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Sequences

Sequence DNMT3B.fAug05

ACCCACTCCCGCTGCCCCGTCCGGCCCGCGCCGCTTCCTCGCAGCAGCTGCTCCCGGCTCCGCGGCCGCAGCCCGCGTGGACGCTCCGAGCGCCCCCCGA
CGGACGGGACCGGCTCCCTGGCGGTCGGGCGAGCGGGCGGCAACGCTGCCCGGCCGGCAGCGCTGGGGTTAAGTGGCCCAAGTAAACCTAGCTCGGCGAT
CGGCGCCGGAGATTCGCGAGCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAG
CCAGCCCTGCGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCT
GCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGT
GTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAA
ACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAGGCCTTCCCCACGTTCCACCCGAGGCC
GGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTC
CCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAG
GACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGG
ACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTG
GGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTCTCTGCAGACAAACTGGTGGCACTGGGGCTGTTCAGCCAGCACTTTAATTTGGCCACCTTCAAT
AAGCTCGTCTCCTATCGAAAAGCCATGTACCATGCTCTGGAGAAAGCTAGGGTGCGAGCTGGCAAGACCTTCCCCAGCAGCCCTGGAGACTCATTGGAGG
ACCAGCTGAAGCCCATGTTGGAGTGGGCCCACGGGGGCTTCAAGCCCACTGGGATCGAGGGCCTCAAACCCAACAACACGCAACCAGAGAACAAGACTCG
AAGACGCACAGCTGACGACTCAGCCACCTCTGACTACTGCCCCGCACCCAAGCGCCTCAAGACAAATTGCTATAACAACGGCAAAGACCGAGGGGATGAA
GATCAGAGCCGAGAACAAATGGCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGATGGCTGTTTGTCTTGTGGCAGGAAAAACCCCGTGTCCTTCC
ACCCTCTCTTTGAGGGGGGGCTCTGTCAGACATGCCGGCACCTGTGTGGAGACTCAGTGAAGCCCACTCATCCCAGCTGCCTTGCACTCTGCCTCTGGGG
CAGGATGGGGGACAGCTGTCACAGAGGCCAATGGCACGCAGGTCACAGCCAGTTGTCCTTTTAAAGGACACCAAGCCACCAGCAGTGTGTTCTGCAGCTG
TATCCTAGGGCCTCCACCAGCAAGCCGGCAGGGCCTGCCCTTCTCTGGTCTCCGATTTCACTGGTGTTTCTCTCTGGCTGCCAGGATCGCTTCCTTGAGC
TGTTTTACATGTATGATGACGATGGCTATCAGTCTTACTGCACTGTGTGCTGCGAGGGCCGAGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTG
TTTCTGTGTGGAGTGCCTGGAGGTGCTGGTGGGCACAGGCACAGCGGCCGAGGCCAAGCTTCAGGAGCCCTGGAGCTGTTACATGTGTCTCCCGCAGCGC
TGTCATGGCGTCCTGCGGCGCCGGAAGGACTGGAACGTGCGCCTGCAGGCCTTCTTCACCAGTGACACGGGGCTTGAATATGAAGCCCCCAAGCTGTACC
CTGCCATTCCCGCAGCCCGAAGGCGGCCCATTCGAGTCCTGTCATTGTTTGATGGCATCGCGACAGGCTACCTAGTCCTCAAAGAGTTGGGCATAAAGGT
AGGAAAGTACGTCGCTTCTGAAGTGTGTGAGGAGTCCATTGCTGTTGGAACCGTGAAGCACGAGGGGAATATCAAATACGTGAACGACGTGAGGAACATC
ACAAAGAAAAATATTGAAGAATGGGGCCCATTTGACTTGGTGATTGGCGGAAGCCCATGCAACGATCTCTCAAATGTGAATCCAGCCAGGAAAGGCCTGT
ATGAGGGTACAGGCCGGCTCTTCTTCGAATTTTACCACCTGCTGAATTACTCACGCCCCAAGGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAA
TGTTGTAGCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGTGTAATCCAGTGATGATTGATGCCATCAAAGTTTCTGCTGCTCACAGG
GCCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAGA
AGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCC
CACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCT
CAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAG
CAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTC
AGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTT
AATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCA
GGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATT
TTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAA
TCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAAGTATGGC
TCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCC
ACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTC
TCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTT
TTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAAT
AAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGT
AACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTT
ACCTTATGTTTAATTAAAATCAGTATTTGTCTATAA
  • DNMT3B.u.f.26 (forward primer)
  • DNMT3B.u.r.28 (reverse primer)
  • Single exon skipping

