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Sequences

Sequence NOTCH3.cAug05

CGAACCCCTGTGAGCATGGGGGCCGCTGCGAGTCTGCCCCTGGCCAGCTGCCTGTCTGCTCCTGCCCCCAGGGCTGGCAAGACCCATGCCTGAACGGTGG CTCGTGCCAAGACGGCGTGGGCTCCTTTTCCTGCTCCTGCCTCCCTGGTTTCGCCGGCCCACGATGCGCCCGCGATGTGGATGAGTGCCTGAGCAACCCC TGCGGCCCGGGCACCTGTACCGACCACGTGGCCTCCTTCACCTGCACCTGCCCGCCAGGCTACGGAGGCTTCCACTGCGAACAGGACCTGCCCGACTGCA GCCCCAGCTCCTGCTTCAATGGCGGGACCTGTGTGGACGGCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACAGGAGCCCACTGCCAACATGA GGCAGACCCCTGCCTCTCGCGGCCCTGCCTACACGGGGGCGTCTGCAGCGCCGCCCACCCTGGCTTCCGCTGCACCTGC

NOTCH3.F2 (forward primer)
NOTCH3.R2 (reverse primer)
Single exon skipping

Frame 0

RTPVSMGAAASLPLASCLSAPAPRAGKTHA*TV ARAKTAWAPFPAPASLVSPAHDAPAMWMSA*ATP AARAPVPTTWPPSPAPARQATEASTANRTCPTA APAPASMAGPVWTA*TRSAACAVPATQEPTANM RQTPASRGPAYTGASAAPPTLASAAP

Frame 1

EPL*AWGPLRVCPWPAACLLLPPGLARPMPERW LVPRRRGLLFLLLPPWFRRPTMRPRCG*VPEQP LRPGHLYRPRGLLHLHLPARLRRLPLRTGPARLQ PQLLLQWRDLCGRRELVQLPVPSRLHRSPLPT* GRPLPLAALPTRGRLQRRPPWLPLHL

Frame 2

NPCEHGGRCESAPGQLPVCSCPQGWQDPCLNGG SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP CGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDC SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE ADPCLSRPCLHGGVCSAAHPGFRCTC

