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Sequences

Sequence APP.eAug05

GGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCT GAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAA CCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGC CCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTC CAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTA AAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACAT GGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTC AATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTC AGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGAT TCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGAT GCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTG GGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCG ACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGT GTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCA CCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGC AGCCTCTGAAGTTGGACAGCAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATT AATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCA AACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTT TACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTT AAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATA TAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATC TTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTC TCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCC GGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGA AGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTC AATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F9 (forward primer)
APP.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

GG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRSG *GGRRRSR**RGR*GW**GRGRG*GTLRRSHREN HQHCHHHHHHHRVCGRGGSSVPKFTQDYPGTSC PRSC*TSYNSSQYP*CR*QVSRDTWG*E*TCPF PESQREA*GQAPRENVPGHERMGRGRTSSKELA* S**EGSYPAFPGESGIFGTGSSQRETAAGGDTH GQSGSHAQ*PPPPGPGELHHRSAGCSSSASSRV QYAKEVCPRRTEGQTAHPKAFRACAHGGSQESRS DPVPGYDTPPCDL*AHESVSLPALQRACSGRGD SG*S**AASERAKLFR*RLGQHD**TKDQLRKR CSHAIFDRNENHRGAPSREWRVQPGRSPAVAFFW G*LCASQHRKRRFWVDKYQDGGDL*SEDGCRIP T*LRI*SSSSKIGVLCRRCGFKQRCNHWTHGGR CCHSDSDRHHLGDAEEETVHIHSSWCGGG*RRCH PRGAPPVQDAAERLRKSNLQVL*ADAELDPRHS SL*SWTATNPFYDLLIIAF*QLCCNTSRCLNLN *STHQ*CILSLFTFWSLYYIINGFCVL*RI*LYQ TSA*IDSLLIIYHIAP*PVVYYSCGL*PN*VLL YICFKNRWGMLHVNVGVQLLLLPKYSFPDHYAF *S*TFLSISDALERFFFHDCILLYRLLLLLYL*Y RN*EDTHVCFFVPVLCAHIRH*DFKLFFFCPRI FGSLIKKRIPVHCKHFYGAGGEGCSAGLQLPRI LQNNFLQDDCTESLLMT*SLSTLYYINKLNKITP GKTFL*RMTTDIK*SK*FWVGRRGRFNFL*PV* SFIYDTKEDENGSGNIRG*GRHAWTNPSFKMCL QFV*NGVFM*INTFLEEHH

Frame 1

EDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA EVEEEEADDDEDDEDGDEVEEEAEEPYEEATER TTSIATTTTTTTESVEEVVRVSQSLLKTTQEPLA RDPVKLPTTAASTPDAVDKYLETPGDENEHAHF QKAKERLEAKHRERMSQVMREWEEAERQAKNLP KADKKAVIQHFQEKVESLEQEAANERQQLVETHM ARVEAMLNDRRRLALENYITALQAVPPRPRHVF NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEI QDEVDELLQKEQNYSDDVLANMISEPRISYGND ALMPSLTETKTTVELLPVNGEFSLDDLQPWHSF GADSVPANTENEGSGLTNIKTEEISEVKMDAEFR HDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGG VVIATVIVITLVMLKKKQYTSIHHGVVEVDAAV TPEERHLSKMQQNGYENPTYKFFEQMQN*TPATA ASEVGQQQTRFMIYSLSPFDSCAVTQVDA*T*I NPHISNVFYLSLHFGLYTTLLMGFVYCKEFSCI KLVHE*ILS*LFIT*PLSQLYIILVVCDPIKSYF TYALRIDGGCFM*TWEFSCFSCLSIPFLITMHF KVKHF*VFQML*RDFFSMTAFYCTDCCFCYICD IGIKRIHTFVSSCLFYVHTLGIETSSFSFFVHVS LGL**RKESLFIVSTFTGRVGRGALLVFNYQEF SKTIFCRMIVQNHCL*HDRFLHCIT*IN*IK*P RARLFFEG*LQTLNNRSNFGWGEEADSIFFNQSE VSFMIQKKMKMEVAI*GDEEGMPGQTLLLRCVF NLYKMVFSCK*IHSWRST

