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Sequences

Sequence APP.fAug05

CTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAAC TCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTC CGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAG CAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGA GGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACC ACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTG AAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCC TACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTT GAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTA TCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTC CGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGA CACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGGTGCAGT GGCTCATGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGTGGGCAGATGACTTGAGCCCAGAAGTTCAAGACCAGAATGGGAAACATGGCAAGACCACAT TTCTACAAAAAAATTATCCAGGCATGATAACATCTATTTGTAGTCCCAGCTACTCAGGAGGCTGTGGTGGGAGGATCTCCTGAGCCTGGGGTGGCTGAGG CTGCAGTGAGCCTTGATCACGCCACCTGGGCAATAGAGCAAGACCCTGTCTCAAAAAAAGGAAGAAAAAGACTATTATTTCCCCCATTGAATGGTCTTGG CACTATTACACAAAATCAATTGTCCATAGATAATATGGGTTTATTTCTTAATTCTTAGTTCTTTTCTTTGATCTGTGTGCCTGTGCTTACTGTAGTACCA CACTGTTTTGATTATTGTAGCTTTGTAGTAAATTTTGAAATCAGCAAGTGTGAGTCCGTTATCTTTGTTCTTCTTTTTCAATATTACTTTGAGTATCCGG AGTCTCTTGCATTACAACATGAATTTTAAGATCTTCC

APP.F9 (forward primer)
APP.R1 (reverse primer)
Single exon skipping

Frame 0

LQITNVVEANQPVTIQNWCKRGRKQCKTHPHFV IPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGG ADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDE DDEDGDEVEEEAEEPYEEATERTTSIATTTTTT TESVEEVVREVCSEQAETGPCRAMISRWYFDVT EGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIP TTAASTPDAVDKYLETPGDENEHAHFQKAKERL EAKHRERMSQVMREWEEAERQAKNLPKADKKAV IQHFQEKVESLEQEAANERQQLVETHMARVEAML NDRRRLALENYITALQAVPPRPRHVFNMLKKYV RAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM THLRVIYERMNQSLSLLYNVPAVAEEIQDEVGAV AHACNSSILGGQGGQMT*AQKFKTRMGNMARPH FYKKIIQA**HLFVVPATQEAVVGGSPEPGVAE AAVSLDHATWAIEQDPVSKKGRKRLLFPPLNGLG TITQNQLSIDNMGLFLNS*FFSLICVPVLTVVP HCFDYCSFVVNFEISKCESVIFVLLFQYYFEYP ESLALQHEF*DL

Frame 1

CRSPMW*KPTNQ*PSRTGASGAASSARPIPTL* FPTAA*LVSL*VMPFSFLTSANSYTRRGWMFAK LIFTGTPSPKRHAVRRVPTCMTTACCCPAELTSS EG*SLCVAHWLKKVTMWILLMRRRMTRMSGGAE QTQTMQMGVKTK**K*QRRKKWLRWKKKKPMMT RTMRMVMR*RKRLRNPTKKPQREPPALPPPPPPP QSLWKRWFERCALNKPRRGRAEQ*SPAGTLM*L KGSVPHSFTADVAATGTTLTQKSTAWPCVAAPF LQQQPVPLMPLTSISRHLGMRMNMPISRKPKRGL RPSTERECPRS*ENGKRQNVKQRTCLKLIRRQL SSISRRKWNLWNRKQPTRDSSWWRHTWPEWKPC SMTAAAWPWRTTSPLCRLFLLGLVTCSIC*RSMS AQNRRTDSTP*SISSMCAWWIPRKPLRSGPRL* HTSV*FMSA*ISLSPCSTTCLQWPRRFRMKLVQ WLMPVIPAFWEAKVGR*LEPRSSRPEWETWQDHI STKKLSRHDNIYL*SQLLRRLWWEDLLSLGWLR LQ*ALITPPGQ*SKTLSQKKEEKDYYFPH*MVL ALLHKINCP*IIWVYFLILSSFL*SVCLCLL*YH TVLIIVAL**ILKSASVSPLSLFFFFNITLSIR SLLHYNMNFKIF