Sequence NOTCH3.aAug05

GCGGCGCGGAGGCTGGCCCGGGACGCGCCCGGAGCCCAGGGAAGGAGGGAGGAGGGGAGGGTCGCGGCCGGCCGCCATGGGGCCGGGGGCCCGTGGCCGC CGCCGCCGCCGTCGCCCGATGTCGCCGCCACCGCCACCGCCACCCGTGCGGGCGCTGCCCCTGCTGCTGCTGCTAGCGGGGCCGGGGGCTGCAGCCCCCC CTTGCCTGGACGGAAGCCCGTGTGCAAATGGAGGTCGTTGCACCCAGCTGCCCTCCCGGGAGGCTGCCTGCCTGTGCCCGCCTGGCTGGGTGGGTGAGCG GTGTCAGCTGGAGGACCCCTGTCACTCAGGCCCCTGTGCTGGCCGTGGTGTCTGCCAGAGTTCAGTGGTGGCTGGCACCGCCCGATTCTCATGCCGGTGC CCCCGTGGCTTCCGAGGCCCTGACTGCTCCCTGCCAGATCCCTGCCTCAGCAGCCCTTGTGCCCACGGTGCCCGCTGCTCAGTGGGGCCCGATGGACGCT TCCTCTGCTCCTGCCCACCTGGCTACCAGGGCCGCAGCTGCCGAAGCGACGTGGATGAGTGCCGGGTGGGTGAGCCCTGCCGCCATGGTGGCACCTGCCT CAACACACCTGGCTCCTTCCGCTGCCAGTGTCCAGCTGGCTACACAGGGCCACTATGTGAGAACCCCGCGGTGCCCTGTGCACCCTCACCATGCCGTAAC GGGGGCACCTGCAGGCAGAGTGGCGACCTCACTTACGACTGTGCCTGTCTTCCTGGGTTTGAGGGTCAGAATTGTGAAGTGAACGTGGACGACTGTCCAG GACACCGATGTCTCAATGGGGGGACATGCGTGGATGGCGTCAACACCTATAACTGCCAGTGCCCTCCTGAGTGGACAGGCCAGTTCTGCACGGAGGACGT GGATGAGTGTCAGCTGCAGCCCAACGCCTGCCACAATGGGGGTACCTGCTTCAACACGCTGGGTGGCCACAGCTGCGTGTGTGTCAATGGCTGGACAGGC GAGAGCTGCAGTCAGAATATCGATGACTGTGCCACAGCCGTGTGCTTCCATGGGGCCACCTGCCATGACCGCGTGGCTTCTTTCTACTGTGCCTGCCCCA TGGGCAAGACTGGCCTCCTGTGTCACCTGGATGACGCCTGTGTCAGCAACCCCTGCCACGAGGATGCTATCTGTGACACAAATCCGGTGAACGGCCGGGC CATTTGCACCTGTCCTCCCGGCTTCACGGGTGGGGCATGTGACCAGGATGTGGACGAGTGCTCTATCGGCGCCAACCCCTGCGAGCACTTGGGCAGGTGC GTGAACACGCAGGGCTCCTTCCTGTGCCAGTGCGGTCGTGGCTACACTGGACCTCGCTGTGAGACCGATGTCAACGAGTGTCTGTCGGGGCCCTGCCGAA ACCAGGCCACGTGCCTCGACCGCATAGGCCAGTTCACCTGTATCTGTATGGCAGGCTTCACAGGAACCTATTGCGAGGTGGACATTGACGAGTGTCAGAG TAGCCCCTGTGTCAACGGTGGGGTCTGCAAGGACCGAGTCAATGGCTTCAGCTGCACCTGCCCCTCGGGCTTCAGCGGCTCCACGTGTCAGCTGGACGTG GACGAATGCGCCAGCACGCCCTGCAGGAATGGCGCCAAATGCGTGGACCAGCCCGATGGCTACGAGTGCCGCTGTGCCGAGGGCTTTGAGGGCACGCTGT GTGATCGCAACGTGGACGACTGCTCCCCTGACCCATGCCACCATGGTCGCTGCGTGGATGGCATCGCCAGCTTCTCATGTGCCTGTGCTCCTGGCTACAC GGGCACACGCTGCGAGAGCCAGGTGGACGAATGCCGCAGCCAGCCCTGCCGCCATGGCGGCAAATGCCTAGACCTGGTGGACAAGTACCTCTGCCGCTGC CCTTCTGGGACCACAGGTGTGAACTGCGAAGTGAACATTGACGACTGTGCCAGCAACCCCTGCACCTTTGGAGTCTGCCGTGATGGCATCAACCGCTACG ACTGTGTCTGCCAACCTGGCTTCACAGGGCCCCTTTGTAACGTGGAGATCAATGAGTGTGCTTCCAGCCCATGCGGCGAGGGAGGTTCCTGTGTGGATGG GGAAAATGGCTTCCGCTGCCTCTGCCCGCCTGGCTCCTTGCCCCCACTCTGCCTCCCCCCGAGCCATCCCTGTGCCCATGAGCCCTGCAGTCACGGCATC