Frame 0

THSRCPVRPAPLPRSSCSRLRGRSPRGRSERPP
TDGTGSLAVGRAGGNAARPAALGLSGPSKPSSAI
GAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQ
PALRQESMKGDTRHLNGEEDAGGREDSILVNGA
CSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRE
TRTRSESPAVRTRNNNSVSSRERHRPSPRSTRG
RQGRNHVDESPVEFPATRSLRRRATASAGTPWPS
PPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQ
DSQQGGMESPQVEADSGDGDSSEYQDGKEFGIG
DLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRW
VQWFGDGKFSEVSADKLVALGLFSQHFNLATFN
KLVSYRKAMYHALEKARVRAGKTFPSSPGDSLE
DQLKPMLEWAHGGFKPTGIEGLKPNNTQPENKTR
RRTADDSATSDYCPAPKRLKTNCYNNGKDRGDE
DQSREQMASDVANNKSSLEDGCLSCGRKNPVSF
HPLFEGGLCQTCRHLCGDSVKPTHPSCLALCLWG
RMGDSCHRGQWHAGHSQLSF*RTPSHQQCVLQL
YPRASTSKPAGPALLWSPISLVFLSGCQDRFLE
LFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRC
FCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQR
CHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLY
PAIPAARRRPIRVLSLFDGIATGYLVLKELGIKV
GKYVASEVCEESIAVGTVKHEGNIKYVNDVRNI
TKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGL
YEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFEN
VVAMKVGDKRDISRFLECNPVMIDAIKVSAAHR
ARYFWGNLPGMNRIFGFPVHYTDVSNMGRGARQ
KLLGRSWSVPVIRHLFAPLKDYFACE*FQPGPKP
TGVCGRARTQEV*FLKASPGPALPQLCGSYRVP
QFPLAQWGQSHLTLAGVA*GAASLCTNQTWLLG
AA*HGAHFFFS*NFKT*SR*QRGFFFFPSWVYHS
EKQWLRYQNHSADSSPILRLMLKNHPRQLLQEF
NF*KLATALCLQTCAVVGM*LQDIFKGPGSFFP
RASRRENVVYVFYPAHSPCLNTRAGVCTGPIRVF
STMMMISAGMTSSSHSGLFFPPQTQGQGPLLAK
SLPVTAIEPSGELRKGCAEFYNISCHIFCRQVW
LLHISLFPRRGV*SKELR*DTPSNPFPLQETYPP
QAQVPR*EVCYPHFSSFY*TQRQ*QQSGTDIHF
SYLPHI*EMTGKTAKLGAPFGDFLILFYSIRSR
F*GEREFRQAAFQKCCHNGF*HLLLFLLVLFCRI
RNNVDKFCGAFYTLFKISNFYFYV*RFH*NFFC
NWSHDVTNMGKKLCLVSTVFANF*AER*RMPRV
YLMFN*NQYLSI

Frame 1

PTPAAPSGPRRFLAAAAPGSAAAARVDAPSAPR
RTGPAPWRSGERAATLPGRQRWG*VAQVNLARR
SAPEIREPSALHGRQPASRQPAPTRGSAAQPRPS
QPCGRKA*RETPGISMERRTPAGGKTRSSSTGP
AATSPPTRPQSWRLSAPRRSEAEDQARDSPRGR
CPVC*ATHRT*QAMATGKMGMALTPQSCQSSSGK
PGLVQKAQLSELEITTVSPAGRGTGLPHVPPEA
GRAATMWTSPPWSSRLPGP*DGGQQHRQERHGR
PLPALTLPSTSQTTQRTHMGRPRAAVPPTPA*PR
TASRGAWSPRRWRQTVEMETVQSIRMGRSLE*G
TSCGERSRASPGGPPWWCLGRPPPSDRLCLACG
GSSGLAMASSPRSLQTNWWHWGCSASTLIWPPSI
SSSPIEKPCTMLWRKLGCELARPSPAALETHWR
TS*SPCWSGPTGASSPLGSRASNPTTRNQRTRL
EDAQLTTQPPLTTAPHPSASRQIAITTAKTEGMK
IRAENKWLQMLPTTRAAWKMAVCLVAGKTPCPS
TLSLRGGSVRHAGTCVETQ*SPLIPAALHSASG
AGWGTAVTEANGTQVTASCPFKGHQATSSVFCSC
ILGPPPASRQGLPFSGLRFHWCFSLAARIASLS
CFTCMMTMAISLTALCAARAESCCFAATRAAAG
VSVWSAWRCWWAQAQRPRPSFRSPGAVTCVSRSA
VMASCGAGRTGTCACRPSSPVTRGLNMKPPSCT
LPFPQPEGGPFESCHCLMASRQAT*SSKSWA*R
*ESTSLLKCVRSPLLLEP*STRGISNT*TT*GTS
QRKILKNGAHLTW*LAEAHATISQM*IQPGKAC
MRVQAGSSSNFTTC*ITHAPRRVMTGRSSGCLR
ML*P*RLATRGTSHGSWSVIQ**LMPSKFLLLTG
PDTSGATYPG*TGSLAFLCTTQTCPTWAVVPAR
SCWEGPGACLSSDTSSPL*RTTLHVNSSSQAPS
PLGCVAEPGPRRCDS*RHPQALLFLSCVGHTVYL
SSLLLSGGRAT*LLQG*PEVPPPCAQIRPGCLE
QPNTVLIFSSPKTLKLEVGSNVAFFFSLPGSTT
QRNNG*DTKTTVPTALQYSG*C*KIIQDSYCKSL
IFENWLLLCVYRRVQL*ACSYRTFLRAQDRFFP
GQAEEKMLYMSFTRHIPLA*IQGLESARDLLEY
FPQ***FQQG*RHHHIQGYFFPHKPKGRGHS*LN
PSP*LQ*NPLGSSGRGVLSSII*AAIYFVDKYG
SSISPSSLGEECEARSLDKTPPQTHSLSRRPTL
HRHRSPDEKSATLISHLFTKLRGSDSSQGQTYIS
HTFPTSER*QGKLQSSVLPLEIF*SFFIP*EVV
FRENGNSDKLHFRNAVIMVFNTFYSSYWCYFVE
*GTTLTSFVGLFIHFLKSQTSIFMFNVFIKIFFV
TGATT*QIWGKNCALFQQFLLIFRLKDDGCLEF
TLCLIKISICL*