Frame 2

ADHQCGRSQPTSDHPELVQAGPQAVQDPSPLCD SLPLLSW*VCK*CPSRS*QVQILTPGEDGCLRN SSSLAHRRQRDMQ*EEYQLA*LRHVAALRN*QV PRGRVCVLPTG*RK*QCGFC*CGGG*LGCLVGRS RHRLCRWE*RQSSRSSRGGRSG*GGRRRSR**R GR*GW**GRGRG*GTLRRSHRENHQHCHHHHHH HRVCGRGGSRGVL*TSRDGAVPSNDLPLVL*CD* REVCPILLRRMWRQPEQL*HRRVLHGRVWQRHS YNSSQYP*CR*QVSRDTWG*E*TCPFPESQREA *GQAPRENVPGHERMGRGRTSSKELA*S**EGSY PAFPGESGIFGTGSSQRETAAGGDTHGQSGSHA Q*PPPPGPGELHHRSAGCSSSASSRVQYAKEVC PRRTEGQTAHPKAFRACAHGGSQESRSDPVPGYD TPPCDL*AHESVSLPALQRACSGRGDSG*SWCS GSCL*FQHFGRPRWADDLSPEVQDQNGKHGKTT FLQKNYPGMITSICSPSYSGGCGGRIS*AWGG*G CSEP*SRHLGNRARPCLKKRKKKTIISPIEWSW HYYTKSIVHR*YGFIS*FLVLFFDLCACAYCST TLF*LL*LCSKF*NQQV*VRYLCSSFSILL*VSG VSCITT*ILRSS

Sequence APP.bAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAG AAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAA TGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAA GCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGC TGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCG GCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGAT CCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTG CAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGAT CAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAG CCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCA AAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACC TTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGC AGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTG CTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACA CAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGT ACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGT TTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATT CCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAG CTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTG CTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACAT AAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGA TTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAA ACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F9 (forward primer)
APP.R1 (reverse primer)
Single exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ REPPALPPPPPPPQSLWKRWFERCALNKPRRGRA EQ*SPAGTLM*LKGSVPHSFTADVAATGTTLTQ KSTAWPCVAAPFLQQQPVPLMPLTSISRHLGMR MNMPISRKPKRGLRPSTERECPRS*ENGKRQNVK QRTCLKLIRRQLSSISRRKWNLWNRKQPTRDSS WWRHTWPEWKPCSMTAAAWPWRTTSPLCRLFLL GLVTCSIC*RSMSAQNRRTDSTP*SISSMCAWWI PRKPLRSGPRL*HTSV*FMSA*ISLSPCSTTCL QWPRRFRMKLMSCFRKSKTIQMTSWPT*LVNQG SVTETMLSCHL*PKRKPPWSSFP*MESSAWTISS RGILLGLTLCQPTQKTKLSLLMPALLPTED*PL DQVLG*QISRRRRSLK*RWMQNSDMTQDMKFII