TGCTATGATGCACCTGGCGGGTTCCGCTGTGTGTGTGAGCCTGGCTGGAGTGGCCCCCGCTGCAGCCAGAGCCTGGCCCGAGACGCCTGTGAGTCCCAGC CGTGCAGGGCCGGTGGGACATGCAGCAGCGATGGAATGGGTTTCCACTGCACCTGCCCGCCTGGTGTCCAGGGACGTCAGTGTGAACTCCTCTCCCCCTG CACCCCGAACCCCTGTGAGCATGGGGGCCGCTGCGAGTCTGCCCCTGGCCAGCTGCCTGTCTGCTCCTGCCCCCAGGGCTGGCAAGGCCCACGATGCCAG CAGGATGTGGACGAGTGTGCTGGCCCCGCACCCTGTGGCCCTCATGGTATCTGCACCAACCTGGCAGGGAGTTTCAGCTGCACCTGCCATGGAGGGTACA CTGGCCCTTCCTGCGATCAGGACATCAATGACTGTGACCCCAACCCATGCCTGAACGGTGGCTCGTGCCAAGACGGCGTGGGCTCCTTTTCCTGCTCCTG CCTCCCTGGTTTCGCCGGCCCACGATGCGCCCGCGATGTGGATGAGTGCCTGAGCAACCCCTGCGGCCCGGGCACCTGTACCGACCACGTGGCCTCCTTC ACCTGCACCTGCCCGCCAGGCTACGGAGGCTTCCACTGCGAACAGGACCTGCCCGACTGCAGCCCCAGCTCCTGCTTCAATGGCGGGACCTGTGTGGACG GCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACAGGAGCCCACTGCCAACATGAGGCAGACCCCTGCCTCTCGCGGCCCTGCCTACACGGGGG CGTCTGCAGCGCCGCCCACCCTGGCTTCCGCTGCACCTGCCTCGAGAGCTTCACGGGCCCGCAGTGCCAGACGCTGGTGGATTGGTGCAGCCGCCAGCCT TGTCAAAACGGGGGTCGCTGCGTCCAGACTGGGGCCTATTGCCTTTGTCCCCCTGGATGGAGCGGACGCCTCTGTGACATCCGAAGCTTGCCCTGCAGGG AGGCCGCAGCCCAGATCGGGGTGCGGCTGGAGCAGCTGTGTCAGGCGGGTGGGCAGTGTGTGGATGAAGACAGCTCCCACTACTGCGTGTGCCCAGAGGG CCGTACTGGTAGCCACTGTGAGCAGGAGGTGGACCCCTGCTTGGCCCAGCCCTGCCAGCATGGGGGGACCTGCCGTGGCTATATGGGGGGCTACATGTGT GAGTGTCTTCCTGGCTACAATGGTGATAACTGTGAGGACGACGTGGACGAGTGTGCCTCCCAGCCCTGCCAGCACGGGGGTTCATGCATTGACCTCGTGG CCCGCTATCTCTGCTCCTGTCCCCCAGGAACGCTGGGGGTGCTCTGCGAGATTAATGAGGATGACTGCGGCCCAGGCCCACCGCTGGACTCAGGGCCCCG GTGCCTACACAATGGCACCTGCGTGGACCTGGTGGGTGGTTTCCGCTGCACCTGTCCCCCAGGATACACTGGTTTGCGCTGCGAGGCAGACATCAATGAG TGTCGCTCAGGTGCCTGCCACGCGGCACACACCCGGGACTGCCTGCAGGACCCAGGCGGAGGTTTCCGTTGCCTTTGTCATGCTGGCTTCTCAGGTCCTC GCTGTCAGACTGTCCTGTCTCCCTGCGAGTCCCAGCCATGCCAGCATGGAGGCCAGTGCCGTCCTAGCCCGGGTCCTGGGGGTGGGCTGACCTTCACCTG TCACTGTGCCCAGCCGTTCTGGGGTCCGCGTTGCGAGCGGGTGGCGCGCTCCTGCCGGGAGCTGCAGTGCCCGGTGGGCGTCCCATGCCAGCAGACGCCC CGCGGGCCGCGCTGCGCCTGCCCCCCAGGGTTGTCGGGACCCTCCTGCCGCAGCTTCCCGGGGTCGCCGCCGGGGGCCAGCAACGCCAGCTGCGCGGCCG CCCCCTGTCTCCACGGGGGCTCCTGCCGCCCCGCGCCGCTCGCGCCCTTCTTCCGCTGCGCTTGCGCGCAGGGCTGGACCGGGCCGCGCTGCGAGGCGCC CGCCGCGGCACCCGAGGTCTCGGAGGAGCCGCGGTGCCCGCGCGCCGCCTGCCAGGCCAAGCGCGGGGACCAGCGCTGCGACCGCGAGTGCAACAGCCCA