Frame 2

PLPLPRPARAASSQQLLPAPRPQPAWTLRAPPD
GRDRLPGGRASGRQRCPAGSAGVKWPK*T*LGD
RRRRFASPAPCTAASRPPASQPRPAAPPPSRAP
ASPAAGKHEGRHQASQWRGGRRREGRLDPRQRGL
QRPVLRLAPNPGGYPHPGDQRPKIKLATLQEGG
VQSAKLHTGLDRRWRRGRWGWL*HPSHAKALPG
NQDSFRKPSCPNSK*QQCLQPGEAQAFPTFHPRP
AGPQPCGRVPRGVPGYQVPETAGNSIGRNAMAV
PSQLLPYHRPHRRHRGHTWDAPEQQYPLRPPSP
GQPAGGHGVPAGGGRQWRWRQFRVSGWEGVWNRG
PRVGKDQGLLLVARHGGVLEGHLQATGYVWHAV
GPVVWRWQVLRGLCRQTGGTGAVQPAL*FGHLQ
*ARLLSKSHVPCSGES*GASWQDLPQQPWRLIGG
PAEAHVGVGPRGLQAHWDRGPQTQQHATREQDS
KTHS*RLSHL*LLPRTQAPQDKLL*QRQRPRG*
RSEPRTNGFRCCQQQEQPGRWLFVLWQEKPRVLP
PSL*GGALSDMPAPVWRLSEAHSSQLPCTLPLG
QDGGQLSQRPMARRSQPVVLLKDTKPPAVCSAA
VS*GLHQQAGRACPSLVSDFTGVSLWLPGSLP*A
VLHV**RWLSVLLHCVLRGPRAAALQQHELLPV
FLCGVPGGAGGHRHSGRGQASGALELLHVSPAA
LSWRPAAPEGLERAPAGLLHQ*HGA*I*SPQAVP
CHSRSPKAAHSSPVIV*WHRDRLPSPQRVGHKG
RKVRRF*SV*GVHCCWNREARGEYQIRERREEH
HKEKY*RMGPI*LGDWRKPMQRSLKCESSQERPV
*GYRPALLRILPPAELLTPQGG**PAVLLDV*E
CCSHEGWRQEGHLTVPGV*SSDD*CHQSFCCSQ
GPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPE
AAGKVLERACHPTPLRPSEGLLCM*IVPARPQA
HWGVWQSQDPGGVIPEGIPRPCSSSAVWVIPCT
SVPSCSVGAEPPDSCRGSLRCRLLVHKSDLAAWS
SLTRCSFFLLLKL*NLK*VATWLFFFPFLGLPL
RETMAKIPKPQCRQLSNTQVNAEKSSKTVIARV
*FLKTGYCSVFTDVCSCRHVATGHF*GPRIVFSQ
GKQKRKCCICLLPGTFPLPKYKGWSLHGTY*SI
FHNDDDFSRDDVIITFRAIFSPTNPRAGATLS*
IPPRDCNRTLWGAQEGVC*VL*YKLPYIL*TSMA
PPYLPLP*ERSVKQGA*IRHPLKPIPSPGDLPS
TGTGPQMRSLLPSFLIFLLNSEAVTAVRDRHTF
LIPSPHLRDDRENCKARCSLWRFFNPFLFHKKSF
LGRTGIQTSCISEMLS*WFLTPFTLLTGAIL*N
KEQR*QVLWGFLYTF*NLKLLFLCLTFSLKFFL
*LEPRRNKYGEKTVPCFNSFC*FLG*KMTDA*SL
PYV*LKSVFVY

Sequence DNMT3B.eAug05

GATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGC
GACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTCTCTGCAGACAAACTGGTGGCACTGGGGCTGTTCAGCCA
GCACTTTAATTTGGCCACCTTCAATAAGCTCGTCTCCTATCGAAAAGCCATGTACCATGCTCTGGAGAAAGCTAGGGTGCGAGCTGGCAAGACCTTCCCC
AGCAGCCCTGGAGACTCATTGGAGGACCAGCTGAAGCCCATGTTGGAGTGGGCCCACGGGGGCTTCAAGCCCACTGGGATCGAGGGCCTCAAACCCAACA
ACACGCAACCAGTGGTTAATAAGTCGAAGGTGCGTCGTGCAGGCAGTAGGAAATTAGAATCAAGGAAATACGAGAACAAGACTCGAAGACGCACAGCTGA
CGACTCAGCCACCTCTGACTACTGCCCCGCACCCAAGCGCCTCAAGACAAATTGCTATAACAACGGCAAAGACCGAGGGGATGAAGATCAGAGCCGAGAA
CAAATGGCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGATGGCTGTTTGTCTTGTGGCAGGAAAAACCCCGTGTCCTTCCACCCTCTCTTTGAGG
GGGGGCTCTGTCAGACATGCCGGGATCGCTTCCTTGAGCTGTTTTACATGTATGATGACGATGGCTATCAGTCTTACTGCACTGTGTGCTGCGAGGGCCG
AGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTGTTTCTGTGTGGAGTGCCTGGAGGTGCTGGTGGGCACAGGCACAGCGGCCGAGGCCAAGCTT
CAGGAGCCCTGGAGCTGTTACATGTGTCTCCCGCAGCGCTGTCATGGCGTCCTGCGGCGCCGGAAGGACTGGAACGTGCGCCTGCAGGCCTTCTTCACCA
GTGACACGGGGCTTGAATATGAAGCCCCCAAGCTGTACCCTGCCATTCCCGCAGCCCGAAGGCGGCCCATTCGAGTCCTGTCATTGTTTGATGGCATCGC
GACAGGCTACCTAGTCCTCAAAGAGTTGGGCATAAAGGTAGGAAAGTACGTCGCTTCTGAAGTGTGTGAGGAGTCCATTGCTGTTGGAACCGTGAAGCAC
GAGGGGAATATCAAATACGTGAACGACGTGAGGAACATCACAAAGAAAAATATTGAAGAATGGGGCCCATTTGACTTGGTGATTGGCGGAAGCCCATGCA
ACGATCTCTCAAATGTGAATCCAGCCAGGAAAGGCCTGTATGAGGGTACAGGCCGGCTCTTCTTCGAATTTTACCACCTGCTGAATTACTCACGCCCCAA
GGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAATGTTGTAGCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGTGTAATCCA
GTGATGATTGATGCCATCAAAGTTTCTGCTGCTCACAGGGCCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACT
ACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGA
CTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGC
CCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTG
CCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAGCA
ACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTA
ATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGC
TACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAA
TACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTT
CCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCT
ATAATATAAGCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACAC
CCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACT
CAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTG
GAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTTTA
ACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTC
TATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTG
CTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGTTTAATTAAAATCAGTATTTGTCTATAA
  • DNMT3B.u.f.26 (forward primer)
  • DNMT3B.u.r.28 (reverse primer)
  • Single exon skipping

