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Sequences

Sequence TP73L.eAug05

TTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTT
TTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACA
AGATTGAGATTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGA
CCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCC
ACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCA
AGTCGGCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCTCCTCA
GGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTGAGCCGTGAATTCAAC
GAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCCATCACAGGAAGACAGAGTGTGCTGG
TACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAACAGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAAT
TTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGCTTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCG
GATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGA
CATCCATCAAGAAACGAAGATCCCCAGATGATGAACTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCT
GGAACTCATGCAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAG
TCTCCATCTTCATATGGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCA
ACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACAGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGCA
TCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCG
GGGTGAGCGTGTTATTGATGCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGACTTCAACTTTGACATGGATGCT
CGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAGTGAGCCTCACCATGTGAGCTCTTCCTATCCCTCTCCTAACTGCCAGCCCCCTAAAAGCACT
CCTGCTTAATCTTCAAAGCCTTCTCCCTAGCTCCTCCCCTTCCTCTTGTCTGATTTCTTAGGGGAAGGAGAAGTAAGAGGCTACCTCTTACCTAACATCT
GACCTGGCATCTAATTCTGATTCTGGCTTTAAGCCTTCAAAACTATAGCTTGCAGAACTGTAGCTGCCATGGCTAGGTAGAAGTGAGCAAAAAAGAGTTG
GGTGTCTCCTTAAGCTGCAGAGATTTCTCATTGACTTTTATAAAGCATGTTCACCCTTATAGTCTAAGACTATATATATAAATGTATAAATATACAGTAT
AGATTTTTGGGTGGGGGGCATTGAGTATTGTTTAAAATGTAATTTAAATGAAAGAAAATTGAGTTGCACTTATTGACCATTTTTTAATTTACTTGTTTTG
GATGGCTTGTCTATACTCCTTCCCTTAAGGGGTATCATGTATGGTGATAGGTATCTAGAGCTTAATGCTACATGTGAGTGACGATGATGTACAGATTCTT
TCAGTTCTTTGGATTCTAAATACATGCCACATCAAACCTTTGAGTAGATCCATTTCCATTGCTTATTATGTAGGTAAGACTGTAGATATGTATTCTTTTC
TCAGTGTTGGTATATTTTATATTACTGACATTTCTTCTAGTGATGATGGTTCACGTTGGGGTGATTTAATCCAGTTATAAGAAGAAGTTCATGTCCAAAC
GTCCTCTTTAGTTTTTGGTTGGGAATGAGGAAAATTCTTAAAAGGCCCATAGCAGCCAGTTCAAAAACACCCGACGTCATGTATTTGAGCATATCAGTAA
CCCCCTTAAATTTAATACCAGATACCTTATCTTACAATATTGATTGGGAAAACATTTGCTGCCATTACAGAGGTATTAAAACTAAATTTCACTACTAGAT
TGACTAACTCAAATACACATTTGCTACTGTTGTAAGAATTCTGATTGATTTGATTGGGATGAATGCCATCTATCTAGTTCTAACAGTGAAGTTTTACTGT
CTATTAATATTCAGGGTAAATAGGAATCATTCAGAAATGTTGAGTCTGTACTAAACAGTAAGATATCTCAATGAACCATAAATTCAACTTTGTAAAAATC
TTTTGAAGCATAGATAATATTGTTTGGTAAATGTTTCTTTTGTTTGGTAAATGTTTCTTTTAAAGACCCTCCTATTCTATAAAACTCTGCATGTAGAGGC
TTGTTTACCTTTCTCTCTCTAAGGTTTACAATAGGAGTGGTGATTTGAAAAATATAAAATTATGAGATTGGTTTTCCTGTGGCATAAATTGCATCACTGT
ATCATTTTCTTTTTTAACCGGTAAGAGTTTCAGTTTGTTGGAAAGTAACTGTGAGAACCCAGTTTCCCGTCCATCTCCCTTAGGGACTACCCATAGACAT
GAAAGGTCCCCACAGAGCAAGAGATAAGTCTTTCATGGCTGCTGTTGCTTAAACCACTTAAACGAAGAGTTCCCTTGAAACTTTGGGAAAACATGTTAAT
GACAATATTCCAGATCTTTCAGAAATATAACACATTTTTTTGCATGCATGCAAATGAGCTCTGAAATCTTCCCATGCATTCTGGTCAAGGGCTGTCATTG
CACATAAGCTTCCATTTTAATTTTAAAGTGCAAAAGGGCCAGCGTGGCTCTAAAAGGTAATGTGTGGATTGCCTCTGAAAAGTGTGTATATATTTTGTGT
GAAATTGCATACTTTGTATTTTGATTATTTTTTTTTTCTTCTTGGGATAGTGGGATTTCCAGAACCACACTTGAAACCTTTTTTTATCGTTTTTGTATTT
TCATGAAAATACCATTTAGTAAGAATACCACATCAAATAAGAAATAATGCTACAATTTTAAGAGGGGAGGGAAGGGAAAGTTTTTTTTTATTATTTTTTT
AAAATTTTGTATGTTAAAGAGAATGAGTCCTTGATTTCAAAGTTTTGTTGTACTTAAATGGTAATAAGCACTGTAAACTTCTGCAACAAGCATGCAGCTT
TGCAAACCCATTAAGGGGAAGAATGAAAGCTGTTCCTTGGTCCTAGTAAGAAGACAAACTGCTTCCCTTACTTTGCTGAGGGTTTGAATAAACCTAGGAC
TTCCGAGCTATGTCAGTACTATTCAGGTAACACTAGGGCCTTGGAAATTCCTGTACTGTGTCTCATGGATTTGGCACTAGCCAAAGCGAGGCACCCTTAC
TGGCTTACCTCCTCATGGCAGCCTACTCTCCTTGAGTGTATGAGTAGCCAGGGTAAGGGGTAAAAGGATAGTAAGCATAGAAACCACTAGAAAGTGGGCT
TAATGGAGTTCTTGTGGCCTCAGCTCAATGCAGTTAGCTGAAGAATTGAAAAGTTTTTGTTTGGAGACGTTTATAAACAGAAATGGAAAGCAGAGTTTTC
ATTAAATCCTTTTACCTTTTTTTTTTCTTGGTAATCCCCTAAAATAACAGTATGTGGGATATTGAATGTTAAAGGGATATTTTTTTCTATTATTTTTATA
ATTGTACAAAATTAAGCAAATGTTAAAAGTTTTATATGCTTTATTAATGTTTTCAAAAGGTATTATACATGTGATACATTTTTTAAGCTTCAGTTGCTTG
TCTTCTGGTACTTTCTGTTATGGGCTTTTGGGGAGCCAGAAGCCAATCTACAATCTCTTTTTGTTTGCCAGGACATGCAATAAAATTTAAAAAATAAATA
AAAACTAATTAAGAAATTGTGTGTGTGTCTATCTGTGTCTGTTTGCCTATTTGTCCAT
  • TP73L.F10 (forward primer)
  • TP73L.R8 (reverse primer)
  • Single exon skipping