GGCTGCGGCTGGGACGGCGGCGACTGCTCGCTGAGCGTGGGCGACCCCTGGCGGCAATGCGAGGCGCTGCAGTGCTGGCGCCTCTTCAACAACAGCCGCT GCGACCCCGCCTGCAGCTCGCCCGCCTGCCTCTACGACAACTTCGACTGCCACGCCGGTGGCCGCGAGCGCACTTGCAACCCGGTGTACGAGAAGTACTG CGCCGACCACTTTGCCGACGGCCGCTGCGACCAGGGCTGCAACACGGAGGAGTGCGGCTGGGATGGGCTGGATTGTGCCAGCGAGGTGCCGGCCCTGCTG GCCCGCGGCGTGCTGGTGCTCACAGTGCTGCTGCCGCCAGAGGAGCTACTGCGTTCCAGCGCCGACTTTCTGCAGCGGCTCAGCGCCATCCTGCGCACCT CGCTGCGCTTCCGCCTGGACGCGCACGGCCAGGCCATGGTCTTCCCTTACCACCGGCCTAGTCCTGGCTCCGAACCCCGGGCCCGTCGGGAGCTGGCCCC CGAGGTGATCGGCTCGGTAGTAATGCTGGAGATTGACAACCGGCTCTGCCTGCAGTCGCCTGAGAATGATCACTGCTTCCCCGATGCCCAGAGCGCCGCT GACTACCTGGGAGCGTTGTCAGCGGTGGAGCGCCTGGACTTCCCGTACCCACTGCGGGACGTGCGGGGGGAGCCGCTGGAGCCTCCAGAACCCAGCGTCC CGCTGCTGCCACTGCTAGTGGCGGGCGCTGTCTTGCTGCTGGTCATTCTCGTCCTGGGTGTCATGGTGGCCCGGCGCAAGCGCGAGCACAGCACCCTCTG GTTCCCTGAGGGCTTCTCACTGCACAAGGACGTGGCCTCTGGTCACAAGGGCCGGCGGGAACCCGTGGGCCAGGACGCGCTGGGCATGAAGAACATGGCC AAGGGTGAGAGCCTGATGGGGGAGGTGGCCACAGACTGGATGGACACAGAGTGCCCAGAGGCCAAGCGGCTAAAGGTAGAGGAGCCAGGCATGGGGGCTG AGGAGGCTGTGGATTGCCGTCAGTGGACTCAACACCATCTGGTTGCTGCTGACATCCGCGTGGCACCAGCCATGGCACTGACACCACCACAGGGCGACGC AGATGCTGATGGCATGGATGTCAATGTGCGTGGCCCAGATGGCTTCACCCCGCTAATGCTGGCTTCCTTCTGTGGGGGGGCTCTGGAGCCAATGCCAACT GAAGAGGATGAGGCAGATGACACATCAGCTAGCATCATCTCCGACCTGATCTGCCAGGGGGCTCAGCTTGGGGCACGGACTGACCGTACTGGCGAGACTG CTTTGCACCTGGCTGCCCGTTATGCCCGTGCTGATGCAGCCAAGCGGCTGCTGGATGCTGGGGCAGACACCAATGCCCAGGACCACTCAGGCCGCACTCC CCTGCACACAGCTGTCACAGCCGATGCCCAGGGTGTCTTCCAGATTCTCATCCGAAACCGCTCTACAGACTTGGATGCCCGCATGGCAGATGGCTCAACG GCACTGATCCTGGCGGCCCGCCTGGCAGTAGAGGGCATGGTGGAAGAGCTCATCGCCAGCCATGCTGATGTCAATGCTGTGGATGAGCTTGGGAAATCAG CCTTACACTGGGCTGCGGCTGTGAACAACGTGGAAGCCACTTTGGCCCTGCTCAAAAATGGAGCCAATAAGGACATGCAGGATAGCAAGGAGGAGACCCC CCTATTCCTGGCCGCCCGCGAGGGCAGCTATGAGGCTGCCAAGCTGCTGTTGGACCACTTTGCCAACCGTGAGATCACCGACCACCTGGACAGGCTGCCG CGGGACGTAGCCCAGGAGAGACTGCACCAGGACATCGTGCGCTTGCTGGATCAACCCAGTGGGCCCCGCAGCCCCCCCGGTCCCCACGGCCTGGGGCCTC TGCTCTGTCCTCCAGGGGCCTTCCTCCCTGGCCTCAAAGCGGCACAGTCGGGGTCCAAGAAGAGCAGGAGGCCCCCCGGGAAGGCGGGGCTGGGGCCGCA GGGGCCCCGGGGGCGGGGCAAGAAGCTGACGCTGGCCTGCCCGGGCCCCCTGGCTGACAGCTCGGTCACGCTGTCGCCCGTGGACTCGCTGGACTCCCCG CGGCCTTTCGGTGGGCCCCCTGCTTCCCCTGGTGGCTTCCCCCTTGAGGGGCCCTATGCAGCTGCCACTGCCACTGCAGTGTCTCTGGCACAGCTTGGTG