KNWCSLQKMWVQTKVQSLDSWWAVLS*RQ*SSSP W*C*RRNSTHPFIMVWWRLTPLSPQRSATCPRC SRTATKIQPTSSLSRCRTRPPPQQPLKLDSKTI ASLPIGVHL*NNVGRNKPVL*FTHYRLLTAVL*H K*MPELELIHTSVMYSISLYILVSILHY*WVLC TVKNLAVSN*CMNRFSPDYLSHSPLASCILFLW FVTQLSPTLHML*ESMGDASCERGSSAASLA*VF LS*SLCILKLNIFKYFRCFREIFFP*LHFTVQI AASAIFVI*ELRGYTRLFLRACFMCTH*ALRLQ AFLFLSTYLWVFDKEKNPCSL*ALLRGGWGGVLC WSSITKNSPKQFSAG*LYRIIAYDMIAFYTVLH K*IK*NNPGQDFSLKDDYRH*IIEVILGGEKRQ IQFSLTSLKFHL*YKRR*KWKWQYKGMRKACLDK PFF*DVSSICIKWCFHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA* LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC* CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR ENHQHCHHHHHHHRVCGRGGSRGVL*TSRDGAV PSNDLPLVL*CD*REVCPILLRRMWRQPEQL*HR RVLHGRVWQRHSYNSSQYP*CR*QVSRDTWG*E *TCPFPESQREA*GQAPRENVPGHERMGRGRTS SKELA*S**EGSYPAFPGESGIFGTGSSQRETAA GGDTHGQSGSHAQ*PPPPGPGELHHRSAGCSSS ASSRVQYAKEVCPRRTEGQTAHPKAFRACAHGG SQESRSDPVPGYDTPPCDL*AHESVSLPALQRAC SGRGDSG*S**AASERAKLFR*RLGQHD**TKD QLRKRCSHAIFDRNENHRGAPSREWRVQPGRSP AVAFFWG*LCASQHRKRS*AC*CPPCCRPRTDHS TRFWVDKYQDGGDL*SEDGCRIPT*LRI*SSSS KIGVLCRRCGFKQRCNHWTHGGRCCHSDSDRHH LGDAEEETVHIHSSWCGGG*RRCHPRGAPPVQDA AERLRKSNLQVL*ADAELDPRHSSL*SWTAKPL LHYPSVSIYRIMWEETNPFYDLLIIAF*QLCCN TSRCLNLN*STHQ*CILSLFTFWSLYYIINGFCV L*RI*LYQTSA*IDSLLIIYHIAP*PVVYYSCG L*PN*VLLYICFKNRWGMLHVNVGVQLLLLPKY SFPDHYAF*S*TFLSISDALERFFFHDCILLYRL LLLLYL*YRN*EDTHVCFFVPVLCAHIRH*DFK LFFFCPRIFGSLIKKRIPVHCKHFYGAGGEGCS AGLQLPRILQNNFLQDDCTESLLMT*SLSTLYYI NKLNKITPGKTFL*RMTTDIK*SK*FWVGRRGR FNFL*PV*SFIYDTKEDENGSGNIRG*GRHAWT NPSFKMCLQFV*NGVFM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE RTTSIATTTTTTTESVEEVVREVCSEQAETGPC RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT EEYCMAVCGSAIPTTAASTPDAVDKYLETPGDEN EHAHFQKAKERLEAKHRERMSQVMREWEEAERQ AKNLPKADKKAVIQHFQEKVESLEQEAANERQQ LVETHMARVEAMLNDRRRLALENYITALQAVPPR PRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVD PKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRI SYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ PWHSFGADSVPANTENEVEPVDARPAADRGLTT RPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQ KLVFFAEDVGSNKGAIIGLMVGGVVIATVIVIT LVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKM QQNGYENPTYKFFEQMQN*TPATAASEVGQQNHC FTTHRCPFIE*CGKKQTRFMIYSLSPFDSCAVT QVDA*T*INPHISNVFYLSLHFGLYTTLLMGFV YCKEFSCIKLVHE*ILS*LFIT*PLSQLYIILVV CDPIKSYFTYALRIDGGCFM*TWEFSCFSCLSI PFLITMHFKVKHF*VFQML*RDFFSMTAFYCTD CCFCYICDIGIKRIHTFVSSCLFYVHTLGIETSS FSFFVHVSLGL**RKESLFIVSTFTGRVGRGAL LVFNYQEFSKTIFCRMIVQNHCL*HDRFLHCIT *IN*IK*PRARLFFEG*LQTLNNRSNFGWGEEAD SIFFNQSEVSFMIQKKMKMEVAI*GDEEGMPGQ TLLLRCVFNLYKMVFSCK*IHSWRST