Frame 0

FRRNPSSFLLERKLLPIHHVPEHTDK*IPQSRG
FPAYLGFSGTAYMFSSAH*LELCG*TIRRWCDKQ
D*D*HGLYPHAGLGPE*PHVATVHEPGAPEQHG
PADSERLLVHQSL*HRPRAEQRHGALALRTAQL
HLRCSLSITRHPLQHRLPRPAQFRRVLPAVEHRQ
VGHLDVFH*TEETLLPNCKDMPHPDQGDDPTSS
GSCYPRHACLQKS*ARHGGGEAVPQP*AEP*IQ
RGTDCPS*SFDSSRGEQPCPVCRRSHHRKTECAG
TL*ATPGWH*IHDSLVQFHV*QQLCWRDEPPSN
FNHCYSGNQRWASPGPTLL*GPDLCLPRKRQEG
G*R*HQKAASFGQYKER*WYEAPVSSEHTWYPDD
IHQETKIPR**TVILTSEGP*DL*NAVEDQRVP
GTHAVPSSAHN*NVQATATAAAPALTSETDLNT
VSIFIW*QLPTSEQNEQHEQAAFCEPAYQPSAAQ
RPHSYNHS*WHGSQQIWQV*KSLSNFDMRSGRA
SWTTGSSTNSPPLLISCGPQAVPLQSVWAPVRP
GVSVLLMLCDSPSARPSLSHPEMSGMTSTLTWML
AAISNSASKRRGSEPHHVSSSYPSPNCQPPKST
PA*SSKPSP*LLPFLLSDFLGEGEVRGYLLPNI
*PGI*F*FWL*AFKTIACRTVAAMAR*K*AKKSW
VSP*AAEISH*LL*SMFTLIV*DYIYKCINIQY
RFLGGGH*VLFKM*FK*KKIELHLLTIF*FTCF
GWLVYTPSLKGYHVW**VSRA*CYM*VTMMYRFF
QFFGF*IHATSNL*VDPFPLLIM*VRL*ICILF
SVLVYFILLTFLLVMMVHVGVI*SSYKKKFMSK
RPL*FLVGNEENS*KAHSSQFKNTRRHVFEHISN
PLKFNTRYLILQY*LGKHLLPLQRY*N*ISLLD
*LTQIHICYCCKNSD*FDWDECHLSSSNSEVLL
SINIQGK*ESFRNVESVLNSKISQ*TINSTL*KS
FEA*IILFGKCFFCLVNVSFKDPPIL*NSACRG
LFTFLSLRFTIGVVI*KI*NYEIGFPVA*IASL
YHFLF*PVRVSVCWKVTVRTQFPVHLP*GLPIDM
KGPHRARDKSFMAAVA*TT*TKSSLETLGKHVN
DNIPDLSEI*HIFLHACK*ALKSSHAFWSRAVI
AHKLPF*F*SAKGPAWL*KVMCGLPLKSVYIFCV
KLHTLYFDYFFFLLGIVGFPEPHLKPFFIVFVF
S*KYHLVRIPHQIRNNATILRGEGRESFFLLFF
*NFVC*RE*VLDFKVLLYLNGNKHCKLLQQACSF
ANPLRGRMKAVPWS**EDKLLPLLC*GFE*T*D
FRAMSVLFR*H*GLGNSCTVSHGFGTSQSEAPL
LAYLLMAAYSP*VYE*PG*GVKG**A*KPLESGL
NGVLVASAQCS*LKN*KVFVWRRL*TEMESRVF
IKSFYLFFFLVIP*NNSMWDIEC*RDIFFYYFY
NCTKLSKC*KFYMLY*CFQKVLYM*YIF*ASVAC
LLVLSVMGFWGARSQSTISFCLPGHAIKFKK*I
KTN*EIVCVSICVCLPICP

Frame 1

FVETPAHFSWKESYYRSTMSQSTQTNEFLSPEV
FQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMD
QQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSS
TFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTA
KSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQ
GAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN
EGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVL
VPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPI
LIIVTLETRDGQVLGRRCFEARICACPGRDRKA
DEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQM
TSIKKRRSPDDELLYLPVRGRETYEMLLKIKESL
ELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQ
SPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQR
NALTPTTIPDGMGANRSGKSENP*AISTCDLEGH
PGPPAAPRILLPFSSPADPKQCLYSQCGLQ*DP
G*ACY*CCAIHPPPDHLFPTPR*VE*LQL*HGC
SPQ*ATAHQRGGGVSLTM*ALPIPLLTASPLKAL
LLNLQSLLPSSSPSSCLIS*GKEK*EATSYLTS
DLASNSDSGFKPSKL*LAEL*LPWLGRSEQKRV
GCLLKLQRFLIDFYKACSPL*SKTIYINV*IYSI
DFWVGGIEYCLKCNLNERKLSCTY*PFFNLLVL
DGLSILLPLRGIMYGDRYLELNATCE*R*CTDS
FSSLDSKYMPHQTFE*IHFHCLLCR*DCRYVFFS
QCWYILYY*HFF***WFTLG*FNPVIRRSSCPN
VLFSFWLGMRKILKRPIAASSKTPDVMYLSISV
TPLNLIPDTLSYNIDWENICCHYRGIKTKFHY*I
D*LKYTFATVVRILIDLIGMNAIYLVLTVKFYC
LLIFRVNRNHSEMLSLY*TVRYLNEP*IQLCKN
LLKHR*YCLVNVSFVW*MFLLKTLLFYKTLHVEA
CLPFSL*GLQ*EW*FEKYKIMRLVFLWHKLHHC
IIFFFNR*EFQFVGK*L*EPSFPSISLRDYP*T
*KVPTEQEISLSWLLLLKPLKRRVPLKLWENMLM
TIFQIFQKYNTFFCMHANEL*NLPMHSGQGLSL
HISFHFNFKVQKGQRGSKR*CVDCL*KVCIYFV
*NCILCILIIFFFFLG*WDFQNHT*NLFLSFLYF
HENTI**EYHIK*EIMLQF*EGREGKVFFYYFF
KILYVKENESLISKFCCT*MVISTVNFCNKHAA
LQTH*GEE*KLFLGPSKKTNCFPYFAEGLNKPRT
SELCQYYSGNTRALEIPVLCLMDLALAKARHPY
WLTSSWQPTLLECMSSQGKG*KDSKHRNH*KVG
LMEFLWPQLNAVS*RIEKFLFGDVYKQKWKAEFS
LNPFTFFFSW*SPKITVCGILNVKGIFFSIIFI
IVQN*ANVKSFICFINVFKRYYTCDTFFKLQLL
VFWYFLLWAFGEPEANLQSLFVCQDMQ*NLKNK*
KLIKKLCVCLSVSVCLFVH