GCCCAGGCCGGGCGGGTCTAGGGCGCCAGCCCCCTGGAGGATGTGTACTCAGCCTGGGCCTGCTGAACCCTGTGGCTGTGCCCCTCGATTGGGCCCGGCT GCCCCCACCTGCCCCTCCAGGCCCCTCGTTCCTGCTGCCACTGGCGCCGGGACCCCAGCTGCTCAACCCAGGGACCCCCGTCTCCCCGCAGGAGCGGCCC CCGCCTTACCTGGCAGTCCCAGGACATGGCGAGGAGTACCCGGCGGCTGGGGCACACAGCAGCCCCCCAAAGGCCCGCTTCCTGCGGGTTCCCAGTGAGC ACCCTTACCTGACCCCATCCCCCGAATCCCCTGAGCACTGGGCCAGCCCCTCACCTCCCTCCCTCTCAGACTGGTCCGAATCCACGCCTAGCCCAGCCAC TGCCACTGGGGCCATGGCCACCACCACTGGGGCACTGCCTGCCCAGCCACTTCCCTTGTCTGTTCCCAGCTCCCTTGCTCAGGCCCAGACCCAGCTGGGG CCCCAGCCGGAAGTTACCCCCAAGAGGCAAGTGTTGGCCTGAGACGCTCGTCAGTTCTTAGATCTTGGGGGCCTAAAGAGACCCCCGTCCTGCCTCCTTT CTTTCTCTGTCTCTTCCTTCCTTTTAGTCTTTTTCATCCTCTTCTCTTTCCACCAACCCTCCTGCATCCTTGCCTTGCAGCGTGACCGAGATAGGTCATC AGCCCAGGGCTTCAGTCTTCCTTTATTTATAATGGGTGGGGGCTACCACCCACCCTCTCAGTCTTGTGAAGAGTCTGGGACCTCCTTCTTCCCCACTTCT CTCTTCCCTCATTCCTTTCTCTCTCCTTCTGGCCTCTCATTTCCTTACACTCTGACATGAATGAATTATTATTATTTTTATTTTTCTTTTTTTTTTTACA TTTTGTATAGAAACAAATTCATTTAAACAAACTTATTATTATTATTTTTTACAAAATATATATATGGAGATGCTCCCTCCCCCTGTGAACCCCCCAGTGC CCCCGTGGGGCTGAGTCTGTGGGCCCATTCGGCCAAGCTGGATTCTGTGTACCTAGTACACAGGCATGACTGGGATCCCGTGTACCGAGTACACGACCCA GGTATGTACCAAGTAGGCACCCTTGGGCGCACCCACTGGGGCCAGGGGTCGGGGGAGTGTTGGGAGCCTCCTCCCCACCCCACCTCCCTCACTTCACTGC ATTCCAGATGGGACATGTTCCATAGCCTTGCTGGGGAAGGGCCCACTGCCAACTCCCTCTGCCCCAGCCCCACCCTTGGCCATCTCCCTTTGGGAACTAG GGGGCTGCTGGTGGGAAATGGGAGCCAGGGCAGATGTATGCATTCCTTTGTGTCCCTGTAAATGTGGGACTACAAGAAGAGGAGCTGCCTGAGTGGTACT TTCTCTTCCTGGTAATCCTCTGGCCCAGCCTCATGGCAGAATAGAGGTATTTTTAGGCTATTTTTGTAATATGGCTTCTGGTCAAAATCCCTGTGTAGCT GAATTCCCAAGCCCTGCATTGTACAGCCCCCCACTCCCCTCACCACCTAATAAAGGAATAGTTAACACTCAGTGTTGTTGGTCTGTGTCTAGGTAAGGTG GGGAGTGGTGGCAGTGGGACTTCTATCTCCCCCACCCAGGGCTAACTTGAGCTCCCATCTTGGGGTAAATACATTTGACTTGCCAGTCTACTTATGCTTC CTCTTTTGGCAGATGACTACCGATTGGATTAGTGGTTGTCACCTGACTTAAGCTGAGCCAATCAGATTCTTTTGCTCGAGAACTTTCTTTAATGGAGAGG CTAAGAAAGTTGTCAGTTGGTGGAGCTCTTAAGGTCACAATCAGATTTAGAAATATCAGTGGCCAATTCGAGGTGGTGGGCAAAGAGACAAGCAAACAGG GCAGAAGAATGAAGCTAATATTCAGGGAGAATCAGAAATGAGAGCTCAAATGGCTCCTTGAGGGCTGGGGGGGTTATCTCGGCTCCCAGTGCAGTTATCA ATTCCAGTTAATTGAGTGTTCATTCCATTGAGATCAACAGGTATTTATTAATTGCTTTCTAAGTATCTGATCATGGTTCTGCATGAATTTCACTTTTACT TCATGCTCCTATGGGTTTTGGAGATAACCTTGGACCCATGTAATAAATACTTCTTTACTTGTGCCA