Frame 0

DGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSK
RQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQ
HFNLATFNKLVSYRKAMYHALEKARVRAGKTFP
SSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPN
NTQPVVNKSKVRRAGSRKLESRKYENKTRRRTAD
DSATSDYCPAPKRLKTNCYNNGKDRGDEDQSRE
QMASDVANNKSSLEDGCLSCGRKNPVSFHPLFE
GGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGR
ELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKL
QEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFT
SDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIA
TGYLVLKELGIKVGKYVASEVCEESIAVGTVKH
EGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPC
NDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPK
EGDDRPFFWMFENVVAMKVGDKRDISRFLECNP
VMIDAIKVSAAHRARYFWGNLPGMNRIFGFPVH
YTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKD
YFACE*FQPGPKPTGVCGRARTQEV*FLKASPG
PALPQLCGSYRVPQFPLAQWGQSHLTLAGVA*G
AASLCTNQTWLLGAA*HGAHFFFS*NFKT*SR*Q
RGFFFFPSWVYHSEKQWLRYQNHSADSSPILRL
MLKNHPRQLLQEFNF*KLATALCLQTCAVVGM*
LQDIFKGPGSFFPRASRRENVVYVFYPAHSPCLN
TRAGVCTGPIRVFSTMMMISAGMTSSSHSGLFF
PPQTQGQGPLLAKSLPVTAIEPSGELRKGCAEF
YNISCHIFCRQVWLLHISLFPRRGV*SKELR*DT
PSNPFPLQETYPPQAQVPR*EVCYPHFSSFY*T
QRQ*QQSGTDIHFSYLPHI*EMTGKTAKLGAPF
GDFLILFYSIRSRF*GEREFRQAAFQKCCHNGF*
HLLLFLLVLFCRIRNNVDKFCGAFYTLFKISNF
YFYV*RFH*NFFCNWSHDVTNMGKKLCLVSTVF
ANF*AER*RMPRVYLMFN*NQYLSI

Frame 1

MGRSLE*GTSCGERSRASPGGPPWWCLGRPPPS
DRLCLACGGSSGLAMASSPRSLQTNWWHWGCSA
STLIWPPSISSSPIEKPCTMLWRKLGCELARPSP
AALETHWRTS*SPCWSGPTGASSPLGSRASNPT
TRNQWLISRRCVVQAVGN*NQGNTRTRLEDAQL
TTQPPLTTAPHPSASRQIAITTAKTEGMKIRAEN
KWLQMLPTTRAAWKMAVCLVAGKTPCPSTLSLR
GGSVRHAGIASLSCFTCMMTMAISLTALCAARA
ESCCFAATRAAAGVSVWSAWRCWWAQAQRPRPSF
RSPGAVTCVSRSAVMASCGAGRTGTCACRPSSP
VTRGLNMKPPSCTLPFPQPEGGPFESCHCLMAS
RQAT*SSKSWA*R*ESTSLLKCVRSPLLLEP*ST
RGISNT*TT*GTSQRKILKNGAHLTW*LAEAHA
TISQM*IQPGKACMRVQAGSSSNFTTC*ITHAP
RRVMTGRSSGCLRML*P*RLATRGTSHGSWSVIQ
**LMPSKFLLLTGPDTSGATYPG*TGSLAFLCT
TQTCPTWAVVPARSCWEGPGACLSSDTSSPL*R
TTLHVNSSSQAPSPLGCVAEPGPRRCDS*RHPQA
LLFLSCVGHTVYLSSLLLSGGRAT*LLQG*PEV
PPPCAQIRPGCLEQPNTVLIFSSPKTLKLEVGS
NVAFFFSLPGSTTQRNNG*DTKTTVPTALQYSG*
C*KIIQDSYCKSLIFENWLLLCVYRRVQL*ACS
YRTFLRAQDRFFPGQAEEKMLYMSFTRHIPLA*
IQGLESARDLLEYFPQ***FQQG*RHHHIQGYFF
PHKPKGRGHS*LNPSP*LQ*NPLGSSGRGVLSS
II*AAIYFVDKYGSSISPSSLGEECEARSLDKT
PPQTHSLSRRPTLHRHRSPDEKSATLISHLFTKL
RGSDSSQGQTYISHTFPTSER*QGKLQSSVLPL
EIF*SFFIP*EVVFRENGNSDKLHFRNAVIMVF
NTFYSSYWCYFVE*GTTLTSFVGLFIHFLKSQTS
IFMFNVFIKIFFVTGATT*QIWGKNCALFQQFL
LIFRLKDDGCLEFTLCLIKISICL*