Frame 2

S*KPQLISLGKKVITDPPCPRAHRQMNSSVQRF
SSISGIFWNSLYVQFSPLT*TLWMNHQKMVRQT
RLRLAWTVSACRTRT*VTPCGHSTRTWGS*TAW
TSRFRTAPRPPVPITQTTRRTASRRPRPTHSPAP
PSMLSLHHPPSPPTPTTQARTVSTCPSSSRAPP
SRPPGRIPLN*RNSTAKLQRHAPSRSR**PHLL
RELLSAPCLSTKKLSTSRRW*SGAPTMS*AVNST
RDRLPLLVI*FE*RGTAMPSM*KIPSQEDRVCW
YLMSHPRLALNSRQSCTISCVTAVVLEG*TAVQ
F*SLLLWKPEMGKSWADAALRPGSVLAQEETGRR
MKIASESSKFRTVQRTVMVRSARFVRTHMVSR*
HPSRNEDPQMMNCYTYQ*GAVRLMKCC*RSKSP
WNSCSTFLSTQLKRTGNSNSSSTSTYFRNRPQYS
LHLHMVTAPHL*TK*TA*TSCLL*ASLSTLSSA
TPSLLQPFLMAWEPTDLASLKIPEQFRHAIWKG
ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETR
GERVIDAVRFTLRQTISFPPRDEWNDFNFDMDA
RRNKQQRIKEEGE*ASPCELFLSLS*LPAP*KH
SCLIFKAFSLAPPLPLV*FLRGRRSKRLPLT*HL
TWHLILILALSLQNYSLQNCSCHG*VEVSKKEL
GVSLSCRDFSLTFIKHVHPYSLRLYI*MYKYTV
*IFGWGALSIV*NVI*MKEN*VALIDHFLIYLFW
MACLYSFP*GVSCMVIGI*SLMLHVSDDDVQIL
SVLWILNTCHIKPLSRSISIAYYVGKTVDMYSF
LSVGIFYITDISSSDDGSRWGDLIQL*EEVHVQT
SSLVFGWE*GKFLKGP*QPVQKHPTSCI*AYQ*
PP*I*YQIPYLTILIGKTFAAITEVLKLNFTTR
LTNSNTHLLLL*EF*LI*LG*MPSI*F*Q*SFTV
Y*YSG*IGIIQKC*VCTKQ*DISMNHKFNFVKI
F*SIDNIVW*MFLLFGKCFF*RPSYSIKLCM*R
LVYLSLSKVYNRSGDLKNIKL*DWFSCGINCITV
SFSFLTGKSFSLLESNCENPVSRPSPLGTTHRH
ERSPQSKR*VFHGCCCLNHLNEEFP*NFGKTC*
*QYSRSFRNITHFFACMQMSSEIFPCILVKGCHC
T*ASILILKCKRASVALKGNVWIASEKCVYILC
EIAYFVF*LFFFSSWDSGISRTTLETFFYRFCI
FMKIPFSKNTTSNKK*CYNFKRGGKGKFFFIIFL
KFCMLKRMSP*FQSFVVLKW**AL*TSATSMQL
CKPIKGKNESCSLVLVRRQTASLTLLRV*INLG
LPSYVSTIQVTLGPWKFLYCVSWIWH*PKRGTLT
GLPPHGSLLSLSV*VARVRGKRIVSIETTRKWA
*WSSCGLSSMQLAEELKSFCLETFINRNGKQSF
H*ILLPFFFLGNPLK*QYVGY*MLKGYFFLLFL*
LYKIKQMLKVLYALLMFSKGIIHVIHFLSFSCL
SSGTFCYGLLGSQKPIYNLFLFARTCNKI*KIN
KN*LRNCVCVYLCLFAYLS