Frame 2

RMTRMSGGAEQTQTMQMGVKTK**K*QRRKKWL RWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQRE PPALPPPPPPPQSLWKRWFECPKVYSRLPRNLL PEILLNFLQQQPVPLMPLTSISRHLGMRMNMPIS RKPKRGLRPSTERECPRS*ENGKRQNVKQRTCL KLIRRQLSSISRRKWNLWNRKQPTRDSSWWRHT WPEWKPCSMTAAAWPWRTTSPLCRLFLLGLVTCS IC*RSMSAQNRRTDSTP*SISSMCAWWIPRKPL RSGPRL*HTSV*FMSA*ISLSPCSTTCLQWPRR FRMKLMSCFRKSKTIQMTSWPT*LVNQGSVTETM LSCHL*PKRKPPWSSFP*MESSAWTISSRGILL GLTLCQPTQKTKVLG*QISRRRRSLK*RWMQNS DMTQDMKFIIKNWCSLQKMWVQTKVQSLDSWWAV LS*RQ*SSSPW*C*RRNSTHPFIMVWWRLTPLS PQRSATCPRCSRTATKIQPTSSLSRCRTRPPPQ QPLKLDSNKPVL*FTHYRLLTAVL*HK*MPELEL IHTSVMYSISLYILVSILHY*WVLCTVKNLAVS N*CMNRFSPDYLSHSPLASCILFLWFVTQLSPT LHML*ESMGDASCERGSSAASLA*VFLS*SLCIL KLNIFKYFRCFREIFFP*LHFTVQIAASAIFVI *ELRGYTRLFLRACFMCTH*ALRLQAFLFLSTY LWVFDKEKNPCSL*ALLRGGWGGVLCWSSITKNS PKQFSAG*LYRIIAYDMIAFYTVLHK*IK*NNP GQDFSLKDDYRH*IIEVILGGEKRQIQFSLTSL KFHL*YKRR*KWKWQYKGMRKACLDKPFF*DVSS ICIKWCFHVNKYILGGAP

Sequence APP.fAug05

CTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAAC TCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTC CGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAG CAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGA GGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACC ACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTG AAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCC TACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTT GAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTA TCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTC CGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGA CACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGGTGCAGT GGCTCATGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGTGGGCAGATGACTTGAGCCCAGAAGTTCAAGACCAGAATGGGAAACATGGCAAGACCACAT TTCTACAAAAAAATTATCCAGGCATGATAACATCTATTTGTAGTCCCAGCTACTCAGGAGGCTGTGGTGGGAGGATCTCCTGAGCCTGGGGTGGCTGAGG CTGCAGTGAGCCTTGATCACGCCACCTGGGCAATAGAGCAAGACCCTGTCTCAAAAAAAGGAAGAAAAAGACTATTATTTCCCCCATTGAATGGTCTTGG CACTATTACACAAAATCAATTGTCCATAGATAATATGGGTTTATTTCTTAATTCTTAGTTCTTTTCTTTGATCTGTGTGCCTGTGCTTACTGTAGTACCA CACTGTTTTGATTATTGTAGCTTTGTAGTAAATTTTGAAATCAGCAAGTGTGAGTCCGTTATCTTTGTTCTTCTTTTTCAATATTACTTTGAGTATCCGG AGTCTCTTGCATTACAACATGAATTTTAAGATCTTCC

APP.F9 (forward primer)
APP.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