NOTCH3.F2 (forward primer)
NOTCH3.R2 (reverse primer)
Single exon skipping

Frame 0

AARRLARDAPGAQGRREEGRVAAGRHGAGGPWP PPPPSPDVAATATATRAGAAPAAAASGAGGCSPP LPGRKPVCKWRSLHPAALPGGCLPVPAWLGG*A VSAGGPLSLRPLCWPWCLPEFSGGWHRPILMPV PPWLPRP*LLPARSLPQQPLCPRCPLLSGARWTL PLLLPTWLPGPQLPKRRG*VPGG*ALPPWWHLP QHTWLLPLPVSSWLHRATM*EPRGALCTLTMP* RGHLQAEWRPHLRLCLSSWV*GSEL*SERGRLSR TPMSQWGDMRGWRQHL*LPVPS*VDRPVLHGGR G*VSAAAQRLPQWGYLLQHAGWPQLRVCQWLDR RELQSEYR*LCHSRVLPWGHLP*PRGFFLLCLPH GQDWPPVSPG*RLCQQPLPRGCYL*HKSGERPG HLHLSSRLHGWGM*PGCGRVLYRRQPLRALGQV REHAGLLPVPVRSWLHWTSL*DRCQRVSVGALPK PGHVPRPHRPVHLYLYGRLHRNLLRGGH*RVSE *PLCQRWGLQGPSQWLQLHLPLGLQRLHVSAGR GRMRQHALQEWRQMRGPARWLRVPLCRGL*GHAV *SQRGRLLP*PMPPWSLRGWHRQLLMCLCSWLH GHTLREPGGRMPQPALPPWRQMPRPGGQVPLPL PFWDHRCELRSEH*RLCQQPLHLWSLP*WHQPLR LCLPTWLHRAPL*RGDQ*VCFQPMRRGRFLCGW GKWLPLPLPAWLLAPTLPPPEPSLCP*ALQSRH LL*CTWRVPLCV*AWLEWPPLQPEPGPRRL*VPA VQGRWDMQQRWNGFPLHLPAWCPGTSV*TPLPL HPEPL*AWGPLRVCPWPAACLLLPPGLARPTMP AGCGRVCWPRTLWPSWYLHQPGREFQLHLPWRVH WPFLRSGHQ*L*PQPMPERWLVPRRRGLLFLLL PPWFRRPTMRPRCG*VPEQPLRPGHLYRPRGLL HLHLPARLRRLPLRTGPARLQPQLLLQWRDLCGR RELVQLPVPSRLHRSPLPT*GRPLPLAALPTRG RLQRRPPWLPLHLPRELHGPAVPDAGGLVQPPA LSKRGSLRPDWGLLPLSPWMERTPL*HPKLALQG GRSPDRGAAGAAVSGGWAVCG*RQLPLLRVPRG PYW*PL*AGGGPLLGPALPAWGDLPWLYGGLHV *VSSWLQW**L*GRRGRVCLPALPARGFMH*PRG PLSLLLSPRNAGGALRD**G*LRPRPTAGLRAP VPTQWHLRGPGGWFPLHLSPRIHWFALRGRHQ* VSLRCLPRGTHPGLPAGPRRRFPLPLSCWLLRSS LSDCPVSLRVPAMPAWRPVPS*PGSWGWADLHL SLCPAVLGSALRAGGALLPGAAVPGGRPMPADA PRAALRLPPRVVGTLLPQLPGVAAGGQQRQLRGR PLSPRGLLPPRAARALLPLRLRAGLDRAALRGA RRGTRGLGGAAVPARRLPGQARGPALRPRVQQP RLRLGRRRLLAERGRPLAAMRGAAVLAPLQQQPL RPRLQLARLPLRQLRLPRRWPRAHLQPGVREVL RRPLCRRPLRPGLQHGGVRLGWAGLCQRGAGPA GPRRAGAHSAAAARGATAFQRRLSAAAQRHPAHL AALPPGRARPGHGLPLPPA*SWLRTPGPSGAGP RGDRLGSNAGD*QPALPAVA*E*SLLPRCPERR *LPGSVVSGGAPGLPVPTAGRAGGAAGASRTQRP AAATASGGRCLAAGHSRPGCHGGPAQARAQHPL VP*GLLTAQGRGLWSQGPAGTRGPGRAGHEEHG QG*EPDGGGGHRLDGHRVPRGQAAKGRGARHGG* GGCGLPSVDSTPSGCC*HPRGTSHGTDTTTGRR RC*WHGCQCAWPRWLHPANAGFLLWGGSGANAN *RG*GR*HIS*HHLRPDLPGGSAWGTD*PYWRDC FAPGCPLCPC*CSQAAAGCWGRHQCPGPLRPHS PAHSCHSRCPGCLPDSHPKPLYRLGCPHGRWLN GTDPGGPPGSRGHGGRAHRQPC*CQCCG*AWEIS LTLGCGCEQRGSHFGPAQKWSQ*GHAG*QGGDP PIPGRPRGQL*GCQAAVGPLCQP*DHRPPGQAA AGRSPGETAPGHRALAGSTQWAPQPPRSPRPGAS ALSSRGLPPWPQSGTVGVQEEQEAPREGGAGAA GAPGAGQEADAGLPGPPG*QLGHAVARGLAGLP AAFRWAPCFPWWLPP*GALCSCHCHCSVSGTAWW PRPGGSRAPAPWRMCTQPGPAEPCGCAPRLGPA APTCPSRPLVPAATGAGTPAAQPRDPRLPAGAA PALPGSPRTWRGVPGGWGTQQPPKGPLPAGSQ*A PLPDPIPRIP*ALGQPLTSLPLRLVRIHA*PSH CHWGHGHHHWGTACPATSLVCSQLPCSGPDPAG APAGSYPQEASVGLRRSSVLRSWGPKETPVLPPF FLCLFLPFSLFHPLLFPPTLLHPCLAA*PR*VI SPGLQSSFIYNGWGLPPTLSVL*RVWDLLLPHF SLPSFLSLSFWPLISLHSDMNELLLFLFFFFFLH FV*KQIHLNKLIIIIFYKIYIWRCSLPL*TPQC PRGAESVGPFGQAGFCVPSTQA*LGSRVPSTRP RYVPSRHPWAHPLGPGVGGVLGASSPPHLPHFTA FQMGHVP*PCWGRAHCQLPLPQPHPWPSPFGN* GAAGGKWEPGQMYAFLCVPVNVGLQEEELPEWY FLFLVILWPSLMAE*RYF*AIFVIWLLVKIPV*L NSQALHCTAPHSPHHLIKE*LTLSVVGLCLGKV GSGGSGTSISPTQG*LELPSWGKYI*LASLLML PLLADDYRLD*WLSPDLS*ANQILLLENFL*WRG *ESCQLVELLRSQSDLEISVANSRWWAKRQANR AEE*S*YSGRIRNESSNGSLRAGGVISAPSAVI NSS*LSVHSIEINRYLLIAF*VSDHGSA*ISLLL HAPMGFGDNLGPM**ILLYLC