Sequence TP73L.gAug05

AGAGAGAAAGAGAGAGAGGGACTTGAGTTCTGTTATCTTCTTAAGTAGATTCATATTGTAAGGGTCTCGGGGTGGGGGGGTTGGCAAAATCCTGGAGCCA
GAAGAAAGGACAGCAGCATTGATCAATCTTACAGCTAACATGTTGTACCTGGAAAACAATGCCCAGACTCAATTTAGTGAGCCACAGTACACGAACCTGG
GGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCC
CTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTC
CAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGG
TGATGACCCCACCTCCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGA
GCTGAGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCCATCACA
GGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAACAGCAGTTGTGTTGGAG
GGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGCTTTGAGGCCCGGATCTGTGCTTGCCC
AGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAAC
ACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAACTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGT
TGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCA
GAAACAGACCTCAATACAGTCTCCATCTTCATATGGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTT
ATCAACCCTCAGCAGCGCAACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAG
ACATGAATGGACTCAGCCCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCCACAGATTGCAG
CATTGTCAGGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGCATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCC
CTTCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATTGATGCTGTGCGATTCACCCT
CCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGACTTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGG
GAGTGAGCCTCACCATGTGAGCTCTTCCTATCCCTCTCCTAACTGCCAGCCCCCTAAAAGCACTCCTGCTTAATCTTCAAAGCCTTCTCCCTAGCTCCTC
CCCTTCCTCTTGTCTGATTTCTTAGGGGAAGGAGAAGTAAGAGGCTACCTCTTACCTAACATCTGACCTGGCATCTAATTCTGATTCTGGCTTTAAGCCT
TCAAAACTATAGCTTGCAGAACTGTAGCTGCCATGGCTAGGTAGAAGTGAGCAAAAAAGAGTTGGGTGTCTCCTTAAGCTGCAGAGATTTCTCATTGACT
TTTATAAAGCATGTTCACCCTTATAGTCTAAGACTATATATATAAATGTATAAATATACAGTATAGATTTTTGGGTGGGGGGCATTGAGTATTGTTTAAA
ATGTAATTTAAATGAAAGAAAATTGAGTTGCACTTATTGACCATTTTTTAATTTACTTGTTTTGGATGGCTTGTCTATACTCCTTCCCTTAAGGGGTATC
ATGTATGGTGATAGGTATCTAGAGCTTAATGCTACATGTGAGTGACGATGATGTACAGATTCTTTCAGTTCTTTGGATTCTAAATACATGCCACATCAAA
CCTTTGAGTAGATCCATTTCCATTGCTTATTATGTAGGTAAGACTGTAGATATGTATTCTTTTCTCAGTGTTGGTATATTTTATATTACTGACATTTCTT
CTAGTGATGATGGTTCACGTTGGGGTGATTTAATCCAGTTATAAGAAGAAGTTCATGTCCAAACGTCCTCTTTAGTTTTTGGTTGGGAATGAGGAAAATT
CTTAAAAGGCCCATAGCAGCCAGTTCAAAAACACCCGACGTCATGTATTTGAGCATATCAGTAACCCCCTTAAATTTAATACCAGATACCTTATCTTACA
ATATTGATTGGGAAAACATTTGCTGCCATTACAGAGGTATTAAAACTAAATTTCACTACTAGATTGACTAACTCAAATACACATTTGCTACTGTTGTAAG
AATTCTGATTGATTTGATTGGGATGAATGCCATCTATCTAGTTCTAACAGTGAAGTTTTACTGTCTATTAATATTCAGGGTAAATAGGAATCATTCAGAA
ATGTTGAGTCTGTACTAAACAGTAAGATATCTCAATGAACCATAAATTCAACTTTGTAAAAATCTTTTGAAGCATAGATAATATTGTTTGGTAAATGTTT
CTTTTGTTTGGTAAATGTTTCTTTTAAAGACCCTCCTATTCTATAAAACTCTGCATGTAGAGGCTTGTTTACCTTTCTCTCTCTAAGGTTTACAATAGGA
GTGGTGATTTGAAAAATATAAAATTATGAGATTGGTTTTCCTGTGGCATAAATTGCATCACTGTATCATTTTCTTTTTTAACCGGTAAGAGTTTCAGTTT
GTTGGAAAGTAACTGTGAGAACCCAGTTTCCCGTCCATCTCCCTTAGGGACTACCCATAGACATGAAAGGTCCCCACAGAGCAAGAGATAAGTCTTTCAT
GGCTGCTGTTGCTTAAACCACTTAAACGAAGAGTTCCCTTGAAACTTTGGGAAAACATGTTAATGACAATATTCCAGATCTTTCAGAAATATAACACATT
TTTTTGCATGCATGCAAATGAGCTCTGAAATCTTCCCATGCATTCTGGTCAAGGGCTGTCATTGCACATAAGCTTCCATTTTAATTTTAAAGTGCAAAAG
GGCCAGCGTGGCTCTAAAAGGTAATGTGTGGATTGCCTCTGAAAAGTGTGTATATATTTTGTGTGAAATTGCATACTTTGTATTTTGATTATTTTTTTTT
TCTTCTTGGGATAGTGGGATTTCCAGAACCACACTTGAAACCTTTTTTTATCGTTTTTGTATTTTCATGAAAATACCATTTAGTAAGAATACCACATCAA
ATAAGAAATAATGCTACAATTTTAAGAGGGGAGGGAAGGGAAAGTTTTTTTTTATTATTTTTTTAAAATTTTGTATGTTAAAGAGAATGAGTCCTTGATT
TCAAAGTTTTGTTGTACTTAAATGGTAATAAGCACTGTAAACTTCTGCAACAAGCATGCAGCTTTGCAAACCCATTAAGGGGAAGAATGAAAGCTGTTCC
TTGGTCCTAGTAAGAAGACAAACTGCTTCCCTTACTTTGCTGAGGGTTTGAATAAACCTAGGACTTCCGAGCTATGTCAGTACTATTCAGGTAACACTAG
GGCCTTGGAAATTCCTGTACTGTGTCTCATGGATTTGGCACTAGCCAAAGCGAGGCACCCTTACTGGCTTACCTCCTCATGGCAGCCTACTCTCCTTGAG
TGTATGAGTAGCCAGGGTAAGGGGTAAAAGGATAGTAAGCATAGAAACCACTAGAAAGTGGGCTTAATGGAGTTCTTGTGGCCTCAGCTCAATGCAGTTA
GCTGAAGAATTGAAAAGTTTTTGTTTGGAGACGTTTATAAACAGAAATGGAAAGCAGAGTTTTCATTAAATCCTTTTACCTTTTTTTTTTCTTGGTAATC
CCCTAAAATAACAGTATGTGGGATATTGAATGTTAAAGGGATATTTTTTTCTATTATTTTTATAATTGTACAAAATTAAGCAAATGTTAAAAGTTTTATA
TGCTTTATTAATGTTTTCAAAAGGTATTATACATGTGATACATTTTTTAAGCTTCAGTTGCTTGTCTTCTGGTACTTTCTGTTATGGGCTTTTGGGGAGC
CAGAAGCCAATCTACAATCTCTTTTTGTTTGCCAGGACATGCAATAAAATTTAAAAAATAAATAAAAACTAATTAAGAAATTGTGTGTGTGTCTATCTGT
GTCTGTTTGCCTATTTGTCCAT
  • TP73L.F10 (forward primer)
  • TP73L.R8 (reverse primer)
  • Single exon skipping