Frame 2

WEGVWNRGPRVGKDQGLLLVARHGGVLEGHLQA
TGYVWHAVGPVVWRWQVLRGLCRQTGGTGAVQP
AL*FGHLQ*ARLLSKSHVPCSGES*GASWQDLP
QQPWRLIGGPAEAHVGVGPRGLQAHWDRGPQTQQ
HATSG**VEGASCRQ*EIRIKEIREQDSKTHS*
RLSHL*LLPRTQAPQDKLL*QRQRPRG*RSEPR
TNGFRCCQQQEQPGRWLFVLWQEKPRVLPPSL*G
GALSDMPGSLP*AVLHV**RWLSVLLHCVLRGP
RAAALQQHELLPVFLCGVPGGAGGHRHSGRGQA
SGALELLHVSPAALSWRPAAPEGLERAPAGLLHQ
*HGA*I*SPQAVPCHSRSPKAAHSSPVIV*WHR
DRLPSPQRVGHKGRKVRRF*SV*GVHCCWNREA
RGEYQIRERREEHHKEKY*RMGPI*LGDWRKPMQ
RSLKCESSQERPV*GYRPALLRILPPAELLTPQ
GG**PAVLLDV*ECCSHEGWRQEGHLTVPGV*S
SDD*CHQSFCCSQGPILLGQPTRDEQDLWLSCAL
HRRVQHGPWCPPEAAGKVLERACHPTPLRPSEG
LLCM*IVPARPQAHWGVWQSQDPGGVIPEGIPR
PCSSSAVWVIPCTSVPSCSVGAEPPDSCRGSLRC
RLLVHKSDLAAWSSLTRCSFFLLLKL*NLK*VA
TWLFFFPFLGLPLRETMAKIPKPQCRQLSNTQV
NAEKSSKTVIARV*FLKTGYCSVFTDVCSCRHVA
TGHF*GPRIVFSQGKQKRKCCICLLPGTFPLPK
YKGWSLHGTY*SIFHNDDDFSRDDVIITFRAIF
SPTNPRAGATLS*IPPRDCNRTLWGAQEGVC*VL
*YKLPYIL*TSMAPPYLPLP*ERSVKQGA*IRH
PLKPIPSPGDLPSTGTGPQMRSLLPSFLIFLLN
SEAVTAVRDRHTFLIPSPHLRDDRENCKARCSLW
RFFNPFLFHKKSFLGRTGIQTSCISEMLS*WFL
TPFTLLTGAIL*NKEQR*QVLWGFLYTF*NLKL
LFLCLTFSLKFFL*LEPRRNKYGEKTVPCFNSFC
*FLG*KMTDA*SLPYV*LKSVFVY

Sequence DNMT3B.cAug05

ACCCACTCCCGCTGCCCCGTCCGGCCCGCGCCGCTTCCTCGCAGCAGCTGCTCCCGGCTCCGCGGCCGCAGCCCGCGTGGACGCTCCGAGCGCCCCCCGA
CGGACGGGACCGGCTCCCTGGCGGTCGGGCGAGCGGGCGGCAACGCTGCCCGGCCGGCAGCGCTGGGGTTAAGTGGCCCAAGTAAACCTAGCTCGGCGAT
CGGCGCCGGAGATTCGCGAGCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAG
CCAGCCCTGCGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCT
GCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGT
GTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAA
ACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAGGCCTTCCCCACGTTCCACCCGAGGCC
GGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTC
CCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAG
GACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGG
ACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTG
GGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTCTCTGCAGACAAACTGGTGGCACTGGGGCTGTTCAGCCAGCACTTTAATTTGGCCACCTTCAAT
AAGCTCGTCTCCTATCGAAAAGCCATGTACCATGCTCTGGAGAAAGCTAGGGTGCGAGCTGGCAAGACCTTCCCCAGCAGCCCTGGAGACTCATTGGAGG
ACCAGCTGAAGCCCATGTTGGAGTGGGCCCACGGGGGCTTCAAGCCCACTGGGATCGAGGGCCTCAAACCCAACAACACGCAACCAGAGAACAAGACTCG
AAGACGCACAGCTGACGACTCAGCCACCTCTGACTACTGCCCCGCACCCAAGCGCCTCAAGACAAATTGCTATAACAACGGCAAAGACCGAGGGGATGAA
GATCAGAGCCGAGAACAAATGGCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGATGGCTGTTTGTCTTGTGGCAGGAAAAACCCCGTGTCCTTCC
ACCCTCTCTTTGAGGGGGGGCTCTGTCAGACATGCCGGGATCGCTTCCTTGAGCTGTTTTACATGTATGATGACGATGGCTATCAGTCTTACTGCACTGT
GTGCTGCGAGGGCCGAGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTGTTTCTGTGTGGAGTGCCTGGAGGTGCTGGTGGGCACAGGCACAGCG
GCCGAGGCCAAGCTTCAGGAGCCCTGGAGCTGTTACATGTGTCTCCCGCAGCGCTGTCATGGCGTCCTGCGGCGCCGGAAGGACTGGAACGTGCGCCTGC
AGGCCTTCTTCACCAGTGACACGGGGCTTGAATATGAAGCCCCCAAGCTGTACCCTGCCATTCCCGCAGCCCGAAGGCGGCCCATTCGAGTCCTGTCATT
GTTTGATGGCATCGCGACAGGCTACCTAGTCCTCAAAGAGTTGGGCATAAAGGTAGGAAAGTACGTCGCTTCTGAAGTGTGTGAGGAGTCCATTGCTGTT
GGAACCGTGAAGCACGAGGGGAATATCAAATACGTGAACGACGTGAGGAACATCACAAAGAAAAATATTGAAGAATGGGGCCCATTTGACTTGGTGATTG
GCGGAAGCCCATGCAACGATCTCTCAAATGTGAATCCAGCCAGGAAAGGCCTGTATGAGGGTACAGGCCGGCTCTTCTTCGAATTTTACCACCTGCTGAA
TTACTCACGCCCCAAGGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAATGTTGTAGCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGTTC
CTGGAGTGTAATCCAGTGATGATTGATGCCATCAAAGTTTCTGCTGCTCACAGGGCCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTG
GCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTT
CGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTG
AAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAG
GGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAAC
TTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCT
CCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAG
TTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACA
TTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACAT
TCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGG
GGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGA
GCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCA
TCTTTTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGC
TCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTG
TCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTT
AAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTGTGCCTTG
TTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGTTTAATTAAAATCAGTATTTGTCTATAA
  • DNMT3B.u.f.26 (forward primer)
  • DNMT3B.u.r.28 (reverse primer)
  • Single exon skipping