Frame 1

RRGGWPGTRPEPREGGRRGGSRPAAMGPGARGR RRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAP PCLDGSPCANGGRCTQLPSREAACLCPPGWVGER CQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC PRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGR FLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCL NTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRN GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCP GHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDV DECQLQPNACHNGGTCFNTLGGHSCVCVNGWTG ESCSQNIDDCATAVCFHGATCHDRVASFYCACP MGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRA ICTCPPGFTGGACDQDVDECSIGANPCEHLGRC VNTQGSFLCQCGRGYTGPRCETDVNECLSGPCR NQATCLDRIGQFTCICMAGFTGTYCEVDIDECQS SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV DECASTPCRNGAKCVDQPDGYECRCAEGFEGTL CDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYT GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC PSGTTGVNCEVNIDDCASNPCTFGVCRDGINRY DCVCQPGFTGPLCNVEINECASSPCGEGGSCVDG ENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI CYDAPGGFRCVCEPGWSGPRCSQSLARDACESQ PCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC TPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY TGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSC LPGFAGPRCARDVDECLSNPCGPGTCTDHVASF TCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVD GVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGG VCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQP CQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCR EAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG RTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMC ECLPGYNGDNCEDDVDECASQPCQHGGSCIDLV ARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPR CLHNGTCVDLVGGFRCTCPPGYTGLRCEADINE CRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGP RCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC HCAQPFWGPRCERVARSCRELQCPVGVPCQQTP RGPRCACPPGLSGPSCRSFPGSPPGASNASCAA APCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAP AAAPEVSEEPRCPRAACQAKRGDQRCDRECNSP GCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSR CDPACSSPACLYDNFDCHAGGRERTCNPVYEKYC ADHFADGRCDQGCNTEECGWDGLDCASEVPALL ARGVLVLTVLLPPEELLRSSADFLQRLSAILRT SLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAP EVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAA DYLGALSAVERLDFPYPLRDVRGEPLEPPEPSV PLLPLLVAGAVLLLVILVLGVMVARRKREHSTLW FPEGFSLHKDVASGHKGRREPVGQDALGMKNMA KGESLMGEVATDWMDTECPEAKRLKVEEPGMGA EEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDA DADGMDVNVRGPDGFTPLMLASFCGGALEPMPT EEDEADDTSASIISDLICQGAQLGARTDRTGET ALHLAARYARADAAKRLLDAGADTNAQDHSGRTP LHTAVTADAQGVFQILIRNRSTDLDARMADGST ALILAARLAVEGMVEELIASHADVNAVDELGKS ALHWAAAVNNVEATLALLKNGANKDMQDSKEETP LFLAAREGSYEAAKLLLDHFANREITDHLDRLP RDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGP LLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQ GPRGRGKKLTLACPGPLADSSVTLSPVDSLDSP RPFGGPPASPGGFPLEGPYAAATATAVSLAQLG GPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARL PPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERP PPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSE HPYLTPSPESPEHWASPSPPSLSDWSESTPSPAT ATGAMATTTGALPAQPLPLSVPSSLAQAQTQLG PQPEVTPKRQVLA*DARQFLDLGGLKRPPSCLL SFSVSSFLLVFFILFSFHQPSCILALQRDRDRSS AQGFSLPLFIMGGGYHPPSQSCEESGTSFFPTS LFPHSFLSPSGLSFPYTLT*MNYYYFYFSFFFY ILYRNKFI*TNLLLLFFTKYIYGDAPSPCEPPSA PVGLSLWAHSAKLDSVYLVHRHDWDPVYRVHDP GMYQVGTLGRTHWGQGSGECWEPPPHPTSLTSL HSRWDMFHSLAGEGPTANSLCPSPTLGHLPLGTR GLLVGNGSQGRCMHSFVSL*MWDYKKRSCLSGT FSSW*SSGPASWQNRGIFRLFL*YGFWSKSLCS *IPKPCIVQPPTPLTT**RNS*HSVLLVCV*VRW GVVAVGLLSPPPRANLSSHLGVNTFDLPVYLCF LFWQMTTDWISGCHLT*AEPIRFFCSRTFFNGE AKKVVSWWSS*GHNQI*KYQWPIRGGGQRDKQTG QKNEANIQGESEMRAQMAP*GLGGLSRLPVQLS IPVN*VFIPLRSTGIY*LLSKYLIMVLHEFHFY FMLLWVLEITLDPCNKYFFTCA

