSGEYSR*RE* NIPR*ERRESTRSTNRGTERSLFGHSIKGED*GN QIIKYFVFHG