Frame 0

THSRCPVRPAPLPRSSCSRLRGRSPRGRSERPP
TDGTGSLAVGRAGGNAARPAALGLSGPSKPSSAI
GAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQ
PALRQESMKGDTRHLNGEEDAGGREDSILVNGA
CSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRE
TRTRSESPAVRTRNNNSVSSRERHRPSPRSTRG
RQGRNHVDESPVEFPATRSLRRRATASAGTPWPS
PPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQ
DSQQGGMESPQVEADSGDGDSSEYQDGKEFGIG
DLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRW
VQWFGDGKFSEVSADKLVALGLFSQHFNLATFN
KLVSYRKAMYHALEKARVRAGKTFPSSPGDSLE
DQLKPMLEWAHGGFKPTGIEGLKPNNTQPENKTR
RRTADDSATSDYCPAPKRLKTNCYNNGKDRGDE
DQSREQMASDVANNKSSLEDGCLSCGRKNPVSF
HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTA
AEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRL
QAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSL
FDGIATGYLVLKELGIKVGKYVASEVCEESIAV
GTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVI
GGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLN
YSRPKEGDDRPFFWMFENVVAMKVGDKRDISRF
LECNPVMIDAIKVSAAHRARYFWGNLPGMNRIF
GFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLF
APLKDYFACE*FQPGPKPTGVCGRARTQEV*FL
KASPGPALPQLCGSYRVPQFPLAQWGQSHLTLA
GVA*GAASLCTNQTWLLGAA*HGAHFFFS*NFKT
*SR*QRGFFFFPSWVYHSEKQWLRYQNHSADSS
PILRLMLKNHPRQLLQEFNF*KLATALCLQTCA
VVGM*LQDIFKGPGSFFPRASRRENVVYVFYPAH
SPCLNTRAGVCTGPIRVFSTMMMISAGMTSSSH
SGLFFPPQTQGQGPLLAKSLPVTAIEPSGELRK
GCAEFYNISCHIFCRQVWLLHISLFPRRGV*SKE
LR*DTPSNPFPLQETYPPQAQVPR*EVCYPHFS
SFY*TQRQ*QQSGTDIHFSYLPHI*EMTGKTAK
LGAPFGDFLILFYSIRSRF*GEREFRQAAFQKCC
HNGF*HLLLFLLVLFCRIRNNVDKFCGAFYTLF
KISNFYFYV*RFH*NFFCNWSHDVTNMGKKLCL
VSTVFANF*AER*RMPRVYLMFN*NQYLSI

Frame 1

PTPAAPSGPRRFLAAAAPGSAAAARVDAPSAPR
RTGPAPWRSGERAATLPGRQRWG*VAQVNLARR
SAPEIREPSALHGRQPASRQPAPTRGSAAQPRPS
QPCGRKA*RETPGISMERRTPAGGKTRSSSTGP
AATSPPTRPQSWRLSAPRRSEAEDQARDSPRGR
CPVC*ATHRT*QAMATGKMGMALTPQSCQSSSGK
PGLVQKAQLSELEITTVSPAGRGTGLPHVPPEA
GRAATMWTSPPWSSRLPGP*DGGQQHRQERHGR
PLPALTLPSTSQTTQRTHMGRPRAAVPPTPA*PR
TASRGAWSPRRWRQTVEMETVQSIRMGRSLE*G
TSCGERSRASPGGPPWWCLGRPPPSDRLCLACG
GSSGLAMASSPRSLQTNWWHWGCSASTLIWPPSI
SSSPIEKPCTMLWRKLGCELARPSPAALETHWR
TS*SPCWSGPTGASSPLGSRASNPTTRNQRTRL
EDAQLTTQPPLTTAPHPSASRQIAITTAKTEGMK
IRAENKWLQMLPTTRAAWKMAVCLVAGKTPCPS
TLSLRGGSVRHAGIASLSCFTCMMTMAISLTAL
CAARAESCCFAATRAAAGVSVWSAWRCWWAQAQR
PRPSFRSPGAVTCVSRSAVMASCGAGRTGTCAC
RPSSPVTRGLNMKPPSCTLPFPQPEGGPFESCH
CLMASRQAT*SSKSWA*R*ESTSLLKCVRSPLLL
EP*STRGISNT*TT*GTSQRKILKNGAHLTW*L
AEAHATISQM*IQPGKACMRVQAGSSSNFTTC*
ITHAPRRVMTGRSSGCLRML*P*RLATRGTSHGS
WSVIQ**LMPSKFLLLTGPDTSGATYPG*TGSL
AFLCTTQTCPTWAVVPARSCWEGPGACLSSDTS
SPL*RTTLHVNSSSQAPSPLGCVAEPGPRRCDS*
RHPQALLFLSCVGHTVYLSSLLLSGGRAT*LLQ
G*PEVPPPCAQIRPGCLEQPNTVLIFSSPKTLK
LEVGSNVAFFFSLPGSTTQRNNG*DTKTTVPTAL
QYSG*C*KIIQDSYCKSLIFENWLLLCVYRRVQ
L*ACSYRTFLRAQDRFFPGQAEEKMLYMSFTRH
IPLA*IQGLESARDLLEYFPQ***FQQG*RHHHI
QGYFFPHKPKGRGHS*LNPSP*LQ*NPLGSSGR
GVLSSII*AAIYFVDKYGSSISPSSLGEECEAR
SLDKTPPQTHSLSRRPTLHRHRSPDEKSATLISH
LFTKLRGSDSSQGQTYISHTFPTSER*QGKLQS
SVLPLEIF*SFFIP*EVVFRENGNSDKLHFRNA
VIMVFNTFYSSYWCYFVE*GTTLTSFVGLFIHFL
KSQTSIFMFNVFIKIFFVTGATT*QIWGKNCAL
FQQFLLIFRLKDDGCLEFTLCLIKISICL*