Frame 0

REKEREGLEFCYLLK*IHIVRVSGWGGWQNPGA
RRKDSSIDQSYS*HVVPGKQCPDSI**ATVHEPG
APEQHGPADSERLLVHQSL*HRPRAEQRHGALA
LRTAQLHLRCSLSITRHPLQHRLPRPAQFRRVL
PAVEHRQVGHLDVFH*TEETLLPNCKDMPHPDQG
DDPTSSGSCYPRHACLQKS*ARHGGGEAVPQP*
AEP*IQRGTDCPS*SFDSSRGEQPCPVCRRSHH
RKTECAGTL*ATPGWH*IHDSLVQFHV*QQLCWR
DEPPSNFNHCYSGNQRWASPGPTLL*GPDLCLP
RKRQEGG*R*HQKAASFGQYKER*WYEAPVSSE
HTWYPDDIHQETKIPR**TVILTSEGP*DL*NAV
EDQRVPGTHAVPSSAHN*NVQATATAAAPALTS
ETDLNTVSIFIW*QLPTSEQNEQHEQAAFCEPA
YQPSAAQRPHSYNHS*WHGSQHSHDGHPHANGWR
HEWTQPHPGTPSPTLHAIHLPLHTPTSVSHRLQ
HCQDLASLKIPEQFRHAIWKGILDHRQLHEFSS
PSHLLRTPSSASTVSVGSSETRGERVIDAVRFTL
RQTISFPPRDEWNDFNFDMDARRNKQQRIKEEG
E*ASPCELFLSLS*LPAP*KHSCLIFKAFSLAP
PLPLV*FLRGRRSKRLPLT*HLTWHLILILALSL
QNYSLQNCSCHG*VEVSKKELGVSLSCRDFSLT
FIKHVHPYSLRLYI*MYKYTV*IFGWGALSIV*
NVI*MKEN*VALIDHFLIYLFWMACLYSFP*GVS
CMVIGI*SLMLHVSDDDVQILSVLWILNTCHIK
PLSRSISIAYYVGKTVDMYSFLSVGIFYITDIS
SSDDGSRWGDLIQL*EEVHVQTSSLVFGWE*GKF
LKGP*QPVQKHPTSCI*AYQ*PP*I*YQIPYLT
ILIGKTFAAITEVLKLNFTTRLTNSNTHLLLL*
EF*LI*LG*MPSI*F*Q*SFTVY*YSG*IGIIQK
C*VCTKQ*DISMNHKFNFVKIF*SIDNIVW*MF
LLFGKCFF*RPSYSIKLCM*RLVYLSLSKVYNR
SGDLKNIKL*DWFSCGINCITVSFSFLTGKSFSL
LESNCENPVSRPSPLGTTHRHERSPQSKR*VFH
GCCCLNHLNEEFP*NFGKTC**QYSRSFRNITH
FFACMQMSSEIFPCILVKGCHCT*ASILILKCKR
ASVALKGNVWIASEKCVYILCEIAYFVF*LFFF
SSWDSGISRTTLETFFYRFCIFMKIPFSKNTTS
NKK*CYNFKRGGKGKFFFIIFLKFCMLKRMSP*F
QSFVVLKW**AL*TSATSMQLCKPIKGKNESCS
LVLVRRQTASLTLLRV*INLGLPSYVSTIQVTL
GPWKFLYCVSWIWH*PKRGTLTGLPPHGSLLSLS
V*VARVRGKRIVSIETTRKWA*WSSCGLSSMQL
AEELKSFCLETFINRNGKQSFH*ILLPFFFLGN
PLK*QYVGY*MLKGYFFLLFL*LYKIKQMLKVLY
ALLMFSKGIIHVIHFLSFSCLSSGTFCYGLLGS
QKPIYNLFLFARTCNKI*KINKN*LRNCVCVYL
CLFAYLS

Frame 1

ERKRERDLSSVIFLSRFIL*GSRGGGVGKILEP
EERTAALINLTANMLYLENNAQTQFSEPQYTNL
GLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSP
YAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSF
QQSSTAKSATWTYSTELKKLYCQIAKTCPIQIK
VMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHE
LSREFNEGQIAPPSHLIRVEGNSHAQYVEDPIT
GRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVG
GMNRRPILIIVTLETRDGQVLGRRCFEARICACP
GRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQN
THGIQMTSIKKRRSPDDELLYLPVRGRETYEML
LKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQ
KQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQL
INPQQRNALTPTTIPDGMGANIPMMGTHMPMAG
DMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCS
IVRIWQV*KSLSNFDMRSGRASWTTGSSTNSPP
LLISCGPQAVPLQSVWAPVRPGVSVLLMLCDSP
SARPSLSHPEMSGMTSTLTWMLAAISNSASKRRG
SEPHHVSSSYPSPNCQPPKSTPA*SSKPSP*LL
PFLLSDFLGEGEVRGYLLPNI*PGI*F*FWL*A
FKTIACRTVAAMAR*K*AKKSWVSP*AAEISH*L
L*SMFTLIV*DYIYKCINIQYRFLGGGH*VLFK
M*FK*KKIELHLLTIF*FTCFGWLVYTPSLKGY
HVW**VSRA*CYM*VTMMYRFFQFFGF*IHATSN
L*VDPFPLLIM*VRL*ICILFSVLVYFILLTFL
LVMMVHVGVI*SSYKKKFMSKRPL*FLVGNEEN
S*KAHSSQFKNTRRHVFEHISNPLKFNTRYLILQ
Y*LGKHLLPLQRY*N*ISLLD*LTQIHICYCCK
NSD*FDWDECHLSSSNSEVLLSINIQGK*ESFR
NVESVLNSKISQ*TINSTL*KSFEA*IILFGKCF
FCLVNVSFKDPPIL*NSACRGLFTFLSLRFTIG
VVI*KI*NYEIGFPVA*IASLYHFLF*PVRVSV
CWKVTVRTQFPVHLP*GLPIDMKGPHRARDKSFM
AAVA*TT*TKSSLETLGKHVNDNIPDLSEI*HI
FLHACK*ALKSSHAFWSRAVIAHKLPF*F*SAK
GPAWL*KVMCGLPLKSVYIFCVKLHTLYFDYFFF
LLGIVGFPEPHLKPFFIVFVFS*KYHLVRIPHQ
IRNNATILRGEGRESFFLLFF*NFVC*RE*VLD
FKVLLYLNGNKHCKLLQQACSFANPLRGRMKAVP
WS**EDKLLPLLC*GFE*T*DFRAMSVLFR*H*
GLGNSCTVSHGFGTSQSEAPLLAYLLMAAYSP*
VYE*PG*GVKG**A*KPLESGLNGVLVASAQCS*
LKN*KVFVWRRL*TEMESRVFIKSFYLFFFLVI
P*NNSMWDIEC*RDIFFYYFYNCTKLSKC*KFY
MLY*CFQKVLYM*YIF*ASVACLLVLSVMGFWGA
RSQSTISFCLPGHAIKFKK*IKTN*EIVCVSIC
VCLPICP