LQITNVVEANQPVTIQNWCKRGRKQCKTHPHFV IPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGG ADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDE DDEDGDEVEEEAEEPYEEATERTTSIATTTTTT TESVEEVVREVCSEQAETGPCRAMISRWYFDVT EGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIP TTAASTPDAVDKYLETPGDENEHAHFQKAKERL EAKHRERMSQVMREWEEAERQAKNLPKADKKAV IQHFQEKVESLEQEAANERQQLVETHMARVEAML NDRRRLALENYITALQAVPPRPRHVFNMLKKYV RAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM THLRVIYERMNQSLSLLYNVPAVAEEIQDEVGAV AHACNSSILGGQGGQMT*AQKFKTRMGNMARPH FYKKIIQA**HLFVVPATQEAVVGGSPEPGVAE AAVSLDHATWAIEQDPVSKKGRKRLLFPPLNGLG TITQNQLSIDNMGLFLNS*FFSLICVPVLTVVP HCFDYCSFVVNFEISKCESVIFVLLFQYYFEYP ESLALQHEF*DL

Frame 1

CRSPMW*KPTNQ*PSRTGASGAASSARPIPTL* FPTAA*LVSL*VMPFSFLTSANSYTRRGWMFAK LIFTGTPSPKRHAVRRVPTCMTTACCCPAELTSS EG*SLCVAHWLKKVTMWILLMRRRMTRMSGGAE QTQTMQMGVKTK**K*QRRKKWLRWKKKKPMMT RTMRMVMR*RKRLRNPTKKPQREPPALPPPPPPP QSLWKRWFERCALNKPRRGRAEQ*SPAGTLM*L KGSVPHSFTADVAATGTTLTQKSTAWPCVAAPF LQQQPVPLMPLTSISRHLGMRMNMPISRKPKRGL RPSTERECPRS*ENGKRQNVKQRTCLKLIRRQL SSISRRKWNLWNRKQPTRDSSWWRHTWPEWKPC SMTAAAWPWRTTSPLCRLFLLGLVTCSIC*RSMS AQNRRTDSTP*SISSMCAWWIPRKPLRSGPRL* HTSV*FMSA*ISLSPCSTTCLQWPRRFRMKLVQ WLMPVIPAFWEAKVGR*LEPRSSRPEWETWQDHI STKKLSRHDNIYL*SQLLRRLWWEDLLSLGWLR LQ*ALITPPGQ*SKTLSQKKEEKDYYFPH*MVL ALLHKINCP*IIWVYFLILSSFL*SVCLCLL*YH TVLIIVAL**ILKSASVSPLSLFFFFNITLSIR SLLHYNMNFKIF

Frame 2

ADHQCGRSQPTSDHPELVQAGPQAVQDPSPLCD SLPLLSW*VCK*CPSRS*QVQILTPGEDGCLRN SSSLAHRRQRDMQ*EEYQLA*LRHVAALRN*QV PRGRVCVLPTG*RK*QCGFC*CGGG*LGCLVGRS RHRLCRWE*RQSSRSSRGGRSG*GGRRRSR**R GR*GW**GRGRG*GTLRRSHRENHQHCHHHHHH HRVCGRGGSRGVL*TSRDGAVPSNDLPLVL*CD* REVCPILLRRMWRQPEQL*HRRVLHGRVWQRHS YNSSQYP*CR*QVSRDTWG*E*TCPFPESQREA *GQAPRENVPGHERMGRGRTSSKELA*S**EGSY PAFPGESGIFGTGSSQRETAAGGDTHGQSGSHA Q*PPPPGPGELHHRSAGCSSSASSRVQYAKEVC PRRTEGQTAHPKAFRACAHGGSQESRSDPVPGYD TPPCDL*AHESVSLPALQRACSGRGDSG*SWCS GSCL*FQHFGRPRWADDLSPEVQDQNGKHGKTT FLQKNYPGMITSICSPSYSGGCGGRIS*AWGG*G CSEP*SRHLGNRARPCLKKRKKKTIISPIEWSW HYYTKSIVHR*YGFIS*FLVLFFDLCACAYCST TLF*LL*LCSKF*NQQV*VRYLCSSFSILL*VSG VSCITT*ILRSS