Frame 2

PLPLPRPARAASSQQLLPAPRPQPAWTLRAPPD
GRDRLPGGRASGRQRCPAGSAGVKWPK*T*LGD
RRRRFASPAPCTAASRPPASQPRPAAPPPSRAP
ASPAAGKHEGRHQASQWRGGRRREGRLDPRQRGL
QRPVLRLAPNPGGYPHPGDQRPKIKLATLQEGG
VQSAKLHTGLDRRWRRGRWGWL*HPSHAKALPG
NQDSFRKPSCPNSK*QQCLQPGEAQAFPTFHPRP
AGPQPCGRVPRGVPGYQVPETAGNSIGRNAMAV
PSQLLPYHRPHRRHRGHTWDAPEQQYPLRPPSP
GQPAGGHGVPAGGGRQWRWRQFRVSGWEGVWNRG
PRVGKDQGLLLVARHGGVLEGHLQATGYVWHAV
GPVVWRWQVLRGLCRQTGGTGAVQPAL*FGHLQ
*ARLLSKSHVPCSGES*GASWQDLPQQPWRLIGG
PAEAHVGVGPRGLQAHWDRGPQTQQHATREQDS
KTHS*RLSHL*LLPRTQAPQDKLL*QRQRPRG*
RSEPRTNGFRCCQQQEQPGRWLFVLWQEKPRVLP
PSL*GGALSDMPGSLP*AVLHV**RWLSVLLHC
VLRGPRAAALQQHELLPVFLCGVPGGAGGHRHS
GRGQASGALELLHVSPAALSWRPAAPEGLERAPA
GLLHQ*HGA*I*SPQAVPCHSRSPKAAHSSPVI
V*WHRDRLPSPQRVGHKGRKVRRF*SV*GVHCC
WNREARGEYQIRERREEHHKEKY*RMGPI*LGDW
RKPMQRSLKCESSQERPV*GYRPALLRILPPAE
LLTPQGG**PAVLLDV*ECCSHEGWRQEGHLTV
PGV*SSDD*CHQSFCCSQGPILLGQPTRDEQDLW
LSCALHRRVQHGPWCPPEAAGKVLERACHPTPL
RPSEGLLCM*IVPARPQAHWGVWQSQDPGGVIP
EGIPRPCSSSAVWVIPCTSVPSCSVGAEPPDSCR
GSLRCRLLVHKSDLAAWSSLTRCSFFLLLKL*N
LK*VATWLFFFPFLGLPLRETMAKIPKPQCRQL
SNTQVNAEKSSKTVIARV*FLKTGYCSVFTDVCS
CRHVATGHF*GPRIVFSQGKQKRKCCICLLPGT
FPLPKYKGWSLHGTY*SIFHNDDDFSRDDVIIT
FRAIFSPTNPRAGATLS*IPPRDCNRTLWGAQEG
VC*VL*YKLPYIL*TSMAPPYLPLP*ERSVKQG
A*IRHPLKPIPSPGDLPSTGTGPQMRSLLPSFL
IFLLNSEAVTAVRDRHTFLIPSPHLRDDRENCKA
RCSLWRFFNPFLFHKKSFLGRTGIQTSCISEML
S*WFLTPFTLLTGAIL*NKEQR*QVLWGFLYTF
*NLKLLFLCLTFSLKFFL*LEPRRNKYGEKTVPC
FNSFC*FLG*KMTDA*SLPYV*LKSVFVY