Frame 2

RERERGT*VLLSS*VDSYCKGLGVGGLAKSWSQ
KKGQQH*SILQLTCCTWKTMPRLNLVSHSTRTW
GS*TAWTSRFRTAPRPPVPITQTTRRTASRRPR
PTHSPAPPSMLSLHHPPSPPTPTTQARTVSTCPS
SSRAPPSRPPGRIPLN*RNSTAKLQRHAPSRSR
**PHLLRELLSAPCLSTKKLSTSRRW*SGAPTM
S*AVNSTRDRLPLLVI*FE*RGTAMPSM*KIPSQ
EDRVCWYLMSHPRLALNSRQSCTISCVTAVVLE
G*TAVQF*SLLLWKPEMGKSWADAALRPGSVLA
QEETGRRMKIASESSKFRTVQRTVMVRSARFVRT
HMVSR*HPSRNEDPQMMNCYTYQ*GAVRLMKCC
*RSKSPWNSCSTFLSTQLKRTGNSNSSSTSTYF
RNRPQYSLHLHMVTAPHL*TK*TA*TSCLL*ASL
STLSSATPSLLQPFLMAWEPTFP*WAPTCQWLE
T*MDSAPPRHSLPHSPCHPPPTAHPHLRIPQIA
ALSGSGKSENP*AISTCDLEGHPGPPAAPRILLP
FSSPADPKQCLYSQCGLQ*DPG*ACY*CCAIHP
PPDHLFPTPR*VE*LQL*HGCSPQ*ATAHQRGG
GVSLTM*ALPIPLLTASPLKALLLNLQSLLPSSS
PSSCLIS*GKEK*EATSYLTSDLASNSDSGFKP
SKL*LAEL*LPWLGRSEQKRVGCLLKLQRFLID
FYKACSPL*SKTIYINV*IYSIDFWVGGIEYCLK
CNLNERKLSCTY*PFFNLLVLDGLSILLPLRGI
MYGDRYLELNATCE*R*CTDSFSSLDSKYMPHQ
TFE*IHFHCLLCR*DCRYVFFSQCWYILYY*HFF
***WFTLG*FNPVIRRSSCPNVLFSFWLGMRKI
LKRPIAASSKTPDVMYLSISVTPLNLIPDTLSY
NIDWENICCHYRGIKTKFHY*ID*LKYTFATVVR
ILIDLIGMNAIYLVLTVKFYCLLIFRVNRNHSE
MLSLY*TVRYLNEP*IQLCKNLLKHR*YCLVNV
SFVW*MFLLKTLLFYKTLHVEACLPFSL*GLQ*E
W*FEKYKIMRLVFLWHKLHHCIIFFFNR*EFQF
VGK*L*EPSFPSISLRDYP*T*KVPTEQEISLS
WLLLLKPLKRRVPLKLWENMLMTIFQIFQKYNTF
FCMHANEL*NLPMHSGQGLSLHISFHFNFKVQK
GQRGSKR*CVDCL*KVCIYFV*NCILCILIIFF
FFLG*WDFQNHT*NLFLSFLYFHENTI**EYHIK
*EIMLQF*EGREGKVFFYYFFKILYVKENESLI
SKFCCT*MVISTVNFCNKHAALQTH*GEE*KLF
LGPSKKTNCFPYFAEGLNKPRTSELCQYYSGNTR
ALEIPVLCLMDLALAKARHPYWLTSSWQPTLLE
CMSSQGKG*KDSKHRNH*KVGLMEFLWPQLNAV
S*RIEKFLFGDVYKQKWKAEFSLNPFTFFFSW*S
PKITVCGILNVKGIFFSIIFIIVQN*ANVKSFI
CFINVFKRYYTCDTFFKLQLLVFWYFLLWAFGE
PEANLQSLFVCQDMQ*NLKNK*KLIKKLCVCLSV
SVCLFVH

Sequence TP73L.cAug05

TTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTT
TTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACA
AGATTGAGATTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGA
CCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCC
ACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCA
AGTCGGCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCTCCTCA
GGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTGAGCCGTGAATTCAAC
GAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCCATCACAGGAAGACAGAGTGTGCTGG
TACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAACAGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAAT
TTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGCTTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCG
GATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGA
CATCCATCAAGAAACGAAGATCCCCAGATGATGAACTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCT
GGAACTCATGCAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAG
TCTCCATCTTCATATGGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCA
ACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTCAGCCC
CACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCCACAGATTGCAGCATTGTCAGGATCTGGCAA
GTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGCATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGAC
CCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATTGATGCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTC
CCACCCCGAGATGAGTGGAATGACTTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAGTGAGCCTCACCATGTG
AGCTCTTCCTATCCCTCTCCTAACTGCCAGCCCCCTAAAAGCACTCCTGCTTAATCTTCAAAGCCTTCTCCCTAGCTCCTCCCCTTCCTCTTGTCTGATT
TCTTAGGGGAAGGAGAAGTAAGAGGCTACCTCTTACCTAACATCTGACCTGGCATCTAATTCTGATTCTGGCTTTAAGCCTTCAAAACTATAGCTTGCAG
AACTGTAGCTGCCATGGCTAGGTAGAAGTGAGCAAAAAAGAGTTGGGTGTCTCCTTAAGCTGCAGAGATTTCTCATTGACTTTTATAAAGCATGTTCACC
CTTATAGTCTAAGACTATATATATAAATGTATAAATATACAGTATAGATTTTTGGGTGGGGGGCATTGAGTATTGTTTAAAATGTAATTTAAATGAAAGA
AAATTGAGTTGCACTTATTGACCATTTTTTAATTTACTTGTTTTGGATGGCTTGTCTATACTCCTTCCCTTAAGGGGTATCATGTATGGTGATAGGTATC
TAGAGCTTAATGCTACATGTGAGTGACGATGATGTACAGATTCTTTCAGTTCTTTGGATTCTAAATACATGCCACATCAAACCTTTGAGTAGATCCATTT
CCATTGCTTATTATGTAGGTAAGACTGTAGATATGTATTCTTTTCTCAGTGTTGGTATATTTTATATTACTGACATTTCTTCTAGTGATGATGGTTCACG
TTGGGGTGATTTAATCCAGTTATAAGAAGAAGTTCATGTCCAAACGTCCTCTTTAGTTTTTGGTTGGGAATGAGGAAAATTCTTAAAAGGCCCATAGCAG
CCAGTTCAAAAACACCCGACGTCATGTATTTGAGCATATCAGTAACCCCCTTAAATTTAATACCAGATACCTTATCTTACAATATTGATTGGGAAAACAT
TTGCTGCCATTACAGAGGTATTAAAACTAAATTTCACTACTAGATTGACTAACTCAAATACACATTTGCTACTGTTGTAAGAATTCTGATTGATTTGATT
GGGATGAATGCCATCTATCTAGTTCTAACAGTGAAGTTTTACTGTCTATTAATATTCAGGGTAAATAGGAATCATTCAGAAATGTTGAGTCTGTACTAAA
CAGTAAGATATCTCAATGAACCATAAATTCAACTTTGTAAAAATCTTTTGAAGCATAGATAATATTGTTTGGTAAATGTTTCTTTTGTTTGGTAAATGTT
TCTTTTAAAGACCCTCCTATTCTATAAAACTCTGCATGTAGAGGCTTGTTTACCTTTCTCTCTCTAAGGTTTACAATAGGAGTGGTGATTTGAAAAATAT
AAAATTATGAGATTGGTTTTCCTGTGGCATAAATTGCATCACTGTATCATTTTCTTTTTTAACCGGTAAGAGTTTCAGTTTGTTGGAAAGTAACTGTGAG
AACCCAGTTTCCCGTCCATCTCCCTTAGGGACTACCCATAGACATGAAAGGTCCCCACAGAGCAAGAGATAAGTCTTTCATGGCTGCTGTTGCTTAAACC
ACTTAAACGAAGAGTTCCCTTGAAACTTTGGGAAAACATGTTAATGACAATATTCCAGATCTTTCAGAAATATAACACATTTTTTTGCATGCATGCAAAT
GAGCTCTGAAATCTTCCCATGCATTCTGGTCAAGGGCTGTCATTGCACATAAGCTTCCATTTTAATTTTAAAGTGCAAAAGGGCCAGCGTGGCTCTAAAA
GGTAATGTGTGGATTGCCTCTGAAAAGTGTGTATATATTTTGTGTGAAATTGCATACTTTGTATTTTGATTATTTTTTTTTTCTTCTTGGGATAGTGGGA
TTTCCAGAACCACACTTGAAACCTTTTTTTATCGTTTTTGTATTTTCATGAAAATACCATTTAGTAAGAATACCACATCAAATAAGAAATAATGCTACAA
TTTTAAGAGGGGAGGGAAGGGAAAGTTTTTTTTTATTATTTTTTTAAAATTTTGTATGTTAAAGAGAATGAGTCCTTGATTTCAAAGTTTTGTTGTACTT
AAATGGTAATAAGCACTGTAAACTTCTGCAACAAGCATGCAGCTTTGCAAACCCATTAAGGGGAAGAATGAAAGCTGTTCCTTGGTCCTAGTAAGAAGAC
AAACTGCTTCCCTTACTTTGCTGAGGGTTTGAATAAACCTAGGACTTCCGAGCTATGTCAGTACTATTCAGGTAACACTAGGGCCTTGGAAATTCCTGTA
CTGTGTCTCATGGATTTGGCACTAGCCAAAGCGAGGCACCCTTACTGGCTTACCTCCTCATGGCAGCCTACTCTCCTTGAGTGTATGAGTAGCCAGGGTA
AGGGGTAAAAGGATAGTAAGCATAGAAACCACTAGAAAGTGGGCTTAATGGAGTTCTTGTGGCCTCAGCTCAATGCAGTTAGCTGAAGAATTGAAAAGTT
TTTGTTTGGAGACGTTTATAAACAGAAATGGAAAGCAGAGTTTTCATTAAATCCTTTTACCTTTTTTTTTTCTTGGTAATCCCCTAAAATAACAGTATGT
GGGATATTGAATGTTAAAGGGATATTTTTTTCTATTATTTTTATAATTGTACAAAATTAAGCAAATGTTAAAAGTTTTATATGCTTTATTAATGTTTTCA
AAAGGTATTATACATGTGATACATTTTTTAAGCTTCAGTTGCTTGTCTTCTGGTACTTTCTGTTATGGGCTTTTGGGGAGCCAGAAGCCAATCTACAATC
TCTTTTTGTTTGCCAGGACATGCAATAAAATTTAAAAAATAAATAAAAACTAATTAAGAAATTGTGTGTGTGTCTATCTGTGTCTGTTTGCCTATTTGTC
CAT
  • TP73L.F10 (forward primer)
  • TP73L.R8 (reverse primer)
  • Single exon skipping