Frame 2

GAEAGPGRARSPGKEGGGEGRGRPPWGRGPVAA AAAVARCRRHRHRHPCGRCPCCCC*RGRGLQPP LAWTEARVQMEVVAPSCPPGRLPACARLAGWVS GVSWRTPVTQAPVLAVVSARVQWWLAPPDSHAGA PVASEALTAPCQIPASAALVPTVPAAQWGPMDA SSAPAHLATRAAAAEATWMSAGWVSPAAMVAPA STHLAPSAASVQLATQGHYVRTPRCPVHPHHAVT GAPAGRVATSLTTVPVFLGLRVRIVK*TWTTVQ DTDVSMGGHAWMASTPITASALLSGQASSARRT WMSVSCSPTPATMGVPASTRWVATAACVSMAGQA RAAVRISMTVPQPCASMGPPAMTAWLLSTVPAP WARLASCVTWMTPVSATPATRMLSVTQIR*TAG PFAPVLPASRVGHVTRMWTSALSAPTPASTWAGA *TRRAPSCASAVVATLDLAVRPMSTSVCRGPAE TRPRASTA*ASSPVSVWQASQEPIARWTLTSVR VAPVSTVGSARTESMASAAPAPRASAAPRVSWTW TNAPARPAGMAPNAWTSPMATSAAVPRALRARC VIATWTTAPLTHATMVAAWMASPASHVPVLLAT RAHAARARWTNAAASPAAMAANA*TWWTSTSAAA LLGPQV*TAK*TLTTVPATPAPLESAVMASTAT TVSANLASQGPFVTWRSMSVLPAHAAREVPVWM GKMASAASARLAPCPHSASPRAIPVPMSPAVTAS AMMHLAGSAVCVSLAGVAPAAARAWPETPVSPS RAGPVGHAAAMEWVSTAPARLVSRDVSVNSSPP APRTPVSMGAAASLPLASCLSAPAPRAGKAHDAS RMWTSVLAPHPVALMVSAPTWQGVSAAPAMEGT LALPAIRTSMTVTPTHA*TVARAKTAWAPFPAP ASLVSPAHDAPAMWMSA*ATPAARAPVPTTWPPS PAPARQATEASTANRTCPTAAPAPASMAGPVWT A*TRSAACAVPATQEPTANMRQTPASRGPAYTG ASAAPPTLASAAPASRASRARSARRWWIGAAASL VKTGVAASRLGPIAFVPLDGADASVTSEACPAG RPQPRSGCGWSSCVRRVGSVWMKTAPTTACAQR AVLVATVSRRWTPAWPSPASMGGPAVAIWGATCV SVFLATMVITVRTTWTSVPPSPASTGVHALTSW PAISAPVPQERWGCSARLMRMTAAQAHRWTQGP GAYTMAPAWTWWVVSAAPVPQDTLVCAARQTSMS VAQVPATRHTPGTACRTQAEVSVAFVMLASQVL AVRLSCLPASPSHASMEASAVLARVLGVG*PSP VTVPSRSGVRVASGWRAPAGSCSARWASHASRRP AGRAAPAPQGCRDPPAAASRGRRRGPATPAARP PPVSTGAPAAPRRSRPSSAALARRAGPGRAARR PPRHPRSRRSRGARAPPARPSAGTSAATASATAQ AAAGTAATAR*AWATPGGNARRCSAGASSTTAA ATPPAARPPASTTTSTATPVAASALATRCTRST APTTLPTAAATRAATRRSAAGMGWIVPARCRPCW PAACWCSQCCCRQRSYCVPAPTFCSGSAPSCAP RCASAWTRTARPWSSLTTGLVLAPNPGPVGSWP PR*SAR**CWRLTTGSACSRLRMITASPMPRAPL TTWERCQRWSAWTSRTHCGTCGGSRWSLQNPAS RCCHC*WRALSCCWSFSSWVSWWPGASASTAPS GSLRASHCTRTWPLVTRAGGNPWARTRWA*RTWP RVRA*WGRWPQTGWTQSAQRPSG*R*RSQAWGL RRLWIAVSGLNTIWLLLTSAWHQPWH*HHHRAT QMLMAWMSMCVAQMASPR*CWLPSVGGLWSQCQL KRMRQMTHQLASSPT*SARGLSLGHGLTVLARL LCTWLPVMPVLMQPSGCWMLGQTPMPRTTQAAL PCTQLSQPMPRVSSRFSSETALQTWMPAWQMAQR H*SWRPAWQ*RAWWKSSSPAMLMSMLWMSLGNQ PYTGLRL*TTWKPLWPCSKMEPIRTCRIARRRP PYSWPPARAAMRLPSCCWTTLPTVRSPTTWTGCR GT*PRRDCTRTSCACWINPVGPAAPPVPTAWGL CSVLQGPSSLASKRHSRGPRRAGGPPGRRGWGR RGPGGGARS*RWPARAPWLTARSRCRPWTRWTPR GLSVGPLLPLVASPLRGPMQLPLPLQCLWHSLV AQAGRV*GASPLEDVYSAWAC*TLWLCPSIGPG CPHLPLQAPRSCCHWRRDPSCSTQGPPSPRRSGP RLTWQSQDMARSTRRLGHTAAPQRPASCGFPVS TLT*PHPPNPLSTGPAPHLPPSQTGPNPRLAQP LPLGPWPPPLGHCLPSHFPCLFPAPLLRPRPSWG PSRKLPPRGKCWPETLVSS*ILGA*RDPRPASF LSLSLPSF*SFSSSSLSTNPPASLPCSVTEIGH QPRASVFLYL*WVGATTHPLSLVKSLGPPSSPLL SSLIPFSLLLASHFLTL*HE*IIIIFIFLFFFT FCIETNSFKQTYYYYFLQNIYMEMLPPPVNPPV PPWG*VCGPIRPSWILCT*YTGMTGIPCTEYTTQ VCTK*APLGAPTGARGRGSVGSLLPTPPPSLHC IPDGTCSIALLGKGPLPTPSAPAPPLAISLWEL GGCWWEMGARADVCIPLCPCKCGTTRRGAA*VVL SLPGNPLAQPHGRIEVFLGYFCNMASGQNPCVA EFPSPALYSPPLPSPPNKGIVNTQCCWSVSR*G GEWWQWDFYLPHPGLT*APILG*IHLTCQSTYAS SFGR*LPIGLVVVT*LKLSQSDSFARELSLMER LRKLSVGGALKVTIRFRNISGQFEVVGKETSKQ GRRMKLIFRENQK*ELKWLLEGWGGYLGSQCSYQ FQLIECSFH*DQQVFINCFLSI*SWFCMNFTFT SCSYGFWR*PWTHVINTSLLVP