Sequence DNMT3B.kAug05

ATTGAAGAATGGGGCCCATTTGACTTGGTGATTGGCGGAAGCCCATGCAACGATCTCTCAAATGTGAATCCAGCCAGGAAAGGCCTGTATGAGGGTACAG
GCCGGCTCTTCTTCGAATTTTACCACCTGCTGAATTACTCACGCCCCAAGGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAATGTTGTAGCCAT
GAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGTGTAATCCAGTGATGATTGATGCCATCAAAGTTTCTGCTGCTCACAGGGCCCGATACTTC
TGGGGCAACCTACCCGGGATGAACAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAACTTTTCCCTGTTGT
CATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCC
CGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCAGGCC
CCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCG
TGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTG
CTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCT
ACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCA
AGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTT
TTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTA
GAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTT
AGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAA
GTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAGACCT
ACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACAT
ACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGA
AGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTT
GTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTT
TTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCT
AGAGTTTACCTTATGTTTAATTAAAATCAGTATTTGTCTATAA
  • DNMT3B.u.f.26 (forward primer)
  • DNMT3B.u.r.28 (reverse primer)
  • Single exon skipping

Frame 0

IEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGT
GRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAM
KVGDKRDISRFLECNPVMIDAIKVSAAHRARYF
WGNLPGMNS*RKYRQ*PPSRTRSNRGKTNFSLL
S*MAKKMFCGALSSKGSLAFLCTTQTCPTWAVVP
ARSCWEGPGACLSSDTSSPL*RTTLHVNSSSQA
PSPLGCVAEPGPRRCDS*RHPQALLFLSCVGHT
VYLSSLLLSGGRAT*LLQG*PEVPPPCAQIRPGC
LEQPNTVLIFSSPKTLKLEVGSNVAFFFSLPGS
TTQRNNG*DTKTTVPTALQYSG*C*KIIQDSYC
KSLIFENWLLLCVYRRVQL*ACSYRTFLRAQDRF
FPGQAEEKMLYMSFTRHIPLA*IQGLESARDLL
EYFPQ***FQQG*RHHHIQGYFFPHKPKGRGHS
*LNPSP*LQ*NPLGSSGRGVLSSII*AAIYFVDK
YGSSISPSSLGEECEARSLDKTPPQTHSLSRRP
TLHRHRSPDEKSATLISHLFTKLRGSDSSQGQT
YISHTFPTSER*QGKLQSSVLPLEIF*SFFIP*E
VVFRENGNSDKLHFRNAVIMVFNTFYSSYWCYF
VE*GTTLTSFVGLFIHFLKSQTSIFMFNVFIKI
FFVTGATT*QIWGKNCALFQQFLLIFRLKDDGCL
EFTLCLIKISICL*

Frame 1

LKNGAHLTW*LAEAHATISQM*IQPGKACMRVQ
AGSSSNFTTC*ITHAPRRVMTGRSSGCLRML*P
*RLATRGTSHGSWSVIQ**LMPSKFLLLTGPDTS
GATYPG*TVKESTDNNHQVELDQTGEKPTFPCC
HEWQRRCFVVH*ARKDLWLSCALHRRVQHGPWC
PPEAAGKVLERACHPTPLRPSEGLLCM*IVPARP
QAHWGVWQSQDPGGVIPEGIPRPCSSSAVWVIP
CTSVPSCSVGAEPPDSCRGSLRCRLLVHKSDLA
AWSSLTRCSFFLLLKL*NLK*VATWLFFFPFLGL
PLRETMAKIPKPQCRQLSNTQVNAEKSSKTVIA
RV*FLKTGYCSVFTDVCSCRHVATGHF*GPRIV
FSQGKQKRKCCICLLPGTFPLPKYKGWSLHGTY*
SIFHNDDDFSRDDVIITFRAIFSPTNPRAGATL
S*IPPRDCNRTLWGAQEGVC*VL*YKLPYIL*T
SMAPPYLPLP*ERSVKQGA*IRHPLKPIPSPGDL
PSTGTGPQMRSLLPSFLIFLLNSEAVTAVRDRH
TFLIPSPHLRDDRENCKARCSLWRFFNPFLFHK
KSFLGRTGIQTSCISEMLS*WFLTPFTLLTGAIL
*NKEQR*QVLWGFLYTF*NLKLLFLCLTFSLKF
FL*LEPRRNKYGEKTVPCFNSFC*FLG*KMTDA
*SLPYV*LKSVFVY

Frame 2

*RMGPI*LGDWRKPMQRSLKCESSQERPV*GYR
PALLRILPPAELLTPQGG**PAVLLDV*ECCSH
EGWRQEGHLTVPGV*SSDD*CHQSFCCSQGPIL
LGQPTRDEQLKKVQTITTKSNSIKQGKNQLFPVV
MNGKEDVLWCTELERIFGFPVHYTDVSNMGRGA
RQKLLGRSWSVPVIRHLFAPLKDYFACE*FQPG
PKPTGVCGRARTQEV*FLKASPGPALPQLCGSYR
VPQFPLAQWGQSHLTLAGVA*GAASLCTNQTWL
LGAA*HGAHFFFS*NFKT*SR*QRGFFFFPSWV
YHSEKQWLRYQNHSADSSPILRLMLKNHPRQLLQ
EFNF*KLATALCLQTCAVVGM*LQDIFKGPGSF
FPRASRRENVVYVFYPAHSPCLNTRAGVCTGPI
RVFSTMMMISAGMTSSSHSGLFFPPQTQGQGPLL
AKSLPVTAIEPSGELRKGCAEFYNISCHIFCRQ
VWLLHISLFPRRGV*SKELR*DTPSNPFPLQET
YPPQAQVPR*EVCYPHFSSFY*TQRQ*QQSGTDI
HFSYLPHI*EMTGKTAKLGAPFGDFLILFYSIR
SRF*GEREFRQAAFQKCCHNGF*HLLLFLLVLF
CRIRNNVDKFCGAFYTLFKISNFYFYV*RFH*NF
FCNWSHDVTNMGKKLCLVSTVFANF*AER*RMP
RVYLMFN*NQYLSI

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