Frame 0

FRRNPSSFLLERKLLPIHHVPEHTDK*IPQSRG
FPAYLGFSGTAYMFSSAH*LELCG*TIRRWCDKQ
D*D*HGLYPHAGLGPE*PHVATVHEPGAPEQHG
PADSERLLVHQSL*HRPRAEQRHGALALRTAQL
HLRCSLSITRHPLQHRLPRPAQFRRVLPAVEHRQ
VGHLDVFH*TEETLLPNCKDMPHPDQGDDPTSS
GSCYPRHACLQKS*ARHGGGEAVPQP*AEP*IQ
RGTDCPS*SFDSSRGEQPCPVCRRSHHRKTECAG
TL*ATPGWH*IHDSLVQFHV*QQLCWRDEPPSN
FNHCYSGNQRWASPGPTLL*GPDLCLPRKRQEG
G*R*HQKAASFGQYKER*WYEAPVSSEHTWYPDD
IHQETKIPR**TVILTSEGP*DL*NAVEDQRVP
GTHAVPSSAHN*NVQATATAAAPALTSETDLNT
VSIFIW*QLPTSEQNEQHEQAAFCEPAYQPSAAQ
RPHSYNHS*WHGSQHSHDGHPHANGWRHEWTQP
HPGTPSPTLHAIHLPLHTPTSVSHRLQHCQDLA
SLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRT
PSSASTVSVGSSETRGERVIDAVRFTLRQTISF
PPRDEWNDFNFDMDARRNKQQRIKEEGE*ASPC
ELFLSLS*LPAP*KHSCLIFKAFSLAPPLPLV*F
LRGRRSKRLPLT*HLTWHLILILALSLQNYSLQ
NCSCHG*VEVSKKELGVSLSCRDFSLTFIKHVH
PYSLRLYI*MYKYTV*IFGWGALSIV*NVI*MKE
N*VALIDHFLIYLFWMACLYSFP*GVSCMVIGI
*SLMLHVSDDDVQILSVLWILNTCHIKPLSRSI
SIAYYVGKTVDMYSFLSVGIFYITDISSSDDGSR
WGDLIQL*EEVHVQTSSLVFGWE*GKFLKGP*Q
PVQKHPTSCI*AYQ*PP*I*YQIPYLTILIGKT
FAAITEVLKLNFTTRLTNSNTHLLLL*EF*LI*L
G*MPSI*F*Q*SFTVY*YSG*IGIIQKC*VCTK
Q*DISMNHKFNFVKIF*SIDNIVW*MFLLFGKC
FF*RPSYSIKLCM*RLVYLSLSKVYNRSGDLKNI
KL*DWFSCGINCITVSFSFLTGKSFSLLESNCE
NPVSRPSPLGTTHRHERSPQSKR*VFHGCCCLN
HLNEEFP*NFGKTC**QYSRSFRNITHFFACMQM
SSEIFPCILVKGCHCT*ASILILKCKRASVALK
GNVWIASEKCVYILCEIAYFVF*LFFFSSWDSG
ISRTTLETFFYRFCIFMKIPFSKNTTSNKK*CYN
FKRGGKGKFFFIIFLKFCMLKRMSP*FQSFVVL
KW**AL*TSATSMQLCKPIKGKNESCSLVLVRR
QTASLTLLRV*INLGLPSYVSTIQVTLGPWKFLY
CVSWIWH*PKRGTLTGLPPHGSLLSLSV*VARV
RGKRIVSIETTRKWA*WSSCGLSSMQLAEELKS
FCLETFINRNGKQSFH*ILLPFFFLGNPLK*QYV
GY*MLKGYFFLLFL*LYKIKQMLKVLYALLMFS
KGIIHVIHFLSFSCLSSGTFCYGLLGSQKPIYN
LFLFARTCNKI*KINKN*LRNCVCVYLCLFAYLS