Sequence APP.bAug05

GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCG GGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGA TTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGA AGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCA AATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGA CTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGA GAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAG AAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAA TGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAA GCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGC TGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCG GCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGAT CCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTG CAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGAT CAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAG CCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCA AAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACC TTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGC AGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTG CTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACA CAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGT ACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGT TTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATT CCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAG CTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTG CTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACAT AAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGA TTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAA ACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCACCAT

APP.F9 (forward primer)
APP.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

GSADSPGSEPRRRARAPSVSSAAVGESTRRSVR GGPGRRRRWRRGQSKDAADPTRTAAHSVPRAGSR CCPVWHCSCWPPGRLGRWRYPLMVMLACWLNPR LPCSVAD*TCT*MSRMGSGIQIHQGPKPALIPR KASCSIAKKSTLNCRSPMW*KPTNQ*PSRTGASG AASSARPIPTL*FPTAA*LVSL*VMPFSFLTSA NSYTRRGWMFAKLIFTGTPSPKRHAVRRVPTCM TTACCCPAELTSSEG*SLCVAHWLKKVTMWILLM RRRMTRMSGGAEQTQTMQMGVKTK**K*QRRKK WLRWKKKKPMMTRTMRMVMR*RKRLRNPTKKPQ REPPALPPPPPPPQSLWKRWFERCALNKPRRGRA EQ*SPAGTLM*LKGSVPHSFTADVAATGTTLTQ KSTAWPCVAAPFLQQQPVPLMPLTSISRHLGMR MNMPISRKPKRGLRPSTERECPRS*ENGKRQNVK QRTCLKLIRRQLSSISRRKWNLWNRKQPTRDSS WWRHTWPEWKPCSMTAAAWPWRTTSPLCRLFLL GLVTCSIC*RSMSAQNRRTDSTP*SISSMCAWWI PRKPLRSGPRL*HTSV*FMSA*ISLSPCSTTCL QWPRRFRMKLMSCFRKSKTIQMTSWPT*LVNQG SVTETMLSCHL*PKRKPPWSSFP*MESSAWTISS RGILLGLTLCQPTQKTKLSLLMPALLPTED*PL DQVLG*QISRRRRSLK*RWMQNSDMTQDMKFII KNWCSLQKMWVQTKVQSLDSWWAVLS*RQ*SSSP W*C*RRNSTHPFIMVWWRLTPLSPQRSATCPRC SRTATKIQPTSSLSRCRTRPPPQQPLKLDSKTI ASLPIGVHL*NNVGRNKPVL*FTHYRLLTAVL*H K*MPELELIHTSVMYSISLYILVSILHY*WVLC TVKNLAVSN*CMNRFSPDYLSHSPLASCILFLW FVTQLSPTLHML*ESMGDASCERGSSAASLA*VF LS*SLCILKLNIFKYFRCFREIFFP*LHFTVQI AASAIFVI*ELRGYTRLFLRACFMCTH*ALRLQ AFLFLSTYLWVFDKEKNPCSL*ALLRGGWGGVLC WSSITKNSPKQFSAG*LYRIIAYDMIAFYTVLH K*IK*NNPGQDFSLKDDYRH*IIEVILGGEKRQ IQFSLTSLKFHL*YKRR*KWKWQYKGMRKACLDK PFF*DVSSICIKWCFHVNKYILGGAP