Sequence APP.aAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAG AAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAAC AGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCC AAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGC ATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGA CCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCA GAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCA GAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACG AAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAG AAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTC TGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGT GCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATG GTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCA GATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAG AAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATG TATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGAT TCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATC GATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAG TATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACA CACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGA AAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCA GGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGA AGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAA AAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGT TTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F9 (forward primer)
APP.R1 (reverse primer)
Single exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ REPPALPPPPPPPQSLWKRWFERCALNKPRRGRA EQ*SPAGTLM*LKGSVPHSFTADVAATGTTLTQ KSTAWPCVAAPCPKVYSRLPRNLLPEILLNFLQ QQPVPLMPLTSISRHLGMRMNMPISRKPKRGLRP STERECPRS*ENGKRQNVKQRTCLKLIRRQLSS ISRRKWNLWNRKQPTRDSSWWRHTWPEWKPCSM TAAAWPWRTTSPLCRLFLLGLVTCSIC*RSMSAQ NRRTDSTP*SISSMCAWWIPRKPLRSGPRL*HT SV*FMSA*ISLSPCSTTCLQWPRRFRMKLMSCF RKSKTIQMTSWPT*LVNQGSVTETMLSCHL*PKR KPPWSSFP*MESSAWTISSRGILLGLTLCQPTQ KTKLSLLMPALLPTED*PLDQVLG*QISRRRRS LK*RWMQNSDMTQDMKFIIKNWCSLQKMWVQTKV QSLDSWWAVLS*RQ*SSSPW*C*RRNSTHPFIM VWWRLTPLSPQRSATCPRCSRTATKIQPTSSLS RCRTRPPPQQPLKLDSKTIASLPIGVHL*NNVGR NKPVL*FTHYRLLTAVL*HK*MPELELIHTSVM YSISLYILVSILHY*WVLCTVKNLAVSN*CMNR FSPDYLSHSPLASCILFLWFVTQLSPTLHML*ES MGDASCERGSSAASLA*VFLS*SLCILKLNIFK YFRCFREIFFP*LHFTVQIAASAIFVI*ELRGY TRLFLRACFMCTH*ALRLQAFLFLSTYLWVFDKE KNPCSL*ALLRGGWGGVLCWSSITKNSPKQFSA G*LYRIIAYDMIAFYTVLHK*IK*NNPGQDFSL KDDYRH*IIEVILGGEKRQIQFSLTSLKFHL*YK RR*KWKWQYKGMRKACLDKPFF*DVSSICIKWC FHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA* LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC* CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR ENHQHCHHHHHHHRVCGRGGSRGVL*TSRDGAV PSNDLPLVL*CD*REVCPILLRRMWRQPEQL*HR RVLHGRVWQRHVPKFTQDYPGTSCPRSC*TSYN SSQYP*CR*QVSRDTWG*E*TCPFPESQREA*G QAPRENVPGHERMGRGRTSSKELA*S**EGSYPA FPGESGIFGTGSSQRETAAGGDTHGQSGSHAQ* PPPPGPGELHHRSAGCSSSASSRVQYAKEVCPR RTEGQTAHPKAFRACAHGGSQESRSDPVPGYDTP PCDL*AHESVSLPALQRACSGRGDSG*S**AAS ERAKLFR*RLGQHD**TKDQLRKRCSHAIFDRN ENHRGAPSREWRVQPGRSPAVAFFWG*LCASQHR KRS*AC*CPPCCRPRTDHSTRFWVDKYQDGGDL *SEDGCRIPT*LRI*SSSSKIGVLCRRCGFKQR CNHWTHGGRCCHSDSDRHHLGDAEEETVHIHSSW CGGG*RRCHPRGAPPVQDAAERLRKSNLQVL*A DAELDPRHSSL*SWTAKPLLHYPSVSIYRIMWE ETNPFYDLLIIAF*QLCCNTSRCLNLN*STHQ*C ILSLFTFWSLYYIINGFCVL*RI*LYQTSA*ID SLLIIYHIAP*PVVYYSCGL*PN*VLLYICFKN RWGMLHVNVGVQLLLLPKYSFPDHYAF*S*TFLS ISDALERFFFHDCILLYRLLLLLYL*YRN*EDT HVCFFVPVLCAHIRH*DFKLFFFCPRIFGSLIK KRIPVHCKHFYGAGGEGCSAGLQLPRILQNNFLQ DDCTESLLMT*SLSTLYYINKLNKITPGKTFL* RMTTDIK*SK*FWVGRRGRFNFL*PV*SFIYDT KEDENGSGNIRG*GRHAWTNPSFKMCLQFV*NGV FM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE RTTSIATTTTTTTESVEEVVREVCSEQAETGPC RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT EEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTT AASTPDAVDKYLETPGDENEHAHFQKAKERLEA KHRERMSQVMREWEEAERQAKNLPKADKKAVIQ HFQEKVESLEQEAANERQQLVETHMARVEAMLND RRRLALENYITALQAVPPRPRHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTH LRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQ KEQNYSDDVLANMISEPRISYGNDALMPSLTET KTTVELLPVNGEFSLDDLQPWHSFGADSVPANT ENEVEPVDARPAADRGLTTRPGSGLTNIKTEEIS EVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKG AIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH GVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ MQN*TPATAASEVGQQNHCFTTHRCPFIE*CGK KQTRFMIYSLSPFDSCAVTQVDA*T*INPHISN VFYLSLHFGLYTTLLMGFVYCKEFSCIKLVHE*I LS*LFIT*PLSQLYIILVVCDPIKSYFTYALRI DGGCFM*TWEFSCFSCLSIPFLITMHFKVKHF* VFQML*RDFFSMTAFYCTDCCFCYICDIGIKRIH TFVSSCLFYVHTLGIETSSFSFFVHVSLGL**R KESLFIVSTFTGRVGRGALLVFNYQEFSKTIFC RMIVQNHCL*HDRFLHCIT*IN*IK*PRARLFFE G*LQTLNNRSNFGWGEEADSIFFNQSEVSFMIQ KKMKMEVAI*GDEEGMPGQTLLLRCVFNLYKMV FSCK*IHSWRST