Frame 1

FVETPAHFSWKESYYRSTMSQSTQTNEFLSPEV
FQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMD
QQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSS
TFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTA
KSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQ
GAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN
EGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVL
VPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPI
LIIVTLETRDGQVLGRRCFEARICACPGRDRKA
DEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQM
TSIKKRRSPDDELLYLPVRGRETYEMLLKIKESL
ELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQ
SPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQR
NALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSP
TQALPPPLSMPSTSHCTPPPPYPTDCSIVRIWQ
V*KSLSNFDMRSGRASWTTGSSTNSPPLLISCG
PQAVPLQSVWAPVRPGVSVLLMLCDSPSARPSLS
HPEMSGMTSTLTWMLAAISNSASKRRGSEPHHV
SSSYPSPNCQPPKSTPA*SSKPSP*LLPFLLSD
FLGEGEVRGYLLPNI*PGI*F*FWL*AFKTIACR
TVAAMAR*K*AKKSWVSP*AAEISH*LL*SMFT
LIV*DYIYKCINIQYRFLGGGH*VLFKM*FK*K
KIELHLLTIF*FTCFGWLVYTPSLKGYHVW**VS
RA*CYM*VTMMYRFFQFFGF*IHATSNL*VDPF
PLLIM*VRL*ICILFSVLVYFILLTFLLVMMVH
VGVI*SSYKKKFMSKRPL*FLVGNEENS*KAHSS
QFKNTRRHVFEHISNPLKFNTRYLILQY*LGKH
LLPLQRY*N*ISLLD*LTQIHICYCCKNSD*FD
WDECHLSSSNSEVLLSINIQGK*ESFRNVESVLN
SKISQ*TINSTL*KSFEA*IILFGKCFFCLVNV
SFKDPPIL*NSACRGLFTFLSLRFTIGVVI*KI
*NYEIGFPVA*IASLYHFLF*PVRVSVCWKVTVR
TQFPVHLP*GLPIDMKGPHRARDKSFMAAVA*T
T*TKSSLETLGKHVNDNIPDLSEI*HIFLHACK
*ALKSSHAFWSRAVIAHKLPF*F*SAKGPAWL*K
VMCGLPLKSVYIFCVKLHTLYFDYFFFLLGIVG
FPEPHLKPFFIVFVFS*KYHLVRIPHQIRNNAT
ILRGEGRESFFLLFF*NFVC*RE*VLDFKVLLYL
NGNKHCKLLQQACSFANPLRGRMKAVPWS**ED
KLLPLLC*GFE*T*DFRAMSVLFR*H*GLGNSC
TVSHGFGTSQSEAPLLAYLLMAAYSP*VYE*PG*
GVKG**A*KPLESGLNGVLVASAQCS*LKN*KV
FVWRRL*TEMESRVFIKSFYLFFFLVIP*NNSM
WDIEC*RDIFFYYFYNCTKLSKC*KFYMLY*CFQ
KVLYM*YIF*ASVACLLVLSVMGFWGARSQSTI
SFCLPGHAIKFKK*IKTN*EIVCVSICVCLPIC
P

Frame 2

S*KPQLISLGKKVITDPPCPRAHRQMNSSVQRF
SSISGIFWNSLYVQFSPLT*TLWMNHQKMVRQT
RLRLAWTVSACRTRT*VTPCGHSTRTWGS*TAW
TSRFRTAPRPPVPITQTTRRTASRRPRPTHSPAP
PSMLSLHHPPSPPTPTTQARTVSTCPSSSRAPP
SRPPGRIPLN*RNSTAKLQRHAPSRSR**PHLL
RELLSAPCLSTKKLSTSRRW*SGAPTMS*AVNST
RDRLPLLVI*FE*RGTAMPSM*KIPSQEDRVCW
YLMSHPRLALNSRQSCTISCVTAVVLEG*TAVQ
F*SLLLWKPEMGKSWADAALRPGSVLAQEETGRR
MKIASESSKFRTVQRTVMVRSARFVRTHMVSR*
HPSRNEDPQMMNCYTYQ*GAVRLMKCC*RSKSP
WNSCSTFLSTQLKRTGNSNSSSTSTYFRNRPQYS
LHLHMVTAPHL*TK*TA*TSCLL*ASLSTLSSA
TPSLLQPFLMAWEPTFP*WAPTCQWLET*MDSA
PPRHSLPHSPCHPPPTAHPHLRIPQIAALSGSGK
SENP*AISTCDLEGHPGPPAAPRILLPFSSPAD
PKQCLYSQCGLQ*DPG*ACY*CCAIHPPPDHLF
PTPR*VE*LQL*HGCSPQ*ATAHQRGGGVSLTM*
ALPIPLLTASPLKALLLNLQSLLPSSSPSSCLI
S*GKEK*EATSYLTSDLASNSDSGFKPSKL*LA
EL*LPWLGRSEQKRVGCLLKLQRFLIDFYKACSP
L*SKTIYINV*IYSIDFWVGGIEYCLKCNLNER
KLSCTY*PFFNLLVLDGLSILLPLRGIMYGDRY
LELNATCE*R*CTDSFSSLDSKYMPHQTFE*IHF
HCLLCR*DCRYVFFSQCWYILYY*HFF***WFT
LG*FNPVIRRSSCPNVLFSFWLGMRKILKRPIA
ASSKTPDVMYLSISVTPLNLIPDTLSYNIDWENI
CCHYRGIKTKFHY*ID*LKYTFATVVRILIDLI
GMNAIYLVLTVKFYCLLIFRVNRNHSEMLSLY*
TVRYLNEP*IQLCKNLLKHR*YCLVNVSFVW*MF
LLKTLLFYKTLHVEACLPFSL*GLQ*EW*FEKY
KIMRLVFLWHKLHHCIIFFFNR*EFQFVGK*L*
EPSFPSISLRDYP*T*KVPTEQEISLSWLLLLKP
LKRRVPLKLWENMLMTIFQIFQKYNTFFCMHAN
EL*NLPMHSGQGLSLHISFHFNFKVQKGQRGSK
R*CVDCL*KVCIYFV*NCILCILIIFFFFLG*WD
FQNHT*NLFLSFLYFHENTI**EYHIK*EIMLQ
F*EGREGKVFFYYFFKILYVKENESLISKFCCT
*MVISTVNFCNKHAALQTH*GEE*KLFLGPSKKT
NCFPYFAEGLNKPRTSELCQYYSGNTRALEIPV
LCLMDLALAKARHPYWLTSSWQPTLLECMSSQG
KG*KDSKHRNH*KVGLMEFLWPQLNAVS*RIEKF
LFGDVYKQKWKAEFSLNPFTFFFSW*SPKITVC
GILNVKGIFFSIIFIIVQN*ANVKSFICFINVF
KRYYTCDTFFKLQLLVFWYFLLWAFGEPEANLQS
LFVCQDMQ*NLKNK*KLIKKLCVCLSVSVCLFV
H

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