Frame 1

DQLTRLALSPAAALGLRQFPRQR*ARARGGACA GAPGDGGGGGAGRARTRRIPLAQQRTRCPAQGR DAARFGTAPAGRLDGSGAGGTH*W*CWPAG*TPD CHVLWQTEHAHECPEWEVGFRSIRDQNLH*YQG RHPAVLPRSLP*TADHQCGRSQPTSDHPELVQA GPQAVQDPSPLCDSLPLLSW*VCK*CPSRS*QVQ ILTPGEDGCLRNSSSLAHRRQRDMQ*EEYQLA* LRHVAALRN*QVPRGRVCVLPTG*RK*QCGFC* CGGG*LGCLVGRSRHRLCRWE*RQSSRSSRGGRS G*GGRRRSR**RGR*GW**GRGRG*GTLRRSHR ENHQHCHHHHHHHRVCGRGGSRGVL*TSRDGAV PSNDLPLVL*CD*REVCPILLRRMWRQPEQL*HR RVLHGRVWQRHSYNSSQYP*CR*QVSRDTWG*E *TCPFPESQREA*GQAPRENVPGHERMGRGRTS SKELA*S**EGSYPAFPGESGIFGTGSSQRETAA GGDTHGQSGSHAQ*PPPPGPGELHHRSAGCSSS ASSRVQYAKEVCPRRTEGQTAHPKAFRACAHGG SQESRSDPVPGYDTPPCDL*AHESVSLPALQRAC SGRGDSG*S**AASERAKLFR*RLGQHD**TKD QLRKRCSHAIFDRNENHRGAPSREWRVQPGRSP AVAFFWG*LCASQHRKRS*AC*CPPCCRPRTDHS TRFWVDKYQDGGDL*SEDGCRIPT*LRI*SSSS KIGVLCRRCGFKQRCNHWTHGGRCCHSDSDRHH LGDAEEETVHIHSSWCGGG*RRCHPRGAPPVQDA AERLRKSNLQVL*ADAELDPRHSSL*SWTAKPL LHYPSVSIYRIMWEETNPFYDLLIIAF*QLCCN TSRCLNLN*STHQ*CILSLFTFWSLYYIINGFCV L*RI*LYQTSA*IDSLLIIYHIAP*PVVYYSCG L*PN*VLLYICFKNRWGMLHVNVGVQLLLLPKY SFPDHYAF*S*TFLSISDALERFFFHDCILLYRL LLLLYL*YRN*EDTHVCFFVPVLCAHIRH*DFK LFFFCPRIFGSLIKKRIPVHCKHFYGAGGEGCS AGLQLPRILQNNFLQDDCTESLLMT*SLSTLYYI NKLNKITPGKTFL*RMTTDIK*SK*FWVGRRGR FNFL*PV*SFIYDTKEDENGSGNIRG*GRHAWT NPSFKMCLQFV*NGVFM*INTFLEEHH

Frame 2

IS*LAWL*APPPRSGSVSFLGSGRREHAEERAR GPRETAAVAARAEQGRGGSHSHSSALGAPRRVA MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQ IAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKC KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHD YGMLLPCGIDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEE VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATE RTTSIATTTTTTTESVEEVVREVCSEQAETGPC RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT EEYCMAVCGSAIPTTAASTPDAVDKYLETPGDEN EHAHFQKAKERLEAKHRERMSQVMREWEEAERQ AKNLPKADKKAVIQHFQEKVESLEQEAANERQQ LVETHMARVEAMLNDRRRLALENYITALQAVPPR PRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVD PKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRI SYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ PWHSFGADSVPANTENEVEPVDARPAADRGLTT RPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQ KLVFFAEDVGSNKGAIIGLMVGGVVIATVIVIT LVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKM QQNGYENPTYKFFEQMQN*TPATAASEVGQQNHC FTTHRCPFIE*CGKKQTRFMIYSLSPFDSCAVT QVDA*T*INPHISNVFYLSLHFGLYTTLLMGFV YCKEFSCIKLVHE*ILS*LFIT*PLSQLYIILVV CDPIKSYFTYALRIDGGCFM*TWEFSCFSCLSI PFLITMHFKVKHF*VFQML*RDFFSMTAFYCTD CCFCYICDIGIKRIHTFVSSCLFYVHTLGIETSS FSFFVHVSLGL**RKESLFIVSTFTGRVGRGAL LVFNYQEFSKTIFCRMIVQNHCL*HDRFLHCIT *IN*IK*PRARLFFEG*LQTLNNRSNFGWGEEAD SIFFNQSEVSFMIQKKMKMEVAI*GDEEGMPGQ TLLLRCVFNLYKMVFSCK*IHSWRST